BookJosé A. Stoute, editor.
Summary: References; Role of Complement in Severe Malarial Anemia; The Problem of Severe Malarial Anemia; Evidence of Complement Activation During Malaria; Evidence of Opsonoization and Changes in the Expression of Complement Regulatory Proteins on Uninfected Erythrocytes of Patients with Malaria; Genetic Association Studies; Directions for Future Research; References; Role of Complement in Cerebral Malaria; The Impact of Malaria/Cerebral Malaria; Clinical Features of Cerebral Malaria; Molecular Features of CM; Complement Synthesis in the Periphery and Central Nervous System.
Contents:
Intro; Dedication; Preface; Contents; Contributors; The Complement System; Introduction; Classical Pathway; Lectin Pathway; Alternative Pathway; Terminal Complement Activation; Extrinsic Complement Activation Pathways; Anaphylatoxins; Complement Regulators; Soluble Complement Regulators; Surface-Bound Complement Regulators; Complement Receptors; References; Mechanisms of Complement Activation in Malaria; Introduction; Malaria Biology; Measures of Complement Activation; Immune Complexes Activate the CP of Complement. Complement and Malaria/Cerebral MalariaComplement in Murine Models of Cerebral Malaria; Complement Gene-Targeted and Transgenic Mice in ECM; Classical Pathway; Lectin Pathway; Alternative Pathway; Anaphylatoxin Receptors and Anaphylatoxins; C3 and C5; Terminal Pathway; Complement Phagocytic Receptors and Regulatory Proteins; Integrating the Role of Complement in ECM; Complement-Mediated Therapeutic Approaches to Cerebral Malaria; References; Complement and Malaria in Pregnancy; Global Burden of Malaria Infection During Pregnancy; Pathophysiology of Malaria in Pregnancy. The Role of Complement Activation in Pregnancy ComplicationsComplement Activation in Pregnancy; Complement in Non-malarial Pregnancy Pathologies; The Role of Complement Activation in Malaria in Pregnancy; Emerging Evidence of Complement Activation in MiP and Fetal Neurodevelopment; Therapeutic Potential of Targeting Complement Activation in MiP; Conclusions; References; Complement Evasion Mechanisms of the Human Pathogen Plasmodium falciparum; Merozoite Invasion into Red Blood Cells; Merozoite Surface Proteins; 6-Cysteine Family of Merozoite Surface Proteins.