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  • Book
    Yoshio Terada, Takashi Wada, Kent Doi, editors.
    Summary: This book presents up-to-date information on the clinical-pathophysiological features of acute renal injury and discusses the KDIGO diagnostic criteria, as well as novel experimental findings, including in the area of regenerative medicine. It also highlights the clinical-pathophysiological importance of AKI in clinical settings, including differential diagnoses and management of AKI. In the past, the pathology associated with sudden renal impairment was characterized as acute renal failure (ARF). However, in the 2000s, the joint efforts of specialists in fields including nephrology, intensive care medicine, and cardiovascular medicine led to the introduction of a novel concept known as acute kidney injury (AKI). As medical care progressed, patients such as high-risk elderly subjects who were not deemed to be candidates for invasive therapy came to be treated in intensive care units (ICUs). As a result, kidney injury as a subset of multiple organ failure was re-considered as AKI, especially in intensive care medicine. AKI was then proposed as a novel disease concept to emphasize the importance of early diagnosis and early intervention to improve prognosis. Presenting novel features, such as the definition of AKI, risk factors and management; biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL) and L-type fatty acid-binding protein (L-FABP); long-term outcomes of AKI; as well as renal regeneration using iPS cell, manipulation of embryonic genes, and Xenotransplanted embryonic kidney, this book is of interest to all physicians and researchers in this field around the globe.

    Part 1 Diagnosis and risk factors of AKI
    Definition and epidemiology of AKI
    Cause of AKI (prerenal, renal, postrenal)
    Pathophysiology of AKI
    Diagnosis of AKI (clinical assessment, novel biomarkers)
    Risk factors for AKI development in surgery
    Risk factors for AKI development in heart failure
    7. Contrast-induced AKI
    8. Antibiotics- and immunosuppression-related AKI
    9. AKI in setting of cancer
    Community-acquired AKI and hospital-acquired AKI
    Part 2 Complication of AKI
    11. Complication of homeostasis (mineral and acid-base)
    12. Volume overload and cardiac and pulmonary complication
    Part 3 Prevention and management of AKI
    Prerenal and renal AKI
    Postrenal AKI
    AKI in intensive care medicine
    Nondialytic supportive management of AKI
    Renal replacement therapy in AKI
    Outcomes and long-term follow-up of AKI patients
    Prevention and management of pediatric AKI
    Part 4 Experimental novel findings
    AKI-to-CKD transition
    AKI and nerve system
    AKI and immune system
    AKI and cytokines
    Part 5 AKI and regenerative medicine
    iPS cell and renal regenerative medicine
    Embryonic genes and renal regenerative medicine
    Xenotransplanted embryonic kidney.
    Digital Access Springer 2020