Books

::Summary## Point and click your way to performing statistics! Many people are intimidated by learning statistics, but A Gentle Introduction to Statistics Using SAS Studio in the Cloud is here to help. Whether you need to perform statistical analysis for a project or, perhaps, for a course in education, psychology, sociology, economics, or any other field that requires basic statistical skills, this book teaches the fundamentals of statistics, from designing your experiment through calculating logistic regressions. Serving as an introduction to many common statistical tests and principles, it explains concepts in an intuitive way with little math and very few formulas. The book is full of examples demonstrating the use of SAS Studio's easy point-and-click interface accessed with SAS OnDemand for Academics, an online delivery platform for teaching and learning statistical analysis that provides free access to SAS software via the cloud. Topics included in this book are: How to access SAS OnDemand for Academics Descriptive statistics One-sample tests T tests (for independent or paired samples) One-way analysis of variance (ANOVA) N-way ANOVA Correlation analysis Simple and multiple linear regression Binary logistic regression Categorical data, including two-way tables and chi-square Power and sample size calculations Questions are provided to test your knowledge and practice your skills.<br/>::Contents##<br/>Descriptive and inferential statistics<br/>Study designs<br/>What is SAS OnDemand for academics?<br/>SAS Studio tasks<br/>Importing data into SAS<br/>Descriptive statistics : univariate analysis<br/>One-sample tests<br/>Two-sample tests<br/>Comparing more than two means (ANOVA)<br/>N-Way ANOVA<br/>Correlation<br/>Simple and multiple regression<br/>Binary logistic regression<br/>Analyzing categorical data<br/>Computing power and sample size<br/>Solutions to the Odd-Numbered exercises

::Contents##<br/>Caring for critically ill children and their families<br/>Pulmonary system<br/>Cardiovascular system<br/>Neurologic system<br/>Renal system<br/>Endocrine system<br/>Gastrointestinal system<br/>Hematology and immunology systems<br/>Multisystem issues<br/>Professional issues: quality, safety, work environment, and wellness.

::Summary## "Succinct, complete guidance on how to safely and competently care for adult, critically ill patients and their families written by top clinical experts. Endorsed by the American Association of Critical-Care Nurses (AACN), this acclaimed textbook sets the standard for critical care nursing education. Recognizing the learner's need to assimilate foundational knowledge before attempting to master more complex critical care nursing concepts, the book features a practical building-block organization that starts with the basics and logically progresses to advanced topics. Bolstered by helpful tables and essential content cases, AACN Essentials of Critical Care Nursing is an essential tool for clinicians at the point of care, and those preparing for CCRN® certification in critical care nursing. AACN Essentials of Critical Care Nursing, Fourth Edition is presented in four sections: The Essentials presents core information that new clinicians must understand to provide safe, competent nursing care to all critically ill patients, regardless of their underlying medical diagnoses. Pathologic Conditions covers pathologic conditions and management strategies commonly encountered among adult critical care patients. Advanced Concepts in Caring for the Critically Ill Patient moves beyond the essentials and includes information about specific pathologic conditions that require specialized critical care management. Key Reference Information features normal laboratory and diagnostic values, troubleshooting guides for hemodynamic monitoring, summary tables of critical care drugs, and cardiac rhythms and treatment guides. Learning aids include Knowledge Competencies that can be used to gauge progress, Principles of Management to summarize key concepts and "Essential Content" case studies with questions and answers to further reinforce the learners' knowledge"-- Provided by publisher.<br/>::Contents##<br/>Section I: The essentials. Assessment of critically ill patients and their families / Mary Fran Tracy<br/>Planning care for critically ill patients and their families / Mary Fran Tracy<br/>Interpretation and management of basic cardiac rhythm / Carol Jacobson<br/>Hemodynamic monitoring / Leanna R. Miller<br/>Airway and ventilatory management / Robert E. St. John and Maureen A. Seckel<br/>Pain, sedation, and neuromuscular blockade management / Yvonne D'Arcy and Sara Knippa<br/>Pharmacology / Earnest Alexander<br/>Ethical and legal considerations / Sarah A. Delgado. Section II: Pathologic conditions. Cardiovascular system / Barbara Leeper<br/>Respiratory system / Maureen A. Seckel<br/>Multisystem problems / Julie Grishaw<br/>Neurologic system / John C. Bazil and Daiwai Olson<br/>Hematologic and immune systems / Diane K. Dressler<br/>Gastrointestinal system / Beth Quatrara<br/>Renal system / Jie Chen<br/>Endocrine system / Mary E. Lough<br/>Trauma / Alan C. Wolfe Jr. and Benjamin W. Hughes. Section III: Advanced concepts. Advanced ECG concepts / Carol Jacobson<br/>Advanced cardiovascular concepts / Barbara Leeper<br/>Advanced respiratory concepts: modes of ventilation / John J. Gallagher<br/>Advanced neurologic concepts / John C. Bazil and Daiwai Olson. Section IV: Key reference information. Normal laboratory reference values / Suzanne M. Burns and Sarah A. Delgado<br/>Pharmacology tables / Earnest Alexander<br/>Hemodynamic monitoring troubleshooting guide / Leanna R. Miller<br/>Cardiac rhythms, ECG characteristics, and treatment guide / Carol Jacobson.

::Summary## "Succinct, complete guidance on how to safely and competently care for adult progressive care patients and their families written by top clinical experts Endorsed by the American Association of Critical-Care Nurses (AACN), this acclaimed textbook sets the standard for progressive care nursing education. Recognizing the learner's need to assimilate foundational knowledge before attempting to master more complex progressive care nursing concepts, the book features a practical building-block organization that starts with the basics and logically moves on to advanced topics. Bolstered by helpful tables and Essential Content cases, AACN Essentials of Progressive Care Nursing, Fourth Edition is an essential tool for clinicians at the point of care, and those preparing for PCCN® certification in progressive care nursing. AACN Essentials of Progressive Care Nursing is divided into four sections: The Essentials presents essential information that clinicians must understand to provide safe, competent nursing care to progressive care patients, regardless of their underlying medical diagnoses. Pathologic Conditions covers pathologic conditions and management strategies commonly encountered among adult, progressive care patients. Advanced Concepts in Caring for the Progressive Care Patient presents advanced progressive care concepts or pathologic conditions that are less common or require more specialized management. Key Reference Information features normal laboratory and diagnostic values; pharmacology tables; and summary tables of cardiac rhythms, ECG characteristics, and treatment guides. Learning aids include Knowledge Competencies to gauge progress, Principles of Management to summarize key concepts, and "Essential Content" case studies with questions and answers to further reinforce the learners' knowledge"-- Provided by publisher<br/>::Contents##<br/>Assessment of progressive care patients and their families<br/>Planning care for progressive care patients and their families<br/>Interpretation and management of basic cardiac rhythms<br/>Hemodynamic monitoring<br/>Airway and ventilatory management<br/>Pain and sedation management<br/>Pharmacology<br/>Ethical and legal considerations<br/>Cardiovascular system<br/>Respiratory system<br/>Multisystem problems<br/>Neurological system<br/>Hematologic and immune systems<br/>Gastrointestinal system<br/>Renal system<br/>Endocrine system<br/>Trauma<br/>Advanced ECG concepts<br/>Advanced cardiovascular concepts<br/>Advanced neurologic concepts<br/>Normal laboratory reference values<br/>Pharmacology tables<br/>Cardiac rhythms, ECG characteristics, and treatment guide.

::Summary## The AACN Procedure Manual for High Acuity, Progressive, and Critical Care, 7th Edition, authored by the American Association of Critical-Care Nurses, is the authoritative reference to procedures performed in high acuity, progressive, and critical care settings. It visually guides you through procedures unique to the adult critical care environment, including those performed by advanced practice nurses, in an illustrated, step-by-step format. This edition features 17 new procedures, new illustrations, and updated content throughout, reflecting the latest evidence-based guidelines and national and international protocols.<br/>::Contents##<br/>Unit I: Pulmonary system<br/>Sect. One: Airway management<br/>Sect. Two: Special pulmonary procedures<br/>Sect. Three: Thoracic cavity management<br/>Sect. Four: Ventilatory management<br/>Unit II: Cardiovascular system<br/>Sect. Five: Cardiac emergencies<br/>Sect. Six: Cardiac pacemakers<br/>Sect. Seven: Circulatory assist devices<br/>Sect. Eight: Electrocardiographic leads and cardiac monitoring<br/>Sect. Nine: Hemodynamic monitoring<br/>Sect. Ten: Special cardiac procedures<br/>Sect. Eleven: Vascular access<br/>Unit III: Neurologic system<br/>Sect. Twelve: Neurologic monitoring<br/>Sect. Thirteen: Special neurologic procedures<br/>Sect. Fourteen: Traction management<br/>Sect. Fifteen: Pain management<br/>Unit IV: Gastrointestinal system<br/>Sect. Sixteen: Special gastrointestinal procedures<br/>Unit V: Renal system<br/>Sect. Seventeen: Renal replacement<br/>Unit. VI: Hematologic system<br/>Sect. Eighteen: Fluid management<br/>Sect. Nineteen: Special hematologic procedures<br/>Unit VII: Integumentary system<br/>Sect. Twenty: Burn wound management<br/>Sect. Twenty-one: Special integumentary procedures<br/>Sect. Twenty-two: Wound management<br/>Unit VIII: Nutrition<br/>Unit IX: Calculating medication doses. Unit I: Pulmonary System. Section one: Airway Management / Michael W. Day<br/>Combitube insertion and removal / Kyle Gibson ; Endotracheal intubation (perform) / Cindy Goodrich ; Endotracheal intubation (assist) / Cindy Goodrich ; Endotracheal tube and oral care practices for ventilated and non-ventilated patients / Kathleen Vollman, Mary Lou Sole, Barbara Quinn ; Extubation/decannulation (perform) / Lisa Koser ; Extubation/decannulation (assist) / Lisa Koser ; King Airway insertion and removal / Kyle Gibson ; Laryngeal mask airway / Stephen Both ; Nasopharyngeal and oral airway insertion / Kimberly Wright ; Suctioning: endotracheal or tracheostomy tube / Maureen A. Seckel ; Surgical cricothyrotomy (perform) / Roger Casey ; Surgical cricothyrotomy (assist) / Roger Casey ; Tracheostomy cuff and tube care / Renee Johnson<br/>Section two: special pulmonary procedures / Michael W. Day<br/>Continuous end-tidal carbon dioxide monitoring / Paul Luehrs ; Continuous lateral rotation therapy / Jamie St. Clair, Jennifer Macdermott ; Continuous venous oxygen saturation monitoring / Joni L. Dirks ; Extracorporeal life support (ECLS) and extracorporeal membrane oxygenation (ECMO) / Thomas Lawson, Marcia Belcher ; Oxygen saturation monitoring with pulse oximetry / Donna Barge Lee ; Pronation therapy / Kathleen Vollman, Sharon Dickinson, Jan Powers<br/>Section three: thoracic cavity management / Michael W. Day<br/>Autotransfusion / Kelly McGinty ; Chest tube placement (perform) / Julie Waters ; Chest tube placement (assist) / Julie Waters ; Chest tube removal (perform) / Peggy Kirkwood ; Chest tube removal (assist) / Peggy Kirkwood ; Closed chest drainage system / Joya D. Pickett ; Needle thoracostomy (perform) / Cindy Goodrich ; Thoracentesis (perform) / Susan Yeager ; Thoracentesis (assist) / Susan Yeager<br/>Section four: ventilatory management / Michael W. Day<br/>Invasive mechanical ventilation (through an artificial airway): volume and pressure modes / John Gallagher ; Noninvasive positive pressure ventilation: continuous positive airway pressure (CPAP) and bilevel positive airway pressure (BiPAP) / Susan K. Frazier ; Manual self-inflating resuscitation bag-valve device / Thomas Levins ; Peripheral nerve stimulators / Nathan W. Howard ; Weaning mechanical ventilation / Susan K. Frazier<br/>Unit II: cardiovascular system. Section five: cardiac emergencies / Debra L. Wiegand<br/>Automated external defibrillation / Kiersten Henry ; Cardioversion / Cynthia Hambach ; Defibrillation (external) / Cynthia Hambach ; Defibrillation (internal) perform / Marion E. McRae ; Defibrillation (internal) assist / Marion E. McRae ; Emergent open sternotomy (perform) / Alice Chan ; Emergent open sternotomy (assist) / Alice Chan ; External wearable cardioverter defibrillator / Kiersten Henry ; Pericardiocentesis (perform) Kathleen M. Cox ; Pericardiocentesis (assist) / Kathleen M. Cox<br/>Section six: cardiac pacemakers / Debra L. Wiegand<br/>Atrial electrogram / Marion E. McRae ; Atrial overdrive pacing (perform) / Jillian Hamel ; Epicardial pacing wire removal / Marion E. McRae ; Implantable cardioverter-defibrillator / Kiersten Henry ; Permanent pacemaker (assessing function) / Valerie Spotts ; Temporary transcutanous (external) pacing / Valerie Spotts ; Temporary transvenous pacemaker insertion (perform) / Nikki Taylor ; Temporary transvenous and epicardial pacing / Valerie Spotts<br/>Section seven: circulatory assist devices / Debra L. Wiegand<br/>Intraaortic balloon pump management / John P. Harper ; Ventricular assist devices / Mark Puhlman, Angela Bingham – Section eight: electrocardiographic leads and cardiac monitoring / Debra L. Wiegand<br/>Cardiac monitoring and electrocardiographic leads / Michele M. Pelter, Teri M. Kozik, Mary G. Carey ; Extra electrocardiographic leads: right precordial and left posterior leads / Shu-Fen Wung ; ST-segment monitoring (continuous) / Mary G. Carey, Michele M. Pelter ; Twelve-lead electrocardiogram / Shu-Fen Wung<br/>Section nine: hemodynamic monitoring / Debra L. Wiegand<br/>Arterial catheter insertion (perform) / Hillary Crumlett, Alex Johnson ; Arterial catheter insertion (assist), care, and removal / Hillary Crumlett, Alex Johnson ; Arterial pressure-based cardiac output monitoring / Susan Scott ; Blood sampling from an arterial catheter / Hillary Crumlett, Alex Johnson ; Blood sampling from a central venous catheter / Kathleen M. Cox ; Blood sampling from a pulmonary artery catheter / Kathleen M. Cox ; Cardiac output measurement techniques (invasive) / Susan Scott ; Central venous catheter removal / Jillian Hamel ; Central venous catheter site care / Jillian Hamel ; Central venous/right atrial pressure monitoring / Reba McVay ; Esophageal cardiac output monitoring: perform / Alexander Johnson, Hillary Crumlett ; Esophageal cardiac output monitoring: assist / Alexander Johnson, Hillary Crumlett ; Non-invasive cardiac output monitoring / Susan Scott ; Pulmonary artery catheter insertion (perform) / Nikki Taylor ; Pulmonary artery catheter insertion (assist) and pressure monitoring / Reba McVay ; Pulmonary artery catheter removal / Nikki Taylor ; Pulmonary artery catheter and pressure lines, troubleshooting / Reba McVay ; Single-pressure and multiple-pressure transducer systems / Reba McVay<br/>Section ten: special cardiac procedures / Debra L. Wiegand<br/>Femoral arterial and venous sheath removal / Rose B. Shaffer ; Radial arterial sheath removal / Rose B. Shaffer ; Pericardial catheter management / Kathleen M. Cox ; Thenar tissue oxygen saturation monitoring / Kathleen Berns ; Transesophageal echocardiography (assist) / Janice Y. Dawson, Linda Hoke<br/>Section eleven: vascular access / Debra L. Wiegand<br/>Arterial puncture / Joel M. Brown II ; Central venous catheter insertion (Perform) / Susan Yeager ; Central venous catheter insertion (Assist) / Susan Yeager ; Implantable venous access device: access, deaccess, and care / Anne Delengowski ; Intraosseus devices / Michael W. Day ; Midline catheters / Debra L. Wiegand ; Peripherally inserted central catheter / Debra L. Wiegand<br/>Unit III: neurologic system. Section twelve: neurologic monitoring / Mary Beth Flynn Makic<br/>Bispectral index monitoring / Richard B. Arbour ; Brain tissue oxygenation monitoring: insertion (assist), care, and troubleshooting / Megan T. Moyer, Eileen Maloney Wilensky ; Cerebral blood flow monitoring / Tracey M. Berlin ; Cerebral micodialysis / Sandy Cecil ; Intracranial bolt and fiberoptic catheter insertion (assist), intracranial pressure monitoring, care, troubleshooting, and removal / Tess Slazinski ; Intraventricular/fiberoptic catheter insertion (assist), monitoring, nursing care, troubleshooting, and removal / Tess Slazinski ; Intraventricular catheter with external transducer for cerebrospinal fluid drainage and intracranial pressure monitoring / Stephanie Cox ; Lumbar subarachnoid catheter insertion (assist) for cerebrospinal fluid drainage and pressure monitoring / Nicolle Schraeder<br/>Section thirteen: special neurologic procedures / Mary Beth Flynn Makic<br/>Lumbar puncture (perform) / Susan Chioffi ; Lumbar puncture (assist) / Susan Chioffi ; Pupillometer / DaiWai M. Olson, John C. Bazil ; Rotorest lateral rotation surface / Theresa Nino, Mary Beth Flynn Makic ; Thermoregulation: external and intravascular warming & cooling Devices / Karen A. Lovett<br/>Section fourteen: traction management / Mary Beth Flynn Makic<br/>Cervical tongs or halo ring: application for use in cervical traction (assist) / Jennifer Massetti ; Cervical traction maintenance / Jennifer Massetti ; Halo ring and vest care / Cara Diaz ; Pin site care: cervical tongs and halo pins / Cara Diaz<br/>Section fifteen: pain management / Eleanor Fitzpatrick<br/>Epidural catheters: assisting with insertion and pain management / Kimberly Williams ; Patient-controlled analgesia / Lorie Ann Meek ; Peripheral nerve blocks: assisting with insertion and pain management / Kimberly Williams<br/>Unit IV: gastrointestinal system. Section sixteen: special gastrointestinal procedures / Eleanor Fitzpatrick<br/>Esophagogastric tamponade tube / Rosemary Lee ; Focused assessment with sonography in trauma / Cynthia Blank-Reid, Thomas A. Santora ; Gastric lavage in hemorrhage and overdose / Ann Will Poteet ; Endoscopic therapy / Eleanor Fitzpatrick ; Intraabdominal pressure monitoring / Rosemary Lee ; Nasogastric and orogastric tube insertion, care, and removal / Carol McGinnis ; Molecular adsorbents recirculation system (MARS) / Mary D. Still ; Paracentesis (perform) / Eleanor Fitzpatrick ; Paracentesis (assist) / Eleanor Fitzpatrick ; Peritoneal lavage (perform) / Kate Deis ; Peritoneal lavage (assist) / Kate Deis<br/>Unit V: renal system. Section seventeen: renal replacement / Eleanor Fitzpatrick<br/>Continuous renal replacement therapies / Sonia M. Astle ; Hemodialysis / Sonia M. Astle ; Peritoneal dialysis / Sonia M. Astle<br/>Unit VI: hematologic system. Section eighteen: fluid management / Eleanor Fitzpatrick<br/>Use of a massive infusion device and a pressure infuser bag / Coleen Dever<br/>Section nineteen: special hematologic procedures / Eleanor Fitzpatrick<br/>Apheresis and therapeutic plasma exchange (assist) / Sonia M. Astle ; Bone marrow biopsy and aspiration (perform) / Glen Peterson, Carrie Marvill ; Bone marrow biopsy and aspiration (assist) / Glen Peterson, Carrie Marvill<br/>Unit VII: integumentary system. Section twenty: burn wound management / Mary Beth Flynn Makic<br/>Burn wound care / Cameron Bell ; Donor-site care / Cameron Bell ; Skin graft care / Dawn Sculco<br/>Section twenty-one: special integumentary procedures / Mary Beth Flynn Makic<br/>Intracompartmental pressure monitoring / Julia E. Dunning ; Suture and staple removal / Brian D. Schaad ; Wound closure / Joanna C. Eillis<br/>Section twenty-two: wound management / Mary Beth Flynn Makic<br/>Cleaning, irrigating, culturing, and dressing an open wound / Marylou V. Robinson ; Débridement: pressure ulcers, burns, and wounds / Julie Lynn Henderson ; Drain removal / Brian D. Schaad, Mary Beth Flynn Makic ; Fecal containment devices and bowel management system / Jane V. Arndt ; Negative-pressure wound therapy / Lisa Woods ; Wound management with excessive drainage / Justin Burleson<br/>Unit VIII: nutrition / Eleanor Fitzpatrick. Percutaneous endoscopic gastrostomy (PEG), gastrostomy, and jejunostomy tube care / Margaret M. Ecklund ; Small-bore feeding tube insertion and care / Margaret M. Ecklund ; Small-bore feeding tube insertion using an electromagnetic guidance system (CORTRAK 2 Eternal Access System EAS) / Karen A. Gilbert, Patricia H. Worthington<br/>Unit IX: calculating medication doses / Eleanor Fitzpatrick. Calculating doses, flow rates, and administration of continuous intravenous infusions / Shelley Burcat, Maribeth Kelly.

::Summary## Vol. 1 Contains standards for equipment, decontamination of medica by steam, ethylene oxide, gamma radiation, and electron beam radiation. -- Vol. 2 Contains standards for biomedical equipment. -- Vol. 3 Contains all documents developed under the auspices of the Renal Disease and Detoxification Committee and Hemodialyzer Reuse Submittee.<br/>::Contents##<br/>v. 1. Sterilization<br/>v. 2. Biomedical equipment<br/>v. 3. Dialysis.

::Summary## "AAOS Comprehensive Orthopaedic Review, 3rd edition offers sweeping coverage of the core of orthopaedic knowledge that spans the spectrum of the orthopaedic specialties. This convenient, comprehensive and user-friendly text combines the specific information you need to prepare for your examination. Study to prepare for your Board Exam! This 3-volume study set is designed to prepare orthopaedic residents for the Orthopaedic In Training Exam (OITE), and the American Board of Orthopaedic Surgery (ABOS) Board Certification examination. Dr. Lieberman and his editorial team of Board-certified orthopaedic surgeons edited and present this thorough text in a concise outline format, giving you ready access to the important facts as a quick bulleted review of the concepts you need to know. Study to retain knowledge! With relevant content developed and updated by over 400 physician contributors and editors, this third edition reinforces what you've learned on your daily rounds and skills labs. Organized by specialty, each of the 149 chapters is loaded with color images, illustrations, tables, and charts to support the material and help you retain the information. Study to achieve proficiency! Pinpoint areas for further study by self-testing with nearly 500 multiple-choice companion study questions. Each question includes the preferred response with additional discussion and explanation of the topics. This set is your ideal exam study prep program"--Provided by publisher.

::Summary## The AAP Healthy Development and Well-Child Support Chart provides pediatric health professionals with a quick and easy-to-use reference on some of the most important areas covered in the pediatric well-child visit.<br/>::Contents##<br/>Intro<br/>What Children Need to Thrive<br/>Promoting Early Brain and Child Development<br/>Developmental Milestones: 1-12 Months<br/>Developmental Milestones: 13-33 Months<br/>Developmental Milestones: 3-6 Years<br/>Social-Emotional Milestones<br/>Social-Emotional Development<br/>Adolescent Development<br/>Behavioral Concerns<br/>Mental Health<br/>Gender Care<br/>Obesity Care<br/>Physical Activity<br/>Sleep<br/>Toxic Stress and Resilience

::Contents##<br/>I. User Guide<br/>II. Parameters to be reported for polysomnography<br/>III. Technical and digital specificatioins<br/>IV. Sleep staging rules<br/>Part 1. Rules for adults<br/>Part 2. Rules for children<br/>Part 3. Rules for infants<br/>V. Arousal rule<br/>VI. Cardiac rules<br/>VII. Movement rules<br/>VIII. Respiratory rules<br/>Part 1. Rules for adults<br/>Part 2. Rules for children<br/>IX. Home sleep apnea testing (HSAT) rules for adults<br/>Part 1: HAST utilizing repiratory flow and/or effort parameters<br/>Part 2: HSAT utilizing peripheral arterial tonometry (PAT)<br/>X. Development process<br/>XI. Procedural notes<br/>XII. Glossary ot terms.

::Contents##<br/>Introduction to abbreviated breast magnetic resonance imaging / Christopher E. Comstock<br/>History of MRI in breast cancer screening / Janice S. Sung and Elizabeth A. Morris<br/>Current clinical evidence on abbreviated breast MRI / Christiane Kuhl<br/>Technical aspects of abbreviated breast MRI : the original approach / Christiane Kuhl<br/>Techniques for performing abbreviated breast MRI / R. Edward Hendrick<br/>Abbreviated breast MR imaging protocols and clinical implementation / Gillian M. Newstead<br/>Interpretation guidelines / Janice S. Sung and Constance D. Lehman<br/>MRI-guided biopsy techniques / Carol H. Lee.

::Summary## This book describes 83 theories of behaviour change, identified by an expert panel of psychologists, sociologists, anthropologists and economists as relevant to designing interventions. For each theory, the book provides a brief summary, a list of its component constructs, a more extended description and a network analysis to show its links with other theories in the book. It considers the role of theory in understanding behaviour change and its application to designing and evaluating interventions.

::Summary## ABC Transporters and Cancer provides invaluable information on the exciting and fast-moving field of cancer research. Here, outstanding and original reviews are presented on a variety of topics. This volume covers ABC transporters and cancer, and is suitable for researchers and students alike.<br/>::Contents##<br/>Apical ABC transporters and cancer chemotherapeutic drug disposition / Selvi Durmus, Jeroen J.M.A. Hendrikx and Alfred H. Schinkel<br/>Regulation of ABC transporters blood-brain barrier: the good, the bad, and the ugly / David S. Miller<br/>Molecular basis of the polyspecificity of p-glycoprotein (ABCB1):recent biochemical and structural studies / Eduardo E. Chufan, Hong-May Sim, and Suresh V. Ambudkar<br/>Lipid regulation of the ABCB1 and ABCG2 multidrug transporters / Csilla Hegedüs, Ágnes Telbisz, Tamás Hegedüs, Balázs Sarkadi and Csilla Özvegy-Laczka<br/>ABC transporters and neuroblastoma / Denise M.T. Yu, Tony Huynh, Alan M. Truong, Michelle Haber and Murray D. Norris<br/>Leukemia and ABC transporters / Yu Fukuda, Shangli Lian and John D. Schuetz<br/>Critical role of ABCG2 in ALA-photodynamic diagnosis and therapy of human brain tumor / Toshihisa Ishikawa, Yoshinaga Kajimoto, Yutaka Inoue, Yoji Ikegami and Toshihiko Kuroiwa<br/>Role of ABC transporters in fluoropyrimidine-based chemotherapy response / Anne T. Nies, Tarek Magdy, Matthias Schwab and Ulrich M. Zanger.

::Summary## Clear and concise, this easy-to-use book offers an introductory course on the language of gene cloning, covering microbial, plant, and mammalian systems. It presents the nuts and bolts of gene cloning in a well-organized and accessible manner. Part I of this book outlines the essentials of biology and genetics relevant to the concept of gene cloning. Part II describes common techniques and approaches of gene cloning, ranging from the basic mechanics of DNA manipulation, vector systems, process transformation, to gene analysis. Part III & IV present application technologies of major impact in agriculture, biomedicine, and related areas. The ABCs of Gene Cloning, Third Edition contains updates including a tutorial chapter on gene-vector construction, methodologies on exome sequencing in finding disease genes, revised topics on gene therapy and whole genome sequencing, new developments for gene targeting and genome editing, as well as the current state of next generation sequencing. With more than 140 illustrations, this new edition provides an invaluable text for students and anyone who have interest in gaining proficiency in reading and speaking the language of gene cloning.<br/>::Contents##<br/>Fundamentals of Genetic Processes<br/>Introductory Concepts<br/>Structures of Nucleic Acids<br/>Structures of Proteins<br/>The Genetic Process<br/>Organization of Genes<br/>Reading The Nucleotide Sequence of a Gene<br/>Techniques and Strategies of Gene Cloning<br/>Enzymes Used in Cloning<br/>Techniques Used in Cloning<br/>Cloning Vectors for Introducing Genes into Host Cells<br/>Transformation<br/>Isolating Genes for Cloning<br/>Impact of Gene Cloning<br/>Improving Tomato Quality by Antisense Rna<br/>Transgenic Crops Engineered with Insecticidal Activity<br/>Transgenic Crops Conferred with Herbicide Resistance<br/>Growth Enhancement in Transgenic Fish<br/>Impact of Gene Cloning<br/>Microbial Production of Recombinant Human Insulin<br/>Finding Disease-Causing Genes<br/>Human Gene Therapy<br/>Gene Targeting<br/>DNA Typing<br/>Transpharmers<br/>Bioreactors for Pharmaceutical Products<br/>Animal Cloning<br/>Human Genome Sequencing<br/>Manipulating Gene Vector Constructs.

::Summary## Covers novel, state-of-the-art strategies in engineering and clinical analysis. Explores approaches for analyzing abdominal imaging, including lung, mediastinum, pleura, liver, kidney and gallbladder. Offers present and future applications as applied to the abdomen and thoracic imaging with the most world-renowned scientists in these fields.<br/>::Contents##<br/>1. Computer-Aided Diagnosis Systems for Acute Renal Transplant Rejection: Challenges and Methodologies / Mahmoud Mostapha, Fahmi Khalifa, Amir Alansary, Ahmed Soliman, Jasjit Suri, and Ayman S. El-Baz<br/>2. Kidney Detection and Segmentation in Contrast-Enhanced Ultrasound 3D Images / Raphael Prevost, Benoit Mory, Remi Cuingnet, Jean-Michel Correas, Laurent D. Cohen, and Roberto Ardon<br/>3. Renal Cortex Segmentation on Computed Tomography / Xinjian Chen, Dehui Xiang, Wei Ju, Heming Zhao, and Jianhua Yao<br/>4. Diffuse Fatty Liver Disease: From Diagnosis to Quantification / Luís Curvo-Semedo, Daniel Ramos Andrade, Catarina Ruivo, Cláudia Paulino, and Filipe Caseiro-Alves<br/>5. Multimodality Approach to Detection and Characterization of Hepatic Hemangiomas / Rajan T. Gupta and Daniele Marin<br/>6. Ultrasound Liver Surface and Textural Characterization for the Detection of Liver Cirrhosis / Ricardo Ribeiro, Rui T. Marinho, Jasjit Suri, and J. Miguel Sanches<br/>7. MR Imaging of Hepatocellular Carcinoma / Dong Ho Lee and Jeong Min Lee<br/>8. Magnetic Resonance Imaging of Adenocarcinoma of the Pancreas / Richard C. Semelka, Luz Adriana Escobar, Najwa Al Ansari, and Charles Thomas Alexander Semelka<br/>9. Quantitative Evaluation of Liver Function Within MR Imaging / Akira Yamada<br/>10. Diffusion-Weighted Imaging of the Liver / Ali Muhi, Tomoaki Ichikawa, and Utaroh Motosugi<br/>11. Shape-Based Liver Segmentation Without Prior Statistical Models / Ahmed Afifi and Toshiya Nakaguchi<br/>12. CT Imaging Characteristics of Hepatocellular Carcinoma / Masahiro Okada and Takamichi Murakami<br/>13. Clinical Applications of Hepatobiliary MR Contrast Agents / Antoine Wadih and Sebastian Feuerlein<br/>14. Fast Object Detection Using Color Features for Colonoscopy Quality Measurements / Jayantha Muthukudage, JungHwan Oh, Ruwan Nawarathna, Wallapak Tavanapong, Johnny Wong, and Piet C. de Groen<br/>15. Colon Surface Registration Using Ricci Flow / Wei Zeng, Rui Shi, Zhengyu Su, and David Xianfeng Gu<br/>16. Efficient Topological Cleaning for Visual Colon Surface Flattening / Wei Zeng, Rui Shi, Zhengyu Su, and David Xianfeng Gu<br/>17. Towards Self-Parameterized Active Contours for Medical Image Segmentation with Emphasis on Abdomen / Eleftheria A. Mylona, Michalis A. Savelonas, and Dimitris Maroulis<br/>18. Bridging the Gap Between Modeling of Tumor Growth and Clinical Imaging / Behnaz Abdollahi, Neal Dunlap, and Hermann B. Frieboes<br/>19. Evaluation of Medical Image Registration by Using High-Accuracy Image Matching Techniques / Zisheng Li and Tsuneya Kurihara<br/>20. Preclinical Visualization of Hypoxia, Proliferation and Glucose Metabolism in Non-small Cell Lung Cancer and Its Metastasis / Xiao-Feng Li and Yuanyuan Ma<br/>21. Thermoacoustic Imaging with VHF Signal Generation: A New Contrast Mechanism for Cancer Imaging Over Large Fields of View / Michael Roggenbuck, Jared Catenacci, Ryan Walker, Eric Hanson, Jiang Hsieh, and S.K. Patch<br/>22. Automated Prostate Cancer Localization with Multiparametric Magnetic Resonance Imaging / Yusuf Artan, Imam Samil Yetik, and Masoom A. Haider<br/>23. Ultrasound-Fluoroscopy Registration for Intraoperative Dynamic Dosimetry in Prostate Brachytherapy / Ehsan Dehghan, Nathanael Kuo, Anton Deguet, Yi Le, Elwood Armour, E. Clif Burdette, Danny Y. Song, Gabor Fichtinger, Jerry L. Prince, and Junghoon Lee<br/>24. Multi-Atlas-Based Segmentation of Pelvic Structures from CT Scans for Planning in Prostate Cancer Radiotherapy / Oscar Acosta, Jason Dowling, Gael Drean, Antoine Simon, Renaud de Crevoisier, and Pascal Haigron<br/>25. Propagating Segmentation of a Single Example to Similar Images: Differential Segmentation of the Prostate in 3-D MRI / Emmanouil Moschidis and James Graham<br/>26. 3D Registration of Whole-Mount Prostate Histology Images to Ex Vivo Magnetic Resonance Images Using Strand-Shaped Fiducials / E. Gibson, M. Gaed, J.A. Gómez, M. Moussa, C. Romagnoli, S. Pautler, J.L. Chin, C. Crukley, G.S. Bauman, A. Fenster, and A.D. Ward<br/>27. Anatomical Landmark Detection / David Liu and S. Kevin Zhou.

::Summary## In this book a team of leading experts come together to provide a comprehensive overview of modern imaging of the abdomen and pelvis, with detailed sections on both gastrointestinal and genitourinary imaging. Each chapter has an identical structure and focuses on a particular organ or organ system, allowing the reader to approach the field one topic at a time. Indications for a variety of imaging techniques and examination protocols are clearly described, and the imaging features of normal anatomy and pathologic entities are depicted in an abundance of high-quality images. Care is taken to consider all recent technical developments and new indications, and the diagnostic performance of different imaging modalities is carefully compared. It is anticipated that this book will come to be regarded as the standard work of reference on abdominal and pelvic radiology.<br/>::Contents##<br/>Section I. Pharynx and esophagus<br/>Section II. Stomach duodenum<br/>Section III. Small bowel excluding duodenum<br/>Section IV. Colon and rectum<br/>Section V. Liver<br/>Section VI. Biliary diseases<br/>Section VII. Pancreas<br/>Section VIII. Spleen<br/>Section IX. Mesentery, omentum, peritoneum abdominal wall<br/>Section X. Retroperitoneum<br/>Section XI. Kidney and renal pelvis<br/>Section XII. Prostrate<br/>Section XIII. Scrotum and penis<br/>Section XIV. Ureter and urethra<br/>Section XV. Ovary and adnexa<br/>Section XVI. Uterus<br/>Section XVII. Vagina and vulva<br/>Section XVIII. Pregnancy.

::Contents##<br/>Abdominal radiography<br/>Gastrointestinal fluoroscopy<br/>Gastric wall thickening/masses<br/>Hollow viscus perforation<br/>Small bowel obstruction<br/>Bowel wall thickening<br/>Imaging of the postoperative bowel<br/>Mesenteric ischemia<br/>Colorectal cancer and screening<br/>Right upper quadrant pain<br/>Right lower quadrant pain<br/>Pancreatitis<br/>Solid pancreatic masses<br/>Cystic pancreatic lesions<br/>Chronic liver disease<br/>Imaging of the cirrhotic liver<br/>Benign focal liver lesions<br/>Cholecystitis<br/>Jaundice<br/>Splenomegaly/splenic lesions<br/>Lymphadenopathy<br/>Urolithiasis<br/>Cystic renal masses<br/>Solid renal lesions<br/>Diffuse renal parenchymal disorders<br/>Urinary tract obstruction<br/>Urothelial lesions<br/>Adrenal gland enlargement and nodules<br/>Prostate imaging<br/>Testicular lesions<br/>Endometrial/junctional zone thickening<br/>Focal uterine lesions<br/>Cystic adnexal lesions<br/>Solid adnexal lesions<br/>Müllerian abnormalities<br/>Pelvic floor disease<br/>Postoperative imaging<br/>Abdominal/pelvic trauma<br/>Pitfalls.

::Contents##<br/>Diagnostic approach to protocoling and interpreting MR studies of the abdomen and pelvis<br/>Liver<br/>Gallbladder and biliary system<br/>Pancreas<br/>Spleen<br/>Gastrointestinal tract<br/>Peritoneal cavity<br/>Adrenal glands<br/>Kidneys<br/>Retroperitoneum and body wall<br/>Bladder and nongender pelvis<br/>Male pelvis<br/>Female urethra and vagina<br/>Uterus and cervix<br/>Adnexa<br/>Maternal conditions in pregnancy<br/>Fetus<br/>Chest<br/>Contrast agents<br/>Magnetic resonance-positron emission tomography (MR-PET).

::Contents##<br/>Classification and principals of treatment<br/>Inflammatory mediators in Intra-abdominal sepsis<br/>Intra-abdominal sepsis and imaging considerations<br/>High-risk patients and prognostic factors for abdominal sepsis<br/>Acute appendicitis: what is the best strategy to treat acute appendicites (both complicated and uncomplicated)?<br/>Acute cholecystitis<br/>Acute cholangitis<br/>Pyogenic liver abscess<br/>Gastroduodenal perforations<br/>Small bowel perforations<br/>Acute colonic diverticulitis<br/>Postoperative peritonitis: etiology, diagnosis, and treatment<br/>Damage control surgery in managing abdominal sepsis (Fausto Catena, Italy)<br/>Ongoing peritonitis<br/>Evolving treatment strategies for severe Clostridium difficile colitis: defining the therapeutic window<br/>Complicated intra-dominal infections: principles of antimicrobial therapy<br/>Antimicrobial armamentarium<br/>Antimicrobial resistance in intra-abdominal infections<br/>The role of Candida in abdominal sepsis<br/>The value and interpretation of microbial specimens in the management of cIAI<br/>Appropriate antimicrobial therapy in critically ill patients<br/>Hemodynamic support<br/>Adjunctive therapies in abdominal sepsis<br/>Impact and management of abdominal compartment syndrome in patients with abdominal sepsis<br/>Thromboprophylaxis in patiens with abdominal sepsis<br/>Nutritional support for abdominal sepsis.

::Contents##<br/>1. Immunosuppression in solid organ transplantation<br/>2. Infection Complications after Abdominal Organ Transplantation<br/>3. National Transplant Network. Donor selection and evaluation criteria<br/>4. The safety of donor<br/>5. Medical disease after abdominal solid organ transplantation and the risk of solid and hematologic malignant tumor after transplantation)<br/>6 Indication and timing<br/>7. The donor procurement<br/>8. Orthotopic liver transplantation<br/>9. Anesthetic and perioperative management for liver transplantation<br/>10 Living donor liver transplantation<br/>11. Hepatic Acute and chronic rejection<br/>12. Postoperative technical complications<br/>13. Percutaneous management of biliary and vascular complications<br/>14. Re-transplantation (Causes, Outcome)<br/>15. Indication and timing<br/>16. The donor procurement: Standard technique for procurement in cadaveric donors<br/>17. Live donor evaluation<br/>18. Living donor nephrectomy<br/>19. Renal Transplantation: Surgical technique<br/>20. The intraoperative and perioperative management of Kidney transplantation<br/>21. Kidney acute and chronic rejection<br/>22. Kidney Transplantation: Post-Operative Technical Complications<br/>23. Indications and timing<br/>24. The donor procurement<br/>25 Transplantation<br/>26 Abdominal wall transplantation and technique<br/>27. Anesthetic and perioperative management for Intestinal transplantation<br/>28. Segmental Living-related Small Bowel Transplantation<br/>29. Intestinal Acute and Chronic rejection<br/>30. Combined Kidney-Liver Transplantation<br/>31. Kidney-pancreas Transplantation.

::Contents##<br/>General<br/>Basic physical and technical principles<br/>Blood vessels : the aorta and its branches, the vena cava and its tributaries<br/>Liver<br/>Porta hepatis<br/>Gallbladder<br/>Pancreas<br/>Stomach, duodenum, and diaphragm<br/>Spleen<br/>Kidneys<br/>Adrenal glands<br/>Bladder, prostate, and uterus<br/>Quick guide<br/>The sono consultant<br/>Documentation.

::Summary## Abdominal Ultrasound for Surgeons provides a comprehensive guide to the use of ultrasonography in surgical practice of abdominal diseases. The content is divided into three major sections focusing on basic principles of ultrasound, ultrasound anatomy and pathology of the abdomen, and employment of ultrasound of the abdomen in surgical practice. A final section is dedicated to the logistics of incorporating ultrasound into a surgical practice. The first section provides an introduction to the principles of ultrasonography focusing on ultrasound physics, equipment, and instrumentation. A detailed approach to the various scanning methods and image interpretation is demonstrated with illustrations, images, and video. The second section focuses on ultrasound anatomy of the abdomen. Each chapter demonstrates the normal and abnormal ultrasound anatomy of specific abdominal organ or organ systems (abdominal wall, liver, pancreas, biliary, stomach, anorectum, retroperitoneum, vascular) with illustrations and images. The current status and technique of endoscopic ultrasound of the upper and lower gastrointestinal tracks is addressed in this section. The third section provides a state-of-the-art review of the status of each major application of abdominal ultrasound in surgery. Topics range from trauma ultrasound and laparoscopic staging to techniques in ultrasound guidance and three-dimensional targeting. This section provides a comprehensive review of the employment of interventional, intraoperative, laparoscopic, transabdominal and endoscopic ultrasound. The fourth and last section addresses the practice aspects of incorporation of ultrasound into a surgical practice. Abdominal Ultrasound for Surgeons will serve as a very useful resource and guide for surgeons and students with little to some experience in ultrasound, including practicing surgeons, surgical fellows, and surgical residents.

::Summary## This book presents different patient-oriented perspectives from surgeons, economic evaluation and management researchers, and business companies active in the healthcare sector, striking a balance between the appropriateness/effectiveness of treatment and efficiency/cost. It does not include technical surgical details, but instead provides the necessary knowledge regarding different groups of patients to help economic and management researchers make accurate evaluations. Although partially based on the specific case of abdominal wall surgery in the Italian health system, the book defines a model that can, with the necessary adaptations, be applied in other national contexts. It also analyzes different reimbursement systems and methods of data collection. This approach supports the evolution form evidence-based medicine (EBM) to the future of real-world data (big data analysis). Further, it highlights the critical issue of "silos" reimbursement, which is the pillar of DRG, and proposes methodology to evaluate the direct and indirect benefit and costs of surgery (for example quality of care, costs incurred in cases of surgical complications due to the use of inappropriate, low-cost material or due to surgical procedure. It is a valuable resource for clinicians, surgeons, policymakers and managers in the field.<br/>::Contents##<br/>PART I: Abdominal wall.- 1 Epidemiology.- 2 Anatomy.- 3 Clusters of patology & interventions.- 4 Unit of wall surgery.- 5 Organization and certification of abdominal wall surgery: the German example, the easter Europe example, the Sweden example, the Spain example.- 6 Organization and certification of abdominal wall surgery: the Eastern Europe example.- 7 Organization and certification of abdominal wall surgery: the Swedish example.- 8 Organization and certification of abdominal wall surgery: the Spanish example.- 9 Devices and biomaterials: from chemistry to certification.- 10 Assistential settings.- 11 Preventing incisional hernias: closure of abdominal wall, follow-up in abdominal surgery.- PART II: Economics.- 12 Economic Evaluation and Health Technology Assessment of Healthcare Programmes.- 13 Comparative Effectiveness in Health Technology Assessment for Medical Devices.- 14 Economic evaluation of abdominal Wall Surgery (cost benefit analysis, cost effectiveness, cost-quality analysis).- 15 Cost Containement: abdominal surgery unit.- 16 The Shouldice experience.- 17 Presurgical hidden costs: imaging, assessment clinic.- 18 Postsurgical hidden costs: neuralgia.- 19 Postsurgical hidden costs: infection.- 20 Reimbursement strategies for medical devices: the case of Abdominal Wall Surgery in Italy.- 21 Economic modelling and Budget Impact Analysis in Abdominal Surgery: the case of mesh.- PART III: Outcome.- 22 How to measure outcome in surgery.- 23 Present and future of EBM.- 24 Registries: monitoring clinical ourcomes.- 25 Registries as a source of information for the purchase of devices.- PART IV: Future perspectives.- 26 Stakeholders opinions.- 27 Evolution of abdominal wall surgery in non developed countries.- 28 How social patterns affect the development of science.- 29 Ferrying to the future.

::Summary## "Easily accessible and clinically focused, Abeloff's Clinical Oncology, 6th Edition, covers recent advances in our understanding of the pathophysiology of cancer, cellular and molecular causes of cancer initiation and progression, new and emerging therapies, current trials, and much more. Masterfully authored by an international team of leading cancer experts, it offers clear, practical coverage of everything from basic science to multidisciplinary collaboration on diagnosis, staging, treatment and follow up"--Publisher's description.<br/>::Contents##<br/>Part I: Science and clincial oncology. Section A: Biology and cancer. Molecular tools in cancer research<br/>Intracellular signaling<br/>The cellular microenvironment and metastases<br/>Control of the cell cycle<br/>The pathophysiology of cancer cell death<br/>Cancer immunology<br/>Stem cells, cell differentiation, and cancer<br/>Vascular and interstitial biology of tumors<br/>Cancer metabolism<br/>Section B: Genesis of cancer. Environmental factors<br/>DNA damage response pathways and cancer<br/>Viruses and human cancer<br/>Genetic factors: hereditary cancer predisposition syndromes<br/>Genetic and epigenetic changes in cancer<br/>Section C: Diagnosis of cancer. Pathology, biomarkers, and molecular diagnostics<br/>Imaging<br/>Section D: Clinical trials. Biostatistics and bioinformatics in clinical trials<br/>Trial design<br/>Structures supporting cancer clinical trials<br/>Oncology and health care policy<br/>Section E: Prevention and early detection. Discovery and characterization of cancer genetic susceptibility alleles<br/>Lifestyle and cancer prevention<br/>Cancer screening and early detection<br/>Nicotine dependence: current treatments and future directions<br/>Section F: Treatment. Cancer pharmacology<br/>Therapeutic targeting of cancer cells: era of molecularly targeted agents<br/>Basics of radiation therapy<br/>Hematopoietic stem cell transplantation<br/>Gene therapy in oncology<br/>Therapeutic antibodies and immunologic conjugates<br/>Complementary and alternative medicine<br/>Part II: Problems common to cancer and therapy<br/>Section A: Hematologic problems and infections. Disorders of blood cell production in clinical oncology<br/>Diagnosis, treatment, and prevention of cancer-related venous thrombosis<br/>Infection in the patient with cancer<br/>Section B: Symptom management. Hypercalcemia<br/>Tumor lysis syndrome<br/>Cancer-related pain<br/>Cancer cachexia<br/>Nausea and vomiting<br/>Section C: Treatment complications. Oral complications<br/>Dermatologic toxicities of anticancer therapy<br/>Cardiovascular effects of cancer therapy<br/>Reproductive complications<br/>Paraneoplastic neurologic syndromes<br/>Neurologic complications<br/>Endocrine complications<br/>Pulmonary complications of anticancer treatment<br/>Section D: post treatment considerations. Rehabilitation of individuals with cancer<br/>Survivorship<br/>Second malignant neoplasms<br/>Caring for patients at the end of life<br/>Section E: Local effects of cancer and its metastasis. Acute abdomen, bowel obstruction, and fistula<br/>Superior vena cava syndrome<br/>Spinal cord compression<br/>Brain metastases and neoplastic meningitis<br/>Bone metastases<br/>Lung metastases<br/>Liver metastases<br/>Malignancy-related effusions<br/>Section F: Special populations. Cancer in the elderly: biology, prevention, and treatment<br/>Special issues in pregnancy<br/>Human immunodeficiency virus (HIV) infection and cancer<br/>Part III: Specific malignancies. Section A: Central nervous system. Cancer of the central nervous system<br/>Section B: Head, neck, and eye. Ocular tumors<br/>Cancer of the head and neck<br/>Section C: Skin. Melanoma<br/>Nonmelanoma skin cancers: basal cell and squamous cell carcinomas<br/>Section D: Endocrine. Cancer of the endocrine system<br/>Section E: Thoracic. Cancer of the lung: non-small cell lung cancer and small cell lung cancer<br/>Diseases of the pleura and mediastinum<br/>Cancer of the esophagus and gastroesophageal junction<br/>Section F: Gastrointestinal. Cancer of the stomach and gastroesophageal junction<br/>Cancer of the small bowel<br/>Colon cancer<br/>Cancer of the rectum<br/>Cancer of the anal canal<br/>Liver and bile duct cancer<br/>Carcinoma of the pancreas<br/>Section G: Genitourinary. Cancer of the kidney<br/>Carcinoma of the bladder<br/>Prostate cancer<br/>Cancer of the penis<br/>Testicular cancer<br/>Section H: Gynecological. Cancers of the cervix, vulva, and vagina<br/>Cancer of the endometrium<br/>Ovaries and fallopian tubes<br/>Gestational trophoblastic disease<br/>Cancer of the breast<br/>Section I: Sarcomas. Sarcomas of bone<br/>Sarcomas of soft tissue<br/>Section J: Cancer of undefined site of origin. Carcinoma of Unknown Primary<br/>Section K: Pediatrics. Pediatric solid tumors<br/>Childhood leukemia<br/>Childhood lymphoma<br/>Section L: Hematological. Acute leukemias in adults<br/>Myelodysplastic syndromes<br/>Myeloproliferative disorders<br/>Chronic myeloid leukemia<br/>Chronic lymphoid leukemias<br/>Hairy cell leukemia<br/>Multiple myeloma and related disorders<br/>Hodgkin's Lymphoma<br/>Non-Hodgkin lymphoma<br/>Cutaneous T-cell lymphoma and cutaneous B-cell lymphoma<br/>Adult T-cell leukemia-lymphoma.

::Contents##<br/>pt. I. Science of clinical oncology<br/>sect. A. Biology and cancer<br/>sect. B. Genesis of cancer<br/>sect. C. Diagnosing cancer<br/>sect. D. Preventing and treating cancer<br/>pt. II. Problems common to cancer and its therapy<br/>sect. A. Hematologic problems and infections<br/>sect. B. Metabolic and paraneoplastic syndromes<br/>sect. C. Local effects of cancer and its metastasis<br/>sect. D. Complications of therapy<br/>sect. E. Special populations<br/>pt. III. Specific malignancies.

::Contents##<br/>I. General topics<br/>Are you ready for your surgical rotation?<br/>Cardiopulmonary resuscitation<br/>How to treat all cardiac dysrhythmias<br/>How to think about shock<br/>Congestive heart failure (CHF) and pulmonary insufficiency<br/>Mechanical ventilation<br/>Why get arterial blood gases?<br/>Fluids, electrolytes, Gatorade, and sweat<br/>Nutritional assessment, parenteral, and enteral nutrition<br/>What does postoperative fever mean?<br/>Surgical wound infection<br/>Priorities in evaluation of the acute abdomen<br/>Surgical infectious disease<br/>Risks of blood-borne disease<br/>Sepsis<br/>Frailty<br/>II. Trauma. Initial assessment<br/>Posttraumatic hemorrhagic shock<br/>Traumatic brain injury<br/>Spinal cord injuries<br/>Penetrating neck trauma<br/>Blunt thoracic trauma<br/>Penetrating thoracic trauma<br/>Blunt abdominal trauma<br/>Penetrating abdominal trauma<br/>Hepatic and biliary trauma<br/>Splenic trauma<br/>Pancreatic and duodenal injury<br/>Trauma to the colon and rectum<br/>Pelvic fractures<br/>Upper urinary tract injuries<br/>Lower urinary tract injury and pelvic trauma<br/>Extremity vascular injuries<br/>Facial lacerations<br/>Maxillofacial trauma<br/>Basic care of hand injuries<br/>Burns<br/>Pediatric trauma<br/>III. Abdominal surgery. Appendicitis<br/>Gallbladder disease<br/>Pancreatic cancer<br/>Acute pancreatitis<br/>Diagnosis and therapy of chronic pancreatitis<br/>Portal hypertension and esophageal varices<br/>Gastroesophageal reflux disease<br/>Esophageal cancer<br/>Acid-peptic ulcer disease<br/>Small bowel obstruction<br/>Intestinal ischemia<br/>Diverticular disease of the colon<br/>Acute large bowel obstruction<br/>Inflammatory bowel disease<br/>Upper gastrointestinal bleeding<br/>Lower gastrointestinal bleeding<br/>Colorectal polyps<br/>Colorectal carcinoma<br/>Anorectal disease<br/>Inguinal hernia<br/>Bariatric surgery<br/>IV. Endocrine surgery. Hyperparathyroidism<br/>Hyperthyroidism<br/>Thyroid nodules and cancer<br/>Surgical hypertension<br/>Adrenal laparoscopic adrenalectomy incidentaloma<br/>V. Breast surgery. Breast masses<br/>Primary therapy for breast cancer<br/>VI. Other cancers. What is cancer?<br/>Melanoma<br/>Non-melanoma skin cancer<br/>Parotid tumors<br/>Neck masses<br/>VII. Vascular surgery. What is atherosclerosis?<br/>Arterial insufficiency<br/>Carotid disease<br/>Abdominal aortic aneurysm<br/>Venous disease<br/>Noninvasive vascular diagnostic laboratory<br/>VIII. Cardiothoracic surgery. Coronary artery disease<br/>Mitral stenosis<br/>Mitral regurgitation<br/>Aortic valvular disease<br/>Thoracic surgery for non-neoplastic disease<br/>Lung cancer<br/>Solitary pulmonary nodule<br/>Dissecting aortic aneurysm<br/>IX. Pediatric surgery. Hypertrophic pyloric stenosis<br/>Intestinal obstruction of neonates and infants<br/>Tracheoesophageal malformations<br/>Tracheoesophageal malformations<br/>Congenital diaphragmatic hernia<br/>Abdominal tumors<br/>Congenital cysts and sinuses of the neck<br/>X. Transplantation. Liver transplantation<br/>Kidney and pancreas transplantation<br/>Heart transplantation<br/>Mechanical circulatory support<br/>Lung transplantation<br/>Penile and scrotal urologic emergencies<br/>Urolithiasis<br/>XI. Urology. Renal cell carcinoma<br/>Bladder cancer<br/>Prostate cancer<br/>Urodynamics and voiding dysfunction<br/>Pediatric urology<br/>XII. Health care. Can health care be reformed?<br/>Ethics in the surgical intensive care unit<br/>Professionalism<br/>Required reading.

::Summary## The natural environment for plants is composed of a complex set of abiotic and biotic stresses; plant responses to these stresses are equally complex. Systems biology allows us to identify regulatory hubs in complex networks. It also examines the molecular "parts" (transcripts, proteins and metabolites) of an organism and attempts to combine them into functional networks or models that effectively describe and predict the dynamic activities of that organism in different environments. This book focuses on research advances regarding plant responses to abiotic stresses, from the physiological level to the molecular level. It highlights new insights gained from the integration of omics datasets and identifies remaining gaps in our knowledge, outlining additional focus areas for future crop improvement research. Plants have evolved a wide range of mechanisms for coping with various abiotic stresses. In many crop plants, the molecular mechanisms involved in a single type of stress tolerance have since been identified; however, in order to arrive at a holistic understanding of major and common events concerning abiotic stresses, the signaling pathways involved must also be elucidated. To date several molecules, like transcription factors and kinases, have been identified as promising candidates that are involved in crosstalk between stress signalling pathways. However, there is a need to better understand the tolerance mechanisms for different abiotic stresses by thoroughly grasping the signalling and sensing mechanisms involved. Accordingly, this book covers a range of topics, including the impacts of different abiotic stresses on plants, the molecular mechanisms leading to tolerance for different abiotic stresses, signaling cascades revealing cross-talk among various abiotic stresses, and elucidation of major candidate molecules that may provide abiotic stress tolerance in plants.<br/>::Contents##<br/>"Omics" : a gateway towards abiotic stress tolerance<br/>Second messengers : central regulators in plant abiotic stress response<br/>Signaling peptides : hidden molecular messengers of abiotic stress perception and response in plants<br/>Reactive oxygen species (ROS) : a way to stress survival in plants<br/>Role of cuticular wax in adaptation to abiotic stress : a molecular perspective<br/>Abiotic stress response in plants : a cis-regulatory perspective<br/>Multifarious role of ROS in halophytes : signaling and defense<br/>Enhancing cold tolerance in horticultural plants using in vitro approaches<br/>Omics-based strategies for improving salt tolerance in Maize (Zea mays L.)<br/>Drought stress tolerance in wheat : omics approaches in understanding and enhancing antioxidant defense<br/>Signalling during cold stress and its interplay with transcriptional regulation<br/>Cross talk between phytohormone signaling pathways under abiotic stress conditions and their metabolic engineering for conferring abiotic stress tolerance.

::Summary## This book introduces the clinical application of ABO-incompatible transplantation. In the first part, it starts with the history, blood group antigen, antibody associated with ABO blood type, pathophysiology and pathology and related knowledge. In the second part, it covers clinical experience sharing of ABO-incompatible of heart, liver, lung and kidney transplantation. It provides a systematic methodologies and protocols. .

::Summary## "Abrahams' and McMinn's Clinical Atlas of Human Anatomy, 8th Edition delivers the straightforward visual guidance you need to perform confidently in all examinations and understand spatial relationships required during your medical training, while also acquiring the practical anatomical knowledge needed for your future clinical career. Respected authority Prof. Peter Abrahams and his team of leading international anatomists and radiologists link a vast collection of clinical images to help you master all the essential correlations between the basic science of anatomy and its clinical practice"--Publisher's description.<br/>::Contents##<br/>Head, neck and brain<br/>Vertebral column and spinal cord<br/>Upper limb<br/>Thorax<br/>Abdomen and pelvis<br/>Lower limb<br/>Lymphatics.

::Summary## "The 'Interventional Radiology' volume of the landmark reference "Abrams' Angiography" has now been expanded and thoroughly revised to reflect dynamic advances in interventional radiology. More than 60 contributors representing a "Who's Who" of the specialty provide comprehensive, step-by-step coverage of all contemporary vascular and nonvascular interventional procedures. Major sections discuss today's equipment and describe interventions for specific disorders of each organ system, as well as for trauma, pediatric diseases, abscess drainage, and miscellaneous disorders. More than 1,100 illustrations complement the text. This edition incorporates an extensive new section on interventional oncologic procedures. The section covers all organ-specific cancers for which interventional therapies are used. Other sections include artervenous malformations, liver diseases, arterial occlusive disease, aneurysms, traumatic arterial injuries, hemorrhage, and venous diseases. It also has full color and an accompanying online site to access the content anytime"--Provided by publisher.

::Summary## "Urodynamics has two basic aims: To reproduce the patient's symptomatic complaints while making key observations. To provide a pathophysiological explanation by correlating the patient's symptoms with the urodynamic findings. These two basic aims are crucial to the purpose of urodynamics - essentially it is a diagnostic test that will aid in the management of patients. The need to make urodynamic observations reflects the fact that the patient's symptoms are important, but they might be somewhat misleading. Most patients with lower urinary tract dysfunction (LUTD) present to their doctor with symptoms. However, lower urinary tract symptoms (LUTS - Table 1) should not simply be taken at face value, since a range of differing mechanisms may result in rather similar symptomatic presentations. The statement "the bladder is an unreliable witness" (1) reflects how symptoms are the starting point, but do not actually identify the ultimate explanation. Since treatment should correct the underlying cause, it is necessary to identify mechanisms, avoiding assumption or prejudice coming from taking symptoms at face value. An excellent example of this is voiding LUTS in men, where the cause on urodynamic testing may prove to be bladder outlet obstruction (BOO) and/or detrusor underactivity (DUA); BOO should respond fully to surgery to relieve obstruction such as transurethral resection of prostate (TURP), while such surgery is potentially not helpful in the second (2). Voiding LUTS in males are of unreliable diagnostic value, and only slow stream and hesitancy show any correlation with the urodynamic findings of BOO (3-5). Even with flow rate assessment, one cannot be sure whether BOO is present [Figure 1.1]. The difficulty of assessing LUTD by symptoms alone is the uncertainty about establishing truly what is going on in the individual describing them"-- Provided by publisher<br/>::Contents##<br/>Basic urodynamics and fundamental issues / Marcus Drake, Andrew Gammie, Laura Thomas, Arturo Garcia, Hashim Hashim<br/>Applied Anatomy and Physiology / Chendrimada Madhu and Marcus Drake<br/>The Physics of Urodynamic Measurements / Andrew Gammie<br/>Patient Assessment / Musaab Yassin, Alan Uren, Nikki Cotterill<br/>Treatments for Lower Urinary Tract Dysfunction / Sharon Yeo, Hashim Hashim<br/>Uroflowmetry / Amit Mevcha, Richard Napier-Hemy<br/>Cystometry and pressure-flow studies / Marcus Drake, Rachel Tindle, Su-Min Lee<br/>Videourodynamics / Marcus Drake, Michelle Ong, Devang Desai, Michel Wyndaele, Mark Woodward, Hashim Hashim<br/>Ambulatory Urodynamics / Julie Ellis-Jones, Wendy Bevan, Dharmesh Kapoor, Marcus Drake<br/>Studies assessing urethral pressures / Dharmesh Kapoor and Marcus Drake<br/>Non-invasive urodynamics / Alison Bray, Christopher Blake, Christopher Harding<br/>Urodynamics in Children / Jonathan S. Ellison, Guy Nicholls, and Mark Woodward<br/>Urodynamics in Women / Wael Agur, Ruben Trochez, Antonin Prouza, George Kasyan, Abdelmageed Abdelrahman<br/>Urodynamics in Men / Arturo García-Mora, Connie Chew, Marcus Drake<br/>Structural changes of the bladder outlet / Michelle Ong, Marcus Drake and Devang Desai<br/>Neurological disease and LUTS / Marcus Drake, Jeremy Nettleton, Mo Belal<br/>Urodynamics in older people / Su-Min Lee, Emily Henderson<br/>Troubleshooting during urodynamics / Laura Thomas, Rachel Tindle, Andrew Gammie<br/>Artefacts in urodynamics / Andrew Gammie<br/>Anorectal Physiology / Laura Thomas and Kathryn McCarthy<br/>Organisation of the Urodynamic Unit / Laura Thomas, Alexandra Bacon, Joanne Sheen and Andrew Gammie<br/>Equipment / Andrew Gammie<br/>Working with limited resources / Andrew Gammie, Laura Thomas, Marcus Drake, Eskinder Solomon<br/>Research evidence on the clinical role of urodynamics / Andrew Gammie, Marcus Drake and Hashim Hashim.

::Summary## For more than 40 years, Auditory Brainstem Responses (ABRs) have been used as a diagnostic tool for hearing disorders and brainstem disorders in the pediatric audiology and neurotology and child neurology. While there are many publications in this field, this new volume will review hearing problems and neurological disorders in babies, infants and children, and discuss important new advances such as ABR figure and threshold changes with infant development. The book will also cover auditory neuropathy, its numerous and new sub-classifications. Readers will be thoroughly briefed on all the new perspectives in interpreting data. Researchers and clinicians will find the text to be a valuable tool in the correct diagnosis of hearing problems and neurological diseases among babies and infants.<br/>::Contents##<br/>Part 1 Introduction<br/>1 History of ABR and EABR<br/>Part 2 ABRs<br/>2 Origins of ABR<br/>3 Gestational development of the human auditory system including the cochlea and the central auditory pathways<br/>4 ABR recording technique and the evaluation of peripheral hearing loss<br/>5 Auditory neuropathy spectrum disorders<br/>6 Normalization and deterioration of ABR configuration in child neurology<br/>7 Hypoxic and Anoxic Brain Damage<br/>8 Only wave I, II of the ABR with residual hearing acuity<br/>9 Auditory agnosia and later cortical deafness in a child over 29 years follow-up<br/>Part 3 Electrically Evoked ABRs (EABRs)<br/>10 Electrically evoked Auditory Brainstem Responses (EABRs), Recording Techniques, Normal (Control) and Abnormal Waveforms of the EABR<br/>11 Inner ear malformation and cochlear nerve deficiency<br/>12 Auditory neuropathy<br/>Part 4 Particular Topics<br/>13 Common Cavity Deformity<br/>14 Galvanic VEMP.

::Summary## A high-yield review for the American Board of Surgery In-Training Exam, this text is a comprehensive review for the American Board of Surgery in-Training Exam. It delivers everything needed to excel on the exam: test-taking tips, high-yield facts, more than 300 multiple-choice questions, clinical pearls, illustrations of key anatomy, and bullet point text. Features: focused exclusively on the ABSITE exam, rather than being a combined ABSITE and board review book; organized by organ system; and valuable as last-minute review or a general framework for preparing for the exam.

::Summary## "High yield review for the American Board of Surgery In-Training Exam"-- Provided by publisher.

::Summary## This book serves as a tool for general psychiatrists, medical students, residents, and fellows looking for a clinically relevant and high-yield overview of addiction psychiatry in preparation for their board exams - or for everyday clinical practice. Written by expert educators in addiction psychiatry, the text is organized by substances misused and populations affected. This book serves as both a primary learning tool for those new to the field, as well as a reference for those working in addiction treatment. Each chapter begins with summaries of high yield clinical pearls, followed by general information including treatment, and then ends with accompanying board-style review questions. The scope includes understanding substances of misuse and substance use disorders (SUDs), how to evaluate, diagnose, and monitor SUDs, how to treat SUDs both pharmacologically and behaviorally, and critical information for specific populations of patients. Absolute Addiction Psychiatry for Clinical Practice and Review is an excellent resource for all medical students, residents, fellows, and professionals taking certification exams in addiction, including those in psychiatry, addiction medicine, emergency medicine, internal medicine, pain medicine, and others. The chapter "Laboratory Testing for Substance Use Disorders" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.<br/>::Contents##<br/>Part I: Introduction, Evaluation, Treatment<br/>Health Services for Addiction Treatment and Levels of Care<br/>Laboratory Testing for Substance Use Disorders<br/>Epidemiology, genetics, and neurobiology of substance use and disorders<br/>Screening, Evaluation and Diagnosis of Substance Use Disorder<br/>Psychosocial Treatment of Substance Use Disorders<br/>Recovery from Addiction: Maintenance and Preventing Relapse<br/>Part II: Addictions and their Treatments<br/>Nicotine<br/>Alcohol<br/>Benzodiazepines and other Sedatives, Hypnotics, and Anxiolytics<br/>Cannabinoids<br/>OPIOIDS<br/>Stimulants: Caffeine, Cocaine, Amphetamine and Other Stimulants<br/>Steroids, Dissociatives, Club Drugs, Inhalants, and Hallucinogens<br/>Behavioral Addiction<br/>Part III: Populations<br/>Adolescents and Students<br/>Women and Pregnancy<br/>Lesbian, Gay, Bisexual, Transgender, Queer or Questioning, Intersex, Asexual or Allied<br/>Underserved Populations<br/>Older Adults<br/>Professionals<br/>Part IV: Other Topics<br/>Co-occurring Medical Disorders<br/>Co-occurring Psychiatric Disorders<br/>Prevention, Public Health, and Public Policy<br/>Ethical and Legal Considerations.

::Summary## This book offers a comprehensive review of allergy and immunology, specifically dedicated as a board review preparation. The book is a collective effort and participation of over 90 well known allergists, immunologists, and rheumatologist who are academician and or practitioners. Chapters are presented in a " Case-Based" format. Each chapter presents 2 cases; each case is followed by multiple choice questions/ answers and discussions. Each chapter also offers a list of specific references used in the text, that will enhance the readers' portfolio of resources. Allergy and Immunology Board Review is a must-have resource for allergy & immunology fellows-in-training and all allergy practitioners as well as any medical provider including residents, medical students and allied health who rotate in allergy divisions.<br/>::Contents##<br/>Innate and Adaptive Immunity<br/>Immune Cells and Functions<br/>HistocompatIbility Antigens (HLA) and Transplantation<br/>Allergic Diseases of the Eye<br/>Allergic Rhinitis<br/>Otitis Media<br/>Asthma<br/>Cough and Allergic Diseases<br/>Hypersensitivity Pneumonitis<br/>Allergic Bronchopulmonary Aspergillosis<br/>Food Allergy<br/>Eosinophilic Disorders<br/>A Case-Based Board Review of Angioedema and Urticaria<br/>Atopic Dermatitis<br/>Allergic Contact Dermatitis<br/>Insect Allergy<br/>Latex Allergy<br/>Drug Allergy<br/>Autoimmunity<br/>Vasculitis<br/>B Cell Deficiency<br/>T Cell Deficiency<br/>Combined Immunodeficiency Disorders<br/>Human Immunodeficiency Virus (HIV) Infection and AIDS<br/>Anaphylaxis<br/>Diagnostic Testing in Allergic Diseases<br/>Antihistamines and Corticosteroids<br/>Bronchodilators<br/>New Asthma Therapeutics<br/>Vaccination<br/>Allergen Immunotherapy.

::Summary## This book presents over 500 breast imaging questions with detailed answers to prepare readers for the Radiology Core Exam. Radiology residents looking for preparation materials to use for the Core Exam are often frustrated with the lack of resources available. This book addresses that lack by providing an informative and invaluable high-yield breast imaging case review book for board review and lifelong learning purposes. Editors and authors have collected numerous high quality breast imaging cases that directly align with each diagnosis the Core Exam has included in their study guide. Cases include modalities from mammogram, ultrasound, and MRI. High quality images are included for each case. The book is structured to follow the layout and topics of the ABR Study Guide, making all material boards-relevant. Within each section, cases are presented with boards-style multiple choice questions and detailed explanations, giving the reader over 500 breast imaging questions to learn from. Cases will include diagnosis, etiology, imaging characteristics, and management. Additional topics related to boards preparation and clinical practice are also addressed, including indications for screening, regulations, physics, and quality/safety. This is an ideal guide for radiology residents preparing for the breast imaging portion of their Radiology Core Examination, and for continued practice and learning for practicing radiologists.<br/>::Contents##<br/>Regulations and Standard of Care<br/>BI-RADS Terminology<br/>Screening Mammogram<br/>Diagnostic Mammogram & US<br/>MRI<br/>Interventional Procedures<br/>Pathology<br/>Male Breast<br/>Implants<br/>Breast Cancer Work up and Surgical Planning<br/>Post surgical Breast<br/>Physics. .

::Summary## This concise review book provides a set of evidence-based and up-to-date study questions that demonstrate knowledge of common neurological diseases. Presented in a case-based format, each chapter includes several questions that are intended for medical students, residents rotating through neurology, and neurologists looking for study sources. Filling a need for a supplemental resource to use when studying for board exams, particularly the NBME and RITE, Absolute Case-Based Neurology serves as an invaluable guide to neurology rotations, tests and daily practice.<br/>::Contents##<br/>Neuroanatomy<br/>Headache<br/>Demyelinating Diseases<br/>Epilepsy<br/>Dementia<br/>Vertigo<br/>Pediatric Neurology<br/>Movement Disorders<br/>Neuromuscular Disorders<br/>Spinal Cord/Cauda Equina<br/>Ischemic Stroke and Hemorrhagic Stroke<br/>Increased Intracranial Pressure (ICP)<br/>Head Trauma<br/>Meningitis and Encephalitis<br/>Toxic and Metabolic encephalopathy<br/>.

::Summary## This book contains the most essential information needed for an epilepsy/ EEG rotation. Chapters are formatted with bullet points and feature clinical pearls. Concise and easy-to-read, this quick reference provides neurology residents, clinical neurophysiology and epilepsy fellows, and other clinicians with the most critical information in epilepsy and EEG in a simplified, yet comprehensive format. Divided into two sections, the book first covers the diagnosis, characteristics, and treatment of epilepsy. The second section focuses on EEG placement, procedures, and patterns in various neurological disorders.<br/>::Contents##<br/>What is not a Seizure?<br/>Seizures and Epilepsy<br/>Treatment of Seizures<br/>Catamenial Epilepsy<br/>Electrode Placement and Montages<br/>Normal EEG<br/>Normal EEG Variants<br/>EEG Artifacts<br/>Activation Procedures<br/>Interictal Abnormal EEG Patterns<br/>Ictal EEG Patterns<br/>Encephalopathies and EEG<br/>Brain Death and EEG.

::Summary## This book provides a comprehensive yet concise review of geriatric psychiatry in preparation for the board exam, or for reference during practice. Written by experts in the field, this text thoroughly reviews over 500 developmental, biological, diagnostic, and treatment questions for board certification. Unlike any other text on the market, this book takes a broader approach to the subject, making it accessible for physicians as well as other clinicians, including nurses, therapists, and social workers. Absolute Geriatric Psychiatry Review is an excellent resource for all clinicians who will care for the mental health of aging patients, including psychiatrists, neurologists, psychologists, therapists, nurses, social workers, nursing home administrators, and all others.<br/>::Contents##<br/>Intro<br/>Preface<br/>Contents<br/>Contributors<br/>Part I: Developmental, Psychological and Social Aspects of Aging<br/>Chapter 1: Life Course: Developmental and Transitional Events<br/>Questions<br/>Answers<br/>Further Reading<br/>Chapter 2: Demography and Epidemiology<br/>Questions<br/>Answers<br/>Further Reading<br/>Chapter 3: Culture and Gender<br/>Questions<br/>Answers<br/>Further Reading<br/>Chapter 4: Family and Community<br/>Questions<br/>Answers<br/>Further Reading<br/>Chapter 5: Ethics and Forensics<br/>Questions<br/>Answers<br/>Further Reading<br/>Chapter 6: Economics and Health Policy<br/>Questions Answers<br/>Further Reading<br/>Part II: Biological Aspects of Aging<br/>Chapter 7: Neuroanatomy and Neuropathology<br/>Questions<br/>Answers<br/>Further Reading<br/>Chapter 8: Biochemistry and Neuropharmacology<br/>Questions<br/>Answers<br/>Further Reading<br/>Chapter 9: Anatomy and Physiology<br/>Questions<br/>Answers<br/>Further Reading<br/>Part III: Psychiatric Diagnosis<br/>Chapter 10: Neurocognitive Disorders<br/>Questions<br/>Answers<br/>Further Reading<br/>Chapter 11: Depressive Disorders and Bipolar and Related Disorders<br/>Questions<br/>Answers<br/>Further Reading<br/>Chapter 12: Sleep-Wake Disorders Questions<br/>Answers<br/>Further Reading<br/>Chapter 13: Schizophrenia and Other Psychotic Disorders<br/>Questions<br/>Answers<br/>Further Reading<br/>Chapter 14: Substance-Related and Addictive Disorders<br/>Questions<br/>Answers<br/>Further Reading<br/>Chapter 15: Anxiety Disorders and Obsessive Compulsive and Related Disorders<br/>Questions<br/>Answers<br/>Further Reading<br/>Chapter 16: Sexuality, Gender Dysphoria, and Paraphilic Disorders<br/>Questions<br/>Answers<br/>Further Reading<br/>Part IV: Diagnostic Methods<br/>Chapter 17: Interviewing and History Taking<br/>Questions<br/>Answers<br/>Further Reading Chapter 18: Mental Status Examination<br/>Questions<br/>Answers<br/>Further Reading<br/>Chapter 19: Functional Assessment<br/>Questions<br/>Answers<br/>Further Reading<br/>Chapter 20: Psychological and Neuropsychological Testing<br/>Questions<br/>Answers<br/>Further Reading<br/>Chapter 21: The Neurological Examination<br/>Questions<br/>Answers<br/>Further Reading<br/>Chapter 22: Clinical Laboratory Testing<br/>Questions<br/>Answers<br/>Further Reading<br/>Chapter 23: Structural and Functional Imaging<br/>Questions<br/>Answers<br/>Further Reading<br/>Part V: Treatments<br/>Chapter 24: Pharmacokinetics and Pharmacodynamics Questions<br/>Answers<br/>Further Reading<br/>Chapter 25: Cytochrome P450<br/>Questions<br/>Answers<br/>Further Reading<br/>Chapter 26: Antidepressants<br/>Questions<br/>Answers<br/>Further Reading<br/>Chapter 27: Mood Stabilizers<br/>Questions<br/>Answers<br/>Further Reading<br/>Chapter 28: Antipsychotics<br/>Questions<br/>Answers<br/>Further Reading<br/>Chapter 29: Anxiolytics<br/>Questions<br/>Answers<br/>Further Reading<br/>Chapter 30: Hypnotics<br/>Questions<br/>Answers<br/>Further Reading<br/>Chapter 31: Cognitive Enhancers<br/>Questions<br/>Answers<br/>Further Reading<br/>Chapter 32: Stimulants<br/>Questions<br/>Answers

::Summary## This concise guide covers the evolution and expanding scope of hospital medicine and the variety of clinical, ethical and administrative situations a Hospitalist encounters. 500 questions on inpatient care, co-management of patients and hospital system management are provided with the goal of assessing clinical and academic competency. Questions feature actual cases with evidence-based solutions. Useful to physicians, house staff and advanced nurse practitioners, this up-to-date referenced learning text encompasses all aspects of hospital care.<br/>::Contents##<br/>Inpatient Care<br/>Consultative and Co-Management<br/>Hospital Systems Management.

::Summary## Written in a succinct question and answer format, this comprehensive resource covers all areas of nephrology and common clinical scenarios. Nearly 1000 questions with detailed answers provide nephrology fellows, practicing nephrologists and clinicians a better understanding of nephrology and aid preparations for nephrology and internal medicine boards. Absolute Nephrology Review features the latest evidence and guidelines while fulfilling a critical need within the nephrology community.<br/>::Contents##<br/>1. Fluids, Electrolytes, and Acid-Base Disorders<br/>2. Disorders of Mineral Metabolism and Nephrolithiasis<br/>3. Acute Kidney Injury<br/>4. Chronic Kidney Disease<br/>5. Glomerular, Tubulointerstitial, and Vascular Diseases<br/>6. Genetic Diseases and Pregnancy<br/>7. Hypertension<br/>8. Renal Pharmacology<br/>9. Hemodialysis<br/>10. Peritoneal Dialysis<br/>11. Transplantation.

::Summary## Written in a succinct question and answer format, this comprehensive book is a resource on all areas of nephrology and common clinical scenarios. The updated volume covers the basic physiology of fluids, electrolytes and acid-base problems, renal disorders and management, chronic kidney disease, hypertension, and other essential subjects. The nearly 1000 detailed questions and answers prepare readers for nephrology and internal medicine boards and provide a better understanding of nephrology as a whole. This new edition of Absolute Nephrology Review features the latest evidence and guidelines needed by nephrology fellows, practicing nephrologists, and clinicians.<br/>::Contents##<br/>Intro<br/>New Nomenclature for Kidney Function and Disease<br/>Preface<br/>Contents<br/>Chapter 1: Fluids, Electrolytes, and Acid-Base Disorders<br/>Sodium and Water Abnormalities<br/>Potassium and Acid-Base Disorders<br/>Chapter 2: Glomerular, Tubulointerstitial, and Vascular Diseases<br/>Chapter 3: Calcium, Phosphorus, and Magnesium Disorders and Kidney Stones<br/>Chapter 4: Chronic Kidney Disease<br/>Chapter 5: Acute Kidney Injury and Critical Care Nephrology<br/>Chapter 6: Hypertension<br/>Chapter 7: Renal Pharmacology<br/>Chapter 8: Genetic Diseases and Pregnancy<br/>Chapter 9: Hemodialysis<br/>Chapter 10: Peritoneal Dialysis<br/>Chapter 11: Transplantation<br/>Index

::Summary## This practical question and answer book covers topics within the field of neurocritical care, including aspects of neurology, neurosurgery, general critical care, and emergency medicine. Each chapter serves as a standalone test, comprised of approximately 100 questions, and closely mimics the tone and scope of the United Council for Neurologic Subspecialties (UCNS) certification exam in neurocritical care. Rationale and discussion are provided in the answers section at the end of each exam. This practical study guide will help prepare critical care fellows and residents from a variety of backgrounds (including internal medicine, neurology, anesthesiology, and emergency medicine) for the UCNS exam.

::Summary## This practical book features more than 1000 questions and answers with illustrations for pediatric neurologists, adult neurologists, general pediatricians and students taking their initial board examination and maintenance of certification. All questions are in multiple choice format and followed by the correct answer with a full explanation and appropriate references. Chapters are sectioned by different topics in pediatric neurology, including Epilepsy, Metabolic Disorders and Movement Disorders and other topics. Timely and thorough, this is a handy and succinct resource.<br/>::Contents##<br/>Autism<br/>Behavior Disorders<br/>Congenital & Genetic Disorders<br/>Demyelinating Disorders<br/>Eating Disorders<br/>Epilepsy<br/>Ethics and Professionalism<br/>Neurodegenerative Disorders<br/>Neuro-metabolic Disorders<br/>Headache<br/>Developmental Disorders<br/>Infections<br/>Mental Retardation<br/>Movement Disorders<br/>Neurological complications of Systemic Diseases<br/>Neuromuscular Disorders<br/>Neuro-Oncology<br/>Neuro-Ophthalmology<br/>Neurophysiology<br/>Sleep Disorders<br/>Spinal Cord Disorders<br/>Static encephalopathy/cerebral palsy/rehabilitation<br/>Toxic Encephalopathy<br/>Traumatic Brain Injury<br/>Vascular.

::Summary## This book provides a concise and up-to-date review of key rheumatology topics along with extensive practice questions to assist in preparing for the American Board of Internal Medicine (ABIM) Rheumatology Certification Exam. Each chapter focuses on a single disease and starts with a short review (primarily tables and figures) to highlight the main points and key issues. The review is followed by 10-20 board-style multiple choice questions with detailed explanations for each topic. The chapters and associated preparation questions are written by established experts from top institutions in the United States. The book concludes with a 50-question practice test reflecting the format used by the ABIM Board Certification Exam. Absolute Rheumatology Review is an essential resource for not only graduate students, residents, and fellows in rheumatology and internal medicine studying for board exams but also rheumatologists, physicians, and related professionals preparing for recertification.<br/>::Contents##<br/>Introduction.-Immunological Basis of Inflammatory Arthritides<br/>Clinical Epidemiology for Rheumatologists<br/>Osteoarthritis<br/>Regional Musculoskeletal Syndromes and the use of MSK Ultrasound<br/>Infectious Arthritis<br/>Rheumatoid Arthritis.-Psoriatic Arthritis<br/>Axial Spondyloarthritis<br/>Systemic Lupus Erythematosus<br/>Sjogren's Syndrome<br/>Systemic Sclerosis (Scleroderma)<br/>Vasculitis<br/>Inflammatory Myopathies<br/>Osteoporosis<br/>Crystal Arthritis.-Autoinflammatory Diseases<br/>Pediatric Rheumatology for Adult Rheumatologists.-Musculoskeletal Manifestations of Systemic Diseases<br/>Clinical Genetics in Rheumatology.

::Contents##<br/>1990. Forging the future, health objectives for the year 2000<br/>1991. Public health and a national health program<br/>1994. Building healthy environments<br/>1995. Decision making in public health<br/>1996. Empowering the disadvantaged, social justice in public health<br/>1997. Communicating public health<br/>1998. Public health and managed care<br/>1999. Celebrating a century of progress in public health<br/>2000. Eliminating health disparities.

::Contents##<br/>1. [Symposia I-III]<br/>2. [Symposia IV-VII]<br/>3. Colloquia I-XIV<br/>4. General sessions A-F<br/>5. General sessions G-J<br/>[6] Author index<br/>[7] Supplement I-

::Summary## "The seventh biennial Harrison Survey, jointly sponsored by the Association of American Medical Colleges (AAMC) and the Society for Academic Continuing Medical Education (SACME), documents an academic enterprise that displays three major characteristics, somewhat in opposition to its traditional image as an isolated, passive educational entity. First, continuing medical education/ continuing professional development (CME/CPD) is increasingly integrated into the functions and missions of academic medical centers, academic health systems, and medical schools of the United States and Canada. Second, it demonstrates numerous examples of innovation and scholarship in educational design and operation. Finally, possibly as a result of the first two elements, there is an increased focus on assessing the impact of CME/CPD activities on learner competence, performance, and health care outcomes. The purpose of the survey is to help identify and understand the placement and alignment of the CME/CPD unit within the academic medical center (AMC). Survey findings will benefit those in the CME/CPD field who can use the data to assess and enhance the shape and scope of CME/CPD and who will share the information with AMC leaders, including deans, CEOs, and others. The survey generates broad but important findings for discussion and analysis in three areas: CME/CPD's structure, its function relative to relationships and educational methods, and its scope, reach, and impact. Throughout this report, data from the last Harrison Survey in 2013 are used for comparative purposes"--Executive summary.<br/>::Contents##<br/>Executive summary<br/>Background and methods<br/>Section 1: Survey response rate and responder characteristics<br/>Section 2: Structural elements of CME/CPD in the academic medical center<br/>Section 3: Function of academic CME/CPD in the health care system<br/>Section 4: Reach, scope, and impact of CME/CPD programming<br/>Section 5: Discussion: structure, function, impact, and direction of academic CME.

::Contents##<br/>Part 1. General Considerations<br/>1. Global Burden of Surgical Disease and the Role of Academia<br/>2. Promoting, Developing, and Sustaining Academic Global Surgery Programs.-3. Ethics in Global Surgery<br/>Part 2. Career<br/>4. Preparing and Sustaining Your Career in Academic Global Surgery<br/>5. Balancing Global Surgery with Traditional Career and Life Demands<br/>Part 3. Clinical<br/>6. Guidelines and Parameters for Ideal Short-Term Interactions: Disaster Relief<br/>7. How to Set Up for an Ideal Long Term Clinical Interaction<br/>Part 4. Research<br/>8. Current Research Needs and Priorities<br/>9. Research Methods Appropriate and Applicable to Global Surgery<br/>10. Funding for Global Surgical Programs<br/>Part 5. Education<br/>11. Developing Educational Opportunities for Trainees on Both Sides<br/>12. The Role of Educational Research in the Global Setting<br/>Part 6. Resources<br/>13. Tools Useful for the Academic Global Surgeon.

::Contents##<br/>Part I. What You Should Know Before You Start<br/> 1. The Structure of Academic Careers<br/> 2. Hiring from the Institution's Point of View<br/> Part II. Planning and Timing Your Search<br/> 3. Becoming a Job Candidate: The Timetable for Your Search<br/> 4. Deciding Where and When to Apply<br/>5. Building an Academic Network<br/> 6. Letters of Recommendation<br/>7. Learning About Openings<br/> Part III. Written Materials for the Job Search: Suggestions and Samples<br/> 8. Responding to Position Announcements<br/> 9. CVs<br/> 10. Additional Application Materials<br/> 11. Online Presence<br/>12. Job Hunting Correspondence<br/> IV. Conducting the Search<br/>13. Interviewing<br/>14. Preliminary Interviews<br/>15. The Campus Visit<br/>16. Job Offers, Negotiations, Acceptances, and Rejections<br/> Part V. After You Take the Job<br/>17. Starting the Job<br/>18. Knowing About and Getting Tenure<br/>19. Changing Jobs<br/> Part VI. Additional Considerations<br/>20. Dual-Career Couples and Pregnant on the Job Market<br/> 21. International Job Search<br/> 22. Cultural and Experiential Diversity<br/>Part VII. Beyond Faculty Careers<br/>23. Exploring the Expanded Job Market<br/> Appendices<br/> Appendix 1: National Job Listing Sources and Scholarly and Professional Associations<br/>Appendix 2: Additional Resources<br/> Appendix 3: Sample Application Package<br/>Index<br/> Comments.

::Summary## Attaining professional success and finding personal happiness in academic medicine is not an easy path, yet both are critical if the future is to be brighter through better science, better clinical care, better training, better responsiveness to communities, and better stewardship and leadership in the health professions. This concise, easy to read title consists of "mini" chapters intended as a resource to assist early- and middle-career physicians, clinicians, and scientists in understanding the unique mission of academic medicine and building creative, effective, and inspiring careers in a challenging field.<br/>::Contents##<br/>Part I: Approaching the Profession of Academic Medicine<br/>How to Find Your Path in Academic Medicine<br/>How to Build the Foundation for a Successful Career in Academia<br/>How to Be Organized and Manage Time<br/>How to Align Individual Goals with Institutional Goals<br/>Part II: Getting Established<br/>How to Prepare the Best Possible Curriculum Vitae<br/>How to Interview for a First Academic Position<br/>How to Evaluate a Letter of Offer or Contract<br/>How to Give a Lecture<br/>How to Build Assessments for Clinical Learners<br/>How to Approach Clinical Supervision<br/>How to Evaluate and Give Feedback<br/>How to Teach in Busy Clinical Settings<br/>How to Write Effective Letters of Recommendation<br/>How to Teach Creatively<br/>How to Use Technology in Educational Innovation<br/>How to Maintain Excellent Clinical Documentation<br/>How to Avoid Medicolegal Problems<br/>Part III: Approaching Work with Colleagues<br/>How to Network and Be a Good Colleague<br/>How to Collaborate Interprofessionally<br/>How to Approach Mentorship as a Mentee<br/>How to Be a Good Mentor<br/>How to Participate in Institutional Review Board Activities<br/>How to Participate in Ethics Committees<br/>How to Intervene with Unethical and Unprofessional Colleagues<br/>Part IV: Writing and Evaluating Manuscripts<br/>How to Write and Publish an Empirical Report<br/>How to Write a Case Report<br/>How to Review a Manuscript<br/>How to Evaluate Biomedical Research Publications Rigorously<br/>How to Understand Flaws in Clinical Research<br/>Part V: Conducting Empirical Research<br/>How to Conceptualize a Research Project<br/>How to Prepare an IRB Application<br/>How to Engage Communities in Research<br/>How to Approach a First Grant Application<br/>How to Fund Your Research While Maintaining Your Curiosity<br/>How to Review Grant Applications<br/>How to Prepare a Poster<br/>How to Prepare and Give a Scholarly Oral Presentation<br/>Part VI: Developing Administrative Skills<br/>How to Be an Effective Team Leader and Committee Member or Chair<br/>How to Negotiate<br/>How to Think About Money in Academic Settings<br/>How to Engage in Departmental Strategic Planning<br/>How to Read a Basic Budget<br/>How to Strengthen Your Own and Others' Morale<br/>Part VII: Advancing Your Academic Career<br/>How to Create Your Package for Promotion<br/>How to Understand Promotion Criteria for "Traditional" and "Research" Tracks<br/>How to Understand Promotion Criteria for "Clinician Educator" and "Teaching" Tracks<br/>How to Develop an Educator's Portfolio<br/>How to Build a National Reputation for Academic Promotion<br/>How to Recognize and Address Unconscious Bias<br/>How to Address Challenges and Opportunities as an International Medical Graduate<br/>How to "Pitch" a Nontraditional Career Path<br/>Part VIII: Balancing Professional and Personal Life<br/>How to Have a Healthy Life Balance as an Academic Physician<br/>How to Care for the Basics: Sleep, Nutrition, Exercise, Health<br/>How to Recognize and Avoid Burnout<br/>How to Manage Personal Finances<br/>How to Develop Professional Relationships.

::Summary## This comprehensive text is the definitive academic pain medicine resource for medical students, residents and fellows. Acting as both an introduction and continued reference for various levels of training, this guide provides practitioners with up-to-date academic standards. In order to comprehensively meet the need for such a contemporary text--treatment options, types of pain management, and variables affecting specific conditions are thoroughly examined across 48 chapters. Categories of pain conditions include orofacial, neuropathic, visceral, neck, acute, muscle and myofascial, chronic urogenital and pelvic, acute, and regional. Written by renowned experts in the field, each chapter is supplemented with high-quality color figures, tables and images that provide the reader with a fully immersive educational experience. Academic Pain Medicine: A Practical Guide to Rotations, Fellowship, and Beyond is an unprecedented contribution to the literature that addresses the wide-spread requisite for a practical guide to pain medicine within the academic environment.

::Summary## This volume deals with philosophically grounded theories of animal generation as found in two different traditions: one, deriving primarily from Aristotelian natural philosophy and specifically from his Generation of Animals; and another, deriving from two related medical traditions, the Hippocratic and the Galenic. The book contains a classification and critique of works that touch on the history of embryology and animal generation written before 1980. It also contains translations of key sections of the works on which it is focused. It looks at two different scholarly communities: the physicians (medici) and philosophers (philosophi), that share a set of textual resources and philosophical lineages, as well as a shared problem (explaining animal generation), but that nevertheless have different concerns and commitments. The book demonstrates how those working in these two traditions not only shared a common philosophical background in the arts curricula of the universities, but were in constant intercourse with each other.0This book presents a test case of how scholarly communities differentiate themselves from each other through methods of argument, empirical investigation, and textual interpretations. It is all the more interesting because the two communities under investigation have so much in common and yet, in the end, are distinct in a number of important ways.

::Summary## Accelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of advanced modeling technologies, from target identification and validation to nonclinical studies in animals to Phase 1-3 human clinical trials and post-approval monitoring, as alternative models of drug development. As a case of successful integration of computational modeling and drug development, we discuss the development of oral small molecule therapeutics for inflammatory bowel disease, from the application of docking studies to screening new chemical entities to the development of next-generation in silico human clinical trials from large-scale clinical data. Additionally, this book illustrates how modeling techniques, machine learning, and informatics can be utilized effectively at each stage of drug development to advance the progress towards predictive, preventive, personalized, precision medicine, and thus provide a successful framework for Path to Cures.<br/>::Contents##<br/>Intro; Contents; Contributors<br/>Chapter 1: Introduction to Accelerated Path to Cures and Precision Medicine in Inflammatory Bowel Disease; Overview; LANCL2 Drug Development Use Case; Network Modeling for PD Biomarker Analyses Use Case; References<br/>Chapter 2: Computer-Aided Drug Discovery; Overview; Structure-Based Versus Ligand-Based Modeling; Ligand-Based Modeling Approaches; Similarity Searching; Ligand-Based Pharmacophore Modeling; Quantitative-Structure Activity Relationship Modeling (QSAR); Structure-Based Modeling Approaches; Molecular Docking; Structure-Based Pharmacophore Modeling. Accelerating the Path to Precision MedicineComputational Models Used for Precision Medicine Discovery Measures Endpoints of Immune Mediated and Inflammatory Diseases; Concluding Remarks; References<br/>Chapter 5: Development of Synthetic Patient Populations and In Silico Clinical Trials; Overview; Clinical Research and Clinical Trials; Design Strategies; Data Sources; Predictive Modeling for Precision Medicine; Data-Driven Models; Mechanistic Models; Rule-Based Models; Human Avatars: Virtual Patient Populations; Treatment Design; Data-Driven Design; Mechanistic Modeling-Based Design. Citrobacter rodentium Infection Model of Colitis MDR1a -/- Model of Colitis; Pig as Model of Colitis; Cell-Specific Knockout Mice; Animal Models Used in Drug Development for IBD; Utilization of Computational Models in Preclinical Studies; Concluding Remarks; References; Chapter 4: From Nutritional Immunology to Drug Development; Overview; Nutritional Modulation of Immune-Mediated Diseases; Important Immunometabolic Pathways; Nutrition-Based Therapeutics Used to Treat Gastrointestinal Diseases; Computational Approaches to Discover New Therapeutics: A Precision Medicine Initiative Molecular Docking and Virtual Screening Molecular Docking; Virtual Screening; Application of Molecular Dynamics Simulations in Drug Discovery; General Considerations; Applications of Molecular Dynamics in Generating Conformational Ensembles; MD and Scoring; MD to Discover Novel Binding Sites; Success Stories in Computational Drug Discovery; Concluding Remarks; References<br/>Chapter 3: Preclinical Studies: Efficacy and Safety; Preclinical Studies: Safety; Preclinical Studies: Efficacy; Animal Models of IBD to Test Therapeutic Efficacy; DSS-Induced Colitis; Adoptive Transfer Model of Colitis. Statistical Analysis Dimensionality Reduction; Analysis of Variance; Concluding Remarks; References; Index.

::Contents##<br/>1. Accelerated predictive stability: an introduction<br/>2. Regulatory expectations and industry practice on stability testing<br/>3. Theory and fundamentals of accelerated predictive stability (APS) studies<br/>4. Practical considerations<br/>5. The humidity exposure of packaged products<br/>6. Data evaluation and statistical methods<br/>7. Strategies for improving the reliability of accelerated predictive stability (APS) studies<br/>8. Integration of APS into a rapid, early clinical drug product development paradigm<br/>9. Accelerated predictive stability (APS) regulatory strategies<br/>10. Embedding APS within business<br/>11. Implementing an accelerated predictive stability program<br/>12. Accelerated stability assessment program (ASAP) applications in a postapproval environment<br/>13. ASAP application: unstable drug candidate in early development<br/>14. ASAP application in suspension, liquid, lyophilized, and controlled-release drug products<br/>15. Applications of ASAP to generic drugs<br/>16. ASAP application: nicotine lozenges<br/>17. ASAP applications in clinical development: prediction of degradation and dissolution performance<br/>18. Accelerated predictive stability (APS) applications: packaging strategies for controlling dissolution performance<br/>19. Accelerated stability modeling: investigation of disintegration time of a drug product with sodium bicarbonate<br/>20. Accelerated stability modeling: an ionic liquid drug product<br/>21. Accelerated stability modeling: assay loss of nicotine lozenges<br/>22. Accelerated stability modeling: desolvation of a solvate drug product.

::Summary## "Beyond simulation and algorithm development, many developers increasingly use MATLAB even for product deployment in computationally heavy fields. This often demands that MATLAB codes run faster by leveraging the distributed parallelism of Graphics Processing Units (GPUs). While MATLAB successfully provides high-level functions as a simulation tool for rapid prototyping, the underlying details and knowledge needed for utilizing GPUs make MATLAB users hesitate to step into it. Accelerating MATLAB with GPUs offers a primer on bridging this gap. Starting with the basics, setting up MATLAB for CUDA (in Windows, Linux and Mac OS X) and profiling, it then guides users through advanced topics such as CUDA libraries. The authors share their experience developing algorithms using MATLAB, C++ and GPUs for huge datasets, modifying MATLAB codes to better utilize the computational power of GPUs, and integrating them into commercial software products. Throughout the book, they demonstrate many example codes that can be used as templates of C-MEX and CUDA codes for readers' projects. Download example codes from the publisher's website: http://booksite.elsevier.com/9780124080805/ Shows how to accelerate MATLAB codes through the GPU for parallel processing, with minimal hardware knowledge -- Explains the related background on hardware, architecture and programming for ease of use -- Provides simple worked examples of MATLAB and CUDA C codes as well as templates that can be reused in real-world projects."--Provided by publisher.<br/>::Contents##<br/>Accelerating MATLAB without GPU<br/>Configurations for MATLAB and CUDA<br/>Optimization planning through profiling<br/>CUDA coding with c-mex<br/>MATLAB and parallel computing toolbox<br/>Using CUDA-accelerated libraries<br/>Example in computer graphics<br/>CUDA conversion example : 3D image processing.

::Contents##<br/>Introduction to mindfulness and acceptance-based therapies for psychosis / Joseph E. Oliver, Candice Joseph, Majella Byrne, Louise C. Johns and Eric M.J. Morris<br/>Theory on voices / Fran Shawyer, Neil Thomas, Eric M.J. Morris and John Farhall<br/>Emotional processing and metacognitive awareness / Claire Hepworth, Helen Startup and Daniel Freeman<br/>Clinical assessment and assessment measures / John Farhall, Fran Shawyer, Neil Thomas and Eric M.J. Morris<br/>Acceptance and commitment therapy case formulation / Patty Bach<br/>Engaging people with psychosis in acceptance and commitment therapy and mindfulness / Brandon A. Gaudiano and Andrew M. Busch<br/>Acceptance and commitment therapy for voices / Neil Thomas, Eric M.J. Morris, Fran Shawyer and John Farhall<br/>Acceptance and commitment therapy for delusions / José Manuel García Montes, Marino Pérez Álvarez and Salvador Perona Garcelán<br/>Acceptance and commitment therapy for emotional dysfunction following psychosis / Ross White<br/>Person-based cognitive therapy for distressing psychosis / Lyn Ellett<br/>Spirituality: a new way into understanding psychosis / Isabel Clarke<br/>The service user experience of acceptance and commitment therapy and person-based cognitive therapy / Joseph E. Oliver, Mark Hayward, Helena B. McGuiness<br/>Acceptance and commitment therapy for first-episode psychosis / Joseph E. Oliver and Eric M.J. Morris<br/>Acceptance and commitment therapy for psychosis in acute psychiatric admission settings / Gordon Mitchell and Amy McArthur<br/>Developing acceptance and commitment therapy for psychosis as a group-based intervention / Amy McArthur, Gordon Mitchell and Louise C. Johns<br/>Group person-based cognitive therapy for distressing psychosis / Clara Strauss and Mark Hayward<br/>Appendix A: chessboard metaphor<br/>Appendix B: leaves-on-the-stream metaphor<br/>Appendix C: passengers-on-the-bus metaphor<br/>Appendix D: person-in-the-hole metaphor<br/>Appendix E: polygraph metaphor<br/>Appendix F: see the wood for the trees (and other helpful advice for living life)<br/>Appendix G: skiing metaphor<br/>Appendix H: tug-of-war-with-the-monster metaphor.

::Contents##<br/>The history of the treatment of mental illness<br/>Acceptance and the recovery paradigm in mental health care<br/>The multiple dimensions of the acceptance of mental illness<br/>Barriers and facilitators to acceptance of mental illness<br/>The process of acceptance of mental illness<br/>Acceptance of mental illness among women : intersectional stigma<br/>Acceptance of mental illness among men : exploring masculinities and mental health<br/>Racial-ethnic cultural factors in the process of acceptance of mental illness<br/>LGBT factors in the process of acceptance of mental illness<br/>Clinical applications and investigation of the acceptance of mental illness.

::Summary## "The use of venous access devices (VADs) is central to the care that nurses provide to patients with cancer. Oncology nurses must base their practice on evidence-based research when available, but a lack of evidence has been a professional challenge for decades. With limited research to guide practice, ongoing controversies remain regarding optimal device management. Since 1989, the Oncology Nursing Society (ONS) has provided guidelines to establish a foundation for access device management. With this new text, ONS has identified practice standards, developed from a synthesis of evidence, critical review, and analysis of aspects of access device management for which nursing is accountable. Access Device Standards of Practice for Oncology Nursing reviews the controversies in access device care, explores the range of devices currently available, details the advantages and disadvantages of each device to ensure optimal selection based on patient needs, and discusses the key legal ramifications concerning access devices and their management. With access device technology becoming more complex, this text is an essential resource for nurses practicing in a wide range of settings to ensure safe, effective care of patients with VADs."--Publisher's description.<br/>::Contents##<br/>Access device standards, recommendations, and controversies<br/>Short-term peripheral intravenous catheters<br/>Midline catheters<br/>Nontunneled central venous lines<br/>Peripherally inserted central catheters<br/>Tunneled central venous catheters<br/>Implanted venous ports<br/>Apheresis catheters<br/>Complications of long-term venous access devices<br/>Subcutaneous infusion devices<br/>Arterial access devices<br/>Intraventricular access devices<br/>Epidural and intrathecal access devices<br/>Intraperitoneal catheters<br/>Pleural catheters<br/>Ambulatory infusion pumps<br/>Education, documentation, and legal issues for access devices.

::Summary## This salient volume surveys the state of access to primary care and preventive health services by migrants, refugees, and asylum seekers across Europe. Experts in public health and allied fields identify obstacles to healthcare interventions for migrants, including costs, legal status, health-related behaviors and beliefs, and cultural and language barriers. The book includes the latest data concerning access to specific preventive services (e.g., vaccinations, colorectal screenings), specific issues of women and sexual minorities, and the potential for health promotion in prevention. Best practices for improving access are outlined as a basis for public health and policy directives toward reducing health disparities between migrant and native populations. Among the topics covered: Access to medical examination for prevention among migrants Access and barriers to infant vaccinations, female cancer screening and colorectal screening among migrant populations Provision and policy gap between the primary and preventive care required by and the care provided to LGBTQ+ migrants, refugees, and asylum seekers. Health related lifestyles and intermediate health conditions of migrants. Quality of primary healthcare and preventive health services provided to migrants Adaptations of primary health care for migrants Access to primary health care and policies on migration and health at a time of economic crisis Dedicated to bridging research and policy gaps in this vital area, Primary Care Access and Preventive Health Services of Migrants is intended for an international audience of academics, researchers, policymakers, and practitioners in public health and related disciplines. -- Publisher description.<br/>::Contents##<br/>1. Foreword<br/>2. Rights to primary care access and health prevention of non-nationals and migrants in the European Union Countries (Nadia Mignolli, Alessandra Fasano, Roberta Pace)<br/>3. Access and barriers to childhood immunization among migrant populations (Pierluigi Lopalco)<br/>4. Access to medical examination for primary prevention among migrants (Alessio Petrelli, Anteo Di Napoli, Alessandra Rossi)<br/>5. Avoidable hospitalization among migrants and ethnic minorities in western countries (Laura Cacciani, Nera Agabiti, Teresa Dalla Zuanna, Cristina Canova)<br/>6. Female migrants' attitudes and access to cervical and breast cancer screening in Europe (Sandra Buttigieg)<br/>7. Access to colorectal screening (Aldo Rosano)<br/>8. Health-related lifestyles among migrants (Teresa Spadea, Raffaella Rusciani, Luisa Mondo, Giuseppe Costa)<br/>9. Adaptation of primary health care for migrants: recommendations and best practices (Marie Dauvrin, Bernadett Varga)<br/>10. Health policies, patterns, and barriers to migrants' access to primary health care (Sonia Dias, Inés Fronteira , Ana Gama, J Coloma, Jorge Simões, Henrique Barros)<br/>11. Access to primary care and preventive health services of LGBTQ+ migrants, refugees, and asylum seekers (J Namer, O Razum)<br/>12. Concluding Remarks.

::Summary## "AccessDermatologyDxRx is a comprehensive resource for all physicians and other healthcare providers including medical students, dermatology residents, internists, oncologists, and infectious disease specialists. With thousands of images that include all of the essential information to help you with clinical decision-making, this resource covers the full scope of dermatologic conditions."--Website.

::Summary## Clinical cases selected from the LANGE Case Files series, edited by Eugene C. Toy, MD.<br/>::Contents##<br/>Basic science:<br/>Anatomy<br/>Biochemistry<br/>Microbiology<br/>Neuroscience<br/>Pathology<br/>Pharmacology<br/>Physiology. Clinical medicine:<br/>Anesthesiology<br/>Emergency Medicine<br/>Family Medicine<br/>Internal Medicine<br/>Neurology<br/>Ob/Gyn<br/>Pediatrics<br/>Psychiatry<br/>Surgery.

::Summary## "AccessPediatrics from McGraw-Hill Medical covers the entire span of pediatric practice, from neonatology through adolescent medicine. Updated regularly and optimized for viewing on any device, this comprehensive online pediatric resource provides instant access to information essential for completing evaluation, diagnosis, and case management decisions, as well as for pursuing research or self-assessment and board review -- all in one place."--Website.

::Summary## "AccessPediatrics from McGraw-Hill Medical covers the entire span of pediatric practice, from neonatology through adolescent medicine. Updated regularly and optimized for viewing on any device, this comprehensive online pediatric resource provides instant access to information essential for completing evaluation, diagnosis, and case management decisions, as well as for pursuing research or self-assessment and board review -- all in one place."--Website.

::Summary## Interactive self-assessment section of AccessSurgery website. Allows users to create and take custom tests based on standard review texts.

::Summary## Since it was first published, Accident and Emergency Radiology: A Survival Guide has become the classic in-my-pocket-reference and an indispensable aid to all those who work in the Emergency Department. The core and substantial value lies in the step-by-step analytical approaches which help you to answer this question: "These images look normal to me, but . . . how can I be sure that I am not missing a subtle but important abnormality?" Ensure accuracy in reading and interpretation of any given image. Common sources of error and diagnostic difficulty are highlighted. Prevent mistakes. Pitfalls and associated abnormalities are emphasized throughout. Avoid misdiagnoses. Normal anatomy is outlined alongside schemes for detecting variants of the norm. Each chapter concludes with a summary of key points. Will provide a useful overview of the most important features in diagnosis and interpretation.Easily grasp difficult anatomical concepts. Radiographs accompanied by clear, explanatory line-drawings.<br/>::Contents##<br/>1. Key principles<br/>2. Particular paediatric points<br/>3. Paediatric skull-suspected NAI<br/>4. Adult skull<br/>5. Face<br/>6. Shoulder<br/>7. Paediatric elbow<br/>8. Adult elbow<br/>9. Wrist & distal forearm<br/>10. Hand & fingers<br/>11. Cervical spine<br/>12. Thoracic & lumbar spine<br/>13. Pelvis<br/>14. Hip & proximal femur<br/>15. Knee<br/>16. Ankle & hindfoot<br/>17. Midfoot & forefoot<br/>18. Chest<br/>19. Abdominal pain & abdominal trauma<br/>20. Penetrating foreign bodies<br/>21. Swallowed foreign bodies<br/>22. Test yourself<br/>Test Yourself-answers.

::Summary## This book provides a state-of-the-art look at the applied biomechanics of accidental injury and prevention. The editors, Drs. Narayan Yoganandan, Alan M. Nahum and John W. Melvin are recognized international leaders and researchers in injury biomechanics, prevention and trauma medicine. They have assembled renowned researchers as authors for 29 chapters to cover individual aspects of human injury assessment and prevention. This third edition is thoroughly revised and expanded with new chapters in different fields. Topics covered address automotive, aviation, military and other environments. Field data collection; injury coding/scaling; injury epidemiology; mechanisms of injury; human tolerance to injury; simulations using experimental, complex computational models (finite element modeling) and statistical processes; anthropomorphic test device design, development and validation for crashworthiness applications in topics cited above; and current regulations are covered. Risk functions and injury criteria for various body regions are included. Adult and pediatric populations are addressed. The exhaustive list of references in many areas along with the latest developments is valuable to all those involved or intend to pursue this important topic on human injury biomechanics and prevention. The expanded edition will interest a variety of scholars and professionals including physicians, biomedical researchers in many disciplines, basic scientists, attorneys and jurists involved in accidental injury cases, and governmental bodies. It is hoped that this book will foster multidisciplinary collaborations by medical and engineering researchers, and academicians and practicing physicians for injury assessment and prevention and stimulate more applied research, education and training in the field of accidental-injury causation and prevention.<br/>::Contents##<br/>Introduction to and applications of injury biomechanics<br/>Automotive field data in injury biomechanics<br/>Medical imaging and injury scaling in trauma biomechanics<br/>Anthropomorphic test devices and injury risk assessments<br/>Restraint system biomechanics<br/>Computational modeling in injury biomechanics<br/>Computational analysis of bone fracture<br/>Skull and facial bone injury biomechanics<br/>Biomechanics of brain injury: a historical perspective<br/>Biomechanics of brain injury: looking to the future<br/>Neck injury biomechanics<br/>Upper extremity biomechanics<br/>Thorax injury biomechanics<br/>Impact and injury response of the abdomen<br/>Thoracic spine injury biomechanics<br/>Lumbar spine injury biomechanics<br/>Knee, thigh, and hip injury biomechanics<br/>Leg, foot, and ankle injury biomechanics<br/>Pain biomechanics<br/>Thoracolumbar pain: neural mechanisms and biomechanics<br/>Role of muscles in accidental injury<br/>Pediatric biomechanics<br/>Best practice recommendations for protecting child occupants<br/>Pedestrian injury biomechanics and protection<br/>Design and testing of sports helmets: biomechanical practical considerations<br/>Normalization and scaling for human response corridors and development of injury risk curves<br/>Injury criteria and motor vehicle regulations<br/>Civil aviation crash injury protection<br/>Ballistic injury biomechanics.

::Summary## This book summarizes how the renin angiotensin system is implicated in the progression of atherosclerotic disease as well as of left ventricular dysfunction and reviews the action of angiotensin converting enzyme inhibitors and AT1 receptor antagonists on reducing morbidity and mortality in patients with left ventricular dysfunction or in those at high cardiovascular risk with preserved ventricular function. ACEi and ARBS in Hypertension and Heart Failure is a highly practical reference reviewing the evidence and providing a rationale for the appropriate use of RAS antagonists in cardiovascular diseases. It is written in an easy-to-follow format and with many illustrations to aid clarity and the assimilation of information. Each chapter is written by established authorities in their fields who are also experienced in explaining often complex concepts. The result is a unique book which is not only comprehensive but also clear and useful for the busy medical practitioner.<br/>::Contents##<br/>Pathogenetic mechanisms of RAS involvement in cardiovascular diseases<br/>Antiotensin converting enzyme inhibitors and at1 antagonists for treatment of hypertension.- Renin angiotensin system antagonism in heart failure<br/>Impact of co-morbidities on RAS inhibitors choice in hypertensive and heart failure patients<br/>Target organ damage and RAS blockade.

::Contents##<br/>Surgical anatomy / Norbert Peter Tesch, Axel Gänsslen, Friedrich Anderhuber, Wolfgang Grechenig, and Stephan Grechenig<br/>Biomechanics / Axel Gänsslen, Michael Nerlich, and Stephan Grechenig<br/>Radiological diagnostics / Axel Gänsslen and Stephan Grechenig<br/>Classification of acetabulum fractures / Axel Gänsslen, Stephan Grechenig, and Michael Nerlich<br/>Epidemiology / Paul Schmitz, Axel Gänsslen, and Florian Baumann<br/>Indications and planning / Michael Müller, Daniel Popp, Axel Gänsslen, and Matej Cimerman<br/>Approaches / Axel Gänsslen, Stephan Grechenig, Norbert Peter Tesch, Friedrich Anderhuber, Wolfgang Grechenig, Hans-Gunther Clement, and Jan Lindahl<br/>Posterior wall fractures / Axel Gänsslen, Arne Berner, Michael Nerlich, and Mario Staresinic<br/>Posterior column fractures / Axel Gänsslen, Stephan Grechenig, Michael Nerlich, and Bore Bakota<br/>Associated posterior column and posterior wall fractures / Veronika Matzi, Axel Gänsslen, and Michael Nerlich<br/>Anterior wall fractures / Gloria Hohenberger, Axel Gänsslen, Paul Schmitz, Daniel Popp, and Jan Lindahl<br/>Anterior column fractures / Axel Gänsslen, Paul Schmitz, and Michael Nerlich<br/>Associated anterior column plus posterior hemitransverse fractures / Michael Müller, Axel Gänsslen, and Michael Nerlich<br/>Pure transverse fractures / Axel Gänsslen, Michael Mueller, and Michael Nerlich<br/>Transverse plus posterior wall fractures / Michael Müller, Axel Gänsslen, and Michael Nerlich<br/>T-type fractures / Axel Gänsslen, Michael Müller, and Michael Nerlich<br/>Both-column fractures / Axel Gänsslen, Thomas Dienstknecht, Michael Nerlich, and Jan Lindahl<br/>Fractures in the elderly / Florian Baumann, Paul Schmitz, Michael Müller, and Axel Gänsslen<br/>Acetabular fractures in children / Axel Gänsslen and Florian Baumann<br/>Heterotopic ossifications / Axel Gänsslen, Johannes Weber, and Michael Müller<br/>Thromboembolic complications / Axel Gänsslen, Johannes Weber, and Michael Müller<br/>Special screws and views / Axel Gänsslen, Frank Hildebrand, Markus Klebingat, Michael Nerlich, and Jan Lindahl<br/>Outcome scoring / Christian G. Pfeifer, Arne Berner, Michael Müller, and Axel Gänsslen<br/>Femoral head fractures : Pipkin IV / Axel Gänsslen and Stephan Grechenig<br/>Periprosthetic acetabular fractures / Axel Gänsslen, Paul Schmitz, and Frank Hildebrand.

::Contents##<br/>Practical actions for healthcare providers / Val Moore<br/>Identifying a high quality evidence base / Paul Chrisp and Sara Twaddle<br/>Key challenges to implementation and effective interventions / Elaine Whitby and Julie Royce<br/>Using financial systems to support improved care / Jennifer Field<br/>Using measurement to support change and improvements in healthcare / Nick Baillie<br/>Conclusion and reflections / Danny Keenan and Sasha Abraham.

::Summary## "The idea of person-centred health systems is widely advocated in political and policy declarations to better address health system challenges. A person-centred approach is advocated on political, ethical and instrumental grounds and believed to benefit service users, health professionals and the health system more broadly. However, there is continuing debate about the strategies that are available and effective to promote and implement 'personcentred' approaches. This book brings together the world's leading experts in the field to present the evidence base and analyse current challenges and issues. It examines 'person-centredness' from the different roles people take in health systems, as individual service users, care managers, taxpayers or active citizens. The evidence presented will not only provide invaluable policy advice to practitioners and policymakers working on the design and implementation of person-centred health systems but will also be an excellent resource for academics and graduate students researching health systems in Europe"-- Provided by publisher.<br/>::Contents##<br/>The person at the centre of health systems : an introduction<br/>Person-centredness : exploring its evolution and meaning in the health system context<br/>Person-centred health systems : strategies, drivers and impacts<br/>Achieving person-centred health systems : levers and strategies<br/>Community participation in health systems development<br/>Patient and public involvement in research<br/>Listening to People : measuring views, experiences and perceptions<br/>Choosing providers<br/>Choosing payers : can insurance competition strengthen person-centred care?<br/>The service user as manager of care : the role of direct payments and personal budgets<br/>Choosing treatments and the role of shared decision-making<br/>The person at the centre? : the role of self-management and self-management support<br/>Patients' rights : from recognition to implementation.

::Summary## This publication offers a systemic analysis of sustainability in the food system, taking as its framework the Sustainable Development Goals of the 2030 Agenda of the United Nations. Targeted chapters from experts in the field cover main challenges in the food system and propose methods for achieving long term sustainability. Authors focus on how sustainability can be achieved along the whole food chain and in different contexts. Timely issues such as food security, climate change and migration and sustainable agriculture are discussed in depth. The volume is unique in its multidisciplinary and multi-stakeholder approach. Chapter authors come from a variety of backgrounds, and authors include academic professors, members of CSO and other international organizations, and policy makers. This plurality allows for a nuanced analysis of sustainability goals and practices from a variety of perspectives, making the book useful to a wide range of readers working in different areas related to sustainability and food production. The book is targeted towards the academic community and practitioners in the policy, international cooperation, nutrition, geography, and social sciences fields. Professors teaching in nutrition, food technology, food sociology, geography, global economics, food systems, agriculture and agronomy, and political science and international cooperation may find this to be a useful supplemental text in their courses.<br/>::Contents##<br/>Intro; Foreword; Preface; Acknowledgments; Contents; Part I: Current Issues; Understanding the Global Food System; 1 Introduction; 2 Nutrition Challenges; 2.1 Nutritional Challenges in the SDGs; 3 Food and the Environment; 3.1 Food and the Environment in the SDGs; 4 Food Loss and Waste; 4.1 Food Loss and Waste in the SDGs; 5 The Pathway Towards Sustainable and Healthy Food Systems; References; Climate Change, Sustainable Agriculture and Food Systems: The World After the Paris Agreement; 1 Introduction; 1.1 Climate Change and Agriculture 1.2 The Paris Agreement: Implications for the Agriculture Sector2 A Paradigm Shift in Agriculture: From Carbon Source to Sink; 2.1 Demand-Side Drivers of a Sustainable Food System; 2.2 Solutions and Tools; 3 Conclusions; References; Drivers of Migration in the Trans-Mediterranean Region: The Likely Role of Climate Change and Resource Security in the Geopolitical Context; 1 Introduction; 2 Climate Change Assessments: An Overview; 3 The Trans-Mediterranean Migration Routes; 4 Data and Methods; 4.1 Geographical Context; 4.2 Methods and Data for the Historical and Future Analysis; 4.2.1 Climate 2 The Roles of the Eco-Agri-Food System in Disease Incidence2.1 Hunger-Related Morbidity, Obesity, Diabetes Mellitus and Metabolic Disorders; 2.1.1 Extent; 2.1.2 Some Societal Costs; 2.1.3 The Role of Diets; 2.1.4 The Role of Food Quality; 2.1.5 The Role of the Agri-Environment; 2.2 Cardiovascular Diseases; 2.2.1 Extent; 2.2.2 Some Societal Costs; 2.2.3 The Role of Diets; 2.2.4 The Role of Food Quality; 2.2.5 The Role of the Agri-Environment; 2.3 Infectious Diseases: Food-Borne and Zoonotic Diseases; 2.3.1 Extent; 2.3.2 Societal Costs; 2.3.3 The Role of Diets; 2.3.4 The Role of Food Quality 3.1 The Mediterranean Diet for Prevention of Cardiovascular Disease, Diabetes and Cancer3.2 Characteristics of the Mediterranean Diet; 3.3 Mediterranean Diet and Chronic Degenerative Diseases: Insights on Potential Mechanisms; 3.3.1 Dietary Fat; 3.3.2 Carbohydrate Rich Foods; 3.4 Towards a Comprehensive Nutritional Approach to Prevent Chronic Non Communicable Diseases: The Role of the Traditional Mediterranean Diet; 4 Possible Role of Nutrition to Prevent Chronic Degenerative Diseases and Improve Health Span; 5 Conclusion; References; Eco-Agri-Food Ecology and Human Health; 1 Introduction 4.2.2 Water Resources4.2.3 Agriculture; 5 Results; 5.1 Climate; 5.2 Water Resources; 5.3 Agriculture; 6 Conclusions and Recommendations; References; Nutrition, Health and Dietary Trends; 1 Nutrition and Global Non-communicable Diseases; 2 Evolution of Nutrition Guidelines: A Shift from Nutrients to Dietary Patterns; 2.1 Nutrient-Disease Risk Model; 2.2 Dietary Pattern-Based Clinical Practice Guidelines; 3 The Relationship Between Dietary Patterns and Chronic Non-communicable Diseases: The Mediterranean Diet

::Contents##<br/>v. 1. Biographie<br/>v. 2. Bibliographie<br/>v. 3. Briefwechsel

::Summary## This book provides a concise yet comprehensive overview of acid-base disorders. Each chapter reviews an acid-base disorder, covering pathophysiology, evaluation, and management of the disorder. The chapters include clinical cases and a Q & A section, based on scenarios and questions that clinicians regularly encounter when treating patients with these disorders. The book concludes with two chapters on acid-based disorders in special patient populations, including critically ill patients, pregnant patients, and surgical patients. Written by an expert in the field, Acid-Base Disorders: Clinical Evaluation and Management is a state-of-the-art resource that should assist clinicians and practitioners in managing patients with acid-base disorders.<br/>::Contents##<br/>Introduction to Acid-Base<br/>Basic Acid-Base Chemistry and Physiology<br/>Methods to Assess Acid-Base Disorders<br/>Acid-Base Disorders: General Considerations and Evaluation<br/>Lactic Acidosis<br/>Ketoacidosis<br/>Toxin-Induced Acid-Base Disorders<br/>Renal Tubular Acidosis<br/>Acid-Base Disorders in Gastrointestinal Diseases<br/>Acid-Base Disorders in Kidney Disease<br/>Metabolic Alkalosis<br/>Respiratory Acidosis<br/>Respiratory Alkalosis<br/>Mixed Acid-Base Disorders<br/>Drug-Induced Acid-Base Disorders<br/>Acid-Base Disorders in Critically Ill Patients<br/>Acid-Base Disorders in Liver Disease<br/>Acid-Base Disorders in Total Parenteral Nutrition<br/>Acid-Base Disorders in Pregnancy<br/>Acid-Base Disorders in Surgical Patients.

::Summary## "The ACL-Deficient Knee: A Problem Solving Approach, focuses on problem analysis and problem solving, as well as analyzing the possibility of prevention. In each chapter, the biomechanics, anatomy, etc. that are relevant to the topic are reviewed. There are chapters where highly specialized surgical techniques are presented (v. gr. double bundle reconstruction or meniscal transplant), as well as developing areas such as ACL tears in children, where we are finding a growing number of injuries due to the increase of sports at early ages."--publisher's website<br/>::Contents##<br/>Part I: Current Status and Controversies in the ACL-Deficient Knee Problem<br/>What Have We Learned from the Kaiser Permanente Anterior Cruciate Ligament Reconstruction Registry (KP ACLRR)?<br/>The Danish Anterior Cruciate Ligament Reconstruction Registry: What We Are Doing, How We Do It, and Which Would Be the Best Way to Do It<br/>ACL Ruptures in the Female Athlete: Can We Predict Who Is at Increased Risk and Can We Reduce Noncontact Injury Rates?<br/>Anterior Cruciate Ligament Surgery: Risk Factors for Development of Osteoarthritis: What Can We Do to Prevent It?<br/>The Need for an Objective Measurement In Vivo of Rotational Stability of the ACL-Deficient Knee: How Can We Measure It?<br/>Guidelines for Operative Versus Nonoperative Management of Anterior Cruciate Ligament Injuries<br/>The Stimulation of Healing of the Anterior Cruciate Ligament: Research and Clinical Relevance<br/>ACL Primary Repair: What We Did, the Results, and How It Helps Today to Tailor Treatments to the Patient and the Pathology<br/>Graft Choice in ACL Reconstruction: Which One and Why?<br/>Graft Healing in ACL Reconstruction: Can We Enhance It in Clinical Practice?<br/>Is Double-Bundle ACL Reconstruction Necessary?<br/>ACL Injuries in Skeletally Immature Patients and Adolescents: How Can We Improve the High Rate of Poor Outcomes?<br/>Indications for Ancillary Surgery in the ACL-Deficient Knee<br/>Outpatient ACL Surgery: Is It Safe?<br/>Factors Related to Return to Sport After ACL Reconstruction: When Is It Safe?<br/>Return to Sports After ACL Reconstruction Surgery: A Risk for Further Joint Injury?<br/>Psychological Factors in the ACL Reconstruction Population: Are They Predictive of Patient Outcomes?<br/>Part II: Clinical Practice: The Problem - The Solution<br/>Acute Anterior Cruciate Ligament Tear Surgery: Repair Versus Reconstruction - When?<br/>Partial Chronic Anterior Cruciate Ligament Tears: What to Do<br/>Chronic Anterior Cruciate Ligament Tear: Single-Bundle ACL Reconstruction: Anteromedial Portal Versus Transfemoral Outside-In Versus Transtibial Drilling Technique<br/>Anterior Cruciate Ligament Tear: Rationale and Indications for Anatomic ACL Reconstruction<br/>Clinical Relevance of Meniscus in the Treatment of the ACL-Deficient Knee: The Real Value of Meniscal Transplantation<br/>Clinical Relevance of Chondral Lesions in the Treatment of the ACL-Deficient Knee: Microfracture Technique<br/>The Role of High Tibial Osteotomy in the ACL-Deficient Knee<br/>ACL Injuries Combined with Lateral and Medial Knee Injuries Acute Versus Chronic Injury: What to Do<br/>ACL Injuries in Children: Treatment and Outcomes - Personal Experience<br/>Combined Anterior Cruciate Ligament Reconstruction with Patella Tendon Lengthening Following a Complex Knee Injury<br/>Part III: Complications After ACL Reconstruction: Can We Do Better? - Prevention and Treatment<br/>Reducing the Risk of a Reinjury Following ACL Reconstruction: What Factors Should Be Used to Allow Unrestricted Return to Sports Activities?<br/>Anterior Knee Pain After ACL Reconstruction: How to Avoid It<br/>Limitation of Joint Range of Motion After Surgery of the Anterior Cruciate Ligament<br/>Septic Arthritis After Anterior Cruciate Ligament Reconstruction<br/>Deep Venous Thrombosis and Pulmonary Embolism After ACL Reconstruction: What Can We Do to Prevent It?.

::Summary## This book examines the short- and long-term impact of ACL injuries, covering training programs shown to reduce the rate of injuries in female athletes, and post-surgical rehabilitation for reducing the risk of future injury. Includes many color illustrations.

::Contents##<br/>Part I. Anatomy and Histology of the ACL<br/>Chapter 1. Functional Anatomy of the ACL Fibers on the Femoral Attachment<br/>Chapter 2. The Anatomical Features of ACL Insertion Sites and Their Implications for Multi-Bundle Reconstruction<br/>Chapter 3. Discrepancy Between Macroscopic and Histological Observations<br/>Chapter 4. Tibial Insertion of the ACL: 3D-CT Images, Macroscopic, and Microscopic Findings<br/>Chapter 5. Mechanoreceptors in the ACL<br/>Part II. Biomechanics of the ACL<br/>Chapter 6. Mechanical Properties and Biomechanical Function of the ACL<br/>Chapter 7. Biomechanics of the Knee with Isolated One Bundle Tear of the Anterior Cruciate Ligament<br/>Chapter 8. Function and Biomechanics of ACL Remnant<br/>Chapter 9. Biomechanics of Single- and Double-Bundle ACL Reconstruction<br/>Chapter 10. ACL Injury Mechanisms<br/>Part III. Diagnostics of ACL Injury<br/>Chapter 11. Physical Examinations and Device Measurements for ACL Deficiency<br/>Chapter 12. Diagnostics of ACL Injury Using Magnetic Resonance Imaging (MRI)<br/>Chapter 13. Diagnosis of Injured ACL Using Three-Dimensional Computed Tomography: Usefulness for Preoperative Decision Making<br/>Part IV. Basic Knowledge of ACL Reconstruction<br/>Chapter 14. Graft Selection<br/>Chapter 15. Portal Placement<br/>Chapter 16. Femoral Bone Tunnel Placement<br/>Chapter 17. Tibial Bone Tunnel Placement in Double-Bundle Anterior Cruciate Ligament Reconstruction Using Hamstring Tendons<br/>Chapter 18. Tensioning and Fixation of the Graft<br/>Chapter 19. Tendon Regeneration after Harvest for ACL Reconstruction<br/>Chapter 20. Second-Look Arthroscopic Evaluation after ACL Reconstruction<br/>Chapter 21. Bone Tunnel Changes After ACL Reconstruction<br/>Chapter 22. Graft I impingement<br/>Chapter 23. Fixation Procedure<br/>Part V Multiple bundle ACL Reconstruction<br/>Chapter 24. Single- vs. Double-Bundle ACL Reconstruction<br/>Chapter 25. Anatomic Double-Bundle Reconstruction Procedure<br/>Chapter 26. Triple-Bundle ACL Reconstruction with the Semitendinosus Tendon Graft<br/>Part VI. ACL Augmentation<br/>Chapter 27. History and Advantages of ACL Augmentation<br/>Chapter 28. Surgical Technique of ACL Augmentation<br/>Part VII. ACL Reconstruction Using Bone-Patella Tendon-Bone<br/>Chapter 29. An Overview<br/>Chapter 30. Anatomical Rectangular Tunnel ACL Reconstruction with a Bone-Patellar Tendon-Bone Graft<br/>Chapter 31. Rectangular vs. Round Tunnel<br/>Part VIII. Computer-Assisted Navigation in ACL Reconstruction<br/>Chapter 32. Intraoperative Biomechanical Evaluation Using a Navigation System<br/>Chapter 33. Application of Computer-Assisted Navigation<br/>Part IV. ACL Injury in Patients with Open Physes<br/>Chapter 34. ACL Reconstruction with Open Physes<br/>Chapter 35. Avulsion Fracture of the ACL<br/>Part V. Revision ACL Reconstruction<br/>Chapter 36. Double-Bundle Technique<br/>Chapter 37. Bone-Patellar Tendon-Bone Graft via Round Tunnel<br/>Chapter 38. Anatomical Revision ACL Reconstruction with Rectangular Tunnel Technique<br/>Chapter 39. One- vs. Two-Stage Revision Anterior Cruciate Ligament Reconstruction<br/>Part VI. Complications of ACL Reconstruction<br/>Chapter 40. Complications of ACL Reconstruction<br/>Part VII. Future of ACL Reconstruction<br/>Chapter 41. Future Challenges of Anterior Cruciate Ligament Reconstruction: Biological Modulation Using a Growth Factor Application for Enhancement of Graft Healing<br/>Chapter 42. Strategies to Enhance Biological Tendon-Bobe Healing in Anterior Cruciate Ligament Reconstruction<br/>Chapter 43. Tissue engineering approach for ACL healing.

::Contents##<br/>Part 1: Overview of ACLS. Introduction ; Systems of care ; Systematic approach<br/>Part 2: Preventing arrest. Recognition: signs of clinical deterioration ; Acute coronary syndromes ; Acute stroke ; Bradycardia ; Tachycardia: stable and unstable<br/>Part 3: High-performance teams. High-performance team roles and dynamics ; Respiratory arrest ; Cardiac arrest: VF/pVT ; Cardiac arrest: PEA and asystole ; Cardiac arrest: selected special situations ; Post-cardiac arrest care<br/>Appendices: Testing checklists and learning station checklists ; ACLS pharmacology summary table ; Science summary table ; Glossary.

::Summary## This book brings together world-famous acne researchers and specialists to compile a source of comprehensive, state-of-the-art information for management of acne. It examines acne as a chronic skin disease from pathogenesis to treatment. The book covers the clinical aspects of acne, topical treatments, light therapies, environmental factors and more alongside real patient photos from around the world. Treatments that chapters explore include photodynamic therapy and topical retinoids. In addition to genetic and hormonal causes of acne, chapters also include discussions on the connections between acne and diet, and acne and environmental factors. International contributors make this text unique in that it can focus solely on acne but also include international factors. Throughout the text, authors present the most up-to-date knowledge of acne pathophysiology, clinical features, differential diagnosis, treatment, and more. Pathophysiology, in particular, includes information on bacteria, immunity, endocrinologic factors, various deteriorating factors and environmental factors. As for clinical features, adult acne, differences in clinical patterns by region and race, and acne fulminans are covered. Regarding treatment, the latest knowledge on existing treatments or treatment methods, new drugs, and core outcome measures are mentioned. Acne: Current Concepts and Management is written for the dermatologist community from resident to researcher to privately practicing clinician.<br/>::Contents##<br/>Chapter 1: Update on Cutibacterium acnes<br/>Chapter 2: Updates in Isotretinoin<br/>Chapter 3: Developing a Core Outcome Set for Acne Clinical Trials: Towards Standardization and Harmonization<br/>Chapter 4: Adult Acne Vulgaris<br/>Chapter 5: Topical Retinoids and Acne.-Chapter 6: New Drug Developments in Acne<br/>Chapter 7: Scientific Connection between Acne and Diet<br/>Chapter 8: Photodynamic Therapy for Acne Vulgaris: Mechanism and Clinical Practice<br/>Chapter 9: Insulin Resistance Associated Acne<br/>Chapter 10: Acne fulminans<br/>Chapter 11: Acne and Environmental Factors<br/>Chapter 12: Acne on Pigmented Skin<br/>Chapter 13: Up-to-date Therapeutic Approaches for Acne Scars in a Korean Dermatology Clinic<br/>Chapter 14: Innate and Adaptive Immunity in Acne vulgaris<br/>Chapter 15: Clinical Features and Differential Diagnosis of Acne Vulgaris<br/>Chapter 16: Epidemiology of Acne in Latin America and Research News from Brazil<br/>Chapter 17: Androgens and Acne.

::Summary## Dermatologists commonly treat acne, which affects 40 to 50 million Americans each year and about 85 percent of all patients at some point in their lives. Dermatologists, primary care doctors, and pediatricians see these patients every day in practice. It is important to treat the skin effectively not only to reduce the risk of physical scarring, but also to address the negative psychosocial impact this disease carries. Improving the skin can improve self-confidence, interpersonal relationships, and performance in school or at work. Acneiform Eruptions in Dermatology is a practical, full-color guide to the differential diagnosis of acne vulgaris and the treatment of acne-like conditions. It is organized into sections by subtype of condition (e.g., infections, genetic syndromes, medication-caused) and includes a section of variants of acne that may be misdiagnosed. Within the sections, individual chapters discuss each variant of the condition and begin with a helpful bulleted summary of its defining clinical features. Extensive color clinical images appear throughout the book.<br/>::Contents##<br/>Section 1. Acne Vulgaris<br/>1. Acne Pathophysiology<br/>2. Clinical Presentation of Acne<br/>3. Topical Therapies for Acne<br/>4. Systemic Therapies for Acne<br/>5. Laser and Light Based Therapies for Acne<br/>Section 2. Infectious Diseases Mimicking Acne Vulgaris<br/>6. Bacterial Folliculitis<br/>7. Gram Negative Folliculitis<br/>8. Hot Tub Folliculitis<br/>9. Pityrosporum Folliculitis<br/>10. Tinea Barbae<br/>11. Flat Warts<br/>12. Molluscum Contagiosum<br/>13. Herpes Simplex Virus<br/>14. Varicella Zoster Virus<br/>Section 3. Variants of Acne Vulgaris<br/>15. Acne Conglobata<br/>16. Acne Excoriee<br/>17. Acne Fulminans<br/>18. Acne Mechanica<br/>19. Cushing Syndrome<br/>20. PAPA Syndrome<br/>21. Polycystic Ovary Syndrome<br/>22. Pomade Acne<br/>23. Post-Adolescent Female Acne<br/>24. SAPHO Syndrome<br/>Section 4. Genetic Syndromes Mimicking Acne Vulgaris<br/>25. Apert Syndrome<br/>26. Birt Hogg Dube Syndrome<br/>27. Brooke Spiegler Syndrome<br/>28. Cowden Syndrome<br/>29. Gardner Syndrome<br/>30. Gorlin Syndrome<br/>31. Muir Torre Syndrome<br/>32. Reed Syndrome<br/>33. Tuberous Sclerosis<br/>Section 5. Other Mimickers of Acne Vulgaris<br/>34. Acne Scarring<br/>35. Eosinophilic Pustular Folliculitis<br/>36. Favre Racouchot<br/>37. Hidradenitis Suppurativa<br/>38. Perioral Dermatitis<br/>39. Photocontact Dermatitis<br/>40. Postinflammatory Pigmetnation<br/>41. Pseudofolliculitis Barbae<br/>42. Pustular Psoriasis<br/>43. Rosacea<br/>44. Rosacea Fulminans<br/>45. Sarcoidosis<br/>46. Seborrheic Dermatitis<br/>47. Steatocystoma Multiplex<br/>48. Xanthomas<br/>Section 6. Pediatric Dermatoses Mimicking Acne<br/>49. Periorifical Granulomatous Dermatitis<br/>50. Keratosis Pilaris Atrophicans<br/>51. Neonatal and Infantile Acne<br/>52. Papular Granuloma Annulare<br/>53. Precocious Puberty<br/>Section 7. Drug Induced Acneiform Eruptions<br/>54. Drug Induced Acneiform Eruptions.

::Contents##<br/>Foreword<br/>Introduction<br/>Part I Diagnosis of acquired myopathies<br/>Auto-Antibodies in Neuromuscular Disorders<br/>Electromyography<br/>Imaging of the Muscle<br/>Peripheral Nerve Ultrasound<br/>Magnetic Resonance Imaging of the Peripheral Nerve<br/>Part II Clinical Entities<br/>The Spectrum of Inflammatory Myopathies: Dermatomyositis, Polymyositis, Necrotizing Myositis and Inclusion Body Myositis<br/>Necrotising Myopathy<br/>Statin Myopathy<br/>Myasthenia Gravis<br/>Acquired Autoimmune Rippling Muscles with Myasthenia Gravis<br/>Endocrinological Myopathies<br/>Vitamin D deficiency in Muscle<br/>Intensive Care Unit Acquired Weakness<br/>Part III Neurogenic disorders<br/>Idiopathic Chronic Immune-Mediated Neuropathies: Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Multifocal Motor Neuropathy<br/>GBS Immune Neuropathies<br/>Amyotrophic Lateral Sclerosis<br/>Epidemiology and Risk Factors<br/>Paraneoplastic Diseases of the Peripheral Nervous System<br/>Diabetic Neuropathy<br/>Infectious Neuropathies<br/>Toxic Neuropathies.

::Summary## This book provides a state-of-the-art overview of the pathogenesis, diagnosis, and treatment of a range of inflammatory, autoimmune, and idiopathic disorders. The opening section covers clinical tools with a particular focus on the role of electromyography and MRI imaging. The second section then presents the differential diagnosis of acquired myopathies based on clinical, electrophysiological, muscle biopsy, and serological criteria, discussing in detail relevant clinical conditions such as including myasthenia gravis, polymyositis, and statin myopathies. The third section examines acute and chronic immune-mediated neuropathies, multifocal motor neuropathies, amyotrophic lateral sclerosis, paraneoplastic diseases, and diabetic polyneuropathy, offering clear guidance on available treatments and descriptions of the latest advances in immunotheraphy, drug therapy, and physiotherapy. This clinically oriented book also includes numerous illustrative figures and contributions by international authors from leading centers.<br/>::Contents##<br/>Part I Diagnostic Tools<br/>Autoantibodies in neuromuscular Disorders<br/>Electromyography<br/>Imaging of the Muscle<br/>Peripheral of the Muscle<br/>Magnetic Resonance Imaging of the Peripheral Nerve<br/>Part II Clinical Myology Entities<br/>The Spectrum of Inflammatory Myopathies: Dermatomyositis, Polymyositis and Inclusion-Body<br/>Necrotizing Autoimmune myopathy<br/>Statin Myopathy<br/>Myasthenia Gravis<br/>Endocrinological Myopathies<br/>Vitamin D Deficiency in Muscle<br/>Intensive Care Unit-Acquired Weakness<br/>Experimental pharmacological interventions<br/>Part III Neurogenic Disorders<br/>Idiopathic Chronic Immune-Mediated Neuropathies: Chronic Inflammatory Demyelinating Polyradiculoneuropathy<br/>Immune Neuropathies<br/>Amyotrophic Lateral Sclerosis: Epidemiology and Risk<br/>Paraneoplastic Diseases of the Peripheral Nervous System<br/>Diabetic Neuropathy<br/>Infectious Neuropathies<br/>Toxic neuropathies.

::Summary## Acquisition of Complex Arithmetic Skills and Higher-Order Mathematics Concepts focuses on typical and atypical learning of complex arithmetic skills and higher-order math concepts. As part of the series Mathematical Cognition and Learning, this volume covers recent advances in the understanding of children's developing competencies with whole-number arithmetic, fractions, and rational numbers. Each chapter covers these topics from multiple perspectives, including genetic disorders, cognition, instruction, and neural networks. Covers innovative measures and recent methodological advances in mathematical thinking and learning Contains contributions that improve instruction and education in these domains Informs policy aimed at increasing the level of mathematical proficiency in the general public.

::Contents##<br/>1. History of Acrodermatitis Enteropathica<br/>2. Epidemiology and Etiology<br/>2.1. Epidemiology<br/>2.2. Etiology<br/>2.2.1. Molecular Etiology of AE<br/>2.2.2. Hypothetical Etiology 1: the Alteration of Zinc Bioavailability<br/>2.2.3. Hypothetical Etiology 2: a Defective Zinc Transporter<br/>2.2.4. Alternative Forms of AE-like Zinc Deficiencies<br/>3. Analysis of Disorder<br/>3.1. Clinical Forms of AE<br/>3.2. Nomenclature of Zinc Deficiencies<br/>3.3. Acquired Non-hereditary Zinc Deficiency<br/>3.3.1. Zinc Deficient Maternal Breast Milk<br/>3.3.2. Zinc Deficient Caused by Metabolism Disorders<br/>4. Clinical Symptoms<br/>5. Diagnosis<br/>5.1. Laboratory Diagnosis of Zinc Deficiency<br/>5.2. Histopathology<br/>5.3. Biological Diagnosis of AE<br/>5.4. Clinical Diagnosis<br/>5.5. Molecular Diagnosis<br/>5.6. Differential Diagnosis<br/>6. Disease Course and Treatment<br/>6.1. Treatment<br/>7. The Role of Zinc in Different Body Systems<br/>7.1. Biochemistry of Zinc Metabolism<br/>7.2. Skin and Hair Physiology<br/>7.3. Gastrointestinal System and Other Organs<br/>7.4. Neurological Development, Growth, and Mental Status<br/>7.5. Enzymes<br/>7.6. Endocrine System<br/>7.7. Metabolism of Nucleic Acids<br/>7.8. Mitosis and Meiosis Cycles<br/>7.9. Cell Membranes<br/>7.10. Synthesis of Proteins and Collagen<br/>7.11. Immune System<br/>8. History of AE in Adults<br/>9. Iranian Hospital Cases in Literature<br/>9.1. Patient One<br/>9.2. Patient Two<br/>9.3. Patient Three<br/>9.4. Patient Four<br/>9.5. Zinc Deficiency Similarities to AE in Infants (Fifth Patient)<br/>10. Clinical Research<br/>10.1. Abstract<br/>10.2. Synopsis of Study<br/>10.3. Purpose of Study<br/>10.4. The Considered Hypotheses<br/>10.5. Introduction<br/>10.5. Methods<br/>10.6. Ethical Considerations<br/>10.7. Results<br/>10.8. Discussion<br/>11. Evaluation of Symptoms in Razi Dermatology Hospital<br/>12. Case Photos.

::Contents##<br/>Intro; Preface; Contents; About the Editor; Abbreviations;<br/> 1: Actin Polymerization: A Cellular Perspective for Motility; 1.1 Introduction; 1.1.1 Cancer and Polycystic Ovarian Syndrome (PCOS); 1.1.2 Age-Related Neurodegenerative Disorders; 1.2 Actin: A Vital Player in Cell Motility; 1.2.1 Swimming: A Cellular Motility Phenomenon; 1.2.2 Actin-Driven Cellular Motility; 1.2.2.1 Directional Motility; 1.2.2.2 Cytokinesis; 1.2.2.3 Organelle Transport and Protein Trafficking; 1.3 Gliding Motility; 1.3.1 Gliding Motility in Apicomplexan; Bibliography<br/> 2: Actin: The Central Ubiquitous Player in the Phenomenon2.1 Introduction; 2.2 Sequence Analysis of the G-Actin; 2.3 Structure of G-Actin; 2.3.1 3D Structure of G-Actin; 2.3.1.1 Architecture of G-Actin; 2.3.1.2 Loops; 2.3.1.2.1 S-Loop (Residues 11-16) and G-Loop (Residues 154-161); 2.3.1.2.2 H-Loop (Residues70-78); 2.3.1.3 Dnase-Binding Loop (D-Loop, Residues 38-52); 2.3.1.4 Loop 60-69; 2.3.1.5 W-Loop (Residues 165-172); 2.3.1.6 Hydrophobic Plug (H-Plug) (Residues 264-273); 2.3.1.7 C-Terminal (Residues 349-375) and N-Terminal (Residues 1-10) Loops; 2.4 Role of Metal Ions 2.5 Conformational States of Actin2.6 Upsi-Phosphate Sensing; 2.7 Filamentous Actin (F-Actin); 2.7.1 Actin Polymerization; 2.8 Mechanism of Actin Polymerization; 2.9 Kinetics of Actin Polymerization; 2.10 Thermodynamics of Actin Polymerization; 2.11 Stability of Actin Filament; 2.12 Drugs Binding to Actin; Bibliography;<br/> 3: Formin: The Multidomain Elongator of Actin Polymer; 3.1 Introduction; 3.2 Localization; 3.3 Function; 3.4 Domain Organization; 3.4.1 Formin Homology-1 (FH1) Domain; 3.4.2 Formin Homology-2 (FH2) Domain; 3.4.3 Diaphanous Autoregulatory Domain (DAD) 3.4.4 Other Accessory Domains3.4.5 Domain-Isotype Relationship; Bibliography;<br/> 4: Profilin: The Associates of Formin; 4.1 Introduction; 4.2 Functions; 4.3 Structure; 4.4 Binding Partners of Profilin; 4.5 Poly-Proline-Binding Site; 4.6 Actin-Binding Sites; 4.7 Affinity of Profilin for Actin; 4.8 Hydrophobic Core; 4.9 Regulators of Profilin; Bibliography;<br/> 5: ADF (Actin Depolymerizing Factor): The Breaker of the Polymer in Homeostasis; 5.1 Introduction; 5.2 Isoforms of ADF; 5.3 Functions; 5.4 Structure; 5.5 Stability of ADF; 5.6 Regulators of ADF; 5.6.1 PIP2; 5.6.2 Phosphorylation; 5.6.3 pH

::Contents##<br/>Epidemiology of actinic keratosis / Green, A.C<br/>Patients' perspectives on actinic keratosis / Esmann, S.<br/>Photodamage : all signs lead to actinic keratosis and early squamous cell cancer / Wei, J.; Kok, L.F.; Byrne, S.N.; Halliday, G.M.<br/>Dysregulation of epidermal growth factor receptor in actinic keratosis and squamous cell carcinoma / Joseph, S.R.; Munoz, L.; Gaffney, D.C.; Saunders, N.A.; Simpson, F.<br/>The actinic keratosis virome : can we prevent squamous cell carcinoma with a vaccine? / Frazer, I.H.<br/>Do actinic keratoses and superficial squamous cell carcinomas have a specific immunoprofile? / Wells, J.W.<br/>Mouse models for actinic keratosis and squamous cell carcinoma / Handoko, H.Y.; Ferguson, B.; Walker, G.J.<br/>Keratinocyte cancer and its precursors in organ transplant patients / Jenni, D.; Hofbauer, G.F.L.<br/>Clinical features of actinic keratoses and early squamous cell carcinoma / Wheller, L.; Soyer, P.<br/>The many clinico-pathologic faces of actinic keratosis : an atlas / Massone, C.; Cerroni, L.<br/>Dermoscopy of actinic keratosis, intraepidermal carcinoma and squamous cell carcinoma / Zalaudek, I.; Argenziano, G.<br/>The future of keratinocyte skin cancer surveillance : automated image analysis to identify and monitor keratinocyte dysplasia / Hames, S.C.; Prow, T.W.<br/>Reflectance confocal microscopy : hallmarks of keratinocyte cancer and its precursors / Prow, T.W.; Tan, J.-M.; Pellacani, G.<br/>Optical coherence tomography and its role for delineating the thickness of keratinocyte dysplasia and neoplasia / Themstrup, L.; Jemec, G.B.E.<br/>Teledermatology : its use in the detection and management of actinic keratosis / Janda, M.<br/>Conventional treatment of actinic keratosis : an overview / Peris, K.; Fargnoli, M.C.<br/>Field cancerization : from molecular basis to selective field-directed management of actinic keratosis / Philipp-Dormston, W.G.<br/>Update on photodynamic treatment for actinic keratosis / Wiegell, S.R.<br/>Laser treatment and its implications for photodamaged skin and actinic keratosis / de Vries, K.; Prens, E.P.<br/>Ingenol mebutate : from common weed to cancer cure / Zarchi, K.; Jemec, G.B.E.<br/>Oral nicotinamide and actinic keratosis : a supplement success story / Kim, B.; Halliday, G.M.; Damian, D.L.

::Summary## This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy. This book will engage scholars in virology and medical microbiology as well as researchers with an interest in enzymology and protein structure and function relationship.<br/>::Contents##<br/>Intro; Preface; Contents; Part I: Viral Proteins Activated By Host Proteases; 1: Activation of the Hemagglutinin of Influenza Viruses; 1.1 Structural Basis for Activation of HA Fusion Potential; 1.2 Structure of HA0 Cleavage Sites; 1.3 Activating Proteases; References; 2: Proteolytic Activation of Paramyxoviruses and Pneumoviruses; 2.1 Paramyxoviruses and Pneumoviruses; 2.2 The Role of Protease Cleavage in Fusion Protein Activation; 2.3 Proteases Involved in Paramyxovirus F Protein Proteolytic Cleavage; 2.3.1 Furin and Its Role in F Protein Cleavage. 2.3.2 Extracellular Cleavage of Paramyxovirus F Proteins with Monobasic Cleavage Sites2.3.3 The Henipavirus F proteins: Intracellular Cleavage by Endosomal Proteases; 2.4 Proteases Involved in Pneumovirus F Protein Proteolytic Cleavage; 2.4.1 Respiratory Syncytial Virus F Proteins: A Novel Case of Two Proteolytic Processing Events; 2.4.2 Extracellular Cleavage of F Proteins from the Metapneumoviruses; 2.5 F protein Proteolytic Processing, Pathogenesis, and Antiviral Approaches; 2.6 Proteolytic Activation of the Hemagglutinin-Neuraminidase Glycoprotein; References. 3.7.2 Peptide-Based Compounds and Small Molecules3.7.3 A Novel Cell-Based Sensor for SKI-1/S1P as a Platform for High-Throughput Drug Screening; 3.7.4 Use of the SKI-1/S1P Sensor to Predict Protease Use of Newly Emerging Arenaviruses; References; 4: Priming Time: How Cellular Proteases Arm Coronavirus Spike Proteins; 4.1 Introduction; 4.2 The Coronavirus Spike Protein: Viral Key for Entry into the Target Cell; 4.3 Proteolytic Priming of Coronavirus Spike Proteins: Basic Concepts; 4.4 Proteolytic Activation of the Spike Proteins of SARS-CoV and MERS-Co<br/>V. 3: Cleavage of the Glycoprotein of Arenaviruses3.1 Arenavirus Structure, Genome Organization, and Basic Virology; 3.2 Arenavirus GP Structure and Function; 3.3 The Proprotein Convertase SKI-1/S1P Cleaves Arenavirus GPC; 3.4 The Mechanism of SKI-1/S1P Processing of Arenavirus GPC Differs from Cellular Substrates; 3.5 Optimized Recognition of Arenavirus GPC by SKI-1/S1P: Viral Advantage and Achilles' Heel; 3.6 The Processing of Reptarenavirus GPC Is Largely Unknown; 3.7 Targeting SKI-1/S1P-Mediated GPC Processing as an Anti-arenaviral Strategy; 3.7.1 Protein-Based Strategies. 4.4.1 Cathepsin L: Endosomal Activator of the Spike Protein4.4.2 Activation of the Spike Protein by Type II Transmembrane Serine Proteases at the Cell Surface; 4.4.3 Furin Can Activate Coronavirus Spike Proteins in the Constitutive Secretory Pathway of Infected Cells and During Viral Entry into Target Cells; References; 5: Proteolytic Processing of Filovirus Glycoproteins; 5.1 Introduction; 5.2 Biosynthesis and Maturation of Filovirus Glycoproteins; 5.3 The Role of GP in Host Cell Entry; 5.4 Proteases Responsible for GP Processing; References.

::Summary## The purpose of the The Active Female: Health Issues Throughout the Lifespan, 2nd Edition is twofold: (1) to increase the awareness of wellness and fitness issues for active females and their family members; and (2) to provide an avenue for medical practitioners, allied health professionals, health educators, and certified individuals in sports medicine to gain critical, updated knowledge of a field specific to active females. Part I of the book offers a foundation to help the reader understand the interrelationship among body image concerns, the female reproductive cycle, and musculoskeletal anatomy/physiology of females that makes their health risks and concerns unique. Reproductive health is discussed by a prominent researcher in reproduction/endocrinology. An overview of the Female Athlete Triad which is a syndrome of three interrelated conditions (isordered eating, menstrual disturbances and bone loss) is presented in Part II. Physicians and certified professionals in sports medicine discuss the individual components of the triad, relating not only to the athletic female but also to the recreationally active woman throughout the lifespan. In Part III, Prevention and management of common musculoskeletal injuries is addressed by a female orthopedic surgeon who sub-specializes in treating female athletes. Finally, appropriate exercise and nutritional guidelines for active females are discussed in Parts IV-V of the book by certified professionals and licensed physicians in sports medicine. An invaluable addition to the literature, The Active Female: Health Issues Throughout the Lifespan, 2nd Edition will be of great interest to physicians, allied health care practitioners, medical/other wellness educators, and students who are interested in advancing women's health issues. Sports medicine specialists, family practitioners, gynecologists, team physicians, residents in sports medicine, athletic trainers, health educators, nurses, physicians assistants, physical therapists, sport psychologists, counselors, athletic trainers, and other members of the sports medicine team should also find this title of significant interest.<br/>::Contents##<br/>Pt. I. Focusing on active female's health issues: unique gender related psychological and physiological characteristics of females<br/>Pt. II. Disordered eating issues in the active female<br/>Pt. III. Prevention and management of common musculoskeletal injuries in active females<br/>Pt. IV. Exercise guidelines and precautions for active females<br/>Pt. V. Nutrition, energy balance, and weight control.

::Summary## "This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions."--Publisher's description.<br/>::Contents##<br/>Activity-based protein profiling- enabling multimodal functional studies of microbial communities<br/>Activity-based protein profiling methods to study bacteria: the power of small-molecule electrophiles<br/>Opportunities and challenges in activity-based protein profiling of mycobacteria<br/>Activity-based protein profiling at the host-pathogen interface<br/>Chemical proteomic profiling of protein fatty-acylation in microbial pathogens<br/>How to target viral and bacterial effector proteins interfering with ubiquitin signaling<br/>ABPP and host-virus interactions<br/>Activity-based protein profiling for the study of parasite biology<br/>Deciphering T cell immunometabolism with activity-based protein profiling<br/>Small-molecular inhibitors of PARPs: from tools for investigating ADP-ribosylation to therapeutics<br/>Development of activity-based proteomic probes for protein citrullination<br/>Recent advances in activity-based protein profiling of proteases<br/>Opportunities for lipid-based probes in the field of immunology<br/>Activity-based protein profiling of non-ribosomal peptide synthetases<br/>Target identification of bioactive covalently acting natural products<br/>Applications of reactive cysteine profiling.

::Contents##<br/>I. L'énergie (points, méridiens, circulation)<br/>II. Le maniement de l'énergie.

::Summary## This book systematically introduces the Brain in Traditional Chinese Medicine (TCM) and its acupuncture treatments. It discusses the origin and development of the TCM Brain theory, and presents current research on brain and acupuncture, the unique brain related techniques such as scalp acupuncture and Dao-qi technique, the new developing acupuncture treatment methods for brain-related conditions, such as stroke, Parkinson's, dementia, Alzheimer's disease, multiple sclerosis, traumatic brain injury, autism, cerebral palsy and depression, anxiety, bipolar disorder among others. This book is of interest to TCM and acupuncture practitioners in the West, as well as acupuncture researchers and lecturers. It gives a new understanding of the brain and treatments for brain-related conditions from a complementary medicine point of view.<br/>::Contents##<br/>Part One. Acupuncture for Brain, Introduction and Theory<br/>1. Brain in original Traditional Chinese Medicine<br/>2. Acupuncture and The Brain Current Understanding<br/>3. Acupuncture Research and the Brain<br/>4. Acupuncture Brain. physiology and Pathology<br/>5. Scalp acupuncture<br/>6. Dao qi acupuncture technique<br/>7. Abdominal acupuncture<br/>8. Other Commonly used acupuncture techniques for Brain conditions<br/>9. Commonly used Herb formulas for Brain Conditions<br/>10. The Chinese View--Preserving a Healthy Functioning Brain<br/>11. Stroke<br/>12. Parkinson's disease<br/>13. Dementia and Alzheimer's disease<br/>14. Multiple Sclerosis<br/>15. Brain Injuries<br/>16. Cerebral palsy and Brain retardation.<br/>17. Other neurological conditions<br/>18. Depression<br/>19. Anxiety<br/>20. Bipolar Disease<br/>21. Autism<br/>22. Other psychological conditions<br/>23. Other brain related conditions<br/>Conclusion<br/>Appendix<br/>Index.

::Summary## Acupuncture for Pain Management is intended as the premier resource for learning the fundamentals of the art of medical acupuncture. Edited by top pain medicine specialists at Harvard and UCLA, and based on their popular annual workshop at the American Society for Anesthesiologists, the book is the perfect synthesis of Western and Chinese medicine. Anesthesiologists, pain medicine specialists, primary care physicians, osteopaths, neurologists, psychiatrists, physical medicine and rehabilitation specialists, and other health professionals looking to add acupuncture to their repertoire will benefit from the concise and practical approach of the book. Features: Each individual meridian discussed in detail acupuncture for 25 clinical conditions, including headache, menstrual pain, low back pain, insomnia, and more. Aimed at acupuncturists as well as practitioners who want to add acupuncture to their clinical armamentarium.<br/>::Contents##<br/>Part I: General Consideration<br/>1. History of Acupuncture<br/>2. Basic Theories of Traditional Chinese Medicine<br/>3. Pattern Discrimination in Traditional Chinese Medicine (TCM)<br/>4. Mechanisms of Acupuncture Analgesia<br/>5. Common Acupuncture Practices<br/>6. Peri-Operative Acupuncture<br/>7. Acupuncture Pain Research: Quantitative and Qualitative<br/>8. Auricular Acupuncture<br/>Part II: Acupuncture Channels<br/>9. Acupuncture Qi Flow and Points Measurement<br/>10. Hand Tai Yin Lung Meridian<br/>11. Hand Yang Ming Large Intestine Meridian<br/>12. Foot Yang Ming Stomach Meridian<br/>13. Foot Tai Yin Spleen Meridian<br/>14. The Hand Sho Yin Heart Meridian<br/>15. The Hand Tai Yang Small Intestine Meridian<br/>16. Foot Tai Yang Bladder Meridian<br/>17. Foot Shao Yin Kidney Meridian<br/>18. The Hand Jue Yin Pericardium Meridian<br/>19. The Hand Sho Yang Triple Energizer Meridian<br/>20. The Foot Shao Yang Gall Bladder Meridian<br/>21. The Foot Jun Yin Liver Meridian<br/>22. Conception Vessel<br/>23. Governor Vessel<br/>24. The Extra Acupuncture Points<br/>Part III: Clinical Conditions<br/>25. Headache<br/>26. Facial nerve palsy<br/>27. Vertigo<br/>28. Toothache<br/>29. Neck Pain<br/>30. Chest Pain<br/>31. Epigastic Pain<br/>32. Abdominal Pain<br/>33. Dysmenorrhea<br/>34. Upper Back Pain<br/>35. Frozen Shoulder<br/>36. Low Back Pain<br/>37. Arthritis, Joint Pain<br/>38. Coccygeal Pain<br/>39. Elbow Pain<br/>40. Wrist Pain<br/>41. Ankle Pain<br/>42. Heel Pain<br/>43. Insomnia<br/>44. Nausea and Vomiting<br/>45. Sedation<br/>46. Dizziness.

::Contents##<br/>Section I: Foundations. Principles for practice development to facilitate outcomes and productivity<br/>Billing, reimbursement, and setting up a clinic<br/>Anatomy and physiology of skin and soft tissue<br/>Wound-healing physiology and factors that affect the repair process<br/>Types of skin damage and differential diagnosis<br/>Skin and wound inspection and assessment<br/>Section II: Pressure ulcers. Pressure ulcers: impact, etiology, and classification<br/>Developing and maintaining a pressure ulcer prevention program<br/>Support surfaces<br/>Section III: Lower extremity wounds. Lower extremity assessment<br/>Arterial ulcers<br/>Venous ulcers<br/>Lymphedema<br/>Neuropathic wounds: the diabetic wound<br/>Foot and nail care<br/>Section IV: Wound bed preparation. Wound infection: diagnosis and management<br/>Wound debridement<br/>Principles of wound healing and topical management<br/>Section V: Biophysical and biologic agents. Cellular- and/or tissue-based products for wounds<br/>Molecular and cellular regulators<br/>Negative pressure wound therapy<br/>Hyperbaric oxygenation<br/>Electrical stimulation<br/>Ultraviolet light and ultrasound<br/>Section VI: Critical cofactors. Wound pain: impact and assessment<br/>Managing wound pain<br/>Nutritional assessment and support<br/>Perfusion and oxygenation<br/>Eliminating noncompliance<br/>Section VII: Acute and traumatic wounds. Uncommon wounds and manifestations of intrinsic disease<br/>Traumatic wounds: bullets, blasts, and vehicle crashes<br/>Burns<br/>Reconstructive surgery<br/>Surgical wounds and incision care<br/>Section VIII: Special patient populations. Skin care needs of the obese patient<br/>Skin care needs of the neonatal and pediatric patient<br/>Managing wounds in palliative care<br/>Management of draining wounds and fistulas<br/>Percutaneous tube management<br/>Appendix A: Tool examples to support skin and wound care<br/>Appendix B: Self-assessment exercises.

::Contents##<br/>Part I. Surgery<br/>1. Acute Appendicitis<br/>2. Acute Biliary Tract Diseases<br/>3. Acute Pancreatitis<br/>4. Nontraumatic Gastroduodenal Perforations<br/>5. Symptomatic Abdominal Wall Hernias<br/>6. Symptomatic Diaphragmatic Hernia<br/>7. Intestinal Obstruction<br/>8. Acute Inflammatory Bowel Disease<br/>9. Spleen<br/>10. Abdominal Trauma<br/>11. Miscellaneous Conditions<br/>Part II. Gynecology<br/>12. Adnexal Torsion<br/>13. (Isolated) Torsion of the Fallopian Tube<br/>14. Ruptured/Bleeding Ovarian Cysts/Tumors<br/>15. Ruptured Ectopic Pregnancy<br/>16. Spontaneous Uterine Rupture<br/>17. Torsion of the Gravid Uterus<br/>18. Degenerating Uterine Myomas<br/>19. Pelvic Inflammatory Disease and Tubo-ovarian Abscess.

::Summary## This book will help readers recognize, diagnose and efficiently treat acute abdominal disorders encountered in the pregnant patient, whether associated with or incidental to the pregnancy. Includes more than 200 figures relevant to diagnosis and treatment.

::Summary## Neglected finger injuries may lead to chronic lesions that often have detrimental consequences for the practice of a ball sport, whether at a recreational level or at the top athlete level. The initial injury management is crucial. Depending on the type and the severity of the lesions, different people may get involved: the players themselves or their entourage, physiotherapists, club doctors, emergency physicians, family doctors, sports doctors or hand surgeons. Treatment is usually conservative: the long fingers require rapid mobilization to prevent stiffness and contrary to that, the thumb requires stability. Surgery may be necessary to reach these goals especially for athletes, because of the demands of their sport. Chronic lesions are also in part related to repeated trauma, requiring specialized long-term multidisciplinary treatment. They can often lead to the end of a sporting career, but also may limit the functionality of the fingers at the time of conversion.<br/>::Contents##<br/>Ball sports<br/>Functional anatomy<br/>Hand functional anatomy<br/>Examination of the injured hand<br/>Radiological investigations<br/>Severe Hand Injuries<br/>Management of hand and finger injuries<br/>Acute finger injuries<br/>Chronic finger injuries<br/>Small joints arthroscopy<br/>Complications associated with hand surgery<br/>Rehabilitation<br/>The disabled athlete in ball sports<br/>Opinions.

::Summary## This is a comprehensive practical guide to the practice of the new subspecialty of critical care echocardiography. The text covers all aspects of clinical practice and describes how to use transthoracic echocardiography to approach and manage common clinical questions. Specific emphasis is placed on the appropriate use of clinical echocardiographic data in the context of the patient's critical illness; this is illustrated by the frequent use of case studies including both still and moving echocardiographic images. The text covers assessment of, and disorders affecting, the left and right heart, including shock and sepsis. It also looks at how to interpret diastolic information during critical illness and the effect of that illness on valve disease and function. The important subject of fluid responsiveness is explored in detail, as is the influence of organ support and illness on the diagnosis of cardiac tamponade. The information given in the text is summarized using algorithms in a field guide for the critical care echocardiographer, which also provides a rapid guide to assessing time-critical patient presentations.

::Summary## This pocket guide is a single-volume source of the most common and important formulas and laboratory values used in the daily practice of acute care and critical care medicine. Information is presented in outline format and as tables, graphics, and algorithms to facilitate quick look up. Acute and Critical Care Formulas and Laboratory Values is designed to help clinicians interpret clinical data, apply formulas, understand laboratory values, and integrate this information with their knowledge of pathophysiology to promote the delivery of evidence-based care. Essential formulas and laboratory values. Multiple ways to derive a value, where appropriate. Non-clinical formulas useful for understanding physiologic concepts or that underlie diagnostic tests or clinical measurement.<br/>::Contents##<br/>Cardiovascular Formulas and Facts<br/>Endocrinology and Metabolism Formulas<br/>Environmental Facts and Formulas<br/> Gastrointestinal Facts and Formulas<br/>Hematological Facts and Formulas<br/>Infectious Diseases Formulas and Facts<br/> Neurological Formulas and Facts<br/>Nutrition Formulas and Facts<br/>Obstetrics & Gynecology Formulas and Facts<br/>Oncology Formulas<br/>Pediatric Formulas and Laboratory Values<br/>Pulmonary Formulas and Facts<br/>Renal, Fluid & Electrolyte Formulas and Facts<br/>Statistics and Epidemiology<br/>Toxicology Formulas and Facts<br/>Trauma Facts and Formulas<br/>Common Laboratory Values.

::Contents##<br/>1. An Introduction to the Acute Care for Elders / Michael L. Malone, Ji Won Yoo, and James S. Goodwin<br/>2. The Team Approach to Interdisciplinary Care / Maryjo Cleveland, Carolyn Holder, Ariba Khan, and Aileen Jencius<br/>3. Patient and Hospital Factors That Lead to Adverse Outcomes in Hospitalized Elders / Edgar Pierluissi, Deborah C. Francis, and Kenneth E. Covinsky<br/>4. An Overview of Hospital-Based Models of Care / Elizabeth A. Capezuti and Marie Boltz<br/>5. The Acute Care for Elders Unit / Robert M. Palmer and Denise M. Kresevic<br/>6. How to Develop, Start, and Sustain an Acute Care for Elders Unit / Ellen S. Danto-Nocton, Carolyn Holder, Rebecca Ramsden, Jonny Macias Tejada, Anita Steliga, and Karen Padua<br/>7. How to Disseminate the ACE Model of Care Beyond One Unit / Roger Y. Wong, Marsha Vollbrecht, and Patti Pagel<br/>8. How to Use the ACE Unit to Improve Hospital Safety and Quality for Older Patients: From ACE Units to Elder-Friendly Hospitals / Samir K. Sinha, Sandra Liliana Oakes, Selma Chaudhry, and Theodore T. Suh<br/>9. ACE Unit Business Model / Kyle Allen, Peter DeGolia, Susan Hazelett, and Diane Powell<br/>10. Models of Care to Transition from Hospital to Home / Ella Harvey Bowman, Kellie L. Flood, and Alicia I. Arbaje<br/>11. What Is the Role of Hospitalists in the Acute Care for Elders? / Heidi L. Wald and Melissa L. P. Mattison<br/>12. How to Improve Care for Seniors in the Emergency Department / Soryal Soryal, Marie Boltz, Scott Wilber, and Michael L. Malone<br/>13. How to Improve Care for Older Patients in the Intensive Care Unit / Leanne Boehm, E. Wesley Ely, and Lorraine Mion<br/>14. The Future of Acute Care for Elders / Kanwardeep Singh and Michael L. Malone.

::Summary## Acute Care General Surgery provides a succinct focused overview of a myriad of general surgical emergencies. Each chapter has a concise, practical framework on the workup and management of a specific topic. The book covers a wide array of pathology from the more common appendicitis, diverticulitis and cholecystitis to those less frequently encountered such as toxic megacolon, Fournier's gangrene and volvulus. Learning objectives for each chapter are clearly defined. In addition to differential diagnosis, the work up and management is comprehensively discussed. In addition, a pithy clinical pearl is included to serve as a memory aid for each diagnosis. Upon reviewing this volume, clinicians who encounter the acute care surgical patient in their practices will be better equipped to rapidly assess, evaluate, diagnose and managing their complex and often challenging problems.<br/>::Contents##<br/>Appendiceal Mucocele<br/>Aute Appendicitis<br/>Colonic Volvulus<br/>Acute Cholecystitis/Biliary Disease<br/>Diverticulitis of the Colon<br/>Enterocutaneous Fistula<br/>Fournier's Gangrene<br/>Upper Gastrointestinal Bleeding<br/>Lower Gastrointestinal Bleeding<br/>Acute Anorectal Emergencies<br/>Incarcerated Groin Hernias<br/>Intussusception<br/>Meckel's Diverticulitis<br/>Necrotizing Soft Tissue Infections<br/>Pancreatic Pseudocysts<br/>Paraesophageal Hernia<br/>Pneumobilia<br/>Pneumoperitoneum<br/>Portal Venous Gas<br/>Small Bowel Diverticulitis<br/>Small Bowel Obstruction<br/>Small Bowel Perforation<br/>Toxic Megacolon<br/>Acute Pancreatitis<br/>Peptic Ulcer Disease.

::Contents##<br/>Part 1. Introduction<br/>1. Acute Care Setting<br/>2. The Medical Record<br/>Part 2. Body Systems<br/>3. Cardiac System --4. Pulmonary System<br/>5. Musculoskeletal System<br/>6. Nervous System<br/>7. Vascular System and Hematology<br/>8. Gastrointestinal System<br/>9. Genitourinary System<br/>10. Endocrine System<br/>Part 3. Diagnoses<br/>11. Oncology<br/>12. Burns and Wounds<br/>13. Infectious Diseases<br/>14. Organ Transplantation<br/>15. Fluid and Electrolyte Imbalances<br/>16. Amputation<br/>17. Physical Therapy Considerations for Patients Who Complain of Chest Pain<br/>Part 4. Interventions<br/>18. Medical-Surgical Equipment in the Acute Care Setting<br/>19. Pharmacologic Agents<br/>20. Anesthesia: Perioperative Considerations for the Physical Therapist<br/>21. Acute Pain Management<br/>22. Postural Drainage<br/>23. Functional Tests<br/>Appendix A. Preferred Practice Patterns.

::Summary## This book reviews the common clinical scenarios that might trigger emergent consultation for neurosurgical intervention, with attention to key components of the clinical interview and exam, optimal diagnostic evaluation, indications for and the goals of operative intervention, perioperative considerations, and strategies for complication mitigation. This is not a surgical atlas, but rather, a road map for the journey to the operating room door. The intent is to establish a systematic, evidence-based action plan for the patient presenting in neurologic crisis. Each chapter opens with a relevant case vignette and then unfolds through uniform sections to tell the story of how one might approach the disease entity in question, from initial request for consultation to definitive management, highlighting steps of the decision-making process. Each chapter is punctuated by 3-5 teaching pearls, summarizing these key elements. The overall goal is to create a framework for assessment that might be applied in the emergency department, the trauma bay, or the ICU when a neurologic emergency arises. The scope encompasses not only cranial and spinal trauma, but also entities such as shunt failure, stroke, aneurysmal subarachnoid hemorrhage, pituitary apoplexy, cauda equina syndrome, and central nervous system infection that might require time-sensitive intervention. An additional section addresses issues requiring emergent neurosurgical response in the ICU setting, including sudden neurologic worsening, status epilepticus, and abnormal clotting/ coagulopathy. .

::Summary## "Substantially updated with more illustrations and brand-new chapters that reflect the growth and advances in the field, this latest edition of Acute Care Surgery features an editorial board drawn from the ranks of trauma surgery, emergency surgery, and critical care surgery. A comprehensive, updated, and timely overview of this fledgling specialty!"--Provided by publisher.

::Contents##<br/>Section I. Radiology basics<br/>Section II. Abdomen<br/>Section III. Chest<br/>Section IV. Soft tissue<br/>Section V. Trauma.

::Summary## This pocket manual is a practically oriented, wide-ranging guide to acute care surgery general aspects and℗ℓto non-gastrointestinal emergencies. It covers the most common problems in thoracic, obstetric, gynecologic, anorectal, vascular and skin surgery and also includes chapters on postoperative complications in bariatric surgery, antibiotic management, nutrition and interventional radiology in acute care surgery. This guide stems from collaboration with the World Society of Emergency Surgery (WSES) and aims to provide general surgeons, ℗ℓresidents and trainees with a comprehensive and up-to-date overview℗ℓof the℗ℓmost relevant operative techniques and with useful℗ℓ "tips and tricks" applicable in daily clinical practice. A second volume on gastrointestinal and abdominal surgical emergencies is also available.<br/>::Contents##<br/>1. Acute care surgery around the world: future perspectives<br/>2. A history of acute care suregry<br/>3. Scientific Research in emergency surgery setting<br/>4. Organization of an acute care surgery service and patient safety management<br/>5. Safety and the use of checklists in acute care surgery<br/>6. Emergencies in otolaryngology<br/>Head & Neck Surgery<br/>7. Hemothorax, pneumothorax and chest empyema<br/>8. Anorectal emergencies<br/>9. Skin and Soft Tissue Infections<br/>10. Surgical Site Infections and their Management<br/>11. Non-Traumatic Peripheral Vascular Emergencies<br/>12. Ruptured abdominal aortic aneurysms and major vascular injuries<br/>13. Obstetrics-Gynecology Emergencies<br/>14. Genito Urinary Emergencies<br/>15. Critical Care in Acute Care Surgery<br/>16. Septic Shock and Resuscitation Strategies<br/>17. Antibiotic management in acute care surgery<br/>18. Nutrition in sepsis and acute surgical patients<br/>19. Point-of-Care Ultrasound in Critically-Ill Patients<br/>20. Interventional Radiology for non-traumatic acute thoraco-abdominal bleeding<br/>21. Percutaneous Techniques for Management of Intra-Abdominal Abscesses<br/>22. Damage Control Surgery for Emergency General Surgery<br/>23. The Abdominal Compartment Syndrome<br/>24. Common Pediatric Surgical Emergencies<br/>25. Common Surgical Emergencies in Transplanted Patients<br/>26. Emergency management of caustic injuries<br/>27. Surgical emergencies during pregnancy<br/>28. Geriatric Emergency Surgery.

::Summary## This volume focuses on acute trauma to the adult elbow, including fractures, dislocations, tendon ruptures, and vascular and nerve injuries. Each chapter addresses anatomical key features, surgical and conservative therapeutic procedures, postoperative regimes and complication strategies. International elbow experts explore a range of surgical approaches, the usage of modern implants, advances in surgical techniques, and pearls and pitfalls for each trauma entity. Moreover, the authors describe total elbow arthroplasty and radial head replacement in detail, outline current clinical outcomes, and provide recommendations for therapeutic approaches and salvage measures. The book enables the orthopedic surgeon to deal with the entire spectrum of acute simple and complex elbow injuries in adults.<br/>::Contents##<br/>Part I. Simple elbow dislocations<br/>Part II. posteromedial rotatory instability<br/>Part III. Distal humerus fractures<br/>Part IV. Proximal ulna fractures<br/>Part V. Radial head fractures<br/>Part VI. Monteggia fractures<br/>part VII. Terrible triad injuries<br/>Part VIII. Distal biceps tendon rupture<br/>Part IX. Distal triceps tendon rupture<br/>Part X. Vascular injury<br/>Part XI. Nerve injury.

::Contents##<br/>Section I. Introduction<br/>Section II. Pathophysiology<br/>Section III. Diagnostic Strategy<br/>Section IV. Subtypes of Acute Encephalopathy<br/>Section V. Subtypes of Acute Encephalitis<br/>Section VI. Encephalopathy/Encephalitis With Refractory Epileptic Status: Rima Nabbout<br/>Section VII. Management of Acute Encephalopathy and Encephalitis.

::Summary## This book assembles recent achievements in both basic research and clinical management in the field of hepatology, virology and immunology. It provides up-to-date information for clinicians who can apply the relevant knowledge to their daily clinical practice and for researchers who are interested in clinically orientated studies. The updated and detailed technology, state-of–the-art treatment strategies provided in this book serve as references for clinicians and resident physicians in the daily management of ACLF. The rationality and strategies for basic research as well as patient management in this book can also be a valuable reference for other fatal and end stage liver diseases than HBV induced ACLF. This volume 1 has 6 chapters and focuses on the definition, research technology, virology, genetics, and immunology.<br/>::Contents##<br/>Introduction to Acute Exacerbation of Chronic Hepatitis B<br/>Research Technology and Principles of Clinical Study<br/>Virology<br/>Genetics<br/>Immunology.

::Contents##<br/>Section 1: Basics<br/>1. Pathophysiology of ischemic stroke<br/>2. Pathophysiology of moyamoya disease<br/>3. Radiological assessment of ischemic stroke<br/>4. Pathology of blood clot<br/>Section 2: Medical Practices<br/>5. General management & intensive care of ischemic stroke<br/>6. Cardiac evaluation and management after ischemic cerebral stroke<br/>7. Intravenous thrombolytic therapy<br/>8. Pediatric ischemic stroke<br/>Section 3: Endovascular Practices<br/>9. History and overview<br/>10. Clot aspiration technique<br/>11. Stent retriever technique<br/>12. Intracranial stenting<br/>13. Treatment of arterial dissection<br/>Section 4: Surgical Practices<br/>14. Surgical embolectomy<br/>15. Bypass surgery<br/>16. Decompressive hemicraniectomy.

::Contents##<br/>Acute kidney injury epidemiology : from recognition to intervention / Wang, Y., Fang, Y., Teng, J., Ding, X.<br/>Acute kidney injury prevention / Chopra, T.A., Brooks, C.H., Okusa, M.D.<br/>Renal recovery after acute kidney injury / Macedo, E., Mehta, R.L.<br/>Pathophysiology of septic acute kidney injury / Mårtensson, J., Bellomo, R.<br/>Biomarkers for diagnosis, prognosis and intervention in acute kidney injury / Fuhrman, D.Y., Kellum, J.A.<br/>The acute kidney injury to chronic kidney disease transition : a potential opportunity to improve care in acute kidney injury / Palant, C., Amdur, R., Chawla, L.S.<br/>Electronic data systems and acute kidney injury / Cheungpasitporn, W., Kashani, K.<br/>Fluid management in acute kidney injury / Chuang, C.-L.<br/>Multidimensional approach to adequacy of renal replacement therapy in acute kidney injury / Villa, G., Ricci, Z., Romagnoli, S., Ronco, C.<br/>Timing of renal replacement therapy in acute kidney injury / Ostermann, M., Wald, R., Bagshaw, S.M.<br/>Pediatric continuous renal replacement therapy / Ricci, Z., Goldstein, S.L.<br/>Management of cardiac surgery-associated acute kidney injury / Ding, X., Xu, J., Jiang, W., Fang, Y., Teng, J.

::Summary## This book presents up-to-date information on the clinical-pathophysiological features of acute renal injury and discusses the KDIGO diagnostic criteria, as well as novel experimental findings, including in the area of regenerative medicine. It also highlights the clinical-pathophysiological importance of AKI in clinical settings, including differential diagnoses and management of AKI. In the past, the pathology associated with sudden renal impairment was characterized as acute renal failure (ARF). However, in the 2000s, the joint efforts of specialists in fields including nephrology, intensive care medicine, and cardiovascular medicine led to the introduction of a novel concept known as acute kidney injury (AKI). As medical care progressed, patients such as high-risk elderly subjects who were not deemed to be candidates for invasive therapy came to be treated in intensive care units (ICUs). As a result, kidney injury as a subset of multiple organ failure was re-considered as AKI, especially in intensive care medicine. AKI was then proposed as a novel disease concept to emphasize the importance of early diagnosis and early intervention to improve prognosis. Presenting novel features, such as the definition of AKI, risk factors and management; biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL) and L-type fatty acid-binding protein (L-FABP); long-term outcomes of AKI; as well as renal regeneration using iPS cell, manipulation of embryonic genes, and Xenotransplanted embryonic kidney, this book is of interest to all physicians and researchers in this field around the globe.<br/>::Contents##<br/>Part 1 Diagnosis and risk factors of AKI<br/>Definition and epidemiology of AKI<br/>Cause of AKI (prerenal, renal, postrenal)<br/>Pathophysiology of AKI<br/>Diagnosis of AKI (clinical assessment, novel biomarkers)<br/>Risk factors for AKI development in surgery<br/>Risk factors for AKI development in heart failure<br/>7. Contrast-induced AKI<br/>8. Antibiotics- and immunosuppression-related AKI<br/>9. AKI in setting of cancer<br/>Community-acquired AKI and hospital-acquired AKI<br/>Part 2 Complication of AKI<br/>11. Complication of homeostasis (mineral and acid-base)<br/>12. Volume overload and cardiac and pulmonary complication<br/>Part 3 Prevention and management of AKI<br/>Prerenal and renal AKI<br/>Postrenal AKI<br/>AKI in intensive care medicine<br/>Nondialytic supportive management of AKI<br/>Renal replacement therapy in AKI<br/>Outcomes and long-term follow-up of AKI patients<br/>Prevention and management of pediatric AKI<br/>Part 4 Experimental novel findings<br/>AKI-to-CKD transition<br/>AKI and nerve system<br/>AKI and immune system<br/>AKI and cytokines<br/>Part 5 AKI and regenerative medicine<br/>iPS cell and renal regenerative medicine<br/>Embryonic genes and renal regenerative medicine<br/>Xenotransplanted embryonic kidney.

::Summary## The new edition of this well-received book provides a timely update of current knowledge on the biology, disease classification, and treatment of the acute leukemias - acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Throughout, the focus is on the provision of state of the art information and guidance that will meet the needs of clinicians. Chapters have been extensively revised to take into account advances in understanding and management that have been achieved over the past few years. In addition, new chapters have been included on selection of AML patients for therapy, a broader discussion of stem cell transplantation in AML, the role of immunotherapy in ALL, the approach to newly diagnosed pediatric ALL, and the diagnosis and management of BCR-ABL-like ALL. New therapies, including investigational ones, are fully covered. As progress continues in the management of acute leukemias this book will be a valuable asset for clinicians at all levels of experience.<br/>::Contents##<br/>Part I Acute Myeloid Leukemia<br/>Acute Myeloid Leukemia: Epidemiology and Etiology<br/>Clinical Presentation, Diagnosis and Classification of Acute Myedloid Leukemia<br/>Selection of Patients for Therapy<br/>Therapy of Newly Diagnosed AML<br/>Management of Relapsed and Refractory AML<br/>Stem cell Transplant in AML<br/>Investigational Therapies in AML<br/>Acute Lymphoblastic Leukemia<br/>Acute Lymphoblastic Leukemia: Epidemiology abnd Etiology<br/>Molecular Biology and Genetics<br/>Acute Lymphoblastic Leukemia: Clinical Presentation, Diagnosis, and Classification<br/>Therapy of Newly Diagnosed Adult ALL<br/>Approach to Newly Diagnosed Pediatric and AYA ALL<br/>The Role of Immunotherapy in ALL<br/>STem Cell Transplantation in the Treatment of ALL<br/>The Significance of Minimal Residual Disease in Acute Lymphoblastic Leukemia<br/>Philadelphia Chromosome<br/>Positive Acute Lymphoblastic Leukemia<br/>BCR-ABL-like ALL: Diagnosis and Management<br/>Burkitt's Acute Lymphoblastic Leukema in Adults<br/>Treatment of Lymphoblastic Lymphoma in Adults<br/>Central Nervous System Involovment in Adult Acute Lymphocytic Leukemia<br/>Management of Relapsed and Refractory ALL<br/>Emergencies in Acute Lymphoblastic Leukema<br/>Investigational Therapies in ALL.

::Summary## Acute Respiratory Distress Syndrome (ARDS) remains an important cause of morbidity and mortality worldwide, and the incidence is predicted to increase with the aging population Several clinical disorders can initiate ARDS, including pneumonia, sepsis, gastric aspiration and trauma but despite intense research over the past 40 years, we still have an incomplete understanding of the pathophysiology of the disease and treatment remains largely supportive. This book provides an overview of acute lung injury and repair, describes current animal models to study lung injury and reviews current methodologies to study and measure lung injury and repair. Special emphasis is given to state of the art techniques and methods and relevance to human disease. Acute Lung Injury and Repair: Scientific Fundamentals and Methods is a useful resource for physicians and scientists who are interested in experimental model systems for insight into ARDS pathogenesis and treatment strategies. ​

::Summary## Emergency General Surgery has become a cornerstone of Acute Care Surgery over the past decade. Once the scope of community general surgeons, the growing complexity of patients with acute surgical diseases has increasingly driven their care to tertiary referral centers. The aging population confounds this problem further as these patients present with more complex comorbidities, life-threatening physiology, and progressively severe anatomic disease severity. To ensure better outcomes, the practice has evolved to focus on evidence-based practice management guidelines in order to standardize care and optimize outcomes. This text provides a comprehensive volume for any surgeon who treats patients with acute surgical diseases. The first section is a comprehensive analysis of the background of Emergency General Surgery. The goal of this section is to provide the reader background into the acute surgical practice and to introduce the reader to the important concepts discussed in the remainder of the text. The second section discuss specific acute surgical diseases. Individual chapters outline the diagnostic approach, current treatment standards, operative approaches, and expected outcomes with an emphasis on practice management guideline implementation into practice. As acute surgical diseases and surgical critical care are integral to each other, the last section will be Critical Care for the Acute Care Surgeon. These topics focus on the critical care concepts essential to surgeons who care for acute diseases. This comprehensive text is targeted to any surgeon who takes emergency calls for any of the listed diseases including community and referral general and vascular surgeons. In addition, this would be an excellent resource for all general surgery residents. Lastly, this would also serve as a resource to intensivists who care for acute surgical patients.<br/>::Contents##<br/>History and Evolution of Emergency General Surgery<br/>Examination of the Acute Abdomen<br/>Development of the AAST Disease Severity Stratification System<br/>Infectious Disease Considerations<br/>Primer on Practice Management Guidelines<br/>Concepts in Emergency Research (Exception from Informed Consent)<br/>Inter-hospital Transfers of Emergency General Surgery Patients<br/>Emergency General Surgery as a Team Sport<br/>Small Bowel Obstruction<br/>Large Bowel Obstruction<br/>Abdominal Wall Hernias<br/>Acute Cholecystitis<br/>Appendicitis<br/>Acute Colonic Diverticulitis<br/>Intestinal Ischemia<br/>Perforated Peptic Ulcer<br/>Gastrointestinal Hemorrhage<br/>Complications of Acute Pancreatitis<br/>Acute and Chronic Enterocutaneous Fistula Management<br/>Soft Tissue Infection<br/>Perirectal Abscess<br/>Sepsis Resuscitation<br/>Hemorrhage Resuscitation<br/>Ventilator Management<br/>Nutrition Considerations<br/>Geriatrics and End of Life Care.

::Summary## "Acute Medicine offers an accessible and concise guide to the practical management of all acute medical problems likely to be encountered in the emergency department, ambulatory care centre, acute medical unit or on the wards. Reflecting the maturation of acute medicine as a separate specialty, the book is divided into common presentations, specific problems and procedures. New to the fifth edition is a chapter on bed-side ultrasonography; throughout, emphasis is placed on patient safety, and the use of flow diagrams, tables and figures ensures that key information is quickly accessible. Thoroughly revised by experts in the subject, and updated to reflect current approaches to diagnosis and management, Acute Medicine is an excellent companion for the trainee as well as an aide-mm̌oire for the more experienced physician"--Provided by publisher.<br/>::Contents##<br/>Presentations in Acute Medicine. The critically ill patient / Marlies Ostermann, David Sprigings<br/>Hypotension and shock / Marlies Ostermann, David Sprigings<br/>Reduced conscious level / Simon Rinaldi<br/>Delirium / David Sprigings<br/>Falls in older people / Simon Conroy, Oja Pathak<br/>Cardiac arrest in hospital / David Sprigings, John B Chambers<br/>Acute chest pain / John B Chambers, David Sprigings<br/>Palpitations / Sandeep Hothi, David Sprigings<br/>Transient loss of consciousness / Sandeep Hothi, David Sprigings<br/>Acute breathlessness / David Sprigings, John B Chambers<br/>Acute respiratory failure / Nayia Petousi<br/>Pleural effusion / Ioannis Psallidas<br/>Cough and haemoptysis / Ahmed Yousuf<br/>Neurological diagnosis in acute medicine / Simon Rinaldi<br/>Acute headache / Simon Rinaldi<br/>Seizures and epilepsy / Bridget MacDonald<br/>Weakness and paralysis / Simon Rinaldi<br/>Acute sensory symptoms / Simon Rinaldi<br/>Loss of vision / Tristan McMullan, David Sprigings<br/>Acute vomiting / Simon Anderson<br/>Acute abdominal pain / Simon Anderson<br/>Acute diarrhoea / Simon Anderson<br/>Acute jaundice / Ben Warner, Mark Wilkinson<br/>Ascites / Ben Warner, Mark Wilkinson<br/>Acute kidney injury / Marlies Ostermann, David Sprigings<br/>Acute rash / Nemesha Desai, Ruth Lamb<br/>Urticaria and angioedema / Alexandra Croom<br/>Acute arthritis / Kehinde Sunmboye<br/>Acute spinal pain / Michael Canty<br/>Acute limb pain / David Sprigings<br/>Comprehensive geriatric assessment / Simon Conroy, Oja Pathak<br/>Acute medical problems in pregnancy / Lucy Mackillop, Charlotte Frise<br/>Fever on return from abroad / Nick Beeching, Mike Beadsworth<br/>Acute medical problems in the HIV-positive patient / Mas Chaponda, Nick Beeching<br/>Syndromes and Disorders. Sepsis / Guy Glover, Manu Shankar-Hari<br/>Poisoning / Nigel Langford, David Sprigings<br/>Acid-base disorders / Nick Talbot<br/>Anaphylaxis / Alexandra Croom<br/>Acute arrhythmias: general principles of management / David Sprigings, John B Chambers<br/>Regular broad complex tachycardia / Michael Cooklin, David Sprigings<br/>Irregular broad complex tachycardia / Michael Cooklin, David Sprigings<br/>Narrow complex tachycardia / Michael Cooklin, David Sprigings<br/>Atrial fibrillation and flutter / Michael Cooklin, David Sprigings<br/>Bradycardia and atrioventricular block / Michael Cooklin, David Sprigings<br/>Acute coronary syndromes (1): ST-segment elevation / Jim Newton, John B Chambers<br/>Acute coronary syndromes (2): Non-ST-segment elevation / Jim Newton, John B Chambers<br/>Acute pulmonary oedema / David Sprigings, John B Chambers<br/>Acute heart failure and decompensated chronic heart failure / John B Chambers, David Sprigings<br/>Cardiogenic shock / John B Chambers, David Sprigings<br/>Aortic dissection and other acute aortic syndromes / John B Chambers<br/>Heart valve disease and prosthetic heart valves / John B Chambers<br/>Infective endocarditis / John B Chambers, John L Klein<br/>Acute pericarditis / David Sprigings, John B Chambers<br/>Cardiac tamponade / John B Chambers, David Sprigings<br/>Severe hypertension / David Sprigings, John B Chambers<br/>Deep vein thrombosis / Charlotte Masterton-Smith, Kevin O'Kane<br/>Pulmonary embolism / Roshan Navin, Kevin O'Kane<br/>Problems with pacemakers and other cardiac devices / Michael Cooklin, David Sprigings<br/>Upper airway obstruction / Matthew Frise<br/>Acute asthma / Swapna Mandal<br/>Exacerbation of chronic obstructive pulmonary disease (COPD) / Eui-Sik Suh<br/>Community-acquired pneumonia / Ahmed Yousuf<br/>Hospital-acquired pneumonia / Ahmed Yousuf<br/>Pneumothorax / Rob Hallifax<br/>Stroke / Tony Rudd, Ajay Bhalla<br/>Transient ischaemic attack / Ajay Bhalla, Tony Rudd<br/>Subarachnoid haemorrhage / Michael Canty<br/>Bacterial meningitis / David Sprigings, John L Klein<br/>Encephalitis / David Sprigings<br/>Spinal cord compression / Michael Canty<br/>Guillain-Barré syndrome / Simon Rinaldi<br/>Raised intracranial pressure / Michael Canty<br/>Acute upper gastrointestinal bleeding / Simon Anderson, Udi Shmueli<br/>Acute lower gastrointestinal bleeding / Sophia Savva, Andrew Dixon<br/>Acute oesophageal disorders / Sophia Savva, Andrew Dixon<br/>Inflammatory bowel disease flare / Sophia Savva, Andrew Dixon<br/>Acute liver failure and decompensated chronic liver disease / Ben Warner, Mark Wilkinson<br/>Alcoholic hepatitis / Ben Warner, Mark Wilkinson<br/>Biliary tract disorders and acute pancreatitis / Ben Warner, Mark Wilkinson<br/>Urinary tract infection / Carolyn Hemsley, Claire van Nispen tot Pannerden<br/>Hypoglycaemia / Vimal Venugopal, Vito Carone, Manohara Kenchaiah<br/>Hyperglycaemic states / Vimal Venugopal, Vito Carone, Manohara Kenchaiah<br/>Diabetic ketoacidosis / Vimal Venugopal, Vito Carone, Manohara Kenchaiah<br/>Hyperosmolar hyperglycaemic state / Vimal Venugopal, Vito Carone, Manohara Kenchaiah<br/>Disorders of plasma sodium concentration / James Crane, Paul Carroll, Martin Crook<br/>Disorders of plasma potassium concentration / Martin Crook<br/>Disorders of plasma calcium concentration / Martin Crook<br/>Disorders of plasma magnesium concentration / Martin Crook<br/>Disorders of plasma phosphate concentration / Martin Crook<br/>Acute adrenal insufficiency / James Crane, Paul Carroll<br/>Thyrotoxic storm / James Crane, Paul Carroll<br/>Myxoedema coma / James Crane, Paul Carroll<br/>Pituitary apoplexy / James Crane, Paul Carroll<br/>Paraganglioma (phaeochromocytoma) crisis / James Crane, Paul Carroll<br/>Cellulitis and necrotizing fasciitis / David Sprigings, John Klein<br/>Erythroderma and toxic epidermal necrolysis / Nemesha Desai, Seshi Manam<br/>Acute gout and pseudogout / Kehinde Sunmboye<br/>Septic arthritis / Kehinde Sunmboye, John L Klein<br/>Acute vasculitis / Raashid Luqmani<br/>Interpretation of full blood count and film / Claire Harrison<br/>Pancytopenia and febrile neutropenia / Deborah Hay<br/>Bleeding disorders / Claire Harrison<br/>Management of anticoagulation / Catherine Hildyard<br/>Acute painful sickle cell crisis / Jo Howard<br/>Complications of cancer / John B Chambers, Janine Mansi<br/>Alcohol-related problems in acute medicine / David Sprigings<br/>Hypothermia / David Sprigings<br/>Drowning / Francesca Garnham<br/>Electrical injury / Francesca Garnham, David Sprigings<br/>Palliative and end-of-life care / Louise Free<br/>Medicolegal issues in acute medicine / Tom Lloyd, Angelique Mastihi<br/>Techniques and Procedures in Acute Medicine. Airway management / Matthew Frise<br/>Non-invasive ventilation / Christopher Turnbull<br/>Ultrasonography in acute medicine / John B Chambers, Nadia Short, Luna Gargani<br/>Reading a chest X-ray / Ambika Talwar<br/>Central vein cannulation / Sandeep Hothi, David Sprigings<br/>Arterial blood sampling and cannulation / David Garry<br/>Arterial blood gases, oxygen saturation and oxygen therapy / David Sprigings<br/>Temporary cardiac pacing / Sandeep Hothi, David Sprigings<br/>Pericardial aspiration (pericardiocentesis) / Sandeep Hothi, David Sprigings<br/>DC cardioversion / Sandeep Hothi, David Sprigings<br/>Insertion of an intercostal chest drain / John Corcoran<br/>Lumbar puncture / Kannan Nithi<br/>Aspiration of the knee joint / Kehinde Sunmboye<br/>Insertion of a Sengstaken-Blakemore tube / Ben Warner, Mark Wilkinson.

::Summary## This book, written by a team of leading experts, provides a comprehensive overview of acute myeloid leukemia (AML), the most frequent acute leukemia in adults. The opening chapters present current knowledge of epidemiology, etiologic factors, and the pathogenesis and molecular development of AML. Detailed guidance is offered on laboratory and clinical diagnostic workup and disease classification, and the patient- and disease-related factors that determine prognosis and treatment allocation are identified. On the basis of these general considerations, initial treatments in patients considered fit for intensive treatment and in older and co-morbid patients are reviewed, and the available relapse treatment strategies, explained. For all clinical scenarios, the most recent data on the optimal use of newly approved agents in different AML subgroups are presented. Separate chapters address the treatment of acute promyelocytic leukemia, current practice of allogeneic stem cell transplantation, and special clinical situations. Finally, promising approaches in drug development, current standards and challenges in assessment of measurable residual disease, immune approaches, and ideas for innovative trial designs are considered.<br/>::Contents##<br/>1. Epidemiology and Etiology<br/>2. Diagnosis and Classification of AML: WHO 2016<br/>3. The Genomic Landscape and Clonal Evolution of AML<br/>4. Clinical Manifestation and Diagnostic Workup<br/>5. Prognostic Factors and Treatment Allocation<br/>6. Treatment of Acute Promyelocytic Leukemia<br/>7. Treatment of Newly Diagnosed AML in FitPatients<br/>8. Treatment of Newly Diagnosed AML in Unfit Patients<br/>9. Treatment of Relapsed and Refractory AML<br/>10. Allogeneic Stem Cell Transplantation<br/>11. Special Clinical Scenarios<br/>12. Future Developments.

::Summary## This practical guide provides the reader with answers to important clinically relevant questions regarding the evaluation and management of acute kidney injury (AKI). All aspects of critical care nephrology are covered, from pathophysiology and diagnosis to prevention and treatment. The questions considered relate to a wide range of issues, such as: How do I diagnose AKI? How can I protect the kidney in clinical practice? How do I manage patients with AKI? When should I initiate and how do I perform renal replacement therapy (RTT)? Which type of RTT is most appropriate for my patient? Should I give specific nutrients? In addition to providing practical guidelines and treatment algorithms, the book includes calculators for continuous RRT and anticoagulant dosing. The authors are internationally renowned experts in the fields of Intensive Care Medicine and Nephrology, and all contributions are written in a clear and concise style and have been peer reviewed. Acute Nephrology for the Critical Care Physician will serve as a very useful source for intensivists, internists, anesthesiologists, and nephrologists involved in the management and treatment of critically ill patients at risk of or affected by AKI.<br/>::Contents##<br/>1. Acute Kidney Injury (AKI): Definitions and clinical context (Z. Ricci)<br/>2. Epidemiology of AKI (E. Hoste)<br/>3. Pathophysiology of AKI: Ischemia/reperfusion, Sepsis/inflammation, Toxicity, Vascular (A.B.J. Groeneveld,)<br/>4. Diagnostic work-up of the patient with suspected AKI: Oliguria, Metabolic acidosis (J. Prowle)<br/>5. Uremic toxins (R. Vanholder)<br/>6. The kidney and other organs/conditions: Heart, Cardiorenal syndromes, Uremic pericarditis, Lungs/Asthma renale, Liver/Hepatorenal syndrome, Gut/Uremic mucositis/GI permeability, Brain, Coagulation, Pregnancy (S. Bagshaw)<br/>7. Biomarkers for AKI (M. Ostermann)<br/>8. Prevention of AKI and protection of the kidney: Fluids, Vasopressors, Inotropes and vasodilators, Anti-inflammatory treatment, Antioxidants; Prevention of contrast associate nephropathy (M. Joannidis, co-authors ICM paper)<br/>9. Timing of renal replacement therapy (RRT) in AKI (S. Bagshaw,)<br/>10. Dosing of RRT (C.S.C. Bouman)<br/>11. Types of RRT: Continuous vs. intermittent, Convection vs. diffusion, Predilution vs. Postdilution, SLED, Replacement fluids, Membranes, Biocompatability (L.G. Forni)<br/>12. Anticoagulation for RRT: Heparin, Citrate, HIT (H.M. Oudemans)<br/>13. Metabolic aspects of continuous renal replacement therapy (CRRT): Control of acidosis, Control of electrolytes, Bioenergetic gain and loss, Loss of (micro)nutrient, Nutrition (O. Joannes Boyeau)<br/>14. CRRT: in sepsis, after cardiac surgery (P. Honore)<br/>15. CRRT in the pediatric population (Z. Ricci)<br/>16. Drug removal by CRRT and drug dosing in the patient on CRRT (M. Schetz)<br/>17. CRRT for intoxications (D. Cruz)<br/>18. How to avoid harm in the patient with AKI: summary of key points of previous chapters (H.M. Oudemans)<br/>19. Follow-up and long-term renal outcomes of patients surviving AKI (J. Prowle).

::Summary## The book provides detailed information on all major neuroemergencies, and includes a detailed checklist for practical care during the first hour of an emergency. Reinforcing the concept of quality care for better outcomes in patients with neurological diseases, the book discusses approaches to comatose patients, neurological evaluation, neuropharmacology, neuroradiology, traumatic brain and spine injury, and various other neurological disorders. The field of neuroanesthesiology and neurocritical care has expanded with the advent of newer, complex surgeries, and neurocritical care is becoming an established subspecialty of neuroscience. Neurological emergencies require special care since prevention of secondary damage to the brain is of paramount importance. A valuable resource for intensivists, neurointensivists, emergency medicine physicians, neurology and neurosurgeons and nursing professionals involved in neurocare, this book also serves as study material for participants of the two-day course on "Acute Neuro Care" designed by the Indian Society of Neuroanesthesiology and Critical Care (ISNACC).<br/>::Contents##<br/>Intro<br/>Foreword<br/>Preface<br/>Contents<br/>About the Editors<br/>Abbreviations<br/>1: Airway and Breathing<br/>1.1 Introduction<br/>1.2 Rapid Airway Assessment<br/>1.2.1 Need for Tracheal Intubation<br/>1.2.2 Assessment of Airway for Difficult Ventilation and/or Intubation<br/>1.3 Intubation in an Unconscious Patient<br/>1.3.1 Step 1: Assess and Prepare<br/>1.3.2 Step 2: Open and Maintain Patency of the Airway<br/>1.3.3 Step 3: Preoxygenate for 3-5 min<br/>1.3.4 Step 4: Administer Induction Agent and Neuromuscular Blocking Agents 1.3.5 Step 5: Blunting Laryngoscopic Response Before Intubation<br/>1.3.6 Step 6: Tracheal Intubation<br/>1.3.6.1 Nasotracheal or Orotracheal Intubation?<br/>1.3.7 Step 7: Post-tracheal Intubation Care<br/>1.4 Management of Difficult Airway<br/>1.4.1 Basic Preparation for Difficult Airway Management<br/>1.4.2 Ensure Adequate Facemask Ventilation<br/>1.4.3 Improve the Chances of Successful Intubation<br/>1.5 Airway Management in Specific Neurological Emergencies<br/>1.5.1 Airway Management in Traumatic Head Injury<br/>1.5.2 Airway Management in Cervical Spine Injury 1.5.3 Airway Management in Neuromuscular Weakness<br/>1.5.4 Airway Management in Stroke<br/>1.6 Summary<br/>Multiple Choice Question<br/>References<br/>2: Approach to a Patient with Coma<br/>2.1 Introduction<br/>2.2 Coma<br/>2.3 Vegetative State<br/>2.4 Neurological Examination of the Comatose Patient<br/>2.4.1 Respiratory Pattern<br/>2.4.2 Pupillary Examination<br/>2.4.3 Motor Examination<br/>2.5 Causes of Coma<br/>2.5.1 Conditions Which Mimic Coma<br/>2.5.2 Approach to a Comatose Patient<br/>2.5.3 Investigations<br/>2.5.4 Laboratory Investigations<br/>2.5.5 Radiological Examination 2.6 Treatment of Coma<br/>2.6.1 Initial Management<br/>2.6.2 Coma Cocktail<br/>2.6.3 Outcome After Coma<br/>Multiple Choice Questions<br/>References<br/>3: Focused Neurological Evaluation<br/>3.1 Introduction<br/>3.2 Focused Clinical History<br/>3.3 General Survey and Clinical Examination<br/>3.4 Focused Neurological Examination<br/>3.4.1 Assessment of Level of Consciousness<br/>3.4.2 Fundoscopy and Pupillary Response<br/>3.4.3 Eye Movements<br/>3.4.4 Meningism<br/>3.4.5 Focal Neurological Deficits<br/>3.5 Common Neurological Emergencies and Its Clinical Presentations 3.6 Focused Neurological Examination of the Spinal Cord and Neuromuscular Disorders<br/>3.6.1 Acute Flaccid Paralysis (AFP)<br/>3.6.2 Acute Spastic Paralysis (Related to Spinal Cord)<br/>3.6.3 Spinal Cord Injury (SCI)<br/>3.7 Summary<br/>Multiple Choice Questions<br/>References<br/>4: Neuropharmacology<br/>4.1 Introduction<br/>4.2 Antiepileptic Drugs<br/>4.3 Sedatives and Analgesics<br/>4.4 Neuromuscular Blocking Drugs<br/>4.5 Intravenous Antihypertensive Agents<br/>4.6 Acetylcholinesterase Inhibitors in Myasthenia Gravis<br/>4.7 Drugs Used in Stroke<br/>4.7.1 Drugs Used in Revascularization for Acute Ischemic Stroke.

::Summary## This practical guide for trainees and advanced practice providers covers the essential management of hospitalized patients with acute neurologic conditions. Divided into five sections, this text serves as an incredibly easy-to-use, visually accessible, how-to manual that covers exactly what every responding clinician needs to know to care for the patient in front of them. The first section provides tangible guidance about how to pre-round, structure a presentation, examine neurologically ill patients, and interpret the core diagnostics obtained in many neurology patients: CT, MRI and EEG. The next three sections cover common complaints encountered in the hospital: spanning from non-vascular admissions, vascular & stroke neurology topics, and core neurocritical care principals and chief complaints. Throughout are checklists, scoring systems, pro-tips, images, helpful reminders, as well as concise summary of the pertinent literature. This is an ideal guide for medical students, neurology & neurosurgery trainees and advanced practice providers, as well as experienced professionals who want to brush up on the latest updates.<br/>::Contents##<br/>Part One: A Comprehensive "How-To" Guide<br/>Pre-Rounding On and Presenting Floor Patients. Pre-Rounding and Presenting NeuroICU Patients<br/>The Coma Exam<br/>Tips for Common Cranial Nerve Exam Findings<br/>Stroke and Vascular Anatomy<br/>Basics of Computed Tomography (CT)<br/>Basics of MRI Ordering and Assessment<br/>Understanding Transcranial Dopplers (TCDs)<br/>Tips and Tricks for EEG Interpretation<br/>Part Two: Vascular Neurology<br/>Acute Ischemic Stroke First Encounter Assessment and Management<br/>Perfusion Imaging<br/>Ischemic Stroke: Admission Checklist<br/>Stroke Workup Beyond the Basics<br/>Ischemic Stroke Dissection<br/>Ischemic Stroke - Symptomatic Carotid Stenosis "Hot Carotid" Ischemic Stroke Post Stroke Management of Anticoagulation<br/>Selected Anti-Platelets and Anticoagulation in Stroke Prevention<br/>Acute Management Strategies TPA and Mechanical Thrombectomy Trials<br/>Venous Sinus Thrombosis<br/>Posterior Reversible Vasoconstriction Syndrome (PRES) and Reversible Cerebral Vasoconstriction Syndrome (RCVS)<br/>Part Three: Non-Vascular Inpatient Neurology<br/>Altered Mental Status<br/>Framework for Workup of Unknown Brain "Lesion" Approach to First-Time Seizure<br/>Pharmacology Tips for Commonly Used AEDs Tips<br/>Approach to Infectious Encephalitis and Meningitis<br/>Aseptic Meningitis<br/>Inflammatory and Autoimmune Encephalitis<br/>Differential Diagnosis and Ordering Guide: Neuroanatomical Syndromes<br/>Autoimmune Encephalitis Testing<br/>Approach to New Onset Weakness<br/>Workup of New Demyelinating Lesions<br/>Approach to the "Dizzy" Patient<br/>Part Four: NeuroICU<br/>Intracranial Pressure: Theory and Management Strategies<br/>Management of External Ventricular Catheters<br/>Malignant Middle Cerebral Artery Infarction Intracerebral Hemorrhage Management<br/>Intracranial Hemorrhage LandmarkTrials<br/>Reversal of Selected Anti-Thrombotics<br/>An In-Depth Review of Reversing Direct Factor XA-Inhibitor-Related Hemorrhages<br/>Intracranial Hemorrhage - Management of Anticoagulation<br/>Subarachnoid Hemorrhage Differential<br/>Aneurysmal SAH Admission and Early Management<br/>Subarachnoid Hemorrhage Scoring Systems<br/>Aneurysmal SAH Daily Management Principles<br/>Subarachnoid Hemorrhage Notable Trials<br/>Traumatic Brain Injury.-Trials in TBI<br/>Induced Hypothermia after Cardiac Arrest<br/>Status Epilepticus<br/>Continuous EEG Monitoring, Electrographic Seizures and The Ictal-Interictal Continuum<br/>Neuromuscular Crises: ICU Management of Guillan Barr & Myasthenia Gravis<br/>Evaluation of C-Spine Trauma<br/>ICU Management of Spinal Cord Injuries<br/>Management of Post-Operative Craniotomy Patients<br/>Post-Operative Management of Cerebrovascular Patients<br/>Preparation for Brain Death Testing<br/>Nutrition in the NeuroICU<br/>Hypernatremia in the NeuroICU<br/>Hyponatremia in the NeuroICU<br/>Pressors and Inotropes Commonly Used in the NeuroICU Seizure Prophylaxis in the NeuroICU<br/>Venous Thromboembolism Prophylaxis in the NeuroICU<br/>Part Five: Important References<br/>Brainstem Anatomy NeuroICU Intravenous Fluid Compositions<br/>Anti-Epileptic Drug Chart, For Use in Adults<br/>Drug-Drug Interactions Common in Neuro Patients<br/>Myasthenia Gravis: Medications to Avoid<br/>Parkinsons Disease: Medications to Avoid.

::Summary## This book is the result of a convergence of scientific information regarding mechanisms that produce acute nerve cell death in the brain. Although seemingly disparate, stroke, brain and spinal cord trauma, coma from a low serum glucose concentration (hypoglycemia), and prolonged epileptic seizures have in common the inciting factor of excitotoxicity, the activation of a specific subtype of glutamate receptor by an elevated extracellular glutamate concentration that results in an excessive influx of calcium into nerve cells. The high calcium concentration in nerve cells activates several enzymes that are responsible for degradation of cytoplasmic proteins and cleavage of nuclear DNA, resulting in nerve cell death. The high calcium concentration also interferes with mitochondrial respiration, with the resultant production of free radicals that damage cellular membranes and nuclear DNA. Understanding the biochemical pathways that produce nerve cell death is the first step toward devising an effective neuroprotective strategy, the ultimate goal.<br/>::Contents##<br/>General considerations<br/>Traumatic brain injury<br/>Focal cerebral ischemia<br/>Transient global cerebral ischemia<br/>Hypoglycemic neuronal injury<br/>Seizure-induced neuronal death.

::Summary## This book provides recommendations for evaluation and therapy in the area of acute pediatric neurology; these are presented didactically with frequent use of illustrations and algorithms. Chapters in the first part of the book discuss presenting symptoms of acute neurological conditions. The second part of the book covers major areas of acute pediatric neurology and each of these chapters has three key elements: description of presenting symptoms; recommended assessments; and recommended interventions. Acute Pediatric Neurology provides an accessible, clinically focused guide to assist physicians in the emergency ward or intensive care unit in decisions on diagnosis and therapeutic interventions in all major acute pediatric neurological diseases.<br/>::Contents##<br/>Part 1: Acute Neurological Symptoms<br/>Unconsciousness, Coma, and Death by Neurological Criteria<br/>Seizures<br/>Acute Headache<br/>Acute Disturbance of Motor Function<br/>Acute Disturbance of Vision<br/>Dizziness and Vertigo<br/>Acute Changes of Behavior and Memory<br/>Part 2: Management of Acute Neurological Conditions<br/>Ischemic and Hypoxic Insults: Near Drowning, Asphyxia, Carbon Monoxide Poisoning<br/>Neurometabolic Crisis<br/>Approach to childhood-onset Muscle Cramps, Exercise Intolerance and Recurrent Myoglobinuria<br/>Management of Seizures and Status Epilepticus<br/>Management of Increased Intracranial Pressure<br/>Management of Migraine and Other Headaches<br/>Central Nervous System Infections (bacteria and parasites)<br/>Management of Acute Neuromuscular Disorders<br/>Stroke and Cerebrovascular Diseases<br/>Viral Infections, Autoimmune and Demyelinating Conditions of the Central Nervous System<br/>Spasticity, Dystonia, and Other Movement Disorders: A Comprehensive Treatment Guide<br/>Acute Pain.

::Contents##<br/>History of APL<br/>Molecular Targets of Treatment in APL<br/>The Leukemic Stem Cell<br/>The Molecular Genetics of APL<br/>APL Coagulopathy<br/>Early Death in APL<br/>Prognostic Factors in APL<br/>First-line therapy for APL: Chemotherapy-based approach<br/>First-line Therapy: ATRA-ATO/Reduced Chemotherapy Approach<br/>Cure of APL without Chemotherapy<br/>Minimal Residual Disease in APL<br/>Treatment of refractory and relapsed APL<br/>Hematopoietic Stem Cell Transplantation in APL<br/>APL in Children<br/>Management of APL in the Elderly<br/>Special Situations in APL<br/>APL in Developing Countries: A Chemotherapy-Based Approach<br/>APL in Developing Countries: ATO based Approach<br/>Therapy-Related APL<br/>Rare Acute Leukemia Variants involving Retinoic Acid Receptor Genes<br/>Management of Treatment-Related Complications in APL.

::Summary## This book covers all clinical aspects of acute respiratory distress syndrome (ARDS), from definition to treatment, focusing on the more recent recommendations and evidence-based medicine. The addressed topics are the various ventilation strategies, the impact of prone positioning, the use of partial and total extracorporeal support, the value of vasodilators, the weaning from mechanical ventilation, the pharmacological interventions, noninvasive ventilation, and the strategies using anti-inflammatory agents and stem cells. Furthermore, different related topics are also discussed, such as lung imaging, sedation, metabolic support, and hemodynamic instability. A concluding chapter specifically addresses ARDS in children. This up-to-date volume, written by experts in the field, will be of value for all health care practitioners seeking state of the art on the management of patients with this complex syndrome.

::Summary## Divided into thirteen chapters, this book provides a wealth of research-oriented findings and practical guidance, ranging from the definition, epidemiology and pathophysiology, to the diagnosis and management of the disease. Although acute respiratory distress syndrome (ARDS) is defined by the acute onset of noncardiogenic pulmonary edema, hypoxemia and the need for mechanical ventilation, it is a heterogeneous disease entity, which makes it difficult to develop specific therapies. Treatment tends to focus on lung-protective ventilation, and no specific pharmacotherapies have been identified. All chapters were written by respected experts in the field, and summarize the latest trends, share recent research findings, and outline future prospects. Specific chapters are devoted to novel, promising diagnostic approaches, such as microRNA, which may improve our ability to identify early ARDS or at-risk patients. In addition, a dedicated chapter explores cell-based therapies and regenerative medicine, which offer potential therapeutic options. Acute Respiratory Distress Syndrome - Advances in Diagnostic Tools and Disease Management offers a valuable reference guide not only for young physicians and trainees, but also for experienced or teaching physicians, medical educators, and basic researchers. Readers will find the latest information on ARDS and come to understand the current challenges, encouraging them to further advance the diagnosis, treatment and clinical research on this disease.

::Summary## Acute Rheumatic Fever and Rheumatic Heart Disease is a concise, yet comprehensive, clinical resource highlighting must-know information on rheumatic heart disease and acute rheumatic fever from a global perspective. Covering the major issues dominating the field, this practical resource presents sufficient detail for a deep and thorough understanding of the latest treatment options, potential complications, and disease management strategies to improve patient outcomes. Divided into four distinct sections for ease of navigation: Acute Rheumatic Fever, Rheumatic Heart Disease, Population-Based Strategies for Disease Control, and Acute and Emergency Presentations. International editors and chapter authors ensure a truly global perspective. Covers all clinical aspects, including epidemiology, pathophysiology, clinical features, diagnosis, management, and treatment. Includes key topics on population-based measures for disease control for effective primary, secondary, and tertiary prevention. Consolidates today's available information and guidance into a single, convenient resource.<br/>::Contents##<br/>Burden, cost, and epidemiology of acute rheumatic fever and rheumatic heart disease<br/>Pathogenesis of acute rheumatic fever<br/>Clinical evaluation and diagnosis of acute rheumatic fever<br/>Management of acute rheumatic fever<br/>Clinical evaluation and diagnosis of rheumatic heart disease<br/>Medical management of rheumatic heart disease<br/>Catheter-based investigation and treatment of rheumatic heart disease<br/>Surgical management of rheumatic heart disease<br/>Rheumatic heart disease in pregnancy<br/>Primordial and primary prevention prevention of ARF and RHD<br/>Secondary prevention of ARF and RHD<br/>Control programmes, registries, and access to care<br/>Rheumatic heart disease screening<br/>Group A streptococcal vaccine<br/>Advocacy and education<br/>Acute complications and Emergencies of ARF and RHD.

::Summary## This book provides clear guidance on how to manage a wide range of side effects frequently encountered when treating patients with radiation therapy. For each potential side effect, incidence, mechanism, symptoms, and grading are carefully described. All aspects of management are addressed, drawing on the latest available evidence and highlighting key details of importance in clinical routine. The introduction of new radiation therapy techniques such as 3D conformal radiation therapy, intensity-modulated radiation therapy, and image-guided radiation therapy has reduced normal tissue doses and, accordingly, treatment complications. Nevertheless, a significant percentage of patients still experience acute side effects, in part because the threshold doses for these toxicities are typically lower than those for late effects. Acute toxicities may lead to interruption of treatment and be associated with an increase in late damage. A swift and effective response is therefore essential. This book will enable the reader to provide effective care for each side effect, thereby improving patient compliance with treatment and treatment outcomes.

::Summary## You have just encountered a possible stroke patient. You ask yourself: what should I do first? How do I know it is a stroke? Is it too late to reverse the damage? This book provides integral assistance in answering these critical questions. All content is arranged in chronological order, covering all considerations in assessing and treating patients in the emergency room, stroke unit, and rehabilitation facilities. This new edition offers readers the latest information on stroke treatment, and features brand new chapters on stroke radiology, endovascular therapy, the uncommon causes of stroke, cerebral venous thrombosis, stroke prevention, and the transition to outpatient care. The comprehensive set of appendices contains useful reference information, including dosage algorithms, conversion factors, and stroke scales.<br/>::Contents##<br/>Stroke in the emergency department<br/>What to do first<br/>Ischemic stroke<br/>Stroke radiology<br/>Intravenous thrombolysis<br/>Endovascular therapy (ET)<br/>Neurological deterioration in acute ischemic stroke<br/>Ischemic stroke etiology and secondary prevention<br/>Transient ischemic attack (TIA)<br/>Less common causes of stroke<br/>Cerebral venous sinus thrombosis<br/>Intracerebral hemorrhage (ICH)<br/>Subarachnoid hemorrhage (SAH)<br/>Organization of stroke care<br/>Stroke rehabilitation<br/>Transition to outpatient stroke care.

::Summary## This book contains a compilation of the revolution of mechanical thrombectomy (MT) in the treatment of strokes. The initial chapters summarize information about the best medical management of acute ischemic stroke, imaging modalities and patient selection for MT. The book then focuses on the nuances of MT, providing detailed information about the best approaches for anesthesia during MT, access, intra-arterial thrombolysis, recent devices and catheters and technical pitfalls of MT. A specific chapter is dedicated to MT in the venous system. This is followed by a chapter about the most common complications of MT and post-procedural care of these patients. The last chapter covers different aspects of acute stroke care and MT in the developing world. The authors of this book comprise of a multidisciplinary group of world experts in the field and were encouraged to include teaching cases to deliver a book with a practical approach. Acute Stroke Management in the Era of Thrombectomy is intended for all healthcare providers who care for patients with stroke; with special emphasis for the proceduralists who are interested in technical tips to improve outcomes and minimize complications.<br/>::Contents##<br/>Best Medical Management for Acute Ischemic Stroke<br/>Imaging of Acute Ischemic Stroke<br/>Indications for Mechanical Thrombectomy<br/>Anesthesia During Endovascular Treatment of Acute Ischemic Stroke<br/>Arterial Access and Intermediate Catheters: Procedural and Technical Considerations<br/>Intra-arterial Thrombolytics for Treatment of Acute Ischemic Stroke<br/>Mechanical Thrombectomy: Emerging Devices and Technologies<br/>Mechanical Thrombectomy: Techniques and Hybrid Approaches for Recanalization<br/>Acute Stenting During Acute Ischemic Stroke<br/>Tandem Occlusion Causing Acute Ischemic Stroke<br/>Mechanical Thrombectomy in Distal Vessels: M2s and Beyond<br/>Thrombectomy of the Posterior Circulation: Tips and Tricks<br/>Thrombectomy in the Venous System: Approaches and Techniques<br/>Complications During Mechanical Thrombectomy: Pitfalls and Bailouts<br/>Post-operative Care After Mechanical Thrombectomy<br/>Stroke-Care and Mechanical Thrombectomy in Developing Countries.

::Summary## This book aims to familiarize readers with the most common acute surgery topics encountered in clinical practice and is unique in its use of infographics. It will be used in clinical rotations in surgery as a supplement to the knowledge gained, and will also provide instructors with a complementary tool, offering a wide-ranging guide to general aspects of acute surgery, with some hints on gynecologic and urologic emergencies. The book is intended to provide medical students and junior residents in medicine or surgery with a comprehensive and up-to-date overview of the most relevant operative techniques.<br/>::Contents##<br/>Preoperative Labs And Tests<br/>Preoperative Cardiac Evaluation<br/>Preoperative Pulmonary Evaluation<br/>The Abc's of Medical Imaging<br/>Appendicitis<br/>Acute Cholecystopathy<br/>Acute Pancreatitis<br/>Acute Diverticulitis<br/>Small Bowel Obstruction<br/>Large Bowel Obstruction (Lbo)<br/>Clostridioides Difficile Colitis<br/>Upper Gastroitestinal Bleeding<br/>Lower Gastrointestinal Bleeding<br/>Variceal Bleeding<br/>Caustic Ingestion<br/>Neutropenic Enterocolitis<br/>Acute Mesenteric Ischemia<br/>Ruptured Abdominal Aortic Aneurysm<br/>Aortic Dissection<br/>Peripheral Arterial Embolism<br/>Hypercoagulability<br/>Bleeding Disorders.

::Contents##<br/>Brief introduction to the history of anti-doping / Ljungqvist, A.<br/>The development of the world anti-doping code / Young, R.<br/>Is the fight against doping in sport a legal minefield like any other? / Haas, U.<br/>How will the legal and sport environment influence a future code? / Niggli, O.<br/>Structure and development of the list of prohibited substances and methods / Kinahan, A.; Budgett, R.; Mazzoni, I.<br/>Therapeutic use exemptions / Gerrard, D.; Pipe, A.<br/>Challenges in modern anti-doping analytical science / Ayotte, C.; Miller, J.; Thevis, M.<br/>Achievements and challenges in anti-doping research / Bowers, L.D.; Bigard, X.<br/>Gene and cell doping : the new frontier : beyond myth or reality / Neuberger, E.W.I.; Simon, P.<br/>The athlete biological passport : how to personalize anti-doping testing across an athlete's career? / Robinson, N.; Sottas, P.-E.; Schumacher, Y.O.<br/>Next generation "omic" approaches in the "fight" against blood doping / Wang, G.; Karanikolou, A. ; Verdouka, I.; Friedmann, T.; Pitsiladis, Y.<br/>Integration of the forensic dimension into anti-doping strategies / Marclay, F.; Saugy, M.<br/>How to develop intelligence gathering in efficient and practical anti-doping activities / Holz, M; Robertson, J.<br/>Education in anti-doping: the art of self-imposed constraints / Loland, S.<br/>Can we better integrate the role of anti-doping in sports and society? : a psychological approach to contemporary value-based prevention / Petróczi, A. ; Norman, P.; Brueckner, S.<br/>Sport, society, and anti-doping policy : an ethical overview / Bloodworth, A.J.; McNamee, M.<br/>A moral foundation for anti-doping : how far have we progressed? where are the limits? / Murray, T.H.<br/>Conclusion and perspectives / Howman, D.

::Contents##<br/>Accessible Routes<br/>Site Elements<br/>Vertical Access<br/>Architectural Elements<br/>Restrooms & Bathing Facilities<br/>Other Elements<br/>A Word or Two on Existing Projects<br/>Innovative Ideas on Access World-Wide.

::Summary## "This clinically oriented book gives dental practitioners and students a hands-on guide to incorporating dental implants into their practices. Taking a clear and concise approach to the subject, the book offers basic information on all aspects of dental implants. Topics covered encompass the pros and cons of implants, patient factors, clinical considerations to success and failure, and implant restoration. Photographs, radiographs, and illustrations support the text, demonstrating the concepts discussed. The ADA Practical Guide to Dental Implants starts with a brief history of the subject then examines the clinical and economic considerations for implants. Patient factors, including systemic, oral, and periodontal health, diet, age, gender, and more are discussed. The book also looks at the experience of the clinician, followed by clinical considerations such as case planning, implant design, surgical techniques, antibiotics, and more. The last chapters cover post-surgical follow-up and the many factors that lead to a successful outcome. The ADA Practical Guide to Dental Implants is a useful introduction and guide to dental implants for any practitioner interested in incorporating implants into clinical practice"-- Provided by publisher.<br/>::Contents##<br/>Why dental implants<br/>A brief history of dental implants<br/>Design of Implants<br/>Patient factors<br/>Patient consults<br/>Treatment planning and Evaluating implant sites<br/>Implant scenarios<br/>Implant surgery: simple healed sites<br/>Bone grafting<br/>Guided surgery<br/>Immediate implant placement: complicated immediate sites<br/>Full arch cases<br/>Screw-retention vs. Cement-retention of restorations<br/>Restoring dental implants<br/>Dental implant failures<br/>Economics of dental implants<br/>Maintaining dental implants.

::Contents##<br/>The extraoral and intraoral soft tissue head and neck screening examination<br/>Soft tissue head and neck pathology description and documentation<br/>Common oral soft tissue lesions<br/>Differential diagnosis of common oral soft tissue lesions<br/>Guidelines for observation and/or referral of patients lesions<br/>The art and science of biopsy and cytology<br/>Sample patient histories and discussion.

::Contents##<br/>Ch. 1. Approach to the patient with neurologic disease<br/>Ch. 2. Imaging, electrophysiologic, and laboratory techniques for neurologic diagnosis<br/>Ch. 3. Motor paralysis<br/>Ch. 5. Ataxia and disorders of cerebellar function<br/>Ch. 6. Tremor, myoclonus, focal dystonias, and tics<br/>Ch. 7. Disorders of stance and gait<br/>Ch. 10. Headache and other craniofacial pains<br/>Ch. 11. Pain i n the back, neck, and extreities<br/>Ch. 12. Disorders of smell and taste<br/>Ch. 13. Disturbances of vision<br/>Ch. 14. Disorders of ocular movement and pupillary function<br/>Ch. 15. Deafness, dizziness, and disorders of equilibrium<br/>Ch. 16. Epilepsy and other seizure disorders<br/>Ch. 17. Coma and related disorders of consciousness<br/>Ch. 18. Faintness and syncope<br/>Ch. 19. Sleep and its abnormalities<br/>Ch. 20. Delirium and other acute confusional states.

::Summary## "The definitive text on the full spectrum of neurology presented in full color and better than ever! Long considered the field's gold-standard text, Adams and Victor's Principles of Neurology provides the very latest treatment and management strategies needed to confidently handle both common and rare neurologic conditions. Presented in full color, this classic resource meets the needs of the seasoned professional or the aspiring clinician, and has been hailed as the most detailed, thorough, and authoritative text on the subject. Reviewers have favorably compared the book's consistent, single voice to consulting with an experienced senior colleague. The latest scientific research is included in just the right amount of detail to serve as a clinical reference or a starting point for additional learning. The text is logically divided into six sections: The Clinical Method of Neurology; Cardinal Manifestations of Neurologic Disease; Growth and Development of the Nervous System in the Neurology of Aging; Major Categories of Neurologic Diseases; Diseases of the Spinal Cord, Peripheral Nerve, and Muscle; Psychiatric Disorders"-- Provided by publisher. "The wise application of science, evidence from trials, and the traditional virtues of the neurological history and examination are the main purpose of this edition of Principles of Neurology"-- Provided by publisher.<br/>::Contents##<br/>PART 1: THE CLINICAL METHOD OF NEUROLOGY<br/>Chapter 1: Approach to the Patient With Neurologic Disease<br/>Chapter 2: Diagnostic Testing in Neurologic Disease<br/>PART 2: CARDINAL MANIFESTATIONS OF NEUROLOGIC DISEASE<br/>Part 2: Cardinal Manifestations of Neurologic Disease: Introduction<br/>Section 1: Disorders of Motility<br/>Section 1: Disorders of Motility: Introduction<br/>Chapter 3: Paralysis and Weakness<br/>Chapter 4: Disorders of Movement and Posture<br/>Chapter 5: Ataxia and Disorders of Cerebellar Function<br/>Chapter 6: Disorders of Stance and Gait<br/>Section 2: Pain and Disorders of Somatic Sensation<br/>Section 2: Pain and Disorders of Somatic Sensation: Introduction<br/>Chapter 7: Pain<br/>Chapter 8: Disorders of Non-Painful Somatic Sensation<br/>Chapter 9: Headache and Other Craniofacial Pains<br/>Chapter 10: Pain in the Back, Neck, and Extremities<br/>Section 3: Disorders of the Special Senses<br/>Section 3: Disorders of the Special Senses: Introduction<br/>Chapter 11: Disorders of Smell and Taste<br/>Chapter 12: Disturbances of Vision<br/>Chapter 13: Disorders of Ocular Movement and Pupillary Function<br/>Chapter 14: Deafness, Dizziness, and Disorders of Equilibrium<br/>Section 4: Epilepsy and Disorders of Consciousness<br/>Chapter 15: Epilepsy and Other Seizure Disorders<br/>Chapter 16: Coma and Related Disorders of Consciousness<br/>Chapter 17: Faintness and Syncope<br/>Chapter 18: Sleep and Its Abnormalities<br/>Section 5: Derangements of Intellect, Behavior, and Language Caused by Diffuse and Focal Cerebral Disease<br/>Section 5: Derangements of Intellect, Behavior, and Language Caused by Diffuse and Focal Cerebral Disease: Introduction<br/>Chapter 19: Delirium and Other Acute Confusional States<br/>Chapter 20: Dementia, the Amnesic Syndrome, and the Neurology of Intelligence and Memory<br/>Chapter 21: Neurologic Disorders Caused by Lesions in Specific Parts of the Cerebrum<br/>Chapter 22: Disorders of Speech and Language<br/>Section 6: Disorders of Energy, Mood, and Autonomic and Endocrine Functions<br/>Chapter 23: Fatigue, Asthenia, Anxiety, and Depression<br/>Chapter 24: The Limbic Lobes and the Neurology of Emotion<br/>Chapter 25: Disorders of the Autonomic Nervous System, Respiration, and Swallowing<br/>Chapter 26: The Hypothalamus and Neuroendocrine Disorders<br/>PART 3: GROWTH AND DEVELOPMENT OF THE NERVOUS SYSTEM AND THE NEUROLOGY OF AGING<br/>Chapter 27: Normal Development and Deviations in Development of the Nervous System<br/>Chapter 28: The Neurology of Aging<br/>PART 4: MAJOR CATEGORIES OF NEUROLOGIC DISEASE<br/>Chapter 29: Disturbances of Cerebrospinal Fluid, Including Hydrocephalus, Pseudotumor Cerebri, and Low-Pressure Syndromes<br/>Chapter 30: Intracranial Neoplasms and Paraneoplastic Disorders<br/>Chapter 31: Bacterial, Fungal, Spirochetal, and Parasitic Infections of the Nervous System<br/>Chapter 32: Viral Infections of the Nervous System and Prion Diseases<br/>Chapter 33: Stroke and Cerebrovascular Diseases<br/>Chapter 34: Craniocerebral Trauma<br/>Chapter 35: Multiple Sclerosis and Other Inflammatory Demyelinating Diseases<br/>Chapter 36: Inherited Metabolic Diseases of the Nervous System<br/>Chapter 37: Developmental Diseases of the Nervous System<br/>Chapter 38: Degenerative Diseases of the Nervous System<br/>Chapter 39: The Acquired Metabolic Disorders of the Nervous System<br/>Chapter 40: Diseases of the Nervous System Caused by Nutritional Deficiency<br/>Chapter 41: Disorders of the Nervous System Caused by Alcohol, Drugs, Toxins, and Chemical Agents<br/>PART 5: DISEASES OF SPINAL CORD, PERIPHERAL NERVE, AND MUSCLE<br/>Chapter 42: Diseases of the Spinal Cord<br/>Chapter 43: Diseases of the Peripheral Nerves<br/>Chapter 44: Diseases of the Cranial Nerves<br/>Chapter 45: Diseases of Muscle<br/>Chapter 46: Disorders of the Neuromuscular Junction, Myotonias, and Persistent Muscle Fiber Activity<br/>PART 6: PSYCHIATRIC DISORDERS<br/>Chapter 47: Anxiety Disorders, Hysteria, and Personality Disorders<br/>Chapter 48: Depression and Bipolar Disease<br/>Chapter 49: Schizophrenia, Delusional, and Paranoid States.

::Summary## "Adams and Victor’s Principles of Neurology provides up to date treatment and management strategies needed to confidently handle both common and rare neurologic conditions. Presented in full color, this enduring resource meets the needs of today’s aspiring clinician or seasoned professional, and has been hailed as the most detailed, thorough, and authoritative text on the subject"-- Publisher's description.<br/>::Contents##<br/>Part 1: The clinical method of neurology. Approach to the patient with neurologic disease<br/>Diagnostic testing in neurologic disease<br/>Part 2: Cardinal manifestations of neurologic disease. Section 1: Disorders of motility. Paralysis and weakness<br/>Disorders of movement and posture<br/>Ataxia and disorders of cerebellar function<br/>Disorders of stance and gait<br/>Section 2: Pain and disorders of somatic sensation. Pain<br/>Disorders of non-painful somatic sensation<br/>Headache and other craniofacial pains<br/>Pain in the back, neck, and extremities<br/>Section 3: Disorders of the special senses. Disorders of smell and taste<br/>Disturbances of vision<br/>Disorders of ocular movement and pupillary function<br/>Deafness, dizziness, and disorders of equilibrium<br/>Section 4: Epilepsy and disorders of consciousness. Epilepsy and other seizure disorders<br/>Coma and related disorders of consciousness<br/>Faintness and syncope<br/>Sleep and its abnormalities<br/>Section 5: Derangements of intellect, behavior, and language caused by diffuse and focal cerebral disease. Acute confusional states<br/>Dementia, the amnesic syndrome, and the neurology of intelligence and memory<br/>Neurologic disorders caused by lesions in specific parts of the cerebrum<br/>Disorders of speech and language<br/>Section 6: Disorders of energy, mood, and autonomic and endocrine functions. Fatigue, asthenia, anxiety, and depression<br/>The limbic lobes and the neurology of emotion<br/>Disorders of the autonomic nervous system, respiration, and swallowing<br/>The hypothalamus and neuroendocrine disorders<br/>Part 3: Growth and development of the nervous system and the neurology of aging. Normal development and deviations in development of the nervous system<br/>The neurology of aging<br/>Part 4: Major categories of neurologic disease. Disturbances of cerebrospinal fluid, including hydrocephalus, pseudotumor cerebri, and low-pressure syndromes<br/>Intracranial neoplasms and paraneoplastic disorders<br/>Bacterial, fungal, spirochetal, and parasitic infections of the nervous system<br/>Viral infections of the nervous system and prion diseases<br/>Stroke and cerebrovascular diseases<br/>Craniocerebral trauma<br/>Multiple sclerosis and other neuroimmunologic disorders<br/>Inherited metabolic diseases of the nervous system<br/>Developmental diseases of the nervous system<br/>Degenerative diseases of the nervous system<br/>The acquired metabolic disorders of the nervous system<br/>Diseases of the nervous system caused by nutritional deficiency<br/>Disorders of the nervous system caused by alcohol, drugs, toxins, and chemical agents<br/>Part 5: Diseases of spinal cord, peripheral nerve, and muscle. Diseases of the spinal cord<br/>Diseases of the peripheral nerves<br/>Diseases of the cranial nerves<br/>Diseases of muscle<br/>Disorders of the neuromuscular junction, myotonias, and disorders of persistent muscle fiber activity<br/>Part 6: Psychiatric disorders. Anxiety, "functional" and personality disorders<br/>Depression and bipolar disorder<br/>Psychosis, schizophrenia, delusional, and paranoid states.

::Summary## This book highlights state-of-the-art research and practices for adaptation to climate change in food production systems (agriculture in particular) as observed in Japan and neighboring Asian countries. The main topics covered include the current scientific understanding of observed and projected climate change impacts on crop production and quality, modeling of autonomous and planned adaptation, and development of early warning and/or support systems for climate-related decision-making. Drawing on concrete real-world examples, the book provides readers with an essential overview of adaptation, from research to system development to practices, taking agriculture in Asia as the example. As such, it offers a valuable asset for all researchers and policymakers whose work involves adaptation planning, climate negotiations, and/or agricultural developments.<br/>::Contents##<br/>Part I. Introduction<br/>Chapter 1. An overview of adaptation in agriculture<br/>Part II. Research towards adaptation<br/>Chapter 2. The quality of rice grains in Japan<br/>Chapter 3. Breeding of heat tolerant cultivars of rice in Japan<br/>Chapter 4. Controlling the depth of soil frost in farm fields in Japan<br/>Chapter 5. Rice production in Indonesia<br/>Chapter 6. Tomato greenhouse horticulture<br/>Chapter 7. Global crop forecasting research<br/>Chapter 8. China<br/>Part III. Adaptation practices<br/>Chapter 9. Agricultural adaptation policy in Japan<br/>Chapter 10. Information platform for local governments in Japan<br/>Chapter 11. Supporting tools for national adaptation planning<br/>Chapter 12. Use of seasonal climate forecasts in agricultural decision makings in Korea and the Philippines<br/>Chapter 13. Decision support systems for rainfed rice farming in Asia<br/>Part IV. Potential ways moving forward<br/>Chapter 14. Farmers roles in adaptation research.

::Contents##<br/>1. The Inductive Agency of Stress: From Perinatal to Adolescent Induction / Trevor Archer and Richard M. Kostrzewa<br/>Part I. Introductory Concepts<br/>2. Making Sense of Stress: An Evolutionary-Developmental Framework / Marco Del Giudice, Bruce J. Ellis, and Elizabeth A. Shirtcliff<br/>3. Prenatal and Maternal Psychosocial Stress in Primates: Adaptive Plasticity or Vulnerability to Pathology? / Dario Maestripieri and Amanda C.E. Klimczuk<br/>Part II. Adaptive and Maladaptive Consequences of Developmental Stress In Humans<br/>4. The Everyday Stress Resilience Hypothesis: Unfolding Resilience from a Perspective of Everyday Stress and Coping / Jennifer A. DiCorcia, Akhila V. Sravish, and Ed Tronick<br/>5. Ontogeny of Stress Reactivity in the Human Child: Phenotypic Flexibility, Trade-Offs, and Pathology / Mark V. Flinn, Davide Ponzi, Pablo Nepomnaschy, and Robert Noone<br/>6. Consequences of Developmental Stress in Humans: Prenatal Stress / Nadine Skoluda and Urs M. Nater<br/>7. Consequences of Developmental Stress in Humans: Adversity Experienced During Childhood and Adolescence / Urs M. Nater and Nadine Skoluda<br/>Part III. Adaptive and Maladaptive Consequences of Developmental Stress in Animal Models<br/>8. Behavioural and Neuroendocrine Consequences of Prenatal Stress in Rat / Sara Morley-Fletcher, Jérôme Mairesse, and Stefania Maccari<br/>9. Developmental Consequences of Prenatal Administration of Glucocorticoids in Rodents and Primates / Jonas Hauser<br/>10. Early Developmental Trajectories of Brain Development: New Directions in the Search for Early Determinants of Health and Longevity / F. Cirulli and A. Berry<br/>11. Adaptive Regulations in Developing Rodents Following Neonatal Challenges / Laurence Coutellier<br/>12. Adaptive and Maladaptive Regulations in Response to Environmental Stress in Adolescent Rodents / Simone Macrì and Giovanni Laviola<br/>13. Oxidative Stress and Hormetic Responses in the Early Life of Birds / David Costantini.

::Summary## The Addiction Casebook consists of 13 clinical cases that exemplify DSM-5 addiction diagnoses commonly encountered in clinical practice. Written in an engaging, easy-to-understand manner, the book complements substance abuse textbooks by providing hands-on experience with real-life situations and updated information relating to DSM-5® diagnoses.<br/>::Contents##<br/>Cover; Contents; Contributors; Preface; Part I. Introduction; 1 DSM-5 Criteria for Substance Use Disorders: Recommendations and Rationale; Part II. Substance-Related Disorders; 2 Alcohol: Conundrums of Co-occurring Disorders; 3 Caffeine: The Ins and Outs of Caffeine; 4 Cannabis: A Natural Dilemma; 5 Hallucinogens: The Mind Field of Oswald: A Case of Hallucinogen Intoxication; 6 Inhalants: Just say N[sub(2)]O!; 7 Opioids: Finding the Off Switch; 8 Sedatives, Hypnotics, or Anxiolytics: Sleepless Nights and the Magic Pills. 9 Stimulants: Sex, Drugs, and Techno: Gay Men and Crystal Methamphetamine10 Tobacco: From Social Norm to Modern Day Faux Pas; 11 Other (or Unknown) Substances: The Brave New World of Bath Salts and Other Synthetic Drugs; Part III. Non-Substance-Related Disorder; 12 Gambling: The Woman Who Became Tired of Trying to Predict the Future; Part IV. Condition for Further Study; 13 Internet: Why Are Drug Addicts and People Who Use the Internet Both Called "Users?"; Index; A; B; C; D; E; F; G; H; I; K; L; M; N; O; P; R; S; T; U; V; W; X; Z.

::Summary## An evidence-based review of diagnostic and treatment strategies for successfully managing alcohol and substance use disorders in older adults. With contributions from leaders in the field of addiction treatment, this volume offers the most current clinical recommendations and describes best practices for implementing effective treatments in this growing patient population.<br/>::Contents##<br/>Introduction / Maria Sullivan, Frances R. Levin<br/>Recognizing addiction in older patients / Anna Levesque, Edward Nunes<br/>Brief interventions for substance use disorder in older adults / Roland C. Merchant, Francesca L. Beaudoin<br/>Alcohol and older adults / Anna Terajewicz LaRose, John Renner<br/>Abuse of opioids and prescription medications / Isis Burgos-Chapman, Louis Trevisan, Kevin Sevarino<br/>Cannabis, nicotine, and stimulant abuse in older adults / Isis Burgos-Chapman, Louis Trevisan, Kevin Sevarino<br/>Benzodiazepines and other sedative-hypnotics in the older adult / Arthur Robin Williams, Olivera J. Bogunovic<br/>Assessment of the older patient / Arthur Robin Williams, Olivera J. Bogunovic<br/>Sex differences in late-life substance use disorders / Elizabeth Evans, Maria Sullivan<br/>Treatment options for older adults with substance use disorders / Stacy A. Cohen, Margaret M. Haglund, Larissa J. Mooney<br/>Technology-based interventions for late-life addiction Ersa Alagoz, Kim Johnson, Andrew Quanbeck, David Gustafson Jr.<br/>Conclusion / Maria Sullivan.

::Contents##<br/>1. The nature of addictive disorders / John B. Saunders<br/>2. Epidemiology and prevention / Peter Anderson, Katherine M. Conigrave, Louisa Degenhardt, Wayne Hall, and Tim Stockwell<br/>3. Pharmacology and pathophysiology / Kazutaka Ikeda, Daisuke Nishizawa, David J. Nutt, and John B. Saunders<br/>4. The scope of intervention / Sawitri Assanangkornchai and John B. Saunders<br/>5. Establishing the diagnosis / Glenys Dore, Noeline C. Latt, and John B. Saunders<br/>6. Acute care / Glenys Dore, Noeline C. Latt, E. Jane Marshall, John B. Saunders, and Peter Thompson<br/>7. Ongoing management of substance use disorders / Stephen Jurd and John B. Saunders<br/>8. Tobacco / Renee Bittoun, Katherine M. Conigrave, Hisatsugu Miyata, and Nicholas Zwar<br/>9. Alcohol / Robert Batey, Katherine M. Conigrave, Colin Drummond, Noeline C. Latt, E. Jane Marshall, David J. Nutt, Richard Saitz, and John B. Saunders<br/>10. Cannabis / H. Valerie Curran, Margaret Haney, David J. Nutt, and John B. Saunders<br/>11. Opioids / Robert Batey, Katherine M. Conigrave, Noeline C. Latt, David J. Nutt, John B. Saunders, Andrew J. Saxon, and George Woody<br/>12. Pain and opioids / James Bell<br/>13. Benzodiazepines and the other sedative-hypnotics / Noeline C. Latt, David J. Nutt, and John B. Saunders<br/>14. Psychostimulants / Glenys Dore, Walter Ling, and David J. Nutt<br/>15. Hallucinogens and dissociative drugs / David J. Nutt and Adam R. Winstock<br/>16. Other drugs / Jenny Bearn, Jonathan Brett, Adam Brodie, Katherine M. Conigrave, Shivani Khan, Janie Sheridan, Iain Smith, Catherine Woodstock Striley, David Taylor, and Adam R. Winstock<br/>17. Polysubstance use / Jason P. Connor and Gerald F. X. Feeney<br/>18. Injecting drug use / Robert Batey, Katherine M. Conigrave, Paul Haber, and John Strang<br/>19. Gambling / Henrietta Bowden-Jones, Sanju George, Yasunobu Komoto, David J. Nutt, <i>and Taku Sato</i><br/>20. Gaming / Hideki Nakayama and Hiroshi Sakuma<br/>21. Other addictive disorders / Takayuki Harada, Susumu Higuchi, Satoko Mihara, and John B. Saunders<br/>22. Psychiatric comorbidity / Glenys Dore, Anne Lingford-Hughes, and John B. Saunders<br/>23. Specific clinical situations / Noeline C. Latt, John B. Saunders, and Sue Wilson<br/>24. Special populations / Sawitri Assanangkornchai, Tatiana Balachova, Yvonne Bonomo, Katherine M. Conigrave, Ilana B. Crome, Glenys Dore, Bradley Freeburn, Marianne Jauncey, Michael Levy, Corinne Lim, Ross McCormick, and Kim Wolff<br/>25. Substance use and specific health care settings / Jonathan Brett, Tim Neumann, Richard Saitz, John B. Saunders, Claudia Spies, and Pierluigi Struzzo<br/>26. Legal and ethical issues / Katherine M. Conigrave, Glenys Dore, Emily Finch, Ralph Hingson, Noeline C. Latt, Sally Porter, and John B. Saunders.

::Summary## This book provides an accessible, up-to-date understanding of how to treat patients with substance and non-substance-related addiction. It covers all the typical substance and non-substance use disorders and presents evidence in a case-based format. Concise and comprehensive, opening chapters relay a preliminary assessment of addiction disorders and their neurobiology. Subsequent chapters then offer specific treatment options, challenges, and cases relating to the abuse of distinct substances. The substances mentioned earlier include alcohol, opioids, stimulants, hallucinogens, and sedatives. Additionally, one chapter covers the unique issues associated with treating behavioral addictions, such as sex and gambling. Each chapter will outline cases in a fashion that will optimize the reader's experience. In closing, the book examines co-occurring substance use disorders and mental illness. An invaluable addition to the Psychiatry Update Series, Addiction Medicine is an essential reference for mental health clinicians, as well as primary care and family medicine clinicians.<br/>::Contents##<br/>1. Assessment of Substance Use Disorders<br/>2. Neurobiology of Substance Use Disorders<br/>3. Alcohol Use Disorder<br/>4. Cannabis Use Disorder<br/>5. Hallucinogen-Related Disorders<br/>6. Inhalant Use Disorders<br/>7. Opioid Use Disorder: A Case-Based Approach<br/>8. Sedative, Hypnotic, or Anxiolytic-related Disorders<br/>9. Stimulant-Related Disorders<br/>10 . Nicotine Dependence and Tobacco Use Disorder Treatment<br/>11. Behavioral Addictions<br/>12. Co-Occurring Substance Use Disorders and Mental Illness.

::Summary## "Integrating scientific knowledge with today’s most effective treatment options, Addiction Medicine: Science and Practice, 2nd Edition, provides a wealth of information on addictions to substances and behavioral addictions. It discusses the concrete research on how the brain and body are affected by addictions, improving your understanding of how patients develop addictions and how best to personalize treatment and improve outcomes. This essential text is ideal for anyone who deals with patients with addictions in clinical practice, including psychiatrists, health psychologists, pharmacologists, social workers, drug counselors, trainees, and general physicians/family practitioners"--Publisher's description.<br/>::Contents##<br/>Emerging health perspectives<br/>The epidemiology of alcohol and drug disorders<br/>United States federal drug policy<br/>Historical perspectives of addiction<br/>Diagnosis and classification of substance use disorders<br/>Drug reinforcement in animals<br/>Role of human laboratory studies in the development of medications for alcohol and substance use disorders<br/>Conditioning of addiction<br/>Overlapping striatal circuits and molecular mechanisms in rodent models of addiction and depression<br/>The role of endocannabinoids in amphetamine-driven actions in dopamine neurons :implications for understanding and treating dysfunction in the mesolimbic circuit<br/>Pain and negative affect<br/>Genetic vulnerability to substance use disorders<br/>The assessment and treatment of addiction :best practices in a direct-to-consumer age<br/>Metabolomics in drug response and addiction<br/>Neuroimaging findings in substance use disorders<br/>Neurobiological basis of drug reward and reinforcement<br/>Neurobehavioral toxicology of substances of abuse<br/>Animal models of substance use disorders :motivational perspective<br/>Novel methodologies :proteomic approaches in substance abuse research<br/>Neuroinflammatory processes in drug addiction<br/>Alcohol :clinical aspects<br/>Cocaine<br/>Nicotine<br/>Cannabis :an overview of the empirical literature<br/>Opiates and prescription drugs<br/>Clinical aspects of methamphetamine<br/>Sedative-hypnotics and anxiolytics<br/>Clinical aspects of inhalant addiction<br/>Anabolic-androgenic steroids<br/>Caffeine<br/>Serotonergic hallucinogens<br/>Ketamine and phencyclidine<br/>The biology and treatment of gambling disorder<br/>Implications of food addiction for understanding and treating binge eating disorder<br/>Compulsive buying<br/>Sexual behavior as an addictive or compulsive phenomenon<br/>New era of internet addiction research in china<br/>Hoarding as a behavioral addiction<br/>Motivational interviewing :emerging theory, research, and practice<br/>Cognitive behavioral therapy for addiction<br/>Community reinforcement approach and contingency management therapies<br/>Relapse prevention and recycling in addiction<br/>Brief and e-health interventions for the treatment of alcohol or other drug addiction<br/>Self-help approaches for addictions<br/>Community clinics<br/>Unhealthy alcohol and other drug use in primary care<br/>Criminal justice system and addiction treatment<br/>Adolescent neurocognitive development and school-based drug abuse prevention and treatment<br/>The therapeutic community for drug abuse treatment :a journey yet unfolding in the recovery movement<br/>Substance use-focused mutual-help groups :processes and outcomes<br/>Pharmacotherapy for alcoholism and some related psychiatric and addictive disorders :scientific basis and clinical findings<br/>Alcohol withdrawal :treatment and application<br/>Pharmacotherapy of cocaine addiction<br/>Opioid overdose<br/>Methamphetamine<br/>Potential pharmacotherapies for cannabis dependence<br/>Hallucinogens<br/>Molecular genetics and the treatment of addiction<br/>Physical considerations for treatment complications of alcohol and drug use and misuse<br/>Quadruple diagnosis :substance use disorder, comorbid psychopathology, human immunodeficiency virus infection, and hepatitis c virus infection<br/>Substance use stigma as a barrier to treatment and recovery<br/>Religiousness, spirituality, and addiction :an evidence-based review<br/>In silico models of alcohol kinetics :a deterministic approach<br/>In silico models of alcohol dependence treatment :a stochastic approach<br/>Dynamic and systems-based models for evaluating hypotheses related to predicting treatment response<br/>Enhancing positive outcomes for children of substance-abusing parents<br/>Alcohol and substance abuse in African Americans<br/>Substance use disorders in health care professionals<br/>Identification and treatment of alcohol or drug dependence in the elderly<br/>Alcohol and drugs of abuse in pregnant women :effects on the fetus and newborn, mode of action, and maternal treatment<br/>Forensic issues<br/>Disability and addiction<br/>The homeless<br/>Opening new vistas in basic and preclinical addiction research<br/>National Institute on Drug Abuse (NIDA):medications to treat opioid use disorder<br/>TIP medications for opioid use disorder<br/>The ASAM National practice guideline for the use of medications in the treatment of addiction involving opioid use.

::Summary## "While there is a wealth of published information on addiction medicine, the psychological aspects of alcohol abuse, and behavioral medicine with regard to addiction, virtually none of the existing resources were written with the primary care provider in mind. Addressing Unhealthy Alcohol Use in Primary Care is a handy reference for primary care clinicians who are confronted by patients with these problems daily, and who wish to successfully address these issues in their practice. Focusing on the literature and science relevant to practicing providers, this book covers the range of interventions appropriate for this setting. Topics include assessment, brief counseling interventions, pharmacotherapy, referrals to both specialty care and Alcoholics Anonymous (and other self-help programs), psychiatric comorbidity and other drug use, and other information specific to the needs of the primary care clinician. The vast majority of people with health risks and consequences related to alcohol use receive little to no attention from healthcare, despite the fact that alcohol is a leading cause of early preventable death. This book is a guide to identifying and addressing unhealthy alcohol use in hopes of improving the lives of patients."--publisher's website<br/>::Contents##<br/>Unhealthy Alcohol Use: What is it? What Can and Should We be Doing About it in Primary Care Settings? / Richard Saitz<br/>Screening for Unhealthy Alcohol Use / Katharine Bradley MD, MPH, Douglas Berger<br/>Assessment of Unhealthy Alcohol Use in Primary Care / Hillary Kunins, Chinazo Cunningham<br/>Brief Intervention for Unhealthy Alcohol Use / Richard Saitz<br/> Alcohol Pharmacotherapies / Dylan Brock, Babak Tofighi<br/>Making Effective Referrals to Specialty Care / Darius A. Rastegar<br/>Making Effective Referrals to Alcoholics Anonymous and Other 12-step Programs / Maryann Amodeo, Luz Marilis López<br/>Management of Patients with Alcohol Dependence in Recovery: Options for Maintenance and Anticipating and Managing Relapse in Primary Care / Thomas J. Doyle, Peter D. Friedmann<br/>Managing Pain in the Context of Unhealthy Alcohol Use / Erik W. Gunderson, Daniel P. Alford<br/>Medical Consequences of Unhealthy Alcohol / Adam J. Gordon, Joanne M. Gordon<br/>Psychiatric Comorbidity / Amy Harrington<br/>Other Drug Use / Jennifer McNeely MD, MS<br/>To Drink or Not to Drink? "Moderate" Alcohol Consumption in a Clinical Context / Timothy S. Naimi<br/>Electronic and Other Self-Help Materials for Unhealthy Alcohol Use in Primary Care / Steven J. Ondersma PhD<br/>Screening and Brief Intervention Practice Systems and Implementation / John Muench MD, MPH<br/>Confidentiality / Richard Saitz<br/>Choices for Patients and Clinicians: Ethics and Legal Issues / Michael Weaver<br/>Hospital Management / Richard D. Blondell<br/>Perioperative Management / Daniel P. Alford<br/>Physicians with Unhealthy Alcohol Use / Luis T. Sanchez.

::Summary## This book offers up-to-date and comprehensive coverage of the diagnosis and therapy of adenocarcinoma of the esophagogastric junction (EGJ). As is appropriate in the era of multidisciplinary and multimodal treatment, the contributions of all the various specialists involved cooperatively in the treatment of EGJ cancer are thoroughly described. Detailed attention is also paid to the significance of preneoplastic lesions, such as Barrett esophagus. The final part of the book represents a surgical atlas documenting the techniques used in the EGJ region, with superb color images and stepwise description of procedures. Against the background of the rapidly increasing incidence in EGJ cancer, especially evident in Western countries, there is a need for greater uniformity in management strategies, which currently vary significantly across the world. This book provides appropriate guidance that will assist all practitioners involved in the diagnosis and treatment of EGJ cancers, including surgeons, oncologists, and radiotherapists.<br/>::Contents##<br/>Foreword<br/>Preface<br/>1 Epidemiology and risk factors<br/>2 Barrett's esophagus: pathogenesis and prevention<br/>3 Surveillance in Barrett's esophagus and Dysplasia<br/>4 Ablation techniques for Barrett's esophagus and Dysplasia<br/>5 Endoscopic resection for Barrett's esophagus and Dysplasia<br/>6 7th Edition AJCC/UICC Staging: Esophagus and Esophagogastric Junction<br/>7 Siewert Classification of Adenocarcinoma of the Esophagogastric Junction: still in or already out?<br/>8 Preoperative work- up: conventional radiology, ultrasonography, CT scan and MRI<br/>9 Role of PET/CT and MRI in the prediction of response to neoadjuvant treatment<br/>10 Molecular biology in the prediction of response to neoadjuvant treatment<br/>11 Pathological response to neoadjuvant treatment: more questions than answers<br/>12 Hospital volume and centralization in EGJ cancer<br/>13 Patient selection and tailored treatment principles<br/>14 How to treat EGJ cancer: indications and treatment strategy<br/>15 Chemotherapy in EGJ cancer<br/>16 Chemoradiation in EGJ cancer<br/>17 Signet ring carcinoma in EGJ: what is it?<br/>18 Morbi- mortality and treatment of complications<br/>19 Long term results in surgery alone and multimodal treatments<br/>20 Open or minimally invasive? Comparison of early and late results<br/>21 Enhanced Recovery After Surgery (ERAS and nutritional aspects<br/>22 Unresectable and metastatic cancer<br/>23 Recurrence: treatment or just palliation?<br/>24 Follow- up and quality of life<br/>25 Surgical anatomy of esophagus and esophagogastric junction<br/>26 Surgical technique: open procedures<br/>27 Surgical technique: minimally invasive procedures<br/>Subject Index.

::Summary## This book aims to provide updated facts and treatments for practicing gynecologists and postgraduate doctors to enhance their understanding of pathogenesis, pathology, symptoms and diagnostic imaging technology of adenomyosis, such as to select appropriate treatments, to improve the symptoms, fertility and the quality of life of women with adenomyosis. This book also particularly introduces the new treatment for adenomyosis using the non-invasive High Intensity Focused Ultrasound ablation treatment. Hopefully, it will provide a better understanding of its operation, effectiveness, and pregnancy outcome, to formulate a more successful treatment strategy for this disease.<br/>::Contents##<br/>The Incidence and Clinical Impact of Adenomyosis<br/>The Pathogenesis of Adenomyosis<br/>The Pathology of Adenomyosis<br/>The Clinical Features and Diagnosis of Adenomyosis<br/>Adenomyosis and Pain<br/>Adenomyosis and Abnormal Uterine Bleeding<br/>Adenomyosis and Infertility<br/>Ultrasound Manifestation and Classification of Adenomyosis<br/>MRI Manifestation and Classification of Adenomyosis<br/>The Medical Treatment of Adenomyosis<br/>The Surgical Treatment for Adenomyosis<br/>Uterine Artery Embolization Treatment for Adenomyosis<br/>Principles and Protocols of HIFU Ablation<br/>HIFU Ablation<br/>The Therapeutic Result of HIFU Ablation for Adenomyosis<br/>Adjuvant Therapy of HIFU Ablation for Adenomyosis.-Pregnancy Outcomes after Myomectomy and HIFU Treatment<br/>Conclusion.

::Contents##<br/>Adenosine and Metabolism--A Brief Historical Note / Bertil B. Fredholm<br/>Adenosine Metabolism, Adenosine Kinase, and Evolution / Jaoek Park and Radhey S. Gupta<br/>Adenosine and Energy Metabolism--Relationship to Brain Bioenergetics / Xuesong Chen, Liang Hui and Jonathan D. Geiger<br/>Adenosine and Autocrine Metabolic Regulation of Neuronal Activity / Masahito Kawamura Jr. and David N. Ruskin<br/>Physiologic and Metabolic Regulation of Adenosine: Mechanisms / Chris G. Dulla and Susan A. Masino<br/>The Double-Edged Sword: Gaining Adenosine at the Expense of ATP. How to Balance the Books / Stephanie zur Nedden, Alexander S. Doney and Bruno G. Frenguelli<br/>Downstream Pathways of Adenosine / Ana M. Sebastião, Sofia Cristóvão-Ferreira and Joaquim A. Ribeiro<br/>Astrocytic ATP Release / Dustin J. Hines and Philip G. Haydon<br/>Role of Striatal A2A Receptor Subpopulations in Neurological Disorders / Sergi Ferré, César Quiroz, Marco Orrú, Xavier Guitart and Seema Gulyani, et al.<br/>Sleep and Adenosine: Human Studies / Tarja Porkka-Heiskanen<br/>Adenosine and Other Purinergic Products in Circadian Timing / Christine Muheim and Steven A. Brown<br/>Adenosine in the Immune System / György Hask, Balázs Koscsó́ and Balázs Csóka<br/>The Bioenergetic Network of Adenosine in Hibernation, Sleep, and Thermoregulation / Kelly L. Drew and Tulasi R. Jinka<br/>Adenosine and Stroke / Felicita Pedata, Anna Maria Pugliese, Francesca Corti and Alessia Melani<br/>The Many Roles of Adenosine in Traumatic Brain Injury / Patrick M. Kochanek, Jonathan D. Verrier, Amy K. Wagner and Edwin K. Jackson<br/>Therapeutic Perspectives of Adenosine Receptor Compounds in Functional Restitution After Spinal Cord Injury / Kwaku D. Nantwi<br/>Adenosine and Pain / Jana Sawynok<br/>Symptomatic and Neuroprotective Effects of A2A Receptor Antagonists in Parkinson's Disease / Annalisa Pinna, Nicola Simola, Lucia Frau and Micaela Morelli<br/>Adenosine Receptors and Alzheimer's Disease / David Blum, Ursula Sandau, Cyril Laurent, Vânia Batalha and Antoine Leboucher, et al.<br/>Adenosine Receptors in Huntington's Disease / David Blum, Alberto Martire, Sylvie Burnouf, Bernard Sablonnière and Pierre Krystkowiak, et al.<br/>Adenosine and Multiple Sclerosis / Maria Victoria Sánchez-Gómez, Estibaliz González-Fernández, Rogelio O. Arellano and Carlos Matute<br/>Adenosinergic Perspectives on Schizophrenia: Opportunity for an Integrative Synthesis / Benjamin K. Yee, Philipp Singer and Detlev Boison<br/>The Role of Adenosine in the Ventral Striatal Circuits Regulating Behavioral Activation and Effort-Related Decision Making: Importance for Normal and Pathological Aspects of Motivation / John D. Salamone, Merce Correa, Patrick A. Randall, Eric J. Nunes and Marta Pardo, et al.<br/>Adenosine and Autism: Physiological Symptoms and Metabolic Opportunities / Julia Svedova, Inge-Marie Eigsti and Susan A. Masino<br/>Stress, Brain Adenosine Signaling, and Fatigue-Related Behavioral Processes / Traci N. Plumb, Sarah R. Sterlace, Kelly A. Cavanaugh and Thomas R. Minor<br/>Disruption of Adenosine Homeostasis in Epilepsy and Therapeutic Adenosine Augmentation / Detlev Boison<br/>Ketogenic Diet and Epilepsy: The Role of Adenosine / Jong M. Rho, Beth Zupec-Kania and Susan A. Masino<br/>Silk: A Biocompatible and Biodegradable Biopolymer for Therapeutic Adenosine Delivery / Eleanor M. Pritchard, Detlev Boison and David L. Kaplan<br/>Anatomical Distribution of Nucleoside System in the Human Brain and Implications for Therapy / Zsolt Kovács and Arpád Dobolyi.

::Contents##<br/>Adenosine receptor biology in the central nervous system / Michael Freissmuth and Karl-Norbert Klotz<br/>Adenosine signaling throughout development / Stefania Zappettini and Christophe Bernard<br/>Influence of adenosine on synaptic excitability / Detlev Boison, Raquel B. Dias, Traci Plumb, Sofia Cristóvão-Ferreira and Ana M. Sebastião<br/>Regulation of synaptic transmission by adenosine at the neuromuscular junction / Paula Pousinha and Joaquim A. Ribeiro<br/>Gene regulation of adenosine A₂a receptors in the central nervous system<br/>Sleep, adenosine, and neurodegeneration / Theresa E. Bjorness and Robert W. Greene<br/>National vs glial cell contribution to adenosine A₂a receptor-induced neurodegeneration / Antonella Ferrante, Maria T. Tebano, Alberto Martire, Maria R. Domenici and Patrizia Popoli<br/>Adenosine and oxygen/glucose deprivation in the brain / Felicita Pedata, Ilaria Dettori, Irene Fusco, Elisabetta Coppi, Anna M. Pugliese and Alessia Melani<br/>Adenosine receptors and memory disorders / Alexandre De Mendonca, David Blum and Jonathan D. Geiger<br/>Control of motor function by adenosine A₂a receptors in Parkinson's and Huntington's disease / Annalisa Pinna, Jadwiga Wardas, Maria R. Domenici, Patrizia Popoli, Giovanni Cossu and Micaela Morelli<br/>Adenosine receptors oligomers in Parkinson's disease / Víctor Fernández-Dueñas and Francisco Ciruela<br/>Adenosine control of striatal function / Sergi Ferré.

::Summary## Adenovirus infection: Global Status is one in a series of GIDEON ebooks which explore all individual infectious diseases, drugs, vaccines, outbreaks, surveys and pathogens in every country of the world. Data are based on the GIDEON web application (www.gideononline.com) which relies on standard text books, peer-review journals, Health Ministry reports and ProMED, supplemented by an ongoing exhaustive search of the medical literature. The ebook includes: 1. Descriptive epidemiology 2. Clinical features 3. Distribution map 4. Images 5. Global status and status in every relevant country 6. References.<br/>::Contents##<br/>ADENOVIRUS INFECTION: GLOBAL STATUS<br/>Copyright<br/>Introduction: The GIDEON e-book series<br/>Table of Contents<br/>Adenovirus infection<br/>Epidemiology<br/>Agent<br/>Reservoir<br/>Vector<br/>Vehicle<br/>Incubation Period<br/>Diagnostic Tests<br/>Typical Adult Therapy<br/>Typical Pediatric Therapy<br/>Vaccine<br/>Clinical Hints<br/>Synonyms<br/>Clinical<br/>References<br/>Distribution Map<br/>Images<br/>Afghanistan<br/>References<br/>Albania<br/>References<br/>Algeria<br/>References<br/>Angola<br/>References<br/>Argentina<br/>References<br/>Armenia<br/>References<br/>Australia<br/>References<br/>Austria<br/>References<br/>Azerbaijan<br/>Bahrain<br/>References<br/>Bangladesh<br/>References<br/>Belarus<br/>References<br/>Belgium<br/>References<br/>Brazil<br/>References<br/>Bulgaria<br/>References<br/>Burkina Faso<br/>References<br/>Cambodia<br/>References<br/>Cameroon<br/>References<br/>Canada<br/>References<br/>Central African Republic<br/>References<br/>Chad<br/>References<br/>Chile<br/>References<br/>China<br/>References<br/>Colombia<br/>References<br/>Congo<br/>References<br/>Croatia<br/>References<br/>Cuba<br/>References<br/>Cyprus<br/>References<br/>Denmark<br/>References<br/>Djibouti<br/>References<br/>Egypt<br/>References<br/>El Salvador<br/>References<br/>Estonia<br/>Finland<br/>References<br/>France<br/>References<br/>Gabon<br/>References<br/>Georgia<br/>References<br/>Germany<br/>References<br/>Ghana<br/>References<br/>Greece<br/>References<br/>Guadeloupe<br/>References<br/>Guam<br/>References<br/>Honduras<br/>References<br/>Hong Kong<br/>References<br/>Hungary<br/>References<br/>India<br/>References<br/>Indonesia<br/>References<br/>Iran<br/>References<br/>Ireland and Northern Ireland<br/>References<br/>Israel<br/>References<br/>Italy<br/>References<br/>Ivory Coast<br/>References<br/>Jamaica<br/>References<br/>Japan<br/>References<br/>Jordan<br/>References<br/>Kenya<br/>References<br/>Kuwait<br/>References<br/>Laos<br/>References<br/>Lebanon<br/>References<br/>Libya<br/>References<br/>Madagascar<br/>References<br/>Malawi<br/>References<br/>Malaysia<br/>References<br/>Mexico<br/>References<br/>Moldova<br/>Morocco<br/>References<br/>Mozambique<br/>References<br/>Myanmar<br/>References<br/>Nepal<br/>References<br/>New Caledonia<br/>References<br/>New Zealand<br/>References<br/>Nicaragua<br/>References<br/>Nigeria<br/>References<br/>Norway<br/>References<br/>Oman<br/>References<br/>Pakistan<br/>References<br/>Papua New Guinea<br/>References<br/>Peru<br/>References<br/>Poland<br/>References<br/>Portugal<br/>References<br/>Qatar<br/>References<br/>Romania<br/>References<br/>Rwanda<br/>References<br/>Saudi Arabia<br/>References<br/>Scotland<br/>References<br/>Senegal<br/>References<br/>Serbia and Montenegro<br/>References<br/>Singapore<br/>References<br/>Slovakia<br/>References<br/>South Africa<br/>References<br/>South Korea<br/>References<br/>Spain<br/>References<br/>Sudan and South Sudan<br/>References<br/>Sweden<br/>References<br/>Switzerland<br/>References<br/>Taiwan<br/>References<br/>Tanzania<br/>References<br/>Thailand<br/>References<br/>The Canary Islands<br/>References<br/>The Czech Republic<br/>References<br/>The Democratic Republic of Congo<br/>References<br/>The Netherlands<br/>References<br/>The Philippines<br/>References<br/>The Russian Federation<br/>References<br/>The U.S. Virgin Islands<br/>References<br/>The United Kingdom<br/>References<br/>The United States<br/>References<br/>The World<br/>References<br/>Trinidad and Tobago<br/>References<br/>Tunisia<br/>References<br/>Turkey<br/>References<br/>Uganda<br/>References<br/>Ukraine<br/>Venezuela<br/>References<br/>Vietnam<br/>References<br/>Zambia<br/>References<br/>Adenovirus vaccine<br/>Mechanism of Action<br/>Typical Adult Dosage<br/>Typical Pediatric Dosage<br/>Subsequent booster<br/>Toxic Effects for Adenovirus vaccine (0 listed)<br/>Contraindications for Adenovirus vaccine (5 listed)<br/>Trade names of Adenovirus vaccine (0 listed)<br/>About GIDEON

::Summary## Parents will find the latest recommendations for the treatment and care of children with ADHD in the fully revised and updated edition of this award-winning guide.<br/>::Contents##<br/>Please note<br/>A note on gender<br/>Introduction<br/>Chapter 1. What is ADHD?<br/>Chapter 2. Does my child have ADHD? Evaluation and diagnosis<br/>Chapter 3. What should we do? Treatment options<br/>Chapter 4. The role of medications<br/>Chapter 5. Managing ADHD at home<br/>Chapter 6. Parent training in behavior management: parenting techniques that work<br/>Chapter 7. Your child at school<br/>Chapter 8. Advocating for your child and others<br/>Chapter 9. When is it not just ADHD: identifying coexisting conditions<br/>Chapter 10. Complementary and alternative treatments for ADHD<br/>Chapter 11. ADHD in adolescence<br/>Chapter 12. A look at your child's future<br/>Index.

::Contents##<br/>Neuroscience, Neuropsychology, and Attention-Deficit Hyperactivity Disorder: ADHD as a Model of Brain-Behavior Relationships<br/>ADHD, Attention, and DSM Diagnosis: History and Context<br/>ADHD and Neuropsychological Nomenclature<br/>Diagnostic Systems and Etiological Models<br/>Neuropsychological Models of Attention and ADHD<br/>Broad-Based Neuropsychological Test Batteries and ADHD<br/>Preliminary Answers to the Question<br/>Dimensional Approaches for Evaluating Disorders: Research Domain Criteria<br/>The Neocortex, Regional Functional Specialization, and Cognitive Networks<br/>Large-Scale Brain Networks and Functional Connectivity<br/>The Ontogeny of Functional Brain Networks<br/>Large-Scale Brain Network Disturbances in ADHD<br/>The Selection Problem<br/>The Basal Ganglia<br/>The Basal Ganglia and Intention Programs<br/>The Basal Ganglia: Focused Attention and Learning Through Integrative Networks<br/>Reward Circuitry and the Basal Ganglia<br/>The Cerebellum<br/>The Modular Organization of the Cerebellum<br/>The Development of Motor Skills, Executive Functions, and a Relationship to ADHD: A Preliminary Review<br/>Revisiting Neuropsychological Testing and the Paradox of ADHD<br/>Neural Network Dynamics: How Large-Scale Brain Networks Interact<br/>Concluding Remarks.

::Summary## ADHD in Adults: A Practical Guide to Evaluation and Management is the product of a unique collaboration of international specialists. This volume offers easy-to-read guidance, and includes checklists, rating scales and treatment planning tools. It was designed for a broad audience of caregivers working in diverse settings, including psychiatrists, social workers, primary care physicians, nurse specialists and psychologists. The authors are highly acclaimed clinicians, investigators and educators. They offer step-by-step guidance for implementation of best practices, drawing from clinical research and their experience treating thousands of patients. They cover diagnosis, treatment planning, and state-of-the-art application of pharmacology, psychotherapy, skill-building, family system and environmental interventions - for both simple and complex cases. The scales and worksheets in this Guide were developed to efficiently facilitate assessment and management. The Editor is an international leader in the field from the Clinical and Research Program in Adult ADHD at Massachusetts General Hospital (MGH) and Harvard Medical School, which has made pioneering and highly cited contributions to the understanding of ADHD. This Guide is a definitive, indispensable resource for all health providers who wish to optimize their approach to adult patients with ADHD.<br/>::Contents##<br/>1. ADHD in Adults: A Clinical Concern / Philip Asherson<br/>2. Clinical Assessment of ADHD in Adults / Craig B.H. Surman<br/>3. Treatment Planning for Adults with ADHD / Craig B.H. Surman<br/>4. Neuropsychological Assessment of ADHD and Executive Function Deficits in Adults / Daniela de Bustamante Carim and Helenice Charchat Fichman<br/>5. Stimulant Pharmacotherapy for Adults with ADHD / Paul Hammerness<br/>6. Non-stimulant Drug Treatments for Adults with ADHD / David Coghill<br/>7. Psychosocial Treatment for Adult ADHD / Laura E. Knouse and Steven A. Safren<br/>8. Managing ADHD in Adults with Common Comorbidities / Esther Sobanski, Georgios Paslakis, Michael Schredl, Stephanie Daffner, and Barbara Alm<br/>9. Managing ADHD in Adolescence and Young Adulthood: Emerging Comorbidities and Tailored Treatment / Inmaculada Escamilla<br/>10. ADHD in Families / Thomas Jans and Christian Jacob<br/>11. Clinical Dilemmas in the Assessment and Management of ADHD in Adults: A Psychiatrist's View from an Urban Hospital Clinic / Anton Pesok.

::Summary## "Attention-deficit/hyperactivity sisorder (ADHD) is one of the most common behavior disorders of childhood. Mental health and school practitioners are frequently faced with the challenge of assessing children and adolescents who might have ADHD. The ADHD Rating Scale-5 is widely used by medical, mental health, and educational practitioners for a variety of activities including screening, diagnostic assessment, and evaluation of treatment outcome"--Provided by publisher.<br/>::Contents##<br/>Introduction to the ADHD rating scales<br/>Factor analysis<br/>Standardization and normative data<br/>Reliability and validity<br/>Interpretation and use of the scales for diagnostic and screening purposes<br/>Interpretation and use of the scales of evaluating treatment outcomes.

::Contents##<br/>Part I. What is known about adherence behavior<br/>1. Impact of Non-Adherence in Dermatology<br/>2. Models of Adherence<br/>3. Impact of demographic and treatment-related factors<br/>4. Non-attendance, predictors and interventions<br/>Part II. Methods of measuring adherence<br/>5. Using Retrospective Databases to Study Adherence<br/>6. Measuring Adherence in Clinical Trials<br/>7. How providers can assess their patients' adherence in clinical settings<br/>Part III. Adherence in specific diseases<br/>8. Topical application and variability of the de facto applied dose: technical aspects<br/>9. Adherence in Acne<br/>10. Psoriasis and adherence to therapy: individual, treatment-related and general factors<br/>11. Adherence in atopic dermatitis<br/>12. Adherence in Other Dermatologic Conditions<br/>Part IV. Strategies to improve adherence<br/>13. Optimizing the Physician-Patient Relationship and Educating the Patient about Adherence<br/>14. Choosing the treatment the patient is most likely to use<br/>15. Dealing with forgetfulness<br/>16. Building Motivation and Self-Efficacy.

::Summary## Poor adherence to therapy is one of the main obstacles to treatment effectiveness in schizophrenia. It is the main determinant of relapse, hospitalization, symptom persistence, and poor psychosocial functioning and outcome. Adherence to treatment is affected by various factors related to the disease characteristics, to the patient him- or herself, to the treatment, and to the therapeutic relationship. Some of these factors are modifiable, and both pharmacological and non-pharmacological strategies have been developed for this purpose.This book addresses the different aspects of adherence to treatment in schizophrenia and related disorders in a systematic but easy-to-use manual format. Chapters focus on a full range of issues, including pharmacological and non-pharmacological strategies to enhance adherence and continuity of care, relevant psychological factors, the importance of the patient-doctor relationship, and the need for an alliance with other care-givers. Adherence to Antipsychotics in Schizophrenia will be an invaluable asset for all who are involved in the care of patients with schizophrenia.<br/>::Contents##<br/>Poor adherence to antipsychotic medication in people with schizophrenia: diffusion, consequences, and contributing factors<br/> Pharmacological strategies to enhance adherence in schizophrenia<br/>Non-pharmacological strategies to enhance adherence and continuity of care in schizophrenia<br/>Psychological issues in improving adherence and alliance.

::Summary## The book documents the history of the prevention-of-mother-to child transmission of HIV (PMTCT) program in Guyana, as well as the impact of HIV on pregnant and postpartum women's adherence to antiretroviral therapy (ART). The book shows research work by reviewing the literature to investigate relevant adherence studies, presenting in-depth interviews on adherence perspectives of clinic patients and healthcare providers, and a cross-sectional descriptive study of pregnant women that investigated general adherence to pregnancy-related behaviours and ART, and the efficacy of a theoretical model (Health Belief Model) to understand and predict ART adherence within this group. Author discusses the factors affecting ART adherence among pregnant and postpartum women, since existing studies may not account for cultural and other local variations. The findings provide insight into the local situation, and will also inform policy and practice in Guyana, and the wider Caribbean Community (CARICOM).<br/>::Contents##<br/>Chapter 1: Introduction<br/>Chapter 2: HIV and AIDS in Guyana<br/>Chapter 3: Factors affecting antiretroviral therapy adherence among HIV-positive pregnant and postpartum women: an adapted systematic review<br/>Chapter 4: Characteristics of pregnant women in Guyana with and without HIV<br/>Chapter 5: Antiretroviral perspectives of pregnant and postpartum women in Guyana: barriers and facilitators<br/>Chapter 6: Adherence patterns to prenatal vitamins and pregnancy health behaviors<br/>Chapter 7: Predictors of ART adherence<br/>Chapter 8: Predicting adherence to antiretroviral therapy among pregnant women in Guyana: utility of the health belief model<br/>Chapter 9: Discussion and Key Implications.

::Contents##<br/>Introduction: history of the adhesion GPCR field / J̲örg Hamann, Alexander G. Petrenko<br/>Molecular and pharmacological properties of adhesion GPCRs. Classification, nomenclature, and structural aspects of adhesion GPCRs / Arunkumar Krishnan, Saskia Nijmeijer, Chris de Graaf, Helgi B. Schi̲th<br/>7TM domain structure of adhesion GPCRs / Chris de Graaf, Saskia Nijmeijer, Steffen Wolf, Oliver P. Ernst<br/>Understanding the structural basis of adhesion GPCR functions / Demet Araç, Norbert Sträter, Elena Seiradake<br/>Control of adhesion GPCR function through proteolytic processing / Matthias Nieberler, Robert J. Kittel, Alexander G. Petrenko, Hsi-Hsien Lin [and others]<br/>Tethered agonism: a common activation mechanism of adhesion GPCRs / Ines Liebscher, Torsten Sch̲öneberg<br/>Versatile signaling activity of adhesion GPCRs / Ayush Kishore, Randy A. Hall<br/>Adhesion GPCR-related protein networks / Barbara Knapp, Uwe Wolfrum<br/>The relevance of genomic signatures at adhesion GPCR loci in humans / Peter Kovacs, Torsten Sch̲öneberg<br/>Adhesion GPCRs as pharmakotargets in organ function and development. Adhesion GPCRs as a putative class of metabotropic mechanosensors / Nicole Scholz, Kelly R. Monk, Robert J. Kittel, Tobias Langenhan<br/>Adhesion GPCRs govern polarity of epithelia and cell migration / David Strutt, Ralf Schnabel, Franziska Fiedler, Simone Pr̲mel<br/>Adhesion GPCRs as novel actors in neural and glial cell functions: from synaptogenesis to myelination / Séverine M. Sigoillot, Kelly R. Monk, Xianhua Piao, Fekrije Selimi, Breanne L. Harty<br/>Control of skeletal muscle cell growth and size through adhesion GPCRs / James P. White<br/>Adhesion GPCR function in pulmonary development and disease / Marie-Gabrielle Ludwig, Klaus Seuwen, James P. Bridges<br/>Adhesion GPCRs as modulators of immune cell function / J̲örg Hamann, Cheng-Chih Hsiao, Chang Sup Lee, Kodi S. Ravichandran, Hsi-Hsien Lin<br/>Heart development, angiogenesis, and blood-brain barrier function is modulated by adhesion GPCRs / Gentian Musa, Felix B. Engel, Colin Niaudet<br/>Adhesion GPCRs in tumorigenesis / Gabriela Aust, Dan Zhu, Erwin G. Van Meir, Lei Xu.

::Summary## This book focuses on the subsets of soft tissue tumors that show adipocytic, vascular or skeletal muscle differentiation. It reviews the surgical pathologists approach to diagnosing soft tissue tumors guided by vital morphological and immunohistochemical data in the differential diagnosis of this family of tumors. Written by experts in the field, the text contains a concise yet comprehensive summary of the current status of the field that helps guide diagnosis and patient management, and stimulates investigative efforts. The book is filled with high-quality drawings of the salient histologic features of these various tumors, alongside photomicrographs and tips and tricks that help the relatively untrained or inexperienced eye to recognize the various structures or cell types that comprise each of these lesions. This innovative approach seeks to make recognition of these tumors easier. Adipocytic, Vascular and Skeletal Muscle Tumors serves as a valuable resource for pathologists, oncologists, surgeons, and researchers dealing with and interested in these complex and challenging tumors.<br/>::Contents##<br/>Intro<br/>Foreword<br/>Contents<br/>Contributors<br/>Introduction<br/>1: Adipocytic Tumors<br/>Introduction<br/>Lipoma (Fig. 1.2)<br/>Lipomatosis of Nerve (Fig. 1.7)<br/>Angiolipoma (Fig. 1.10)<br/>Spindle Cell/Pleomorphic Lipoma (Fig. 1.13)<br/>Hemosiderotic Fibrolipomatous Tumor (HFLT) (Fig. 1.18)<br/>Lipoblastoma (Fig. 1.20)<br/>Angiomyolipoma (AML)<br/>Myelolipoma (Fig. 1.23)<br/>Hibernoma (Fig. 1.25)<br/>Chondroid Lipoma (Fig. 1.27)<br/>Liposarcoma<br/>ALT/WDLPS<br/>Dedifferentiated Liposarcoma (DDLPS)<br/>Myxoid/High-Grade Myxoid (Round Cell) Liposarcoma<br/>Pleomorphic Liposarcoma (PLPS) (Fig. 1.57) Tricks for a Better Diagnosis of Adipocytic Tumors<br/>Essential Bibliography<br/>2: Vascular Tumors<br/>Introduction<br/>Malformative Vascular Lesions<br/>Classical Vasoformative Tumors<br/>Capillary (Lobular) Hemangioma (Fig. 2.1)<br/>Congenital Hemangioma<br/>Infantile/Juvenile Hemangioma (Fig. 2.6)<br/>Cherry (Senile) Hemangioma (Fig. 2.8)<br/>Microvenular Hemangioma (Fig. 2.10)<br/>Cavernous Hemangioma (Fig. 2.13)<br/>Arteriovenous Hemangioma (Fig. 2.17)<br/>Intramuscular Hemangioma (Fig. 2.19)<br/>Angiomatosis<br/>Lymphangioma<br/>Lymphangioma Circumscriptum<br/>Cavernous Lymphangioma Benign Lymphangioendothelioma<br/>Lymphangiomatosis<br/>Littoral Cell Angioma (LCA)<br/>Angiosarcoma (Fig. 2.24)<br/>Reactive Vascular Lesions<br/>Papillary Endothelial Hyperplasia (PEH) (Fig. 2.26)<br/>Bacillary Angiomatosis (Fig. 2.28)<br/>Reactive Angioendotheliomatosis (Fig. 2.30)<br/>Glomeruloid Hemangioma (GH) (Fig. 2.32)<br/>Vascular Tumors with Hobnail Endothelium<br/>Hobnail Hemangioma (HH)<br/>Papillary Intralymphatic Angioendothelioma (PILA) (Dabska Tumor) (Fig. 2.35)<br/>Acquired Elastotic Hemangioma (Fig. 2.37)<br/>Retiform Hemangioendothelioma (RH) (Fig. 2.39) Composite Hemangioendothelioma (CH)<br/>Post-irradiation Atypical Vascular Lesions (AVL) (Fig. 2.41)<br/>Vascular Tumors with Spindle Cell Phenotype<br/>Spindle Cell Hemangioma (SCH) (Fig. 2.44)<br/>Kaposi Sarcoma (KS) (Fig. 2.46)<br/>Kaposiform Hemangioendothelioma (Fig. 2.51)<br/>Spindle Cell Angiosarcoma<br/>Vascular Tumors with Epithelioid Phenotype<br/>Epithelioid Hemangioma (EH)<br/>Epithelioid Angiomatous Nodule (EAN) (Fig. 2.55)<br/>Pseudomyogenic Hemangioendothelioma (PHE) (Fig. 2.57)<br/>Epithelioid Hemangioendothelioma (EHE) (Fig. 2.59)<br/>Epithelioid Angiosarcoma (EAS) (Fig. 2.61) Tricks for a Correct Diagnosis of Vascular Tumors<br/>Essential Bibliography<br/>3: Skeletal Muscle Tumors<br/>Introduction<br/>Rhabdomyoma<br/>Adult-Type Rhabdomyoma (Fig. 3.1)<br/>Fetal (Juvenile) Rhabdomyoma (Fig. 3.3)<br/>Genital Rhabdomyoma (Fig. 3.5)<br/>Embryonal Rhabdomyosarcoma (Fig. 3.7)<br/>Alveolar Rhabdomyosarcoma (Fig. 3.9)<br/>Pleomorphic Rhabdomyosarcoma (Fig. 3.11)<br/>Spindle Cell/Sclerosing Rhabdomyosarcoma (Fig. 3.13)<br/>Malignant Ectomesenchymoma (MEM)<br/>Potential New Entities<br/>Tricks for a Correct Diagnosis of Skeletal Muscle Tumors<br/>Essential References<br/>Index

::Summary## Adipocytokines provide the circuitry by which adipose tissue communicates among its component cells which include adipocytes, stromal cells, immune cells and vascular elements, with adipose tissue depots in other locations throughout the body and with other tissues in order to regulate physiologic processes of energy intake, utilization, and distribution. Since disturbances, both qualitative and quantitative, in adipocytokine function contribute significantly to many of the comorbidities associated with obesity, including diabetes, cardiovascular disease and cancer, this volume, which discusses most of the major adipocytokines independently and collectively and their roles in normal and pathologic processes, should be useful to all individuals seeking a deeper understanding of these processes. Moreover, it provides a valuable complement to the series on Energy Balance and Cancer, in which each volume is focused on a specific aspect of this process, which now constitutes an expanding problem as the obesity pandemic continues and more of the population reaches the age where cancer is most prevalent. This volume should provide a valuable resource to all clinicians and scientists engaged in caring for susceptible patients and in exploring the relation between energy balance and cancer as well as an important platform to providing the background for research development.<br/>::Contents##<br/>Preface<br/>1. Adipocytes, Adipocytokines, and Cancer<br/>2. Adiponectin, Obesity, and Cancer<br/>3. Leptin in Cancer; Epidemiology and Mechanisms<br/>4. Leptin Signaling Pathways as Therapeutic Targets in Cancer<br/>5. Retinol Binding Protein 4: Role in Diabetes and Cancer<br/>6. Visfatin, Obesity, and Cancer<br/>7. Apelin and Cancer<br/>8. Novel Adipocytokines: Monocyte Chemotactic Protein-1, Plasminogen Activator Inhibitor-1, Chemerin<br/>9. Resistin, Obesity, and Cancer<br/>10. CRP Role in Cancer<br/>11. GI Peptides, Energy Balance and Cancer<br/>Index.

::Summary## The field of adipose tissue biology has been expanding at a very rapid pace in the last few years. Numerous advances have been made since publication of the first edition of this book, in terms of basic adipocyte biology, understanding of the determinants of obesity, distribution of body fat and weight loss, as well as the mechanisms linking excess adiposity to various co-morbidities. Adipose Tissue and Adipokines in Health and Disease, Second Edition contains updated chapters from the previous volume but as the field has evolved, some areas covered in the first edition have been refocused to address the new knowledge. The volume is divided in four sections: the first two deal with basic adipose tissue and adipokine biology, while the last two address the problem of obesity and alterations in adipose tissue function from an epidemiological and clinical standpoint. The chapters are written by experts in their fields and include the most up to date scientific information. Adipose Tissue and Adipokines in Health and Disease, Second Edition is a useful resource for physicians interested in adipose tissue biology and basic scientists who want to know more about applied aspects of the field. The book targets endocrinologists, residents and fellows, internists, nutritionists and general practitioners who are exposed to an ever-expanding obese population.

::Contents##<br/>Preface: Obesity, Adipose Tissue and Cancer Progression<br/>Metabolic Perturbations Associated with Adipose Tissue Dysfunction and the Obesity-Cancer Link<br/>Increased Adiposity and Colorectal Cancer<br/>Adiposity and Diabetes in Breast and Prostate Cancer<br/>Increased Adipocity and Endometrial Cancer Risk<br/>Adipokines: Soluble Factors from Adipose Tissue Implicated in Cancer<br/>Animal Models to Study the Interplay between Cancer and Obesity<br/>Unraveling the local influence of tumor-surrounding adipose tissue on tumor progression: cellular and molecular actors involved<br/>Trafficking of Cells from Adipose Tissue to Tumor Microenvironment<br/>The Impact of Obesity Intervention on Cancer: Clinical Perspectives<br/>Index.

::Summary## Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook. As an introduction oriented to pharmacy students, it is also written for scientist from different fields outside of pharmaceutics. (e.g. material scientist, material engineers, medicinal chemists) who might be working in a positions in pharmaceutical companies or whose work might benefit from basic training in the ADME concepts and some biological background. Pedagogical features such as objectives, keywords, discussion questions, summaries and case studies add valuable teaching tools. This book will provide not only general knowledge on ADME processes but also an updated insight on some hot topics such as drug transporters, multi-drug resistance related to pharmacokinetic phenomena, last generation pharmaceutical carriers (nanopharmaceuticals), in vitro and in vivo bioequivalence studies, biopharmaceuticals, pharmacogenomics, drug-drug and food-drug interactions, and in silico and in vitro prediction of ADME properties. In comparison with other similar textbooks, around half of the volume would be focused on the relationship between expanding scientific fields and ADME processes. Each of these burgeoning fields has a separate chapter in the second part of the volume, and was written with leading experts on the correspondent topic, including scientists and academics from USA and UK (Duquesne University School of Pharmacy, Indiana University School of Medicine, University of Utah College of Pharmacy, University of Maryland, University of Bath). Additionally, each of the initial chapters dealing with the generalities of drug absorption, distribution, metabolism and excretion would include relevant, classic examples related to each topic with appropriate illustrations (e.g. importance of active absorption of levodopa, implications in levodopa administration, drug drug interactions and food drug interactions emerging from the active uptake; intoxication with paracetamol as a result of glutathione depletion, CYP induction and its relationship with acute liver failure caused by paracetamol, etc). ADME Processes and Pharmaceutical Sciences is written as a core textbook for ADME processes, pharmacy, pharmacokinetics, drug delivery, biopharmaceutics, drug disposition, drug design and medicinal chemistry courses.<br/>::Contents##<br/>Part 1 The Basics of ADME Processes<br/>Introduction ADME Processes and Their Relationship with Pharmaceutical Practice<br/>Drug Release<br/>Drug Adsorption<br/>Drug Excretion.-Routes of Administration<br/>Part 2 The Importance of ADME Properties in Burgeoning Pharmaceutical Topics<br/>Nanotechnology and Drug Delivery<br/>Pharmacogenomics and Indiviualized Therapy<br/>Bioavailability and Bioequivalence Studies<br/>The Absorption and Distribution of Biopharmaceuticals/Biological Medical Products<br/>Drug-Drug and Food-Drug Interactions of Pharmacokinetic Nature<br/>In silico and In vitro ADME prediction<br/>Drug Transporters and Multi-drug Resistance.

::Summary## Traces the author's post-retirement work as a surgeon and teacher in such remote areas as Nepal and Ukraine, illuminating the challenges of working in difficult regions and finding purposeful work after a career.<br/>::Contents##<br/>The lock-keeper's cottage<br/>London<br/>Nepal<br/>America<br/>Awake craniotomy<br/>The mind-brain problem<br/>An elephant ride<br/>Lawyers<br/>Making things<br/>Broken windows<br/>Memory<br/>Ukraine<br/>Sorry<br/>The red squirrel<br/>Neither the sun nor death.

::Summary## This concise guide takes a practical approach to adolescent and young adult (AYA) rheumatology, aiming to cover the needs of any healthcare professional dealing with young people aged 10-24 years. Each chapter contains key management points for readers to readily access disease-specific management as well as highlighting specific AYA issues which differ from pediatric and adult practice. The coverage is comprehensive but concise and designed to act as a primary reference tool for subjects across the field of rheumatology. The book is designed for pediatric/adult rheumatologists, primary care physicians, nurses, allied health professionals and other professionals to understand each topic covered and to take a practical approach to to delivering developmentally appropriate rheumatology health care.

::Summary## This reader-friendly book takes a practical approach to caring for the adolescent athlete. Logically organized by joint, experts in sports medicine address both chronic and acute injuries in addition to congenital conditions.

::Summary## "The Adolescent Community Reinforcement Approach (A-CRA) is an evidence-based, developmentally-appropriate behavioral treatment for youth and young adults ages 12 to 25 years old with substance use disorders and related problems. Listed in several state and federal registries, including the National Registry of Evidence-Based Programs and Practices, A-CRA clinicians help youth and parents increase the family, social, and educational/vocational reinforcers to support recovery. Written by Drs. Susan H. Godley, Jane Ellen Smith, Robert J. Meyers, and Mark D. Godley, the principal researchers and experts in A-CRA, The Community Reinforcement Approach: A Clinical Guide for Treating Substance Use Disorders provides behavioral and mental health professionals with the detailed guidance needed to implement this evidence-based treatment"--Page [4] of cover.

::Summary## AMSTARs: Adolescent Contraception: Basics and Beyond highlights the fundamental aspects of contraception with an overview of contraceptive methods and epidemiology, provides up-to-date guidance on medical eligibility criteria, and reviews critical policy advances supporting contraceptive access.

::Summary## Adolescent Dating Violence: Theory, Research, and Prevention summarizes the course, risk/protective factors, consequences and treatment/prevention of adolescent dating violence. Dating violence is defined as physical, sexual, psychological, and cyber behavior meant to cause emotional, physical, or social harm to a current or former intimate partner. The book discusses research design and measurement in the field, focuses on the recent influx of longitudinal studies, and examines prevention and intervention initiatives. Divided into five sections, the book begins by reviewing theory on and consequences of dating violence. Section II discusses risk factors and protective factors such as peer influences, substance use, and past exposure to violence in the family of origin. Section III discusses how social and cultural factors can influence teen dating violence, addressing the prevalence of dating violence among different ethnicities and among LGBTQ teens, and the influence of social media. Section IV discusses recent research priorities including gender inequality, measurement, psychological abuse, and the dual nature of dating violence during adolescence. Section V reviews evidence-based practice for treatment and prevention across various age groups and settings.<br/>::Contents##<br/>Section I. Theory and consequences<br/>Section II. Risk and protective factors<br/>Section III. Social and cultural influences<br/>Section IV. Research priorities<br/>Section V. Treatment and prevention.

::Summary## "This book offers a comprehensive and clinically relevant survey of adolescent gynecology. Adolescent Gynecology: A Clinical Casebook addresses the many intersecting considerations of gynecologic and reproductive health care for this population using a concise, case-based format. Organized in four sections, the first introduces chapters on adolescent confidentiality, puberty, and well care. Section II covers varied menstrual disorders, while Section III highlights issues in reproductive health care including sexually transmitted infection and adolescent pregnancy. Finally, Section IV addresses special populations of adolescents, including chapters on girls who have sex with girls, girls who are victims of abuse and girls with special health care needs and chronic health conditions. In each section common gynecologic health issues are discussed in the context of these clinical cases, provide the knowledge needed to further improve comprehensive care of adolescent patients.Adolescent Gynecology: A Clinical Casebook is a unique resource that delivers essential clinical information for Adolescent Medicine and Pediatric and Adolescent Gynecology fellowship trainees, as well as for medical students, resident trainees, and primary care practitioners who are the front-line caregivers for adolescent girls"--Provided by publisher.<br/>::Contents##<br/>SECTION 1. General and Developmental Approach to Adolescents<br/>1. Case of a Girl with a Secret<br/>2. Case of a Girl Due for HPV Immunization<br/>3. Case of a Girl with Delayed Puberty and Inflammatory Bowel Disease<br/>4. Case of a Girl with Vulvar Swelling<br/>5. Case of a Girl with an Ovarian Cyst and Abdominal Pain<br/>SECTION 2. Menstrual Disorders<br/>6. Case of a Girl with Irregular Periods, Acne and Hirsutism<br/>7. Case of a Girl with Painful Periods, Pain with Bowel Movements and Dyspareunia<br/>8. Case of a girl with heavy, prolonged periods and anemia<br/>9. Case of a girl with irritability and mood swings with her periods<br/>10. Case of a girl with secondary amenorrhea and an eating disorder<br/>11. Case of a Girl with Primary Amenorrhea, Cyclic Pelvic Pain, and Absent Vagina<br/>12. Case of a Girl with Primary Amenorrhea, Delayed Puberty and High Gonadotropin levels<br/>SECTION 3. Sexually Active Adolescents<br/>13. Case of a Girl with Vaginal Discharge Who Has Sex with Boys<br/>14. Case of a Girl with Vaginal Discharge Who Has Sex with Girls<br/>15. Case of a Girl with Lower Abdominal Pain<br/>16. Case of a Girl with Vulvar Ulcers<br/>17. Case of a Girl with a Positive Pregnancy Test<br/>18. Case of a Girl Seeking Birth Control<br/>19. Case of a Girl with Condom Failure<br/>20. Case of a Girl with Obesity Seeking Birth Control<br/>21. Case of a Girl on Psychotropic Medications Seeking Birth Control<br/>SECTION 4. Special Populations of Adolescents<br/>22. Case of a Sexually Active Girl with Immune Compromise on Teratogenic Medications<br/>23. Case of a Girl Seeking Fertility Counseling<br/>24. Case of Girl with Special Needs Seeking Menstrual Management<br/>25. Case of a Girl with Chronic Abdominal Pain, Frequent Emergency Room Visits and Opioid Abuse.

::Summary## This book presents a detailed and updated review of the widespread changes that take place during adolescence, adopting a preventive perspective that reflects physical, social, cognitive, and emotional changes. It addresses a broad range of aspects, including: the preventive programs and their systemic effects; the role of environment in influencing the healthy behaviors of adolescents and young adults; the use of e-Health technology in health and behavioral interventions for adolescents; and the clinical and prognostic implications of primordial prevention in healthy adolescents. All of these elements are subsequently reviewed using a multidimensional approach, in order to offer extensive information on the complex changes that characterize adolescents' physiological, psychological, and neurobiological development. In addition, the book depicts the preventive strategies currently used in various social settings (school, family, sport club, health policies) aimed not only at reducing lifestyle risk behaviors, but also at improving resilience, happiness, social involvement, self-esteem, and sociability. This update is essential in the light of the fact that, to date, prevention has mainly been directed towards adolescents with physical or mental disorders rather than their healthy peers. As such, the book offers a valuable tool for pediatricians, child and adolescents psychiatrists, and for all professionals involved in Health Promotion and Disease Prevention.<br/>::Contents##<br/>Part I: Primordial prevention: General Aspects<br/>1. Preventive strategies: past, present and future<br/>2. Fetal Programming of Adult Disease in a Translational Point of View<br/>3. Physical activity and wellbeing<br/>4. Dietary habit and quality<br/>5. Biochemical markers in primordial prevention: premises and promises<br/>Part II: Adolescents' mental health and well-being<br/>6. Perinatal influences on neurodevelopment: The role of epigenetics<br/>7. The role of environmental enrichment on neurodevelopment<br/>8. Relationship between emotions, sleep and wellbeing<br/>9. Empowering adolescents with life skills education<br/>Part III: Adolescence and the Social Determinants of Health<br/>10. Family and Community<br/>11. School<br/>12. Peers<br/>Part IV: The digital era in adolescent's health and well-being<br/>13. Adolescence between past and future<br/>14. e-Health strategies<br/>15. Experiences and perspectives of the game in health programs: controversial issues<br/>16. New perspectives for multidisciplinary and integrated strategies of adolescent health and wellbeing.

::Contents##<br/>1. Introduction<br/>2. Description of the Disorder<br/>3. Theoretical Models and Rationale<br/>4. Diagnosis and Treatment Indications<br/>5. Treatment<br/>6. Adolescent Identity Treatment (AIT) Case Illustration<br/>7. Efficacy<br/>8. Training and Supervision.

::Summary## Adolescents have unique nutritional needs when compared to young children and adults. As youth go through physical, cognitive, and behavioral development, nutrition needs are dynamic and changing. If these needs go undetected and remain unaddressed, the results can derail physical and social maturation and include life-long effects on health. This comprehensive text offers a multidisciplinary perspective on aspects of adolescent nutrition. Using clinical cases, it covers relevant topics related to adolescent health including normal development, chronic health conditions, and complex biopsychosocial dynamics, among others. The first section of the text contains an overview of adolescent nutrition that is further broken down into more specific topics such as developmental nutrition needs, needs of active youth and athletes and media influences on body image. The next section focuses on health disparities such as culturally appropriate care, health equity, international considerations and food insecurity. The following section specifically addresses eating disorders ranging from anorexia and bulimia to binge eating. Finally, the last section covers additional health considerations such as polycystic ovarian syndrome, teen pregnancy, substance use and gender non-conforming youth. Written by experts in the field, this book is a helpful resource for primary care medical providers, registered dietitians, adolescent medicine specialists as well as advanced practice nurses, physician assistants and athletic trainers.<br/>::Contents##<br/>Part I General Adolescent Nutrition<br/>1. General Adolescent Development<br/>2. Confidentiality<br/>3. Communication and Adolescents<br/>4. Developmental Nutrition<br/>5. Wellness and Excessive Weight Gain<br/>6. Ensuring Nutritional Adequacy in the Adolescent and Young Adult Athlete<br/>7. Media Influences on Body Image & Eating Behaviors in Adolescents<br/>Part II Caring for Diverse Populations<br/>8. Supporting & Promoting Adolescent Nutritional Health Equity<br/>9. Food Insecurity Among Adolescents and Emerging Adults<br/>10. Culturally Appropriate Care<br/>11. International Considerations<br/>12. Health at Every Size®<br/>13. Juvenile Justice<br/>Part III Disordered Eating<br/>14. Anorexia Nervosa<br/>15. Bulimia Nervosa<br/>16. Avoidant/Restrictive Food Intake Disorder (ARFID).-17. Binge Eating Disorder in Adolescents and Emerging Adults<br/>18. Otherwise Specified and Unspecified Feeding or Eating Disorders<br/>19. Co-occurring Eating Disorders and Type 1 Diabetes Mellitus<br/>20. Co-Occurring Eating Disorders and Orthorexia Nervosa<br/>Part IV Additional Health Considerations<br/>21. Polycystic Ovarian Syndrome (PCOS)<br/>22. Type 1 Diabetes Mellitus<br/>23. Type II Diabetes Mellitus<br/>24. Nutrition in Adolescent Pregnancy<br/>25. Adolescent Substance Use<br/>26. Nurturing Healthy Transitions: Nutrition, Exercise, and Body Image for Transgender and Gender Diverse Youth.

::Summary## This volume presents a comprehensive and practical approach to the treatment of suicide and NSSI for adolescents utilizing a mentalizing framework. The beginning of the text provides up-to-date information on the theory of a mentalizing therapy in order to ground the readers in the neuroscientific underpinnings of a mentalizing approach. Next chapters provide information on the fundamental building blocks of a mentalizing therapy at the individual and family level. These chapters provide step-by-step approaches in order to provide examples of the techniques involved in mentalizing treatment that can be employed to address suicidality and NSSI. The next chapter builds on these concepts as the reader learns about mentalizing failures involved in common co-morbidities in adolescents who are experiencing suicidality and/or employing NSSI. The next several chapters cover practical issues related to working within this patient population including the key concept of social systems and connections for both providers and adolescents, the ability of mentalizing theory and therapy to integrate with other effective therapies, how to approach sessions after a suicide attempt, resiliency for patient, family and the provider, along with important self-care for a therapist if a patient commits suicide. The final chapter brings all of the aforementioned elements together in order for the reader to conceptualize employing a mentalizing approach to adolescents and their families when suicide and NSSI concerns are a predominate focus of care. Illustrations of specific therapeutic approaches and a list of resources and guidelines where available are also included. Adolescent Suicide and Self-Injury is an excellent resource for all clinicians working with youths at risk for suicide and/or self-injury, including psychiatrists, psychologists, pediatricians, family medicine physicians, emergency medicine specialists, social workers, and all others.<br/>::Contents##<br/>Intro<br/>Contents<br/>Contributors<br/>1: What Is Mentalizing?<br/>Introduction<br/>Brief History<br/>The Four Dimensions<br/>Whose Mental State? Self Versus Other<br/>What Kind of Mental State? Affective Versus Cognitive<br/>What Kind of Cues Are Used? Internal Versus External<br/>How Does the Awareness Come About? Automatic Versus Controlled<br/>The Development of Typical Mentalizing<br/>The Normative Timeline<br/>The Importance of Parenting and Attachment<br/>The Development of Atypical Mentalizing<br/>The Alien Self<br/>Pre-mentalizing Modes: The Target of Treatment<br/>Conclusion<br/>References 2: Core Mentalizing Techniques<br/>Introduction<br/>The Mentalizing Stance<br/>"Not Knowing"<br/>Holding the Balance<br/>Disengaging from Non-mentalizing<br/>Highlighting and Promoting Mentalizing<br/>Psychic Equivalence<br/>Teleological Mode<br/>Pretend Mode<br/>Notice and Name: The Mentalizing Loop<br/>Conclusion<br/>Suggested Reading<br/>3: Mentalizing in Family Work<br/>Introduction<br/>Case Introduction<br/>Initial Family Mentalizing Assessment and Formulation<br/>Example Formulation<br/>Promoting the Mentalizing Stance in Therapy<br/>Holding the Balance: Curiosity Holding the Balance: Slowing Down/Emotion Regulation<br/>Holding the Balance: The Affect Focus<br/>Holding the Balance: The "Here and Now" Focus<br/>Holding the Balance: Perspective-Taking<br/>Highlighting Good or Improved Mentalizing: Humility<br/>Highlighting Good or Improved Mentalizing: Humor<br/>Highlighting Good or Improved Mentalizing: Impact Awareness<br/>Highlighting Good or Improved Mentalizing: Forgiveness<br/>Disengaging from Non-mentalizing: Psychic Equivalence<br/>Disengaging from Non-mentalizing: Pretend Mode<br/>Disengaging from Non-mentalizing: Teleological Mode<br/>The Mentalizing Loop Psychic Equivalence: "Open Door?"<br/>Pretend Mode: The "Ferris Wheel"<br/>Teleological Mode: "Lecture Voice"<br/>Conclusion<br/>References<br/>4: Mentalization-Based Treatment Activities, Games, and Intersession Activities<br/>Introduction<br/>Introducing the Other (Introduction, a Challenge for Pretend Mode)<br/>The Pause Button (a Challenge for Psychic Equivalence or Teleological Mode)<br/>Inverted Roles Activity (All Three Mentalizing Failures)<br/>The "Feeling and Doing" Activity (Pretend Mode)<br/>Family Modeling (Pretend Mode, General Lack of Knowledge)<br/>The Mind [or Brain] Scan (Pretend Mode General Lack of Mentalizing)<br/>Safety, Timing, and Communicating About Games/Activities<br/>Modeling the Mentalizing Stance, Playfulness, Humility, and Use of Humor<br/>Troubleshooting Avoidance of Games<br/>Conclusion<br/>References<br/>5: Suicidality in Context<br/>Introduction<br/>Childhood Trauma<br/>Maltreatment Disrupts Mentalizing, Attachment, and Trust<br/>How Can Therapists Work Productively with Youth Who Have Suffered Maltreatment?<br/>Bullying<br/>Personality Factors<br/>Borderline Personality Disorder<br/>Narcissism<br/>Antisocial Personality Disorder<br/>Internalizing Disorders

::Contents##<br/>Adolescent and transitional urology : an introduction<br/>Anatomical and cystic anomalies<br/>Stones<br/>Prune-belly syndrome<br/>Renal function in adolescents<br/>Structural anomalies and reconstruction of the ureter<br/>Vesico-ureteric reflux<br/>The neuropathic bladder and spina bifida<br/>Lower urinary tract replacement and reconstruction<br/>Urinary diversion and undiversion<br/>Other bladder conditions<br/>Exstrophy and epispadias<br/>Cloacal exstrophy<br/>Posterior urethral valves<br/>Hypospadias<br/>Scrotal abnormalities<br/>The overvirilized female<br/>The undervirilized male<br/>Adolescent sexuality and counseling<br/>Neoplastic disease : outcomes in survivors.

::Summary## "Adolescence is a challenging stage for all individuals, especially for those with Autism Spectrum Disorder (ASD). Individuals with ASD face increased social isolation and engage in more challenging behaviors during adolescence. They also experience increased mental health challenges including anxiety and depression, and they are among the least likely of any disability group to attend college, be competitively employed, or live independently. At the same time, adolescents with ASD face a major shift in available services and support as they exit the K-12 educational system. The need to present what is known about this group in order to inform clinicians, researchers, and educators cannot be understated. Adolescents with Autism Spectrum Disorder synthesizes current science on adolescents and young adults with ASD in order to inform mental health practitioners and education professionals who work directly with these individuals. While early childhood interventions for ASD have been extensively developed and tested, research on adolescents and young adults with ASD has lagged behind until recently. This comprehensive handbook can be utilized to train students and professionals in applied mental health roles. The handbook includes three sections: Part I reviews diagnosis and treatment of adolescents with ASD; Part II details how to support their educational needs; and Part III discusses special populations including college students and young women. Chapters highlight recommendations for clinicians and include study questions and additional resources."-- Provided by publisher.<br/>::Contents##<br/>Part I. Diagnosis and Treatment of Adolescents with ASD<br/>Chapter 1: The Challenge of Entering Adulthood for Individuals with ASD<br/>Nicholas W. Gelbar and Daniel T. Volk<br/>Chapter 2: Efficacious Treatments for Common Psychiatric Challenges in Adolescents with Autism Spectrum Disorder<br/>Lisa A. Nowinski, Alyssa Milot, Alanna Gold, and Christopher J. McDougle<br/>Chapter 3: Executive functions in adolescents with Autism Spectrum Disorder<br/>Yael Dai and Inge-Marie Eigsti<br/>Chapter 4: Anxiety in Adolescents and Adults with ASD<br/>Micah O. Mazurek<br/>Chapter 5: Cognitive Behavioral Approaches for Treating Adolescents with ASD<br/>Caitlin M. Conner, Lindsey DeVries, and Judy Reaven<br/>Part II. Supporting Educational Needs of Adolescents with ASD<br/>Chapter 6: Self-Determination and the Transition to Adulthood for Youth and Young Adults with an Autism Spectrum Disorder<br/>Michael L. Wehmeyer and Karrie A. Shogren<br/>Chapter 7: Supporting Strong Transitions for Adolescents with Autism Spectrum Disorder<br/>Erik W. Carter<br/>Chapter 8: Employment Training for Young Adults with Autism Spectrum Disorder<br/>David W. Test, Debra G. Holzberg, Kelly Clark, Misty Terrell, and Dana E. Rusher<br/>Chapter 9: Teaching Skills to Adolescents Using Applied Behavior Analysis<br/>John Molteni<br/>Chapter 10: Managing Challenging Behavior in Adolescents with Autism Spectrum Disorder<br/>Maya Matheis, Jasper A. Estabillo, and Johnny L. Matson<br/>Part III. Special Populations of Adolescents with ASD<br/>Chapter 11: Supporting College Students with Autism Spectrum Disorder<br/>Nicholas W. Gelbar<br/>Chapter 12: Young Women on the Autism Spectrum<br/>Meng-Chuan Lai, Stephanie H. Ameis, and Peter Szatmari<br/>Chapter 13: Conclusion<br/>Nicholas W. Gelbar.

::Contents##<br/>Acute Dialysis Quality Initiative (ADQI) / Ronco, C., Kellum, J., Bellomo, R., Mehta, R.<br/>Implementation of novel biomarkers in the diagnosis, prognosis, and management of acute kidney injury : executive summary from the tenth consensus conference of the Acute Dialysis Quality Initiative (ADQI) / McCullough, P.A., for the Acute Dialysis Quality Initiative (ADQI) Consensus Group<br/>Diagnosis of acute kidney injury using functional and injury biomarkers : workgroup statements from the tenth Acute Dialysis Quality Initiative Consensus Conference / McCullough, P.A., for the ADQI 10 Workgroup<br/>Differential diagnosis of AKI in clinical practice by functional and damage biomarkers : workgroup statements from the tenth Acute Dialysis Quality Initiative Consensus Conference / Endre, Z.H., for the ADQI 10 Workgroup<br/>Use of biomarkers to assess prognosis and guide management of patients with acute kidney injury / Cruz, D.N., for the ADQI 10 Workgroup<br/>Physiological biomarkers of acute kidney injury : a conceptual approach to improving outcomes / Okusa, M.D., for the ADQI 10 Workgroup<br/>Pathophysiology of the cardiorenal syndromes : executive summary from the eleventh onsensus conference of the Acute Dialysis Quality Initiative (ADQI) / McCullough, P.A., for the Acute Dialysis Quality Initiative (ADQI) Consensus Group. Pathogenesis of cardiorenal syndrome type 1 in acute decompensated heart failure : workgroup statements from the eleventh consensus conference of the Acute Dialysis Quality Initiative (ADQI) / Haase, M., for the Acute Dialysis Quality Initiative (ADQI) Consensus Group<br/>Pathophysiology of cardiorenal syndrome type 2 in stable chronic heart failure : workgroup statements from the eleventh consensus conference of the Acute Dialysis Quality Initiative (ADQI) / Cruz, D.N., ; for the Acute Dialysis Quality Initiative (ADQI) Consensus Group<br/>Cardiorenal syndrome type 3 : pathophysiologic and epidemiologic considerations / Bagshaw, S.M., for the Acute Dialysis Quality Initiative 11 Working Group<br/>Cardiorenal syndrome type 4 : insights on clinical presentation and pathophysiology from the eleventh consensus conference of the Acute Dialysis Quality Initiative (ADQI) / Tumlin, J.A., for the Acute Dialysis Quality Initiative (ADQI) 11 Consensus Group<br/>Cardiorenal syndrome type 5 : clinical presentation, pathophysiology, and management strategies from the eleventh consensus conference of the Acute Dialysis Quality Initiative (ADQI) / Mehta, R.L., for the Acute Dialysis Quality Initiative (ADQI) 11 Working Group.

::Summary## Adrenal disorders are often difficult to diagnose due to common symptoms, and challenging to treat due to common comorbidities. Adrenal Disorders: 100 Cases from the Adrenal Clinic provides a comprehensive, case-based approach to the evaluation and treatment of both common and uncommon adrenal disorders, offering practical, real-world guidance highlighted by detailed laboratory evaluations, computed cross sectional images, nuclear medicine images, and gross pathology photographs. Features 100 two-page cases covering a wide range of common and uncommon adrenal disorders. Includes case report, investigations, treatment, and outcome for each case, plus a case overview with expert advice, take-home points, and references. Organizes comprehensive content by type of disorder, including adrenal masses (benign and malignant), primary aldosteronism, ACTH-independent Cushing syndrome, ACTH-dependent Cushing syndrome, adrenal carcinoma, pheochromocytoma, adrenal and ovarian hyperandrogenism, and adrenal disorders in pregnancy. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices-- Provided by publisher.

::Contents##<br/>1. Introduction<br/>2. Diagnostic assessment<br/>3. Diagnostic instruments<br/>4. Treatment<br/>5. Treatment: coaching adults with ADHD<br/>6. Setup and organization of a specialist department.

::Summary## This updated volume provides a clinical based overview of the assessment and treatment of ADHD in adults by a clinical researcher with extensive experience. Its practical focus allows each chapter to answer common questions encountered within clinical practice. Differential diagnosis of ADHD is also discussed in relation to comorbidity with bipolar disorder, borderline personality disorder, chronic fatigue syndrome, and chronic delayed sleep phase. Adult ADHD: Diagnostic Assessment and Treatment, fourth edition aims to help readers identify ADHD effectively and put in place suitable treatments. The book is relevant for psychiatrists, neurologists, and healthcare professionals involved in the diagnosis and treatment of adult ADHD.<br/>::Contents##<br/>1. Introduction<br/>2. Diagnostic Assessment<br/>3. Diagnostic Instruments<br/>4. Treatment<br/>5. Treatment: Coaching Adults with ADHD<br/>6. Setup and Organization of a Specialist Department.

::Summary## "This text reviews the anatomy and physiology of neuromodulation for treatment of various pathology of the human body, with specific emphasis on sacral neuromodulation for bladder and bowel dysfunction in the adult and pediatric populations. In addition to historical overview of the various methods of neuromodulation, present day applications will be discussed as well as possible future directions for use. Adult and Pediatric Neuromodulation will be of great value to medical professionals who are interested in the use of neuromodulation as a possible therapy option for their patients, particularly when other traditional or medical management options have failed. Each chapter is written by experts in the topic of various modalities of neuromodulation."-- Provided by publisher.

::Summary## This book elucidates the radiation therapy protocols and procedures for the management of adult patients presenting with primary benign and malignant central nervous system tumors. With the development of new treatment strategies and rapid advancement of radiation technology, it is crucial for radiation oncologists to maintain and refine their knowledge and skills. Dedicated exclusively to adult CNS radiation oncology, this textbook explores CNS tumors ranging from the common to the esoteric as well as secondary cancers of metastatic origin. The first half of the book is organized anatomically: tumors of the brain, spinal cord, leptomeninges, optic pathway, ocular choroid, and skull base. The second half covers primary CNS lymphoma, rare CNS tumors, metastatic brain disease, vascular conditions of the CNS, radiation-associated complications, and radiation modalities. Each chapter provides guidance on treatment field design, target delineation, and normal critical structure tolerance constraints in the context of the disease being treated. Learning objectives, case studies, and Maintenance of Certification Self-Assessment Continuing Medical Education-style questions and answers are incorporated throughout the book. This is an ideal guide for radiation oncologists, residents, and fellows, but medical students may also find value in the text.<br/>::Contents##<br/>Meningioma<br/>Pituitary Adenoma: Overview and Treatment Approaches<br/>Craniopharyngioma<br/>Vestibular Schwannoma<br/>Low Grade Glioma<br/>High Grade Gliomas<br/>Schwannomas and Neurofibromas<br/>Spinal Meningioma<br/>Astrocytic Tumors of Spinal Cord<br/>Spinal Cord Ependymoma<br/>Metastatic Epidural Spinal Cord Compression: Conventional Radiotherapy<br/>Vertebral Body Metastasis<br/>Evaluation and Workup of Leptomeningeal Disease<br/>Palliative Radiation Therapy for Leptomeningeal Disease<br/>Optic Pathway Gliomas<br/>Optic Nerve Sheath Meningioma<br/>Uveal Melanoma<br/>Skull Base Tumors<br/>Combined Modality Therapy for Primary Central Nervous System Lymphoma<br/>Choroid Plexus Tumors<br/>Hemangiopericytoma<br/>Stereotactic Radiosurgery for Hemangioblastomas<br/>NF2 Related Tumors and Malignant Peripheral Nerve Sheath Tumors<br/>Germ Cell Tumors<br/>Pineal Region Tumors<br/>Glomus Tumors<br/>Adult Medulloblastoma<br/>Intracranial Ependymoma<br/>Central Neurocytoma<br/>Prognostic Classification Systems for Brain Metastases<br/>Neurosurgical Management of Single Brain Metastases<br/>Multiple Brain Metastases<br/>Postoperative Treatment for Brain Metastasis<br/>Vascular Malformation Radiosurgery<br/>Adult CNS Radiation Oncology: Trigeminal Neuralgia<br/>Brain Radionecrosis<br/>Spinal Cord Tolerance and Risk of Radiation Myelopathy<br/>Radiation Optic Neuropathy<br/>Cerebral Atrophy and Leukoencephalopathy Following Cranial Irradiation<br/>Hypopituitarism<br/>Neurocognitive Changes<br/>Cranial Nerve Palsies, Vascular Damage, and Brainstem Injury<br/>Conformal Therapy and Intensity Modulated Radiation Therapy/Volumetric Modulated Arc Therapy<br/>Linac Based Stereotactic Radiosurgery and Hypofractionated Stereotactic Radiotherapy<br/>Gamma Knife® Stereotactic Radiosurgery and Hypo-Fractionated Stereototatic Radiotherapy<br/>Spinal Stereotactic Body Radiotherapy<br/>Proton Beam Therapy (For CNS Tumors)<br/>Brachytherapy.

::Contents##<br/>Part 1. Introduction to adult congenital heart disease<br/>Part 2. Specific lesions<br/>Part 3. General management issues of adult congenital heart disease.

::Summary## This book describes the most popular topics concerning adult congenital heart disease (ACHD), especially focusing on indications and re-intervention procedures for some major ACHDs. Thanks to advances in medical and surgical therapy for congenital heart disease over the last half century, many patients who underwent surgical correction reached adulthood. However, as can be seen from the explosive increase in the number of ACHD patients, postoperative residua and sequelae have also become apparent. The purpose of this book is to highlight complicated problems in connection with ACHD, including its present status, as well as methods for its management including medical and surgical treatment. The content primarily focuses on two areas - general information for cardiologists, and information on re-intervention for interventionists and cardiac surgeons -, setting it apart from the majority of books on congenital heart disease.<br/>::Contents##<br/>Part I: Background and Facilities<br/>Chapter 1: Historical perspective<br/>Chapter 2: Facilities for patients' care<br/>Part II: Medical consideration<br/>Chapter 3: Post-operative residua and sequelae<br/>Chapter 4: Heart failure<br/>Chapter 5: Rhythm disturbance / sudden death<br/>Part III: Intervention / Re-intervention considerations<br/>Chapter 6: Anesthesia for ACHD<br/>Chapter 7: Therapeutic catheter intervention (ASD, PDA, CoA, etc)<br/>Chapter 8: Repaired tetralogy of Fallot<br/>Chapter 9: Post RV-PA conduit repair (PA + VSD, TGA III, etc)<br/>Chapter 10: Repaired complete transposition of the great arteries<br/>Chapter 11: Corrected TGA<br/>Chapter 12: Post right heart bypass operation<br/>Chapter 13: Aortopathy including hereditary disease (Marfan syndrome, bicuspid aortic valve, etc)<br/>Chapter 14: Ebstein anomaly.

::Summary## There is an evident practice gap in education of general adult cardiologists on long-term management of congenital heart disease (CHD). The goal of this book is to help general cardiologists, but also pediatricians and related care providers in the management and diagnosis of adult CHD. Adult Congenital Heart Disease in Clinical Practice provides clear, practical advice on adult CHD for the busy fellow, resident and practicing clinician. It includes training and revision material to assist learning and is formatted in such a way as to provide short, concise content designed for easy recall of salient facts.

::Summary## This volume focuses on adult craniopharyngiomas, offering various perspectives. The first part of the book provides an up-to-date overview of the pathogenesis and management of adult craniopharyngiomas, helping readers understand the pathogenesis and molecular pathways. It highlights the importance of animal models for addressing molecular keys and for developing targeted therapies. The second part deals with clinical management, detailing the latest results in the era of endoscopic surgery, including the major contribution of the extended nasal endoscopic approaches for suprasellar and retrochiasmatic tumors. The book also discusses the key aspects of these tumors and how to manage them. The last part of the book addresses the future therapies and recurrences after surgery and radiotherapy. This volume is of interest to neurosurgeons, endocrinologists, paediatricians, radiologists and oncologists.<br/>::Contents##<br/>Intro<br/>Foreword 1<br/>Foreword 2<br/>Acknowledgement<br/>Contents<br/>1: Histopathology and Molecular Pathology of Craniopharyngioma in Adults<br/>1.1 Introduction<br/>1.2 Adamantinomatous Craniopharyngioma<br/>1.2.1 Histopathology<br/>1.2.1.1 Histopathological Features<br/>1.2.1.2 Regressive Changes and Surrounding Nervous Tissue<br/>1.2.2 Molecular Pathology<br/>1.2.3 ACP and Odontogenesis<br/>1.3 Papillary Craniopharyngioma<br/>1.3.1 Histopathology<br/>1.3.2 Molecular Pathology<br/>1.3.3 Origin of PCP<br/>1.4 Mixed and Collision Tumors<br/>1.5 Malignant Transformation in Craniopharyngiomas 1.6 Differential Diagnosis<br/>1.6.1 ACP and Pilocytic Astrocytoma<br/>1.6.2 PCP and Rathke's Cleft Cyst with Squamous Metaplasia<br/>1.6.3 ACP and Sellar Xanthogranuloma<br/>1.6.4 ACP Versus PCP<br/>1.6.5 Cystic ACP and Rathke's Cleft Cysts<br/>1.7 Conclusion<br/>References<br/>2: Mouse Models of Craniopharyngioma<br/>2.1 Genetically Engineered Mouse Models (GEMMS) of Craniopharyngioma<br/>2.1.1 Adamantinomatous Craniopharyngioma<br/>2.1.2 Embryonic Model of Human ACP<br/>2.1.3 Inducible Model of Human ACP 2.2 Stem Cell Paracrine Tumourigenesis: A Novel Mechanism of Somatic Stem Cells Contribution to Tumour Formation<br/>2.3 Childhood-Onset Craniopharyngioma is a Developmental Disorder<br/>2.4 Cluster Cells Are Molecularly Similar and Share a Signature of Cellular Senescence<br/>2.5 Papillary Craniopharyngioma and Adamantinomatous Craniopharyngioma are Distinct Tumour Entities<br/>2.6 Patient-Derived Xenografts (PDXs) Models of Human Craniopharyngioma<br/>2.7 Therapeutic Lessons from Mouse Models<br/>2.8 Conclusion<br/>References 3: Epidemiology, Clinical Presentation, and Prognosis of Adult-Onset Craniopharyngioma<br/>3.1 History<br/>3.2 Epidemiology of Adult-Onset CP<br/>3.3 Clinical Presentation of Adult-Onset Craniopharyngioma<br/>3.3.1 Our series (Table 3.1)<br/>3.3.1.1 Ophthalmology<br/>3.3.1.2 Endocrine Symptoms<br/>3.3.1.3 Non-specific Symptoms<br/>3.3.1.4 Hypothalamic and Limbic Symptoms<br/>3.3.1.5 Radiology and Histology<br/>3.3.2 Literature<br/>3.3.2.1 Ophthalmology<br/>3.3.2.2 Endocrine<br/>3.3.2.3 Hypothalamic and Limbic Symptoms<br/>3.3.2.4 Other Symptoms 3.4 Long-Term Morbidity and Mortality in Treated Adult-Onset CP<br/>3.4.1 Morbidity<br/>3.4.1.1 Endocrine Morbidity<br/>3.4.1.2 Ophthalmologic Morbidity<br/>3.4.1.3 Hypothalamic Morbidity<br/>3.4.2 Mortality<br/>3.5 Modern Management of CP Improves Prognosis?<br/>3.6 Conclusion<br/>References<br/>4: Craniopharyngioma Diagnosis: A Rationale for Accurate MRI Assessment of Tumor Topography and Adhesion to the Hypothalamus<br/>4.1 Introduction. MRI Assessment of Craniopharyngiomas: What Essential Information Should a Neurosurgeon Obtain from It?

::Summary## This book is intended to offer a “virtual fellowship” in hip surgery that will give readers the opportunity to join distinguished hip surgeons in the operating room, learning key points and solutions to technical difficulties from the beginning to the end of 100 surgical cases. All of these cases have been carefully selected by renowned orthopaedists who work at the world’s top centers and perform surgery based on evidence. To facilitate quick learning, the cases are presented using a uniform template, guiding the reader from clinical evaluation and preoperative planning, through the decision-making process, to the surgical procedure and the final outcome. At the end of each case, the editor invites the surgeon to answer specific questions in order to further elucidate crucial issues with reference to current evidence. The book is divided into four sections: conservative hip surgery, primary hip arthroplasty, complex hip arthroplasty, and revision arthroplasty. It will be of value across the world to specialist hip surgeons and surgeons in training who are interested in hip surgery.

::Summary## "As knee replacement surgeries continue to grow in number worldwide, the need for an authoritative and comprehensive reference in this key area is a must for today's orthopaedic surgeon. The Adult Knee: Knee Arthroplasty, Second Edition, brings together the knowledge and expertise of internationally recognized experts in the field in one convenient volume. Covers knee biomechanics relevant to knee arthroplasty, alternatives to knee arthroplasty to alleviate arthritis, and primary total knee arthroplasty, including perioperative issues. Discusses complications including stiff knee, periprosthetic fractures, and instability, revision total knee arthroplasty, and management of infections in total knee replacement"-- Provided by publisher

::Contents##<br/>Defining Adult Lumbar Scoliosis<br/>Imaging Adult Lumbar Scoliosis<br/>Radiographic Parameters for Adult Lumbar Scoliosis<br/>Patient Reported Outcome Measures Available for Adult Lumbar Scoliosis<br/>Impact of Depression on the Treatment of Adult Lumbar Scoliosis<br/>Pre-Operative Clinical Evaluation of Adult Lumbar Scoliosis<br/>Non-Operative Management of Adult Lumbar Scoliosis<br/>Surgical Alignment Goals for Adult Lumbar Scoliosis<br/>Intra-Operative Management of Adult Lumbar Scoliosis<br/>Biologics for Adult Lumbar Scoliosis<br/>Assessing the Need for Decompression for Adult Lumbar Scoliosis<br/>Minimally Invasive Techniques for Adult Lumbar Scoliosis<br/>Anterior Column Release for Adult Lumbar Scoliosis<br/>Anterior Column Support Options for Adult Lumbar Scoliosis<br/>Releases and Osteotomies Used for the Correction of Adult Lumbar Scoliosis<br/>Distal Fixation for Adult Lumbar Scoliosis: Indications and Techniques<br/>Diagnosis and Classification of Proximal Junctional Kyphosis and Proximal Junctional Failure<br/>Prevention Strategies for Proximal Junctional Kyphosis<br/>Complications Following Surgical Intervention for Adult Lumbar Scoliosis<br/>Peri-Operative Patient Management of Adult Lumbar Scoliosis<br/>Patient Reported Outcomes Following the Treatment of Adult Lumbar Scoliosis<br/>Health Economic Value of the Treatment for Adult Lumbar Scoliosis<br/>Future Directions for Adult Lumbar Scoliosis.

::Contents##<br/>Speakers at the symposium<br/>Stem cells in adult intestine / Feng, J., Sperka, T.<br/>Molecular mechanisms of muscle stem cell aging / Schwërer, S., Tümpel, S.<br/>Mechanism of functional alterations in hematopoietic stem cell aging / Morita, Y.<br/>The microenvironment, aging, and disease / Geiger, H.<br/>Sestrins in aging and metabolism / Tang, D., Tao S.<br/>Telomeres and stem cell aging / Felix, D.A.<br/>DNA damage and checkpoint responses in adult stem cells / Romanov, V., Shukla, A., Ju, Z.

::Summary## This book provides essential information on the epidemiology, molecular and genetic features, anti-CCR4 antibody therapy and a nationwide study of transplantation on human T-leukemia virus type-I (HTLV-1) and adult T-cell leukemia/lymphoma (ATL). This rare but important disease has restricted endemic areas and distinct clinical features such as a high frequency of hypercalcemia, strong predisposition to infection and poor response to chemotherapy, aspects which set ATL apart from other types of non-Hodgkin lymphoma. Given the small number of patients, enrollment in clinical trials has not been feasible, and establishing treatment standard has been difficult but new evidence, such as results of nationwide studies on transplantation, have shown new insights and potential treatments. Based on recent evidence, the book presents new treatment methods for ATL and infection prevention of HTLV-1, enabling clinicians, researchers and post-docs specializing in hematology and virology to gain a valuable overview of the disease.

::Contents##<br/>Anatomy<br/>Ideal Shape of Umbilicus<br/>Classification<br/>History<br/>Position of Umbilicus<br/>Umbilical Reconstructive Techniques<br/>Melanoma<br/>Complications and Outcome.

::Summary## After introductory chapters devoted to the safe production and distribution of vaccines, the book addresses the question of adult vaccination in the framework of a life-course approach to vaccination. It presents the proceedings of multidisciplinary expert discussions with an excellent summary of the current state of knowledge on adult vaccination in various diseases, as well as an overview of the professionals involved and the obstacles to achieving greater vaccine uptake, and how these may be addressed. The book systematically discusses the major vaccine-preventable diseases, as well as regulatory issues in vaccine provision, and presents the results of an expert meeting designed to identify the obstacles to vaccination, and solutions for addressing these barriers. It goes on to extend the discussion beyond the traditional boundaries of human health to encompass the “one health” concept. The book is intended for all those with an interest in vaccination, including physicians (from a wide range of disciplines including geriatrics/gerontology, infectious diseases, pediatrics, internal medicine, and other non-organ specialties), other healthcare professionals, pharmacists, representatives of the pharmaceutical industry and regulatory bodies (EMEA, national authorities), policymakers, the media and the general public.

::Summary## Substitution and adulteration in traded herbal raw material are common practice in the herbal industry due to the extinction of required species, deforestation and incorrect taxonomical identification. Herbalists have adopted methods to create high quality adulteration which cannot be detected without performing microscopic examination or chemical analysis. It is difficult to establish specific quality control standards due to the complex nature and innate unpredictability of the chemical constituents of medicinal herbs.The main parameters for measurement and adulteration prevention in medicinal herbs are morphological and microscopic investigation, chemical profiling and DNA barcoding. The need for highly sensitive and more effective approaches for the authentication of medicinal herbs is necessary in order to promote the acceptance of herbal products. Adulteration In Traditional Medicinal Herbs is aimed at promoting awareness of adulteration in traditional herbal medicines for the worldwide scientific community. Parameters are established for the prevention of adulteration through classical and modern scientific tools. Valuable case studies are presented based on ethno-medicinal surveys performed in many herbal markets in Pakistan. Collections of various samples were obtained from these shops then compared with the original plants collected from field. Various phytochemical, organoleptic and DNA barcoding techniques were used in order to detect adulteration in the marketed herbal samples. This book is the first of its kind and is aimed at helping the scientific community to identify particular medicinal plants which are facing adulteration problems in herbal markets and to estimate the extent of adulteration and substitution in commonly used medicinal herbs.<br/>::Contents##<br/>CHAPTER 1: Adulteration A Global Issue<br/>CHAPTER 2: Types and Causes of Adulteration: Global Perspectives<br/>CHAPTER 3: Why Study Herbal Plants?<br/>CHAPTER 4: History, Classification, Worldwide Distribution and Significance of Herbal Plants<br/>CHAPTER 5: Marketed Herbal Drugs: How Adulteration Affects<br/>CHAPTER 6: Preventive Measures to Stop Adulteration in Marketed Herbal Samples<br/>CHAPTER 7: Medicinal Wealth of Pakistan<br/>CHAPTER 8: Marketed Herbal Plants in Pakistan: Case Studies<br/>CHAPTER 9: List of Commonly used Herbal Drugs throughout the World<br/>CHAPTER 10: A pictorial guide of marketed herbal plants: Comparison with the original sample.

::Summary## This volume gives an overview on the currently debated ethical issues regarding advance directives from an international perspective. It focuses on a wider understanding of the known and widely accepted concept of patient self-determination for future situations. Although advance directives have been widely discussed since the 1980s, the ethical bases of advance directives still remain a matter of heated debates. The book aims to contribute to these controversial debates by integrating fundamental ethical issues on advance directives with practical matters of their implementation. Cultural, national and professional differences in how advance directives are understood by health care professions and by patients, as well as in laws and regulations, are pinpointed.<br/>::Contents##<br/>History of Advance Directives and Prerequisites for Validity<br/>Defining the Scope of Advance Directives<br/>Effects on Family, Friends and Professional Relations<br/>Ethical Challenges.

::Summary## This text examines in detail mathematical and physical modeling, computational methods and systems for obtaining and analyzing biological structures, using pioneering research cases as examples. As such, it emphasizes programming and problem-solving skills. It provides information on structure bioinformatics at various levels, with individual chapters covering introductory to advanced aspects, from fundamental methods and guidelines on acquiring and analyzing genomics and proteomics sequences, the structures of protein, DNA and RNA, to the basics of physical simulations and methods for conformation searches. This book will be of immense value to researchers and students in the fields of bioinformatics, computational biology and chemistry. Dr. Dongqing Wei is a Professor at the Department of Bioinformatics and Biostatistics, College of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, China. His research interest is in the general area of structural bioinformatics.<br/>::Contents##<br/>Introduction to Structural Bioinformatics<br/>Modeling and Structure Determination<br/>The Structure Prediction of Biological Macromolecules<br/>The Biological Macromolecules in Computational Biology<br/>The Functional Analysis of Biological Macromolecules<br/>The Structure-Based Drug Design.

::Summary## This book provides novel arthroscopy techniques and applications to clinical practitioners, including sports medicine therapeutics, orthopaedic surgeons, specialist training candidates, rehabilitation clinicians. Small incisions per minimally invasive surgery using a camera mounted on a thin tube to visualize, repair and reconstruct joint-associated structures are accepted and welcomed by the sports medicine field. Arthroscopy technique as a minimally invasive surgical method, in Orthopeadics is not only for the treatment of intra-articular diseases but also an advanced conception for treatment of extra-articular diseases and peri-articular fractures. After performing years of arthroscopy, authors intend to provide an elite technique demonstration of each procedure, including indications, technique, complications, and results. There are three main parts of the book, including the extra-articular application of arthroscopy techniques, arthroscopic minimally invasive techniques for the treatment of intra-articular fractures, and Innovative technology for repair and reconstruction of bone and joint injuries. Key technical points and experience of arthroscopic repair of joint injuries, dislocation of joints, fixation of the intra-articular fractures, ligament release for limbs are illustrated. Special situations such as congenital torticollis, deltoid contracture, gluteal muscle contracture, bone grafting, removal of locking plate and screw and benign tumors treatment are also included.<br/>::Contents##<br/>Part 1 Application of arthroscopy technology outside joints<br/>1 Endoscopic release of congenital muscular torticollis with radiofrequency under local anesthesia<br/>2 Arthroscopic acromioclavicular arthroplasty for Acromioclavicular impingement<br/>3 Radiofrequency Micro-debridement under Arthroscopy for Tennis Elbow (Lateral Epicondylitis)<br/>4 Arthroscopic Transverse Carpal Ligament Release for Carpal Tunnel Syndrome<br/>5 Arthroscopic palmar membrane release for Dupuytren's disease<br/>6 Arthroscopic Release of the Deltoid Contracture<br/>7 Arthroscopic Gluteal Muscle Contracture Release with Radiofrequency Energy<br/>8 Removal of popliteal cyst under endoscopy<br/>9 Arthroscopic Curettage of Benign Bone Tumors<br/>10 Removal of plate and screws under endoscopy<br/>11 Minimally Invasive Arthroscopy for Achilles Tendinopathy<br/>12 Arthroscopic percutaneous suture of Achilles tendon ruptures<br/>13 Arthroscopic Minimally Invasive Surgery for Hallux Valgus Caused by Bunion<br/>Part 2 Arthroscopic minimally invasive technique for treatment of intra-articular fractures<br/>14 Arthroscopic prying reduction and fixation for the greater tuberosity fractures<br/>15 Arthroscopic reduction and fixation of bony bankart lesions<br/>16 Treatment of fracture of radial head with arthroscopic Prying reduction and fixation<br/>17 Arthroscopic treatment o of avulsion fracture of the tibial intercondylar eminence<br/>18 Treatment of tibial plateau fractures with Prying reduction and fixation under arthroscopy<br/>19 Arthroscopic poking reduction and fixation of ankle fractures<br/>Part 3 Innovative technology for repair and reconstruction of joint injuries<br/>20 Reconstruction of anterior cruciate ligament with tendon knot press fitted Technique<br/>21 Anterior Cruciate Ligament Reconstruction with Remnant Preserving Technique<br/>22 Femoral and Tibia Fixation with Cross-Pin System in Anterior Cruciate Ligament Reconstruction by using Semitendinosus and Gracilis<br/>23 Applying Allogenetic Cortical Bon e Press-fit Screw in Fixation of Anterior Cruciate Ligament Reconstruction<br/>24 Applying Allogenetic Cortical Bone Cross-pin in Fixation of Anterior Cruciate Ligament Reconstruction<br/>25 Bone bio-anchors for repairing rotator cuff tear<br/>26 Repair of Bankart leisure with biological bone anchors<br/>27 Autologous scapular bone block with bone allograft pins for bony Bankart leisure<br/>28 Arthroscopic Superior Capsular Reconstruction Using "Sandwich" Complex Patch graft for Irreparable Rotator Cuff Tears<br/>29 Clearance and radial head resection of Elbow joint of rheumatoid arthritis under arthroscopy<br/>30 Ankle arthrodesis under arthroscopy<br/>31 Debridement of Early Hip Joint Lesions in Ankylosing Spondylitis.

::Summary## Step by step, you'll hone your ability to perform effective health assessments, obtain valid data, interpret the findings, and recognize the range of conditions that can be indicated by specific findings to reach an accurate differential diagnosis. You'll have coverage of 170 conditions and symptoms across the lifespan at your fingertips.<br/>::Contents##<br/>Assessment and clinical decision-making : an overview<br/>Genomic assessment : interpreting findings and formulating differential diagnoses<br/>Skin<br/>Head, face, and neck<br/>The eye<br/>Ear, nose, mouth, and throat<br/>Cardiac and peripheral vascular systems<br/>Respiratory system<br/>Breasts<br/>Abdomen<br/>Genitourinary system<br/>Male reproductive system<br/>Female reproductive system<br/>Musculoskeletal system<br/>Neurological system<br/>Nonspecific complaints<br/>Psychiatric mental health<br/>Pediatric patients<br/>Pregnant patients<br/>Assessment of the transgender or gender diverse adult<br/>Older adults<br/>Persons with disabilities.

::Summary## "The probability for exposure to damaging radiation, toxic chemicals in the environment and adverse biological agents has increased exponentially today. The more frequent and faster travel that we experience today also escalates the risk of contraction and transmission of potentially deadly infections. This has created a very real and escalating risk for injuries and deaths. This is accentuated in the military and medical staff that is more frequently exposed to radiological, chemical, and biological agents in their normal working environment. Understanding the mechanisms whereby these toxic agents inflict damage to our bodies is essential to prepare us for these challenges. Much of the damage is inflicted through the generation of free radicals and non-radical oxidants which then act through oxidative mechanisms to injury the body. This volume will discuss the damage caused by these radiological, chemical, and biological environmental stressors, the mechanisms through which the damage can occur and the novel strategies that can be used to reduce the injury inflicted by these toxic compounds. Using basic and clinical research approaches, the contents of this book discuss new ideas for the development of bioactive products and environmental approaches to lessen or negate the biological damage inflicted by these noxious compounds."--Publisher's website.

::Contents##<br/>1. Frotiers for bulk nanostructured metals in biomedical applications<br/>2. Stimuli-responsive materials used as medical devices in loading and releasing of drugs<br/>3. Recent advances with liposomes as drug carriers<br/>4. Fabrication, properties of nanoshells with controllable surface charge and its applications<br/>5. Chitosan as an advanced healthcare material<br/>6. Chitosan and low molecular weight chitosan: biological and biomedical applications<br/>7. Anticipating behaviour of advanced materials in healthcare<br/>8. Label-free biochips<br/>9. Polymer MEMS sensors<br/>10. Assembly of polymers/metal nanoparticles and their applications as medical devices<br/>11. Combination of molecular imprinting and nanotechnology: beginning of a new horizon<br/>12. Prussian blue and analogues: biosensing applications in health care<br/>13. Efficiency of biosensors as new generation of analytical approaches at the biochemical diagnostics of diseases<br/>14. Nanoparticles: scope in drug delivery<br/>14. Smart polypeptide nanocarriers for malignancy therapeutics<br/>Index.

::Summary## "Advances in Cardiac Imaging presents the latest information on heart disease and heart failure, major causes of death among western populations. In addition, the text explores the financial burden to public healthcare trusts and the vast amount of research and funding being channeled into programs not only to prevent such diseases, but also to diagnose them in early stages. This book provides readers with a thorough overview of many advances in cardiac imaging. Chapters include technological developments in cardiac imaging and imaging applications in a clinical setting with regard to detecting various types of heart disease"--Provided by publisher.

::Contents##<br/>Part 1 Introduction<br/>Part 2 Systems of Care<br/>Part 3 Effective High-Performance Team Dynamics<br/>Part 4 The Systematic Approach<br/>Part 5 The ACLS Cases: Respiratory arrest case ; Acute coronary syndrome case ; Acute stroke case ; Cardiac arrest: VF/pulseless VT case ; Cardiac arrest: pulseless electrical activity case ; Cardiac arrest: asystole case ; Brachycardia case ; Tachycardia: stable and unstable ; Immediate post-cardiac arrest care case<br/>Appendix<br/>Index.

::Contents##<br/>Part 1: Overview of ACLS. Introduction ; Systems of care ; Systematic approach<br/>Part 2: Preventing arrest. Recognition: signs of clinical deterioration ; Acute coronary syndromes ; Acute stroke ; Bradycardia ; Tachycardia: stable and unstable<br/>Part 3: High-performance teams. High-performance team roles and dynamics ; Respiratory arrest ; Cardiac arrest: VF/pVT ; Cardiac arrest: PEA and asystole ; Cardiac arrest: selected special situations ; Post-cardiac arrest care<br/>Appendices: Testing checklists and learning station checklists ; ACLS pharmacology summary table ; Science summary table ; Glossary.

::Contents##<br/>Endoscopic Instruments<br/>Difficult Polpys: Conventional methods<br/>Endoscopic Mucosal Resection (EMR)<br/>Endoscopic Submucosal Dissection (ESD)<br/>Combined Endoscopic and Laparoscopic Surgery (CELS)<br/>Colonic Stenting<br/>Endoscopic Treatment of Perforations of Fistulas.

::Contents##<br/>History of Colonoscopy<br/>Anatomic Basis of Colonoscopy<br/>Colonoscopy Photo Atlas<br/>How to Achieve High Rates of Bowel Preparation Adequacy<br/>Patient comfort during colonoscopy<br/>VTE Prophylaxis: How to optimize patients on anticoagulation and avoid infectious complications<br/>Endoscopic Equipment and Instrumentation<br/>Basic Colonoscopic Techniques to Reach the Cecum<br/>Basic Colonoscopic Interventions: Cold, Hot Biopsy Techniques, Submucosal Injection, Clip Application, Snare Biopsy<br/>Current Guidelines for Colonoscopy<br/>Difficult Colonoscopy: tricks and new techniques for getting to the cecum<br/>How to recognize, characterize, and manage premalignant and malignant colorectal polyps<br/>Detection: (CQI) Quality measures and tools for improvement<br/>Advanced endoscopic imaging: polyps and dysplasia detection<br/>Endoscopic Mucosal Resection (EMR)<br/>Endoscopic Mucosal Dissection<br/>Applications of intra-operative endoscopy<br/>Combined Endoscopic and Laparoscopic Surgery (CELS)<br/>Endoluminal Colorectal Stenting<br/>How to Avoid Complications/Treatment of Endoscopic Complications<br/>Alternative Colorectal Imaging<br/>Current Endoluminal Approaches: Transanal Endoscopic Microsurgery, Transanal Minimally Invasive Surgery and Transanal Total Mesorectal Excision.

::Summary## In this book, leading international specialists in the field join forces to discuss topics, issues, and approaches that are of key importance in the optimal treatment of lumbar degenerative disk disease. The coverage is wide ranging, from current understanding of physiopathology and genetics and modern imaging techniques through to the diverse minimally invasive, non-fusion, and fusion surgical techniques. Detailed attention is drawn to the most important aspects to be considered when approaching the patient and making treatment decisions. The role of conservative management is appraised, and surgical techniques and their indications are carefully described. Emphasis is placed on the importance of sagittal balance for treatment success. Among the various other subjects covered are psychosocial issues, legal aspects, outcome evaluation, and the relative merits of evidence-based medicine and individual experience. In the concluding section, some of the top specialists from across the world reflect on the lessons that they have learned during lifetimes in spinal surgery. Advanced Concepts in Lumbar Degenerative Disk Disease is intended as the definitive book on this important subject. It will be an instructive and fascinating source of information for all spine surgeons and other spine care providers.

::Summary## In this book, international experts present up-to-date techniques of otoplasty in which they have extensive personal experience. Both new and modified procedures are described with the aid of a wealth of high-quality illustrations. In addition to these detailed descriptions, ear embryology and anatomy, psychological issues, postoperative care, possible risks and complications, and outcomes are extensively covered in order to provide the reader with a state of the art account of all aspects of cosmetic otoplasty.<br/>::Contents##<br/>Part I. Anatomy<br/>Part II. Preoperative<br/>Part III. Techniques<br/>Part IV. Postoperative<br/>Part V. Complications of otoplasty<br/>Part VI. Outcomes<br/>Part VII. Miscellaneous.

::Summary## Learn to effectively address life-threatening and potentially life-threatening patient conditions, with Advanced Critical Care Nursing, 2nd Edition. Endorsed by the American Association of Critical-Care Nurses (AACN), this comprehensive, nursing-focused text centers on the clinical reasoning process as it helps you comprehend, analyse, synthesize, and apply advanced critical care knowledge and concepts. The book is organized within the structure of body systems along with synthesis chapters that address patient conditions involving multiple body systems. Numerous illustrations and graphs plus unfolding case studies further aid your understanding and help you apply text content. In all, Advanced Critical Care Nursing is the must-have resource dedicated to helping you oversee or care for critical care patients in any practice setting. -- Provided by publisher.<br/>::Contents##<br/>The Evolving Critical Care Environment<br/>Advanced Dysrhythmias<br/>Acute Coronary Syndromes<br/>Heart Failure<br/>Cardiac Surgery<br/>Valvular Disease and Surgery<br/>Vascular Emergencies<br/>Heart and Lung Transplantation<br/>Acute Respiratory Failure and Acute Lung Injury<br/>Mechanical Ventilation and Weaning<br/>Thoracic Surgery<br/>Head Injury and Dysfunction<br/>Cerebrovascular Disorders<br/>Spinal Cord Injury<br/>Special Neurologic Patient Populations<br/>Gastrointestinal Bleeding<br/>Liver Dysfunction and Failure<br/>Pancreatitis<br/>The Gut in Critical Illness<br/>Liver, Kidney, and/or Pancreas Transplantation<br/>Electrolyte Emergencies<br/>Complex Acid-Base Disorders and Associated Electrolyte Imbalances<br/>Acute Renal Failure<br/>Glycemic Control<br/>Pituitary, Thyroid, and Adrenal Disorders<br/>Blood Conservation / Blood Component Replacement<br/>Coagulopathies<br/>Shock and End Points of Resuscitation<br/>Optimizing Hemodynamics: Strategies for Fluid and Medication Titration in Shock<br/>Trauma and Mass-Casualty Competencies<br/>Systemic Inflammatory Response Syndrome and Multiple Organ Dysfunction Syndrome<br/>Caring for the Immunocompromised Patient<br/>Caring for the Patient in the Immediate Postoperative Period<br/>Caring for the Critically Ill Pregnant Patient<br/>Caring for the Pediatric Patient in an Adult Critical Care Unit<br/>Caring for the Critically Ill Elderly Patient<br/>Caring for the Critically Ill Patient with a Neuropsychiatric Disorder<br/>Caring for the Bariatric Patient<br/>Pain and Sedation<br/>Comorbid Conditions<br/>Oncologic Emergencies<br/>Chemical Dependency<br/>End-of-Life Care<br/>Appendix A: Answers to Decision Point Questions.

::Contents##<br/>1 Advanced Glaucoma Surgery: An Overview<br/>2 Trabecular Micro-bypass Stent for the Treatment of Co-existent Cataract and Mild Open-Angle Glaucomas<br/>3 Trabectome-Mediated Ab Interno Trabeculectomy for Secondary Glaucoma or as a Secondary Procedure<br/>4 Lens Extraction in Angle Closure Glaucoma<br/>5 Gonioscopy Assisted Transluminal Trabeculotomy (GATT) for the Treatment of Adult and Developmental Glaucomas<br/>6 Ab-Interno Subconjunctival Glaucoma Implant for Advanced Open-Angle Glaucomas<br/>7 Nonpenetrating Glaucoma Surgery<br/>8 Endoscopic Cyclophotocoagulation in the Treatment of Plateau Iris and Angle Closure Glaucomas<br/>9 Ex-PRESS Miniature Glaucoma Shunt for the Treatment of Uveitic Glaucomas<br/>10 Surgical Management of Normal Tension Glaucoma<br/>11 Glaucoma Drainage Implant Surgery Combined with Pars Plana Vitrectomy and KPro Implantation<br/>12 The Modified Schocket Procedure<br/>13 Ab-interno Bleb Needling<br/>14 Drainage of Choroidal Effusions<br/>15 Surgical Management of Malignant Glaucoma<br/>Supplemental Video Table of Contents<br/>1. Video 3.1. Trabectome Procedure with Goniosynechiolysis<br/>2.Video 5.1. Gonioscopy Assisted Transluminal Trabeculotomy (GATT)<br/>3.Video 6.1. Xen Gel implantation<br/>4. Video 7.1. Non-Penetrating Glaucoma Surgery<br/>5. Video 9.1. Ex-Press Shunt Implantation<br/>6. Video 10.1. Trabeculectomy with adjunctive Mitomycin-C<br/>7. Video 11.1. Glaucoma Drainage Implant Surgery Combined with Pars Plana Vitrectomy and KPro Implantation<br/>8. Video 12.1. Modified Schocket Procedure<br/>9. Video 13.1. Ab-Interno Trabeculectomy Revision<br/>10. Video 15.1. .

::Contents##<br/>Chapter 1. Migraine and Headache: General<br/>Chapter 2. Refractory(Difficult to Treat) Headache<br/>Chapter 3. Child and Adolescent Headaches<br/>Chapter 4. Cluster Headache. Chapter 5. Psychological Comorbidities<br/>Chapter 6. Case Studies<br/>Chapter 7. Miscellaneous.

::Summary## "This textbook is a tool that is used to help students learn advanced health assessment techniques that focus on the assessment and diagnosis of common disorders of the systems of the body. Most Medical Schools, Physician Assistant School and Schools of Nursing have Advanced Practice curriculums which require an Advanced Health Assessment Course. Most courses are designed to provide students and young practitioners with a glimpse into the minds of experienced clinicians who are assessing and solving therapeutic problems on a daily basis. These students and new practitioners play a vital role in the health assessment of the public. They must know that the focus of the assessment is intense and complete and that the appropriate diagnostic intervention is selected based on solid evidence/clues from the health assessment, which will ensure that the right intervention is ordered for the right patient at the right time with due consideration of costs. It also ensures that the patient knows how, why and when to use the prescribed intervention. This textbook has met this benchmark and will continue to do so with a current edition"-- Provided by publisher.<br/>::Contents##<br/>Interviewing and history taking strategies<br/>Physical examination strategies<br/>Documentation strategies<br/>Cultural and spiritual assessment<br/>Nutritional assessment<br/>Mental health disorders<br/>Integumentary disorders<br/>Eye disorders<br/>Ear disorders<br/>Nose, sinus, mouth, and throat disorders<br/>Respiratory disorders<br/>Cardiovascular disorders<br/>Endocrine disorders<br/>Gastrointestinal disorders<br/>Neurological disorders<br/>Male genitourinary disorders<br/>Female genitourinary and breast disorders<br/>Musculoskeletal disorders.

::Summary## "Advanced Healthcare Nanomaterials summarises the current status of knowledge in the fields of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, up and coming bio-engineering devices"-- Provided by publisher.<br/>::Contents##<br/>Functional therapeutics<br/>Point-of-care diagnostics<br/>Translational materials<br/>Emerging bio-engineering devices.

::Summary## This book describes how to monitor and optimize cardiovascular dynamics using advanced hemodynamic monitoring in perioperative and intensive care medicine. The book outlines basic skills of hemodynamic monitoring, different techniques including invasive, minimally invasive, and non-invasive methods, and algorithms and treatment strategies for perioperative goal-directed hemodynamic therapy in different groups of surgical patients. Thus, the book reflects current diagnostic and therapeutic approaches in perioperative and intensive care medicine. All sections of this book have a learning-oriented style and are illustrated with tables and figures summarizing the main content. The volume is addressed both to specialists and residents using advanced hemodynamic monitoring; it reflects indications and limitations of current monitoring tools and discuss therapeutic strategies. It also helps readers to integrate new knowledge on monitoring of cardiovascular dynamics into clinical practice.<br/>::Contents##<br/>Preface<br/>Introduction<br/>Section I. Measurement of pressures<br/>Pressure physiological background<br/>Systemic arterial pressure<br/>Central venous pressure<br/>Pulmonary pressures<br/>Section II. Measurement of cardiac output<br/>Cardiac output physiological background<br/>Pulmonary artery thermodilution<br/>Transpulmonary thermodilution<br/>Pulse wave analysis<br/>Doppler techniques<br/>Echocardiography<br/>Bioimpedance and bioreactance<br/>Section III. Monitoring of volumetric parameters<br/>Volumetric parameters physiological background<br/>Global end-diastolic volume<br/>Extravascular lung water<br/>Section IV. Assessment of fluid responsiveness and dynamic tests<br/>Fluid responsiveness and dynamic tests physiological background<br/>Dynamic variables<br/>Dynamic tests<br/>Section V. Monitoring of microcirculation<br/>Microcirculation physiological background<br/>Vital microscopy<br/>Other techniques<br/>Section VI. Hemodynamic monitoring and therapy in perioperative medicine<br/>Hemodynamic monitoring and optimization in cardiac surgery<br/>Hemodynamic monitoring and optimization in non-cardiac surgery<br/>Section VII. Hemodynamic monitoring and therapy in Intensive care medicine<br/>Hypovolemic shock<br/>Cardiogenic shock<br/>Distributive shock<br/>Pulmonary edema<br/>Section VIII. Future of hemodynamic monitoring and therapy<br/>New methods and sensors<br/>Closed loop hemodynamic management<br/>Artificial intelligence and predictive analytics<br/>Conclusions.

::Summary## This book is a wide-ranging guide to advanced imaging techniques and related methods with important applications in translational research or convergence science as progress is made toward a new era in integrative healthcare. Conventional and advanced microscopic imaging techniques, including both non-fluorescent (i.e., label-free) and fluorescent methods, have to date provided researchers with specific and quantitative information about molecules, cells, and tissues. Now, however, the different imaging techniques can be correlated with each other and multimodal methods developed to simultaneously obtain diverse and complementary information. In addition, the latest advanced imaging techniques can be integrated with non-imaging techniques such as mass spectroscopic methods, genome editing, organic/inorganic probe synthesis, nanomedicine, and drug discovery. The book will be of high value for researchers in the biological and biomedical sciences or convergence science who need to use these multidisciplinary and integrated techniques or are involved in developing new analytical methods focused on convergence science. .<br/>::Contents##<br/>1.Confocal laser scanning microscopy and fluorescence correlation methods for evaluation of molecular interactions<br/>2.Number and Brightness Imaging: visualization of protein oligomerization state in living cell<br/>3.Single-molecule analysis on the coupling of molecular state and reaction kinetics<br/>4.Imaging lipid rafts in the plasma membrane using novel probe and super-resolution microscopy<br/>5.Multiplex Immunohistochemistry (IHC)<br/>6.Micro-endoscopy for live small animal fluorescent imaging<br/>7.Immuno-gold techniques<br/>8.Correlative Light and Electron Microscopy for Nanoparticle-Cell Interaction<br/>9.Diagnostic and Therapeutic Nanomedicine<br/>10.Semiconductor nanocrystals for biological imaging and fluorescence spectroscopy<br/>11.DNA/RNA fluorescence imaging by synthetic nucleic acids<br/>Section II: Label-free techniques and advanced tomographic imaging<br/>12. Magnetic resonance imaging for preclinical study<br/>13.Holotomography techniques for 3D label-free imaging of live cells and tissues<br/>14.Dynamic-contrast optical imaging techniques<br/>15.Emerging biological and clinical applications of photoacoustic tomography<br/>Section III: Potential (synergic) biotechnologies to be joined with imaging techniques<br/>16.Generation of genetically-engineered mouse models using CRISPR-Cas system<br/>17.Highly efficient generation of cell lines stably expressing genes of interest via Cre recombinase mediated knock-in method in mouse embryonic stem (ES) cells and its application for microscopic imaging techniques<br/>18.Mass spectrometry based metabolomics in translational research<br/>19.Application of mass spectrometry in drug metabolism and pharmacokinetics for drug development<br/>20.Discovery and Application of Chemical Probes for Translational Research<br/>21.Regeneration of skin cells by mesenchymal stem cell-derived exosomes.

::Contents##<br/>Test equipment in biology laboratories<br/>Automation software (acquisition, control and analysis concepts)<br/>Digital Image Processing (F. Sacerdoti)<br/>Statistic Analysis.-€ Cell identification<br/>Cell classification & Counting.-€ Cell aggregation<br/>Skin and body analysis (F. Melchi & F.M. Sacerdoti)<br/>Space or Space Simulation equipments<br/>Off-the-shelf Analysis Software. Commercial & Open Source<br/>Commercial Test Equipment<br/>Best practices.

::Contents##<br/>Laser Fundamental Principles / Georgios E Romanos<br/>Lasers and Wound Healing / Georgios E Romanos<br/>Lasers in Oral Surgery / Georgios E Romanos<br/>Lasers and Bone Surgery / Georgios E Romanos<br/>Lasers in Periodontology / Georgios E Romanos<br/>Lasers and Implants / Georgios E Romanos<br/>Photodynamic Therapy in Periodontal and Peri-Implant Treatment / Anton Sculean, Georgios E Romanos<br/>Understanding Laser Safety in Dentistry / Vangie Dennis, Patti Owens, Georgios E Romanos<br/>Appendix A: Suggested Reading<br/>Appendix B<br/>Index.

::Contents##<br/>Advanced LC-MS applications in bioanalysis / Long Yuan, Annik Bergeron, Jean-Nicholas Mess, Dafang Zhong & Qin C. Ji<br/>Method development strategies in bioanalysis / Shefali R. Patel & Naidong Weng<br/>High-throughput methods for LC-MS bioanalysis / Xianmei Cai & Wilson Shou<br/>Phospholipids-based matrix effect elimination techniques / Vincenzo Pucci<br/>Advanced sample preparation techniques prior to LC-MS / Yong Q. Tang<br/>Complex sample types / Bernd A. Bruenner, Mary C. Wells & Christopher A. James<br/>Advanced separation methods / Roger N. Hayes<br/>Multidimensional separation methods / Graeme T. Clark<br/>Computational approaches in developing accelerated chiral liquid chromatography techniques for mass spectral assays Min Meng, Laixin Wang & Scott Reuschel<br/>Novel MS detection methods / Pan Deng & Dafang Zhong<br/>Novel calibration approaches for LC-MS bioanalysis / Aimin Tan, Kayode Awaiye & Fethi Trabelsi<br/>Liquid chromatography mass spectrometry quantitative bioanalysis of proteins / Long Yuan, Annik Bergeron, Jean-Nicholas Mess, Fabio Garofolo, Anne-Françoise Aubry & Qin C. Ji<br/>Dried blood spots and their role in bioanalysis / John S. Williams & Christopher L. Brummel<br/>Analytical approaches to support microdose studies in drug discovery and development / Jim X. Shen, Yue Zhao & Xiaohui (Sophia) Xu.

::Summary## Since the publication of the first edition of Urethral Reconstructive Surgery, important refinements have been added to the urologic surgical armamentarium. Extensively revised and updated, Advanced Male Urethral and Genital Reconstructive Surgery, Second Edition guides urologists in a practical manner on how to evaluate and manage complex urethral and male genital reconstructive challenges. Chapters have been added on wound healing, synchronous urethral strictures, non-transecting anastomotic urethroplasty (including muscle and vessel sparing), overlapping buccal grafts, male urethral slings, genital skin grafting, Peyronies surgery, priapism, pediatric strictures, and prosthetics. Such chapters greatly strengthen the overall appeal of the book. The volume closes with a new comprehensive appendix of preferred instruments. With broad contributions by international authorities in reconstructiveurologic surgery, Advanced Male Urethral and Genital Reconstructive Surgery, Second Edition is a valuable resource for all urologists, from residents to reconstructive surgeons.<br/>::Contents##<br/>1. Decision Making and Surgical Technique in Urethroplasty / Steven B. Brandes<br/>2. Male Urethra and External Genitalia Anatomy / Peter A. Humphrey<br/>3. Vascular Anatomy of Genital Skin and the Urethra: Implications for Urethral Reconstruction / Steven B. Brandes<br/>4. Lichen Sclerosus / Ramon Virasoro and Gerald H. Jordan<br/>5. Imaging of the Male Urethra / Nirvikar Dahiya, Christine O. Menias, and Cary L. Siegel<br/>6. Practical Plastic Surgery: Techniques for the Reconstructive Urologist / Hema J. Thakar and Daniel D. Dugi III<br/>7. The Epidemiology, Clinical Presentation, and Economic Burden of Urethral Stricture / Keith Rourke<br/>8. Etiology, Histology, and Classification of Urethral Stricture Disease / Sean Elliot and Steven B. Brandes<br/>9. Urethrotomy and Other Minimally Invasive Interventions for Urethral Stricture / Chris F. Heyns<br/>10. Endourethral Prostheses for Urethral Stricture / Daniel Yachia and Zeljko Markovic<br/>11. Fossa Navicularis and Meatal Reconstruction / Noel A. Armenakas<br/>12. Stricture Excision and Primary Anastomosis for Anterior Urethral Strictures / Reynaldo G. Gomez<br/>13. Oral Mucosal Graft Urethroplasty / Guido Barbagli and Salvadore Sansalome<br/>14. Lingual Grafts / Alchiede Simonato and Andrea Gregori<br/>15. The Augmented Anastomotic Urethroplasty / Michael L. Guralnick and R. Corey O'Connor<br/>16. Penile Skin Flaps for Urethral Reconstruction / Benjamin N. Breyer and Jack W. McAninch<br/>17. Panurethral Strictures / Carlos Guidice<br/>18. The Application of Muscular, Myocutaneous, and Fasclocutaneous Flaps as Adjuncts in Complex Refractory Urethral Disorders / Leonard N. Zinman and Jill C. Buckley<br/>19. Posterior Urethral Strictures / A.R. Mundy and Daniela E. Andrich<br/>20. Staged Urethroplasty / Chris McClung and Hunter Wessells<br/>21. Complications of Urethroplasty / Ofer Shenfeld<br/>22. Postprostatectomy Strictures / Margit Fisch, Daniel Pfalzgraf, and C. Phillip Reiss<br/>23. Radiotherapy-Induced Urethral Strictures / Steven B. Brandes<br/>24. Complex Urinary Fistulas of the Posterior Urethra and Bladder / Steven B. Brandes<br/>25. Reconstruction of Failed Urethroplasty / Steven J. Hudak and Allen F. Morey<br/>26. Urethral Stent Complications and Methods for Explantation / Jill C. Buckley<br/>27. Reoperative Hypospadias Surgery and Management of Complications / Douglas E. Coplen<br/>28. Follow-Up Strategies After Urethral Stricture Treatment / Chris F. Heyns<br/>29. Urethral Rest as Precursor for Urethroplasty / Steven J. Hudak and Allen F. Morey<br/>30. The Use of Patient-Reported Outcome Measures in Men with Urethral Stricture Disease / Lee C. Zhao and Christopher M. Gonzalez<br/>31. Reconstruction of Synchronous Urethral Strictures / Steven J. Hudak and Allen F. Morey<br/>32. Perineal Urethrostomy / Andrew C. Peterson<br/>33. Double Overlapping Buccal Grafts / Enzo Palminteri and Elisa Berdondini<br/>34. Muscle-, Nerve-, and Vascular-Sparing Techniques in Anterior Urethroplasty / Sanjay B. Kulkarni and Pankaj M. Joshi<br/>35. Primary and Secondary Reconstruction of the Neophallus Urethra / Miroslav L. Djordjevic<br/>36. Tissue Engineering of the Urethra: The Basics, Current Concept, and the Future / Ryan P. Terlecki and Anthony Atala<br/>37. Pediatric Urethral Strictures / Michael H. Johnson, Steven B. Brandes, and Douglas E. Coplen<br/>38. Non-transecting Bulbar Urethroplasty / A.R. Mundy and Daniela E. Andrich<br/>39. Genital Skin Loss and Scrotal Reconstruction / Daniel Rosenstein<br/>40. Surgery for Priapism / Arthur L. Burnett and Ifeanyichuku Anusionwu<br/>41. Penile Skin Grafting and Resurfacing of the Glans / Giulio Garaffa, Salvatore Sansalome, and David John Ralph<br/>42. Peyronie's Disease Reconstruction: Simple and Complex / Laurence A. Levine and Stephen M. Larsen<br/>43. The Buried Penis in Adults / Richard A. Santucci and Mang L. Chen<br/>44. Penile Fracture / Jack H. Mydlo and Leo R. Doumaniao<br/>45. Vascular Surgery for Erectile Dysfunction / Jacqueline D. Villalta and Tom F. Lue<br/>46. Penile and Inguinal Reconstruction and Tissue Preservation for Penile Cancer / Steven B. Brandes and Jairam R. Eswara<br/>47. New Advances in Penile Implant Surgery / Steven K. Wilson and John D. Terrell<br/>48. Artificial Urinary Sphincters: Reoperative Techniques and Management of Complications / Landon Trost and Daniel S. Elliott<br/>49. Reconstruction and Salvage of Failed Male Urethral Slings / Jack M. Zuckerman and Kurt McCammon<br/>50. Post-prostatectomy Incontinence (Evaluation and Practical Urodynamics) / H. Henry Lai and Timothy B. Boone.

::Contents##<br/>Physiology and function of the gastrointestinal and hepatobiliary tract<br/>Dietary components relevant to gastrointestinal health<br/>Gastrointestinal disorders<br/>Hepatobiliary disorders.