Lane Medical Library

Building C++ applications -- Code organization -- Numbers -- Strings and text -- Dates and times -- Managing data with containers -- Algorithms -- Classes -- Exceptions and safety -- Streams and files -- Science and mathematics -- Multithreading -- Internationalization -- XML -- Miscellaneous.

An overview of C. elegans biology / Kevin Strange -- Comparative genomics in C. elegans, C. briggsae, and other Caenorhabditis species / Avril Coghlan, Jason E. Stajich, and Todd W. Harris -- WormBase: methods for data mining and coparative genomics / Todd W. Harris and Lincoln D. Stein -- C. elegans deletion mutant screening / Robert J. Barstead and Donald G. Moerman -- Insertional mutagenesis in C. elegans using the drosophila transposon Mos1: a method for the rapid identification of mutated genes / Jean-Louis Bessereau -- Single nucleotide polymorphism mapping / M. Wayne Davis and Marc Hammarlund -- Creation of transgenic lines using microparticle bombardment methods / Vida Praitis -- Construction of plasmids for RNA interference and in vitro transcription of double-stranded RNA / Lisa Timmons -- Delivery methods for RNA interference in C. elegans / Lisa Timmons -- Functional genomic approaches in C. elegans / Todd Lamitina -- Assays for toxicity studies in C. elegans with Bt crystal proteins / Larry J. Bischof, Danielle L. Huffman, and Raffi V. Aroian -- Fluorescent reporter methods / Harald Hutter -- Electrophysiological analysis of neuronal and muscle function in C. elegans / Michael M. Francis and Andres Villu Maricq -- Sperm and oocyte isolation methods for biochemical and proteomic analysis / Michael A. Miller -- Preservation of C. elegans tissue via high-pressure freezing and freeze-substitution for ultrastructural analysis and immunocytochemistry / Robby M. Weimer -- Intracellular pH measurements in vivo using green fluorescent protein variants / Keith Nehrke -- Automated imaging of C. elegans behavior / Christopher J. Cronin, Zhaoyang Feng, and William R. Schafer -- Intracellular Ca2+ imaging in C. elegans / Rex A. Kerr and William R. Schafer -- In vitro culture of C. elegans somatic cells / Kevin Strange and Rebecca Morrison -- Techniques for analysis, sorting, and dispensing of C. elegans on the COPAS flow-sorting system / Rock Pulak.

An updated edition of the classic Methods in Cell Biology volume 48, this book emphasizes diverse methods and technologies needed to investigate C. elegans, both as an integrated organism and as a model system for research inquiries in cell, developmental, and molecular biology, as well as in genetics and pharmacology. By directing its audience to tried-and-true and cutting-edge recipes for research, this comprehensive collection is intended to guide investigators of C. elegans for years to come.

Pt.I Genetics and functional genomics :Mapping mutations in C. elegans /Eric J. Lambie --Specialized chromosomes and their uses in caenorhabditis elegans /Martin R. Jones,Zoe Lohn,Ann M. Rose --Genome engineering by transgene-instructed gene conversion in C. elegans /Valérie J.P. Robert,Jean-Louis Bessereau --RNAi methods and screening : RNAi based high-throughput genetic interaction screening /Patricia G. Cipriani,Fabio Piano --Dissection of genetic pathways in C. elegans /Zheng Wang,David R. Sherwood --Pt.II Molecular biology and biochemistry :Transgenesis in C. elegans /Vida Praitis,Morris F. Maduro --RNA processing in C. elegans /J. Jason Morton,Thomas Blumenthal --Analysis of microRNA expression and function /Priscilla M. Van Wynsberghe,Shih-Peng Chan,Frank J. Slack,Amy E. Pasquinelli --In situ hybridization of embryos with antisense RNA probes /Gina Broitman-Maduro,Morris F. Maduro --Gene-centered regulatory network mapping /Albertha J.M. Walhout --Affinity purification of protein complexes in C. elegans /Esther Zanin,Julien Dumont,RetoGassmann,Iain Cheeseman,Paul Maddox,Shirin Bahmanyar,Ana Carvalho,Sherry Niessen,John R. Yates III,Karen Oegema,Arshad Desai --Pt.III Development :Cell indentification and cell lineage analysis /Claudiu A. Giurumescu,Andrew D. Chisholm --Thegenetics and cell biology of fertilization /Brian D. Geldziler,Mathew R. Marcello,Diane C. Shakes,Andrew Singson --Imaging embryonic morphogenesis in C. elegans /Jeff Hardin --Molecular and genetic approaches for the analysis of C. elegans neuronal development /Dong Yan,Yishi Jin --Methods for evaluating the caenorhabditis elegans dauer state : standard dauer-formation assay using synthetic daumones and proteomic analysis of O-GIcNAc modifications /Jeeyong Lee,Kwang-Youl Kim,Kyoe-Jin Joo,Keekyeong Kim,Pan-Young Jeong,Young-Ki Paik.

This book addresses whether or not calcium and magnesium ('hardness') in drinking water can contribute to preventing disease. It includes a comprehensive consensus view on what is known and what is not about the role and possible health benefit of calcium and magnesium in drinking-water. Also included is a series of chapters each authored by internationally renowned experts reviewing the state of the art in different aspects, including: global dietary calcium and magnesium intakes; the contribution of drinking water to calcium and magnesium intake; health significance of calcium and magnesium; role of drinking-water in relation to bone metabolism; epidemiological studies and the association of cardiovascular disease risks with water hardness and magnesium in particular; water production, technical issues and economics.--Publisher's description.

Calcium Handling in hiPSC-Derived Cardiomyocytes --Myocardial Infarction and Heart Failure --Embryonic Stem Cells/Pluripotent Stem Cells --Human Induced Pluripotent Stem Cell (hiPSC)-Derived Cardiomyocytes as a Source for Cardiac Regeneration --Spontaneous Cardiac Differentiation --Mesoderm Enrichment by Wnt-Signaling Growth Factors --Endoderm-Like Cell (END)-2 Co-culture Method --Calcium Homeostasis in Cardiomyocytes --Sarcoplasmic Reticulum (SR) Governs Maturity of Cardiomyocytes --SR Junctional Proteins Play a Role in Calcium Flux Between Cytosol and SR --Spatial and Temporal Ca2+ Wavefront Dictated by T-Tubule Structure --IP3-Mediated Calcium Release Contributes to Whole-Cell Calcium Transients --Calcium Handling Properties of hES-Derived Cardiomyocytes --Calcium Handling Properties of hiPSC-Derived Cardiomyocytes --iPSC-Derived Cardiomyocyte as a Potential Platform for Disease Modeling of the Impaired Calcium Handling-Related Syndrome --Disease Modeling of Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) --Mitochondrial Dysfunction-Related Cardiomyopathy-Impaired SR Ca2+ Reuptake --Measurement of Cytosolic [Ca2+] by Fluorescence Confocal Microscopy --Materials --Calibration of Fluo-3 --Isolation of hiPSC- and hESC-Derived Cardiomyocytes --Recording of Cytosolic [Ca2+] --RT-qPCR of Calcium Handling Proteins.

Bone as the calcium nutrient reserve / Robert P. Heaney -- Cellular functions and fluxes of calcium / Emmanuel M. Awumey and Richard D. Bukoski -- Nutritional epidemiology / Carol J. Boushey -- Clinical approaches for studying calcium metabolism and its relationship to disease / Connie M. Weaver -- Kinetic studies / Meryl E. Wastney, Yongdong Zhao, and Connie M. Weaver -- Requirements for what endpoint / Robert P. Heaney -- Dietary calcium: recommendations and intakes around the world / Anne C. Looker -- Food sources, supplements, and bioavailability / Connie M. Weaver and Robert P. Heaney -- The calcium economy / Robert P. Heaney -- Molecular regulation of calcium metabolism / James C. Fleet -- Influence of total diet on calcium homeostasis / Zamzam K. (Fariba) Roughead -- Influence of lifestyle choices on calcium homeostasis : smoking, alcohol, and hormone therapies / D. Lee Alekel and Oksana Matvienko --Influence of physical activity on calcium and bone / Matthew Vukovich and Bonny Specker -- The case for a calcium appetite in humans / Michael G. Tordoff -- Infancy and childhood / Steven A. Abrams and Keli M. Hawthorne -- Pre-puberty and adolescence / Connie M. Weaver -- Calcium in pregnancy and lactation / Heidi J. Kalkwarf -- Calcium in systemic human health / Robert P. Heaney -- Calcium and oral health / Elizabeth A. Krall -- Dietary calcium and obesity / Dorothy Teegarden -- Polycystic ovarian syndrome and reproduction / Susan Thys-Jacobs -- Premenstrual syndrome / Susan Thys-Jacobs -- Calcium in the later years : osteoporosis / Bess Dawson-Hughes -- Calcium, vitamin D, and cancer / Peter R. Holt -- Dietary calcium and the metabolic syndrome / Dorothy Teegarden -- Calcium and phosphate control in patients with renal disease / David A. McCarron and Robert P. Heaney -- Hypertension and cardiovascular disease / David A. McCarron.

Chapter 1. A Practical Guide to the Preparation of Ca2+ Buffers / Donald M. Bers, Chris W. Patton, Richard Nuccitelli -- Chapter 2. Photorelease Techniques for Raising or Lowering Intracellular Ca2+ / Robert Zucker -- Chapter 3. Making and Using Calcium-Selective Mini- and Microelectrodes / L. Hove-Madsen, S. Baudet, D.M. Bers -- Chapter 4. Construction, Theory, and Practical Considerations for using Self-referencing of Ca2+-Selective Microelectrodes for Monitoring Extracellular Ca2+ Gradients / Mark A. Messerli, Peter J.S. Smith -- Chapter 5. Practical Aspects of Measuring Intracellular Calcium Signals with Fluorescent Indicators / Joseph P.Y. Kao, Gong Li, Darryl A. Auston -- Chapter 6. Genetically Encoded Probes for Measurement of Intracellular Calcium / Michael Whitaker -- Chapter 7. Patch Clamp Methods for Studying Calcium Channels / David L. Armstrong, Christian Erxleben, Jody A. White -- Chapter 8. Nuclear Patch-Clamp Recording from Inositol 1,4,5-Trisphosphate Receptors / Taufiq Rahman, Colin W. Taylor -- Chapter 9. Confocal and Multiphoton Imaging of Intracellular Ca2+ / Godfrey Smith, Martyn Reynolds, Francis Burton, Ole Johan Kemi -- Chapter 10. The Use of Aequorins to Record and Visualize Ca2+ Dynamics: From Subcellular Microdomains to Whole Organisms / Sarah E. Webb, Kelly L. Rogers, Eric Karplus, Andrew L. Miller.

"This volume ... [explores] topics ranging from the fundamental aspects of calcium signaling to its varied clinical implications. It presents comprehensive discussion of cutting-edge research alongside detailed analysis of critical issues, at the same time as setting out testable hypotheses that point the way to future scientific endeavors. The contributions feature material on theoretical and methodological topics as well as related subjects including mathematical modeling and simulations. They examine calcium signaling in a host of contexts, from mammalian cells to oocytes, zebrafish and plants. With much of interest to newcomers to the field as well as seasoned experts, this new publication is both wide-ranging and authoritative." --Excerpt from publisher's description.

Fluorescent measurement of [Ca²+]c: basic practical considerations / Alec W.M. Simpson -- Measurement of [Ca²+]i in whole cell suspensions using fura-2 / Robert A. Hirst ... [et al.] -- Measurement of [Ca²+]i in cell suspensions using indo-1 / Adriaan Nelemans -- Confocal microscopy: theory and applications for cellular signaling / Stephen C. Tovey, Paul J. Brighton, and Gary B. Willars -- Single-cell and subcellular measurement of intracellular Ca²+ concentration / Anthony J. Morgan and Andrew P. Thomas -- Ratiometric Ca²+ measurements using the FlexStation scanning fluorometer / Ian C.B. Marshall, Izzy Boyfield, and Shaun McNulty -- Measuring Ca²+ changes in multiwell format using the fluorometric imaging plate reader / Ian C.B. Marshall, Davina E. Owen, and Shaun McNulty --Measurement of Ca²+ entry using cells ⁴⁵Ca²+ / Mercedes Villarroya ... [et al.] -- Measurement of [³H]PN200-110 and [¹²⁵I]-conotoxin MVIIA binding / Kazuyoshi Hirota and David G. Lambert -- Whole-cell patch clamp recording of voltage-sensitive Ca²+ channel currents: heterologous expression systems and dissociated brain neurons / Atticus H. Hainsworth, Andrew D. Randall, and Alessandro Stefani -- Measurement of phospholipase C by monitoring inositol phosphates using [³H]inositol-labeling protocols in permeabilized cells / Alison Skippen, Philip Swigart, and Shamshad Cockcroft -- Measurement of inositol(1,4,5)triphosphate using a stereospecific radioreceptor mass assay / Darren Smart --Measurement of calcium fluxes in permeabilized cells using a ⁴⁵Ca²+ uptake and release assay / Robert A. Wilcox -- Microinjection of myo-inositol(1,4,5)trisphosphate and other calcium-mobilizing agents into intact adherent cells / Robert A. Wilcox, Ian D. Forsythe, and Terence J. McCann -- Measurement of free [Ca²+] changes in agonist-sensitive internal stores using compartmentalized fluorescent indicators / Aldebaran M. Hofer -- Measurement of [Ca²+]i in smooth muscle strips using front-surface fluorimetry / Hideo Kanaide -- Measurement of calcium and movement in heart cells / Leong L. Ng and Paulene A. Quinn --Simultaneous analysis of intracellular pH and Ca²+ from cell populations / Raul Martinez-Zaguilan ... [et al.] -- Measurement of cytosolic-free Ca²+ in plant tissue / Martin R. McAinsh and Carl K.-Y. Ng -- Assay and purification of calmodulin-dependent protein kinase / Rajendra K. Sharma -- Assay and purification of calmodulin-dependent cyclic nucleotide phosphodiesterase and isozyme separation / Rajendra K. Sharma -- Measurement of Ca²+-ATPase activity (in PMCA and SERCA1) / Danuta Kosk-Kosicka.

Annexinopathies / M.J. Hayes ... [et al.] -- Calpains and human disease / I. Bertipaglia and E. Carafoli -- Gelsolin and diseases / L. Spinardi and W. Witke -- Guanylate cyclase-activating proteins and retina disease / W. Baehr and K. Palczewski -- Pathologies involving the S100 proteins and rage / C.W. Heizmann ... [et al.] -- The calcium-sensing receptor: Physiology, pathophysiology and CaR-based therapeutics / E.M. Brown -- Physiological roles of the Ca2+/CaM-dependent protein kinase cascade in health and disease / J. Colomer and A.R. Means -- Calcium channelopathies: Voltage-gated calcium channels / P.J. Adams and T.P. Snutch -- TRP channels in disease / S.E. Jordt and B.E. Ehrlich -- Diseases associated with altered ryanodine receptor activity / W.J. Durham ... [et al.] -- Inositol 1,4,5-tripshosphate receptor, calcium signalling and Huntington's disease / I. Bezprozvanny -- SERCA pumps and human diseases / A. Hovnanian -- The plasma membrane calcium ATPase and disease / B.L. Tempel and D.J. Shilling -- Diseases involving the Golgi calcium pump / J. Vanoevelen ... [et al.] -- Calcium signalling and cancer cell growth / T. Capiod ... [et al.] -- Calcium misregulation and the pathogenesis of muscular dystrophy / F.W. Hopf ... [et al.] -- Calcium and cell death / A. Verkhratsky -- Calcium and cell death: The mitochondrial connection / P. Bernardi and A. Rasola -- Role of calcium in the pathogenesis of Alzheimer's disease and transgenic models / K.N. Green ... [et al.] -- Calcium and cardiomyopathies / E.G. Kranias and D.M. Bers -- Calcium signalling and calcium transport in bone disease / H.C. Blair ... [et al.].

v. 1. Reviews and case studies -- v. 2. Methods and techniques.

Pending

Chapter 1. Scientific notation and metric prefixes -- Chapter 2. Solutions, mixtures, and media -- Chapter 3. Cell growth -- Chapter 4. Working with bacteriophages -- Chapter 5. Nucleic acid quantification -- Chapter 6. Labeling nucleic acids with radioisotopes -- Chapter 7. Oligonucleotide synthesis -- Chapter 8. The polymerase chain reaction (PCR) -- Chapter 9. The real-time polymerase chain reaction (RT-PCR) -- Chapter 10. Recombinant DNA -- Chapter 11. Protein -- Chapter 12. Centrifugation -- Chapter 13. Forensics and paternity.

Introduction -- Your rights to continuous care, second opinions, referrals and information -- Your right to informed consent -- Your rights to medical records and confidentiality -- Your right to emergency medical care -- Your rights to coverage of pre-existing conditions -- Your rights to file grievances with your health plan and the Department of Managed Health Care -- Your rights to have your HMO's decisions independently reviewed and to sue Your HMO --Your rights to appeal and litigate benefit denials under ERISA -- Health care coverage options -- Appendix A: Department of Managed Health Care's consumer complaint form -- Appendix B: Vital steps to receiving the health care you need, a checklist -- Appendix C: Sample letter -- Appendix D: Strategic advice for patients: tactics to use and understand -- Appendix E: Useful code sections of the California Knox-Keene Health Care Service Plan Act of 1975 and regulations -- Glossary.

Part 1. CALORIE RESTRICTION IN DIFFERENT SPECIES -- History of Caloric Restriction, Aging and Longevity / Edward J. Masoro -- Food Intake, Life Style, Aging and Human Longevity / Arthur V. Everitt, Leonie K. Heilbronn and David G. Le Couteur -- Okinawa: A Naturally Calorie Restricted Population / Matthew W. Rosenbaum, Bradley J. Willcox, D. Craig Willcox and Makoto Suzuki -- Aging and the Effect of Calorie Restriction in Rhesus Monkeys / Ilhem Messaoudi, Jennifer E. Young, Ricki J. Colman, April M. Handy and George S. Roth, et al. -- Dietary Restriction and Aging in Drosophila Melanogaster / Luc Poirier, Rafael de Cabo and Sige Zou -- Aging and Dietary Restriction: The Yeast Paradigm / Min Wei, Federica Madia, Rafael de Cabo and Valter D. Longo -- The Nutritional Geometry of Aging / Stephen J. Simpson and David Raubenheimer -- Part 2. BIOCHEMICAL AND METABOLIC MECHANISMS OF CALORIE RESTRICTION -- Oxidative Stress, Dietary Restriction and Aging / Brian J. Merry and Catherine E. Ash -- Calorie Restriction Mimetics and Aging / Brian J. Morris -- Will Calorie Restriction Stave Off Age-Related Brain Dysfunction, Specifically to Learning and Memory? A Review and Critique of the Rodent Literature / Edward L. Spangler, Jeffrey Long, Bennett Kelley-Bell, Marshall Miller and Robin K. Minor, et al. -- The Aging Liver and the Effects of Long Term Caloric Restriction / David G. Le Couteur, David A. Sinclair, Victoria C. Cogger, Aisling C. McMahon and Alessandra Warren, et al. -- Food Restriction, Hormones, Genes and Aging / Arthur V. Everitt, Holly M. Brown-Borg, David G. Le Couteur and Andrzej Bartke -- Hormesis as a Mechanism for the Anti-Aging Effects of Calorie Restriction / Suresh I.S. Rattan and Dino Demirovic -- Part 3. CALORIE RESTRICTION IN THE CLINICAL SETTING -- Calorie Restriction and Obesity / Krista A. Varady -- Caloric Restriction and Cardiovascular Disease / Anna Csiszar, Rafael de Cabo and Zoltan Ungvari -- The Effect of Caloric Restriction on Physiological, Psychological and Behavioral Outcomes in Humans: Results from CALERIE / Leanne M. Redman and Eric Ravussin -- Calorie Restriction and Cancer: An Update / Robin K. Minor, R. Michael Anson and Rafael de Cabo -- Conclusion: Human Calorie Restriction and Anti-aging Therapy / Arthur V. Everitt, Leonie K. Heilbronn, Brian J. Morris, Holly M. Brown-Borg and Brian J. Merry, et al.

v. 1. General principles -- Reconstructive procedures of the hip in adults -- Reconstructive procedures of the knee in adults -- Reconstructive procedures of the ankle in adults -- Reconstructive procedures of the shoulder and elbow in adults -- Amputations -- Infections -- Tumors -- v. 2. Congenital and developmental disorders -- Nervous system disorders in children -- Fractures and dislocations in children -- The spine -- v. 3. Sports medicine -- Arthroscopy -- Fractures and dislocations in adults -- v. 4. Peripheral nerve injuries -- Microsurgery -- The hand -- The foot and ankle.

v. 1. Anatomy -- Clinical decision making -- Basics of urologic surgery -- Infections and inflammation -- Molecular and cellular biology -- Reproductive and sexual function -- Male genitalia -- v. 2. Renal physiology and pathophysiology -- Upper urinary tract obstruction and trauma -- Renal failure and transplantation -- Urinary lithiasis and endourology -- Neoplasms of the upper urinary tract -- The adrenals -- v. 3. Urine transport, storage, and emptying -- Benign and malignant bladder disorders -- Prostate -- v. 4. Pediatric urology.

Mechanism of action of topoisomerase I poisons / Leroy F. Liu and Shyamal D. Desai -- Crystallographic insight into the mechanism of drug-induced topoisomerase I DNA damage / Alex B. Burgin, Jr., Bart L. Staker, and Lance Stewart -- Inhibitors of topoisomerase I function / Sidney M. Hecht -- Cytotoxic mechanisms of the topoisomerase I inhibitors / Yves Pommier ... [et al.] -- Biochemical and genetic analyses of DNA topoisomerase I-mediated DNA damage / Robert C.A.M. Van Waardenburg and Mary-Ann Bjornsti -- Preclinical models for evaluating topoisomerase-I targeted drugs / Aarti S. Juvekar ... [et al.] -- Mechanisms of resistance to camptothecins / Zeshaan A. Rasheed and Eric H. Rubin -- Recent advances in camptothecin drug design and delivery strategies / Thomas G. Burke ... [et al.] -- Clinical experience with 9-aminocamptothecin: lessons for new drug development / Chris H. Takimoto -- Clinical studies of rubitecan (9-nitro 20(s) camptothecin) / Hilary Hewes, Judith A. Smith, and Claire Verschraegen -- Irinotecan: current clinical status and pharmacological aspects / Laurent P. Rivory -- Clinical experience with topotecan / Aimee K. Bence and Val R. Adams -- The clinical development of lurtotecan: experience with water-soluble and liposomal forms / Keith T. Flaherty ... [et al.] -- Preclinical and clinical development of dx-8951f (exatecan mesylate): a hexacyclic camptothecin analog / Eric K. Rowinsky -- Camptothecins in the treatment of primary brain tumors / Clinton F. Stewart, Markos Leggas, and Henry S. Friedman -- Camptothecins in the treatment of lung cancer / Pankaj Kumar ... [et al.] -- Use of camptothecins in the treatment of leukemia and related disorders / Bejamin M.F. Mow and Scott H. Kaufmann.

Once upon a time -- A tale of two killers -- Radiography -- Kill or be killed -- A big problem with cancer -- Cancerous tissues -- Genital system cancers -- Urinary system cancers -- Chest and abdomen cancers -- Head and neck cancers -- Digestive system cancers -- Benign tumors and other maladies.

1. Obesity and Cancer Epidemiology -- 2. Obesity and Cancer: Epidemiology in Racial/Ethnic Minorities -- 3. Obesity and Cancer in Asia -- 4. Genetic Epidemiology of Obesity and Cancer -- 5. Obesity and Cancer: Overview of Mechanisms -- 6. Caloric Restriction and Cancer -- 7. Physical Activity and Cancer -- 8. Energy Balance, Cancer Prognosis, and Survivorship -- 9. Behavior, Energy Balance, and Cancer: An Overview -- 10. Geographic and Contextual Effects on Energy Balance-Related Behaviors and Cancer.

This title is a medical reference for doctors caring for people whose kidney disease is complicated by cancer, or whose cancer is complicated by kidney problems. This is an overlap area in medicine that is often difficult to manage. This book addresses that area and should help kidney doctors as well as cancer doctors to care for their patients.

Peyton Rous: A Centennial Tribute to the Founding Father of Cancer Virology --Viruses and Cancer: A Historical Perspective - HBV and Prevention of a Cancer --Virus-Mediated Cell Proliferation --Viral-Encoded Genes and Cancer --Oncogenic Viruses and Cancer Transmission --DNA Viruses and Cancer: Taking a Broader Look --Herpesviruses and Cancer --Lymphocryptoviruses: EBV and Its Role in Human Cancer --Nonhuman Primate Gamma-herpesviruses and Their Role in Cancer --Rhadinoviruses: KSHV and Associated Malignancies --Retroperitoneal Fibromatosis Herpesvirus and Kaposi's Sarcoma-Like Tumors in Macaques --Murine Gammaherpesvirus-Associated Tumorigenesis --Marek's Disease Virus-Induced T-Cell Lymphomas --Polyomaviruses and Cancer --Polyomavirus SV40: Model Infectious Agent of Cancer --BK Polyomavirus and Transformation --Polyomavirus JC and Human Cancer: Possible Role of Stem Cells in Pathogenesis --Merkel Cell Polyomavirus --Human Papillomaviruses and Cancer --Tumorigenesis by Adenovirus Type 12 E1A --Overview of Hepatitis Viruses and Cancer --Hepadnaviruses and Hepatocellular Carcinoma --Hepatitis C Virus and Hepatocellular Carcinoma --Human and Animal Retroviruses: HIV-1 Infection Is a Risk Factor for Malignancy --HTLV-1 and Oncogenesis --Human T-Cell Leukemia Virus Type 2 (HTLV-2) Biology and Pathogenesis --Mechanisms of Oncogenesis by Avian and Murine Retroviruses --Rous Sarcoma Virus: Contributions of a Chicken Virus to Tumor Biology, Human Cancer Therapeutics, and Retrovirology --Mouse Mammary Tumor Virus and Cancer --Jaagsiekte Sheep Retrovirus and Lung Cancer --Small RNAs and Their Role in Herpesvirus-Mediated Cancers --Viral Malignancies in HIV-Associated Immune Deficiency.

A path to knowledge : from data to complex systems models of cancer / Sylvia Nagl -- Theory of cancer robustness / Hiroaki Kitano -- Developing an integrated informatics platform for cancer research / Richard Begent -- Mathematical models of cancer / Manish Patel and Sylvia Nagl -- Some mathematical modelling challenges and approaches in cancer / Philip Maini and Robert A. Gatenby -- Computer simulation of tumour response to therapy / Georgios S. Stamatakos and Nikolaos Uzunoglu -- Structural bioinformatics in cancer / Stephen Neidle -- The mouse tumour biology database : an online resource for mouse models of human cancer / Carol J. Bult ... [et al.] -- Bioinformatics approaches to integrate cancer models and human cancer research / Cheryl L. Marks and Sue Dubman -- The FAPESP/LICR human cancer genome project : perspectives on integration / Ricardo Brentani ... [et al.].Today's science, tomorrow's patient : the pivotal role of tissue, clinical data and informatics in modern drug development / Kirstine Knox, Amanda Taylor and David J. Kerr -- Software design ethics for biomedicine / Don Gotterbarn and Simon Rogerson -- Ethical issues of electronic patient data and informatics in clinical trial settings / Dipak Kalra and David Ingram -- Pharmacogenomics and cancer : ethical, legal and social issues / Mary Anderlik Majumder and Mark Rothstein.

Clinical strategies for cancer treatment: the role of drugs -- Target identification and drug discovery -- Clinical drug development and marketing approval -- Principles of pharmacokinetics -- Delivering anticancer drugs to brain tumors -- Pharmacogenetics -- Physical barriers to drug delivery -- Antifolates -- 5-fluoropyrimidines -- Cytidine analogues -- Purine antimetabolites -- Hydroxyurea -- Antimitotic drugs -- Alkylating agents -- Platinum analogues -- Bleomycin and other antitumor antibiotics -- Topoisomerase I-targeting drugs -- Topoisomerase II inhibitors: anthracyclines -- Topoisomerase II inhibitors: the epipodophyllotoxins -- Asparaginase -- Proteasome inhibitors -- Histone deacetylase inhibitors in oncology -- Differentiating agents -- Arsenic trioxide -- Antibodies -- Inhibitors of tumor angiogenesis -- Epidermal growth factor receptor inhibitors -- HER2 inhibitors -- Molecular targeted drugs -- Signaling inhibitors: IGFR, PI3K pathway, embryonic signaling inhibitors, and mitotic kinase inhibitors -- Cytokine therapy for cancer -- Cancer vaccines -- Adoptive cellular therapies -- Thalidomide and its analogs in the treatment of hematologic malignancies, including multiple myeloma, and solid tumors -- Hormonal therapy of breast cancer -- Hormone therapy for prostate cancer -- Drug therapy of pain in cancer patients -- Hematopoietic growth factors -- Antinausea medications -- Bisphosphonates and other bone-targeted therapies -- Intravenous access and catheter management -- Late effects of cancer chemotherapy -- Infertility after cancer chemotherapy.

The Theoretical Basis of Cancer Chemotherapy --Practical Aspects of Cancer Chemotherapy --Chemotherapy in the Management of Cancer.

Historical perspective and evolving concerns for human research / Bernard Lo and Nesrin Garan -- Cancer trials and the Institutional Review Board (IRB) / Scott Kurtzman and Zita Lazzarini -- NCI's cancer therapy evaluation program: a commitment to treatment trials / Jeffrey S. Abrams, Anthony Murgo and Michaele C. Christian -- Practical guide for cancer clinical investigators / Steven Hirschfeld -- The role of cooperative groups in cancer clinical trials / Ann M. Mauer, Elizabeth S. Rich and Richard L. Schilsky -- The advocate role in clinical study development and partnering with patient advocates in your local institution / Barbara Parker -- The National Breast Cancer Coalition: setting the standard for advocate collaboration in clinical trials / Fran Visco -- The role of the principal investigator in cancer clinical trials / Stanley P.L. Leong -- The audit process and how to ensure a successful audit / Y. Nancy You, Lisa Jacobs, Elizabeth Martinez and David M. Ota -- The privacy rule (HIPAA) as it relates to clinical research / John M. Harrelson and John M. Falletta -- The Commission on Cancer, American College of Surgeons' response to HIPAA / E. Greer Gay -- Ethical and legal issues in the conduct of cancer clinical trials / Gerianne J. Sands and Peggy A. Means -- The role of the Office of Research Integrity in cancer clinical trials / Peter Abbrecht, Nancy Davidian, Samuel Merrill and Alan R. Price -- Strategies for the administration of a clinical trial infrastructure: lessons from a comprehensive cancer center / Leonard A. Zwelling and Carleen A Brunelli -- The clinical research process: building a system in harmony with its users / Greg Koski -- Cancer research and clinical trial in action: an important exercise before you embark on your study / Stanley P.L. Leong, Larry Carbone and Scott Kurtzman.

Module 1. Planning -- Module 2. Prevention -- Module 3. Early detection -- Module 4. Diagnosis and treatment -- Module 5. Palliative care -- Module 6. Policy and advocacy.

A new approach to an old problem / Sverre Heim and Felix Mitelman -- Cytogenetic methods / David Gisselsson -- Cytogenetic nomenclature / Sverre Heim and Felix Mitelman -- Nonrandom chromosome abnormalities in cancer : an overview / Sverre Heim and Felix Mitelman -- Acute myeloid leukemia / Bertil Johansson and Christine J. Harrison -- Myelodysplastic syndromes / Harold J. Olney and Michelle M. Le Beau -- Chronic myeloid leukemia / Thoas Fioretos and Bertil Johansson -- Chronic myeloproliferative neoplasms / Peter Vandenberghe, Lucienne Michaux, and Anne Hagemeijer -- Acute lymphoblastic leukemia / Christine J. Harrison and Bertil Johansson -- Mature B- and T-cell neoplasms and Hodgkin lymphoma / Reiner Siebert -- Tumors of the upper aerodigestive tract / Mihaela Avramut and Susanne M. Gollin -- Tumors of the lung / Penny Nymark, Eeva Kettunen, and Sakari Knuutila -- Tumors of the digestive tract / Georgia Bardi and Sverre Heim -- Tumors of the urinary tract / Paola Dal Cin and Azra H. Ligon -- Tumors of the breast / Manuel R. Teixeira, Nikos Pandis, and Sverre Heim -- Tumors of the female genital organs / Francesca Micci and Sverre Heim -- Tumors of the male genital organs / Manuel R. Teixeira and Sverre Heim -- Tumors of endocrine glands / Jörn Bullerdiek and David Gisselsson -- Tumors of the nervous system / Aaron M. Bender ... [et al.] -- Tumors of the eye / Karen Sisley -- Tumors of the skin / Fredrik Mertens and Sverre Heim -- Tumors of bone / Fredrik Mertens and Nils Mandahl -- Soft tissue tumors / Nils Mandahl and Fredrik Mertens.

v. 1. Host susceptibility factors -- v. 2. Modifiable factors.

The role of epigenetics in cancer / Trygve O. Tollefsbol -- DNA hypomethylation in cancer / Peter L. Molloy -- DNA hypermethylation in oncogenesis / J. Tyson DeAngelis ... [et al.] -- Imprinting alterations in tumorigenesis / Jeremiah Bernier-Latmani and Phillip Shaw -- Proteins that modulate DNA methylation aberrations in cancer / Sabrina L. Walthall ... [et al.] -- The role of DNA methylation in cancer progression / Sang-Woon Choi and Simonetta Friso -- Alterations in histone acetylation in tumorigenesis / Sabita N. Saldanha and Trygve O. Tollefsbol -- Histone methylation and the initiation of cancer / Shi Huang -- The role of sirtuins in aging and tumorigenesis / Xiaohong Zhang ... [et al.] -- Proteins that alter histone modifications in cancer / Ada Ao and Jianrong Lu -- Dietary and environmental influences on histone modifications in cancer / Sabita N. Saldanha ... [et al.] -- Noncoding RNAs in cancer / Maciej Szymanski and Jan Barciszewski -- Cancer-linked DNA hyper- and hypomethylation: chromosome positional effects / Melanie Ehrlich -- Chromatin remodeling and cancer / Sari Pennings and Richard R. Meehan --Poly-ADP-ribosylation in cancer / Rajeshwar N. Sharan -- Polycomb group proteins in tumorigenesis / Hanneke E.C. Niessen and Jan Willem Voncken -- Cancer and aging: the epigenetic connection / Craig A. Cooney -- DNA methylation in tumor diagnosis / Kavitha Ramachandran, Edna Gordian, and Rakesh Singal -- DNA methylation profiles as prognostic markers for cancer / Sam Thiagalingam and Panagiotis Papageorgis -- Diagnosing cancer using histone modification analysis / Mukesh Verma and Deepak Kumar -- Histone modifications in cancer biology and prognosis / Matthew A. McBrian, David B. Seligson, and Siavash K. Kurdistani -- Histone deacetylase inhibitors in cancer therapy / Aaron M. Sargeant ... [et al.] -- Methylation changes in neoplasia: diagnostic and therapeutic implications / Eleftheria Hatzimichael, Justin Stebbing, and Tim Crook -- Clinical trials and approved drugs for epigenetic cancer therapy / Debby M.E.I. Hellebrekers and Manon van Engeland -- Future directions in epigenetic cancer research / Jacob Peedicayil.

Cancer gene therapy : historical perspective / Malcolm K. Brenner -- The genetic basis of cancer / Akseli Hemminki and Kari Hemminki -- Tumor suppressor gene replacement for cancer / Jack A. Roth and Susan F. Grammer -- Antisense technology / Ruiwen Zhang and Hui Wang -- Cancer therapeutic applications of ribozymes and RNAi / Lisa Scherer and John J. Rossi -- Fusogeneic membrane glycoproteins for cancer gene therapy : a better class of killer / Andrew Bateman ... [et al.] -- Suicide gene therapy / Caroline J. Springer and Ion Niculescu-Duvaz -- Molecular chemotherapy approaches / Daniel H. Palmer and David J. Kerr -- Genetic immunotherapy approaches / Denise R. Shaw and Albert F. LoBuglio -- Immunotherapy of cancer by dendritic cell-targeted : gene transfer / Tanja D. de Gruijl, Herbert M. Pinedo, and Rik J. Scheper -- Dendritic cells / Weiping Zou, Shuang Wei and Tyler J. Curiel --Polynucleotide immunization for cancer therapy / Theresa V. Strong -- Development of oncolytic replication-competent herpes simplex virus vectors: the G207 paradigm / Tomoki Todo and Samuel D. Rabkin -- Development of oncolytic adenoviruses : from the lab bench to the bedside / John A. Howe, Robert Ralston, and Murali Ramachandra -- Conditionally replicating adenoviruses for cancer treatment / Ramon Alemany -- Reovirus as an oncolytic agent / Megan K. Patrick, Kara L. Norman, and Patrick W. K. Lee -- Antiangiogenic gene therapy of cancer / Steve Gyorffy ... [et al.] -- Proapoptotic strategy in cancer gene therapy / David H. Holman ... [et al.] -- Antimetastasis / Duen-Hwa Yan, Kung-Ming Rau, and Mien-Chie Hung -- Antimetastatic gene therapy : prostate cancer theory to therapy / Thomas A. Gardner ... [et al.] --Drug-resistance gene transfer as an antitumor strategy / Colin L. Sweeney and R. Scott McIvor -- Chemosensitization / Per Eystein Lønning -- Radiosensitization by gene therapy / Steven J. Chmura, Michael Garofalo, and Ralph R. Weichselbaum -- Nonviral vector systems for cancer gene therapy / Greg F. Walker and Ernst Wagner -- Viral vectors for cancer gene therapy / Joanne T. Douglas and David T. Curiel -- Bacterial systems for tumor-specific gene therapy / J. Martin Brown ... [et al.] -- Molecular imaging of cancer gene therapy / Harvey R. Herschman -- Cancer-related gene therapy clinical trials / Robert J. Korst and Ronald G. Crystal -- Regulatory aspects in the development of gene therapies / Rosemarie Aurigemma ... [et al.].

Reciprocal subtraction differential RNA display (RSDD) : an efficient technology for cloning differentially expressed genes / Devanand Sarkar, Dong-chul Kang, and Paul B. Fisher -- Cloning differentially expressed genes using rapid subtraction hybridization (RaSH) / Habib Boukerche ... [et al.] -- The application of differential display as a gene profiling tool / Ken Chien-Neng Chang ... [et al.] -- Serial analysis of gene expression (SAGE) / Fred van Ruissen and Frank Baas -- Gene expression profile analysis of tumors / Katia Basso and Riccardo Dalla-Favera -- cDNA microarray and bioinformatic analysis of nuclear factor [kappa]B related genes in squamous cell carcinoma / Zhong Chen ... [et al.] -- Gene profiling uncovers retinoid target genes / Yan Ma ... [et al.] -- Complete open reading frame (C-ORF) technique : rapid and efficient method for obtaining complete protein coding sequences / Dong-chul Kang and Paul B. Fisher -- Chromatin immunoprecipitation assays : molecular analysis of chromatin modification and gene regulation / Piyali Dasgupta and Srikumar P. Chellappan -- Manipulating genes and gene copy number by bacterial artificial chromosome transfection / Stephanie F. Phelps, Sharon Illenye, and Nicholas H. Heintz -- Molecular cytogenetic applications in analysis of the cancer genome / Pulivarthi H. Rao, Subhadra V. Nandula, and Vundavalli V. Murty -- Monitoring methylation and gene expression in cancer / Hetty Carraway and James Herman -- The use of phage display peptide libraries for basic and translational research / Renee Brissette and Neil I. Goldstein -- Yeast and mammalian two-hybrid systems for studying protein-protein interactions / Shu-ichi Matsuzawa and John C. Reed -- Ribonomic and short hairpin RNA gene silencing methods to explore functional gene programs associated with tumor growth arrest / Timothy E. Baroni ... [et al.] -- Surface-epitope masking (SEM) : an immunological subtraction approach for developing monoclonal antibodies targeting surface-expressed molecules / Neil I. Goldstein and Paul B. Fisher -- Approaches for monitoring signal transduction changes in normal and cancer cells / Paul Dent ... [et al.] -- PKR in innate immunity, cancer, and viral oncolysis / Siddharth Balachandran and Glen N. Barber -- Analysis of transformation and tumorigenicity using mouse embryonic fibroblast cells / Hong Sun and Reshma Taneja -- Analysis of growth properties and cell cycle regulation using mouse embryonic fibroblast cells / Hong Sun, Neriman Tuba Gulbagci, and Reshma Taneja -- Reverse phase protein microarrays for monitoring biological responses / Virginia Espina ... [et al.] -- Protein crystallization / Champion Deivanayagam, William J. Cook, and Mark R. Walter.

Immunotherapy and cancer therapeutics : why partner? / Leisha A. Emens and Elizabeth M. Jaffee -- Immune stimulatory features of classical chemotherapy / Robbert G. van der Most, Anna K. Nowak, and Richard A. Lake -- Dendritic cells and coregulatory signals : immune checkpoint blockade to stimulate immunotherapy / Drew Pardoll -- Regulatory T cells in tumor immunity : role of toll-like receptors / Rong-Fu Wang -- Tumor-associated macrophages in cancer growth and progression / Alberto Mantovani, Paola Allavena, and Antonio Sica -- Tumor-associated myeloid-derived suppressor cells / Stephanie K. Bunt ... [et al.] -- Programmed death ligand-1 and galectin-1 : pieces in the puzzle of tumor-immune escape / Gabriel A. Rabinovich and Thomas F. Gajewski -- Indoleamine 2,3-dioxygenase in immune escape : regulation and therapeutic inhibition / Alexander J. Muller and George C. Prendergast -- Arginase, nitric oxide synthase, and novel inhibitors of L-arginine metabolism in immune modulation / Susanna Mandruzzato, Simone Mocellin, and Vincenzo Bronte.Introduction / George C. Prendergast and Elizabeth M. Jaffee -- Cancer immunoediting : from immune surveillance to immune escape / Ryungsa Kim -- Immunosurveillance : innate and adaptive antitumor immunity / Masahisa Jinushi and Glenn Dranoff -- Cytokine regulation of immune tolerance to tumors / Ming O. Li and Richard A. Flavell -- Immunological sculpting : natural killer cell receptors and ligands / David A. Sallman and Julie Y. Djeu -- Immune escape : immunosuppressive networks / Shuang Wei, Alfred Chang, and Weiping Zou -- Cytotoxic chemotherapy in clinical treatment of cancer / Rajesh Thirumaran, George C. Prendergast, and Paul B. Gilman -- Targeted therapeutics in cancer treatment / Colin D. Weekes and Manuel Hidalgo -- Concepts in pharmacology and toxicology / Richard A. Westhouse and Bruce D. Car -- Cancer immunotherapy : challenges and opportunities / Andrew J. Lepisto, John R. McKolanis, and Olivera J. Finn -- Cancer vaccines / Freda K. Stevenson ... [et al.] --

Introduction / W. Archie Bleyer ... [et al.] -- History of adolescent oncology / Cameron K. Tebbi -- Epidemiology and etiology of cancer in adolescents and young adults / Jillian M. Birch and W. Archie Bleyer -- Access to care before and during therapy / Karen H. Albritton and Tim Eden -- Older adolescents and young adults with cancer, and clinical trials: lack of participation and progress in North America / W. Archie Bleyer, Troy Budd, and Michael Montello -- Acute lymphoblastic leukemia / James Nachman, Giuseppe Masera, and W. Archie Bleyer -- Acute myelogenous leukemia / Ursula Creutzig and William G. Woods -- Hodgkin lymphoma / Tanya M. Trippett ... [et al.] -- Non-hodgkin lymphoma / Catherine Patte, W. Archie Bleyer, and Mitchell S. Cairo -- Central nervous system tumors in adolescents and young adults / David A. Walker ... [et al.] -- Soft-tissue sarcomas / Karen H. Albritton, Andrea Ferrari, and Michela Casanova -- Bone sarcomas / Michael S. Isakoff ... [et al.] -- Malignancies of the ovary / Jubilee Brown, Thomas Olson, and Susan Sencer -- Testicuar tumors / John W. Cullen and Robert Fallon -- Non-germ-cell genitourinary tract tumors / Michael Leahy and W. Archie Bleyer -- Thyroid cancer / Steven G. Waguespack and Samuel A. Wells --Malignant melanoma / Cynthia E. Herzog, W. Archie Bleyer, and Alberto S. Pappo -- Breast cancer / Marianne Phillips, Banu Arun, and W. Archie Bleyer -- Liver tumors / Marcio H. Malogolowkin, Arthur Zimmermann, and Jack Plaschkes -- Colorectal cancer / Wayne L. Furman, D. Ashley Hill, and Michael LaQuaglia -- Models of care and specialized units / Ian Lewis and Sue Morgan -- Drug compliance by adolescent and young adult cancer patients: challenges for the physician / Benjamin Gesundheit ... [et al.] -- Psychological support for adolescents and young adults / Christine Eiser and Aura Kuperberg -- Psychosocial support / Brad J. Zebrack, Mark A. Chesler, and Anthony Penn -- Health-related quality of life / Ernest R. Katz ... [et al.] -- Rehabilitation and exercise / Marilyn J. Wright -- Adolescent and young adult cancer survivors: late effects of treatment / Smita Bhatia ... [et al.] -- Ethical issues for the adolescent and young adult cancer patient: assent and end-of-life care / Susan Shurin and Eric Kodish -- Access to care after therapy / Karen E. Kinahan ... [et al.] -- Future health of survivors of adolescent and young adult cancer / Melissa M. Hudson and Kevin C. Oeffinger -- Information and resources for young adults and adolescents with cancer / David R. Freyer and Leonard J. Mattano -- Making ends meet: financial issues from the perspectives of patients and their healthcare team / David R. Freyer and Ronald D. Barr -- Challenges and opportunities - the way ahead / W. Archie Bleyer ... [et al.].

The epidemiology of cancer in children -- Genetics of childhood malignancies -- Molecular biology of childhood tumours -- The principles for cancer chemotherapy in children -- Future trends in cancer chemotherapy -- Radiotherapy in paediatric oncology -- Surgery in paediatric oncology -- Supportive care during treatment -- Psychosocial issues -- Palliative care -- Late effects of cancer treatment and current protective measures -- Acute lymphoblastic leukaemia -- Acute myeloid leukaemia -- Non-hodgkin lymphoma -- Hodgkin disease -- Langerhans cell histiocytosis -- Tumours of the central nervous system -- Soft tissue sarcoma -- Osteosarcoma -- Ewing sarcoma and peripheral primitive neuroectodermal tumour -- Nephroblastoma -- Nephroblastoma -- Germ cell tumours in children and adolescents -- Hepatic tumours -- Retinoblastoma -- Rare tumours.

Cancer biology -- Cancer immunology -- Cancer etiology -- Cancer epidemiology, prevention, and screening -- Clinical trials and outcomes assessment -- Cancer pathology -- Imaging -- Surgical oncology -- Radiation oncology -- Medical oncology -- Chemotherapy -- Chemotherapeutic agents -- Biotherapeutics -- Endocrine therapy -- Gene therapy -- Bone marrow transplantation -- Psycho-oncology -- Oncology nursing -- Cancer rehabilitation medicine -- Multidisciplinary management -- Pain and palliation -- Societal oncology -- Central nervous system -- The Eye -- Endocrine glands -- Head and neck -- The Thorax -- Gastrointestinal tract -- Genitourinary tract -- Female reproductive organs -- The Breast -- The Skin -- Bone and soft tissue -- Hematopoietic system -- Neoplasms in AIDS --- Unknown primary site -- Pediatric oncology -- Complications of cancer and their treatment -- Infection in the cancer patient -- Oncologic emergencies -- Oncology and informatics.

1. Biological Aspects of Tumour Angiogenesis / Federico Bussolino, Marco Arese, Enrica Audero, Enrico Giraudo, Serena Marchio, Stefania Mitola, Luca Primo, Guido Serini -- 2. Novel Directions in Tumour Biology / Cèdric Plachot, Sophie A. Leliévre -- 3. Interstitial Transport in Solid Tumours / Paolo A. Netti, Rakesh K. Jain -- 4. Modelling Avascular Tumour Growth / Helen M. Byrne -- 5. Mechanical Models in Tumour Growth / Davide Ambrosi, Francesco Mollica -- 6. Modelling Tumour-Induced Angiogenesis / H. A. Levine, B. D. Sleeman -- 7. Multi-Scale Analysis of Angiogenic Dynamics and Therapy / Levon Arakelyan, Yifat Merbl, Peteris Daugulis, Yuval Ginosar, Vladimir Vainstein, Vera Selitser, Yuri Kogan, Hila Harpak, Zvia Agur -- 8. Adhesion Mechanisms in Cancer Metastasis / Anne Leyrat, Alain Duperray, Claude Verdier -- 9. Static and Dynamic Interactions between Endothelium and Circulating Cells in Cancer / Roxana Chotard-Ghodsnia, Agnès Drochon, Alain Duperray, Anne Leyrat, Claude Verdier -- 10. Mathematical Modelling of Tissue Invasion / Mark A. J. Chaplain, Alexander R. A. Anderson -- 11. Cancer Immune System Competition / Nicola Bellomo, Maria Letizia Bertotti, Santo Motta -- 12. Analysing Hypersensitivity to Chemotherapy in a Cellular Automata Model of the Immune System / Filippo Castiglione, Vera Sleitser, Zvia Agur -- 13. Reaction-Diffusion Systems / Miguel A. Herrero.

Overview -- Diagnostic studies -- Neurologic symptoms -- Direct complications of cancer -- Indirect complications of cancer -- Complications of cancer therapy -- Neurologic complications of specific malignancies.

Epidemiology of brain tumors -- Neuropathology of central nervous system tumors -- Clinical presentation of patients with brain tumors -- Imaging in central nervous system tumors -- Single photo emission computed topography in the evaluation of adult primary brain tumors -- Positron emission tomography for the management of brain tumors -- Magnetic resonance spectroscopy and its use in brain tumor diagnosis and therapy -- Functional magnetic resonance imaging for neurosurgery -- Principles of pediatric brain tumor surgery -- Principles of brain tumor surgery in adults -- Image-guided surgery -- Principles of brain tumor radiotherapy -- Biologic-based brain tumor therapy -- Chemotherapy for central nervous system tumors -- Immunotherapy for malignant gliomas -- Gene therapy -- Management of non-neoplastic problems in brain tumor patients -- Psychiatric management of brain tumor patients -- Meningiomas: natural history, diagnosis, and imaging -- Meningioma: surgery -- Meningioma: skull base surgery -- Radiosurgery in the treatment of meningiomas -- Radiotherapy in the treatment of meningiomas -- Medical management of meningiomas -- Vestibular schwannoma: overview of natural history and diagnosis -- Surgery in the treatment of vestibular schwannoma -- Radiosurgery in the treatment of vestibular schwannomas -- Fractionated stereotactic radiotherapy in the treatment of acoustic neuromas -- Vestibular schwannomas in the setting of neurofibromatosis type 2 -- Medical management of pituitary adenomas -- Surgery for pituitary adenoma --Fractionated conformal radiotherapy in the treatment of pituitary tumors -- Craniopharyngiomas -- Nerve sheath tumors of the spine -- Low-grade supratentorial glioma -- Pediatric low-grade gliomas of the chiasm and cerebellum -- Malignant gliomas -- Sarcomas -- Ependymomas -- Medulloblastoma and other primitive neuroectodermal tumors -- Hemangioblastoma -- Tumors of the pineal region -- Central nervous system lymphoma in AIDS and non-AIDS patients -- Gliomas of the spine -- Vertebral body tumors -- Rare malignant brain tumors -- Surgery for brain metastases -- Radiotherapy and radiosurgery for brain metastases -- Epidural disease -- Neoplastic meningitis -- Paraneoplastic disorders of the nervous system -- Hereditary brain tumor syndromes -- Growth factors in brain tumors -- Angiogenesis in brain tumors -- Invasion in brain tumors -- Molecular genetics of brain tumors -- Predicting medulloblastoma outcome -- Predictive markers in human gliomas -- Molecular neuropathology -- Molecular markers of metastatic disease -- Stem cell biology and brain tumors -- Issues regarding death and dying in brain tumor patients.

Proteomics technologies -- Cell signaling proteomics -- Tumor proteomics -- Bioinformatics and regulatory aspects of proteomics.

Cancer stem cells : historical perspectives and lessons from leukemia / Christopher R. Cogle -- Cancer stem cells in breast cancer / Jenny E. Chu and Alison L. Allan -- Cancer stem cells in brain cancer / Xin Wang, Chitra Venugopal, and Sheila K. Singh -- Cancer stem cells in colorectal cancer / Mauro Biffoni, Eros Fabrizi, and Lucia Ricci-Vitiani -- Cancer stem cells in pancreatic cancer / Jorge Dorado, Alicia G. Serrano, and Christopher Heeschen -- Cancer stem cells in prostate cancer / Paula Kroon ... [et al.] -- Cancer stem cells in melanoma / Ping Jin ... [et al.] -- Cancer stem cells in lung cancer / Jun Shen and Feng Jiang -- Cancer stem cells in ovarian cancer / Fang Fang ... [et al.] -- Cancer stem cells in hepatocellular cancer / Russell C. Langan and Itzhak Avital -- Cancer stem cells in head and neck cancer / Mark E.P. Prince and Samantha J. Davis -- Relationship between regulatory pathways in pluripotent stem cells and human tumors / Olga Gaidarenko and Yang Xu -- Influence of the embryonic microenvironment on tumor progression / Daniela Quail ... [et al.] -- The epithelial-to-mesenchymal transition and cancer stem cells / Jonas Fuxe -- Application of stem cell assays for the characterization of cancer stem cells / Pamela M. Willan and Gillian Farnie -- Zebrafish as a model to study stem cells in development, disease, and cancer / Viviana Anelli, Cristina Santoriello, and Marina C. Mione -- Imaging cancer stem cells / Paula Foster -- Mouse models for studying normal and cancer stem cells / David A. Hess -- Cancer stem cells and disease prognosis / Zeshaan A. Rasheed, Jeanne Kowalski, and William H. Matsui -- Mechanisms of radioresistance in cancer stem cells / Cleo Y-F Lee and Maximilian Diehn -- The role of ABC transporters in cancer stem cell drug resistance / Vera S. Donnenberg, Ludovic Zimmerlin, and Albert D. Donnenberg -- Resistance to endocrine therapy in breast cancer : are breast cancer stem cells implicated? / Ciara S. O'Brien ... [et al.] -- Future directions : cancer stem cells as therapeutic targets / Alysha K. Croker and Alison L. Allan -- Final thoughts : complexity and controversy surrounding the "cancer stem cell" paradigm / Craig Gedye, Richard P. Hill, and Laurie Ailles.

Cancer survivors: a physician's perspective / Patricia A. Ganz -- Cancer survivorship: a nursing perspective / Susan Leigh -- Oncology social work for survivorship / Patricia Fobair -- Survivorship research: past, present, and future / Julia H. Rowland -- Surveillance after primary therapy / Craig C. Earle -- Late effects of cancer treatments / Noreen M. Aziz -- Medical and psychosocial issues in childhood cancer survivors / Smita Bhatia ... [et al.] -- Medical and psychosocial issues in Hodgkin's disease survivors / Jon Håvard Loge and Stein Kaasa -- Medical and psychosocial issues in testicular cancer survivors / S.D. Fosså, L.B. Travis, and A.A. Dahl -- Medical and psychosocial issues in gynecologic cancer survivors / Karen Basen-Engquist and Diane C. Bodurka -- Medical, psychosocial, and health-related quality of life issues in breast cancer survivors / Julie Lemieux, Louise J. Bordeleau, and Pamela J. Goodwin -- Medical and psychosocial issues in prostate cancer survivors / Tracey L. Krupski and Mark S. Litwin -- Physical and psychosocial issues in lung cancer survivors / Linda Sarna, Frederic W. Grannis, and Anne Coscarelli -- Cancer survivorship issues in colorectal cancer / Clifford Y. Ko and Patricia A. Ganz -- Medical and psychosocial issues in transplant survivors / Karen L. Syrjala ... [et al.] -- Cancer survivorship issues in older adults / Karim S. Malek and Rebecca A. Silliman -- Second malignancies after radiation treatment and chemotherapy for primary cancers / Lydia B. Zablotska, Matthew J. Matasar, and Alfred I. Neugut -- Psychosocial rehabilitation in cancer care / Richard P. McQuellon and Suzanne C. Danhauer -- Reproductive complications and sexual dysfunction in cancer survivors / Leslie R. Schover -- The employment and insurance concerns of cancer survivors / Barbara Hoffman -- Cancer advocacy / Ellen L. Stovall -- The survivorship care plan: what, why, how, and for whom / Craig C. Earle ... [et al.]

A roadmap of cancer systems biology / Edwin Wang -- Network biology : the framework of systems biology / Jing-Dong Han -- Reconstructing gene networks using gene expression profiles / Mario Lauria and Diego di Bernardo -- Understanding cancer progression in protein interaction networks / Jinsheng Sun, Jie Li, and Edwin Wang -- From tumor genome sequencing to cancer signaling maps / Cong Fu and Edwin Wang -- Ubiquitin-mediated regulation of human signaling networks in normal and cancer cells / Cong Fu, Jie Li, and Edwin Wang -- MicroRNA regulation of networks of normal and cancer cells / Pradeep Kumar Shreenivasaiah, Do Han Kim, and Edwin Wang -- Network model of survival signaling in T-cell large granular lymphocyte leukemia / Ranran Zhang, Thomas P. Loughran Jr., and Réka Albert -- Cancer metabolic networks : metabolic pathways modelling and metabolomics in cancer research / Miroslava Cuperlovic-Culf -- Warburg revisited : modeling energy metabolism for cancer systems biology / Mathieu Cloutier --Cancer gene prediction using a network approach / Xuebing Wu and Shao Li -- Cancer genomics to cancer biology / Maria Luz Jaramillo and Chabane Tibiche -- Epithelial-to-mesenchymal transition (EMT) : the good, the bad, and the ugly / Anne EG Lenferink -- Tumors and their microenvironments / Nicholas R. Bertos and Morag Park -- Tumor angiogenesis : cell-microenvironment interactions / Ally Pen, Danica B. Stanimirovic, and Maria J. Moreno -- Modeling tools for cancer systems biology / Wayne Materi and David S. Wishart -- Advanced visualization, analysis, and inference of biological networks using visANT / Zhenjun Hu -- Gene set and pathway-based analysis for cancer omics / Dougu Nam and Seon-Young Kim -- SH2 domain signaling network and cancer / Shawn S.-C. Li and Thamara K.J. Dayarathna -- Data sources and computational tools for cancer systems biology / Yun Ma, Pradeep Kumar Shreenivasaiah, and Edwin Wang.

The Cancer Genome -- Mechanisms of Genomic Instability -- Epigenetics of Cancer -- Telomeres, Telomerase, and Cancer -- Cell Signaling Growth Factors and Their Receptors -- Cell Cycle -- Mechanisms of Cell Death -- Cancer Metabolism -- Angiogenesis -- Invasion and Metastasis -- Cancer Stem Cells -- Biology of Personalized Cancer Medicine -- Tobacco -- Cancer Susceptibility Syndromes -- DNA Viruses -- RNA Viruses -- Inflammation -- Chemical Factors -- Physical Factors -- Dietary Factors -- Obesity and Physical Activity -- Epidemiologic Methods -- Global Cancer Incidence and Mortality -- Trends in Cancer Mortality -- Surgical Oncology: General Issues -- Surgical Oncology: Laparoscopic Surgery -- Radiation Oncology -- Medical Oncology -- Assessment of Clinical Response -- Cancer Immunotherapy -- Health Services Research and Economics of Cancer Care -- Pharmacokinetics and Pharmacodynamics -- Pharmacogenomics -- Alkylating Agents -- Platinum Analogs -- Antimetabolites -- Topoisomerase-Interacting Agents -- Antimicrotubule Agents -- Targeted Therapy with Small Molecule Kinase Inhibitors -- Histone Deacetylase Inhibitors and Demethylating Agents -- Proteasome Inhibitors -- Poly(ADP-Ribose) Polymerase Inhibitors -- Miscellaneous Chemotherapeutic Agents -- Interferons -- Interleukin Therapy -- Antisense Agents -- Antiangiogenesis Agents -- Monoclonal Antibodies -- Endocrine Manipulation -- Preventive Cancer Vaccines -- Tobacco Dependence and Its Treatment -- Role of Surgery in Cancer Prevention -- Principles of Cancer Risk Reduction Intervention -- Retinoids, Carotenoids, and Other Micronutrients in Cancer Prevention -- Drugs and Nutritional Extracts for Cancer Risk Reduction (Chemoprevention) -- Principles of Cancer Screening -- Early Detection Using Proteomics -- Screening for Gastrointestinal Cancers -- Screening for Gynecologic Cancers -- Screening for Breast Cancer -- Screening for Prostate Cancer -- Screening for Lung Cancer -- Genetic Counseling -- Vascular Access and Specialized Techniques -- Interventional Radiology -- Functional Imaging -- Molecular Imaging --Photodynamic Therapy -- Biomarkers -- Design and Analysis of Clinical Trials -- Molecular Biology of Head and Cancers -- Treatment of Head and Neck Cancer -- Rehabilitation after Treatment of Head and Neck Cancer -- Molecular Biology of Lung Cancer -- Non-Small Cell Lung Cancer -- Small Cell and Neuroendocrine Tumors of the Lung -- Neoplasms of the Mediastinum -- Molecular Biology of the Esophagus and Stomach -- Cancer of the Esophagus -- Cancer of the Stomach -- Molecular Biology of Pancreas Cancer -- Cancer of the Pancreas -- Molecular Biology of Liver Cancer -- Cancer of the Liver -- Cancer of the Biliary Tree -- Cancer of the Small Intestine -- Gastrointestinal Stromal Tumor -- Molecular Biology of Colorectal Cancer -- Cancer of the Colon -- Cancer of the Rectum -- Cancer of the Anal Region -- Molecular Biology of Kidney Cancer -- Cancer of the Kidney -- Molecular Biology of Bladder Cancer -- Cancer of the Bladder, Ureter, and Renal Pelvis -- Molecular Biology of Prostate Cancer -- Cancer of the Prostate -- Cancer of the Urethra and Penis -- Cancer of the Testis -- Molecular Biology of Gynecologic -- Cancer of the Cervix, Vagina, and Vulva -- Cancers of the Uterine Body -- Gestational Trophoblastic Neoplasms -- Ovarian Cancer, Fallopian Tube Carcinoma, and Peritoneal Carcinoma -- Molecular Biology of Breast Cancer -- Malignant Tumors of the Breast -- Molecular Biology of Endocrine Tumors -- Thyroid Tumors -- Parathyroid Tumors -- Adrenal Tumors -- Pancreatic Neuroendocrine Tumors -- Neuroendocrine (Carcinoid) Tumors and the Carcinoid Syndrome -- Multiple Endocrine Neoplasias -- Molecular Biology of Soft Tissue Sarcoma -- Soft Tissue Sarcoma -- Sarcomas of Bone -- Cancer of the Skin -- Molecular Biology of Cutaneous Melanoma -- Cutaneous Melanoma -- Molecular Biology of Central Nervous System Tumors -- Neoplasms of the Central Nervous System -- Molecular Biology of Childhood Cancers -- Solid Tumors of Childhood -- Leukemias and Lymphomas of Childhood -- Molecular Biology of Lymphomas -- Hodgkin Lymphoma -- Non-Hodgkin Lymphomas -- Cutaneous Lymphomas --Primary Central Nervous System Lymphoma -- Molecular Biology of Acute Leukemias -- Management of Acute Leukemias -- Molecular Biology of Chronic Leukemias -- Chronic Myelogenous Leukemia -- Chronic Lymphocytic Leukemias -- Myelodysplastic Syndromes -- Plasma Cell Neoplasms -- Cancer of Unknown Primary Site -- Benign and Malignant Mesothelioma -- Peritoneal Surface Malignancy -- Intraocular Melanoma -- AIDS-Related Malignancies -- Transplantation-Related Malignancies -- Superior Vena Cava Syndrome -- Increased Intracranial Pressure -- Spinal Cord Compression -- Metabolic Emergencies -- Metastatic Cancer to the Brain -- Metastatic Cancer to the Lung -- Metastatic Cancer to the Liver -- Metastatic Cancer to the Bone -- Malignant Effusions of the Pleura and the Pericardium -- Malignant Ascites -- Paraneoplastic Syndromes -- Autologous Stem Cell Transplantation -- Allogeneic Stem Cell Transplantation -- Infections in the Cancer Patient -- Leukopenia and Thrombocytopenia -- Cancer-Associated Thrombosis -- Nausea and Vomiting -- Diarrhea and Constipation -- Oral Complications -- Pulmonary Toxicity -- Cardiac Toxicity -- Hair Loss -- Gonadal Dysfunction -- Fatigue -- Second Primary Cancers -- Neurocognitive Effects -- Cancer Survivorship -- Management of Cancer Pain -- Nutritional Support -- Sexual Problems -- Psychological Issues in Cancer -- Communicating News to the Cancer Patient -- Specialized Care of the Terminally Ill -- Community Resources -- Rehabilitation of the Cancer Patient -- Regulatory Issues -- Health Disparities in Cancer -- Cancer Information on the Internet -- Complementary, Alternative, and Integrative Therapies in Cancer Care.

Introduction for scientists -- Introduction for laypersons -- What cancers are -- Environmental and other causes of cancer -- Resources used to detect local increases in risk -- Methods used to detect local increases in risk -- Errors due to chance -- Comparison between "apples" and "oranges" -- Failure to detect local increases in risk -- Investigating a lead -- Guide to the figures -- Interpretation -- Scientific and technical notes -- Oropharyngeal carcinoma -- Salivary gland malignancies -- Squamous carcinoma of the esophagus/gastric cardia -- Adenocarcinoma of the esophagus/gastric cardia -- Adenocarcinoma of the (lower) stomach -- Carcinoma of the small intestine -- Colon carcinoma, total (both upper and sigmoid) -- Carcinoma of the upper colon -- Carcinoma of the sigmoid colon -- Carcinoma of the rectum -- Hepatocellular carcinoma -- Cholangiocarcinoma -- Gallbladder carcinoma -- Biliary tract carcinoma -- Pancreas carcinoma -- Carcinoma of the nose/sinuses -- Carcinoma of the larynx -- Lung and bronchus carcinoma, total (all types) -- Squamous cell carcinoma of the lung and bronchus -- Large cell carcinoma of the lung and bronchus -- Small cell carcinoma of the lung and bronchus -- Adenocarcinoma of the lung and bronchus -- Bronchioloalveolar carcinoma of the lung and bronchus -- Undifferentiated carcinoma of the lung and bronchus -- Carcinoma of the lung and bronchus, not otherwise classified -- Mesothelioma -- Soft tissue sarcoma -- Angiosarcoma -- Kaposi sarcoma -- Osteosarcoma -- Ewing's sarcoma -- Malignant chordoma -- Malignant melanoma -- Breast carcinoma -- Squamous cervix carcinoma (invasive) -- Endometrial (uterine corpus) carcinoma -- Epithelial carcinoma of the ovary -- Germ cell malignancies --Prostate carcinoma -- Anogenital adenocarcinoma -- Anogenital squamous carcinoma -- Mixed cell genital tumors -- Transitional cell (non-squamous) bladder carcinoma -- Squamous bladder carcinoma -- Renal cell carcinoma -- Wilms tumor (nephroblastoma) -- Retinoblastoma -- Brain malignancies (gliomas) -- Spinal cord malignancies -- Neurolemoma (nerve sheath malignancy) -- Neuroblastoma -- Malignant meningioma -- Papillary carcinoma of the thyroid -- Follicular carcinoma of the thyroid -- Other carcinoma of the thyroid -- Pituitary carcinoma -- Multiple endocrine neoplasia -- Carcinoma of the thymus -- Mixed cellularity Hodgkin lymphoma -- Nodular sclerosis Hodgkin lymphoma -- Other Hodgkin lymphoma -- All non-Hodgkin lymphomas (all non-Hodgkin lymphoma types) -- Follicular non-Hodgkin lymphoma -- Diffuse large B-cell non-Hodgkin lymphoma -- Diffuse small lymphocytic or plasmacytic B-cell non-Hodgkin lymphoma -- Diffuse mixed B-cell non-Hodgkin lymphoma -- High-grade non-Hodgkin lymphoma -- T-cell non-Hodgkin lymphoma -- Maltoma non-Hodgkin lymphoma -- Other non-Hodgkin lymphoma -- Central nervous system non-Hodgkin lymphomas (all non-Hodgkin lymphoma types) -- Stomach non-Hodgkin lymphomas (all non-Hodgkin lymphoma types) -- Other gastrointestinal non-Hodgkin lymphomas (all non-Hodgkin lymphoma types) -- Lymph node/other organ non-Hodgkin lymphomas (all non-Hodgkin lymphoma types) -- Multiple myeloma -- Acute lymphoblastic leukemia -- Chronic lymphocytic leukemia -- Hairy cell leukemia -- Acute non-lymphocytic leukemia -- Chronic myelocytic leukemia -- Other leukemias -- All malignancies of infants/toddlers -- All malignancies of older children -- All malignancies of young adults -- All malignancies of older adults -- All malignancies -- Overall summary.

Isolation of dendritic cells from human blood for in vitro interaction studies with fungal antigens / T. Sreevalsan -- Detection and quantitation of antifungal SIgA antibodies in body fluids / Michael F. Cole -- Phagocytosis and killing assays for Candida species / Chen Du and Richard A. Calderone -- Immunization protocols for use in animal models of candidiasis / Esther Segal and Hana Sandovsky-Losica -- Penetration of antifungal agents through Candida biofilms / L. Julia Douglas -- Candida biofilm analysis in the artificial throat using FISH / Bastiaan P. Krom ... [et al.] -- Conditions for optimal Candida biofilm development in microtiter plates / Bastiaan P. Krom ... [et al.] -- Animal models of candidiasis / Cornelius J. Clancy, Shaoji Cheng, and Minh H. Nguyen -- Candida albicans gene expression in an in vivo infection model / Michael D. Kruppa -- In vitro and ex vivo assays of virulence in Candida albicans / Richard A. Calderone -- Biotyping of Candida albicans and other fungi by yeast killer toxins sensitivity / Luciano Polonelli and Stephania Conti -- DNA fingerprinting Candida species / Claude Pujol and David R. Soll -- The application of tandem-affinity purification to Candida albicans / Chris Blackwell and Jeremy D. Brown -- Preparation of samples for proteomic analysis of the Candida albicans cell wall / Neeraj Chauhan -- Reporter gene assays in Candida albicans / Joy Sturtevant -- Genetic transformation of Candida albicans / Ana M. Ramon and William A. Fonzi -- Large-scale gene disruption using the UAU1 cassette / Clarissa J. Nobile and Aaaron P. Mitchell -- Standard growth media and common techniques for use with Candida albicans / Neeraj Chauhan and Michael D. Kruppa.

"The ouput of eukaryotic genomes is much more complex than expected. Genes produce different variants of RNAs from multiple promoters. One of the ultimate targets of biological analysis is to establish a relationship between the messenger RNAs that are transcribed from the genome and the genomic regions that control their expression - the promoters - in order to decipher the networks that regulate gene expression and the transcription factors that act as master regulators of transcriptional control.""Novel technologies have recently appeared that allow deciphering of transcriptional network, based on the identification of the starting site of gene transcription, with the simultaneous measurement of expression level and identification of the promoter elements. These tagging technologies (including cap-analysis gene expression - CAGE - and others) are further boosted from the development of the novel generation of sequencing instruments, which allow transcriptional profiling by sequencing at the cost of microarray experiments.""This book is a guide for users of new technologies, as it includes accurately proven protocols, allowing readers to prepare their samples for experiments. Additionally, it provides a guide for the bioinformatics tools that are available for the analysis of the obtained tags, including the design of the software, the sources and web information where they can be downloaded. Finally, the book provides examples of the application of these technologies to identify promoters, annotate genomes, identify new RNAs and reconstruct models of transcriptional control. Although examples mainly regard mammalians, the discussion expands to other groups of eukaryotes, where these approaches are complementing genome sequencing"--P. [4] of cover.

Part I: Analyte-oriented -- Determination of small icons with capillary electrophoresis and contactless conductivity detection / Andreas Zemann, Irene Rohregger, and Roland Zitturi -- Metal analysis with capillary zone electrophoresis / Ashok Kumar Malik - Measurement of low-molecular-weight carboxylic acids in ambient air and vehicle emission by capillary electrophoresis / Ewa Dabek-Zlotorzynska and Valbona Celo -- Determination of aliphatic low-molecular-weight and biogenic amines by capillary zone electrophoresis / Agnes Fekete ... [et al.] -- Capillary electrophoretic analysis of organic pollutants / Ashok Kumar Malik, Jatinder Singh Aulakh, and Varinder Kaur -- Capillary electrophoresis with laser-induced fluorescence: environmental applications / Lee Riddick and William C. Brumley -- Practical considerations for the analysis of ionic and neutral organic molecules with capillary electrophoresis/mass spectrometry / Moritz Frommberger, Matthias Englmann, and Philippe Schmitt-Kopplin -- Analysis of the enantiomers of chiral pesticides and other pollutants in environmental samples by capillary electrophoresis / Arthur W. Garrison, Philippe Schmitt-Kopplin, and Jimmy K. Avants -- Capillary electrophoresis of tropane alkaloids and glycoalkaloids occurring in solanaceae plants / Tommaso R. I. Cataldi and Giuliana Bianco -- Capillary electrophoresis for pharmaceutical analysis / Alex Marsh ... [et al.] -- Capillary electrophoresis of neutral carbohydrates: mono-, oligosaccharides, and glucosides / Cristiana Campa and Marco Rossi -- Capillary electrophoresis of sugar acids / Cristiana Campa, Edi Baiutti, and Anna Flamigni -- Use of capillary electrophoresis for polysaccharide studies and applications / Amelia Gamini ... [et al.] -- Analysis of oligonucleotides using capillary zone electrophoresis and electrospray mass spectrometry / An Willems, Dieter L. Deforce, and Jan Van Bocxlaer -- Separation of DNA by capillary electrophoresis / Bruce McCord, Brittany Hartzell-Baguley, and Stephanie King -- Capillary electrophoresis of oxidative DNA damage / Guowang Xu ... [et al.] -- Capillary electrophoresis of gene mutation / Guowang Xu ... [et al.] -- Biomedical applications of amino acid detection by capillary electrophoresis / Giuseppe E. De Benedetto -- Separation of peptides by capillary electrophoresis / Gerhard K. E. Scriba and Arndt Psurek -- Analysis of proteins by capillary electrophoresis / Christian W. Huck and Günther K. Bonn -- Separation of synthetic (Co)polymers by capillary electrophoresis techniques / Hervé Cottet and Pierre Gareil -- Capillary electrophoresis separation of microorganisms / Bartolomé M. Simonet, Angel Ríos, and Miguel Valcárcel -- Part II: Methods-oriented -- A semi-empirical approach for a rapid comprehensive evaluation of the electrophoretic behaviors of small molecules in free-zone electrophoresis / Philippe Schmitt-Kopplin and Agnes Fekete -- The CE way of thinking: all is relative! / Philippe Schmitt-Kopplin and Agnes Fekete -- Adsorbed cationic polymer coatings for enhanced capillary electrophoresis/mass spectrometry of proteins / Sara Ullsten, Aida Zuberovic, and Jonas Bergquist -- On-column ligand/receptor derivatization coupled to affinity capillary electrophoresis / Jose Zavaleta ... [et al.] -- On-line concentration of environmental pollutant samples by using capillary electrophoresis / Janpen Intaraprasert and Philip J. Marriott -- Free-flow electrophoresis system for proteomics applications / Gerhard Weber and Robert Wildgruber -- Microemulsion electrokinetic chromatography / Wolfgang W. Buchberger -- Micellar electrokinetic chromatography of aminoglycosides / Ulrike Holzgrabe, Stefanie Laug, and Frank Wienen -- Capillary electrochromatography and on-line concentration / Guichen Ping ... [et al.] -- Analysis of alkaloids in single plant cells by capillary electrophoresis / Katrin Wieland, Björn Thiele, and Uli Schurr -- Multi-dimensional capillary electrophoresis and chromatography for proteomic analysis / Mingxia Gao and Xiangmin Zhang.

Overview of Capillary Electrophoresis in Pharmaceutical Analysis -- Theoretical Consideration in Performance of Various Modes of CE -- Equipment Considerations for Capillary Electrophoresis -- Method Development for Pharmaceutical Analysis -- Role of CE in Drug Substance and Drug Product Development -- General Considerations to Improve Performance of CE Methods -- Overview of Current Regulatory Guidance -- Qualification of CE Instrumentation -- Robustness Testing of CE Methods -- Validation of Analytical Methods Using Capillary Electrophoresis-- The Need for CE Methods in Pharmacopeial Monographs -- CE in Impurity Profiling of Drugs -- Ion Analysis Using Capillary Electrophoresis -- Role of CE in Biopharmaceutical Development and Quality Control -- Capillary Electrophoresis and Bioanalysis -- CE as an Orthogonal Technique to Chromatography -- Capillary Electrochromatography of Pharmaceuticals -- Coupling CE and Chip-based Devices and Mass Spectrometry.

Frontal analysis continuous capillary electrophoresis for protein-polyelectrolyte binding studies / Emek Seyrek, Toshiaki Hattori, and Paul L. Dubin -- Analysis of proteins by CE, CIEF, and microfluidic devices with whole column imaging detection / Jiaqi Wu ... [et al.] -- Capillary electrophoresis-electrospray ionization mass spectrometry of amino acids, peptides, and proteins / Mehdi Moini -- Capillary isoelectric focusing-mass spectrometry of proteins and protein complexes / Suzana Martinović, Ljiljana Paša-Tolić, and Richard D. Smith -- Integrated system for rapid proteomics analyses using microfluidics devices coupled to nanoelectrospray mass spectrometry / Jianjun Li ... [et al.].Surfactant based methods for prevention of protein adsorption in capillary electrophoresis / Charles A. Lucy, Nicole E. Baryla, and Ken K.-C. Yeung -- Capillary coating for protein separation based on Si-O and Si-C covalent bond formation for capillary electrophoresis with laser-induced fluorescence detection / Hossein Ahmadzadeh, Norman J. Dovichi, and Sergey Krylov -- On-column labeling reaction for the analysis of protein contents of a single cell using capillary electrophoresis with laser-induced fluorescence detection / Hossein Ahmadzadeh and Sergey Krylov -- Covalent and noncovalent labeling schemes for near-infrared dyes in capillary electrophoresis protein applications / John Sowell ... [et al.] -- Capillary electrophoresis in the analysis and monitoring of biotechnological processes / Vadim Klyushnichenko --Capillary electrophoresis of proteins in a quality control environment / David L. Good ... [et al.] -- Analysis of neutral N-linked oligosaccharides from antibodies using free-solution capillary electrophoresis in bare fused silica capillaries / Jeffrey S. Patrick ... [et al.] -- Affinity capillary electrophoresis to examine receptor-ligand interactions / Maryam Azad ... [et al.] -- Screening major binding sites on human serum albumin by affinity capillary electrophoresis / Hee Seung Kim, John Austin, and David S. Hage -- Using charge ladders and capillary electrophoresis to measure the charge, size, and electrostatic interactions of proteins / Upma Sharma and Jeffrey D. Carbeck --

Introduction and perspective -- Basic pathology, anatomy, and pathophysiology of stroke -- Diagnosis and the clinical encounter -- Imaging and laboratory diagnosis -- Treatment -- Large artery occlusive disease of the anterior circulation -- Large vessel occlusive disease of the posterior circulation -- Penetrating and branch artery disease -- Brain embolism -- Hypoxic-ischemic encephalopathy, cardiac arrests, and cardiac encephalopathy -- Nonatherosclerotic vasculopathies -- Subarachnoid hemorrhage, aneurysms, and vascular malformations -- Intracerebral hemorrhage -- Stroke in children and young adults -- Spinal cord vascular disease -- Cerebral venous thrombosis -- Stroke prevention -- Complications in stroke patients -- Recovery and rehabilitation.

ch. 1. Synthetic methodologies / Chikako Saotome, Osamu Kanie -- ch. 2. Complex carbohydrate synthesis / Makoto Kiso, Hideharu Ishida, Hiromune Ando -- ch. 3. The chemistry of sialic acid / Geert-Jan Boons, Alexei V. Demchenko -- ch. 4. Solid-phase oligosaccharide synthesis / Peter H. Seeberger -- ch. 5. Solution and polymer-supported synthesis of carbohydrates / Shin-Ichiro Nishimura -- ch. 6. Enzymatic synthesis of oligosaccharides / Jianbo Zhang, Jun Shao, Prezemk Kowal, Peng George Wang -- ch. 7. Glycopeptides and glycoproteins : synthetic chemistry and biology / Oliver Seitz -- ch. 8. Synthesis of complex carbohydrates : Everninomicin 13,384-1 / K. C. Nicolaou, Helen J. Mitchell, Scott A. Snyder -- ch. 9. Chemical synthesis of asparagine-linked glycoprotein oligosaccharides : recent examples / Yukishige Ito, Ichiro Matsuo -- ch. 10. Chemistry and biochemistry of asparagine-linked protein glycosylation / Barbara Imperiali, Vincent W.-F. Tai -- ch. 11. Conformational analysis of C-glycosides and related compounds : programming conformational profiles of C- and O-glycosides / Peter G. Goekjian, Alexander Wei, Yoshito Kishi -- ch. 12. Synthetic lipid A antagonists for sepsis treatment / William J. Christ, Lynn D. Hawkins, Michael D. Lewis, Yoshito Kishi -- ch. 13. Polysialic acid vaccines / Harold J. Jennings -- ch. 14. Synthetic carbohydrate-based vaccines / Stacy J. Keding, Samuel J. Danishefsky -- ch. 15. Chemistry, biochemistry, and pharmaceutical potentials of glycosaminoglycans and related saccharides / Tasneem Islam, Robert J. Linhardt -- ch. 16. A new generation of antithrombotics based on synthetic oligosaccharides / Maurice Petitou, Jean-Marc Herbert -- ch. 17. Sequencing of oligosaccharides and glycoproteins / Stuart M. Haslam, Kay-Hooi Khoo, Anne Dell -- ch. 18. Preparation of heterocyclic 2-deoxystreptamine aminoglycoside analogues and characterization of their interaction with RNAs by use of electrospray ionization mass spectrometry / Richard H. Griffey, Steven A. Hofstadler, Eric E. Swayze -- ch. 19. Glycosylation analysis of a recombinant P-selectin antagonist by high-pH anion-exchange chromatography with pulsed electrochemical detection (HPAEC/PED) / Mark R. Hardy, Richard J. Cornell -- ch. 20. Analytical techniques for the characterization and sequencing of glycosaminoglycans / Ram Sasisekharan, Zachary Shriver, Mallik Sundaram, Ganesh Venkataraman -- ch. 21. Thermodynamic models of the multivalency effect / Pavel I. Kitov, David R. Bundle -- ch. 22. Synthetic multivalent carbohydrate ligands as effectors or inhibitors of biological processes / Laura L. Kiessling, Jason K. Pontrello, Michael C. Schuster -- ch. 23. Glycosyltransferase inhibitors / Karl-Heinz Jung, Richard R. Schmidt -- ch. 24. RNA-aminoglycoside interactions / Haim Weizman, Yitzhak Tor -- ch. 25. Glycosylated natural products / Jon S. Thorson, Thomas Vogt -- ch. 26. Novel enzymatic mechanisms in the biosynthesis of unusual sugars / Alexander Wong, Xuemei He, Hung-Wen Liu -- ch. 27. Neoglycolipids : identification of functional carbohydrate epitopes / Ten Feizi, Alexander M. Lawson, Wengang Chai -- ch. 28. A preamble to aglycone reconstruction for membrane-presented glycolipid mimics / Murugesapillai Mylvaganam, Clifford A. Lingwood -- ch. 29. Small molecule inhibitors of the sulfotransferases / Dawn E. Verdugo, Lars C. Pedersen, Carolyn R. Bertozzi -- ch. 30. Carbohydrate-based treatment of cancer metastasis / Reiji Kannagi -- ch. 31. N-acetylneuraminic acid derivatives and mimetics as anti-influenza agents / Robin Thomson, Mark Von Itzstein -- ch. 32. Modified and modifying sugars as a new tool for the development of therapeutic agents : the biochemically engineered N-acyl side chain of sialic acid : biological implications and possible uses in medicine / Rüdiger Horstkorte, Oliver T. Keppler, Werner Reutter -- ch.33 . Modified and modifying sugars as a new tool for the development of therapeutic agents : glycosidated phospholipids as a new type of antiproliferative agents / Kerstin Danker, Annette Fischer, Werner Reutter -- ch. 34. Glycoside primers and inhibitors of glycosylation / Jillian R. Brown, Mark M. Fuster, Jeffrey D. Esko -- ch. 35. Carbohydrate-based drug discovery in the battle against bacterial infections : new opportunities arising from programmable one-pot oligosaccharide synthesis / Thomas K. Ritter, Prof. Dr. Chi-Huey Wong.

Carbon Black -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- Titaniium Dioxide -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- Talc Not Containing Asbestiform Fibres -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale.

Overview of CO2 as a contrast agent / Irvin F. Hawkins -- Physical properties and flow dynamics of CO2 / Kyung J. Cho ... [et al.] -- CO2 as a venous contrast agent : safety and tolerance / Kyung J. Cho -- Monitoring patients undergoing CO2 angiography / Grace Peterson and Kyung J. Cho -- Aortogram and runoff / Irvin F. Hawkins -- Visceral CO2 digital subtraction angiography / Kyung J. Cho -- CO2 renal digital subtraction angiography / Irvin F. Hawkins -- CO2 digital subtraction angiography for renal transplant patients / Irvin F. Hawkins -- CO2 digital subtraction angiography of tumors / Kyung J. Cho -- CO2 for traumatic bleeding / Kyung J. Cho -- CO2 for gastrointestinal bleeding / Irvin F. Hawkins -- CO2 for use in iliac arterial lower extremity percutaneous transluminal angioplasty and stent placement / Irvin F. Hawkins -- CO2 renal percutaneous transarterial angioplasty and stent placement / Irvin F. Hawkins -- CO2 upper extremity venography / Kyung J. Cho -- CO2 for wedged hepatic venography / Kyung J. Cho -- CO2 splenoportography / Irvin F. Hawkins -- CO2 with large-needle TIPS / Kyung J. Cho -- CO2 fine-needle transjugular intrahepatic portosystemic shunt / Irvin F. Hawkins -- Aneurysms, arteriovenous malformations, and arteriovenous fistula / Kyung J. Cho -- CO2 inferior vena cavography / Kyung J. Cho -- CO2 with central venous access and venous interventions / Kyung J. Cho, Aya Kamaya, and Seong T. Hahn -- CO2 guided percutaneous nephrostomies including the blunt needle technique / Irvin F. Hawkins -- CO2 plastic bag delivery system / Irvin F. Hawkins -- Potential complications and their prevention / Irvin F. Hawkins.

CT has long been considered an accurate technique in the assessment of cardiac structure and function, but advances in computing power and scanning technology have resulted in its increasing popularity. This book collates all relevant imaging findings of the use of cardiac CT and presents them in a relevant and practical manner.

Pt. I. Imaging modalities. -- The elements of cardiac imaging / Stephen Wilmot Miller -- Echocardiography / Mary Etta E. King and Stefan Mark Nidorf -- Cardiac magnetic resonance imaging / Lawrence M. Boxt -- Cardiac angiography / Stephan Wicky and Stephen Wilmot Miller -- Pt. II. Specific diseases. -- Valvular heart disease / Stephen Wilmot Miller -- Ischemic heart disease / Stephan Wicky and Stephen Wilmot Miller -- Pericardial and myocardial disease / Suhny Abbara and Stephen Wilmot Miler -- Congenital heart disease / Stephen Wilmot Miller -- Thoracic aortic disease / John G. Santilli and Stephen Wilmot Miller.

The elements of cardiac imaging / Stephen Wilmot Miller -- Ethnocardiography / Kaitlyn My-Tu Lam and Mary Etta E. King -- Cardiac magnetic resonance imaging / Amgad N. Makaryus and Lawrence M. Boxt -- Cardiac angiography / Stephen Wilmot Miller -- Cardiac computed tomography / Amgad N. Makaryus and Lawrence M. Boxt -- Valvular heart disease / Anand V. Soni and Stephen Wilmot Miller -- Ischemic heart disease / Stephen Wilmot Miller and Lawrence M. Boxt -- Coronary computed tomography angiography / Suhny Abbara and Stephen Achenbach -- Pericardial and myocardial disease / Suhny Abbara and Stephen Wilmot Miller -- Congenital heart disease / Laureen M. Sena, Lawrence M. Boxt, and Stephen Wilmot Miller -- Thoracic aortic disease / John Guy Santilli and Stephen Wilmot Miller.

Part I. Anatomy and Physiology -- Part II. Physiologic and Pathologic Responses -- Part III. Assessment of Heart Disease -- Part IV. Pathophysiology and Management of Heart Disease -- Part V. Health Promotion and Disease Prevention.

Pacing leads -- The pulse generator -- Modes of pacemaker function -- Implant techniques -- Transvenous left ventricular lead implantation -- Endocardial lead extraction -- Techniques for temporary pacing -- Difibrillator function and implantation -- Sinus node dysfunction -- Acquired atrioventricular block -- Cardiac resynchronization therapy for congestive heart failure -- Pacing therapies for atrical fibrillation -- Pacemakers and syncope -- Indications for implantable cardiovascular defibrillators -- Cardiac device therapy in children -- Cardiac pacing in the critical care setting -- Environmental effects on cardiac pacing systems -- Radiography of implantable arrhythmia management devices -- Follow-up management of the paced patient -- Follow-up of the patient with an implanted cardiac defibrillator.

Overview of the respiratory system / S.C. Wood -- Control of respiration in aquatic vertebrates: Gas transport and gill function in water-breathing fish / S.F. Perry ... [et al.]. Patterns of acid-base regulation during exposure to hypercarbia in fishes / C.J. Brauner and D.W. Baker. Buoyancy control in aquatic vertebrates / B. Pelster. Gas exchange and control of respiration in air-breathing teleost fish / M.L. Glass and F.T. Rantin. Effects of temperature on cardiac function in teleost fish / A.L. Kalinin ... [et al.]. Physiological evidence indicates lungfish as a sister group to the land vertebrates / M.L. Glass. Aestivation in amphibians, reptiles, and lungfish / M.L. Glass, J. Amin-Naves, and G.S.F. da Silva -- Evolution of pulmonary mechaincs and respiratory control: Trade-offs in the evolution of the respiratory apparatus of chordates / S.F. Perry, W. Klein, and J.R. Codd. Environmental selection pressures shaping the pulmonary surfactant system of adult and developing lungs / S. Orgeig and C.B. Daniels. Midbrain structures and control of ventilation in amphibians / L.H. Gargaglioni and L.G.S. Branco. Comparative aspects of hypoxia tolerance of the ectothermic vertebrate heart / H. Gesser and J. Overgaard. Control of the heart and of cardiorespiratory interactions in ectothermic vertebrates / E.W. Taylor and T. Wang. The endocrine-paracrine control of the cardiovascular system / B. Tota and M.C. Cerra. Stoking the brightest fires of life among vertebrates / Raul K. Suarez and Kenneth C. Welch -- Respiratory physiology of birds : metabolic control: Prenatal development of cardiovascular regulation in avian species / J. Altimiras, D.A. Crossley II, and E. Villamor. Control of breathing in birds : implications for high-altitude flight / G.R. Scott and W.K. Milsom -- Mammalian and human physiology: Peripheral chemoreceptors in mammals : structure, function and transduction / P. Kumar. Central chemosensitivity in mammals / L.K. Hartzler and R.W. Putnam. Human exercise physiology / S. Volianitis and Niels H. Secher.

Acute coronary syndromes -- Arrhythmias -- Prevention of bacterial endocarditis -- Congestive heart failure -- Hyperlipidemia -- Hypertension -- Pericardial diseases -- Stable angina -- Valvular disease.

Cardiac symptoms and physical signs -- Congenital heart disease -- Valve disease -- The cardiomyopathies -- Coronary artery disease -- Cardiac failure -- Disturbances of cardiac rhythm -- Pericardial disease -- Infective endocarditis -- Other important cardiac conditions -- The heart in systemic disease -- Cardiac investigations.

Historical development of cardiopulmonary bypass in Minnesota -- The birth of an idea and the development of cardiopulmonary bypass -- Blood pumps in cardiopulmonary bypass -- Principles of oxygenator functions: gas exchange, heat transfer, and operation -- Circuitry and cannulation techniques -- Ultrafiltration and dialysis -- Mechanical circulatory support devices -- Cardiopulmonary bypass for minimally invasive cardiac surgery -- Temperature management in cardiac surgery -- Myocardial protection -- Changes in the pharmacokinetics and pharmacodynamics of drugs administered during cardiopulmonary bypass -- Embolic events -- Endocrine, metabolic, and electrolyte responses -- Cardiopulmonary bypass and the lung -- Immune system and inflammatory responses to cardiopulmonary bypass -- Kidney function and cardiopulmonary bypass -- Splanchnic visceral, metabolic, and glucoregulatory effects of cardiopulmonary bypass -- Neurologic effects of cardiopulmonary bypass -- Hemodilution and priming solutions -- The blood-surface interface -- Hematologic effects and coagulopathy -- Coagulation testing -- Anticoagulation for cardiopulmonary bypass -- Heparin neutralization -- Pharmacologic prophylaxis for post-cardiopulmonary bypass bleeding -- Conduct of cardiopulmonary bypass -- Teamwork: a systems-based practice -- Primum non nocere: patient safety in cardiopulmonary bypass -- Unusual problems in cardiopulmonary bypass -- Termination of cardiopulmonary bypass -- ECMO for respiratory support in adults -- Perfusion for thoracic aortic surgery -- Noncardiac surgical applications of cardiopulmonary bypass -- Pediatric cardiopulmonary bypass overview: state of the art and future -- Myocardial protection and preservation for neonates and infants -- Brain injury following infant cardiac surgery and neuroprotective strategies -- ECMO for infants and children -- Circulatory assist devices for infants and children.

History of the science of cardiopulmonary resuscitation / Mickey S. Eisenberg -- Epidemiology of sudden death / Russell V. Luepker -- Prevention of sudden cardiac death / Joseph E. Marine -- Physiology of ventilation during cardiac arrest / Andrea Gabrielli, A. Joseph Layon, and Ahamed H. Idris -- Management of ventilation during resuscitation / Marsh Cuttino -- Management of airway obstruction / Michael R. Sayre -- Etiology, electrophysiology, myocardial energy mechanics, and treatment of bradyasystole / Charles E. Cady and Tom P. Aufderheide -- Pulseless electrical activity / John M. Field -- Chest compression technique: a neglected key to success in CPR / Charles F. Babbs -- Alternate CPR devices and techniques / Henry Halperin and Barr Rayburn -- Training adults to perform CPR : what works? / Barbara Riegel, Lars Wik, and Alidene Doherty -- External defibrillation / Gregory P. Walcott, Cheryl R. Killingsworth, and Raymond E. Ideker -- Public access defibrillation / Vincent N. Mosesso, Jr., Mary M. Newman, and Kristin R. Hanson -- Pacing during cardiac arrest / Allan S. Jaffe and Utpal H. Pandya -- Therapeutic hypothermia in the treatment of cardiac arrest / Benjamin S. Abella, Terry Vanden Hoek, and Lance B. Becker -- Percutaneous coronary bypass as an adjunct for resuscitation / Catherine Cooper and Bruce D. Spiess -- Principles of drug delivery during CPR / Edgar R. Gonzalez ... [et al.] -- Pharmacological resuscitation interventions / Wanchun Tang, Shijie Sun, and Max Harry Weil --Use of vasopressor drugs / Anette C. Krismer ... [et al.] -- Buffer therapy / Martin von Planta -- Antiarrhythmic drugs and cardiac resuscitation / Brian Olshansky, Pamela Nerheim, and Richard Kerber -- Electrolyte disturbances and cardiopulmonary resuscitation / Domenic A. Sica -- Cardiac arrest in pregnancy / Alison A. Rodriguez and Gary A. Dildy, III -- Drowning / Jerome H. Modell and Andrea Gabrielli -- Cardiopulmonary resuscitation and early management of the lightning strike victim / Mary Ann Cooper and Sara Ashley Johnson -- Hypothermic cardiac arrest / Daniel F. Danzl -- Cardiopulmonary resuscitation in trauma / Rao R. Ivatury and Kevin R. Ward -- Monitoring techniques during resuscitation / Kevin R. Ward, R. Wayne Barbee, and Rao R. Ivatury -- Myocardial dysfunction postresuscitation / Alejandro Vasquez and Karl B. Kern -- Postresuscitation cerebral dysfunction : prevention and treatment / Antonio E. Mu-iz -- Pediatric cardiopulmonary resuscitation / Robert A. Berg and Vinay M. Nadkarni -- In-hospital resuscitation / Mary Ann Peberdy -- Successful systems for out-of-hospital resuscitation / Paul E. Pepe, Lynn A. Roppolo, and Leonard A. Cobb -- Animal models of resuscitation / Kevin R. Ward and R. Wayne Barbee -- Design of clinical trials related to medical emergencies / Alfred Hallstrom -- Ethics in resuscitation / Antonio E. Mu-iz -- The future of cardiopulmonary resuscitation : combination therapy / Joseph P. Ornato.

Part 1. General Aspects of Care -- Invited Commentary / Ronnie A. Rosenthal -- The Epidemiology and Economics of Cardiothoracic Surgery in the Elderly / David A. Etzioni and Vaughn A. Starnes -- Principles of Geriatric Surgery / Mark R. Katlic -- Geriatric Models of Care / Elizabeth A. Capezuti, Patricia Ursomanno, Marie Boltz and Hongsoo Kim -- Delirium After Cardiac Surgery / James L. Rudolph -- Cardiac Rehabilitation in the Elderly / Carl I. Gonzales and Lois A. Killewich -- Legal Aspects of Geriatric Surgery / Marshall B. Kapp -- Ethical Issues in Cardiothoracic Surgery for the Elderly / Susan M. Hecker and Robert M. Sade -- Acute Pain Control in Geriatric Patients After Cardiac and Thoracic Surgeries / Jack M. Berger, Tawfik Ayoub and Jayeshkumar Patel -- Palliative Care in the Elderly / Geoffrey P. Dunn -- Cardiopulmonary Trauma in the Elderly / Jay Menaker and Thomas M. Scalea -- Imaging Features of the Normal Aging Chest / Carol C. Wu and Jo-Anne O. Shepard -- Cardiac Imaging in the Elderly / Faisal Nabi, Dipan J. Shah, Stephen H. Little and Su Min Chang -- Part 2. Physiologic Changes -- Invited Commentary / Michael E. Zenilman -- Biology of Aging / Huber R. Warner -- Hematologic Disorders in the Elderly / Ilene C. Weitz -- Anticoagulation in the Older Surgical Patient / M. Kate Elfrey and Susan J. Zieman -- Medication Usage in Older Cardiothoracic Surgical Patients / Richard A. Marottoli, Sean M. Jeffery and Roshini C. Pinto-Powell -- Wound Healing in the Elderly / Christopher G. Engeland and Praveen K. Gajendrareddy -- Pulmonary Changes in the Elderly / Keenan A. Hawkins and Ravi Kalhan -- Cardiac Changes in the Elderly / Wilbert S. Aronow and William H. Frishman -- Renal Changes in the Elderly / Carlos G. Musso and Dimitrios G. Oreopoulos -- Gastrointestinal and Liver Changes in the Elderly / Vadim Sherman, John A. Primomo and F. Charles Brunicardi --Neurologic and Cognitive Changes in the Elderly / J. Riley McCarten -- Hormonal Changes During and After Cardiac Surgery / Marcello Maggio, Chiara Cattabiani and Gian Paolo Ceda -- Part 3. Cardiac Surgery -- Invited Commentary / William A. Baumgartner -- Preoperative Evaluation and Preparation in the Elderly Cardiac Surgery Patient / Joseph C. Cleveland -- Cardiac Anesthesia in the Elderly / Eric W. Nelson and James H. Abernathy -- Postoperative and Critical Care in the Elderly Cardiac Surgery Patient / Christopher J. Barreiro, Kerry J. Stewart and Glenn Whitman -- Surgery for Ischemic Coronary Disease in the Elderly / Margarita T. Camacho and Melissa L. Wong -- Surgical Treatment of Aortic Valve Disease in the Elderly / Vinod H. Thourani and Robert A. Guyton -- Surgical Treatment of Mitral Valve Disease in the Elderly / Maqsood M. Elahi and Kenton J. Zehr -- Surgical Treatment of Thoracic Aortic Disease in the Elderly / Arnar Geirsson -- Surgical Treatment of Pericardial Disease in the Elderly / Joshua Kindelan and Alberto de Hoyos -- Pacemakers and Implantable Cardioverter Defibrillators in the Elderly / Luciana Armaganijan and Jeff S. Healey -- Heart Transplantation and Mechanical Assistance in the Elderly / Edwin C. McGee -- Part 4. Thoracic Surgery -- Invited Commentary / Joseph LoCicero -- Preoperative Evaluation and Preparation in the Elderly Thoracic Surgery Patient / Ticiana Leal, Noelle K. LoConte, Anai Kothari and Tracey L. Weigel -- Thoracic Anesthesia in the Elderly / Anne C. Kolker -- Postoperative and Critical Care in the Elderly Thoracic Surgery Patient / Brannon R. Hyde and Joseph B. Zwischenberger -- Adjuvant Therapy for Lung Cancer in the Elderly / Jared Weiss and Corey J. Langer -- Pulmonary Surgery for Malignant Disease in the Elderly / Sarah E. Billmeier and Michael T. Jaklitsch -- Benign Thoracic Disease in the Elderly / Rita A. Mukhtar and Pierre R. Theodore -- Lung Transplantation in the Elderly / Juan J. Fibla, Sandra C. Tomaszek and Stephen D. Cassivi -- Esophageal Surgery for Malignant Disease in the Elderly / Philip A. Rascoe and John C. Kucharczuk -- Esophageal Surgery for Benign Disease in the Elderly / Rose E. Hardin, Katie S. Nason and James D. Luketich -- Surgery for Mediastinal Disease in the Elderly / Cameron D. Wright -- Surgery for Pleural Disease in the Elderly / Raja M. Flores and Naveed Z. Alam -- Surgery for Chest Wall Disease in the Elderly / Daniel L. Miller -- Surgery of the Trachea and Bronchi in the Elderly / Douglas J. Mathisen and Ashok Muniappan.

Biomarkers of myocardial necrosis: past, present, and future / Robert H. Christenson and Hassan M.E. Azzazy -- Analytical issues for the clinical use of cardiac troponin / Alan H.B. Wu -- Defining myocardial infarction / Allan S. Jaffe and Luciano Babuin -- Biomarkers in the emergency department: rapid diagnosis and triage / Jin H. Han and W. Brian Gibler -- Cardiac troponin for risk assessment and management of non-ST-elevation acute coronary syndrome / Bertil Lindahl -- Biomarkers of necrosis for risk assessment and management of ST-elevation myocardial infarction / Evangelos Giannitsis and Hugo A. Katus -- Cardiac troponin after revascularization procedures / Warren J. Cantor and L. Kristin Newby -- Biomarkers of necrosis in heart failure: past, present, and future directions / Emil Missov, James Rider, and Leslie Miller -- Is there a role for cardiac troponin and other biomarkers in patients with pulmonary embolism? / Samuel Z. Goldhaber -- Cardiac troponin in conditions other than acute coronary syndromes / Fred S. Apple and David A. Morrow -- Degradation of cardiac troponins: implications for clinical practice / Allan S. Jaffe and Jennifer E. Van Eyk --Clinical use of natriuretic peptides for the diagnosis and management of heart failure / Alan Maisel -- Natriuretic peptides in acute and chronic coronary artery disease / Shuaib M. Abdullah and James A. de Lemos -- Novel markers of hemodynamic stress / Ellen O. Weinberg and Richard T. Lee -- Clinical and research applications of markers of thrombosis / Manesh R. Patel and Richard C. Becker -- Measures of platelet activation and aggregation / Jean-Philippe Collet and Gilles Montalescot -- Monocyte-platelet aggregates in patients with ischemic heart disease / Matthew D. Linden and Mark I. Furman -- Measurement of atherogenic lipoproteins in cardiovascular risk assessment / Richard L. Dunbar and Daniel J. Rader -- Lipoprotein-associated phospholipase A2 and other lipid-related biomarkers in cardiovascular disease / Natalie Khuseyinova and Wolfgang Koenig -- A multimarker approach to evaluation of patients with acute coronary syndrome / David A. Morrow -- Cardiac biomarkers by point-of-care testing / Paul O. Collinson -- Proteomics and cardiovascular biomarker discovery / Emerson Liu and Robert E. Gerszten -- Genetic markers in cardiovascular disease / Marc S. Sabatine.Developing a marker of ischemia: clinical and research challenges / Robert L. Jesse -- Emerging biomarkers of myocardial ischemia / Jesse E. Adams -- Inflammation in cardiovascular disease: the biological basis of inflammatory biomarkers / Peter Libby -- Analytical issues for the clinical use of c-reactive protein / Nader Rifai -- C-reactive protein as a tool for risk assessment in primary prevention / Shari S. Bassuk and Paul M. Ridker -- High-sensitivity c-reactive protein for risk assessment in acute coronary syndromes / Luigi M. Biasucci and Antonio Abbate -- Beyond c-reactive protein: novel markers of vascular inflammation / Christopher Heeschen -- Biomarkers of inflammation: implications in patients with heart failure / Biykem Bozkurt -- Biomarkers of infection and risk of coronary heart disease / Joseph B. Muhlestein -- Biology of the natriuretic peptides / Charlotte Kragelund and Torbjørn Omland -- Analytical issues for the clinical use of b-type natriuretic peptide and n-terminal pro b-type natriuretic peptide / Johannes Mair --

Hyperglycemia and the pathobiology of diabetic complications / Aronson, D. -- Endothelial dysfunction in normal and abnormal glucose metabolism / Esper, R.J. ... [et al.] -- Biomarkers in cardiovascular diabetology: interleukins and matrixins / Fisman, E.Z. ; Adler, Y.; Tenenbaum, A. -- Arterial elasticity in cardiovascular disease: focus on hypertension, metabolic syndrome and diabetes / Cernes, R.; Zimlichman, R.; Shargorodsky, M. -- Hypertension and diabetes / Grossman, E.; Messerli, F.H. -- Impaired glucose metabolism and cerebrovascular diseases / Tanne, D. -- Impact of metabolic syndrome in patients with acute coronary syndrome / Feinberg, M.S.; Schwartz, R.; Behar, S. -- Optimal management of combined dyslipidemia: what have we behind statins monotherapy? / Tenenbaum, A. ... [et al.] -- Non-insulin antidiabetic therapy in cardiac patients: current problems and future prospects / Fisman, E.Z.; Motro, M.; Tenenbaum, A.

v. 1. Genetics -- v. 2. Molecular medicine.

Cardiovascular disease in racial/ethnic minorities: overview and perspectives -- Epidemiology of cardiovascular diseases and risk factors among racial/ethnic populations -- Unmasking racial/ethnic disparities in cardiovascular disease: nutritional, socioeconomic, cultural, and health-care-related contributions -- Race and genetics -- Race, genetics and cardiovascular disease -- Hypertension and stroke in racial/ethnic groups -- Dyslipidemia in racial/ethnic groups -- Novel & emerging risk factors in racial/ethnic groups -- Weight loss interventions to control blood pressure in an increasingly overweight, multi-ethnic society -- Obesity and the cardiometabolic syndrome: impact on chronic kidney disease and CVD -- Risk calculation and clustering within racial/ethnic groups -- Cardiovascular imaging in racial/ethinc populations: implications for the adequate application of cardiovascular imaging techniques guided by racial/ethnical risk factor variations -- Unique aspects of vascular and cardiac ultrasound in racial/ethnical groups -- Heart failure in racial/ethnic group -- Minority women and cardiovascular disease.

Aging of the heart and arteries : relevance to cardiovascular disease / Samer S. Najjar and Edward G. Lakatta -- Frailty : keystone in the bridge between geriatrics and cardiology / William Russell Hazzard -- Cardiovascular risk factors in the elderly : evaluation and intervention / Susan J. Zieman and Beth R. Malasky -- Stable coronary artery disease in the elderly / Beth R. Malasky and Joseph S. Alpert -- Age and mortality and morbidity in ST-segment elevation myocardial infarction / Steven P. Schulman and Gary Gerstenblith -- Unstable angina/non-ST-elevation myocardial infarction in the elderly / Stephen D. Wiviott and Christopher P. Cannon -- Percutaneous coronary intervention in the elderly / Michael J. McWilliams and Eric J. Topol -- Cardiac surgery in the elderly / David D. Yuh and William A. Baumgartner -- Heart failure in the elderly / Michael W. Rich -- Valvular heart disease in the elderly / Milind Y. Desai and Gary Gerstenblith -- Arrhythmia management in the elderly / Jonathan P. Piccini and Hugh Calkins -- Peripheral arterial disease in the elderly / Emile R. Mohler III and William R. Hiatt -- Cardiac rehabilitation in older cardiac patients / Philip A. Ades -- Clinical pharmacology / Janice B. Schwartz -- Medical treatment of the cardiac patient approaching the end of life / Lofty L. Basta, W. Daniel Doty, and Michael D.D. Geldart.

Hemodialysis, from early days to tomorrow / Ritz, E. ... [et al.] -- Mechanisms of solute transport in extracorporeal therapies / Ronco, C., Levin, N.W. -- Machines for hemodialysis / Polaschegg, H.-D. -- Mathematical model to characterize internal filtration / Fiore, G.B., Ronco, C. -- Extracorporeal sensing techniques / Schneditz, D. -- Water treatment for hemodialysis / Cappelli, G. ... [et al.] -- Online convective therapies / Santoro, A. ... [et al.] -- Selected lessons learned from the dialysis outcomes and practice patterns study (DOPPS) / Pisoni, R.L., Greenwood, R.N. -- What did we learn from the hemo study? / Greene, T. -- What are we expecting to learn from the MPO study? / Locatelli, F., Pozzoni, P., Di Filippo, S. -- A new initiative in nephrology: 'kidney disease: improving global outcomes / Lameire, N. ... [et al.] -- Is there a magic in long nocturnal dialysis? / Charra, B. -- Mid-dilution: the perfect balance between convection and diffusion / Santoro, A.; Gaggi, R. ... [et al.] --Sequential hemofiltration-hemodiafiltration technique / Amato, M. ... [et al.] -- Should nephrologists be in charge? / Konner, K. -- Challenges in interventional nephrology / Riella, M.C. -- Vascular access education, planning and percutaneous interventions by nephrologists / Asif, A., Merrill, D., Pennell, P. -- Whole body, single frequency bioimpedance / Piccoli, A. -- Use of segmental multifrequency bioimpedance spectroscopy in hemodialysis / Levin, N.W. ... [et al.] -- Cardiovascular risk in patients with end-stage renal disease / Wang, Y. ... [et al.] -- Improving removal of protein-bound retention solutes / Bammens, B., Evenepoel, P. -- Inflammation in end-stage renal disease / Stenvinkel, P. -- Interaction between nutrition and inflammation in hemodialysis patients / Kuhlmann, M.K., Levin, N.W. -- Monocytes from dialysis patients exhibit characteristics of senescent cells / Carracedo, J. ... [et al.] -- Modifiable risk factors for cardiovascular disease in CKD patients / Seibert, E., Kuhlmann, M.K., Levin, N.W. -- The cardiovascular burden of the dialysis patient / Bowry, S.K., Kuchinke-Kiehn, U., Ronco, C. -- Oxidative stress and reactive oxygen species / Galli, F. ... [et al.] -- Calcium, phosphorus and vitamin D disorders in uremia / Slatopolsky, E., Brown, A., Dusso, A. -- Cardiovascular calcification in end stage renal disease / Raggi, P. -- The mechanism of calcium deposition in soft tissues / Brancaccio, D., Cozzolino, M. -- Biosimilars, generic versions of the first generation of therapeutic proteins / Crommelin, D. ... [et al.] --Electrophysiological response to dialysis / Santoro, A. ... [et al.] -- Noninvasive assessment of vascular function / Schneditz, D., Kenner, T. -- New insights in uremic toxicity / Vanholder, R., Glorieux, G. -- Continuous renal replacement therapy for end-stage renal disease / Gura, V. ... [et al.] -- Slow continuous intravenous plasmapheresis (sciptm) / Handley, H.H. ... [et al.] -- Membraneless dialysis-is it possible? / Leonard, E.F., Cortell, S., Vitale, N.G.

Cardiac connexins: genes to nexus / Duffy, H.S., Fort, A.G., Spray, D.C. -- Physiology of cardiovascular gap junctions / Van Veen, T.A.B., Van Rijen, H.V.M., Jongsma, H.J. -- Role of connexin43-interacting proteins at gap junctions / Giepmans, B.N.G. -- Life cycle of connexins: regulation of connexin synthesis and degradation / Salameh, A. -- Gap junctions and propagation of the cardiac action potential / Bernstein, S.A., Morley, G.E. -- Micropatterns of propagation / Lee, P., Pogwizd, S.M. -- Pharmacology of cardiovascular gap junctions / Hervé, J.-C., Dhein, S. -- Structural and functional coupling of cardiac myocytes and fibroblasts / Camelliti, P., Green, C.R., Kohl, P. -- Connexins and cardiac arrhythmias / Van Rijen, H.V.M. ... [et al.] -- Role of connexins in atrial fibrillation / Dhein, S. -- Connexins in the sinoatrial and atrioventricular nodes / Boyett, M.R. ... [et al.] -- Cardiac ischemia and uncoupling: gap junctions in ischemia and infarction / Dhein, S. -- Connexin 43 and ischemic preconditioning / Schulz, R., Heusch, G. -- Alterations in cardiac connexin expression in cardiomyopathies / Severs, N.J. ... [et al.] -- Alterations of connexin 43 in the diabetic rat heart / Lin, H. ... [et al.] -- Connexins in atherosclerosis / Chadjichristos, C.E., Derouette, J.-P., Kwak, B.R. -- Connexin-dependent communication within the vascular wall: contribution to the control of arteriolar diameter / De Wit, C., Wölfle, S.E., Höpfl, B. -- Cx40 polymorphism in human atrial fibrillation / Hauer, R.N.W. ... [et al.].

Angiotensin II receptor polymorphisms and hypertension / Bruno Baudin -- Angiotensinogen gene polymorphisms and hypertension / Ashok Kumar -- Substitution mapping: using congenic strains to detect genes controlling blood pressure / Bina Joe and Michael R. Garrett -- Local production of angiotensinogen: insights from genetic manipulation of mice / Kamal Rahmouni and Curt D. Sigmund -- Cardiovascular pharmacogenomics / Julie A. Johnson and Larisa H. Cavallari -- Genetic polymorphisms and responses to HMG-CoA, reductase inhibitors / Anke-Hilse Maitland-van der Zee, Olaf H. Klungel, and Anthonius de Boer -- Monogenic causes of heart failure: familial dilated cardiomyopathy / Hideko Kasahara -- Gene therapy vs. pharmacotherapy / Ryuichi Morishita -- Molecular therapeutic approaches for myocardial protection / Alok S. Pachori, Luis G. Melo, and Victor J. Dzau -- Gene transfer and the cardiovascular system / William H. Miller ... [et al.] -- Kallikrein gene transfer in hypertension, cardiovascular and renal disease, and stroke / Julie Chao and Lee Chao -- Current and future novel targets of gene therapy for hypertension / Michael J. Katovich, Justin L. Grobe, and Mohan K. Raizada -- Application of viral gene transfer in studies of neurogenic hypertension / Sergey Kasparov, A.G. Teschemacher, and Julian F.R. Paton -- Vigilant vectors: intelligent gene vectors for cardioprotection in myocardial ischemia / M. Ian Phillips and Yi Tang -- Gene therapy for cerebral arterial diseases / Yoshimasa Watanabe and Donald D. Heistad -- Therapeutic angiogenesis and vasculogenesis for tissue regeneration / Paolo Madeddu -- Cell transplantation: the new frontier / Shafie Fazel ... [et al.] -- Embryonic stem cells and the cardiovascular system / Neta Lavon and Nissim Benvenisty.

What's inside the magnet and why? -- The MRI environment -- Protons and spins: the origin of the MRI signal -- Generating a signal: RF pulses and echoes -- Relaxation times, gradient echoes, and spin echoes -- Making an image: locating and encoding signals in space -- Image space and k-space -- Imaging parameters and image attributes -- Improving SNR with surface coils and array coils -- Pulse sequences and image contrast -- Gradient echo versus spin echo -- Black blood versus bright blood imaging -- Dealing with cardiac motion: how do we image the beating heart? -- Dealing with respiratory motion -- Fast imaging: how do we speed up the image acquisition? -- Special pulse sequences for cardiac imaging -- Common artifacts -- The basics of a CMR study -- Components of CMR protocols -- Anatomy of CMR -- The CMR report -- Diseases of the aorta -- Cardiomyopathies -- Pericardial disease -- Cardiac masses -- Valvular heart disease -- Ischemic heart disease -- Basic adult congenital heart disease (ACHD) -- Pulmonary vein assessment -- Interventional cardiovascular magnetic resonance imaging.

Introduction / edited by Peter Mathes -- Exercise testing in heart disease / edited by Helmut Gohlke -- Exercise training in heart disease / edited by Helmut Gohlke -- Nutrition / edited by Catherine Monpère -- Tobacco addiction / edited by Irene Hellemans -- Psychological and behavioral support / edited by Hannah McGee -- Social and caring support / edited by Philippe Sellier -- Adapted programs for special groups / edited by Hugo Saner -- Pharmacotherapy, organization, evaluation / edited by Joep Perk.

1. History of cardiovascular epidemiology -- 2. General principles -- 3. Study designs -- 4. Principles of study design and measurement -- 5. Data sources -- 6. Conducting the research -- 7. Mortality surveillance -- 8. Morbidity surveillance -- 9. Population surveys -- Glossary -- List of appendices 1-37 (on CD Rom).

Development of the cardiovascular system -- Transcription factors in cardiovascular development -- Vascular biology -- Tumor angiogenesis -- Genetics and genomics of the cardiovascular system -- Regulation of the heart -- Heart disease and failure -- Hypertension, atherosclerosis, and lipid homeostasis -- Repairing the cardiovascular system -- Author index -- Subject index.

Who are the uninsured? / Howard Eng -- Why are people uninsured? ; The culture of poverty and the uninsured ; Health disparities and the uninsured ; Providers of care for the uninsured ; Chronic disease and the uninsured ; Medical homes (preferably "health home") and the uninsured / Nancy J. Johnson -- Medication assistance for the uninsured / Nancy J. Johnson and Janet S. Smith -- Medically uninsured refugees and immigrants / Lane P. Johnson -- Medically uninsured and the homeless / Jennifer Vanderleest -- Care of underserved people with mental illness / Francisco A. Moreno and Sarah Heron -- Medically uninsured older Americans / Lynne Tomasa -- Direct caregivers association: an option for a rapidly growing aging population? / Judith B. Clinco -- The rural uninsured ; Dental care for the uninsured / Lane P. Johnson -- Uninsured children at school / Fran Bartholomeaux and Nancy J. Johnson -- Building community collaborations around care for the uninsured / Nancy J. Johnson -- Information technology and medically uninsured / Theresa Cullen -- The role of government in providing health care to the uninsured / James E. Dalen -- Think nationally, act locally / Lane P. Johnson.

Examines the relationship between being insured or uninsured and the health of American Adults.

"Carotenoids are of great interest due to their essential biological functions in both plants and animals. However, the properties and functions of carotenoids in natural systems are surprisingly complex. With an emphasis on the chemical aspects of these compounds, Carotenoids: Physical, Chemical, and Biological Functions and Properties presents a broad overview and recent developments with respect to understanding carotenoid structure, electronic and photochemical properties, and the use of novel analytical methods in the detection and characterization of carotenoids and their actions. The text also explores LC/MS and LC/MS/MS techniques as well as new applications of PCR and molecular biology methodologies"--Book jacket.

Obstructive carotid artery disease and evidence-based benefits of revascularization / Alfredo M. Lopez-Yunez and Jose Biller -- Historical background: 25 years of endovascular therapy for obstructive carotid artery disease / Klaus Mathias -- Evidence-based efficacy in preventing stroke / Sumaira Macdonald, Trevor J. Cleveland, and Peter A. Gaines -- The global carotid artery stent registry / Michael H. Wholey, Nadim Al-Mubarak, Mark H. Wholey -- Current indications of carotid artery stenting / Nadim Al-Mubarak and Gary S. Roubin -- Recurrent stenosis following carotid endarterectomy / Nadim Al-Mubarak and Gary S. Roubin -- The role of multispecialty groups in carotid artery stenting / Michael H. Wholey -- Basic angiographic anatomy of the brachiocephalic vasculature / Nadim Al-Mubarak and Jiri J. Vitek -- Carotid artery access techniques / Nadim Al-Mubarak ... [et. al] -- Procedural techniques / Sriram S. Iyer ... [et. al] -- The direct cervical carotid artery approach / Edward B. Diethrich -- Procedural complications / Nadim Al-Mubarak -- The risk of embolization during carotid stenting and the concept of anti-embolization / Takao Ohki -- Microembolization during carotid artery stenting / Nadim Al-Mubarak -- Carotid artery stenting with the distal occlusion anti-embolization system / Michel Henry [et. al] -- Intravascular filter anti-embolization systems / Goran Stankovic and Antonio Colombo -- The proximal balloon catheter: the parodi anti-emboli system / Mark C. Bates and Juan Carlos Parodi -- Anti-embolizaton protection: illustrative cases and technical pearls / Francesco Liistro and Antonio Colombo -- Restenosis following carotid artery stenting / Fayaz Shawl -- Limitations of current equipment and the future carotid artery stenting device / Horst Sievert and Kasja Rabe -- Elective angioplasty and stenting for intracranial atherosclerotic stenoses / H. Christian Schumacher [et. al] -- Current status of clinical trials and implication of anti-emboli protection / Brajesh K. Lal and Robert W. Hobson II -- Statistical and experimental design issues in the evaluation of carotid artery stenting / George Howard, Brent J. Shelton, and Virginia J. Howard -- Clinical investigations and protocols / Christina M. Brennan, Pallavi Kumar, and Gary S. Roubin.

A simple and reliable assay of proteoglycan synthesis by cultured chondrocytes -- Assays of proteoglycan and collagen degradation in cultures of rabbit cartilage explants -- Production of antibodies against degradative neoepitopes in aggrecan -- Immunoassays for collagens in chondrocyte and cartilage explant cultures -- Detection of apoptosis in cartilage in situ and in isolated chondrocytes -- Expression, activity, and regulation of MAP kinases in cultured chondrocytes -- Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain -- In vitro physical stimulation of tissue-engineered and native cartilage --v. 1. Cellular and molecular tools. Culture and phenotyping of chondrocytes in primary culture -- Culture of chondrocytes in alginate beads -- Immortalization of human articular chondrocytes for generation of stable, differentiated cell lines -- Culture of immortalized chondrocytes and their use as models of chondrocyte function -- Generation of pluripotent stem cells and their differentiation to the chondrocytic phenotype -- Semiquantitative analysis of gene expression in cultured chondrocytes by RT-PCR -- Quantification of mRNA expression levels in articular chondrocytes with PCR technologies -- RNA extraction from cartilage -- Gene expression analysis in cartilage by in situ hybridization -- Analysis of differential gene expression in healthy and osteoarthritic cartilage and isolated chondrocytes by microarray analysis -- High-efficiency nonviral transfection of primary chondrocytes -- In vitro gene transfer to chondrocytes and synovial fibroblasts by adenoviral vectors -- Changes of chondrocyte metabolism in vitro: an approach by proteomic analysis -- Analysis of chondrocyte functional markers and pericellular matrix components by flow cytometry --v. 2. Structure and in vivo analysis. Generation and use of transgenic mice as models of osteoarthritis -- Development and clinical application in arthritis of a new immunoassay for serum type IIA procollagen NH2 propeptide -- Histological and immunohistological studies on cartilage -- Histochemical visualization of the cartilage hyaladherins using a biotinylated hyaluronan oligosaccharide bioaffinity probe -- Methods for cartilage and subchondral bone histomorphometry -- Laser-mediated microdissection as a tool for molecular analysis in arthritis -- Analysis of protein distribution in cartilage using immunofluorescence and laser confocal scanning microscopy -- Molecular and biochemical assays of cartilage components -- Mechanical characterization of native and tissue-engineered cartilage -- Noninvasive study of human cartilage structure by MRI -- High-resolution MRI techniques for studies in small-animal models -- High-resolution imaging of osteoarthritis using microcomputed tomography -- High-resolution ultrasonograpy for analysis of age- and disease-related cartilage changes -- Evaluation of cartilage composition and degradation by high-resolution magic-angle spinning nuclear magnetic resonance -- Pulsed-field gradient-nuclear magnetic resonance (PFG NMR) to measure the diffusion of ions and polymers in cartilage: applications in joint diseases -- Dynamics of collagen in articular cartilage studied by solid-state NMR methods -- Computerized protocol for anatomical and functional studies of joints.

Articular cartilage : structure, biology, and function / Kyle R. Flik ... [et al.] -- Evaluating outcome following cartilage procedures / Robert G. Marx -- MRI and articular cartilage : evaluating lesions and postrepair tissue / Hollis G. Potter, Li F. Foo, and Andrew D. Pearle -- Decision making in cartilage repair procedures / Riley J. Williams III and Robert H. Brophy -- Nonoperative treatment options for symptomatic cartilage lesions / Marc C. Drakos and Answorth A. Allen -- Marrow stimulation and microfracture for the repair of articular cartilage lesions / Daniel J. Solomon, Riley J. Williams III, and Russell F. Warren -- Cartilage repair with chitosan-glycerol phosphate-stabilized blood clots / Michael D. Buschmann ... [et al.] --Autologous osteochondral transplantation / Anthony Miniaci, Clinton Jambor, and Frank A. Petrigliano -- Articular cartilage resurfacing using synthetic resorbable scaffolds / Riley J. Williams III and Gabriele G. Niederauer -- Autologous chondrocyte implantation / Deryk G. Jones and Lars Peterson -- Osteochondral allograft transplantation / Joseph Yu and William D. Bugbee -- Matrix-induced autologous chodrocyte implantation / David Wood and Ming Hao Zheng -- Cell-based cartilage repair using the hyalograft transplant / Maurilio Marcacci ... [et al.] --Allogeneic chodrocyte-based cartilage repair using alginate beads / Peter C.M. Verdonk ... [et al.] -- The role of knee osteotomy in the setting of articular cartilage repair / Keith M. Baumgarten and Thomas L. Wickiewicz -- Management of osteochondritis dissecans / Mininder S. Kocher and Joseph J. Czarnecki -- Meniscus transplantation and cartilage resurfacing : considerations, indications, and approach / Scott A. Rodeo -- Articular cartilage repair strategies in the ankle joint / Monika Volesky, Timothy Charlton, and Jonathan T. Deland -- Management of cartilage injuries in the hip / Bryan T. Kelly, Patrick P. Sussman, and Robert L. Buly -- Rehabilitation strategies following articular cartilage surgery in the knee / John T. Cavanaugh.

Mapping and mapmaking --Medical mapping: early histories --Mapping and statistics: 1830-1849 -- John Snow: the London epidemics -- The cholera debate -- Map as intent: variations on John Snow -- Mapping legacy -- Public health: the divorce -- Disease ecologies: disease atlases -- Complex processes: diffusion and structure -- GIS and medical mapping -- Map thinking: an afterward.

Unit I: General principles of toxicology -- History and scope of toxicology / Michael A. Gallo -- Principles of toxicology / David L. Eaton and Steven G. Gilbert -- Mechanisms of toxicity / Zoltán Gregus -- Risk assessment / Elaine M. Faustman and Gilbert S. Omenn -- Unit II: Disposition of toxicants -- Absorption, Distribution, and excretion of toxicants / Lois D. Lehman-McKeeman -- Biotransformation of xenobiotics / Andrew Parkinson and Brian W. Ogilvie -- Toxicokinetics / Danny D. Shen -- Unit III: Non-organ-directed toxicity -- Chemical carcinogens / James E. Klaunig and Lisa M. Kamendulis -- Genetic toxicology / R. Julian Preston and George R. Hoffmann -- Developmental toxicology / John M. Rogers and Robert J. Kavlock -- Unit IV: Target organ toxicity -- Toxic responses of the blood / John C. Bloom and John T. Brandt -- Toxic responses of the immune system / Norbert E. Kaminski ... [et al.] -- Toxic responses of the liver / Hartmut Jaeschke -- Toxic responses of the kidney / Rick G. Schnellmann -- Toxic responses of the respiratory system / Hanspeter R. Witschi ... [et al.] -- Toxic responses of the nervous system / Virginia C. Moser ... [et al.] -- Toxic responses of the ocular and visual system / Donald A. Fox and William K. Boyes -- Toxic responses of the heart and vascular system / Y. James Kang -- Toxic responses of the skin / Robert H. Rice and Theodora M. Mauro -- Toxic responses of the reproductive system / Paul M.D. Foster and L. Earl Gray Jr. -- Toxic responses of the endocrine system / Charles C. Capen -- Unit V: Toxic agents -- Toxic effects of pesticides / Lucio G. Costa -- Toxic effects of metals / Jie Liu, Robert A. Goyer, and Michael P. Waalkes -- Toxic effects of solvents and vapors / James V. Bruckner, S. Satheesh Anand, and D. Alan Warren -- Health effects of radiation and radioactive materials / Naomi H. Harley -- Properties and toxicities of animal venoms / John B. Watkins, III -- Toxic effects of plants / Stata Norton -- Unit VI: Environmental toxicology -- Air pollution / Daniel L. Costa -- Ecotoxicology / Richard T. Di Giulio and Michael C. Newman -- Unit VII: Applications of toxicology -- Food toxicology / Frank N. Kotsonis and George A. Burdock -- Analytic/forensic toxicology / Alphonse Poklis -- Clinical toxicology / Louis R. Cantilena Jr. -- Occupational toxicology / Peter S. Thorne.

Developing case conceptualizations and treatment plans -- The complexity of human experience -- Behavioral case conceptualizations and treatment plans -- Cognitive case conceptualizations and treatment plans -- Feminist case conceptualizations and treatment plans -- Emotion-focused case conceptualizations and treatment plans -- Dynamic case conceptualizations and treatment plans -- Family systems case conceptualizations and treatment plans -- Constructivist case conceptualizations and treatment plans -- Transtheoretical case conceptualizations and treatment plans -- Discussion and extension of the model.

"A case-based book organized by the top 10 common complaints of patients presenting to emergency departments. This approach allows the reader to learn the pathophysiology of the major diseases, and analyze each case in a way that more closely approximates the clinical practice of medicine; not knowing which organ system is damaged or compromised before examining the patient. The cases are based on real patients and the diseases are either common in emergency practice, or are dangerous diagnoses not to be missed. The case descriptions include questions regarding the patient's presentation and basic information about the disease, illustrating key elements from the history, physical, and when necessary ancillary studies that help lead to a diagnosis. Each chapter ends with a flow diagram showing how diseases of different organ systems can present with similar initial complaints. This book is an ideal resource for medical students, residents and trainees in emergency medicine"--Provided by publisher.

Physics and Artifacts -- Basic Ultrasound Views -- Quantification of Left Ventricular Size and Wall Thickness -- Quantification of Left Ventricular Systolic Function -- Noninvasive Hemodynamic Assessment -- Echocardiographic Assessment of Diastolic Dysfunction (DD) and Heart Failure with Normal EF (HFnlEF) -- Tissue Doppler Imaging and Strain Echocardiography -- Transesophageal Echocardiography -- Intraoperative Transesophageal Echocardiography -- Use of Echo Contrast in Routine Practice -- Three-Dimensional Echocardiography -- Stress Echocardiography --Mechanical Dyssynchrony Assessment -- Post Cardiac Resynchronization Therapy (CRT) Optimization Protocol -- Echocardiographic Assessment of the Right Ventricle -- Aortic Valve Stenosis and Regurgitation -- Mitral Prolapse Regurgitation and Mitral Stenosis -- Right-Sided Heart Valves Assessment in Disease -- The Assessment of Prosthetic Valve Function -- The Aorta: Diseases of the Aorta -- Hypertrophic Cardiomyopathy -- Stress Cardiomyopathy -- Pericardial Diseases -- Atrial Septal Defect -- Percutaneous Interventions for Congenital Heart Defects -- Cardiac Tumors and Masses -- Cardiac Transplantation -- Vascular Imaging.

From case investigation to the case-control method : information for decision making -- Problem investigation and inferences using the case-control method -- Avoiding bias in case and control selection -- Avoiding information bias in exposure assessment -- Alternative case based designs -- Analysis of case-control data -- Applications : outbreak investigation -- Genetic epidemiology for case-based designs -- Applications : evaluation -- Applications : evaluation of screening programs -- Other applications.

This casebook has been developed as a teaching tool for instructors and workshop leaders rather than as a textbook for students or workshop participants. There is no need for participants to have copies of the casebook: facilitators can provide participants with individual case studies and chapter introductions relevant to the research ethics topic being addressed. Individual case studies and chapter introductions relevant to the research ethics topic being addressed can be photocopied from the print version or downloaded from the WHO web site without additional permission from WHO, unless the planned use is in conjunction with commercial purposes.

Genitourinary tract infections -- Respiratory tract infections -- Gastrointestinal tract infections -- Skin and soft tissue infections -- Central nervous system infections -- Systemic infections -- Emerging and reemerging infections.

The concept of cat primary visual cortex / Bertram R. Payne and Alan Peters -- Optical imaging of functional architecture in cat primary visual cortex / Mark Hubener and Tobias Bonhoeffer -- 2-Deoxyglucose architecture of cat primary visual cortex / Siegrid Lowel -- Functional mapping in the cat primary visual cortex using high magnetic fields / Dae-Shik Kim, Timothy Q. Duong, Kamil Ugurbil, and Seong-Gi Kim -- Relationships of LGN afferents and cortical efferents to cytochrome oxidase blobs / Joanne A. Matsubara and Jamie D. Boyd -- Influence of topography and ocular dominance on the functional organization of callosal connections in cat striate cortex / Jaime F. Olavarria -- Essential and sustaining LGN inputs to cat primary visual cortex / Theodore G. Weyand -- Integration of thalmic inputs to cat primary visual cortex / R. Clay Reid, Jose-Manuel Alonso, and W. Martin Usrey -- The emergence of direction selectivity in cat primary visual cortex / Allen L. Humphrey and Alan B. Saul -- Long-range intrinsic connections in cat primary visual cortex / Kerstin E. Schmidt and Siegrid Lowell -- Pharmacological studies on receptive field architecture / Ulf T. Eysel -- Orientation selectivity and its modulation by local and long-range connections in visual cortex / David Somers, Valentin Dragoi, and Mriganka Sur -- Response synchronization, gamma oscillations, and perceptual binding in cat primary visual cortex / Wolf Singer -- The special relationship between B Retinal ganglion cells and cat primary visual cortex / Bertram R. Payne and R. Jarrett Rushmore -- Primary visual cortex within the cortico-cortico-thalmic network / Jack W. Scannell and Malcolm P. Young -- Behavioral analyses of the contributions of cat primary visual cortex to vision / Donald E. Mitchell -- Index.

1Introduction and general issues --2Tools, facilities, and the operating team --3Anesthesia for cataract surgery --4Preparation for surgery --5Wound placement and construction --6Viscoelastics --7Capsulorrhexis and capsule problems --Hydrodissection --9Nuclear strategies --10Irrigation-aspiration --11Lens implantation and its history --12Postoperative care --13Adjuncts for and management of complex cases --14Management of complications --15Lens exchange including refractive lens exchange --16Wavefront aberrometry and cataract surgery.

Part I. Cataract Surgery -- Approach to Cataract Surgery in Glaucoma Patients / Graham A. Lee and Ivan Goldberg -- Anesthesia / Marlene R. Moster and Augusto Azuara-Blanco -- Management of the Small Pupil / Cynthia Mattox -- Small Incision Cataract Surgery and Glaucoma / Brooks J. Poley, Richard L. Lindstrom, Thomas W. Samuelson, and Richard R. Schulze Jr. -- Elevated Intraocular Pressure After Cataract Surgery / Parag A. Gokhale and Emory Patterson -- Part II. Combined Surgery -- Combined Cataract and Trabeculectomy Surgery / Sandra M. Johnson -- Managing Cataract and Glaucoma in the Developing World - Manual Small Incision Cataract Surgery (MSICS) Combined with Trabeculectomy / Rengaraj Venkatesh, Rengappa Ramakrishnan, Ramasamy Krishnadas, Parthasarathy Sathyan, and Alan L. Robin -- Antimetabolite-Augmented Trabeculectomy Combined with Cataract Extraction for the Treatment of Cataract and Glaucoma / Sumit Dhingra and Peng Tee Khaw -- Early Postoperative Bleb Maintenance / Robert T. Chang and Donald L. Budenz -- Laser Suture Lysis and Releasable Sutures / Anastasios Costarides and Prathima Neerukonda -- Cataract Surgery Combined with Glaucoma Drainage Devices / Ramesh S. Ayyala and Brian J. Mikulla -- Choroidal Detachment Following Glaucoma Surgery / Diego G. Espinosa-Heidmann -- Cataract Extraction Combined with Endoscopic Cyclophotocoagulation / Steven D. Vold -- Approach to Cataract Extraction Combined with New Glaucoma Devices / Diamond Y. Tam and Iqbal Ike K. Ahmed -- Part III. Glaucoma Conditions -- Cataract Surgery in Patients with Exfoliation Syndrome / Anastasios G.P. Konstas, Nikolaos G. Ziakas, Miguel A. Teus, Dimitrios G. Mikropoulos, and Vassilios P. Kozobolis -- Cataract Surgery in the Presence of a Functioning Trabeculectomy Bleb / Hylton R. Mayer and James C. Tsai -- Cataract Extraction in Eyes with Prior GDD Implantation / Ramesh Ayyala and Brian Mikulla -- Cataract Surgery in the Primary Angle-Closure Patient / Jimmy S.M. Lai -- Nanophthalmos / Carlos Gustavo Vasconcelos de Moraes and Remo Susanna Jr. -- Cataract Induced Glaucoma: Phacolytic/Phacomorphic / Sandra M. Johnson -- Glaucoma Related to Pseudophakia / Junping Li and Jason Much -- Cataract and Glaucoma in Retinopathy of Prematurity / Anthony J. Anfuso and M. Edward Wilson -- Cataract Surgery in the Hypotonous Eye / Devon Ghodasra and Sandra M. Johnson.

Pt. 1 Evaluation -- Pt. 2 Preparation -- Pt. 3 Extracapsular cataract extraction -- Pt. 4 Phacoemulsification -- Pt. 5 Special techniques for cataract extraction -- Pt. 6 Intraocular lenses -- Pt. 7 Management of complications -- Pt. 8 Innovations and future trends for cataract extraction -- Index.

Probability models -- One-way classification -- Models for 2 x 2 contingency tables -- The general I x J contingency table -- Log-linear models for contingency tables -- Strategies for log-linear model selection -- Models for binary responses -- Logit and multinomial response models -- Models in ordinal contingency tables -- Analysis of doubly classified data -- Analysis of repeated measures data -- Table of the chi-squared distribution.

pt. 1. The study of disasters -- pt. 2. Causes of disasters -- pt. 3. Behavioral consequences of disasters -- pt. 4. Our models : applying a public health perspective.

Lipid rafts, caveolae, and GPI linked proteins / Valerie L. Reeves, Candice M. Thomas, and Eric J. Smart -- Caveolae and the regulation of endocytosis / Anna L. Kiss -- Caveolin : role in cell signaling / Cecile Boscher and Ivan Robert Nabi -- Regulation of ENOS in caveolae / Chieko Mineo and Philip W. Shaul -- Recent developments in the interactions between caveolin and pathogens / Fabiana S. Machado ... [et al.] -- Caveolin and breast cancer : a new clinical perspective / Isabelle Mercier and Michael P. Lisanti -- Caveolin and prostate cancer progression / Michael R. Freeman, Wei Yang, and Dolores Di Vizio -- Caveolins and caveolae, roles in insulin signalling, and diabetes / Peter Strolfors -- Atherosclerosis, caveolae, and caveolin / Stephanos Pavlides ... [et al.] -- Caveolins and heart diseases / Mathivadhani Panneerselvam, Hemal H. Patel, and David M. Roth -- Caveolins and lung function / Nikolaos A. Maniatis ... [et al.].

Organization of This Book -- Clinical Documentation -- The HL7 Clinical Document Architecture -- Extensible Markup Language -- Basic Data Types -- Text and Multimedia -- Demographic Data -- Codes and Vocabularies -- Codes -- Dates and Times -- Collections -- HL7 Version 3 Modeling -- Clinical Document Infrastructure -- The CDAtm Header -- The CDAtm Body -- Clinical Statements in the CDAtm -- HL7 Version 2 to CDAtm Release 2 -- Extracting Data from a CDAtm Document -- Templates -- Validating the Content of a CDAtm Document -- Implementation Guides on CDAtm.

cDNA preparation -- Gene identification -- Patterns of mRNA expression -- Functional relationship among cDNA translation products.

Early embryonic cell fate decisions in the mouse / Yojiro Yamanaka and Amy Ralston -- Nuclear architecture in stem cells / Kelly J. Morris, Mita Chotalia, and Ana Pombo -- Epigenetic regulation of pluripotency / Eleni M. Tomazou and Alexander Meissner -- Autosomal lyonization of replication domains during early mammalian development / Ichiro Hiratani and David M. Gilbert -- Preservation of genomic integrity in mouse embryonic stem cells / Peter J. Stambrook and Elisia D. Tichy -- Transcriptional regulation in embryonic stem cells / Jian Chien, Dominic Heng, and Huck Hui Ng -- Alternative splicing in stem cell self renewal and differentiation / David A. Nelles and Gene W. Yeo -- MicroRNA regulation of embryonic stem cell self renewal and differentiation / Collin Melton and Robert Blelloch -- Telomeres and telomerase in adult stem cells and pluripotent embryonic stem cells / Rosa M. Marión and Maria A. Blasco -- X chromosome inactivation and embryonic stem cells / Tahsin Stefan Barakat and Joost Gribnau -- Adult stem cells and their niches / Francesca Ferraro, Cristina Lo Celso, and David Scadden -- Adult stem cell differentiation and trafficking and their implications in disease / Ying Zhuge, Zhao-Jun Liu, and Omaida C. Velazquez -- Vertebrates that regenerate as models for guiding stem cells / Christopher L. Antos and Elly M. Tanaka -- Reprogramming of somatic cells to pluripotency / Masato Nakagawa and Shinya Yamanaka.

ch. 1. Cells and Tissues, p. 1-18 -- ch. 2. From Water to DNA: The Chemistry of Life, p. 19-49 -- ch. 3. Membranes and Organelles, p. 51-63 -- ch. 4. DNA Structure and the Genetic Code, p. 65-85 -- ch. 5. DNA as a Data Storage Medium, p. 87-103 -- ch. 6. Transcription and the Control of Gene Expression, p. 105-127 -- ch. 7. Recombinant DNA and Genetic Engineering, p. 129-161 -- ch. 8. Manufacturing Protein, p. 163-181 -- ch. 9. Protein Structure, p. 183-211 -- ch. 10. Intracellular Protein Trafficking, p. 213-235 -- ch. 11. How Proteins Work, p. 237-256 -- ch. 12. Energy Trading within the Cell, p. 257-280 -- ch. 13. Metabolism, p. 281-308 -- ch. 14. Ions and Voltages, p. 309-324 -- ch. 15. The Action Potential, p. 325-340 -- ch. 16. Intracellular Signaling, p. 341-362 -- ch. 17. Intercellular Communication, p. 363-379 -- ch. 18. Mechanical Molecules, p. 381-400 -- ch. 19. Cell Cycle and Control of Cell Number, p. 401-422 -- ch. 20. Case Study: Cystic Fibrosis, p. 423-435 -- Appendix: Channels and Carriers, p. 437-440.

Cell cycle molecules and mechanisms of the budding and fission yeasts / Tim Humphrey and Amanda Pearce -- The plant cell cycle: an overview / John H. Doonan -- The C. elegans cell cycle: overview of molecules and mechanisms / Sander van den Heuvel -- Developmental control of growth and cell cycle progression in drosophila / Lisa Swanhart, Jeremy Kupsco, and Robert J. Duronio -- The xenopus cell cycle: an overview / Anna Philpott and P. Renee Yew -- The mammalian cell cycle: an overview / Jane V. Harper and Gavin Brooks -- Synchronization of cell populations in G₁/S and G₂/M phases of the cell cycle / Jane V. Harper -- Mapping origins of DNA replication in eukaryotes / Susan A. Gerbi -- In situ assay for analyzing the chromatin binding of proteins in fission yeast / Stephen E. Kearsey ... [et al.] -- Application of magnetic beads to purify cells transiently transfected with plasmids encoding short hairpin RNAs / Peter D. Adams --Polo-like kinase-1: activity measurement and RNAi-mediated knockdown / Marcel A.T.M. van Vugt and René H. Medema -- The Ipl1/aurora kinase family: methods of inhibition and functional analysis in mammalian cells / Claire Ditchfield, Nicholas Keen, and Stephen S. Taylor -- Purification of the Ndc80 kinetochore subcomplex from xenopus eggs / Mark L. McCleland and P. Todd Stukenberg.The cell cycle and virus infection / Steven R. Emmett ... [et al.] -- Methods for preparation of proteins and protein complexes that regulate the eukaryotic cell cycle for structural studies / Julie Welburn and Jane Endicott -- E2F transcription factors and pRb pocket proteins in cell cycle progression / Ludger Hauck and Rüdiger von Harsdorf -- Forkhead (FOX) transcription factors and the cell cycle: measurement of DNA binding by foxO and foxM transcription factors / Katrina A. Bicknell -- Measurement of geminin activity in xenopus egg extracts / Thomas J. McGarry -- CDK-activating kinases: detection and activity measurements / Stéphane Larochelle and Robert P. Fisher -- Cyclins, cyclin-dependent kinases, and cyclin-dependent kinase inhibitors: detection methods and activity measurements / Gavin Brooks -- Measurement of wee kinase activity / Paul R. Mueller and Walter F. Leise -- CDC25 dual-specificity protein phosphatases: detection and activity measurements / Sorab N. Dalal and Melanie Volkening -- Assaying cell cycle checkpoints: activity of the kinase chk1 / Carmela Palermo and Nancy C. Walworth --

The biology of cyclins and cyclin-dependent protein kinases: an introduction / Lucio Miele -- In situ immunofluorescence analysis: immunofluorescence microscopy / Amjad Javed ... [et al.] -- In situ immunofluorescence analysis: analyzing RNA synthesis by 5-bromouridine-5'-triphosphate labeling / Amjad Javed ... [et al.] -- Immunofluorescence analysis using epitope-tagged proteins: in vitro system / Amjad Javed ... [et al.] -- Analysis of in vivo gene expression using epitope-tagged proteins / Amjad Javed ... [et al.] -- Chromatin immunoprecipitation / Amjad Javed ... [et al.] --Protein-deoxyribonucleic acid interactions linked to gene expression: electrophoretic mobility shift assay / Amjad Javed ... [et al.] -- Protein-deoxyribonucleic acid interactions linked to gene expression: DNase I digestion / Amjad Javed ... [et al.] -- Protein-deoxyribonucleic acid interactions linked to gene expression: ligation-mediated polymerase chain reaction / Amjad Javed ... [et al.] -- Assays for cyclin-dependent kinase inhibitors / Adrian M. Senderowicz -- Protein degradation via the proteosome / Henry Hoff, Hong Zhang, and Christian Sell --The transformed phenotype / Henry Hoff ... [et al.] -- A morphologic approach to detect apoptosis based on electron microscopy / Martyn K. White and Caterina Cinti -- Detection of apoptotic deoxyribonucleic acid break by in situ nick translation / Carmela Trimarchi ... [et al.] -- Induction of deoxyribonucleic acid damage by alkylating agents / Salvatore Cortellino ... [et al.] -- Induction of deoxyribonucleic acid damage by γ irradiation / Salvatore Cortellino, David P. Turner and Alfonso Bellacosa -- Ultraviolet irradiation of cells / David P. Turner, Anthony T. Yeung, and Alfonso Bellacosa -- Transient production of retroviral- and lentiviral-based vectors for the transduction of mammalian cells / Tiziana Tonini ... [et al.] --Determination of functional viral titer by drug-resistance colony assay, expression of green fluorescent protein, and β-galactoside staining / Tiziana Tonini ... [et al.] -- Retroviral and lentiviral vector titration by the analysis of the activity of viral reverse transcriptase / Tiziana Tonini ... [et al.] -- Single and double colloidal gold labeling in postembedding immunoelectron microscopy / Nicoletta Zini ... [et al.] -- Multifluorescence labeling and colocalization analyses / Massimo Riccio ... [et al.].

Methodological considerations in the evaluation of cell cycle in the central nervous system / Richard A. Prayson -- Neural stem cells / Philippe Taupin -- Progenitors and precursors of neurons and glial cells / Monika Bradl -- Vaculogenesis and angiogenesis / Gerald A. Grant and Damir Janigro -- Neuronal migration and malformation of cortical development / Giorgio Battaglia and Stefania Bassanini -- Genome-wide expression profiling of neurogenesis in relation to cell cycle exit / P. Roy Walker ... [et al.] -- Neurogenesis and apoptotic cell death / Klaus van Leyen ... [et al.] -- Ion channels and cell cycle / Annarosa Arcangeli and Andrea Becchetti -- Nonsynaptic GABAergic communication and postnatal neurogenesis / Xiuxin Liu, Anna Bolteus, and Angélique Bordey -- Critical roles of Ca2+ and K+ homeostasis in apoptosis / Shan Ping Yu -- Mammalian neural stem-cell renewal / Yvan Arsenijevic -- Methods of determining apoptosis in neuro-oncology: review of the literature / Brian T. Ragel ... [et al.] -- Cell cycle, neurological disorders, and reactive gliosis / Kerri L. Hallene and Damir Janigro -- Potassium channels, cell cycle and tumorigenesis in the central nervous system / Gabriele Dini, Erin V. Ilkanich, and Damir Janigro -- Enhanced neurogenesis following neurological disease / Philippe Taupin -- Endothelial injury and cell cycle re-entry / Ljiliana Krizanac-Bengez -- The contribution of bone marrow-derived cells to cerebrovascular formation and integrity / David Kobiler and John Glod -- Microvessel remodeling in cerebral ischemia / Danica B. Stanimirovic, Maria J. Moreno, and Arsalan S. Haqqani -- Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders / Lieve Moons, Peter Carmeliet, and Mieke Dewerchin -- Epidermal growth factor receptor in the adult brain / Carmen Estrada and Antonio Villalobo -- Neurodegeneration and loss of cell cycle control in postmitotic neurons / Randall D. York, Samantha A. Cicero, and Karl Herrup -- Cell cycle activation and the amyloid-[beta] protein in Alzheimer's disease / Katarzyna A. Gustaw ... [et al.] -- Neuronal precursor proliferation and epileptic malformations of cortical development / Jorge A González-Martínez, William E. Bingaman, and Imad M. Najm -- Vascular differentiation and cell cycle / Luca Cucullo -- Adult neurogenesis and central nervous system cell cycle analysis: novel tools for exploration of the neural causes and correlates of psychiatric disorders / Amelia J. Eisch and Chitra D. Mandyam -- Neurogenesis and Alzheimer's disease: compensation, crisis, or chaos? / Gemma Casadesus ... [et al.] -- P53 and multidrug resistance transporters in the central nervous system / Shirley Teng and Micheline Piquette-Miller -- Signaling modules in glial tumors and implications for molecular therapy / Gurpreet S. Kapoor and Donald M. O'Rourke -- Detection of proliferation in gliomas by positron emission tomography imaging / Alexander M. Spence ... [et al.] -- Transition of normal astrocytes into a tumor phenotype / Sean E. Aeder and Isa M. Hussaini -- Mechanisms of gliomagenesis / Wei Zhang and Howard A. Fine -- Cell cycle of encapsulated cells / Roberto Dal Toso and Sara Bonsiegna -- Viral vector delivery to dividing cells / Yoshinaga Saeki -- Electrical stimulation and angiogenesis: electrical signals have direct effects on endothelial cells / Min Zhao -- Development and potential therapeutic aspects of mammalian neural stem cells / L. Bai, S.L. Gerson, and R.H. Miller -- Mammalian Sir2 proteins: a role in epilepsy and ischemia / Barbara Aumayr and Damir Janigro.

Brief description of the histological, cytological and functional aspects of the ovary / María Luisa Escobar, Gerardo H. Vázquez-Nin, and Olga M. Echeverría -- Embryonic development of the ovary, sexual reproduction and meiosis / Gerardo H. Vázquez-Nin, María Luisa Escobar, and Olga M. Echeverría -- Development of the ovary in the embryo, infancy, childhood, pre-puberty and puberty / Gerardo H. Vázquez-Nin ... [et al.] -- Apoptosis / María Luisa Escobar, Gerardo H. Vázquez-Nin, and Olga M. Echeverría -- Autophagy / María Luisa Escobar, Gerardo H. Vázquez-Nin, and Olga M. Echeverría -- Oncosis / María Luisa Escobar, Gerardo H. Vázquez-Nin, and Olga M. Echeverría -- Necrosis / Gerardo H. Vázquez-Nin, María Luisa Escobar, and Olga M. Echeverría -- Programmed cell death in fetal oocytes / Francesca Gioia Klinger and Massimo De Felici -- DNA damage and apoptosis in fetal and ovarian reserve oocytes / Massimo De Felici and Francesca Gioia Klinger -- Prefollicular cells / María Luisa Escobar, Gerardo H. Vázquez-Nin, and Olga M. Echeverría -- Prepubertal oocytes / Gerardo H. Vázquez-Nin, María Luisa Escobar, and Olga M. Echeverría -- Follicular cells / María Luisa Escobar, Gerardo H. Vázquez-Nin, and Olga M. Echeverría -- Follicular atresia in adult animals / Gerardo H. Vázquez-Nin, María Luisa Escobar, and Olga M. Echeverría -- Luteolysis / Gerardo H. Vázquez-Nin, María Luisa Escobar, and Olga M. Echeverría.

Preface / John E. Johnson, Peter K. Vogt -- Flock House Virus: A model system for understanding non-enveloped virus entry and membrane penetration / Amy Odegard, Manidipa Banerjee and John. E. Johnson -- The calciviruses / Umesh Katpally and Thomas J. Smith -- Picornaviruses / Tobias J. Tuthill ... [et al.] -- From touchdown to transcription: The reovirus cell entry pathway / Pranav Danthi ... [et al.] -- Rotavirus cell entry / Matthew Baker and B.V. Venkataram Prasad -- Structures and functions of parvovirus capsids and the process of cell infection / Colin R. Parrish -- Cellular entry of polyomaviruses / Billy Tsai and Mengding Qian -- Adenovirus / Jason G. Smith ... [et al.].

Pt. 1. Cell fusion -- 1. Yeast mating, a model system for studying cell and nuclear fusion / Casey A. Ydenberg, Mark D. Rose -- 2. Cell fusion in the filamentous fungus, neurospora crassa / André Flei€ner, Anna R. Simonin, N. Louise Glass -- 3. Gametic cell adhesion and fusion in the uicellular alga chlamydomonas / Nedra F. Wilson -- 4. Cell Fusion in caenorhabditis elegans / Scott Alper, Benjamin Podbilewicz -- 5. Myoblast fusion in drosophila / Susan M. Abmayr, Shufei Zhuang, and Erika R. Geisbrecht -- 6. Mammalian fertilization is dependent on multiple membrane fusion events / Paul M. Wassarman, Eveline S. Litscher -- 7. Molecular control of mammalian myoblast fusion / Katie M. Jansen, Grace K. Pavlath -- 8. Placenta trophoblast fusion / Berthold Huppertz, Marcus Borges -- 9. Macrophage fusion / Agnès Vignery -- Pt. 2. Cell fusion assays -- 10. Cell fusion assays for yeast mating pairs / Eric Grote -- 11. Ultrastructural analysis of cell fusion in yeast / Alison E. Gammie -- 12. Isolation and in vitro binding of mating type plus fertilization tubules from chlamydomonas / Nedra F. Wilson -- 13. Optical imaging of cell fusion and fusion proteins in caenorhabditis elegans / Star Ems, William A. Mohler -- 14. Ultrastructural imaging of cell fusion in caenorhabditis elegans / Star Ems, William A. Mohler -- 15. Live imaging of drosophila myoblast fusion / Brian E. Richardson, Karen Beckett, Mary K. Baylies -- 16. Ultrastructural Analysis of myoblast fusion in drosophila / Shiliang Zhang, Elizabeth H. Chen -- 17. Genomic approach to myoblast fusion in drosophila / Beatriz Estrada, Alan M. Michelson -- 18. Mesenchymal cell fusion in the sea urchin embryo / Paul G. Hodor, Charles A. Ettensohn -- 19. Sperm-egg fusion assay in mammals / Naokazu Inoue, Masaru Okabe -- 20. Quantitative assays for cell fusion / Jessica H. Shinn-Thomas, Victoria L. Scranton, William A. Mohler -- 21. Fusion assays and models for the trophoblast / Sascha Drewlo, ... [et al.] -- 22. Methods to fuse macrophages in vitro / Agnès Vignery.

1.Introduction /Thomas Dittmar and Kurt S. Zänker --2.Heterochronic control of AFF-1-mediated cell-to-cell fusion in C. elegans /Lilach Friedlander-Shani and Benjamin Podbilewicz --3.Role of SNAREs in membrane fusion /Bhanu P. Jena --4.Molecular and cellular mechanisms of mammalian cell fusion /Xiaofeng Zhou and Jeffrey L. Platt --5.Membrane fusions during mammalian fertilization /Bart M. Gadella and Janice P. Evans --6.Trophoblast fusion /Berthold Huppertz and Martin Gauster --7.Macrophage fusion and multinucleated giant cells of inflammation /Amy K. McNally and James M. Anderson --8.Molecular mechanisms of myoblast fusion across species /Adriana Simionescu and Grace K. Pavlath --9.Cell-fusion-mediated reprogramming : pluripotency or transdifferentiation? : implications for regenerative medicine /Daniela Sanges, Frederic Lluis, and Maria Pia Cosma --10.Cell fusion and tissue regeneration /Manuel Álvarez-Dolado and Magdalena Martínez-Losa --11.Dendritic cell-tumour cell fusion vaccines /Walter T. Lee.

Introduction / Thomas Dittmar and Kurt S. Zänker -- Horizontal Gene Transfers with or without Cell Fusions in All Categories of the Living Matter / Joseph G. Sinkovics -- Class III Viral Membrane Fusion Proteins / Marija Backovic and Theodore S. Jardetzky -- Human Trophoblast in Trisomy 21: A Model for Cell - Cell Fusion Dynamic Investigation / André Malassiné, Guillaume Pidoux, Pascale Gerbaud, Jean Louis Frendo and Danièle Evain-Brion -- Cell Fusion and Hyperactive Osteoclastogenesis in Multiple Myeloma / Franco Silvestris, Sabino Ciavarella, Sabino Strippoli and Franco Dammacco -- Cell Fusion Hypothesis of the Cancer Stem Cell / Xin Lu and Yibin Kang -- Expression of Macrophage Antigens by Tumor Cells / Ivan Shabo and Joar Svanvik -- Leukocyte-Cancer Cell Fusion: Initiator of the Warburg Effect in Malignancy? / Rossitza Lazova, Ashok Chakraborty and John M. Pawelek -- Cell Fusion, Drug Resistance and Recurrence CSCs / Christa Nagler, Kurt S. Zänker and Thomas Dittmar -- The Role of Microvesicles in Malignancies / Erna Pap.

Forging the Factory: Ribosome Synthesis and Growth Control in Budding Yeast / P. Jorgensen, M. Tyers, and J.R. Warner -- Control of rRNA and tRNA Production Is Closely Tied to Cell Growth / R.J. White -- Autophagy: Reversing Cell Growth / Y. Ohsumi -- Synaptic Growth, Synaptic Maintenance, and the Persistence of Long-term Memory Storage / C.H. Bailey, R.D. Hawkins, and E.R. Kandel -- The Control of Synaptic Function by Local Protein Synthesis and Degradation / W.B. Smith, B. Bingol, G.N. Patrick, and E.M. Schuman -- Lymphocyte Growth / D.E. Bauer and C.B. Thompson -- Modulating Skeletal Muscle Hypertrophy and Atrophy: Signaling Pathways and Therapeutic Targets / D.J. Glass and G.D. Yancopoulos -- Mechanisms Controlling Heart Growth in Mammals / J.R. McMullen and S. Izumo -- Regulation of Cell Growth in the Endocrine Pancreas / K. Roovers and M.J. Birnbaum -- Plant Cell Growth / B. Menand and C. Robaglia.How Metazoans Reach Their Full Size: The Natural History of Bigness / P.H. O'Farrell -- Growth and Cell Cycle Control in Drosophila / B.A. Edgar and H.F. Nijhout -- Coordination of Cell Growth and Cell-cycle Progression in Proliferating Mammalian Cells / I. Conlon, A. Lloyd, and M. Raff -- Coordination of Cell Growth and Cell Division / E.V. Schmidt -- TOR Signaling in Yeast: Temporal and Spatial Control of Cell Growth / R. Loewith and M.N. Hall -- Growth Regulation by Insulin and TOR Signaling in Drosophila / S.J. Leevers and E. Hafen -- Growth Control through the mTOR Network / D.A. Guertin, D.-H. Kim, and D.M. Sabatini -- IGF-I Receptor Signaling in Cell Growth and Proliferation / R. Baserga -- S6K Integrates Nutrient and Mitogen Signals to Control Cell Growth / J. Montagne and G. Thomas -- Translation Initiation and Cell Growth Control / E. Petroulakis and N. Sonenberg --

Molecular beacons: fluorescent probes for detection of endogenous mRNAs in living cells -- Second-harmonic imaging of collagen -- Visualizing calcium signaling in cells by digitized wide-field and confocal fluorescent microscopy -- Multifluorescence labeling techniques and confocal laser scanning microscopy on lung tissue -- Evaluation of confocal microscopy system performance -- Quantitative analysis of atherosclerotic lesion composition in mice -- Applications of microscopy to genetic therapy of cystic fibrosis and other human diseases -- Laser scanning cytometry: principles and applications -- Near-clinical applications of laser scanning cytometry -- Laser capture microdissection -- Analysis of asbestos-induced gene expression changes in bronchiolar epithelial cells using laser capture microdissection and quantitative reverse transriptase-polymerase chain reaction -- New approaches to fluorescence in situ hybridization -- Microarray image scanning -- Near-field scanning optical microscopy in cell biology and cytogenetics -- Porosome: the fusion pore revealed by multiple imaging modalities -- Secretory vesicle swelling by atomic force microscopy -- Imaging and probing cell mechanical properties with the atomic force microscopy -- Reflection contrast microscopy: the bridge between light and electron microscopy -- Three-dimensional analysis of single particles by electron microscopy: sample preparation and data acquisition -- Three-dimensional reconstruction of single particles in electron microscopy: image processing -- A new microbiopsy system enables rapid preparation of tissue for high-pressure freezing.

Mammalian cell lines command an effective monopoly for the production of therapeutic proteins that require post-translational modifications. This book deals with the methodology involved in the development of cell lines and the cell engineering approach that can be employed to enhance productivity and improve cell function.

ch. 1. Introduction: History of Red Cell Membrane Research, p. 1-25 -- ch. 2. Composition of Normal Red Cell Membranes, p. 27-46 -- ch. 3. Stereotactic Structure of Red Cell Membranes, p. 47-59 -- ch. 4. Skeletal Proteins, p. 61-80 -- ch. 5. Integral Proteins, p. 81-113 -- ch. 6. Anchoring Proteins, p. 115-132 -- ch. 7. Membrane Morphogenesis in Erythroid Cells, p. 133-154 -- ch. 8. States of Methylation in the Promoter of the Genes of β-Spectrin, Band 3, and Protein 4.2, p. 155-164 -- ch. 9. Disease States of Red Cell Membranes: Their Genotypes and Phenotypes, p. 165-172 -- ch. 10. Hereditary Spherocytosis (HSp. 173-212 -- ch. 11. Hereditary Elliptocytosis (HEp. 213-237 -- ch. 12. Hereditary Stomatocytosis, p. 239-249 -- ch. 13. Acanthocytosis and Its Related Disorders, p. 251-260 -- ch. 14. Abnormalities of Skeletal Proteins, p. 261-296 -- ch. 15. Abnormalities of Integral Proteins and Blood Group Antigens, p. 297-332 -- ch. 16. Abnormalities of Anchoring Proteins, p. 333-378 -- ch. 17. Abnormalities of Membrane Lipids, p. 379-414 -- ch. 18. Closing remarks, p. 415-416.

The migrating cell / Entschladen, F., Zänker, K.S. -- Stem cell migration in health and disease / Dittmar, T. ... [et al.] -- Leukocyte motility and human disease / Cooper, K., Nuzzi, P., Huttenlocher, A. -- Coordination of leukocyte polarity and migration / Martín-Cófreces, N.B., Serrador, J.M., Sánchez-Madrid, F. -- Positioning phosphoinositide 3-kinase in chemokine and antigen-dependent T-lymphocyte navigation mechanisms / Ward, S.G. -- Migration of functionally specialized T-helper cells : TFH cells, Th17 cells, and FoxP3+ T cells / Kim, C.H. -- ADAMs and ectodomain proteolytic shedding in leukocyte and tumour cell migration / Ager, A., Knäuper, V., Poghosyan, Z. -- Guided tour of cell migration : signals and pathways / Ratke, J., Lang, K. -- Regulation of the E-cadherin adhesion complex in tumor cell migration and invasion / Menke, A., Giehl, K. -- The cytoskeletal connection : understanding adaptor proteins / Ziegler, W.H. -- Locomotor force generation by myosins / Jbireal, J.M.A., Entschladen, F., Zänker, K.S.

ch. 1.Molecular mechanisms regulating actin filament dynamics at the leading edge of motile cells /Thomas D. Pollard --ch. 2.The Role of talin and myosin VII in adhesion - a FERM connection /Margaret A. Titus --ch. 3.Do class I myosins exert their functions through regulation of actin dynamics? /Thierry Soldati and Claudia Kistler --ch. 4.Ephrin-regulated contact repulsion of growth cones /Lene K. Harbott, Daniel J. Marston and Catherine D. Nobes --ch. 5.Interplay between the actin cytoskeleton, focal adhesions and microtubules /Christoph Ballestrem, Natalia Magid, Julia Zonis, Michael Shtutman and Alexander Bershadsky --ch. 6.Initial steps from cell migration to cell-cell adhesion /Jason S. Ehrlich, W. James Nelson and Marc D. H. Hansen --ch. 7.Using bioprobles to follow protein dynamics in living cells /Mark R. Holt, Daniel Y. H. Soong, James Monypenny, Ian M. Dobbie, Daniel Zicha and Graham A. Dunn --ch. 8.Actin filament assembly: the search for a barbed end /Craig F. Stovold, Stewart J. Sharp and Laura M. Machesky --ch. 9.Role of WASp family proteins in cytoskeletal reorganization and cell motility /Tadaomi Takenawa, Shiro Suetsugu --ch. 10.Regulation and function of the small GTP-binding protein ARF6 in membrane dynamics /Thierry Dubois, Emma Colucci-Guyon, Florence Niedergang, Magali Prigent and Philippe Chavrier --ch. 11.Chemotaxis of cancer cells during invasion and metastasis /John Condeelis, Xiaoyan Song, Jonathan M. Backer, Jeffrey Wyckoff and Jeffrey Segall --ch. 12.Dynamin and cytoskeletal-dependent membrane processes /James D. Orth, Noah W. Gray, Heather M. Thompson and Mark A. McNiven --ch. 13.Regulation of microtubule dynamics in migrating cells: a new role for Rho GTPases /Torsten Wittmann and Clare M. Waterman-Storer --ch. 14.Calpain regulation of cell migration /Anna Huttenlocher --ch. 15.Role of villin in the dynamics of actin microfilaments /Rafika Athman, Sylvie Robine and Daniel Louvard --ch. 16.Scar, WASp and the Arp2/3 complex in dictyostelium migration /Simone Blagg and Robert Insall --ch. 17.Directional sensing: subcellular targeting of GPCR downstream effectors during chemotaxis /Satoru Funamoto and Richard A. Firtel --ch. 18.Cell crawling, cell behaviour and biomechanics during convergence and extension /Ray Keller and Lance Davidson --ch. 19.Regulation of cell mirgration in vitro and in vivo /Donna J. Webb, Karen Donais, Shin-Ichi Murase, Hannelore Asmussen and Alan F. Horwitz] --ch. 20.Genes that control cell mirgration during mouse development /Carmen Birchmeier.

Sect. I. Biophysical chemistry, metabolism, second messengers, and ultrastructure. Biophysical chemistry of physiological solutions / Jeffrey c. Freedman -- Physiological structure and function of proteins / Matthew R. Pincus -- Cell membranes / Jeffrey C. Freedman -- Ionophores in planar lipid bilayers / Jeffrey C. Freedman -- Cell structure / Michael S. Forbes -- Signal transduction and second messengers / Aldebaran M. Hofer -- Calcium as an intracellular second messenger: mediation by calcium-binding proteins / John R. Dedman and Marcia A. Kaetzel -- Sect. II. Membrane potential, transport physiology, pumps, and exchangers. Diffusion and permeability / Nicholas Sperelakis and Jeffrey C. Freedman -- Origin of resting membrane potentials / Nicholas Sperelakis -- Gibbs-Donnan equilibrium potentials / Nicholas Sperelakis -- Mechanisms of carrier-mediated transport: facilitated diffusion, cotransport and countertransport / Steven M. Grassl -- Active ion transport by ATP-driven ion pumps / Robert A. Farley -- Ca2+ -ATPases / Tracy J. Pritchard, Istvan Edes and Evangelia G. Kranias -- Na+ -Ca2+ exchange currents / John H.B. Bridge, Natalia S. Torres and Michela Ottolia --Intracellular chloride regulation / Francisco J. Alvarez-Leefmans -- Osmosis and regulation of cell volume / Clive M. Baumgarten and Joseph J. Feher -- Intracellular pH regulation / Robert W. Putnam -- Sect. III. Membrane excitability and ion channels. Cable properties and propagation of action potentials / Nicholas sperelakis -- Electrogenesis of membrane excitability / Nicholas Sperelakis -- Patch-clamp techniques / Laura Conforti -- Structure and mechanism of voltage-gated ion channels / Simon Rock Levinson and William A. Sather -- Biology of gap junctions / Richard D. Veenstra -- Regulation of cardiac ion channels by cyclic nucleotide-dependent phosphorylation / Gordon M. Wahler and Nicholas Sperelakis -- Direct regulation of ion channels by GTP-binding proteins / Atsushi Inanobe and Yoshihisa Kurachi -- Developmental changes in ion channels / Takeshi Kobayashi ... [et al.] --Regulation of ion channel localization and activity through interactions with the cytoskeleton / Stephen Lambert -- Why are so many ion channels mechanosensitives? / Catherine E. Morris -- Sect. IV. Ion channels as targets for toxins, drugs, and genetic diseases. Ion channels as targets for toxins / Kenneth M. Blumenthal -- Ion channels as targets for drugs / Seth Robey, Kevin J. Sampson and Robert S. Kass -- Inherited diseases of ion transport / Robert A. Farley -- Sect. V. Synaptic transmission and sensory transduction. Ligand-gated ion channels / Kenneth R. Tovar and Gary L. Westbrook -- Synaptic transmission / Janusz B. Suszkiw -- Excitation-secretion coupling / Nicole Gallo-Payet and Marcel Daniel Payet -- Stimulus-response coupling in metabolic sensor cells / Stan Misler -- Cyclic nucleotide-gated ion channels / Anita L. Zimmerman -- Sensory receptors and mechanotransduction / Andrew S. French and Päivi H. Torkkeli -- Acoustic transduction / Daniel C. Marcus -- Visual transduction / Anita L. Zimmerman -- Gustatory and olfactory sensory transduction / Stephen D. Roper -- Infrared sensory organs / Stephen D. Roper and Michael S. Grace --Electroreceptors and magnetoreceptors / Timothy C. Tricas and Bruce A. Carlson -- Sect. VI. Muscle and other contractile systems. Skeletal muscle excitability / Nicholas Sperelakis, Judith Heiny and Hugo gonzalez-Serratos -- Cardiac action potentials / Gordon M. Wahler -- Smooth muscle excitability / Neil D. Detweiler ... [et al.] -- Excitation-contraction coupling in skeletal muscle / Judith A. Heiny and Gerhard Meissner -- Contraction of muscles: mechanochemistry / Richard J. Paul -- Flagella, cilia, actin- and centrin-based movement / Kenneth W. Foster -- Electrocytes of electric fish / Anthony L. Gotter, Marcia A. Kaetzel and John R. Dedman -- Sect. VII. Protozoa and bacteria. Physiological adaptations of protists / Michael Levandowsky -- Physiology of prokaryotic cells / Dennis W. Grogan -- Sect. VIII. Specialized processes: photosynthesis and bioluminescence. Photosynthesis / Darrell Fleischman -- bioluminescence / J. Woodland Hastings.

Heme oxygenase-1 and carbon monoxide in vascular regulation / Stefan W. Ryter and Augustine M.K. Choi -- Tumor necrosis factor-[alpha]/receptor signaling through the Akt kinase / Osman Nidai Ozes ... [et al.] -- Protein modifications by nitric oxide and reactive nitrogen species / Harry Ischiropoulos -- Redox signaling in hypoxic pulmonary vasoconstriction / E. Kenneth Weir ... [et al.] -- cGMP-dependent protein kinase in regulation of the perinatal pulmonary circulation / Usha Raj ... [et al.] -- Glutamate receptor activation in the pathogenesis of acute leg injury / Sami I. Said -- Carboxyl methylation of small GTPases and endothelial cell function / Sharon Rounds, Elizabeth O. Harrington, and Qing Lu -- Pressure-induced inflammatory signaling in lung endothelial cells / Wolfgang M. Kuebler -- Regulation of endothelial barrier function: contributions of the transcellular and paracellular pathways / Dolly Mehta, Richard D. Minshall, and Asrar B. Malik -- Sphingolipid signaling: implications for vascular biology / Margaret M. Harnett -- Regulations of cytokine signaling / Bao Q. Vuong ... [et al.] -- Cell signaling by vasoactive agents / Barry L. Fanburg ... [et al.] -- Reactive oxygen species and cell signaling in lung ischemia / Aron B. Fisher --Pulmonary vascular barrier regulation by thrombin and Edg receptors / Jeffrey R. Jacobson and Joe G.N. Garcia -- Second-messenger signaling in lung capillaries / Kaushik Parthasarathi -- Plasma membrane-to-nucleus calcium signaling / Giles E. Hardingham -- Signaling by mitochondria / Navdeep S. Chandel -- Pro-inflammatory signaling by endothelial focal complexes in lung / Sunita Bhattacharya -- Hydrogen peroxide as intracellular messenger: production, target, and elimination / Sue Goo Rhee ... [et al.] -- Calcium-inhibited adenylyl cyclase (AC6) controls endothelial cell barrier function / Troy Stevens.

Part 1. Regulatory. -- Regulation of Cell Product Manufacturing and Delivery: A United States Perspective / R.W. Lindblad -- The Regulatory Situation for Academic Cell Therapy Facilities in Europe / I. Slaper-Cortenbach, M. Scott, D. Herrmann, M. Introna and K. Theunissen, et al. -- A Regulatory System for Cell and Tissue Therapies: Proposed Approach in Australia / A. Farrugia -- Part 2. GMP Facility Design. -- University of Minnesota - Molecular and Cellular Therapeutics (MCT) / D.H. McKenna -- University of Pittsburgh Cancer Institute - Hematopoietic Stem Cell Laboratory (HSC Lab)/Immunological Monitoring and Cellular Products Laboratory (IMCPL) / D.L. Griffin, A.D. Donnenberg and T.L. Whiteside / Baylor College of Medicine - Center for Cell and Gene Therapy (CAGT) / A. Gee -- Design of a New GMP Facility - Lessons Learned / A. Gee -- Part 3. Professional Cell Therapy Standards. -- AABB Cell Therapy Standards / Z.M. Szczepiorkowski and E. Nunes -- Professional Standards for Cellular Therapies: Foundation for the Accreditation of Cellular Therapy (FACT) / P.I. Warkentin -- Part 4. Facility Operations -- Standard Operating Procedures / C.G. Lindgren -- Staffing, Training, and Competency / D.M. Kadidlo -- Cleaning Procedures / A. Gee and D.L. Lyon -- Environmental Monitoring / A. Gee and D.L. Lyon -- Supply Management / A. Gee and C.M. Rooney -- Facility Equipment / D.L. Griffin -- Quality / J.W. Atkins -- Product Manufacturing / A. Gee -- Product Review, Release, and Administration / N.H. Collins -- Use of a Facility Master File to Facilitate Regulatory Submissions for Cell Therapy Products / E.J. Read and H.M. Khuu.

Current views of the embryonic and neural stem cell : cell replacement or molecular repair? / Roya Sabetrasekh ... [et al.] -- Developing novel cell sources for transplantation in Parkinson's disease / Nicolaj S. Christophersen ... [et al.] -- Neural transplantation in the nonhuman primate model of Parkinson's disease / Kimberly B. Bjugstad and John R. Sladek, Jr. -- Cell-based therapy for Huntington's disease / Claire M. Kelly, Stephen B. Dunnett, and Anne E. Rosser -- Use of bone marrow stem cells as therapy for behavioral deficits in rodent models of Huntington's disease / Gary L. Dunbar, Justin D. Oh-Lee, and Laurent Lescaudron -- Human neuroteratocarcinoma cells as a neural progenitor graft source for cell transplantation in stroke / Cesario V. Borlongan ... [et al.] --Therapeutic applications of bone marrow-derived stem cells in neurologic injury and disease / C. Dirk Keene ... [et al.] -- Cell therapy for models of pain and traumatic brain injury / Mary Eaton and Jacqueline Sagen -- The use of sertoli cells in neural transplantation / Dwaine F. Emerich, Cesario V. Borlongan, and Craig Halberstadt -- The choroids plexus : a novel graft source for neural transplantation / Cesario V. Borlongan ... [et al.] -- Progress and challenges in immunoisolation for CNS cell therapy / Christopher G. Thanos and Dwaine F. Emerich -- Evidence-based methodology for advancing neural reconstruction / Stephen Polgar -- Hematopoietic cell therapy for brain repair / Martina Vendrame and Alison E. Willing -- Stem cells and regenerative medicine : commercial and pharmaceutical implications / L. Eduardo Cruz and Silvia P. Azevedo.

Cell-Based Microarrays: Overview / Ella Palmer -- Cell-Based Co-transfection Microarrays for Use with HEK293T Cells on a Poly d-Lysine-Coated Polystyrene Microplate / Meenal Soni, Fang Lai -- Large-Scale Cell-Based Microarrays and Their Use with HEK293T Cells and Downstream Apoptotic Assays / Ella Palmer, Tom C. Freeman -- A Novel Fluorescent Transcriptional Reporter for Cell-Based Microarray Assays / Tanya M. Redmond, Michael D. Uhler -- High-Throughput Subcellular Protein Localization Using Transfected-Cell Arrays: Subcellular Protein Localization Using Cell Arrays / Yuhui Hu, Michal Janitz -- Cell Arrays for the Measurement of Organelle Dynamics in Living Cells / Holger Erfle, Tautvydas Lisauskas, Christoph Claas, Jürgen Reymann, Vytaute Starkuviene -- High-Throughput Immunofluorescence Microscopy Using Yeast Spheroplast Cell-Based Microarrays / Wei Niu, G. Traver Hart, Edward M. Marcotte -- Cell-Based Microarrays of Infectious Adenovirus Encoding Short Hairpin RNA (shRNA) / Hansjürgen Volkmer, Frank Weise -- Reverse Transfected Cell Microarrays in Infectious Disease Research / Andreas Konrad, Ramona Jochmann, Elisabeth Kuhn, Elisabeth Naschberger, Priya Chudasama, Michael Stürzl -- Transfected Cell Microarrays for the Expression of Membrane-Displayed Single-Chain Antibodies / Baochuan Lin, James B. Delehanty -- Blood Cell Capture on Antibody Microarrays and Monitoring of the Cell Capture Using Surface Plasmon Resonance Imaging / Yoann Roupioz, Sarah Milgram, André Roget, Thierry Livache -- Immobilized Culture and Transfection Microarray of Non-adherent Cells / Satoshi Yamaguchi, Erika Matsunuma, Teruyuki Nagamune -- Plasma Polymer and PEG-Based Coatings for DNA, Protein and Cell Microarrays / Andrew L. Hook, Nicolas H. Voelcker, Helmut Thissen -- Polymer Microarrays for Cellular High-Content Screening / Salvatore Pernagallo, Juan J. Diaz-Mochon -- High-Throughput Analyses of Gene Functions on a Cell Chip by Electroporation / Koichi Kato, Hiroo Iwata -- Microfluidic Image Cytometry / Ken-ichiro Kamei, Jing Sun, Hsian-Rong Tseng, Robert Damoiseaux.

Cell-cell channels and their implications for cell theory / Frantisek Baluska, Dieter Volkmann, and Peter W. Barlow -- Mating cell-cell channels in conjugating bacteria / Elisabeth Grohmann -- The tetrahymena conjugation junction / Eric S. Cole -- Cytoplasmic bridges in volvox and its relatives / Harold J. Hoops, Ichiro Nishii, and David L. Kirk -- Vegetative hyphal fusion in filamentous fungi / Nick D. Read and M. Gabriela Roca -- Plasmodesmata: cell-cell channels in plants / Yoselin Benitez Alfonso, Laurence Cantrill, and David Jackson -- Sieve-pore plugging mechanisms / Aart J.E. van Bel -- Actin and myosin VIII in plant cell-cell channels / Jozef Samaj ... [et al.] -- Cell-cell communication in wood / John R. Barnett -- TMV movement protein targets cell-cell channels in plants and prokaryotes: possible roles of tubulin- and FtsZ-based cytoskeletons / Manfred Heinlein -- Viral movement proteins induce tubule formation in plant and insect cells / Jan W.M. van Lent and Corinne Schmitt-Keichinger --Cell-cell movements of transcription factors in plants / Alexis Maizel -- Gap junctions: cell-cell channels in animals / Fabio Mammano -- Tunneling nanotubes: membranous channels between animal cells / Hans-Hermann Gerdes and Amin Rustom -- Cytoplasmic bridges as cell-cell channels of germ cells / Sami Ventelä -- Fusome as a cell-cell communication channel of drosophila ovarian cyst / Jean-René Huynh -- Cytonemes as cell-cell channels in human blood cells / Svetlana Ivanovna Galkina .. [et al.] -- Paracellular pores in endothelial barriers / Luca Manzi and Gianfranco Bazzoni -- Channels across endothelial cells / Radu V. Stan -- Molecular transfers through transient lymphoid cell-cell channels / Mary Poupot, Julie Gertner, and Jean-Jacques Fournié -- Cell-cell transport of homeoproteins: with or without channels / Alain Joliot and Alain Prochiantz -- Virological synapse for cell-cell spread of viruses / Eduardo Garcia and Vincent Piguet -- Cell-cell fusion: transient channels leading to plasma membrane merger / William A. Mohler.

Analysis of mammallian sperm-egg membrane interactions during in vitro fertilization / Genevieve B. Wortzman, Allison J. Gardner, and Janice P. Evans -- Collagen gel contraction assay / Peter Ngo ... [et al.] -- Methods to assess tissue permeability / Juan C. Ibla and Joseph Khoury -- Bacterial-bacterial cell interactions in biofilms: detection of polysaccharide intercellular adhesins by blotting and confocal microscopy / Kimberly K. Jefferson and Nuno Cerca -- A biochemical method for tracking cholera toxin transport from plasma membrane to golgi and endoplasmic reticulum / Heidi E. DeLuca and Wayne I. Lencer -- Isolation and culture of murine heart and lung endothelial cells for in vitro model systems / Yaw-Chyn Lim and Frances W. Luscinskas --Blood-brain barrier and cell-cell interactions: methods for establishing in vitro models of the blood/brain barrier and transport measurements / Michael Aschner ... [et al.] -- Interactions of intestinal epithelial cells with bacteria and immune cells: methods to characterize microflora and functional consequences / Geraldine Canny, Alexander Swidsinski, and Beth A. McCormick --Expression cloning of signaling proteins regulated by cell adhesion / Michelle L. Matter and Joe W. Ramos -- Assays for the calcium sensitivity of desmosomes / Anita J. Merritt, Anthea Scothern, and Tanusree Bhattacharyya -- Tight junctions and cell-cell interactions / Markus Utech, Matthias Brüwer, and Asma Nusrat -- Simultaneous immunofluorescence detection of cadherin and [beta]-catenin in mouse tissue sections / Nobuko Obara --In vitro neutrophil transepithelial migration / Winston Y. Lee ... [et al.] -- The blot running assay: a method for identifying adhesion molecules mediating binding under shear conditions / Robert Sackstein and Robert Fuhlbrigge -- Cell-cell interaction in the transcellular biosynthesis of novel [omega]-3-derived lipid mediators / Nan Chiang and Charles N. Serhan -- Isolation and analysis of lipid rafts in cell-cell interactions / Aimee Landry and Ramnik Xavier.The role of junctional adhesion molecules in interactions between vascular cells / Triantafyllos Chavakis and Valeria Orlova -- Cell-cell interactions on solid matrices / Nancy A. Louis, Dionne Daniels, and Sean P. Colgan -- Cell-cell interactions in the kidney: inducible expression of mutant G protein [alpha]-subunits in madin-darby cannine kidney cells for studies of epithelial cell junction structure and function / Ernesto Sabath and Bradley M. Denker -- Nucleotide metabolism and cell-cell interactions / Holger K. Eltzschig ... [et al.] --

Cell cycle activation in neurons: the final exit of brain-morpho-dysregulation / Thomas Arendt -- Paved with good intentions: the link between cell cycle and cell death in the mammalian central nervous system / Yan Yang and Karl Herrup -- The role of presenilins in the cell cycle and apoptosis / Mervyn J. Monteiro -- Cell cycle activation and cell death in the nervous system / Zsuzsanna Nagy -- Cell cycle and chromosome segregation defects in Alzheimer's disease / Huntington Potter -- Alzheimer disease-a new beginning or a final exit? / Mark E. Obrenovich ... [et al.] -- From cell cycle activation to the inhibition of the WNT pathway: a hypothesis of how neurons die in response to B-Amyloid / Agata Copani ... [et al.].

Classes and prediction of cell-penetrating peptides -- Penetratin story: An overview -- Testing membrane interactions of CPPs -- Interactions of amphipathic CPPs with model membranes -- NMR studies of three-dimensional structure and positioning of CPPs in membrane model systems -- Measurements of the intracellular stability of CPPs -- Tools for predicting binding and insertion of CPPs into lipid bilayers -- Studies of proteoglycan involvement in CPP-mediated delivery -- Uptake kinetics of cell-penetrating peptides -- Thermodynamics of lipid interactions with cell-penetrating peptides -- Calcium and membrane repair -- Mapping of protein transduction pathways with fluorescent microscopy -- Insight into cell-entry mechanisms of CPPs by electron microscopy -- Toxicity methods for CPPs -- Comparison of CPP uptake methods -- Characterization of cellular internalization pathways for CPP-mediated oligonucleotide delivery -- Mimicry of protein function with cell-penetrating peptides -- Homeoprotein intercellular transfer, the hidden face of cell-penetrating peptides -- Pharmacology, biodistribution, and efficacy of GPCR-based pepducins in disease models -- Identification and characterization of tissue-specific protein transduction domains using peptide phage display -- Applications of cell-penetrating peptides as signal transduction modulators for the selective induction of apoptosis -- Splice redirection as a convenient assay to monitor CPP-on efficiency and mechanism -- CPP-directed oligonucleotide exon skipping in animal models of Duchenne muscular dystrophy -- PTD-DRBD siRNA delivery -- A non-covalent peptide-based strategy for siRNA delivery -- Application of pepfect peptides for the delivery of splice-correcting oligonucleotides -- Internalization of nucleoside phosphates into live cells by complex formation with different CPPs and JBS-nucleoducin -- Enhanced cellular delivery of cell-penetrating peptide-peptide nucleic acid conjugates by photochemical internalization -- Identification of homing peptides using the in vivo phage display technology -- Measuring the action of CPP-siRNA conjugates in the lung -- Intracellular delivery of nanoparticles with CPPs -- Multifunctional CPP polymer system for tumor-targeted pDNA and siRNA delivery -- Cell-penetrating penta-peptides and bax-inhibiting peptides: Protocol for their application -- Pair technology: Exon-specific rna-binding protein isolation in live cells -- Quantitation of cellular and topical uptake of luciferin-oligoarginine conjugates -- Industrial-scale manufacturing of a possible oligonucleotide cargo CPP-based drug -- Application of a fusiogenic peptide GALA for intracellular delivery -- Therapeutic applications of cell-penetrating peptides -- Nonclinical and clinical experiences with CPP-based self-assembling peptide systems in topical drug development.

Physics of Rapid Cooling and Its Implications for Cryoimmobilization of Cells /J. Dubochet --Cryopreparation Methods for Electron Microscopy of Selected Model Systems /K. McDonald --Cryopreparation Methodology for Plant Cell Biology /M. W. Hess --Correlative Light and Electron Microscopy of Early Caenorhabditis elegans Embryos in Mitosis /T. Muller-Reichert --Understanding Microtubule Organizing Centers by Comparing Mutant and Wild-Type Structures with Electron Tomography /E. T. O'Toole --Whole-Cell Investigation of Microtubule Cytoskeleton Architecture by Electron Tomography /J. L. Hoog --Electron Microscopy of Archaea /C. E. Robertson --Reconstructing Mammalian Membrane Architecture by Large Area Cellular Tomography /B. J. Marsh --Visualization of Membrane-Cytoskeletal Interactions During Plant Cytokinesis /M. S. Otegui --Electron Tomographic Methods for Studying the Chemical Synapse /C. P. Arthur --Using Electron Microscopy to Understand Functional Mechanisms of Chromosome Alignment on the Mitotic Spindle /B. F. McEwen --Electron Microscopic Analysis of the Leading Edge in Migrating Cells /T. Svitkina --Imaging Actomyosin In Situ /K. A. Taylor --Electron Tomography of Bacterial Chemotaxis Receptor Assemblies /P. Zhang --How to "Read" a Vitreous Section /J. Dubochet --Single-Particle Electron Cryomicroscopy of the Ion Channels in the Excitation-Contraction Coupling Junction /I. I. Serysheva --Electron Microscopy of Microtubule-Based Cytoskeletal Machinery /A. Hoenger --Reconstructing the Endocytotic Machinery /Y. Cheng --3D Immunolocalization with Plastic Sections /M. K. Morphew --Electron Microscopy Analysis of Viral Morphogenesis /A. Pelchen-Matthews --Electron Tomography of Immunolabeled Cryosections /M. S. Ladinsky --Visualizing Macromolecules with Fluoronanogold: From Photon Microscopy to Electron Tomography /T. Cheutin --Markers for Correlated Light and Electron Microscopy /G. E. Sosinsky --Localizing Specific Elements Bound to Macromolecules by EFTEM /R. D. Leapman --Localization of Protein Complexes by Pattern Recognition /C. Best --The Application of Energy-Filtered Electron Microscopy to Tomography of Thick, Selectively Stained Biological Samples /J. C. Bouwer --Optimization of Image Collection for Cellular Electron Microscopy /P. Mooney --Future Directions for Camera Systems in Electron Microscopy /N. Xuong --Structure Determination In Situ by Averaging of Tomograms /F. Forster --Methods for Image Segmentation in Cellular Tomography /K. Sandberg --Database Resources for Cellular Electron Microscopy /M. E. Martone.

Calcium oscillations / Ruediger Thul ... [et al.] -- Oscillations by the p53-Mdm2 feedback loop / Galit Lahav -- cAMP oscillations during aggregation of dictyostelium / William F. Loomis -- Min oscillation in bacteria / Joe Lutkenhaus -- Development on time / Isabel Palmeirim ... [et al.] -- Oscillatory expression of HES family transcription factors : insights from mathematical modelling / Hiroshi Momiji and Nicholas A.M. Monk -- Reverse engineering models of cell cycle regulation / Attila Csikøsz-Nagy, Bøla Novøk, and John J. Tyson -- Mitochondrial oscillations in physiology and pathophysiology / Miguel A. Aon, Sonia Cortassa, and Brian O'Rourke -- Respiratory oscillations in yeasts / David Lloyd -- Stochastic phase oscillator models for circadian clocks / Jacques Rougemont and Felix Naef.

Human Evolution and Physical Exercise: The Concept of Being "Born to Run" /Livio Luzi --Cell Morphology and Function: The Specificities of Muscle Cells /Anna Maestroni --The Cell Membrane of the Contractile Unit /Gianpaolo Zerbini --Gene Polymorphisms and Athletic Performance /Ileana Terruzzi --Nutrients and Whole-Body Energy Metabolism: The Impact of Physical Exercise /Stefano Benedini --Mitochondrial and Non-mitochondrial Studies of ATP Synthesis /Roberto Codella --Excessive Nutrients and Regional Energy Metabolism /Gianluca Perseghin --Muscle Biopsy To Investigate Mitochondrial Turnover /Rocco Barazzoni --Introduction to the Tracer-Based Study of Metabolism In Vivo /Andrea Caumo and Livio Luzi --Physical Activity and Inflammation /Raffaele Di Fenza and Paolo Fiorina --The HPA Axis and the Regulation of Energy Balance /Francesca Frigerio --Physical Exercise in Obesity and Anorexia Nervosa /Alberto Battezzati and Simona Bertoli --Physical Exercise and Transplantation /Valentina Delmonte, Vincenzo Lauriola, Rodolfo Alejandro and Camillo Ricordi --The Baboon as a Primate Model To Study the Physiology and Metabolic Effects of Exercise /Francesca Casiraghi, Alberto Omar Chavez, Nicholas Musi and Franco Folli.

Involvement of stress proteins in renal diseases / Razzaque, M.S., Taguchi, T. -- Stress proteins in glomerular epithelial cell injury / Bijian, K., Cybulsky, A.V. -- Response of renal medullary cells to osmotic stress / Neuhofer, W., Beck, F.-X. -- Heat shock proteins in renal cell carcinomas / Atkins, D., Lichtenfels, R., Seliger, B. -- Heat shock protein 47 and renal fibrogenesis / Razzaque, M.S., Taguchi, T. -- Cytoprotective effects of heme oxygenase in acute renal failure / Akagi, R., Takahashi, T., Sassa, S. -- Heat shock (stress response) proteins and renal ischemia/reperfusion injury / Kelly, K.J. -- Cisplatin-associated nephrotoxicity and pathological events / Taguchi, T. ... [et al.] -- Oxidant stress in renal pathophysiology / Abid, A.R., Razzaque, M.S., Taguchi, T. -- Heat shock proteins and allograft rejection / Pockley, A.G.; Muthana, M.

Korean-American pioneers in medicine -- Presence of Korean-American physicians and the birth of KAMA -- Activities of KAMA: 1974-2010 -- Photographs -- Activities of alumni associations of Korean medical schools and U.S. graduates -- Biosketches of physicians recognized in professional societies and/or community achievement -- Roster of KAMA members -- By-laws of the Korean-American Medical Association.

As people live longer and health care costs continue to rise and fewer doctors choose to specialize in geriatrics, how prepared is the United States to care for its sick and elderly? According to veteran psychologist Seymour Sarason's eloquent and compelling new book, the answer is: inadequately at best. And rarely discussed among the grim statistics is the psychosocial price paid by nursing home patients, from loneliness and isolation to depression and dependency. In "Centers for Ending", Dr. Sarason uses his firsthand experience as both practitioner and patient in senior facilities.

Part 1.Centrosomes in Reproduction --Centriole Duplication and Inheritance in Drosophila melanogaster /Tomer Avidor-Reiss, Jayachandran Gopalakrishnan, Stephanie Blachon and Andrey Polyanovsky --Sperm Centrioles and Their Dual Role in Flagellogenesis and Cell Cycle of the Zygote: Structure, Function, and Pathology /Hector E. Chemes --Centrosomal Functions and Dysfunctions in Cat Spermatozoa /Pierre Comizzoli and David E. Wildt --Nuclear-Centrosome Relationships During Fertilization, Cell Division, Embryo Development, and in Somatic Cell Nuclear Transfer Embryos /Heide Schatten and Qing-Yuan Sun --Human Centrosomal Dynamics During Gametogenesis, Fertilization, and Embryogenesis and Its Impact on Fertility: Ultrastructural Analysis /A. Henry Sathananthan --Asymmetric Centrosome Behavior in Stem Cell Divisions /Therese M. Roth, Yukiko M. Yamashita and Jun Cheng.Part 2.Cell and Molecular Biology of Centrosomes --Functional Associations Between the Golgi Apparatus and the Centrosome in Mammalian Cells /Breanne Karanikolas and Christine Sütterlin --Many Pathways to Destruction: The Role of the Centrosome in, and Its Control by Regulated Proteolysis /Harold A. Fisk --Regulation of the Centrosome Cycle by Protein Degradation /Suzanna L. Prosser and Andrew M. Fry --Molecular Links Between Centrosome Duplication and Other Cell Cycle-Associated Events /Kenji Fukasawa --Regulation of Centrosomes by Cyclin-Dependent Kinases /Rose Boutros.Part 3.Centrosome Abnormalities in Cancer --Disruption of Centrosome Duplication Control and Induction of Mitotic Instability by the High-Risk Human Papillomavirus Oncoproteins E6 and E7 /Nina Korzeniewski and Stefan Duensing --Centrosomes, DNA Damage and Aneuploidy /Chiara Saladino, Emer Bourke and Ciaran G. Morrison --Centrosome Regulation and Breast Cancer /Zeina Kais and Jeffrey D. Parvin --The Role of Centrosomes in Multiple Myeloma /Benedict Yan and Wee-Joo Chng --Centrosomal Amplification and Related Abnormalities Induced by Nucleoside Analogs /Ofelia A. Olivero --Mechanisms and Consequences of Centrosome Clustering in Cancer Cells /Alwin Krämer, Simon Anderhub and Bettina Maier.Part 4.Centrosomes in Other Systems --Re-evaluation of the Neuronal Centrosome as a Generator of Microtubules for Axons and Dendrites /Peter W. Baas and Aditi Falnikar --Centrosomes and Cell Division in Apicomplexa /Leandro Lemgruber, Marek Cyrklaff and Freddy Frischknecht --The Centrosome Life Story in Xenopuslaevis /Jacek Z. Kubiak and Claude Prigent --Role of the MTOC in T Cell Effector Functions /Martin Poenie, Laura Christian, Sarah Tan and Yuri Sykulev --Thoughts on Progress in the Centrosome Field /Jeffrey L. Salisbury.

Early studies on centrioles and centrosomes -- Tubulin superfamily -- Microtubule nucleation -- The budding yeast spindle pole body: a centrosome analog -- Dissection of basal body and centriole function in the unicellular green alga chlamydomonas reinhardtii -- The centrosome in evolution -- A proteomic approach to the inventory of the human centrosome -- The role of the centrosome in cell cycle progression -- Centrosome duplication and its regulation in the higher animal cell -- A synergy of technologies: using green fluorescent protein tagging and laser microsurgery to study centrosome function and duplication in vertebrates -- Centrosome regulation in response to environmental and genotoxic stress -- The C. elegans centrosome during early embryonic development -- Centrosomes in a developing organism: lessons from drosophila -- Centrosome inheritance during human fertilization and "therapeutic" cloning: reproductive and developmental diseases and disorders caused by centrosome dysfunction -- Microtubule organizing centers in polarized epithelial cells -- Centrosome anomalies in cancer: from early observations to animal models -- Radiation therapy and centrosome anomalies in pancreatic cancer -- Human papillomavirus infection and centrosome anomalies in cervical cancer -- Manipulation of centrosomes and the microtubule cytoskeleton during infection by intracellular pathogens -- Basal bodies and microtubule organization in pathogenic protozoa.

The First Fifty Years of Mendelism -- 1. The Introduction of Mendelism into Human Genetics / Milo Keynes -- 2. Galton's Theory of Ancestral Inheritance / Michael Bulmer -- 3. The Reception of Mendelism by the Biometricians and the Early Mendelians (1899-1909) / Eileen Magnello -- 4. Mendelism and Man 1918-1939 / A.W.F. Edwards -- 5. William Bateson, Archibald Garrod and the Nature of the

Chapter 1 Ceramic Membranes and Membrane Processes, p. 1-20 -- Chapter 2. Preparation of Ceramic Membranes, p. 21-57 -- Chapter 3. Characterization of Ceramic Membranes, p. 59-95 -- Chapter 4. Transport and Separation of Gases in Porous Ceramic Membranes, p. 97-134 -- Chapter 5. Ceramic Hollow Fibre Membrane Contactors for Treatment of Gases/Vapours, p. 135-168 -- Chapter 6 Mixed Conducting Ceramic Membranes for Oxygen Separation, p. 169-215 -- Chapter 7. Mixed Conducting Ceramic Membranes for Hydrogen Permeation, p. 217-243 -- Chapter 8. Ceramic Membrane Reactors, p. 245-298.

Cerebral monitoring in the operating room and the intensive care unit: an introductory for the clinician and a guide for the novice wanting to open a window to the brain. Part I: the electroencephalogram / Enno Freye and Joseph V. Levy -- Part II: sensory-evoked potentials (SSEP, AEP, VEP) / Enno Freye -- Part III: spinal cord evoked potentials / Enno Freye.

Cesarean hysterectomy: an analysis of one thousand consecutive operations -- Additional statistics for elective cesarean hysterectomy -- Additional statistics for emergency cesarean hysterectomy -- Miscellaneous statistics -- Urinary tract injuries at time of cesarean hysterectomy -- Cesarean hysterectomy and cancer -- Maternal deaths -- Early history of cesarean hysterectomy.

pt. 1. The why, what, and when of cesarean section -- Why are cesarean sections performed? -- A brief history of cesarean section -- What happens in cesarean section and who performs the surgery? -- When is a cesarean section an emergency? -- When is a cesarean section not an emergency? -- Considering the risks of cesarean section -- pt. 2. What's next? After a cesarean section -- Going home: you and your family -- Postpartum depression -- Contraception -- Vaginal birth after cesarean section.

The Anthrax Capsule: Role in Pathogenesis and Target for Vaccines and Therapeutics / Arthur M. Friedlander -- Proteomic Studies of Bacillus anthracis Reveal In Vitro CO2-Modulation and Expression During Infection of Extracellular Proteases / Theodor Chitlaru, Orit Gat, Galia Zaide, Haim Grosfeld and Izhak Inbar, et al. -- Dynamics of Bacillus anthracis Infection and Control Mechanisms / Pierre L. Goossens, Ian J. Glomski, Lhousseine Touqui and Michèle Mock -- Survival and Trafficking of Yersinia pestis in Non-acidified Phagosomes in Murine Macrophages / James B. Bliska -- The Inverse Relationship Between Cytotoxicity of Y. pestis and Its Virulence / Emanuelle Mamroud, Avital Tidhar, Yinon Levy, Erez Bar-Haim and Gideon Halperin, et al. -- The NlpD Lipoprotein of Yersinia pestis is Essential for Cell Separation and Virulence / Avital Tidhar, Yehuda Flashner, Sara Cohen, Yinon Levy and Ayelet Zauberman, et al. -- Dissection of the Functions of the IglC Protein of Francisella tularensis / Jeanette E. Bröms, Moa Lavander and Anders Sjöstedt -- Yersinia pestis Lipopolysaccharide in Host-Pathogen Interactions / Andrey P. Anisimov, Svetlana V. Dentovskaya, Anna N. Kondakova, Buko Lindner and Rima Z. Shaikhutdinova, et al. -- The Interactions Between Pathogens and Dendritic Cells: From Paralysis of Cells to Their Recruitment for Bacterial Colonization / Baruch Velan, Erez Bar-Haim, Gal Markel, Hila Cohen and Ayelet Zauberman, et al. -- Comparative Approaches to Identify Host Factors Specifically Targeted by Yersinia pestis During the Infectious Process / Françoise Guinet, Patrick Avé, Louis Jones, Michel Huerre and Elisabeth Carniel -- Poxvirus Entry into Host Cells / Bernard Moss, Zain Bengali, Himani Bisht, Jason P. Laliberte and P.S. Satheskumar -- Role of A33R Amino-Acid 118L in the Interactions of Vaccinia Virus with the Host / Nir Paran, Shlomo Lustig, Anat Zvi, Tomer Israely and Sharon Melamed, et al. -- Inhibitors of Innate Immunity from Vaccinia Virus / Geoffrey L. Smith -- Brucella Species Synchronize Their Life Cycle to the Gestation Cycle of Their Ruminant Hosts / Svetlana Bardenstein and Menachem Banai -- MMP-9 as a Marker for Vaccinia Virus Related Encephalitis / Tomer Israely, Sharon Melamed, Noam Erez, Boaz Politi and Udy Olshevsky, et al. -- Epidemic Cowpox Virus Infections in Germany / Andreas Kurth and Andreas Nitsche -- The Two Partner Secretion Transporters of Yersinia pestis: Cloning, Immunogenicity and In Vivo Expression Following Airway Infection / Yinon Levy, Anat Zvi, Haim Grosfeld, Avital Tidhar and David Gur, et al. --Genetic Detection of Vesicle Forming Pathogens by Arrayed Primer Extension (APEX) / Adi Beth-Din, Ofir Israeli, Ohad Shifman, Dana Stein and Einat Ben-Arie, et al. -- Subtyping Biothreat Bacterial Pathogens / Paul Keim and Talima Pearson -- A Rapid Method for Bacillus anthracis Genotyping / Haim Levy, Morly Fisher, Naomi Ariel, Shay Weiss and Anat Zvi, et al. -- Tularemia - A Disease with an Uncertain Impact on Public Health / Roland Grunow, Daniela Jacob, Andrea Kühn and Herbert Nattermann -- Consequences of Antibiotic Treatment of Francisella tularensis Airways Infections / Erez Bar-Haim, Hila Cohen, Raphael Ber, Ofer Cohen and Avigdor Shafferman -- Novel Live Vaccine Candidates Against Airborne Francisella tularensis / Wayne Conlan and Anders Sjöstedt -- Effect of Disruption of mglA on the Virulence and Immunogenicity of the Francisella tularensis Live Vaccine Strain (LVS) / Ofer Cohen, Galia Zaide, Erez Bar-Haim, Itai Mendelson and Orit Gat, et al. -- Data Mining, Bioinformatic and Immunoinformatic Analyses of Francisella tularensis Schu S4 Genome in Search for Novel Vaccine Candidates / Anat Zvi, Naomi Ariel and Avigdor Shafferman -- Modified Vaccinia Virus Ankara (MVA) based Vaccines - Immunostimulatory and Protective Capacity / Michael H. Lehmann, Melanie Kremer, Yasemin Suezer and Gerd Sutter -- Therapeutic Potential of Vaccinia Hyper Immune Sera in Mouse Models of Lethal Orthopoxviruses Infection / Sharon Melamed, Nir Paran, Tomer Israely, Noam Erez and Shaul Reuveny, et al. -- A Live Plaque Vaccine Candidate with Improved Safety and Immunogenecity / V.A. Feodorova, L.N. Pan'kina, E.P. Savostina, O.S. Kuznetsov and N.P. Konnov, et al. -- Protection Against Plague Afforded by Treatment with Polyclonal αLcrV and αF1 Antibodies / Yinon Levy, Yehuda Flashner, Ayelet Zauberman, Avital Tidhar and Moshe Aftalion, et al. -- Combination of Anthrax-Toxin Neutralizing Antibodies: Analysis of Synergism/Antagonism Effect / Ohad Mazor, Einat Ben-Arie, Adva Mechaly, Ronit Rosenfeld and Hadar Marcus, et al. -- The Efficacy of Antibiotic Treatment to Cure Guinea Pigs Intranasally Infected with Bacillus anthracis Spores / Zeev Altboum, Haim Levy, Shay Weiss, Avi Pass and Nili Rothschild, et al. -- Reverse Vaccinology in Bacillus anthracis / Avigdor Shafferman, Orit Gat, Naomi Ariel, Theodor Chitlaru and Haim Grosfeld, et al.

Rhinitis -- Chronic rhinosinusitis -- Allergic diseases of the eye -- Urticaria and angioedema -- Allergic contact dermatitis -- Hypersensitivity pneumonitis -- Atopic dermatitis -- Food allergy -- Drug allergy -- Anaphylaxis -- Eosinophilia and eosinophilic disorder -- Occupational asthma -- Asthma conundrums -- Mastocytosis -- Allergic bronchopulmonary aspergillosis -- HIV/AIDS and complications -- Disorders of immune regulation -- Autoimmune diseases -- Immune-mediated rheumatic diseases -- Immunodeficiency.

Section A. The basics. -- 1. Taking a history -- 2. An approach to the physical examination -- 3. Devising a different diagnosis -- 4. Ordering basic investigations -- 5. Medical records -- 6. Presenting cases -- Section B. Individual systems. -- 7. The cardiovascular system -- 8. The respiratory system -- 9. The gastrointestinal system -- 10. The renal system -- 11. The genitourinary system -- 12. The nervous system -- 13. Psychiatric assessment -- 14. The musculoskeletal system -- 15. The endocrine system -- 16. The breast -- 17. The haematological system -- 18. Skin, nails and hair -- 19. The eye -- 20. Ear, nose and throat -- 21. Infectious and tropical diseases -- Section C. Special situations. -- 22. Assessment of the newborn, infants and children -- 23. The acutely ill patient -- 24. The patient with impaired consciousness -- 25. The older patient -- 26. Death and the dying patient.

Emerging disease in the third epidemiological transition -- Life history perspectives on human disease -- The Evolution, transmission and geographic spread of infectious diseases in human populations: questions and models -- Genetic epidemiology of parasitic diseases -- Urban pollution, disease and the health of children -- Protecting pregnant women from malaria -- Interdisciplinary research on Schistosoma japonicum -- Unravelling gene-environment interactions in type 2 diabetes -- Investigating the "hidden" epidemic: sexual behaviour and representation of HIV/AIDS amongst business people and medical personnel in five Central and Eastern European nations -- The Evolution of disease and the devolution of health care for American Indians -- The Public's health: the changing role of public health -- Human behaviour and the changing pattern of disease.

Part I. Large Intestine -- Concepts in Surgery of the Large Intestine / Danny M. Takanishi and Fabrizio Michelassi -- Right Colectomy for Cancer -- Laparoscopic Right Hemicolectomy / Steven D. Wexner and Susan M. Cera -- Left Colectomy for Cancer -- Laparoscopic Left Hemicolectomy / Steven D. Wexner -- Low Anterior Resection for Rectal Cancer -- Abdominoperineal Resection for Rectal Cancer -- Laparoscopic Abdominoperineal Resection and Total Proctocolectomy with End Ileostomy / Steven D. Wexner and Giovanna M. DaSilva -- Subtotal Colectomy with Ileoproctostomy or Ileostomy and Sigmoid Mucous Fistula -- Ileoanal Anastomosis with Ileal Reservoir Following Total Colectomy and Mucosal Proctectomy -- Abdominoperineal Protectomy for Benign Disease -- End-Ileostomy -- Loop Ileostomy -- Cecostomy -- Surgical Legacy Technique -- Transverse Colostomy -- Closure of Temporary Colostomy -- Laparoscopic Stoma Construction and Closure / Dan Enger Ruiz and Steven D. Wexner -- Operations for Colonic Diverticulitis (Including Lower Gastrointestinal Bleeding) -- Ripstein Operation for Rectal Prolapse -- Part II. Anus, Rectum, and Pilonidal Region -- Concepts in Surgery of the Anus, Rectum, and Pilonidal Region / Amanda M. Metcalf -- Rubber Band Ligation of Internal Hemorrhoids -- Hemorrhoidectomy -- Anorectal Fistula and Pelvirectal Abscess -- Lateral Internal Sphincterotomy for Chronic Anal Fissure -- Anoplasty for Anal Stenosis -- Thiersch Operation for Rectal Prolapse Surgical Legacy Technique -- Operations for Pilonidal Disease.

Reveals the surprising power of the ordinary checklist now being used in medicine, aviation, the armed services, homeland security, investment banking, skyscraper construction, and businesses of all kinds.

v. 1. Reviews and model systems -- v. 2. Activation and regulation protocols.

v. 1. General aspects -- v. 2. Major cheese groups.

What is chemical genomics? /Paul R. Caron --In silico chemical genomics /György M. Keserʺu, Zoltán Kovári --Optimizing the chemical genomics process /William Janzen ... [et al.] --Microchip-based high-throughput screening in chemical genomics /Julia Khandurina, Tong Zhu, András Guttman --Utilizing small molecules in chemical genomics : toward HT approaches /György Dormán, Ferenc Darvas --Multifunctional photoprobes for rapid protein identification /Yutaka Sadakane, Yasumaru Hatanaka --Defining the lipidome : a new target for therapeutics /Li Feng ... [et al.] --Pharmacogenetic aspects of dopaminergic neurotransmission-related gene polymorphisms /Zsofia Nemoda ... [et al.] --Approximate string-matching algorithm for DNA patenting evaluation in the pharmaceutical industry /G. Dufresne, L. Takacs, M. Duval.

Historical overview of chemical library design / Roland E. Dolle -- Chemoinformatics and library design / Joe Zongxiang Zhou -- Molecular library design using multi-objective optimization methods / Christos A. Nicolaou and Christos C. Kannas -- A scalable approach to combinatorial library design / Puneet Sharma, Srinivasa Salapaka, and Carolyn Beck -- Application of Free-Wilson selectivity analysis for combinatorial library design / Simone Sciabola ... [et al.] -- Application of QSAR and shape pharmacophore modeling approaches for targeted chemical library design / Jerry O. Ebalunode, Weifan Zheng, and Alexander Tropsha -- Combinatorial library design from reagent pharmacophore fingerprints / Hongming Chen, Ola Engkvist, and Niklas Blomberg -- Docking methods for structure-based library design / Claudio N. Cavasotto and Sharangdhar S. Phatak -- Structure-based library design in efficient discovery of novel inhibitors / Shunqi Yan and Robert Selliah -- Structure-based and property-compliant library design of 11[beta]-HSD1 adamantyl amide inhibitors / Genevieve D. Paderes ... [et al.] -- Design of screening collections for successful fragment-based lead discovery / James Na and Qiyue Hu -- Fragment-based drug design / Eric Feyfant ... [et al.] -- LEAP into the Pfizer Global Virtual Library (PGVL) space : creation of readily synthesizable design ideas automatically / Qiyue Hu ... [et al.] -- The design, annotation, and application of a kinase-targeted library / Hualin Xi and Elizabeth A. Lunney -- PGVL hub : an integrated desktop tool for medicinal chemists to streamline design and synthesis of chemical libraries and singleton compounds / Zhengwei Peng ... [et al.] -- Design of targeted libraries against the human Chk1 kinase using PGVL hub / Xengwei Peng and Qiyue Hu -- GLARE : a tool for product-oriented design of combinatorial libraries / Jean-François Truchon -- CLEVER : a general design tool for combinatorial libraries / Tze Hau Lam ... [et al.].

pt. 1. Regulation and quality control of chemical migration into food -- pt. 2. Assessing the risks and improving the safety of food contact materials -- pt. 3. Chemical migration from particular food contact materials.

Brief history and use of chemical warfare agents in warfare and terrorism / Harry Salem, Andrew L. Ternay, Jr., and Jeffery K. Smart -- The chemistry of chemical warfare agents / Peter Kikilo, Vitaly Fedorenko, and Andrew L. Ternay, Jr. -- Chemical warfare agent threat to drinking water / Harry Salem ... [et al.] -- Health effects of low-level exposure to nerve agents / John H. McDonough and James A. Romano, Jr. -- Toxicokinetics of nerve agents / Marcel J. van der Schans, Hendrik P. Benschop, and Christopher E. Whalley -- Application of genomic, proteomic, and metabolomic technologies to the development of countermeasures against chemical warfare agents / Jennifer Sekowski and James Dillman -- Novel approaches to medical protection against chemical warfare nerve agents / Ashima Saxena ... [et al.] -- Nerve agent bioscavengers : progress in development of a new mode of protection against organophosphorus exposure / David E. Lenz ... [et al.] -- Butyrylcholinesterase and its synthetic C-terminal peptide confer in-vitro suppression of amyloid fibrils formation / Erez Podoly ... [et al.] -- A novel medical countermeasure for organophosphorus intoxication : connection to Alzheimer's disease and dementia / Edna F. R. Pereira ... [et al.] -- Inhalation toxicology of nerve agents / Paul A. Dabisch ...[et al.] -- Vesicants and oxidative stress / Milton G. Smith ...[et al.] -- Health effects of exposure to vesicant agents / Charles G. Hurst and William J. Smith -- Cyanides : toxicology, clinical presentation, and medical management / Bryan Ballantyne and Harry Salem -- Chemicals used for riot control and personal protection / Harry Salem, Bryan Ballantyne, and Sydney Katz -- Mechanism of action of botulinum neurotoxin and overview of medical countermeasure development for intoxication / Michael Adler ... [et al.] -- Ricin and related toxins : review and perspective / Charles B. Millard and Ross D. LeClaire -- Screening smokes : applications, toxicology, clinical considerations and medical management / Bryan Ballantyne and Harry Salem -- Clinical detection of exposure to chemical warfare agents / Benedict R. Capacio ... [et al.] -- Personal protective equipment (ppe) : practical and theoretical considerations / Michael R. Jones -- Chemical warfare agent decontamination from skin / Brian J. Lukey ... [et al.] -- Chemical warfare, chemical terrorism, and traumatic stress responses : an assessment of psychological impact / James A. Romano, Jr. ... [et al.] -- Emergency response to a chemical warfare agent incident : domestic preparedness, first response, and public health considerations / David H. Moore and Barbara Saunders-Price -- Emergency medical response to a chemical terrorist attack / Stephen A. Pulley and Michael R. Jones.

Abstraction -- Accident -- Accuracy -- Acid -- Adsorption -- Aesthetic -- Affinity -- Age -- Air -- Alchemy -- Ambition -- Analogy -- Analysis -- Analyst -- Answer -- Apparatus -- Approximate -- Atom -- Atomic weight -- Authority -- Average -- Balance -- Beauty -- Biochemistry -- Book -- Bubble -- Calculation -- Candle -- Cause and effect -- Central limit theorem -- Chance -- Chaos -- Chemical -- Chemical affinities -- Chemical engineer -- Chemical limericks -- Chemical mnemonics -- Chemist -- Chemistry -- Chemistry and life -- Chemistry and medicine -- Chemistry songs -- Classroom emanations -- Commandments -- Common sense -- Communication -- Compound -- Concept -- Confusion -- Cosmochemistry -- Creativity -- Criticism -- Crystal -- Crystallography -- Curiosity -- Data -- Definition -- Demonstration -- Difference -- Discovery -- Disorder -- Distill -- Electron -- Element -- Energy -- Energy state -- Enzyme -- Error -- Ethics -- Experience -- Experiment -- Experimenter -- Explain -- Fact -- Faith -- Fermentation -- Filter -- Fire -- Fluorochemistry -- Force -- Forecast -- Formula -- Fractal -- Gas -- Generality -- Genius -- Geochemistry -- Glassware -- God -- Graph -- Guess --Heat -- History -- Hypothesis -- Idea -- Ignorance -- Imagination -- Impossible -- Improbable -- Independence -- Inference -- Information -- Inorganic -- Instrument -- Ion -- Knowledge -- Laboratory -- Language -- Law -- Learn -- Life -- Literature -- Little Willie -- Magic -- Mathematics -- Matter -- Measurement -- Mechanics -- Metal -- Metaphor -- Metaphysics -- Method -- Microscope -- Model -- Molecule -- Motion -- Mystery -- Naivete -- Name -- Nature -- Nomenclature -- Notation -- Null hypothesis -- Numbers -- Observation -- Occam's razor -- Opinion -- Order -- Organic -- Outlier -- Paradox -- Periodic law -- Philosophy -- Physical science -- Plagerism -- Pollution -- Postulate -- Prayer -- Precision -- Prediction -- Probability -- Problem -- Progress -- Proposition -- Publication -- Purity -- Purpose -- Question -- Radical -- Random -- Reaction -- Reason -- Research -- Results -- Rust -- Salt -- Science -- Scientific -- Scientist -- Silver trees -- Simplicity -- Solid -- Soluble -- Solution -- Speculation -- Statistical -- Statistician -- Statistics -- Symbol -- Symmetry -- Synthesis -- Teaching -- Terminology -- Theorist -- Theory -- Thermodynamics -- Thought -- Trial and error -- Truth -- Uncertainty -- Understand -- Unexpected -- Unknown -- Vacuum -- Vision -- Volume -- Water -- Wisdom -- Word -- Work -- Writing -- X-rays.

Inflammatory mechanisms in Alzheimer's disease and other neurodegenerative disorders / Joseph Rogers ... [et al.] -- Treatment development strategies for Alzheimer's disease / Ernst Wulfert -- Lipoprotein-associated phospholipase A as a new prognostic factor for coronary artery disease / Alexandros D. Tselepis -- New molecular targets for the prevention and treatment of gastrointestinal ulcers and inflammation / Sandor Szabo ... [et al.] -- Stress activates corticotropin releasing : factor signaling pathways : implication in functional bowel disorders / Yvette Tache -- Design, synthesis, and pharmacological evaluation of high-affinity and selectivity sigma-1 and sigma-2 receptor ligands / Jacques H. Poupaert -- Synthesis of biologically active taxoids / K.C. Nicolaou and R.K. Guy -- From the molecular pharmacology to the medicinal chemistry of cannabinoids / Didier M. Lambert -- An appraisal of fomocaines : current situation and outlook / Herbert Oelschlager and Andreas Seeling -- Ligands for the GABA recognition site at the GABAA receptor : structure-activity studies / Bente Frlund ... [et al.] -- Strategies for development of new lead structures for inhibition of acetylcholinesterase / Petra Kapkova ... [et al.] -- Discovery of potent and selective inhibitors of human aldosterone synthase (CYP11B2) : a new target for the treatment of congestive heart failure and myocardial fibrosis--a review / R.W. Hartmann ... [et al.] --Thiocarboxanilides : a new class of nonnucleoside reverse transcriptase inhibitors (NNRTIs) with great potential for the treatment of human immunodeficiency virus type 1 (HIV-1) infections / E. De Clercq, A. Karlsson, and J. Balzarini -- Histamine H-receptor agonists and antagonists : chemical, pharmacological, and clinical aspects / Holger Stark and Walter Schunack -- Anti-inflammatory actions of flavonoids and structural requirements for new design / Theoharis C. Theoharides -- Molecular mechanisms of HO-induced DNA damage : the action of desferrioxamine / M. Tenopoulou, P.-T Doulias, and D. Galaris -- LNA (locked nucleic acid) and functionalized LNA : towards efficient gene targeting / Jesper Wengel -- The effect of diet on drug metabolism / K.J. Netter -- Cytochromes P450 in the metabolism and bioactivation of chemicals / Costas Ioannides -- In vitro methods to measure drug metabolism and drug interactions in drug discovery and development / O. Pelkonen ... [et al.] -- How to probe the sites of action of drug molecules / A. Makriyannis and F. Bitter -- Physicochemical profiling in early drug discovery : new challenges at the age of high-throughput screen and combinatorial chemistry / Bernard Faller -- Drug membrane interaction and its importance for drug efficacy / J.K. Seydel ... [et al.] -- The fight against AIDS : new avenues for inhibiting reverse transcriptase (RT), and old target / Maurizio Botta ... [et al.].

Introduction to cancer -- Antimetabolites -- DNA-interactive agents -- Antitubulin agents -- Cell signaling inhibitors -- Hormonal therapies -- Tumour targeting strategies -- Biologicals -- The future -- Personalized medicine (oncogenomics) -- Adjunct therapies.

1. The evolution of earth-the geochemical partner of the global ecosystem (5 billion years of history) -- 2. Basic chemistry of the ecosystem -- 3. Energy, order and disorder, and organised systems -- 4. Outline of biological chemical principles : components, pathways and controls -- 5. First steps in evolution of prokaryotes : anaerobic chemotypes four to three billion years ago -- 6. The evolution of protoaerobic and aerobic prokaryote chemotypes (three to two billion years ago) -- 7. Unicellular eukaryotes chemotypes (about one and a half billion years ago?) -- 8. Multi-cellular eukaryote chemotypes (from one billion years ago) -- 9. The evolution of chemotypes with nerves and a brain (0.5 billion years ago to today) -- 10. Evolution due to mankind : a completely novel chemotype (less than one hundred thousand years ago) -- 11. Conclusion : the inevitable factors in evolution

v. 1. Nanomaterials : an introduction / C.N.R. Rao, A. Müller, A.K. Cheetham -- Strategies for the scalable synthesis of quantum dots and related nanodimensional materials / Paul O'Brien, N. Pickett -- Moving nanoparticles around : phase-transfer processes in nanomaterials synthesis / M. Sastry -- Mesoscopic assembly and other properties of metal and semiconductor nanocrystals / G.U. Kulkarni, P.J. Thomas, C.N.R. Rao -- Oxide nanoparticles / R. Seshadri -- Sonochemistry and other novel methods developed for the synthesis of nanoparticles / Y. Mastai, A. Gedanken -- Solvothermal synthesis of non-oxide nanomaterials / Y.T. Qian, Y.L. Gu, J. Lu -- Nanotubes and nanowires / A. Govindaraj, C.N.R. Rao -- Synthesis, assembly and reactivity of metallic nanorods / C.J. Murphy ... [et al.] -- Oxide-assisted growth of silicon and related nanowires : growth mechanism, structure and properties / S.T. Lee, R.Q. Zhang, Y. Lifshitz -- v. 2. Electronic structure and spectroscopy of semiconductor nanocrystals / S. Sapra, D.D. Sarma -- Core-shell semiconductor nanocrystals for biological labeling / R.E. Bailey, S. Nie -- Large semiconductor molecules / J.F. Corrigan, M.W. DeGroot -- Oxomolybdates : from structures to functions in a new era of nanochemistry / A. Müller, S. Roy -- Nanostructured polymers / S. Ramakrishnan -- Recent developments in the chemistry and chemical applications of porous silicon / J.M. Schmeltzer, J.M. Buriak -- Nanocatalysis / S. Abbet, U. Heiz -- Nanoporous materials / A.K. Cheetham, P.M. Forster -- Photochemistry and electrochemistry of nanoassemblies / P.V. Kamat -- Electrochemistry with nanoparticles / S. Devarajan, S. Sampath -- Nanolithography and nanomanipulation / A.K. Raychaudhuri.

Chapter 1. Fundamentals of Peptide Synthesis -- Chapter 2. Methods for the Formation of Peptide Bonds -- Chapter 3. Protectors and Methods of Deprotection -- Chapter 4. Chirality in Peptide Synthesis -- Chapter 5. Solid-Phase Synthesis -- Chapter 6. Reactivity, Protection and Side Reactions -- Chapter 7. Ventilation of Activated Forms and Coupling Methods -- Chapter 8. Miscellaneous.

Short introduction and history / Robert B. Raffa -- Patient's perspective / Robert B. Raffa and Kathy Martin -- Oncology nurse's perspective / Jamie S. Myers -- Oncology pharmacist's perspective / Rachel Clark-Vetri -- The impact of chemo brain on the patient with a high grade glioma / Michele R. Lucas -- Oncology pharmacist's perspective / Rachel Clark-Vetri -- The impact of chemo brain on the patient with a high grade glioma / Michele R. Lucas -- Neurocognitive effects of childhood cancer treatment / Jennifer Costa -- The economic burden / Albert I. Wertheimer -- Designing conceptual model-based research in chemotherapy-related changes in cognitive function / Lisa M. Hess -- Neuropsychologic testing for chemotherapy-related cognitive impairment / Jamie S. Myers -- Imaging as a means of studying chemotherapy-related cognitive impairment / Robert B. Raffa -- Chemotherapy associated central nervous system damage / Jørg Dietrich -- Is systemic anti-cancer therapy neurotoxic? Does chemo brain exist? And should we rename it? / Sophie Taillibert -- Evaluation of multiple neurotoxic outcomes in cancer chemotherapy / Bernard Weiss -- Chemotherapy-related visual system toxicity / Robert B. Raffa -- The possible role of cytokines in chemotherapy-induced cognitive deficits / Jamie S. Myers -- Pharmacokinetics of anti-cancer drugs used in breast cancer chemotherapy / Swati Nagar -- Combination analysis / Ronald J. Tallarida -- Animal models / Ellen A. Walker -- Chemo brain (chemo fog) as a potential side effect of doxorubicin administration : role of cytokine-induced, oxidative/nitrosative stress in cognitive dysfunction / Christopher D. Aluise ... [et al.] -- Effects of 5-FU / Peter M. Wigmore ... [et al.] -- Future directions / Robert B. Raffa and Ronald J. Tallarida.

ch. 1. Introduction / Johann Gasteiger -- ch. 2. Representation of chemical compounds / Thomas Engel -- ch. 3. Representation of chemical reactions / Johann Gasteiger -- ch. 4. The Data / Giorgi Lekishvili -- ch. 5. Databases and data sources in chemistry / Thomas Engel -- ch. 6. Searching chemical structures / Nikolay Kochev, Valentin Monev and Ivan Bangov -- ch. 7. Calculation of physical and chemical data -- ch. 8. Calculation of structure descriptors / Lothar Terfloth -- ch. 9. Methods for data analysis / U. Burkard -- ch. 10. Applications / Thomas Kleinöder, Aixia Yan, Simon Spycher, Markus Hemmer, João Aires de Sousa and Lothar Terfloth -- ch. 11 Future directions / Johann Gasteiger.

Some Trends in Chem(o)informatics / Wendy A. Warr -- Molecular Similarity Measures / Gerald M. Maggiora and Veerabahu Shanmugasundaram -- The Ups and Downs of Structure-Activity Landscapes / Rajarshi Guha -- Computational Analysis of Activity and Selectivity Cliffs / Lisa Peltason and Jurgen Bajorath -- Similarity Searching Using 2D Structural Fingerprints / Peter Willett -- Predicting the Performance of Fingerprint Similarity Searching / Martin Vogt and Jurgen Bajorath -- Bayesian Methods in Virtual Screening and Chemical Biology / Andreas Bender -- Reduced Graphs and Their Applications in Chemoinformatics / Kristian Birchall and Valerie J. Gillet -- Fragment Descriptors in Structure-Property Modeling and Virtual Screening / Alexandre Varnek -- The Scaffold Tree: An Efficient Navigation in the Scaffold Universe / Peter Ertl, Ansgar Schuffenhauer, and Steffen Renner -- Pharmacophore-Based Virtual Screening / Dragos Horvath -- De Novo Drug Design / Markus Hartenfeller and Gisbert Schneider -- Classification of Chemical Reactions and Chemoinformatics Processing of Enzymatic Transformations / Diogo A.R.S. Latino and Joao Aires-de-Sousa -- Informatics Approach to the Rational Design of siRNA Libraries / Jerry O. Ebalunode, Charles Jagun, and Weifan Zheng -- Beyond Rhodopsin: G Protein-Coupled Receptor Structure and Modeling Incorporating the b2-adrenergic and Adenosine A2A Crystal Structures / Andrew J. Tebben and Dora M. Schnur -- Methods for Combinatorial and Parallel Library Design / Dora M. Schnur, Brett R. Beno, Andrew J. Tebben, and Cullen Cavallaro -- The Interweaving of Cheminformatics and HTS / Anne Kummel and Christian N. Parker -- Computational Systems Chemical Biology / Tudor I. Oprea, Elebeoba E. May, Andrei Leitao, and Alexander Tropsha -- Ligand-Based Approaches to In Silico Pharmacology / David Vidal, Ricard Garcia-Serna, and Jordi Mestres -- Molecular Test Systems for Computational Selectivity Studies and Systematic Analysis of Compound Selectivity Profiles / Dagmar Stumpfe, Eugen Lounkine, and Jurgen Bajorath -- Application of Support Vector Machine-Based Ranking Strategies to Search for Target-Selective Compounds / Anne Mai Wassermann, Hanna Geppert, and Jurgen Bajorath -- What Do We Know?: Simple Statistical Techniques that Help / Anthony Nicholls.

v. 1. Immunology of chemokines / Bernhard Moser, Gordon L. Letts [sic], Kuldeep Neote (editors) -- v. 2. Pathophysiology of chemokines / Kuldeep Neote, Gordon L. Letts [sic], Bernard Moser (editors).

Part I. Introduction.-- Chemokine system in experimental and clinical hematology / Oystein Bruserud, Astrid Olsnes Kittang.-- Part II. Experimental hematology.-- Chemokine decoy receptors: strucuture-function and biological properties / Raffaella Bonecchi, Benedetta Savino, Elena M. Borroni, Alberto Mantovani, Massimo Locati.-- Role of chemokines in the biology of natural killer cells / Azzram A. Maghazachi.-- Chemokines in angiogenesis / Anna Dimbert.-- Part III. Immunobiology of allogeneic stem cell transplantation.-- Genetic polymorphisms in the cytokine and chemokine systems: their possible importance in allogeneic stem cell transplantation / Jeurgen Loeffler, Michael Ok, Oliver C. Morton, Markus Mezger, Hermann Einsele.-- Chemokine system: a possible therapeutic target in acute graft versus host disease / Nicolai A. Kittan, Gerhard C. Hildebrandt.-- Homing in on acute graft vs. host disease: tissue-specific T regulatory and Th17 cells / Brian G. Engelhardt, James E. Crowe Jr.-- Part IV: Clinical hematology.-- Chemokine network in acute myelogenous leukemia: molecular mechanisms involved in leukemogenesis and therapeutic implications / Astrid Olsnes Kittang, Kimberley Hatfield, Kristoffer Sand, Hakon Reikvam, Oystein Bruserud.-- CXCR4 in clinical hematology / Gary Calandra, Gary Bridger, Simon Fricker.-- Immunobiology of herparin-induced thrombocytopenia / Per Morten Sandset.

Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system / T.E. Lane, J.L. Hardison, and K.B. Walsh -- Cytokine and chemokine networks : pathways to antiviral defense / T.P. Salazar-Mather and K.L. Hokeness -- Herpes simplex virus and the chemokines that mediate the inflammation / D.J.J. Carr and L. Tomanek -- Influence of proinflammatory cytokines and chemokines on the neuropathogenesis of oncornavirus and immunosuppressive lentivirus infections / K.E. Peterson and B. Chesebro -- HIV-1 coreceptors and their inhibitors / N. Ray and R.W. Doms -- A viral conspiracy : hijacking the chemokine system through virally encoded pirated chemokine receptors / H.F. Vischer, C. Vink, and M.J. Smit.

Chemokines and receptors in disease -- Chemokine related proteins from pathogens -- Atypical and novel chemoattractants and receptors -- Chemokine signaling.

v. 1. In vitro assays -- v. 2 In vitro models, imaging, and molecular regulators.

Scientific basis of cancer chemotherapy -- Norton-simon hypothesis -- Drug resistance -- Principles of chemotherapy -- Clinical trials -- Hematopoietic growth factors -- Biologic response modifiers: principles of biotherapy -- Intraventricular and intrathecal therapy -- Intraperitoneal chemotherapy -- Continuous intravenous infusion chemotherapy -- Intraarterial chemotherapy -- Isolated regional therapy -- Hematopoietic stem cell transplantation -- Oral toxicity -- Dermatologic toxicity -- Extravasation -- Hypersensitivity reactions -- Ocular side effects of chemotherapy -- Cardiotoxicity of cancer therapy -- Pulmonary toxicity of antineoplastic therapy -- Gastrointestinal complications of chemotherapy -- Hepatotoxicity of chemotherapeutic agents -- Renal and electrolyte abnormalities due to chemotherapy -- Chemotherapy-induced peripheral neuropathy -- Vascular toxicity of antineoplastic agents -- Second malignancies after chemotherapy -- Chemotherapy in pregnancy -- Gonadal complications and teratogenicity of cancer therapy -- Central venous access for chemotherapy -- Systemic therapy for advanced melanoma -- General issues in brain tumor chemotherapy -- Chemotherapy of head and neck cancer -- Chemotherapy of lung cancer -- Breast cancer -- Gastrointestinal cancer -- Endocrine tumors -- Chemotherapy of genitourinary cancers -- Chemotherapy of gynecologic cancers -- Chemotherapy of carcinoma of unknown primary site -- Chemotherapy of bone and soft tissue sarcomas -- Chemotherapy for pediatric solid tumors -- Chemotherapy of hodgkin's lymphoma -- Non-hodgkin's lymphoma -- Acute myeloid leukemia, acute lymphoblastic leukemia, and chronic lymphocytic leukemia -- Chemotherapy of the myelodysplastic syndromes -- Management of myeloproliferative disorders and chronic myeloid leukemia -- Chemotherapy of multiple myeloma and other plasma cell disorders.

"Written for Pain Management Practitioners, Oncologists, Oncology Nurses, Nurse Practitioners, Social Workers, Pharmacologists, and Primary Care Practitioners, as well as students in these fields, this reference provides insight into chemotherapy-induced neuropathic pain cancer survivors suffer. It reviews the basic and clinical research into the normal physiology of pain transmission pathways, neuropathic pain pathology, the chemotherapeutic drug mechanisms of action and adverse effects, chemotherapy-induced neuropathy, and drug discovery efforts for treatment. Bridging the gap between theory and practice, this reference covers both basic science and clinical research, providing a unique insight into drug discovery efforts"--Provided by publisher.

Introduction, history, controversies, and definitions / Marshall D. Lindheimer ... [et al.] -- The clinical spectrum of preeclampsia / F. Gary Cunningham, James M. Roberts and Marshall D. Lindheimer -- Epidemiology of pregnancy-related hypertension / Roberta B. Ness and James M. Roberts -- Genetic factors in the etiology of preeclampsia/eclampsia / Kenneth Ward and Marshall D. Lindheimer -- The placenta in normal pregnancy and preeclampsia / Susan J. Fisher, Michael McMaster and James M. Roberts -- Angiogenesis and preeclampsia / S. Ananth Karumanchi, Isaac E. Stillman and Marshall D. Lindheimer -- Metabolic syndrome and preeclampsia / Carl A. Hubel and James M. Roberts -- Immunology of normal pregnancy and preeclampsia / Christopher W.G. Redman, Ian L. Sargent, and James M. Roberts -- Endothelial cell dysfunction and oxidative stress / Robert N. Taylor, Sandra T. Davidge and James M. Roberts -- Animal models / Rocco C. Venuto and Marshall D. Lindheimer -- Tests to predict preeclampsia / Agustin Conde-Agudelo, Roberto Romero and Marshall D. Lindheimer --Prevention of preeclampsia and eclampsia / Baha M. Sibai and F. Gary Cunningham -- Cerebrovascular (patho)physiology in preeclampsia/eclampsia / Gerda G. Zeeman, Marilyn J. Cipolla and F. Gary Cunningham -- Cardiovascular alterations in normal and preeclamptic pregnancy / Judith U. Hibbard, Sanjeev G. Shroff and Marshall D. Lindheimer -- Normal and abnormal volume homeostasis / Friedrich C. Luft, Eileen D.M. Gallery and Marshall D. Lindheimer -- Agonistic autoantibody-mediated disease / Ralf Dechend, Friedrich C. Luft and Marshall D. Lindheimer -- The kidney in normal pregnancy and preeclampsia / Kirk P. Conrad, Lillian W. Gaber and Marshall D. Lindheimer -- Platelets, coagulation, and the liver / Louise Kenny, Philip N. Baker and F. Gary Cunningham -- Chronic hypertension and pregnancy / Phyllis August and Marshall D. Lindheimer -- Antihypertensive treatment / Jason G. Umans, Edgardo J. Abalos and Marshall D. Lindheimer -- Management / Kenneth J. Leveno and F. Gary Cunningham.

Functional anatomy of the respiratory system / Donna L. Carden, Michael A. Matthay, and Ronald B. George -- Mechanics of respiration / Richard W. Light -- Alveolar ventilation, gas exchange, oxygen delivery, and acid-base physiology / Ronald B. George and Gary T. Kinasewitz -- The respiratory history and physical examination / Ronald B. George and D. Keith Payne -- Chest imaging / Dirk Sostman ... [et al.] -- Clinical pulmonary function testing, exercise testing, and disability evaluation / Richard W. Light -- Invasive diagnostic procedures / Richard W. Light and R. Michael Rodriguez -- Asthma / Mani S. Kavuru and Herbert P. Wiedemann -- Chronic obstructive pulmonary disease / James F. Donohue and Gerardo S. San Pedro -- Lung transplantation and lung volume reduction surgery / Stephanie M. Levine ... [et al.] -- Pulmonary thromboembolism and other pulmonary vascular diseases / Alejandro C. Arroliga, Michael A. Matthay, and Richard A. Matthay -- Diffuse parenchymal and alveolar lung diseases / David G. Morris ... [et al.] -- Occupational and environmental lung disease / Carrie A. Redlich and John R. Balmes -- Lung neoplasms / Lynn T. Tanoue, Darryl C. Carter, and Richard A. Matthay -- Respiratory tract infections / Michael S. Niederman and George A. Sarosi -- Pulmonary complications in the immunosuppressed patient / Boaz A. Markewitz and G. Douglas Campbell -- Diseases of the pleura, mediastinum, chest wall, and diaphragm / Richard W. Light -- Sleep-related breathing disorders / Richard B. Berry -- Pulmonary and critical care among elderly patients admitted to the intensive care unit / Cari R. Levy, Margaret A. Pisani, and E. Wesley Ely -- Nutrition and ethical principles in critical illness and injury / Annette Stralovich-Romani, C. Kres Mahutte, and John M. Luce -- General principles of managing the patient with respiratory failure / Rachel H. Dotson, Brian M. Daniel, and James A. Frank -- Acute hypercapnic respiratory failure: neuromuscular and obstructive diseases / Kamran Atabai, Michael A. Matthay, and Carolyn S. Calfee -- Acute hypoxemic respiratory failure: pulmonary edema and acute lung injury / Lorraine B. Ware and Michael A. Matthay -- Thoracic trauma, surgery and perioperative management / Michael W. Owens, Shawn A. Milligan, and Jane M. Eggerstedt -- Managing the patient with shock sepsis and multiple organ failure / Richard H. Savel, Michael A. Matthay, and Michael Gropper -- Prevention of nonpulmonary complications of intensive care / Mark D. Eisner, Michael A. Matthay, and Sanjay Saint.

Normal anatomy of the chest -- Signs and patterns of lung disease --Interstitial lung disease -- Alveolar lung disease -- Monitoring and support devices--"tubes and lines" -- Mediastinal masses -- Solitary and multiple pulmonary nodules -- Chest trauma -- Pleura, chest wall, and diaphragm -- Upper lung disease, infection, and immunity -- Atelectasis -- Peripheral lung disease -- Airways -- Unilateral hyperlucent hemithorax -- Neoplasms of the lung -- Congenital lung disease -- Pulmonary vasculature disease -- Congenital and acquired cardiac disease -- Thoracic aorta -- Self-assessment.

Chest wall lesions -- Pleural and subpleural opacities -- Pleural effusions -- Pleural thickening and pleural calcification -- Elevated diaphragm -- Shift of the mediastinum -- Widening of the mediastinum -- Anterior mediastinal mass -- Middle mediastinal mass -- Hilar enlargement -- Posterior mediastinal mass -- Atelectasis -- Segmental and lobar opacities -- Diffuse air-space opacities -- Multifocal ill-defined opacities -- Diffuse fine nodular opacities -- Fine reticular opacities -- Coarse reticular opacities (honeycomb lung) -- Solitary pulmonary nodule -- Multiple nodules and masses -- Hyperlucent thorax -- Solitary lucent defect -- Multiple lucent lesions.

General principles of psychopharmacotherapy with children and adolescents -- Sympathomimetic amines and central nervous system stimulants -- First generation/typical antipsychotic drugs -- Second generation/atypical and other antipsychotic drugs -- Antidepressant drugs -- Mood stabilizers : lithium carbonate and antiepileptics -- Antianxiety drugs -- Other drugs.

Preface --Section 1: General principles of development and the psychiatric evaluation of children and adolescents --ch. 1.Overview of development --ch. 2. Thepsychiatric evaluation --Section 2 : Axis 1 disorders usually first diagnosed in infancy, childhood, or adolescence --Part A : Developmental disorders --ch. 3.Mental retardation --ch. 4.Learning disorders --ch. 5.Pervasive developmental disorders : the autism spectrum disorders --Part B : Disruptive behavior disorders --ch. 6.Attention deficit hyperactivity disorder --ch. 7.Conduct disorder and oppositional defiant disorder --Part C : Other disorders of infancy, childhood, or adolescence --ch. 8.Separation anxiety disorder --ch. 9.Selective mutism --Part D : Tic disorders --ch. 10.Tourette and other tic disorders --Part E : Elimination disorders --ch. 11.Elimination disorders : functional encopresis and functional enuresis --Part F : Feeding and eating disorders of infancy or early childhood --ch. 12.Feeding and eating disorders of infancy or early childhood : Pica, Rumination disorder, feeding disorder of infancy or early childhood --Section 3 : General psychiatric disorders that may begin in childhood or adolescence --ch. 13.Depressive disorders : major depression, dysthymia, depression NOS --ch. 14.Juvenile onset bipolar disorder --ch. 15.Anxiety disorders : generalized anxiety, phobias and obsessive-compulsive disorder --ch. 16.Early onset schizophrenia and other psychotic disorders --ch. 17.Eating disorders : anorexia nervosa and bulimia nervosa --ch. 18.Substance use disorders --ch. 19.Trauma-related disorders --ch. 20.Adjustment disorders --Section 4 : Special clinical circumstances --ch. 21.Psychiatric emergencies in child an adolescent psychiatry --ch. 22.Child neglect and abuse --Section 5 : Treatment --ch. 23.Principles of treatment planning --ch. 24.Psychopharmacology --ch. 25.Psychosocial interventions --ch. 26.Psychoeducational interventions --ch. 27.Consultations to systems of care --Appendices --1a.Essentials of the Child and Adolescent Psychiatric Evaluation/Report --1b.Psychiatric review of symptoms --1c.Medication appointment record --1d.Abnormal involuntary movement scale (AIMS) --1e. TheSimpson-Angus Scale (SAS) --2a.Rating scales --2b.Commonly used tests : assessment of children and youth --3a.DSM-IV-TR mnemonics --4.Resources for parents --Suggested readings.

Familial influences -- Neurodevelopment and neuropsychiatric disorders -- Developmental psychopathology -- Adolescence and psychiatric disorders often beginning in adolescence -- Child-adult continuities in psychiatric disorders -- Psychosocial aspects of physical disorders -- Psychosocial aspects of specific physical conditions -- Prevention and treatment -- Services.

Inherited metabolic diseases of the nervous system / John H. Menkes and William R. Wilcox -- Mitochondrial encephalomyopathies / Harvey B. Sarnat and John H. Menkes -- Heredodegenerative diseases / John H. Menkes -- Chromosomal anomalies and contiguous-gene syndromes / John H. Menkes and Rena E. Falk -- Neuroembryology, genetic programming, and malformations of the nervous system / Harvey B. Sarnat ... [et al.] -- Perinatal asphyxia and trauma / John H. Menkes and Harvey B. Sarnat -- Infections of the nervous system / Bernard L. Maria, James F. Bale, Jr., and G. Ellis Ziel -- Autoimmune and postinfectious diseases / Agustin Legido ... [et al.] -- Postnatal trauma and injuries by physical agents / John H. Menkes and Richard G. Ellenbogen -- Toxic and nutritional disorders / John H. Menkes -- Tumors of the nervous system / Bernard L. Maria and John H. Menkes -- Neurocutaneous syndromes / Bernard L. Maria and John H. Menkes -- Cerebrovascular disorders / Cesar C. Santos and E. Steve Roach -- Paroxysmal disorders / Raman Sankar ... [et al.] -- Headaches and nonepileptic episodic disorders / A. David Rothner and John H. Menkes -- Diseases of the motor unit / John H. Menkes and Harvey B. Sarnat -- Neurologic manifestations of systemic illness / S. Robert Snodgrass -- Disorders of mental development / Marcel Kinsbourne and Frank Wood.

v. 1. Birth to age 14 -- v. 2. Adolescents ages 15 to 19.

Learning about cognitive activities -- Conceptual knowledge about cognitive activities -- Phenomenological awareness : consciousness and the development of cognitive monitoring -- Social experience as a source of information about mental events -- Patterns of influence among phenomenological awareness, social experience, and conceptual knowledge.

Part 1. Overview -- General Principles / Roderick D. Duncan -- Growth and Its Variants / Roderick D. Duncan -- Children and Young People with Disability: Management and Support / Zoë M. Dunhill -- Anesthesia and Analgesia in Children / Edward Doyle -- Paediatric Imaging / David J. Wilson and Gina M. Allen -- Part 2. Generalized Disorders -- Gait Analysis / Tim N. Theologis -- Bone, Cartilage, and Fibrous Tissue Disorders / William G. Cole -- Metabolic and Endocrine Disorders of the Skeleton / Roger Smith -- Blood Disorders and AIDS / Christopher A. Ludlam and John E. Jellis -- Infections of Bones and Joints / Klaus Parsch and Sydney Nade -- Skeletal Tuberculosis / Kenneth C. Rankin and Surendar M. Tuli -- Children's Orthopaedics in the Tropics / Sharaf B. Ibrahim and Abdul-Hamid Abdul-Kadir -- Juvenile Idiopathic Arthritis / Günther E. Dannecker and Martin N. Arbogast -- Bone Tumors / Gérard Bollini, Jean-Luc Jouve, Franck Launay, Elke Viehweger and Yann Glard, et al. -- Part 3. Neuromuscular Disorders -- Neuromotor Development and Examination / Robert A. Minns -- Hereditary and Developmental Neuromuscular Disorders / Eugene E. Bleck and James E. Robb -- Neural Tube Defects, Spina Bifida, and Spinal Dysraphism / H. Kerr Graham and Klaus Parsch -- Poliomyelitis / Wang Chow, Yun Hoi Li and Chi Yan John Leong -- Orthopaedic Management of Cerebral Palsy / James E. Robb and Reinald Brunner -- Arthrogryposis multiplex congenita / John A. Fixsen -- Part 4. Regional Disorders -- Developmental Anomalies of the Hand / Peter D. Burge -- The Shoulder and Elbow / John A. Fixsen -- Brachial Plexus Injuries Peripheral Nerve Injuries / Alain L. Gilbert and Rolfe Birch -- Leg Deformity and Length Discrepancy / John A. Fixsen, Robert A. Hill and Franz Grill -- The Limping Child / F. Stig Jacobsen and Göran Hansson -- Developmental Dysplasia of the Hip / Michael K.D. Benson and Malcolm F. Macnicol -- Legg-Calvé-Perthes Disease / Andrew M. Wainwright and Anthony Catterall -- Slipped Capital Femoral Epiphysis / Malcolm F. Macnicol and Michael K. D. Benson -- The Knee / David M. Hunt and Malcolm F. Macnicol -- The Foot / John A. Fixsen -- The Clubfoot: Congenital Talipes Equinovarus / Deborah M. Eastwood -- Pes Cavus / John A. Fixsen -- Congenital Vertical Talus (Congenital Convex Pes Valgus) / John A. Fixsen -- Congenital Disorders of the Cervical Spine / Robert N. Hensinger -- Back Pain in Children / Robert A. Dickson -- Spinal Deformities / Robert A. Dickson -- Spondylolisthesis / Robert A. Dickson -- Part 5. Fractures -- Principles of Fracture Care / Malcolm F. Macnicol and Alastair W. Murray -- Fracture Epidemiology / Lennart A. Landin -- Polytrauma in Children / Peter P. Schmittenbecher and Cathrin S. Parsch -- Management of Growth Plate Injuries / Franck Accadbled and Bruce K. Foster -- Birth and Non-accidental Injuries / Peter J. Witherow, Michael K.D Benson and Jacqueline Y.Q. Mok -- Fractures Around the Shoulder and the Humerus / J.B. Hunter -- Fractures of the Elbow and Forearm / James B. Hunter and Klaus Parsch -- Wrist and Hand Fractures / Malcolm F. Macnicol and Klaus Parsch -- Fractures of the Pelvis / Peter W. Engelhardt -- Femoral Neck Fractures / Peter W. Engelhardt -- Femoral Shaft Fractures / Klaus Parsch -- Fractures of the Knee and Tibia / Carol-C. Hasler -- Ankle Fractures / Klaus Parsch and Francisco Fernandez Fernandez -- Fractures and Dislocations of the Foot / Francisco Fernandez Fernandez -- Traumatic Disorders of the Cervical Spine / Robert N. Hensinger -- Fractures of the Thoracic and Lumbar Spine / Robert N. Hensinger and Clifford L. Craig.

Bioethics of trust /Julia Tao --Chinese health care policy /H. Tristram Engelhardt, Jr. and Aaron E. Hinkley --Towards a Confucian approach to health care allocation in China /Yongfu Cao ...Trust is the core of the doctor-patient relationship /Benfu Li and Linying Hu --Medical resources, the market, and the develpment of private-run hospitals China /Xiaoyang Chen ... [et al.] --China beware /H. Tristram Engelhardt, Jr --Confucian trust, market and health care reform /Julia Tao --Pursuit of an efficient, sustainable health care system in China /Ana Iltas --Reconstructionist Confucian approach to Chinese health care /Ruiping Fan --Health care services, markets, and the Confucian moral tradition /Zhizheng Du --Markets trust, and the nurturing of a culture of responsibility /Frederic H. Fransen --Fostering professional virtue in the market /Jeremy Garrett --On the reform of health care reform /Ren-Zong Qiu --Is Singapore's healthcare system morally problematic? /Justin Ho.

When SARS broke out in January 2003, author Greenfeld was the editor of Time Asia in Hong Kong, just a few miles from the epicenter of the outbreak. After vague, initial reports of terrified Chinese emptying pharmacy shelves and boiling vinegar to "purify" the air in nearby Guangdong province, Greenfeld and his staff soon found themselves immersed in the story of a lifetime. His scientific thriller takes readers on a ride that blows through the Chinese government's effort to cover up the disease. Greenfeld tracks this mysterious killer outbreak, from the bedside of one of the first Chinese victims to overwhelmed hospital wards crashing from the onslaught of cases, from cutting-edge labs where researchers struggle to identify the virus to the war rooms at the World Health Organization headquarters in Geneva.--From publisher description.

Chinese medicinal herbs: phytopharmacology and therapeutic values -- Phyletic relationships between Chinese and Western medicinal herbs.

1. Chlamydia pneumoniae: prospects and predictions for an emerging pathogen / Scot P. Ouellette and Gerald I. Byrne -- 2. Morphology of Chlamydia pneumoniae / Naoyuki Miyashita and Akira Matsumoto -- 3. Cell and molecular biology of Chlamydia pneumoniae / Gunn Christiansen, Brian Vandahl, and Svend Birkelund -- 4. Antibiotic susceptibility and treatment of Chlamydia pneumoniae infections / Margaret R. Hammerschlag -- 5. Pneumonia caused by Chlamydia pneumoniae / Francesco Blasi ... [et al.] -- 6. Chlamydia detection in blood / Yoshimasa Yamamoto -- 7. Chlamydia pneumoniae infection and diseases: imunity to Chlamydia pneumoniae / Heljä-Marja Surcel -- 8. Vaccines against Chlamydia pneumoniae: can they be made? / Martin E. Rottenberg, Antonio Gigliotti Rothfuchs, and Hans Wigzell -- 9. Chlamydia pneumoniae and atherosclerosis - an overview of the Association / Joseph Ngeh and Sandeep Gupta --10. The biology of Chlamydia pneumoniae in cardiovascular disease pathogenesis / Scot P. Ouellette ... [et al.] -- 11. Animal models of Chlamydia pneumoniae infection and atherosclerosis / Ignatius W. Fong -- 12. Antiinfective trials for the treatment of Chlamydia pneumoniae in coronary artery disease / Joseph B. Muhlestein -- 13. Chlamydia pneumoniae and myocarditis / Håkan G. Gnarpe and Judy A. Gnarpe -- 14. Chlamydia pneumoniae as a candidate pathogen in multiple sclerosis / Charles W. Stratton and Subramaniam Sriram -- 15. Chlamydia pneumoniae in the pathogenesis of Alzheimer's disease / Brian J. Balin ... [et al.] -- 16. Chlamydia pneumoniae and inflammatory arthritis / Judith A. Whittum-Hudson, H. Ralph Schumacher, and Alan P. Hudson -- 17. Role of Chlamydia pneumoniae as an inducer of asthma / David L. Hahn -- 18. Respiratory tract infections caused by C. pneumoniae in pediatric patients / Kazunobu Ouchi.

Chocolate as medicine: an introduction -- Chocolate as medicine: seeking evidence throughout history -- Chocolate and healing in pre-Columbian Mesoamerican culture -- Cacao transported to Europe as medicine -- Expanding chocolate's use as medicine -- Chocolate and nutritional health: industrial era through WWII -- Modern chocolate science and human health -- Epilogue: prognosticating chocolate's future as medicine -- Appendices.

Palliative care in acute care hospitals / Randy Hebert, Nicole Fowler, and Robert Arnold -- Palliative care in nursing facilities / Brenda Mamber -- Patient-centered palliative care in the home / Francine Rainone and Marlene McHugh -- Hospice care / Carolyn Cassin -- The role of cancer rehabilitation in the maintenance of functional integrity and quality of life / Andrea Cheville, Vivek Khemka, and Sean O'Mahony -- HIV/AIDS and palliative care : models of care and policy issues / Peter A. Selwyn ... [et al.] -- Palliative care and chronic obstructive lung disease / Manoj Karwa, Alpana Chandra, and Adnan Mirza -- Palliative care and chronic heart failure / Vikas Bhatara ... [et al.] -- Palliative care for patients with Alzheimer's dementia : advance care planning across transition points / Jennifer Rhodes-Kropf -- Children and issues around palliative care / Tamara Vesel, Rita Fountain, and Joanne Wolfe -- Palliative care and the elderly : complex case management / Sean O'Mahoney and Franca Martino-Starvaggi -- The business of palliative medicine : business planning, models of care and program development / Ruth Lagman and Declan Walsh -- Palliative care and quality management : the core principles of quality improvement and their utility in designing clinical programs for end of life care and complex case management models / Sarah Myers and Arthur E. Blank -- Ethics and the delivery of palliative care / Linda Faber-Post.

Normal electrocardiogram: origin and description -- Atrial abnormalities -- Ventricular enlargement -- Left bundle branch block -- Right bundle branch block -- Other intraventricular conduction disturbances -- Acute ischemia: electrocardiographic patterns -- Myocardial infarction and electrocardiographic patterns simulating myocardial infarction -- Non-Q wave myocardial infarction, non-ST elevation myocardial infarction, unstable angina pectoris, myocardial ischemia -- Stress test -- Pericarditis and cardiac surgery -- Diseases of the heart and lungs -- Sinus rhythms -- Atrial rhythms -- Atrial flutter and atrial fibrillation -- Atrioventricular junctional rhythms -- Ventricular arrhythmias -- Torsade de pointes, ventricular fibrillation, and differential diagnosis of wide QRS tachycardias -- Atrioventricular block; concealed conduction; gap phenomenon -- Ventricular preexcitation (Wolff-Parkinson-White Sydrome and its variants) -- Effect of drugs on the electrocardiogram -- Electrolytes, temperature, central nervous system diseases, and miscellaneous effects -- T wave abnormalities -- QT interval, U wave abnormalities, and cardiac alternans -- Misplaced of leads and electrocardiographic artifacts -- Electrocardiography of artificial electronic pacemakers -- Ambulatory electrocardiography -- Normal electrocardiograms in the fetus, infants, and children -- Abnormal electrocardiograms in the fetus, infants, and children -- The electrocardiogram in congenital heart disease -- Cardiac arrhythmias in the fetus, infants, children, and adolescents with congenital heart disease.

Preparation of chromatin assembly extracts from preblastoderm Drosophila embryos / Edgar Bonte and Peter B. Becker -- Analysis of reconstituted chromatin using a solid-phase approach / Raphael Sandaltzopoulos and Peter B. Becker -- In vivo chromatin decondensation assays : molecular genetic analysis of chromatin unfolding characteristics of selected proteins / Sherry L. Winter, Philip Wong, and Mark G. Alexandrow -- DNA methyltransferase probing of chromatin structure within populations and on single molecules / Carolina Pardo ... [et al.] -- Visualization of the expression of HMGN nucleosomal binding proteins in the developing mouse embryo and in adult mouse tissues / Takashi Furusawa and Michael Bustin -- Drug-induced premature chromosome condensation (PCC) protocols : cytogenetic approaches in mitotic chromosome and interphase chromatin / Eisuke Gotoh -- Analysis of DNA topology in yeast chromatin / Randall H. Morse -- Preparation and analysis of uniquely positioned mononucleosomes / Daria A. Gaykalova ... [et al.] -- Monitoring DNA breaks in optically highlighted chromatin in living cells by laser scanning confocal microscopy / Michael J. Kruhlak, Arkady Celeste, and André Nussenzweig -- Methods to study transcription-coupled repair in chromatin / Hélène Gaillard, Ralf Erik Wellinger, and Andrés Aguilera -- Cytometric analysis of DNA damage : phosphorylation of histone H2AX as a marker of DNA double-strand breaks (DSBs) / Toshiki Tanaka ... [et al.] -- Detection of DNA damage induced by topoisomerase II inhibitors, gamma radiation, and crosslinking agents using the comet assay / Lori A. Hazlehurst -- Analysis of genomic aberrations using comparative genomic hybridization of metaphase chromosomes / Melanie Carless -- In vitro replication assay with mammalian cell extracts / Wasia Rizwani and Srikumar P. Chellappan -- Investigation of genomic methylation status using methylation-specific and bisulfite sequencing polymerase chain reaction / Melanie Carless -- Biochemical analysis of arginine methylation in transcription / Marc Tini, Hina Naeem, and Joseph Torchia -- In vitro histone demethylase assays / Kenji Kokura and Jia Fang -- Histone chaperone as coactivator of chromatin transcription : role of acetylation / Shrikanth S. Gadad ... [et al.] -- Histone deacetylase activity assay / Zhigang Yuan ... [et al.] -- In vitro and in vivo assays for studying histone ubiquitination and deubiquitination / Ling Zhai, Heui-Yun Joo, and Hengbin Wang -- Detection of histone H3 phosphorylation in cultured cells and tissue sections by immunostaining / Jaya Padmanabhan -- Chromatin immunoprecipitation assays : analyzing transcription factor binding and histone modifications in vivo / Smitha Pillai, Piyali Dasgupta, and Srikumar P. Chellappan -- ChIP on Chip assays : genome-wide analysis of transcription factor binding and histone modifications / Smitha Pillai and Srikumar P. Chellappan -- ChIP-on-Chip analysis methods for Affymetrix tiling arrays / Sean J. Yoder and Steven A. Enkemann -- Non-radioactive assay methods for the assessment of telomerase activity and telomere length / Partha P. Banerjee and Shankar Jagadeesh -- Detecting ATM-dependent chromatin modification in DNA damage and heat shock response / Sandeep Misri, Shruti Pandita, and Tej K. Pandita.

Relating chromatography to separations -- Simple separation methods -- Equilibrium processes in separations -- The molecular basis of separation -- Mass transport and separation -- Chromatographic methods -- Paper chromatography -- Thin-layer chromatography -- Gas chromatography -- High-pressure liquid chromatography -- Evolving methods and method selection.

Biallelic gene knockouts in Chinese hamster ovary cells / Naoko Yamane-Ohnuki, Kazuya Yamano, and Mitsuo Satoh -- Highly proficient gene targeting by homologous recombination in the human pre-B cell line Nalm-6 / Noritaka Adachi, Aya Kurosawa, and Hideki Koyama -- Robust cell line development using meganucleases / Jean-Pierre Cabaniols and Frédéric Pâques -- Design and testing of zinc finger nucleases for use in mammalian cells / Matthew Porteus -- Gene targeting in Drosophila and Caenorhabditis elegans with zinc-finger nucleases / Dana Carroll ... [et al.] -- Orpheus recombination : a comprehensive bacteriophage system for murine targeting vector construction by transplacement / Knut Woltjen ... [et al.] -- Transposition -mediated mutagenesis in somatic cells : identification of transposon-genomic DNA junctions / David A. Largaespada and Lara S. Collier -- Insertional mutagenesis of the mouse germline with sleeping beauty transposition / Junji Takeda, Zsuzsanna Izsvák, and Zoltán Ivics -- Conditional gene trapping using the FLEx system / Thomas Floss and Frank Schnütgen -- Steps toward targeted insertional mutagenesis with class II transposable elements / Sareina Chiung-Yuan wu ... [et al.] -- Targeting integration of the Saccharomyces Ty5 retrotransposon / Troy L. Brady, Clarice L. Schmidt, and Daniel F. Voytas -- Site-specific chromosomal integration mediated by [phi]C31 integrase / Annahita Keravala and Michele P. Calos-- Triplex-mediated gene modification / Erica B. Schleifman, Joanna Y.Chin, and Peter M. Glazer -- Allelic exchange of unmarked mutations in Mycobacterium tuberculosis / Martin S. Pavelka, Jr. -- Mycobacterial recombineering Julia C. van Kessel and Graham F. Hatfull -- Chromosomal engineering of Clostridium perfringens using group II introns / Phalguni Gupta and Yue Chen.

Mechanical approaches to elucidate mechanisms of chromosome condensation at the nano- and microlevels / Kazushige Kawabata ... [et al.] -- Development of novel AFM probes for chromosome manipulation / Masato Saito, Gen Hashiguchi and Eiichi Tamiya -- Microchamber array-based sequence-specific DNA detection from a single chromosome via trace volume PCR / Masato Saito and Eiichi Tamiya -- On-chip chromosome sorter using electric and magnetic fields / Takahito Inoue ... [et al.] -- Fluorescence microscopy for analysis of chromosome dynamics / Sachihiro Matsunaga -- Fluorescence in situ hybridization (FISH) as a tool for comparative genomics: application of FISH to studies of chromosome evolution in vertebrates / Yoichi Matsuda ... [et al.] -- Immunocytochemistry for analyzing chromosomes / Osamu Hoshi ... [et al.] --Proteome analysis of human metaphase chromosomes / Kiichi Fukui and Susumu Uchiyama -- Antipeptide antibodies for examining the conformation and molecular assembly of an intracellular protein / Masatoshi Nakagawa ... [et al.] -- Structure and interactions of the imitation SWI-type chromatin-remodeling complex, ATP-dependent chromatin-assembly facter / Tadayasu Ohkubo ... [et al.] -- Dynamic and functional analysis of chromosomal proteins / Nobuko Ohmido ... [et al.] -- Development of a sustainable chromosome imaging database / Kenji Taniguchi ... [et al.] -- Image database and image analysis of chromosome information / Shin-ichi Toyabe ... [et al.].Transmission and scanning electron microscopy of mammalian metaphase chromosomes / Sumire Inaga, Keiichi Tanaka and Tatsuo Ushiki -- Atomic force microscopy of human chromosomes in relation to their higher-order structure / Osamu Hoshi, Daisuke Fukushi and Tatsuo Ushiki -- Mechanism of higher-order chromatin folding revealed by AFM observation of in vitro reconstituted chromatin / Kohji Hizume ... [et al.] -- Scanning near-field optical/atomic force microscopy as a tool for simultaneous specification of chromosome topography and particular gene location on the nanometer scale / Motoharu Shichiri ... [et al.] -- Isolation of human and plant chromosomes as nanomaterials / Susumu Uchiyama, Tomoyuki Doi and Kiichi Fukui --

Current issues and challenges in chronic disease control / Matthew McKenna and Janet Collins -- Methods in chronic disease epidemiology / Patrick L. Remington, Ross Brownson and David Savitz -- Intervention methods for chronic disease control / Robert J. McDermott ... [et al.] -- Chronic disease surveillance / Mark V. Wegner, Angela Rohan and Patrick L. Remington -- Tobacco use / Corinne G. Husten -- Diet and nutrition / Nasuh Malas, Kathleen M. Tharp and Susan B. Foerster -- Physical activity / Barbara E. Ainsworth and Caroline A. Macera -- Alcohol use / Mary C. Dufour -- Obesity and overweight / Deborah A. Galuska and William H. Dietz -- Diabetes / Donald B. Bishop, Patrick J. O'Connor and Jay Desai -- High blood pressure / Leonelo E. Bautista -- High blood cholesterol / Heather M. Johnson and Patrick E. McBride -- Cardiovascular disease / Craig J. Newschaffer, Longjian Liu and Alan Sim -- Cancer / Ross C. Brownson and Corinne Joshu -- Chronic respiratory diseases / Henry A. Anderson and Mark Werner -- Mental disorders / Danny Wedding -- Neurological disorders / Edwin Trevathan -- Arthritis and other musculoskeletal diseases / Rosemarie Hirsch and Marc C. Hochberg -- Chronic liver disease / Adnan Said and Jennifer Wells -- Kidney disease / Vishnu Moorthy and Jonathan B. Jaffery.

Overview of chronic disease management / Jim Nuovo -- Self-management in chronic illness / Bridget R. Levich -- Use of group visits in the treatment of the chronically ill / Edward B. Noffsinger -- Chronic disease care: creating practice change / Thomas A. Balsbaugh -- Medication management in chronic diseases / Timothy W. Cutler and Marilyn Stebbins -- Providing culturally competent chronic disease management: diabetes mellitus / David Stempel and Bruce Allen Chernof -- Type 2 diabetes / Jim Nuovo -- Asthma / Samuel Louie -- Heart failure / William Lewis and Jim Nuovo -- Osteoarthritis / Ernesto Zatarain -- Obesity / Jim Nuovo -- Depression / Jim Nuovo -- Chronic pain / Jim Nuovo.

Chronic Diseases: Epidemiology and Health Care Disparities -- Health Care Costs -- Living with a Chronic Disease -- Diabetes Mellitus -- Rheumatoid Arthritis, Osteoarthritis, Osteoporosis, Fibromyalgia, and Low Back Pain -- Cardiovascular Disease -- Cancer.

Epidemiology, Health Services Utilization, and Costs -- Chromosomal Abnormalities -- Autism -- Cerebral Palsy -- Attention-Deficit Hyperactivity Disorder -- Sensory Integration Dysfunction -- Conduct Disorder and Oppositional Defiant Disorder -- Depressive Disorders in Children and Adolescents -- Eating Disorders -- Childhood and Adolescent Obesity -- Diabetes Mellitus -- Juvenile Arthritis -- Infants, Children, and Adolescents Affected by HIV/AIDS.

Chapter 1. Interferon and the 2-5A/Pathway / Lionel Bastide, Edith Demettre, Camille Martinand-Mari, and Bernard Lebleu -- Chapter 2. Ribonuclease L: Overview of a Multifaceted Protein / Patrick Englebienne, C. Vincent Herst, Simon Roelens, Anne D'Haese, Karim El Bakkouri, Karen De Smet, Marc Frémont, Lionel Bastide, Edith Demettre, and Bernard Lebleu -- Chapter 3. A 37-kDa RNase L: A Novel Form of RNase L Associated with Chronic Fatigue Syndrome / Robert J. Suhadolnik, Susan E. Shetzline, Camille Martinand-Mari, and Nancy L. Reichenbach -- Chapter 4. Ribonuclease L Inhibitor: A Member of the ATP-Binding Cassette Superfamily / Patrick Englebienne, C. Vincent Herst, Anne D'Haese, Kenny De Meirleir, Lionel Bastide, Edith Demettre, and Bernard Lebleu -- Chapter 5. The 2-5A Pathway and Signal Transduction: A Possible Link to Immune Dysregulation and Fatigue / Patrick Englebienne, C. Vincent Herst, Marc Frémont, Thierry Verbinnen, Michel Verhas, and Kenny De Meirleir -- Chapter 6. Immune Cell Apoptosis and Chronic Fatigue Syndrome / Marc Frémont, Anne D'Haese, Simon Roelens, Karen De Smet, C. Vincent Herst, and Patrick Englebienne -- Chapter 7. RNase L, Symptoms, Biochemistry of Fatigue and Pain, and Co-Morbid Disease / Neil R. McGregor, Pascale De Becker, and Kenny De Meirleir -- Chapter 8. CFS Etiology, the Immune System, and Infection / Kenny De Meirleir, Pascale De Becker, Jo Nijs, Daniel L. Peterson, Garth Nicolson, Roberto Patarca-Montero, and Patrick Englebienne -- Chapter 9. Current Advances in CFS Therapy / Pascale De Becker, Neil R. McGregor, Karen De Smet, and Kenny De Meirleir -- Chapter 10. From Laboratory to Patient Care / Kenny De Meirleir, Daniel L. Peterson, Pascale De Becker, and Patrick Englebienne.

The organ -- Cells in the liver: functions in health and disease -- Liver physiology -- Assessment of liver function in clinical practice -- Physiology of the splanchnic and hepatic circulations -- Fibrosis as a major mechanism of chronic liver disease -- Stem cells and chronic liver failure: potential new therapeutics -- The role of inflammatory mediators in liver failure -- Genomics of the liver in health and disease -- Effects of liver failure on organ systems -- Hepatic encephalopathy and alterations of cerebral function -- Bacterial translocation and alterations of the digestive system -- SIRS, bacterial infections, and alterations of the immune system -- Regulation of the extracellular fluid volume and renal function -- The heart in chronic liver failure -- Haemostasis abnormalities in chronic liver failure -- The systemic and splanchnic circulations -- Hepatic microcirculation -- Angiogenesis and vascular growth in liver diseases -- Pulmonary alterations in chronic liver failure -- Adrenal function in chronic liver failure -- Management of chronic liver failure -- Antibiotic prophylaxis and management of bacterial infections -- Management of ascites and hyponatremia -- Management of renal failure -- Correction of abnormalities of haemostasis in chronic liver disease -- The treatment and prevention of variceal bleeding -- Extracorporeal artificial liver support systems -- Issues in transplantation of patients with chronic liver failure -- Chronic liver disease in the intensive care.

Origin and nature of chronic lymphocytic leukemia B cells / Nicolas Chiorazzi and Manlio Ferrarini -- Gene expression profiling in the study of CLL / Ulf Klein -- Molecular pathogenesis / Arianna Bottoni, Carlo M. Croce, and George A. Calin -- Chronic lymphocytic leukemia and the B cell receptor / Marta Muzio and Federico Caligaris-Cappio -- Etiology of CLL : the role of MBL / Paolo Ghia and Andrew C. Rawstron -- Apoptosis dysregulation in CLL / Victoria Del Gaizo Moore and Anthony Letai -- Differential diagnosis, staging, and prognostic factors / Thorsten Zenz, Hartmut Dohner, and Stephan Stilgenbauer -- Frontline therapy of chronic lymphocytic leukemia / Barbara Eichhorst and Michael Hallek -- Treatment of patients with relapsed or refractory chronic lymphocytic leukemia / Karen W.L. Yee, Michael J. Keating, and Susan M. O'Brien -- New therapies in chronic lymphocytic leukemia / John C. Byrd ... [et al.] -- Stem cell transplantation in CLL / John G. Gribben -- Gene therapy, vaccines, and immune modulation / William G. Wierda -- Prolymphocytic leukemias / Claire E. Dearden -- CLL specific complications : autoimmunity and Richter's transformation / Dennis A. Carney and John F. Seymour -- Infectious complications in patients with chronic lymphocytic leukemia / Elias Anaissie.

Why more research into molecular and cellular mechanisms of COPD is needed -- Inflammation in lung parenchyma -- Small airways disease in COPD -- Asthma vs. COPD: cellular and molecular differences -- Airway mucus secretion -- Macrophages -- Neutrophils -- Epithelial cells -- T-Lymphocytes -- Inflammatory mediators -- Oxidative stress -- Proteinases in COPD -- Antiproteases -- Corticosteroid resistance in COPD -- Molecular genetics -- Mechanisms of systemic effects -- Mechanisms of exacerbations of chronic obstructive pulmonary disease -- Mechanisms of pulmonary vascular changes -- Therapeutic implications and future developments.

Summary of pain management issues: frequent concerns in treating chronic pain patients -- Pathogenesis of chronic pain -- Headache -- Cervical and lumbar pain -- Abdominal pain -- Arthritis -- Neuropathic pain -- Myofascial pain -- Fibromyalgia -- Pediatric pain -- Pregnancy and pain -- Geriatrics and chronic pain -- Gender and ethnic issues -- Psychological comorbidity -- Obesity and chronic pain -- Opioids in chronic pain.

Introduction: the Camel Man and me -- Culture -- Pro bono publico -- Tobacco as much as bullets -- Engineering consent -- Science -- More doctors smoke Camels -- The causal conundrum -- Constructing controversy -- Politics -- The surgeon general has determined -- Congress : the best filter yet -- Your cigarette is killing me -- Law -- Nicotine is the product -- Mr. Butts goes to Washington -- The trials of big tobacco -- Globalization -- Exporting an epidemic -- Epilogue: the crime of the century -- References -- Note on sources -- Acknowledgements -- Index.

Genetic approaches to circadian clocks -- Tracking circadian control of gene activity -- Molecular cycles : clock protein rhythms -- Anatomical representation of neural clocks -- Mosaic circadian systems -- Peripheral circadian clocks -- Cell and tissue culture system -- Intercellular signaling -- Photoresponsive clocks -- Sleeping flies -- Circadian biology of populations -- Circadian clocks affecting noncircadian biology.

Basic protocols for drosophila S2 cell line: maintenance and transfection / M. Fernanda Ceriani -- Co-immunoprecipitation on drosophila cells in culture / M. Fernanda Ceriani -- Basic protocols for zebrafish cell lines: maintenance and transfection / Daniela Vallone ... [et al.] -- Manipulation of mammalian cell lines for circadian studies / Filippo Tamanini -- Reporter assays / M. Fernanda Ceriani -- Use of firefly luciferase activity assays to monitor circadian molecular rhythms in vivo and in vitro / Wangjie Yu and Paul E. Hardin -- Suprachiasmatic nucleus cultures that maintain rhythmic properties in vitro / K. Tominaga-Yoshino, T. Ueyama, and H. Okamura -- RNA in situ hybridizations on drosophila whole mounts / Corinna Wulbeck and Charlotte Helfrich-Forster -- In situ hybridization of suprachiasmatic nucleus slices / Horacio O. de la Iglesia -- Immunohistochemistry in drosophila: sections and whole mounts / Charlotte Helfrich-Forster -- Immunocytochemistry on suprachiasmatic nucleus slices / Marta Muñoz Llamosas -- Immunofluorescence analysis of circadian protein dynamics in cultured mammalian cells / Filippo Tamanini.Light, photoreceptors, and circadian clocks / Russell G. Foster, Mark W. Hankins, and Stuart N. Peirson -- Statistical analysis of biological rhythm data / Harold B. Dowse -- Rhythmic conidiation in Neurospora crassa / Cas Kramer -- Monitoring and analyzing drosophila circadian locomotor activity / Mauro A. Zordan, Clara Benna, and Gabriella Mazzotta -- Automated video image analysis of larval zebrafish locomotor rhythms / Gregory M. Cahill -- Locomotor activity in rodents / Gianluca Tosini -- Analysis of circadian leaf movement rhythms in Arabidopsis thaliana / Kieron D. Edwards and Andrew J. Millar -- Detection of rhythmic bioluminescence from luciferase reporters in cyanobacteria / Shannon R. Canales ... [et al.] -- Analysis of rhythmic gene expression in adult drosophila using the firefly-luciferase reporter gene / Ralf Stanewsky -- Monitoring circadian rhythms in Arabidopsis thaliana using luciferase reporter genes / Anthony Hall and Paul Brown -- Specialized techniques for site-directed mutagenesis in cyanobacteria / Eugenia M. Clerico, Jayna L. Ditty, and Susan S. Golden -- Novel strategies for the identification of clock genes in neurospora with insertional mutagenesis / Kruno Sveric ... [et al.] -- Mutagenesis with drosophila / Patrick Emery -- Mutagenesis in arabidopsis / Jodi Maple and Simon G. Moller -- Yeast two-hybrid screening / Jodi Maple and Simon G. Moller --Microarrays: quality control and hybridization protocol / Ken-ichiro Uno and Hiroki R. Ueda -- Microarrays: statistical methods for circadian rhythms / Rikuhiro Yamada and Hiroki R. Ueda -- Identification of clock genes using difference gel electrophoresis / Natasha A. Karp and Kathryn S. Lilley -- Isolation of total RNA from Neurospora mycelium / Cas Kramer -- RNA extraction from drosophila heads / Patrick Emery -- Extraction of plant RNA / Michael G. Salter and Helen E. Conlon -- RNA extraction from mammalian tissues / Stuart N. Peirson and Jason N. Butler -- Northern analysis of sense and antisense fequency RNA in Neurospora crassa / Cas Kramer -- RNase protection assay / Patrick Emery -- Quantitative polymerase chain reaction / Stuart N. Peirson and Jason N. Butler -- Protein extraction, fractionation, and purification from cyanobacteria / Natalia B. Ivleva and Susan S. Golden -- Protein extraction from drosophila heads / Patrick Emery -- Plant protein extraction / Helen E. Conlon and Michael G. Salter -- Protein extraction from mammalian tissues / Choogon Lee -- Western blotting / Choogon Lee -- Co-immunoprecipitation assay / Choogon Lee -- In vitro phosphorylation and kinase assays in Neurospora crassa / Lisa Franchi and Giuseppe Macino --

Ventilation / Tom Whitehead and Arthur S. Slutsky -- Lung Injury / Timothy Evans and Julius Cranshaw -- The Heart / David Treacher -- Severe Traumatic Brain Injury / Hülya Bayir, Kimberly D. Statler, Margaret A. Satchell, Randall A. Ruppel, Robert S.B. Clark and Patrick M. Kochanek -- The Gut and Its Role in Circulatory Shock / Ulf H. Haglund -- Renal Support / Mark G.A. Palazzo -- The Liver in Critical Illness / Felicity Hawker -- Burns / David N. Herndon, Robert E. Barrow, Somes C. Guha and Jay K. Bhama -- Trauma / Frederick A. Moore -- Clinical Sepsis / David Bihari -- Nutrition and Metabolism / Jan Wernerman -- Fluids / Malcolm Fisher -- Infection in the Intensive Care Unit / Dennis G. Maki -- Infectious Diseases: An Intensive Care Clinician's Perspective / Neil Soni -- Vasoactive and Cardiotonic Drugs / Jean-Louis Vincent -- Pain Relief and Sedation in Intensive Care / Bernadette Currer and Maire Shelly -- Monitoring / E. Makings and C.J. Hinds -- Scoring Systems / Derek C. Angus -- Ethics / Charles L. Sprung -- Cytokines / Helen F. Galley and Nigel R. Webster -- Pediatric Critical Care / Bradley P. Fuhrman -- Recent Papers / Michelle Hayes and Neil Soni -- Frequently Cited Papers in Critical Care.

Perspectives on General Aging / Robert J. Pignolo -- History of Geriatric Medicine / Mary Ann Forciea -- Palliative Care of Older Patients / Jennifer Kapo -- Home-Based Care of the Older Patient / Mary Ann Forciea and Jean Yudin -- Education of Health Professionals / Kathy L. Egan -- Dementia / Jason H. Karlawish -- Delirium / Jerry C. Johnson -- Falls / Lesley S. Carson -- Urinary Incontinence / Mary Ann Forciea -- Osteoporosis / Robert J. Pignolo -- Nutrition / Joan Weinryb -- Health Screening and Disease Prevention / Vivian S. Argento -- Osteoarthritis / Edna P. Schwab -- Pressure Ulcers / Mary Ann Forciea -- Depression / Monica K. Crane.

Ch. 1. Global climate change and health: an old story writ large -- Ch. 2. Weather and climate: changing human exposures -- Ch. 3. International consensus on the science of climate and health: the IPCC third assessment report -- Ch. 4. Looking to the future: challenges for scientists studying climate change and health -- Ch. 5. Impacts on health of climate extremes -- Ch. 6. Climate change and infectious diseases -- Ch. 7. How much disease could climate change cause? -- Ch. 8. Stratospheric ozone depletion, ultraviolet radiation and health -- Ch. 9. National assessments of health impacts of climate change: a review -- Ch. 10. Monitoring the health effects of climate change -- Ch. 11. Adaptation and adaptive capacity in the public health context -- Ch. 12. From science to policy: developing responses to climate change -- Ch. 13. Conclusions and recommendations for action.

ch. 1. Introduction : climate change and human well-being /Inka Weissbecker --Part I. The impact of climate change --ch. 2. The threat of climate change : psychological response, adaptation, and impacts /Joseph P. Reser, Shirley A. Morrissey, and Michelle Ellul --ch. 3. Chronic environmental change : emerging 'psychoterratic' syndromes /Glenn Albrecht --ch. 4. Extreme weather-related events : implications for mental health and well-being /David M. Simpson, Inka Weissbecker, and Sandra E. Sephton --ch. 5. Humanitarian crisis : the need for cultural competence and local capacity building /Inka Weissbecker and Jennifer Czincz --ch. 6. Security and conflict : the impact of climate change /Chad Michael Briggs and Inka Weissbecker --Part II. Specific populations --ch. 7. Women and climate change : vulnerabilities and challenges /anita L. Wenden --ch. 8. Climate change refugees /Michael Hollifield, Mind Thompson Fullilove, and Stevan E. Hobfoll --Part III. Guidance and recommendations --ch. 9. Resilience, spirituality and postraumatic growth : reshaping the effects of climate change /Tamasin Ramsay and Lenore Manderson --ch. 10. Climate change, resilience and transformation : challenges and opportunities for local communities /Taegen Edwards and John Wiseman --ch. 11. conclusions : implications for practice, policy, and further research /Inka Weissbecker.

Visual system -- Cornea and sclera -- Uvea -- Retina -- Crystalline lens -- Aqueous and vitreous humors -- Ocular embryology -- Bones of the skull and orbit -- Ocular adnexa and lacrimal system -- Extraocular muscles -- Orbital blood supply -- Cranial nerve innervation of ocular structures -- Visual pathway -- Autonomic innervation of ocular structures.

The thorax: part I. the thoracic wall -- The thorax: part II. the thoracic cavity -- The abdomen: part I. the abdominal wall -- The abdomen: part II. the abdominal cavity -- The pelvis: part I. the pelvic walls -- The pelvis: part II. the pelvic cavity -- The perineum -- The upper limb -- The lower limb -- The head and neck -- The back.

1Visual system --2Cornea and sclera --3Uvea --4Retina --5Crystalline lens --6Aqueous and vitreous chambers --7Ocular embryology --8Bones of the skull and orbit --9Ocular adnexa and lacrimal system --10Extraocular muscles --11Orbital blood supply --12Cranial nerve innervation of ocular structures --13Visual pathway --14Autonomic innervation of ocular structures.

The physiology and pathology of bone -- Diagnosis and investigation -- Osteoporosis -- Osteomalacia and rickets -- Parathyroids and the skeleton -- Paget disease -- Neoplastic disease and other non-parathyroid causes of hypercalcaemia -- Osteogenesis imperfecta -- Chondrodysplasias -- Osteopetrosis and osteosclerosis -- Marfan syndrome and related disorders -- Ehlers-Danlos syndrome and related disorders -- Enzyme defects and the skeleton -- Fibrous dysplasia -- Fibrogenesis imperfecta ossium and other disorders of mineralization -- Ectopic mineralization -- Recent advances.

History of hypnosis -- Phenomena of suggestion and hypnosis -- Theories on hypnosis -- Misconceptions about hypnosis -- Suggestibility tests -- Factors that influence susceptibility to hypnosis -- Laws of suggestion -- Recognition of the depth of the hypnotic state -- Clinical observations and management of various depths of hypnosis -- Hindrances to hypnotic induction -- Practical hints for hypnotic induction -- Preinduction talk -- Authoritarian or direct technics of hypnosis -- Permissive or indirect technics -- Deepening technics -- Autohypnosis -- Autogenic training -- Group hypnosis -- Antisocial aspects of hypnosis -- Dangers from hypnosis -- Precautions in the use of hypnosis -- Precautions in dehypnotization -- Medical training, legal and ethical aspects of hypnosis -- Religious attitudes: comparative evaluation with hypnosis -- Magic, spiritualistic faith-healing, and hypnosis -- The dynamics of faith, placebo effect, and hypnosis -- Biofeedback, meditation, and altered states of consciousness -- Neurophysiologic mechanisms in mediation of emotions at nonhypnotic and hypnotic levels -- Psychophysiologic mechanisms in the production of hypnotic phenomena: relation to belief and conviction -- Relationship of semantics, communication, and perception to hypnosis -- Learning theory, hypnosis, behavior modification, and imagery conditioning -- Some relationships of the physical and behavioral sciences to psychotherapy and hypnosis -- Hypnosis in internal medicine -- Hypnosis in surgery and anesthesiology -- Pain, acupuncture, and hypnosis -- Hypnosis in obstetrics -- Hypnosis in gynecology -- Hypnosis in dermatology -- Hypnotherapy in physical rehabilitation of neuromuscular disorders -- Hypnosis in ophthalmology, otolaryngology, and rhinology -- Hypnosis in genitourinary conditions -- Hypnosis in oncology -- Hypnosis in pediatrics -- Hypnosis in orthopedics -- Hypnosis in the removal of habit patterns -- Hypnodontics: hypnosis in dentistry -- Miscellaneous indications for hypnosis -- Practical hints in hypnodiagnosis -- Practical hints in hypnotherapy -- Specialized hypnotic technics -- Comparative evaluation and criticisms of hypnotherapy and psychoanalysis -- Failures in hypnotherapy.

Clinical applications of plasma Epstein-Barr virus DNA analysis and protocols for the quantitative analysis of the size of circulating Epstein-Barr virus DNA / K.C. Allen Chan and Y.M. Dennis Lo -- Molecular analysis of circulating RNA in plasma / Nancy B.Y. Tsui, Enders K.O. Ng, and Y.M. Dennis Lo -- Molecular analysis of mitochondrial DNA point mutations by polymerase chain reaction / Lee-Jun C. Wong, Bryan R. Cobb, and Tian-Jian Chen -- Novel applications of polymerase chain reaction to urinary nucleic acid analysis / Anatoly V. Lichtenstein ... [et al.] -- Detection and quantitation of circulating plasmodium falciparum DNA by polymerase chain reaction / Shira Gal and James S. Wainscoat -- Molecular diagnosis of severe acute respiratory syndrome / Enders K.O. Ng and Y.M. Dennis Lo -- Genomic sequencing of the severe acute respiratory syndrome-coronavirus / Stephen S.C. Chim, Rossa W.K. Chiu, and Y.M. Dennis Lo.Introduction to the polymerase chain reaction / Y.M. Dennis Lo and K.C. Allen Chan -- Setting up a polymerase chain reaction laboratory / Y.M. Dennis Lo and K.C. Allen Chan -- Real-time polymerase chain reaction and melting curve analysis / Robert J. Pryor and Carl T. Wittwer -- Qualitative and quantitative polymerase chain reaction-based methods for DNA methylation analyses / Ivy H.N. Wong -- In-cell polymerase chain reaction: strategy and diagnostic applications / T. Vauvert Hviid -- Qualitative and quantitative DNA and RNA analysis by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry / Chunming Ding -- Analysis of polymerase chain reaction products by denaturing high-performance liquid chromatography / Ching-Wan Lam -- Use of real-time polymerase chain reaction for the detection of fetal aneuploidies / Bernhard Zimmermann ... [et al.] -- Noninvasive prenatal diagnosis by analysis of fetal DNA in maternal plasma / Rossa W. K. Chiu and Y. M. Dennis Lo --

1. Sudden Unexplained Death -- Sudden Unexplained Death in the Community / Sumeet S. Chugh, Carmen Teodorescu, Audrey Evanado and Kyndaron Reinier -- Sudden Infant Death Syndrome: Gene-Environment Interactions / Carl E. Hunt and Fern R. Hauck -- 2. Arrhythmias and Sudden Cardiac Death. The Initial Investigation -- Unexplained Syncope / Carlos A. Morillo and Víctor Expósito-García -- Arrhythmias and Sudden Cardiac Death in Adult Congenital Heart Disease / Paul Khairy -- Endurance Sport Practice and Arrhythmias / Eduard Guasch and Lluís Mont -- Electrocardiograms Not to Miss / Andres Perez-Riera -- Sudden Cardiac Death in Forensic Pathology / Antonio Oliva and Vincenzo L. Pascali -- 3. Cardiac Genetic Syndromes -- Genetic Studies / Marie-Pierre Dubé and John Rioux -- The Long QT Syndrome / Ramon Brugada and Oscar Campuzano -- Brugada Syndrome / Begoña Benito, Ramon Brugada, Josep Brugada and Pedro Brugada -- Short QT Syndrome / Christian Wolpert, Christian Veltmann, Rainer Schimpf and Martin Borggrefe -- Catecholaminergic Polymorphic Ventricular Tachycardia / M. Juhani Junttila, Olli Anttonen and Heikki V. Huikuri -- Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia / Michela Bevilacqua, Federico Migliore, Cristina Basso, Gaetano Thiene and Domenico Corrado -- Atrial Fibrillation / Oscar Campuzano and Ramon Brugada -- Dilated Cardiomyopathy / Michelle S. C. Khoo, Luisa Mestroni and Matthew R. G. Taylor -- Hypertrophic Cardiomyopathy / A. J. Marian -- Genetic Lipoprotein Disorders and Cardiovascular Disease / Khalid Alwaili, Khalid Alrasadi, Zari Dastani, Iulia Iatan and Zuhier Awan, et al. -- A Systematic Approach to Marfan Syndrome and Hereditary Forms of Aortic Dilatation and Dissection / Peter N. Robinson and Yskert von Kodolitsch -- Inherited Metabolic Diseases: Emphasis on Myocardial Disease and Arrhythmogenesis / Eduardo Back Sternick -- Clinical Genetics in Congenital Heart Disease / Georgia Sarquella Brugada and Gregor Andelfinger -- 4. Polygenic Cardiovascular Genetics -- Pharmacogenomics / Simon de Denus, Michaels Phillips and Jean-Claude Tardif -- Polygenic Studies in the Risk of Arrhythmias / Moritz F. Sinner and Stefan Kääb -- The Genetic Challenge of Coronary Artery Disease / Robert Roberts, George Wells and Li Chen -- 5. Ethical, Legal and Social Implications -- Psychological Implications of Genetic Investigations / April Manuel, Fern Brunger and Kathy Hodgkinson -- Participation in Recreational Sports for Young Patients with Genetic Cardiovascular Diseases / Barry J. Maron -- Genetic Counseling in Cardiovascular Conditions / Laura Robb.

Introduction to Electroporation -- Electroporation and Cellular Physiology -- The Cell in the Electric Field -- Understanding Electric Fields for Clinical Use -- Generators and Applicators: Equipment for Electroporation -- Cell Electropermeabilization and Cellular Uptake of Small Molecules: The Electrochemotherapy Concept -- Vascular-Disrupting Action of Electrochemotherapy: Mode of Action and Therapeutic Implications -- Electrochemotherapy of Small Tumors; The Experience from the ESOPE (European Standard Operating Procedures for Electrochemotherapy) Group -- Electrochemotherapy for Larger Malignant Tumors -- Cell Electroporation in Bone Tissue -- Drug and Gene Electrotransfer to the Brain -- Minimally Invasive Intraluminal Tumor Ablation -- Electrotransfer of Plasmid DNA -- Gene Electrotransfer to Tumor -- Gene Electrotransfer to Lung -- Gene Electrotransfer to Muscle Tissue: Moving into Clinical Use -- Gene Electrotransfer to Skin -- Electroporation-Mediated DNA Vaccination -- Irreversible Electroporation (IRE) on Liver Tumor Ablation: A Summary of Preclinical Translational Research -- Translational Research on Irreversible Electroporation: VX2 Rabbit Head and Neck -- Clinical Research on Irreversible Electroporation of the Liver.

Section I: The scientific basis -- Clinical autonomic disorders: classification and clinical evaluation / Phillip A. Low, Paola Sandroni, and Eduardo E. Benarroch -- Central autonomic network / Eduardo E. Benarroch -- Peripheral autonomic system: anatomy, biochemistry, and physiology / Eduardo E. Benarroch -- Cardiovascular and respiratory reflexes: physiology and pharmacology / Roger A. L. Dampney -- Maintenance of postural normotension in humans / Wouter Wieling and Johannes J. Van Lieshout -- Autonomic regulation of temperature and sweating / Eduardo E. Benarroch, Phillip A. Low, and Robert D. Fealey -- Central nervous system control of micturition / Gert Holstege and Han Collewijn -- Autonomic control of gastrointestinal function / David R. Linden and Gianrico Farrugia -- Neural control of blood vessels / Eduardo E. Benarroch and Axel Lipp --Section II: Evaluation and management of autonomic disorders --Part A. Laboratory evaluation -- Clinical evaluation of the patient with an autonomic disorder / William P. Cheshire, Jr., and Nancy L. Kuntz -- Laboratory evaluation of autonomic failure / Phillip A. Low and David M. Sletten -- Aging and autonomic function / Lewis A. Lipsitz and Vera Novak -- Quality of life in persons with autonomic disorders / Lisa M. Benrud-Larson and Anette Schrag -- Noninvasive evaluation of heart rate: time and frequency domains / Roy L. Freeman -- Transcranial doppler evaluation in autonomic disorders / Wolfgang Singer, Phillip A. Low, and Ronald Schondorf -- Microneurographic evaluation of sympathetic neural function and dysfunction / Nisha Charkoudian and B. Gunnar Wallin -- Autonomic evaluation in the electromyography laboratory / William J. Litchy -- Thermoregulatory sweat test / Robert D. Fealey --Part B. Central disorders -- Innervation of nonglabrous skin / William R. Kennedy and Gwen Wendelschafer-Crabb -- Neurochemical indices of autonomic function / David S. Goldstein -- Degenerative autonomic disorders (autonomic synucleinopathies) / Horacio C. Kaufmann and Eduardo E. Benarroch -- Clinical pharmacology of autonomic failure / Italo Biaggioni --Sleep and degenerative autonomic disorders / Pietro Cortelli and Federica Provini -- Imaging studies in chronic autonomic disorders / David S. Goldstein -- Autonomic manifestations of epilepsy and stroke / Roy L. Freeman and Eduardo E. Benarroch --Part C. Peripheral disorders -- Autonomic complications of multiple sclerosis / Judith M. Spies -- Autonomic disorders associated with spinal cord injury / Andrei V. Krassioukov -- The neuropathology of autonomic neuropathies / Phillip A. Low ... [et al.] -- The autonomic neuropathies / Phillip A. Low and Paola Sandroni -- Diabetic autonomic neuropathy / Phillip A. Low and Max J. Hilz -- Autoimmune and paraneoplastic autonomic neuropathies / Steven Vernino -- Autonomic complications of AIDS and other infectious disorders / Dominic C. Chow, Andrew Grandinetti, and Robert H. Wood -- Hereditary sensory and autonomic neuropathies and miscellaneous inherited neuropathies with autonomic involvement / Michelle L. Mauermann and Christopher J. Klein --Part D. Disorders of orthostatic tolerance -- Familial dysautonomia / Felicia B. Axelrod -- Syncope: approach to management / Wouter Wieling and Win-Kuang Shen -- Postural tachycardia syndrome / Phillip A. Low ... [et al.] -- Genetic causes of orthostatic intolerance / Emily M. Garland and David Robertson -- Management of neurogenic orthostatic hypotension / Phillip A. Low and Robert D. Fealey --Part E. Disorders of thermoregulation, skin blood flow, and cranial autonomic control -- Hyperhidrosis and anhidrosis / Robert D. Fealey, John L. D. Atkinson, and William P. Cheshire, Jr. -- Facial flushing and trigeminal autonomic cephalalgias / Michael F. Cutrer and Drahomira Sencakova -- Disorders of the pupils and lacrimal glands / Paul W. Brazis and Andrew G. Lee -- Migraine and the autonomic nervous system / Pasquale Montagna and Pietro Cortelli --Part F. Disorders of pain, bladder, sexual, and gastrointestinal function -- Complex regional pain syndrome and erythromelalgia / Paola Sandroni, David P. Martin, and Mark D. P. Davis -- The diagnosis and treatment of patients with neurologic dysfunction of the urinary bladder / Van Anh T. Ginger and Claire C. Yang -- Female and male sexual dysfunction / Max J. Hilz -- Gastrointestinal motility / Michael Camilleri --Part G. Other disorders -- Syndromes of autonomic hyperactivity / Alejandro A. Rabinstein, Nestor A. Wainsztein, and Eduardo E. Benarroch -- Episodic adrenergic syndromes: pheochromocytoma, pseudopheochromocytoma, mastocytosis, and carcinoid tumors / Graeme Eisenhofer and Italo Biaggioni.

Introducing clinical biochemistry -- Core biochemistry -- Endocrinology -- Specialized investigations.

Part 1. Clinical Bioethics: Comparing Theoretical Models -- Clinical Bioethics in a Post Modern Age / David Thomasma, p. 3-20 -- The "Telos" of Medicine and the Good of the Patient / Edmund Pellegrino, p. 21-32 -- The Foundation of Medical Ethics in the Democratic Evolution of Modern Society / Diego Gracia, p. 33-40 -- A Communitarian Approach to Clinical Bioethics / Henk Have, p. 41-51 -- A Hermeneutical Approach to Clinical Bioethics / Bruno Cadoré, p. 53-59 -- A Deliberative Approach to Clinical Bioethics / Michael Parker, p. 61-71 -- Part 2. Toward Clinical Bioethics Integrating "Internalmorality" and "External Morality" -- "A Helping and Caring Profession": Medicine as a Normative Practice / Henk Ten Have, p. 75-97 -- Part 2.1. The Goals of Medicine in Relation to the Subjectivisation of Health and Rationalisation of Health Care Institutions -- Medicine as a Practice and the Ethics of Illness / Roberto Mordacci, p. 101-113 -- The Right to Choose One's Health / Paolo Zatti, p. 115-129 -- The Tension Between Ethics and Evidence-Based Medicine / Paolo Vineis, p. 131-137 -- Maintaining Integrity in Times of Scarse Resources / H. Jochemsen, J. Hoogland and J. Polder, p. 139-152 -- Part 2.2. Bioethical Judgment: Epistemological Statute and Institutional Context -- Interpreting Clinical Judgment: Epistemological Notes on the Praxis of Medicine / Roberto Dell'oro, p. 155-167 -- For an Ethical Function in Hospitals / Pierre Boitte, p. 169-180 -- The Ethical Function in the Health Care Institutions: Clinical Ethics Committees / Corrado Viafora, p. 181-192.

In silico gene discovery / Bing Yu -- Whole genome-wide association study using Affymetrix SNP chip : a two-stage sequential selection method to identify genes that increase the risk of developing complex diseases / Howard H. Yang ... [et al.] -- Utilizing HapMap and tagging SNPs / Christopher A. Haiman and Daniel O. Stram -- Measuring the effects of genes and environment on complex traits / Jennifer H. Barrett -- Microarrays-planning your experiment / Jean Yee Hwa Yang -- Clinical uses of microarrays in cancer research / Carl Virtanen and James Woodgett -- Microarrays-analysis of signaling pathways / Anassuya Ramachandran ... [et al.] -- Microarrays-identifying molecular portraits for prostate tumors with different Gleason patterns / Alexandre Mendes, Rodney J. Scott, and Pablo Moscato -- Microarrays for the study of viral gene expression during human cytomegalovirus latent infection / Barry Slobedman and Allen K.L. Cheung -- Computer-assisted reading of DNA sequences / Huong Le ... [et al.] -- Evaluating DNA sequence variants of unknown biological significance / Scott A. Grist, Andrew Dubowsky, and Graeme Suthers -- Developing a DNA variant database / David C.Y. Fung -- Protein comparative sequence analysis and computer modeling / Brett D. Hambly, Cecily E. Oakley, and Piotr G. Fajer -- Identification and characterization of microbial proteins using peptide mass fingerprinting strategies / Jonathan W. Arthur -- Statistical analysis of image data provided by two-dimensional gel electrophoresis for discovery proteomics / Ben Crossett ... [et al.] -- Online resources for the molecular contextualization of disease / Chi N.I. Pang and Marc R. Wilkins -- Web-based resources for clinical bioinformatics / Anthony M. Joshua and Paul C. Boutros -- Developing decision support systems in clinical bioinformatics / Vitali Sintchenko and Enrico Coiera -- eConsulting / Siaw-Teng Liaw and Peter Schattner.

My Aunt Minnie -- Screening -- Diagnostic breast imaging -- Management.

I. Background. Development and structure of the cardiac conduction system / Parvin Dorostkar -- Physiology of the cardiac conduction system / Peter S. Fischbach -- Clinical electrophysiology of the cardiac conduction system / Macdonald Dick II ... [et al.] -- II. Clinical electrophysiology in infants and children. Atrioventricular reentry tachycardia / Ian H. Law -- Atrioventricular nodal reentrant tachycardia / David J. Bradley -- Persistent junctional reciprocating tachycardia / Parvin C. Dorostkar -- Sinoatrial reentrant tachycardia / Macdonald Dick II -- Intra-atrial reentrant tachycardia - atrial flutter / Ian H. Law and Macdonald Dick II -- Atrial fibrillation / Peter S. Fischbach -- Atrial ectopic tachycardias/atrial automatic tachycardia / Burt Bromberg -- Multifocal atrial tachycardia / David J. Bradley -- Ventricular tachycardia / Craig Byrum --Sick Sinus syndrome / William A. Scott -- First- and second-degree atrioventricular block / William A. Scott -- Complete heart block - third-degree heart block / Mohamad Al-Ahdab -- Syncope / Margaret Strieper, Robert M. Campbell, William A. Scott -- Cardiac pacemakers and implantable cardioverter-defibrillators / Gerald S. Serwer and Ian H. Law -- Genetic disorders of the cardiac impulse / Mark W.W. Russell and Stephanie Wechsler -- Fetal arrhythmia / Elizabeth V. Saarel and Carlen Gomez -- Sudden cardiac death in the young / Christopher B. Stefanelli -- Pharmacology of antiarrhythmic agents / Peter S. Fischbach -- Transcatheter ablation of cardiac arrhythmias in the young / Macdonald Dick II, Peter S. Fischbach and Ian H. Law -- Nursing management of arrhythmias in the young / Sarah Leroy.

Electrophysiologic investigation: technical aspects -- Electrophysiologic investigation: general concepts -- Sinus node function -- Atrioventricular conduction -- Intraventricular conduction disturbances -- Miscellaneous phenomena related to atrioventricular conduction -- Ectopic rhythms and premature depolarizations -- Supraventricular tachycardias -- Atrial flutter and fibrillation -- Preexcitation syndromes -- Recurrent ventricular tachycardia -- Evaluation of antiarrhythmic agents -- Evaluation of electrical therapy for arrhythmias -- Catheter and surgical ablation in the therapy of arrhythmias.

Cardiac MRI physics / S. Dymarkowski and H. Bosmans -- Contrast agents for cardiac MRI / Y. Ni and S. Dymarkowski -- Practical setup / S. Dymarkowski and P. Hamaekers -- Cardiac anatomy / J. Bogaert and A. M. Taylor -- Cardiovascular MR imaging planes and segmentation / A. M. Taylor and J. Bogaert -- Cardiac function / J. Bogaert -- Myocardial perfusion / Nidal Al-Saadi, and J. Bogaert -- Ischemic heart disease / S. Dymarkowski, J. Bogaert, and Y. Ni -- Nonischemic myocardial disease / J. Bogaert and A. M. Taylor -- Heart failure, pulmonary hypertension, and heart transplantation / S. Dymarkowski and J. Bogaert -- Pericardial disease / J. Bogaert, A. M. Taylor, and S. Dymarkowski -- Cardiac masses / J. Bogaert and S. Dymarkowski -- Valvular heart disease / A. M. Taylor and J. Bogaert -- Coronary artery disease / J. Bogaert, S. Dymarkowski, and A. M. Taylor -- Congenital heart disease / V. Mutharangu ... [et al.] -- Imaging of great vessels / S. R. Hegde ... [et al.] -- MR-guided cardiac catheterization / RR. Razavi ... [et al.] -- General conclusions / J. Bogaert, S. Dymarkowski, and A. M. Taylor.

Introduction to molecular genetics -- Clinical genetics -- Hypertrophic cardiomyopathy -- Familial dilated cardiomyopathy -- Arrhythmogenic right ventricular dysplasia/cardiomyopathy from desmosome to disease -- Noncompaction cardiomyopathy -- Mitochondrial cardiomyopathy -- Restrictive cardiomyopathy -- Congenital long QT-syndrome -- The Brugada syndrome -- Short QT syndrome -- Catecholaminergic polymorphic ventricular tachycardia -- A molecular genetic perspective on atrial fibrillation -- Idiopathic ventricular fibrillation -- The genetics of mitral valve prolapse -- Atrioventricular (AV) reentry tachycardia -- Hereditary cardiac conduction diseases -- Connective tissue disorders and smooth muscle disorders in cardiology -- Genetics of congenital heart defects -- Genetic disorders of the lipoprotein metabolism: diagnosis and management -- Novel insights into genetics of arterial thrombosis -- The pharmacogenetics of atherosclerosis -- Genetics of (premature) coronary artery disease -- Heredity neuromuscular diseases and cardiac involvement -- Sudden cardiac death in the young: epidemiology and cardiogenetic evaluation of victims and their relatives -- The outpatient clinics for cardiogenetics -- Abdominal aortic aneurysm -- Future of cardiogenetics.

Physics of diagnostic ultrasound : creating the image / Reuter, K.L., Bogdan, A. -- Thoracic ultrasound overview / Islam, S., Tonn, H. -- Transthoracic ultrasound for chest wall, pleura, and the peripheral lung / Koegelenberg, C.F.N., Diacon, A.H., Bolliger, C.T. -- Ultrasound of the neck / Kreuter, M. ... [et al.] -- Diagnosis of pulmonary embolism and pneumonia using transthoracic sonography / Reissig, A., Kroegel, C. -- The mediastinum / Herth, F.J.F. -- Critical care echocardiography / Mayo, P.H. -- Use of ultrasound for central venous access / Garibaldi, B., Feller-Kopman, D. -- Ultrasound evaluation of the lung / Pellecchia, C., Mayo, P.H. -- Pleural ultrasonography in the intensive care unit / Wang, J.S., Doelken, P. -- Abdominal ultrasonography as related to problems of the chest / Beckh, S., Kirchpfening, K. -- Use of ultrasonography for the diagnosis of venous thromboembolic disease / Kaplan, A.E., Kory, P. -- Principles and practice of endoscopic ultrasound / Nishina, K. ... [et al.] -- Short history of the development of endobronchial ultrasound : a story of success / Becker, H.D. --State-of-the-art equipment and procedures / Kurimoto, N., Osada, H., Miyazawa, T. -- Convex probe endobronchial ultrasound / Yasufuku, K., Nakajima, T. -- Endobronchial ultrasound for staging of lung cancer / Herth, F.J.F. -- Endobronchial ultrasound for peripheral pulmonary lesions / Kurimoto, N., Osada, H., Miyazawa, T. -- Esophageal ultrasound / Annema, J.T., Rabe, K.F. -- Competing technologies : ultrasound, navigational bronchoscopy, optical coherence tomography, etc. : who will win out? / Lee, P., Beamis, J.F. -- Ultrasound and medical thoracoscopy / Michaud, G. -- Endobronchial ultrasound for difficult airway problems / Shirakawa, T. ... [et al.] -- Ultrasound guidance for endoscopic treatment of pulmonary malignancies / Eberhardt, R., Bugalho, A. -- Ultrasound-guided drainage procedures and biopsies / Wang, J.S., Doelken, P.

Overview of clinical decision support systems / Eta S. Berner and Tonya J. La Londe -- Mathematical foundations of decision support systems / S. Andrew Spooner -- Data mining and clinical decision support systems / J. Michael Hardin and David C. Chhieng -- Design and implementation issues / Jerome H. Carter -- Diagnostic decision support systems / Randolph A. Miller and Antoine Geissbuhler -- Ethical and legal issues in decision support / Kenneth W. Goodman -- Clinical trials of information interventions / E. Andrew Balas and Suzanne Austin Boren -- Clinical decision support at Intermountain Healthcare / Peter J. Haug ... [et al.] -- Clinical decision support within the Regenstrief medical record system / Burke W. Mamlin ... [et al.] -- Decision support during inpatient care provider order entry : the Vanderbilt experience / Randolph A. Miller ... [et al.] -- Decision support for patients / Holly B. Jimison, Paul P. Sher, Jennifer J.B. Jimison.

Overview of clinical decision support systems -- Mathematical foundations of decision support -- Data mining and clinical decision support systems -- Design and implementation issues -- Diagnostic decision support systems -- Ethical and legal issues in decision support -- Clinical trials of information interventions -- Clinical decision support at Intermountain Healthcare -- Clinical decision support within the Regenstrief medical record system -- Decision support during inpatient care provider order entry: the Vanderbilt experience -- Decision support for patients.

Preface -- Fluid and Electrolyte Disorders -- Acid-Base Disturbances -- Disorders of Divalent Ion Metabolism -- Nephrolithiasis -- Hypertension -- Acute Renal Failure -- Hereditary Nephritis and Genetic Disorders -- Glomerular, Vascular and Tubulo-Interstitial Diseases -- Chronic Kidney Disease -- Renal Osteodystrophy -- End-Stage Renal Disease and Dialysis -- Transplantation -- Index.

1.Eyelids --2.Orbit --3.Conjunctiva --4.Episclera and sclera --5.Dry eye --6.Cornea --7.Lens --8. Glaucoma --9.Intraocular tumours --10.Uveitis --11.Retinal detachment --12.Retinal vascular disease --13.Acquired macular disorders --14.Fundus dystrophies --15.Congenital anomalies of the posterior segment --16.Neuro-ophthalmology --17.Strabismus --18.Trauma.

Physics : principles, practice, and artefacts / W. Norman McDicken and Peter R. Hoskins -- Haemodynamics and blood flow / Peter R. Hoskins, W. Norman McDicken, and Paul L. Allan -- The carotid and vertebral arteries ; Transcranial colour Doppler / Paul L. Allan and Karen Gallagher -- The peripheral arteries / Paul L. Allan and Karen Gallagher -- The peripheral veins / Paul L. Allan and Karen Gallagher -- The aorta and inferior vena cava / Paul L. Allan -- Doppler ultrasound of the liver / Myron A. Pozniak -- The kidney / Paul A. Dubbins -- Doppler ultrasound evaluation of transplantation / Myron A. Pozniak -- Doppler imaging of the prostate / Fred T. Lee, Jr. -- Doppler imaging of the penis / Myron A. Pozniak and Fred T. Lee, Jr. -- Doppler imaging of the scrotum / Myron A. Pozniak -- Doppler ultrasound of the female pelvis / Paul A. Dubbins -- Clinical applications of Doppler ultrasound in obstetrics / Imogen Montague and Paul A. Dubbins -- Microbubble ultrasound contrast agents / Jonathan D. Berry and Paul S. Sidhu -- Appendix: System controls and their uses.

Introductory principles -- Basic ECG waves -- ECG leads -- The normal ECG -- Electrical axis and axis deviation -- Atrial and ventricular enlargement -- Ventricular conduction disturbances (Bundle branch blocks) -- Myocardial ischemia and infarction, section I (ST segment elevation ischemia and Q wave infarct patterns ) -- Myocardial ischemia and infarction, section II (ST segment depression ischemia and non-Q wave infarct patterns ) -- Drug effects, electrolyte abnormalities and metabolic factors -- Pericardial, myocardial and pulmonary syndromes -- Wolff-Parkinson-White preexcitation patterns -- Sinus rhythms -- Supraventricular arrhythmias, section I (Premature atrial and AV junctional beats, paroxysmal supraventricular tachycardias, and AV junctional rhythms) -- Supraventricular arrhythmias, section II (Atrial flutter and atrial fibrillation) -- Ventricular arrhythmias -- Atrioventricular (AV) heart block -- Digitalis toxicity -- Cardiac arrest and sudden cardiac death -- Bradycardias and tachycardias: review and differential diagnosis -- Pacemakers and implantable cardioverter-defibrillators: a brief introduction -- How to interpret an ECG -- Limitations and uses of the ECG -- ECG differential diagnoses: instant reviews.

On framing the research question and choosing the appropriate research design / Patrick Parfrey and Pietro Ravani -- Longitudinal studies and determination of risk / Sean W. Murphy -- Modeling longitudinal data, I : principles of multivariate analysis / Pietro Ravani, Brendan Barrett, and Patrick Parfrey -- Modeling longitudinal data, II : standard regression models and extensions / Pietro Ravani, Brendan Barrett, and Patrick Parfrey -- The design of randomized controlled trials / Bryan M. Curtis, Brendan J. Barrett, and Patrick Parfrey -- Analysis of randomized controlled clinical trials / Robert N. Foley -- Evaluation of diagnostic tests / John M. Fardy -- Biomarkers and surrogates in clinical studies / Claudio Rigatto and Brendan J. Barrett -- Measurement and analysis of patient-reported outcomes / Klemens B. Meyer and Kimberly A. Clayton -- Bias in clinical studies of genetic diseases / Susan Stuckless and Patrick Parfrey -- Genetic epidemiology of complex phenotypes / Lynette Peddle and Proton Rahman.Qualitative research in clinical epidemiology / Deborah M. Gregory and Christine Y. Way -- Primer on systematic review and meta-analysis / Marcello Tonelli, Dan Hackman, and Amit X. Garg -- The role of health economics within clinical research / Braden J. Manns -- Development and limitations of clinical practice guidelines / Bruce Culleton -- Basics of health technology assessment / Daria O'Reilly, Kaitryn Campbell, and Ron Goeree -- Research ethics for clinical researchers / John D. Harnett and Richard Neumann -- Budgeting, funding, and managing clinical research projects / Elizabeth Hatfield, Elizabeth Dicks, and Patrick Parfrey.

Forming research questions -- Conducting systematic reviews -- Finding information about the burden of disease -- An introduction to performing therapeutic trials -- The tactics of performing therapeutic trials -- The principles behind the tactics of performing therapeutic trials -- Testing quality improvement interventions -- Evaluating diagnostic tests -- Determining prognosis and creating clinical decision rules -- Assessing claims of causation -- Generating outcome measurements, especially for quality of life -- Becoming a successful clinician-investigator -- Preparing a research protocol to improve its chances for success -- Online data collection -- Analyzing data -- Preparing reports for publication and responding to reviewers' comments -- Dealing with the media.

Clinical epidemiology: what it is and how it is used -- Diagnostic and screening tests: measuring their ability to predict adverse outcomes of illness -- Diagnostic and screening tests: measuring their role in improving the outcome of illness -- Therapeutic efficacy: randomized controlled trials -- Therapeutic efficacy: nonrandomized studies -- Therapeutic safety -- Natural history of illness -- Summarizing evidence: systematic reviews and meta-analysis / Peter Cummings and Noel S. Weiss.

Introduction -- Abnormality -- Diagnosis -- Frequency -- Risk, looking forward -- Risk, looking backward -- Prognosis -- Treatment -- Prevention -- Chance -- Cause -- Systematic reviews -- Knowledge management.

Indicated and nonindicated interventions -- Orders not to resuscitate (DNR) -- Legal implications of forgoing treatment -- Determination of death -- Informed consent -- Decisional capacity -- Beliefs due to religious and cultural diversity -- Truthful communication -- Competent refusal of treatment -- Advance planning -- Decision making for the mentally incapacitated patient -- The limits of patient preferences -- Failure to cooperate with medical recommendations -- Alternative medicine -- Enhancing quality of life -- Compromised quality of life and life-sustaining interventions -- Euthanasia and assisted suicide -- Care of the dying patient -- Suicide -- Role of interested parties -- Confidentiality of medical information -- The economics of clinical care -- Allocation of scarce health resources -- Influence of religion on clinical decisions -- The role of the law in clinical decisions -- Clinical research -- Clinical teaching -- Occupational medicine -- Public health -- Ethics committees -- Ethics consultation.

Medical Indications -- Patient Preferences -- Quality of Life -- Contextual Features.

Consultation, medical history, and record-taking / Ian Watt -- The general examination / Owen Epstein -- Skin, hair, and nails / Owen Epstein -- Ear, nose, and throat / Graham A. W. Hornett -- The respiratory system / John Cookson -- The heart and cardiovascular system / Roby Rakhit -- The abdomen / Owen Epstein -- Female breasts and genitalia / Owen Epstein -- The male genitalia / Owen Epstein -- Bone, joints, and muscle / G. David Perkin -- The nervous system / G. David Perkin -- Infants and children / Andrew Robins.

Introduction-- Facial Analysis: What, Why, When, and How, p. 1-5 -- Approaching the Patient for Direct and Photographic Facial Analysis., p. 7-12 -- Lighting Techniques for Clinical Facial Photography, p. 15-21-- Views of Clinical Facial Photography, p. 23-32 -- The "Facial Points of Interest", p. 35-40 -- Basic Facial Analysis, p. 43-56 -- Forehead, Eyebows, and Eyes, p. 59-69 -- Nasal Analysis, p. 71-94 -- Lips, Teeth, Chin, and Smile Analysis, p. 97-112 -- Dentofacial Deformities, p. 115-142 -- The Aging Face, p. 145-160 -- Continuing Facial Analysis, p. 163-166 -- Exercises in Clinical Photography and Analysis, p. 167-169 -- Suggested Reading, p. 171-174 -- Surround Yourself with Experts (and Other Important Advice for a Constructive and Creative Surgical Practice), p. 175-178.

Approaching the Patient for Direct and Photographic Facial Analysis --Lighting Techniques for Clinical Facial Photography --Views of Clinical Facial Photography --The "Facial Points of Interest" --Basic Facial Analysis --Forehead, Eyebrows, and Eyes --Nasal Analysis --Lips, Teeth, Chin, and Smile Analysis --Dentofacial Deformities --The Aging Face --Continuing Facial Analysis Utilizing Four Images by Man Ray --Continuing Facial Analysis --Aesthetic Facial Surgery: First Consultation Notes, Essential Medical History, and Clinical Diary --Exercises in Clinical Photography and Analysis --Suggested Reading --Surround Yourself with Experts (and Other Important Advice for a Constructive and Creative Surgical Practice) --Beauty Is Composite By Edoardo Lombardi Vallauri.

The history and development of clinical forensic medicine worldwide / Jason Payne-James -- Fundamental principles / Roy N. Palmer -- Sexual assault examination / Deborah Rogers and Mary Newton -- Injury assessment, documentation, and interpretation / Jason Payne-James, Jack Crane, and Judith A. Hinchliffe -- Nonaccidental injury in children / Amanda Thomas -- Crowd control agents / Kari Blaho-Owens -- Medical issues relevant to restraint / Nicholas Page -- Care of detainees / Guy Norfolk and Margaret M. Stark -- Infectious diseases / Felicity Nicholson -- Substance misuse / Margaret M. Stark and Guy Norfolk -- Deaths in custody / Richard Shepherd -- Traffic medicine / Ian F. Wall and Steven B. Karch.

Perfusion and function in the normal and abnormal heart -- Physics and technical aspects of gated myocardial perfusion SPECT -- Stress testing and imaging protocols -- Quantification of myocardial perfusion -- Quantification of ventricular function -- Interpretation and reporting of gated myocardial perfusion SPECT -- Artifacts caused by and clarified by gated myocardial perfusion SPECT -- Clinical value of combined perfusion and function imaging in the diagnosis, prognosis, and management of patients with suspected or known coronary artery disease -- Assessment of myocardial perfusion and left ventricular function in acute coronary syndromes: implications for gated SPECT imaging -- Clinical value of assessment of perfusion and function for the evaluation of myocardial viability in patients with ischemic left ventricular dysfunction -- Quantitative gated blood pool SPECT -- Gated positron emission tomography for the assessment of myocardial perfusion and function -- Comparison of function, viability, and perfusion assessed by myocardial perfusion SPECT and CMR -- Complementary roles of cardiac CT and gated myocardial perfusion SPECT or PET in patients with known or suspected CAD.

Human genetic disease -- Basic and molecular biology: an introduction -- Human variation and its applications -- Gene action and patterns of inheritance -- Cytogenetic chromosome disorders -- Inherited biochemical disorders -- Birth defects and congenital anomalies -- Impact of genetic diseases on the family unit -- Assessment of genetic disorders -- Genetic counseling -- Genetic testing and screening -- Prenatal detection and diagnosis -- The vulnerable fetus -- Reproductive and genetic effects of environmental chemicals and radiation -- Therapeutic modalities -- Genetics and the common diseases -- Twins, twin studies and multiple births -- Drug therapy and genetics--pharmacogenetics and pharmacogenomics -- Genetics and the immune system -- Mental retardation -- Aging, longevity and Alzheimer Disease -- Emphysema, liver disease and alpha-1-antitrypsin deficiency -- Cancer -- Diabetes mellitus -- Mental illness and behavior -- Heart disease -- Genes and future generations.

Getting the office ready for the patient / Robert F. Kushner -- Steps for the medical evaluation of the obese patient / Nawfal W. Istfan and Wendy A. Anderson -- Motivational interviewing and health behavior change counseling / Gary S. Rose, Judy C.C. Phillips, and Garry Welch -- Dietary therapy / Diana Cullum-Dugan and Cheryl Jesuit -- Exercise therapy for the overweight adult / John M. Jakicic, Amy D. Otto, and Kristen Polzien -- Pharmacologic therapy for obesity and overweight in adults and adolescents / Marie Thearle and Louis J. Aronne -- Surgical treatment of obesity / Alene J. Wright, Ranjan Sudan, and R. Armour Forse -- Gastrointestinal complications of bariatric surgery / Christopher S. Huang and Francis A. Farraye -- Follow-up strategies for the treatment of obesity in primary care settings / Valerie H. Myers and Donna H. Ryan --Maintenance: the ultimate goal / Rena R.Wing, Angela Marinilli Pinto, and Heather Niemeier -- A clinical guide to pediatric ambulatory weight management / Carine M. Lenders, Alan F. Meyers, and Holly Oh -- Behavioral health considerations for the management of pediatric obesity in primary care / Shaheen U. Lakhani ... [et al.] -- The community as a resource to support positive nutrition and physical activity behaviors in youth / Vivien Morris and Gita Rao.

General aspects of epilepsies -- Epileptic seizures and their classification -- Status epilepticus -- Imitators of epileptic seizures -- Epileptic syndromes and their classification -- EEG and brain imaging -- Principles of therapy in the epilepsies -- Neonatal epileptic seizures and neonatal epileptic syndromes -- Idiopathic epileptic seizures and syndromes in infancy -- Epileptic encephalopathies in infancy and early childhood -- Severe neocortical epileptic syndromes in infancy and childhood -- Benign childhood focal seizures and related epileptic syndromes -- Idiopathic generalised epilepsies -- Familial (autosomal dominant) focal epilepsies -- Symptomatic and cryptogenic (probably symptomatic) focal epilepsies -- Reflex seizures and related epileptic syndromes -- Diseases frequently associated with epileptic seizures -- Pharmacopoeia.

Laboratory diagnosis of pediatric infectious disease -- Osteomyelitis and septic arthritis -- Congenital infections -- Congenital immunodeficiencies -- Hepatitis -- Otitis media and sinusitis -- Outpatient evaluation of fever -- Periorbital and orbital cellulitis -- Cervical adenitis -- Urinary tract infections -- Meningitis -- Pediatric tuberculosis -- Community-acquired pneumonia -- Salmonella gastroenteritis -- Catheter infection -- Infection in unusual spaces -- Fever and neurtropenia -- Fever of unknown origin -- Infection in solid organ transplant recipients -- Prophylaxis.

Introduction: medical management of obesity -- Epidemiology of childhood obesity -- Pathophysiology of obesity -- Obesity in the context of child and adolescent development -- Evaluation of the obese child -- Respiratory complications -- Cardiovascular complications -- Insulin resistance, the metabolic syndrome, and type 2 diabetes -- Orthopedic complications -- Gastrointestinal complications -- Renal complications -- Neurologic complications -- Mental health issues -- Specific genetic causes of obesity -- Acute obesity-related emergencies -- Practice management strategies for obesity.

Molecular biology for clinicians -- Hormone biosynthesis, metabolism, and mechanism of action -- The ovary-embryology and development -- The uterus -- Neuroendocrinology -- Regulation of the menstrual cycle -- Sperm and egg transport, fertilization, and implantation -- The endocrinology of pregnancy -- Normal and abnormal sexual development -- Normal and abnormal growth and pubertal development -- Amenorrhea -- Chronic anovulation and the polycystic ovary syndrome -- Hirsutism -- Menstrual disorders -- Abnormal uterine bleeding -- The breast -- Menopause and the perimenopausal transition -- Postmenopausal hormone therapy -- Obesity -- Reproduction and the thyroid -- Family planning, sterilization, and abortion -- Oral contraception -- Vaginal and transdermal estrogen-progestin contraception -- Long-acting methods of contraception -- Intrauterine contraception -- Barrier methods of contraception and withdrawal -- Female infertility -- Recurrent early pregnancy loss -- Endometriosis -- Male infertility -- Induction of ovulation -- Assisted reproductive technologies -- Ectopic pregnancy -- Appendix-I: Interpreting epidemiologic reports -- Appendix-II: Selected laboratory values and the international system of units (SI Units).

Part I. Overview -- Defining insomnia / H.P. Attarian and M.L. Perlis -- Epidemiology of insomnia / Ritu Grewal and Karl Doghramji -- Physiological basis of insomnia / Michael H. Bonnet and Donna L. Arand -- Differential diagnosis of insomnia / Michael Saletu and Bernd Saletu -- Insomnia in primary care practice with a special focus for the midlevel practitioner / Nancy I. Resi -- Part II. Insomnia in special populations -- Behavioral insomnias of childhood: assessment and treatment / Daniel S. Lewin and Edward Huntley -- Insomnia in teens / John Garcia -- Insomnia during pregnancy / Beth Ann Ward -- Menopausal insomnia / Tarja Saaresranta, Päivi Polo-Kantola, and Olli Polo -- Sleep and aging: insomnia in the geriatric population / Clifford Singer and Francine Nanda -- Part III. The primary insomnias -- Psychophysiological insomnia / Mary B. O'Malley and Edward B. O'Malley -- Idiopathic insomnia / Garrick Applebee -- Paradoxical insomnia / Hrayr Attarian -- Sleep hygiene / Hrayr Attarian -- Part IV. The secondary insomnias -- Insomnia caused by medical disorders / Kenneth Plotkin -- Insomnia in neurological diseases and disorders / Federica Provini, Carolina Lombardi, and Elio Lugaresi -- Insomnia in psychiatric disorders / Samy S. Karaz -- Circadian rhythms and insomnia / Leon C. Lack and Helen R. Wright -- Insomnia secondary to sleep-related breathing disorders / Brooke G. Judd -- Insomnia as a presenting symptom of sleep-related movement disorders, hypersomnias and parasomnias / Keith J. Nagle -- Insomnia and pain disorders / Catherine C. Schuman and Melissa M. Clark -- Part V. Treatments -- Cognitive-behavioral therapy for insomnia / M.L. Perlis, M.T. Smith, C. Jungquist, S. Nowakowski, H. Orff, and J. Soeffing -- Pharmacological treatment of insomnia / Paula K. Schweitzer, Denise Troy Curry, Rhody D. Eisenstein, and James K. Walsh -- Part VI. Appendix. Contents/directory.

Introduction: Where new and old paths to dealing with suffering meet /Fabrizio Didonna --Part 1. Theory, conceptualization, and phenomenology --Mindfulness : What is it? Where did it come from? /Ronald D. Siegel, Christopher K. Germer, and Andrew Olendzki --Mindfulness and meditation /Andrew Olendzki --The neurobiology of mindfulness /Michael T. Treadway and Sara W. Lazar --Toward a phenomenology of mindfulness : subjective experience and emotional correlates /Kirk Warren Brown and Shari Cordon --Part 2. Clinical applications : general issues, rationale, and phenomenology --Mindfulness and psychopathology : problem formulation /Nancy L. Kocovski, Zindel V. Segal, Susan R. Battista --Emotional memory, mindfulness and compassion /Paul Gilbert and Dennis Tirch --The use of metaphor to establish acceptance and mindfulness /Alethea A. Varra, Claudia Drossel, and Steven C. Hayes --Mindfulness and feelings of emptiness /Fabrizio Didonna and Yolanda Rosillo Gonzalez --Assessment of mindfulness /Ruth A. Baer, Erin Walsh, Emily L.B. Lykins --Part 3. Mindfulness-based interventions for specific disorders --Mindfulness and anxiety disorders : developing a wise relationship with the inner experience of fear /Jeffrey Greeson, Jeffrey Brantley --Mindfulness and obsessive-compulsive disorder : developing a way to trust and validate one's internal experience /Fabrizio Didonna --Mindfulness-based cognitive therapy for depression and suicidality /Thorsten Barnhofer and Catherine Crane --Mindfulness and borderline personality disorder /Shireen L. Rizvi, Stacy Shaw Welch, and Sona Dimidjian --Mindfulness-based approaches to eating disorders /Ruth Q. Wolever and Jennifer L. Best --Paradise lost : mindfulness and addictive behavior /Thomas Bien --Mindfulness for trauma and posttraumatic stress disorder /Victoria M. Follette and Aditi Vijay --Mindful awareness and ADHD /L. Zylowska, S.L. Smalley, J.M. Schwartz --Mindfulness and psychosis /Antonio Pinto --Mindfulness-based stress reduction for chronic pain management /Jacqueline Gardner-Nix --Mindfulness-based interventions in oncology /Linda E. Carlson ... [et al.] --Part 4. Mindfulness-based interventions for specific settings and populations --Mindfulness-based intervention in an individual clinical setting : what difference mindfulness makes behind closed doors /Paul R. Fulton --Mindfulness with children : working with difficult emotions /Trudy A. Goodman and Susan Kaiser Greenland --Mindfulness-based elder care : communicating mindfulness to frail elders and their caregivers /Lucia McBee --Mindfulness-based interventions in an inpatient setting /Fabrizio Didonna --Training professionals in mindfulness : the heart of teaching /Susan Lesley Woods --Appendix A :Mindfulness practice /Thomas Bien and Fabrizio Didonna --Appendix B : Resources.

Congenital and perinatal infections -- Infectious disease emergencies with multiorgan involvement -- Common outpatient infections -- Immunizations -- Travel medicine -- Procedures -- Laboratory diagnosis -- Respiratory infections -- Gastrointestinal infections -- Bone and joint infections -- Urinary tract infections -- Skin and soft-tissue infections -- Central nervous system infections -- Surgical infections -- Sexually transmitted diseases and genital tract infections -- AIDS -- The immunocompromised host -- Systemic fungal infections -- Infection control -- Antimicrobial therapy.

Confidentiality and privilege -- Legal issues in emergency psychiatry -- Legal issues in inpatient psychiatry -- Malpractice and other forms of liability -- Competence and substitute decision-making -- Forensic evaluations -- Clinicians and lawyers -- The clinician in court.

Part 1: Introduction to clinical hematology --Morphology of human blood and marrow cells: hematopoiesis /Ann Bell, Denise M. Harmening, and Virginia C. Hughes --Bone marrow /Aamir Ehsan and Jennifer L. Herrick --The red blood cell: structure and function /Denise M. Harmening --Anemia: diagnosis and clinical considerations /Armand B. Glassman --Evaluation of cell morphology and introduction to platelet and white blood cell morphology /Kathy W. Jones --Part II: Anemias --Iron metabolism and hypochromic anemias /Kathleen Finnegan --Megaloblastic anemias /Mitra Taghizadeh --Aplastic anemia including pure red cell aplasia, congenital dyserythropoietic anemia, and paroxysmal nocturnal hemoglobinuria /Sherrie L. Perkins --Introduction to hemolytic anemias: intracorpuscular defects : Hereditary defects of the red cell membrane /Thérèsa L. Coetzer and Stan Zail --Hemolytic anemias: intracorpuscular defects : Hereditary enzyme deficiencies /Armand B. Glassman and Denise M. Harmening --Hemolytic anemias: intracorpuscular defects : The hemoglobinopathies /Denise M. Harmening, David Yang, and Hallye Zeringer --Hemolytic anemias: intracorpuscular defects : Thalassemia /Russell Aaron Higgins and Chantal Ricaud Harrison --Hemolytic anemias: extracorpuscular defects /Denise M. Harmening ... [et al.] --Hypoproliferative anemia: anemia associated with systemic diseases /Carmen J. Julius and Carl R. Schaub --Part III: White blood cell disorders --Cell biology, disorders of neutrophils, infectious mononucleosis, and reactive lymphocytosis /Denise M. Harmening, Joe Marty, and Ronald G. Strauss --Introduction to leukemia and the acute leukemias /Ken Gatter, Frank Cruz III, and Rita Braziel --Chronic myeloproliferative disorders I: chronic myelogenous leukemia /Carl R. Schaub --Chronic myeloproliferative disorders II: polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis /Kathrina Chua and Meyer R. Heyman --Myelodysplastic syndromes /Giovanni D'Angelo ... [et al.] --Chronic lymphocytic leukemia and related lymphoproliferative disorders /Laurel D. Holmer and Carlos E. Bueso-Ramos --The lymphomas /Dan M. Hyder --Multiple myeloma and related plasma cell disorders /Ashraf Z. Badros --Lipid (lysosomal) storage diseases and histiocytosis /Denise M. Harmening and Catherine M. Spier --Part IV: Hemostasis and introduction to thrombosis --Introduction to hemostasis /Denise M. Harmening, Claudia E. Escobar, and David L. McGlasson --Disorders of primary hemostasis: quantitative and qualitative platelet disorders and vascular disorders /Darla K. Liles and Charles L. Knupp --Disorders of plasma clotting factors /Sharon L. Schwartz --Interaction of the fibrinolytic, coagulation, and kinin systems; disseminated intravascular coagulation; and related pathology /John Lazarchick and Melanie Oswald --Introduction to thrombosis and anticoagulant therapy /Aamir Ehsan and Jennifer L. Herrick --Part V: Laboratory methods --Quality management, quality assurance, and quality control /Kim A. Przekop --Body fluid examination: the qualitative, quantitative, and morphologic analysis of serous, cerebrospinal, and synovial fluids /Sharon L. Schwartz --Hematology methods /Virginia C. Hughes --Principles of automated differential analysis /Denise M. Harmening ... [et al.] --Coagulation methods /Melissa Bethel --Applications of flow cytometry to hematopathology /Donna M. Gandour --Molecular diagnostic techniques in hematopathology /Margaret L. Gulley --Special stains/cytochemistry /Mary Loring Perkins, Denise M. Harmening, and Frank Xianfeng Zhao.

An introduction to hematology -- Principles of blood collection -- Molecular genetics and cellular morphology -- Hematopoiesis: bone marrow and blood -- Normal erythrocyte lifecycle and physiology -- Erythrocyte morphology and inclusions -- Classification and laboratory assessment of anemias -- Acute and chronic blood loss anemias -- Aplastic and related anemias -- Hypochromic anemias and disorders of iron metabolism -- - Megaloblastic anemias -- Hemolytic anemias -- The hemoglobinopathies -- Leukocytes: the granulocytic and monocytic series -- Leukocytes: nonmalignant disorders of granulocytes and monocytes -- Leukocytes: lymphocytes and plasma cells -- Leukocytes: Nonmalignant lymphocytic disorders -- Characteristics of leukemias and lymphomas -- Acute leukemias -- Malignant lymphoid and monocytic disorders and plasma cell dyscrasias -- Chronic myeloproliferative disorders -- Myelodysplastic syndromes -- Principles of hemostasis and thrombosis -- Disorders of hemostasis and thrombosis -- Body fluid analysis -- Manual procedures in hematology -- Instrumentation in hematology.

Structure and function of the liver. v. 1 -- Pathophysiology and morphology of liver injury. v. 1 -- Evaluation of the patient with hepatobiliary disease. v. 1 -- Diseases of the liver. v. 2 -- Diseases of the gallbladder and extrahepatic bile ducts. v. 2.

The human response system -- Organization of the immune system -- Innate immunity -- Antigen receptor genes, gene products, and co-receptors -- The major histocompatibility complex -- Antigens and antigen processing -- Antigen-presenting cells and antigen presentation -- B-cell development and differentiation -- T-cell development -- Cytokines and cytokine receptors -- Chemokines and chemokine receptors -- Lymphocyte adhesion and trafficking -- T-cell activation and tolerance -- Programmed cell death in lymphocytes -- Immunoglobulin function -- Regulatory T cells -- Helper T-cell subsets and control of the inflammatory response -- Cytotoxic lymphocyte function and natural killer cells -- Host defenses at mucosal surfaces -- Complement and complement deficiencies -- Phagocyte deficiencies -- Mast cells, basophils and mastocytosis -- Eosinophils and eosinophilia -- Immune response to extracellular bacteria -- Immune responses to intracellular bacteria -- Immune responses to spirochetes -- Immune responses to viruses -- Immune responses to protozoans -- Immune responses to helminths -- Evaluation of the immunodeficient patient -- Infections in the immunocompromised host -- Development of the fetal and neonatal immune system -- Aging and the immune system -- Primary antibody deficiencies -- Primnary T-cell immunodeficiencies -- Inherited disorders of IFN-g-, IFN-a/b-, and NF-kB-mediated immunity -- HIV infection and acquired immunodeficiency syndrome -- Immunodeficiency due to congenital, metabolic, infectious, surgical, and environmental factors -- Pathogenesis of asthma -- Management of the asthmatic patient -- Rhinitis and sinusitis -- Urticaria, angiodema, and anaphylaxis -- Allergic reactions to stinging and biting insects -- Atopic and contact dermatitis -- Food allergy -- Eosinophil-associated gastrointestinal disorders (EGID) -- Allergic disorders of the eye -- Durg hypersensitivity -- Occupational and environmental allergic disorders -- Mechanisms of autoimmunity --System lupus erythematosus -- Rheumatoid arthritis -- Juvenile idiopathic arthritis -- Sjogren's syndröme -- Systemic sclerosis -- Inflammatory muscle disease -- Spondyloarthritis -- Small- and medium-vessel primary vasculitis -- Large-vessel vasculitides -- Autoinflammatory fever syndromes -- Antiphospholipid syndrome -- Immunohematologic disorders -- Bullous diseases of the skin and mucous membranes -- Myasthenia gravis -- Multiple sclerosis -- Autoimmune peripheral neuropathies -- Immunology renal diseases -- Inflammation and atherothrombosis -- Autoimmune thyroid diseases -- Diabetes and related autoimmune diseases -- Immunologic lung diseases -- Sarcoidosis -- Immunologic ocular disease -- Immunologic disease of the gastrointestinal tract -- Inflammatory hepatobiliary cirrhosis -- Lymphoid leukemias -- Lymphomas including Hodkin lymphoma -- Monoclonal gammopathies -- Tumor immunology and immunotherapy -- Concepts and challenges in transplantation: rejection, immunosuppression and tolerance -- Challenges and potentials of xenotransplantation -- Hematopoietic stem cell transplantation for malignant diseases -- Stem cell transplantation and immune reconstitution -- thymic reconstitution -- Immunoglobulin therapy: replacement and immunomodulation -- Gene transfer therapy of immunologic diseases -- Glucocorticoids -- Nonsteroidal anti-inflammatory drugs -- Antihistamines -- Immunonodulating pharmaceuticals -- Protein kinase antagonists as therapeutic agents for immunological and inflammatory disorders -- Vaccines -- Immunotherapy of allergic disease -- Cytokine therapy -- Monoclonal antibodies and fusion proteins -- Assessment of proteins of the immune system -- Flow cytometry -- Assessment of functional immune responses -- Assessment of neutrophil function -- Assessment of human allergic diseases -- Molecular methods.Appendices: Selected CD molecules and their characteristics -- Laboratory reference values -- Chemokines -- Cytokines.

Historical overview of intelligence and memory : factors influencing the Wechsler scales / David S. Tulsky, Donald H. Saklofske, and Joseph H. Ricker -- Revising a standard : an evaluation of the origin and development of the WAIS-III / David S. Tulsky, Donald H. Saklofske, and Jianjun Zhu -- The Wechsler memory scale, third edition : a new perspective / David S. Tulsky ... [et al.] -- Assessment of cognitive functioning with the WAIS-III and WMS-III : development of a six-factor model / David S. Tulsky ... [et al.] -- Demographic effects and use of demographically corrected norms with the WAIS-III and WMS-III / Robert K. Heaton, Michael J. Taylor, and Jennifer Manly -- WAIS-III WMS-III discrepancy analysis : six-factor model index discrepancy base rates, implications, and a prelimary consideration of utility / Keith A. Hawkins and David S. Tulsky -- Diagnostic validity / Glenn E. Smith, Jane H. Cerhan, and Robert J. Ivnik -- Use of the WAIS-III and WMS-III in the context of serial assessments : interpreting reliable and meaningful change / Tara T. Lineweaver and Gordon J. Chelune -- Assessment of the non-native English speaker : assimilating history and research findings to guide clinical practice / Josette G. Harris, David S. Tulsky, and Maria T. Schultheis -- Accuracy of WAIS-III--WMS-III joint factor scores when one or more subtests is omitted or an alternate subtest is employed / Barton W. Palmer, Michael J. Taylor, and Robert K. Heaton -- Accomodating clients with disabilities on the WAIS-III and WMS / Jeffery P. Braden -- The WAIS-III and WMS-III : practical issues and frequently asked questions / Laura H. Lacritz and C.M. Cullum -- Appendix 1 : Pioneer's [sic] in the assessment of intelligence and memory / David S. Tulsky and Nancy D. Chiaravalloti -- Reviews and promotional material for the Wechsler-Bellevue and Wechsler memory scale / David S. Tulsky.

Leukemia. Acute myeloid leukemia. Acute lymphoblastic leukemia. Chronic myelogenous leukemia. Chronic lymphocytic leukemia. Hairy cell leukemia. Special topics in leukemia -- Myelodysplastic syndromes and myeloproliferative diseases. Myelodysplastic syndromes. Chronic myeloproliferative diseases -- Lymphoma. Non-Hodgkin's lymphoma. Hodgkin's lymphoma. Special topics in lymphoma -- Multiple myeloma and related disorders. Multiple myeloma. Special topics in multiple myeloma -- Stem cell transplantation -- Special topics in neoplastic hematology.

"This reference provides a current, multidisciplinary approach to the care of patients with intestinal failure. It includes intensive discussion on medical and nutritional issues especially relative to children with intestinal failure. It presents information on transplantation, but emphasizes rehabilitation. Topics cover etilogy/epidemiology, pathophysiology, and clinical assessment of intestinal failure in adults and pediatrics; medical and surgical management; prevention and treatment of complications of intestinal failure; nursing management; emerging diagnostic and therapeutic methods; and long term care. It is written by experts in nutrition, gastroenterology and pediatrics, pharmacy, as well as gastrointestinal surgery"--Provided by publisher.

History of electroconvulsive therapy / John L. Beyer -- Indications for use / John L. Beyer -- Patient referral and evaluation / John L. Beyer, Mehul V. Mankad -- Basics / Richard D. Weiner -- Clinical applications / Richard D. Weiner -- Anesthetics and other medications / Mehul V. Mankad, Richard D. Weiner -- Ictal motor response / Andrew D. Krystal -- Ictal electroencephalographic response / Andrew D. Krystal -- Cardiovascular response / Andrew D. Krystal -- Adverse effects / Mehul V. Mankad, Richard D. Weiner -- Managing the ECT seizure / Andrew D. Krystal -- Index ECT / Mehul V. Mankad -- Maintenance ECT / Mehul V. Mankad -- Step-by-step outline of ECT administration.

Normal aging -- Mood disorders: diagnosis -- Mood disorders: treatment -- Dementia and Alzheimer's disease -- Other dementias and delirium -- Anxiety disorders and late-onset psychosis -- Other common mental disorders of the elderly -- Competency and related forensic issues.

Pediatric psychosomatic medicine -- Coping and adaptation in physically ill children -- Pediatric consultation psychiatry assessment -- Legal and forensic issues -- Delirium -- Mood disorders -- Anxiety symptoms and disorders -- Somatoform disorders -- Pediatric pain -- Solid organ transplantation -- Treatment adherence -- Pediatric cancer, bone marrow transplantation, and palliative care -- Individual psychotherapy in the pediatric setting -- Family therapy -- Psychopharmacological approaches and considerations -- Preparation for procedures.

Principles of Magnetic Resonance / Wolfgang R. Nitz, Thomas Balzer, Daniel S. Grosu and Thomas Allkemper -- Magnetic Resonance Imaging of the Brain / Paul M. Parizel, Luc van den Hauwe, Frank De Belder, J. Van Goethem and Caroline Venstermans, et al. -- Magnetic Resonance Imaging of the Spine / Johan W. M. Van Goethem -- Magnetic Resonance Imaging of the Head and Neck / Bert De Foer, Bernard Pilet, Jan W. Casselman and Luc van den Hauwe -- Musculoskeletal System / Filip M. Vanhoenacker, Pieter Van Dyck, Jan Gielen, Arthur M. De Schepper and Paul M. Parizel -- Abdomen : Liver, Spleen, Biliary System, Pancreas, and GI Tract / Peter Reimer, Wolfgang Schima, Thomas Lauenstein and Sanjay Saini -- Abdomen : Retroperitoneum, Adrenals, Kidneys, and Upper Urinary Tract / Gertraud Heinz-Peer -- MRI of the Pelvis / Dow-Mu Koh and David MacVicar -- MRI of the Chest / Hans-Ulrich Kauczor and Edwin J. R Van Beek -- Heart / James F. M. Meaney and John Sheehan -- MR Angiography / James F. M. Meaney, John Sheehan and Mathias Boos -- MRI of the Breast / Uwe Fischer -- Magnetic Resonance Imaging of Pediatric Patients / Birgit Kammer, Hermann Helmberger, Claudia M. Keser, Eva Coppenrath and Karl Schneider -- Whole-Body MRI / Gerwin Schmidt, Dietmar Dinter, Stefan Schoenberg and Maximilian Reiser.

Part 1. Technical Considerations -- Technical Considerations / Nickolas Papanikolaou and Charalampos Mpougias -- Part 2. Contrast Agents -- MR Contrast Agents / Luís Curvo-Semedo and Filipe Caseiro-Alves -- Part 3. Liver and Biliary Tract -- Diffuse Parenchymal Disease / Luis Martí-Bonmatí and Lucía Flors Blasco -- Benign Focal Lesions / Bernard E. Van Beers and Valérie Vilgrain -- Hepatocellular Carcinoma / Carlo Bartolozzi, Valentina Battaglia and Elena Bozzi -- Primary and Secondary Liver Malignancies / Sukru Mehmet Erturk, Karin Herrmann and Pablo R. Ros -- Biliary Tract / Sylvain Terraz, Magalie Viallon and Christoph D. Becker -- Pearls and Pitfalls of Liver and Biliary Tract Imaging / Luis Martí-Bonmatí and Estela López-Pérez -- Part 4. Pancreas -- Ducts / Celso Matos and Sandra Baleato -- Parenchymal Disease / Thomas K. Helmberger -- Pearls and Pitfalls of Pancreatic Imaging / Celso Matos, Martina Pezzullo and Charikleia Triantopoulou -- Part 5. Spleen -- Spleen / Olle Ekberg -- Part 6. Adrenals -- Adrenal Incidentalomas / Marzena Kulawska-Didoszak and Gabriel P. Krestin -- Functioning Adrenal Pathology / Anju Sahdev and Rodney H. Reznek -- Pearls and Pitfalls of Imaging of the Adrenals / Marzena Kulawska-Didoszak and Gabriel P. Krestin -- Part 7. Kidneys -- Renal Masses / Roberto Pozzi Mucelli, Niccolò Faccioli and Riccardo Manfredi -- Excretory System / Claus Nolte-Ernsting -- Pitfalls of Imaging of the Kidneys / Roberto Pozzi Mucelli -- Part 8. Gut -- Small Bowel / Sofia Gourtsoyianni, Nicholas C. Gourtsoyiannis and Nickolas Papanikolaou -- MR Colonography / Thomas C. Lauenstein -- Rectum / Sofia Gourtsoyianni and Regina G. H. Beets-Tan -- Fistula-in-Ano / Steve Halligan and Stuart Taylor -- Pearls and Pitfalls of Imaging of the Small Bowel and Rectum / Regina G. H. Beets-Tan, Nickolas Papanikolaou and Nicholas C. Gourtsoyiannis -- Part 9. Pelvis -- Female Pelvis / Evis Sala and Rodney H. Reznek -- Prostate Gland / François Cornud and Nicholas Papanicolaou -- Pearls and Pitfalls of Imaging of the Pelvis / Anju Sahdev and Rodney H. Reznek -- Part 10. Pediatric Abdomen -- MR Imaging of Paediatric Abdomen / Michael Riccabona and Fred Avni -- Part 11. MRI Advances in Patients with Cancer -- Whole-Body MRI / Philip Aschoff, Claus D. Claussen and Heinz-Peter Schlemmer -- Diffusion-Weighted Imaging / Anwar R. Padhani and Shilpan M. Patel -- Target Volume Definition / Anju Sahdev and Rodney H. Reznek -- Part 12. Abdominal MRI at 3 Tesla -- 3 Tesla MR Imaging in the Abdomen / Pablo R. Ros and Sukru Mehmet Erturk.

Ch. 1The initial encounter: taking a history and recognition of neuro-ophthalmic emergencies --Ch. 2Visual loss of uncertain origin: diagnostic strategies --Ch. 3Functional anatomy of the human visual pathway --Ch. 4Perimetry --Ch. 5Diagnosis of pupillary disorders --Ch. 6Dyschromatopsias associated with neuro-ophthalmic disease --Ch. 7Electrophysiology --Ch. 8Optic disc signs and optic neuropathies --Ch. 9Neuro-ophthalmic aspects of orbital disease --Ch. 10Infranuclear disorders of ocular motility --Ch. 11Supranuclear disorders of ocular motility --Ch. 12Brain tumors relevant to clinical neuro-ophthalmology --Ch. 13Central disturbances of vision --Ch. 14Transient visual loss --Ch. 15Functional visual loss --Ch. 16Headache from a neuro-ophthalmic point of view --Ch. 17Drug-induced and toxic disorders in neuro-ophthalmology --Ch. 18Hereditary disorders of neuro-ophthalmic relevance --Ch. 19Pediatric neuro-ophthalmology --Ch. 20Neuroradiologic imaging --Ch. 21Neurology --Ch. 22Neurosurgery of the visual pathway --Ch. 23Radiotherapy for tumors of the anterior visual pathway --Ch. 24Reading disorders.

General organization -- Blood supply, meninges and spinal fluid -- Spinal cord -- Brain stem -- The Visual system -- Autonomic system and hypothalamus -- Cerebellum, basal ganglia and thalamus -- Cerebral cortex -- Clinical reviewMiniatlas.

Introduction and organization of the nervous system -- The neurobiology of the neuron and the neuroglia -- Nerve fibers, peripheral nerves, receptor and effector endings, dermatomes, and muscle activity -- The spinal cord and the ascending and descending tracts -- The brainstem -- The cerebellum and its connections -- The cerebrum -- The structure and functional localization of the cerebral cortex -- The reticular formation and the limbic system -- The basal nuclei (basal ganglia) and their connections -- The cranial nerve nuclei and their central connections and distribution -- The thalamus and its connections -- The hypothalamus and its connections -- The autonomic nervous system -- The meninges of the brain and spinal cord -- The ventricular system, the cerebrospinal fluid, and the blood-brain and blood-cerebrospinal fluid barriers -- The blood supply of the brain and spinal cord -- The development of the nervous system.

Introduction and organization of the nervous system -- The neurobiology of the neuron and the neuroglia -- Nerve fibers, peripheral nerves, receptor and effector endings, dermatomes, and muscle activity -- The spinal cord and the ascending and descending tracts -- The brainstem -- The cerebellum and its connections -- The cerebrum -- The structure and functional localization of the cerebral cortex -- The reticular formation and the limbic system -- The basal nuclei (basal ganglia) and their connections -- The cranial nerve nuclei and their central connections and distribution -- The thalamus and its connections -- The hypothalamus and its connections -- The autonomic nervous system -- The meninges of the brain and spinal cord -- The ventricular system, the cerebrospinal fluid, and the blood-brain and blood-cerebrospinal fluid barriers -- The blood supply of the brain and spinal cord -- The development of the nervous system.

MS: Pathology and Immunology -- MS: Epidemiology and Genetics -- MS: Clinical Features, Symptom Management, and Diagnosis -- Advances in Magnetic Resonance Imaging of Multiple Sclerosis -- Disease Modifying Agents in the Treatment of Multiple Sclerosis -- Pediatric Multiple Sclerosis -- Is Multiple Sclerosis a Vascular Disease? -- Multiple Sclerosis: The Next 20 Years -- Introduction to Neuroimmunology -- Acute Disseminated Encephalomyelitis -- Neuromyelitis Optica Spectrum Disorders -- The Neuroimmunology of Cancer -- Infections of the Central Nervous System -- The Neuroimmunology of Cortical Disease (Dementia, Epilepsy, and Autoimmune Encephalopathies) -- Autoimmune Movement Disorders -- CNS Vasculitis -- Principles of Immunotherapy -- Immunologic Disorders of Neuromuscular Junction and Muscle -- Autoimmune Neuropathies -- Systemic Autoimmune Diseases with Neurological Manifestations.

Overview of the vestibular system anatomy and physiology -- The peripheral vestibular system -- The central vestibular system -- Epidemiology of dizziness -- The history of the dizzy patient -- Bedside examination of the vestibular system -- Laboratory examinations of the vestibular system -- Clinical evaluation of hearing -- Infectious diseases -- Benign positional vertigo -- Endolymphatic hydrops (Meniere's syndrome) -- Migraine -- Immune-mediated diseases -- Vascular disorders -- Tumors -- Trauma -- Toxic/metabolic disorders -- Developmental and genetic disorders -- Antiemetic and antivertigo drugs -- Vestibular rehabilitation.

The practical nutritional assessment -- Body composition analysis -- Micronutrient deficiencies -- Clinical consequences of undernutrition -- The malabsorption syndrome -- The Dietary reference intakes: what are they and what do they mean? -- Dietary treatment of gastrointestinal diseases -- Macronutrient digestion, absorption, and metabolism -- Food allergies -- Dietary supplements: herbs and vitamins -- Prebiotics, probiotics, and dietary fiber -- Food and water safety: potential for bioterrorist attack -- Metabolic bone disease in gastrointestinal illness -- Nutrition in the elderly -- Nutrition and alcoholism -- Nutrition and diabetes mellitus -- Nutrition and colorectal cancer -- Nutritional support in inflammatory bowel disease -- Celiac disease -- Nutrition and liver disease -- Nutrition in chronic pancreatitis -- Nutritional support in acute pancreatitis -- Nutrition and gastrointestinal motility in health and disease -- Inborn errors of metabolism for the gastroenterologist -- Nutrition and cystic fibrosis -- Nutrition and gastrointestinal oncology -- The metabolic response to critical illness -- Clinical implications of oxidative stress and antioxidant therapy in gastrointestinal disease -- Perioperative nutritional support -- Dietary management in short bowel syndrome -- Nontransplant surgery for short bowel syndrome -- Intestinal transplantation -- The use of growth factors in short bowel syndrome -- Indications and contraindications to enteral and parenteral nutrition -- Vascular access for the patient receiving parenteral nutrition -- Parenteral nutrition formulas -- Pediatric parenteral nutrition -- Complications of long-term parenteral nutrition -- Complications of enteral nutrition -- Home parenteral nutrition in infants, children, and adults -- Administration routes for enteral nutrition -- Adult enteral nutrition: formulas and supplements -- Pediatric enteral formulas -- Home enteral nutrition -- Refeeding syndrome -- Medical, legal, and ethical aspects of nutritional support -- Medical management of obesity -- Control of food intake -- Surgical management of obesity -- Gastrointestinal complications of bariatric surgery -- Hyperlipidemia: genetic and nutritional considerations for the gastroenterologist -- Management of childhood obesity -- Nutritional support of obese and bariatric patients.

1Ocular examination techniques --2Imaging techniques --3Developmental malformations and anomalies --4Eyelids --5Lacrimal drainage system --6Orbit --7Dry eye disorders --8Conjunctiva --9Cornea --10Corneal and refractive surgery --11Episclera and sclera --12Lens --13Glaucoma --14Uveitis --15Ocular tumours and related conditions --16Retinal vascular disease --17Acquired macular disorders and related conditions --18Fundus dystrophies --19Retinal detachment --20Strabismus --21Neuro-ophthalmology --22Drug-induced disorders --23Trauma --24Systemic diseases.

Classifications and definitions -- Examination sequence for history and tests and measures -- Temporomandibular joint -- Cervical spine -- Thoracic spine -- Lumbar spine -- Pelvis -- Shoulder joint complex -- Elbow and forearm -- Wrist and hand -- Functional assessment of the upper extremity -- Hip joint -- Knee -- Foot and ankle -- Functional assessment of the lower extremity -- Posture -- Gait -- Other gait sequences -- Upper-extremity and lower-extremity neurodynamics.

The cardiovascular system -- The pulmonary system -- The renal system -- The gastrointestinal system -- The endocrine system -- The hematologic system -- The nervous system -- Rheumatology -- Male and female reproductive systems -- Cases.

Structure and development of the kidney -- Water and electrolyte handling by the kidney -- Disorders of mineral metabolism -- Epidemiology of renal disease in children -- Clinical assessment of renal function -- Diagnostic imaging of the urinary tract -- Radionuclide imaging -- Renal biopsy -- Hematuria and proteinuria -- Acute glomerulonephritis and rapidly progressive glomerulonephritis -- Nephrotic syndrome -- Inherited nephropathies -- Immunoglobulin A nephropathy and Henoch-Schönlein purpura nephritis -- Tubulointerstitial nephritis -- Hemolytic uremic syndrome -- Kidney in systemic lupus erythematosus and vasculitis -- Cystic kidney diseases -- Kidney in viral infections -- Sickle cell nephropathy -- Renal tubular acidosis -- Disorders of tubular transport -- Chronic kidney disease -- Renal osteodystrophy -- Acute renal failure -- Hemodialysis -- Peritoneal dialysis -- Continuous renal replacement therapy - Renal transplantation -- Nutrition in renal disease -- Hypertension: epidemiology and evaluation -- Mangement of hypertension in children and adolescents -- Syndromic renal disorders and malformations -- Obstructive uropathy -- Voiding disorders -- Urolithiasis -- Urinary tract infection -- Pediatric renal tumors.

Neonatal neurologic and neurosurgical disorders -- Chronic static encephalopathies -- Chronic progressive encephalopathies: inborn errors of metabolism -- Acute encephalopathy -- Traumatic brain injury -- Cerebrovascular disorders in children -- Neurocutaneous disorders -- Febrile seizures -- Epilepsy -- Headaches -- Movement disorders -- Ataxias -- Neuromuscular disorders -- Sleep disorders of childhood and adolescence -- Brain tumors -- Hydrocephalus -- Skull deformities: plagiocephaly and craniosynostosis -- The Chiari malformation and syringomyelia -- Spinal dysraphism and neurogenic bladder dysfunction.

This edition has been retitled Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response and also reflects the expansion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs.

Chapter 1. Cell function -- Chapter 2. Blood pressure -- Chapter 3. Electrolytes and acid-base metabolism -- Chapter 4. Evaluation of renal function -- Chapter 5. Evaluation of cardiac function -- Chapter 6. The respiratory system -- Chapter 7. Blood cells and blood coagulation -- Chapter 8. The immune system -- Chapter 9. Neurophysiology -- Chapter 10. The digestive system -- Chapter 11. The endocrine system.

From the Publisher: The new Sixth Edition of this award-winning classic prepares its users for delivering expert care in this most challenging nursing specialty. It addresses neuroanatomy, assessment, diagnostic evaluation, and management of the complete range of neurological disorders for which nurses provide patient care, including trauma, stroke, tumors, seizures, headache, aneurysms, infections, degenerative disorders, and peripheral neuropathies. This edition has been thoroughly revised to reflect standards of care based on evidence-based practice. It now includes case studies, community nursing sections throughout, and increased coverage of normal pressure hydrocephalus, inflammatory demyelinating polyneuropathy, and Creutzfeld-Jacob disease.

The hospital team -- Surgery and surgical teams -- Anesthesia -- Selected hospital medical units -- General departments -- Index of procedures -- Introduction -- Abdominal wall defect repair -- Ambulatory ECG monitoring -- Amniocentesis -- Anesthesia, general -- Anesthesia, local -- Angiography -- Angioplasty -- Aortic aneurysm graft -- Appendectomy -- Arthroscopy of knee -- Bariatric surgery -- Biopsy, bone marrow -- Biopsy, breast -- Biopsy, liver -- Biopsy, lung -- Biopsy, prostate -- Bladder suspension -- Blood pressure measurement -- Blood trasfusion -- Breast augmentation surgery -- Breast reduction surgery -- Caesarean section -- Cardiac output measurement -- Carotid endarterectomy -- Cataract removal -- Chemotherapy -- Cholecystectomy -- Circumcision -- Colonoscopy -- Colostomy -- Cornea transplant -- Coronary artery bypass graft -- Craniotomy -- Cystectomy -- Cystoscopy -- Defibrillation -- Dilatation and curettage -- Discectomy -- Electrocardiogram -- Electroconvulsive therapy -- Electroencephalogram -- Episiotomy -- Fetal monitoring -- Gastrectomy -- Heart transplant -- Heart valve surgery -- Hemodialysis -- Hemorrhoidectomy -- Hip arthroplasty -- Hysterectomy -- Hysteroscopy -- Ileostomy -- In vitro fertilization -- Incisional hernia surgery -- Inguinal hernia repair -- INTACS -- Kidney transplant -- Knee arthroplasty -- Labor and delivery -- Laminectomy -- Laryngectomy -- LASIK -- Lithotripsy -- Liver transplant -- Mastectomy, lumpectomy -- Mastectomy, radical -- Mastectomy, simple -- Myringotomy -- Pacemaker application -- Patent ductus arteriosus repair -- Peritoneal dialysis -- Prostate surgery -- Pulse oximetry -- Radiation therapy -- Septoplasty -- Shunt for hydrocephalus -- Splenectomy -- Stress test -- Thyroidectomy -- Tonsillectomy -- Total parenteral nutrition -- Tracheostomy -- Tubal ligation -- Uterine ablation -- Vasectomy.

Overview and introduction to clinical proteomics / Young-Ki Paik ... [et al.] -- Specimen collection and handling : standardization of blood sample collection / Harald Tammen -- Tissue sample collection for proteomics analysis / Jose I. Diaz, Lisa H. Cazares, and O. John Semmes -- Protein profiling of human plasma samples by two-dimensional electrophesis / Sang Yun Cho ... [et al.] -- Analysis of laser capture microdissected cells by 2-dimensional gel electrophoresis / Daohai Zhang and Evelyn Siew-Chuan Koay -- Optimizing the difference gel electrophesis (DIGE) technology / David B. Friedman and Kathryn S. Lilley -- MALDI/SELDI protein profiling of serum for the identification of cancer biomarkers / Lisa H. Cazares ... [et al.] -- Urine sample preparation and protein profiling by two-dimensional electrophoresis and matrix-assisted laser desorption ionization time of flight mass spectroscopy / Panagiotis G. Zerefos and Antonia Vlahou -- Combining laser capture microdissection and proteomics techniques / Dana Mustafa, Johan M. Kros, and Theo Luider -- Comparison of protein expression by isotope-coded affinity tag labeling / Zhen Xiao and Timothy D. Veenstra -- Analysis of microdissected cells by two-dimensional LC-MS approaches / Chen Li ... [et al.] -- Label-free LC-MS method for the identification of biomarkers / Richard E. Higgs ... [et al.] -- Analysis of the extracellular matrix and secreted vesicle proteomes by mass spectrometry / Zhen Xiao ... [et al.] -- Miniaturized parallelized sandwich immunoassays / Hsin-Yun Hsu, Silke Wittemann, and Thomas O. Joos -- Dissecting cancer serum protein profiles using antibody arrays / Marta Sanchez-Carbayo -- 2D-PAGE maps analysis / Emilio Marengo, Elisa Robotti, and Marco Bobba -- Finding the significant markers : statistical analysis of proteomic data / Sebastien Christian Carpentier ... [et al.] -- Web-based tools for protein classification / Costas D. Paliakasis, Ioannis Michalopoulos, and Sophia Kossida -- Open-source platform for the analysis of liquid chromatography-mass spectrometry (LC-MS) data / Matthew Fitzgibbon ... [et al.] -- Pattern recognition approaches for classifying proteomic mass spectra of biofluids / Ray L. Somorjai.

Ch. 1. Clinical psychology for cardiac disease / E. Molinari, L. Bellardita, A. Compare -- Pt. I. Psychological risk factors for cardiac disease. Ch. 2. Psychological risk factors for cardiac disease and pathophysiological mechanisms: an overview / A. Compare, L. Gondoni, E. Molinari -- Ch. 3. Psychophysiology of heart disease / G. Parati, M. Valentini, G. Mancia -- Ch. 4. Mental stress ischemia: characteristics, pathophysiology, prognosis and treatment / M.M. Burg -- Ch. 5. Depression and CHD: prevalence, prognosis, pathophysiology and treatment / K. Maier, D. Chatkoff, M.M. Burg -- Ch. 6. Prevalence of depression in chronic heart failure / E.P. Havranek -- Ch. 7. Depression in coronary artery disease: assessment and treatment / W.J. Kop, D.N. Ader -- Ch. 8. Anxiety and heart disease / D.K. Moser, M.J. De Jong -- Ch. 9. Anxiety, depressive symptoms and heart transplantation / S. Zipfel et al. -- Ch. 10. Psychological factors in hypertension development and treatment / T. Rutledge -- Ch. 11. Type A, Type D, anger-prone behavior and risk of relapse in CHD patients / A. Compare, G.M. Manzoni, E. Molinari -- Ch. 12. Defensive hostility and cardiovascular disease: theoretical and empirical bases for an interpersonal approach-avoidance conflict perspective / R.S. Jorgensen, R. Thibodeau -- Ch. 13. In sickness and in health: interpersonal risk and resilience in cardiovascular disease / J.M. Ruiz et al. -- Ch. 14. Psychological stress in women: the Stockholm Female Coronary Risk Study / K. Orth-Gomèr -- Ch. 15. Application of neural networks and other artificial adaptive systems in prediction and data mining of risk psychological profile for CHD / E. Grossi, A. Compare -- Ch. 16. Person measurement and rehabilitation outcome: the new perspective of Rasch analysis / L. Tesio -- Interlude. The "heart" of cardiology: an imaginary conversation with Bernard Lown / E. Molinari -- Pt. II. Psychological treatment in cardiac rehabilitation. Ch. 17. The art of listening to cardiac patient and his family: the meanings of suffering along temporal dimension / A. Compare, M. Simioni -- Ch. 18. Interpersonal psychotherapy for depression in patients with coronary heart disease / D. Koszycki -- Ch. 19. Hanging onto a heartbeat: emotionally focused therapy for couples dealing with the trauma of coronary heart disease / H.B. MacIntosh, S.M. Johnson, A. Lee -- Ch. 20. Type A behavior pattern and its treatment / A.T. Möller -- Ch. 21. Relaxation techniques and hypnosis in the treatment of CHD patients / L. Bellardita, M. Cigada, E. Molinari -- Ch. 22. Cardiological and psychological mobile care through telematic technologies for heart failure patients: ICAROS Project / A. Compare et al. -- Ch. 23. Functioning and disability in patients with cardiovascular disease within the ICF classification framework: proposals for using ICF to classify functioning and disability in patients with cardiovascular disease / M. Leonardi, A. Raggi -- Ch. 24. Coherence-building techniques and heart rhythm coherence feedback: new tools for stress reduction, disease prevention and rehabilitation / R. McCraty, D. Tomasino.

Overview and principles of diagnostic imaging -- Radiographic contrast agents -- Interventional and invasive radiology -- Pulmonary imaging -- Cardiac imaging -- Breast imaging -- Abdominal radiographs -- Gastrointestinal imaging -- Urinary tract imaging -- Urinary tract imaging -- Obstetric and gynecologic imaging -- Musculoskeletal imaging -- Cranial imaging -- Vertebral imaging.

pt. 1. Contexts of clinical research informatics -- pt. 2. Data management and systems in clinical research -- pt. 3. Knowledge representation and discovery -- pt. 4. The future of clinical research, health, and clinical research informatics.

Planning the research / Eugene Blackstone -- Ethical issues in clinical research / David F. Penson -- Budget development and staffing / Judith Fine and Peter C. Albertsen -- Non randomized interventional study designs (quasi-experimental designs) / David Axelrod, Rodney Hayward -- Randomized clinical trials of surgical procedures / Michael P. Porter -- Use of observational databases (registries) in research / Deborah P. Lubeck -- Risk adjustment / William G. Henderson and Shukri F. Khuri -- Basic statistical methods / David Etzioni, Nadia Howlader, and Ruth Etzioni -- Survival analyses / Rodney L. Dunn and John T. Wei -- Assessing the performance and validity of diagnostic tests and screening programs / David C. Miller, Rodney L. Dunn, and John T. Wei -- Secondary data analyses / Andrew Rosenberg, MaryLou VH Greenfield, and Justin B. Dimick -- Traditional outcome measures / Aruna V. Sarma, and Julie C. McLaughlin -- Health-related quality of life / Mark Litwin -- Measuring patient satisfaction / Arvin Koruthu George and Martin G. Sanda -- Quality of care / Jessica B. O'Connell and Clifford Y. Ko -- Cost-effectiveness analyses / Lynn Stothers -- Qualitative research / Donna L. Berry, Sally L. Maliski, and William J. Ellis -- Systematic reviews and meta-analyses / Timothy J. Wilt and Howard A. Fink.