Books

Anatomy and cellular functions of the liver -- Bile acids and bile flow : new functions of old molecules -- Intestinal microbiome and the liver -- The liver as an immune organ -- The liver's response to injury : inflammation and fibrosis -- Stem cells and hepatocyte transplantation -- Approach to jaundice and abnormal liver function test results -- Noninvasive assessment of disease progression -- Molecular and genetics-based diagnostics -- Imaging in assessment of liver disease and lesions -- Evaluation of the hepatic mass -- Assessment of liver histology -- Critical care management of patients with liver disease -- Neurologic consequences of liver disease -- Ascites and hyponatremia -- Portal hypertension related to bleeding -- Renal failure in cirrhosis -- Cardiopulmonary complications of cirrhosis -- The hemostatic and hematopoietic system in liver disease -- Acute liver failure -- Acute-on-chronic liver failure -- Epidemiology and pathogenesis of alcoholic liver disease -- Natural history and cofactors of alcoholic liver disease -- Prevention and management of alcoholic liver disease -- Pathogenesis of nonalcoholic fatty liver disease -- Epidemiology, natural history, and evaluation of nonalcoholic fatty liver disease -- Management of nonalcoholic fatty liver disease and metabolic syndrome -- Virology and pathogenesis of hepatitis C -- Epidemiology, natural history, and diagnosis of hepatitis C -- Treatment of hepatitis C -- Virology and pathogenesis of hepatitis B -- Epidemiology, diagnosis, and natural history of hepatitis B -- Treatment of hepatitis B -- Hepatitis D -- Hepatitis A -- Hepatitis E -- HIV and the liver -- Liver disease associated with systemic viral infection -- Parasitic liver disease -- Bacterial and miscellaneous infections of the liver -- Autoimmune hepatitis -- Primary biliary cholangitis -- Primary and secondary sclerosing cholangitis -- Budd-Chiari syndrome and sinusoidal obstruction syndrome -- Portal and splenic vein thrombosis -- Hepatocellular carcinoma -- Cholangiocarcinoma -- Other malignant hepatic tumors -- Benign liver tumors -- Pretransplant evaluation and care -- Transplantation of the liver -- Post--liver transplant management -- Recurrent primary disease after liver transplantation -- The liver in pregnancy -- Nutrition and the liver -- Drug-induced liver injury -- Preoperative and postoperative hepatic dysfunctions -- Bilirubin metabolism and its disorders -- Wilson disease -- Hemochromatosis -- Α1 -antitrypsin deficiency -- Approach to and evaluation of metabolic liver diseases -- Pediatric cholestatic syndromes -- Fibrocystic diseases of the liver -- Viral hepatitis in children.

This book offers a comprehensive overview of toxicology, highlighting the significance of peptide-based toxins from marine environments. It discusses the principles of protein-carbohydrate and domain-domain interactions to increase our understanding of toxicology in zebrafish models, as well as drug interaction mechanisms and target definition in drug discovery. It also reviews the structure of marine peptides/toxins and the toxicology of peptide secreting cells and cells that respond to these enzymes, and describes the normal and abnormal toxicology of marine peptides in zebrafish models. Offering insights into the field of proteomics, particularly current practice and research models for solving its many riddles, the book also explains the analytical principles of marine protein-protein and protein-carbohydrate interaction in the context of teratogenicity in target identification in peptide- based drug discovery. Lastly, the book methodically examines the preclinical research on marine proteins/peptides.

Embryonic Cell Culture in Zebrafish / C.A. Ciarlo, L.I. Zon -- Cellular Dissection of Zebrafish Hematopoiesis / D.L. Stachura, D. Traver -- Second Harmonic Generation Microscopy in Zebrafish / D.C. LeBert, J.M. Squirell, A. Huttenlocher, K.W. Eliceiri -- Imaging Blood Vessels and Lymphatic Vessels in the Zebrafish / H.M. Jung, S. Isogai, M. Kamei, D. Castranova, A.V. Gore, B.M. Weinstein -- An Eye on Light-sheet Microscopy / D. Kromm, T. Thumberger, J. Wittbrodt -- Single Neuron Morphology In Vivo with Confined Primed Conversion / M.A. Mohr, P. Pantazis -- Visualizing Retinoic Acid Morphogen Gradients / T.F. Schilling, J. Sosnik, Q. Nie -- Using Fluorescent Lipids in Live Zebrafish Larvae: from Imaging Whole Animal Physiology to Subcellular Lipid Trafficking / J.L. Anderson, J.D. Carten, S.A. Farber -- Analysis of Cilia Structure and Function in Zebrafish / E. Leventea, K. Hazime, C. Zhao, J. Malicki -- Functional Calcium Imaging in Zebrafish Lateral-line Hair Cells / Q.X. Zhang, X.J. He, H.C. Wong, K.S. Kindt -- Physiological Recordings from the Zebrafish Lateral Line / J. Olt, A.J. Ordoobadi, W. Marcotti, J.G. Trapani.

Methods to Study Maternal Regulations of Germ Cell Specification in Zebrafish -- Patterning, Morphogenesis, and Neurogenesis of Zebrafish Cranial Sensory Placodes -- Oligodendrocyte Differentiation -- Studying the Peripheral Sympathetic Nervous System and Neuroblastoma in Zebrafish -- Zebrafish As a Model for Understanding Enteric Nervous System Interactions in the Developing Intestional Tract -- Methods to Study the Development, Anatomy, and Function of the Zebrafish Inner Ear Across the Life Course -- Imaging Collective Cell Migration and Hair Cell Regeneration in the Sensory Lateral Line -- Analysis of the Retina in the Zebrafish Model -- Strategies for Analyzing Cardiac Phenotypes in the Zebrafish Embryo -- Chemical Approaches to Angiogenesis in Development and Regeneration -- Quantitative Methods for Studying Hemostasis in Zebrafish Larvae -- Zebrafish Kidney Development -- Zebrafish Pancreas As a Model for Development and Disease -- Endoderm Specification and Liver Development -- Emerging Tools to Study Proteoglycan Function During Skeletal Development -- Generation and Analysis of Zebrafish Melanoma Models -- Learning and Memory in Zebrafish (Danio rerio) -- Working With Zebrafish at Postembryonic Stages.Methods to Study Maternal Regulations of Germ Cell Specification in Zebrafish -- Patterning, Morphogenesis, and Neurogenesis of Zebrafish Cranial Sensory Placodes -- Oligodendrocyte Differentiation -- Studying the Peripheral Sympathetic Nervous System and Neuroblastoma in Zebrafish -- Zebrafish As a Model for Understanding Enteric Nervous System Interactions in the Developing Intestional Tract -- Methods to Study the Development, Anatomy, and Function of the Zebrafish Inner Ear Across the Life Course -- Imaging Collective Cell Migration and Hair Cell Regeneration in the Sensory Lateral Line -- Analysis of the Retina in the Zebrafish Model -- Strategies for Analyzing Cardiac Phenotypes in the Zebrafish Embryo -- Chemical Approaches to Angiogenesis in Development and Regeneration -- Quantitative Methods for Studying Hemostasis in Zebrafish Larvae -- Zebrafish Kidney Development -- Zebrafish Pancreas As a Model for Development and Disease -- Endoderm Specification and Liver Development -- Emerging Tools to Study Proteoglycan Function During Skeletal Development -- Generation and Analysis of Zebrafish Melanoma Models -- Learning and Memory in Zebrafish (Danio rerio) -- Working With Zebrafish at Postembryonic Stages.

This book provides cutting-edge studies and technologies using small fishes, including zebrafish, medaka, and other fishes as new model animals for molecular biology, developmental biology, and medicine. It also introduces eccentric fish models that are pioneering new frontiers of biology. Zebrafish and medaka have been developed as lower vertebrate model organisms because these small fish are easy to raise in the laboratory and are useful for the live imaging of the morphology and activity of cells and tissues in intact animals. By virtue of those specific advantages, fish studies have demonstrated the common features of vertebrates and raised further questions toward understanding the mystery of life. The book consists of four parts: "Development and Cell Biology", "Homeostasis and Reproduction", "Clinical Models", and "Eccentric Fish". Together they describes the core area of small fish study - often considered mere zoology but which is actually proving to be the universal basis of life. Written by leading scientists, the book helps readers to understand small fishes, inspires scientists to utilize small fishes in their studies, and encourages anyone who wants to participate in the large and fantastic world of small fish.

This book introduces zero-effort technologies (ZETs), an emerging class of technologies that require little or no effort from the people who use them. ZETs use advanced computing techniques, such as computer vision, sensor fusion, decision-making and planning, machine learning, and the Internet of Things to autonomously perform the collection, analysis, and application of data about the user and/or his/her context. This book begins with an overview of ZETs, then presents concepts related to their development, including pervasive intelligent technologies and environments, design principles, and considerations regarding use. The book discusses select examples of the latest in ZET development before concluding with thoughts regarding future directions of the field.

Zic family in animal evolution and development. comparative genomics of the Zic family genes / Jun Aruga, Minoru Hatayama -- Cnidarian Zic genes / Michael J. Layden -- Odd-paired: the Drosophila Zic gene / Deborah A. Hursh, Brian G. Stultz -- Zic genes in nematodes: a role in nervous system development and Wnt signaling / Guillaume Bordet, Vincent Bertrand -- Lophotrochozoan Zic genes / Jun Aruga -- Ascidian Zic genes / Yutaka Satou, Kaoru S. Imai -- Amphibian Zic genes / Christa Merzdorf, Jennifer Forecki -- Zic genes in teleosts: their roles in dorsoventral patterning in the somite / Kota Abe, Toru Kawanishi, Hiroyuki Takeda -- Zebrafish Zic genes mediate developmental signaling / Cecilia Lanny Winata, Vladimir Korzh -- Overview of rodent Zic genes / Koula E. M. Diamand, Kristen S. Barratt, Ruth M. Arkell -- Rodent Zic genes in neural network wiring / Eloísa Herrera -- Zic family in medicine. Zic family proteins in emerging biomedical studies / Jun Aruga -- ZIC1 function in normal cerebellar development and human developmental pathology / Jun Aruga, Kathleen J. Millen -- ZIC2 in holoprosencephaly / Kristen S. Barratt, Ruth M. Arkell -- ZIC3 in Heterotaxy / Helen M. Bellchambers, Stephanie M. Ware -- Deregulation of ZIC family members in oncogenesis / Rob Houtmeyers, Jabob Souopgui, Sabine Tejpar -- Roles of ZIC2 in regulation of pluripotent stem cells / Hisato Kondoh -- Zic family in medicine / Role of Zic family proteins in transcriptional regulation and chromatin remodeling / Minoru Hatayama, Jun Aruga.

"Compiles the most current information on the Zika virus and its associated diseases This comprehensive book provides the most up-to-date information for students, medical students, and scientists on Zika virus and its associated diseases. It includes all the information related to the Zika virus since its discovery in 1947; its epidemic outbreak in 2007-2014; how the epidemiology changed in America in 2015-2016; its mode of transmission; how to prevent and treat it; and associated diseases. Zika Virus and Diseases: From Molecular Biology to Epidemiology offers complete and up-to-date coverage in 10 chapters. It presents information from papers that attempted to associate the virus with diseases in Africa until the first animal experiment; discusses its association with Guillain-Barre syndrome and microcephaly; describes the basic mechanisms for Zika (ZIKV) replication, including important differences between Dengue (DENV), West-Nile virus (WNV), and ZIKV; explains the difference between the strains and discusses the pathogenesis of them; covers the papers that showed all the interferences that Zika can cause, and the pathways which can be modified; and more. The first book since 1947 to put together all the scientific information Compiles all the information received in the last year about Zika virus Clearly demonstrates the origin and discovery of the virus Zika Virus and Diseases: From Molecular Biology to Epidemiology will appeal to graduate students, medical students, basic researchers, clinicians in infectious disease, microbiology, and virology, as well as people in related disciplines interested in learning more about this topic"--Provided by publisher.

This book, now in an extensively revised second edition, describes the crucial role of zinc signaling in biological processes on a molecular and physiological basis. Global leaders in the field review the latest knowledge, including the very significant advances in understanding that have been achieved since publication of the first edition. Detailed information is provided on all the essentials of zinc signaling, covering molecular aspects and the roles of zinc transporters, the zinc sensing receptor, and metallothioneins. Detection techniques for zinc signals, involving genetically encoded and chemical probes, are also described. The critical contributions of the zinc signal in maintaining health and the adverse consequences of any imbalance in the signal are then thoroughly addressed. Here, readers will find up-to-date information on the significance of the zinc signal in a wide range of conditions, including cardiovascular disorders, neurodegenerative diseases, diabetes, autoimmune diseases, inflammatory conditions, skin disease, osteoarthritis, and cancer. The book will be of value for researchers, clinicians, and advanced students.

1. T. Zirkulationsorgane, Mediastinum, Zwerchfell, obere Luftwege -- 2. T. Trachae. Bronchien. Lungen. Pleura.

Genetic disorders and dysmorphic conditions -- Neonatology -- Developmental/behavioral pediatrics -- Allergy and immunology -- Cardiology -- Child abuse and neglect -- Rheumatology -- Dermatology -- Pediatric endocrinology -- Vascular anomalies -- Nutrition and gastroenterology -- Hematology and oncology -- Infectious diseases -- Nephrology -- Urologic disorders -- Neurology -- Pulmonary disorders -- Surgery -- Pediatric and adolescent gynecology -- Ophthalmology -- Oral disorders -- Orthopedics -- Pediatric plastic surgery -- Otolaryngology -- Fundamentals of pediatric radiology.

Since magnifying endoscopy of the stomach, or zoom gastroscopy, was first performed at the beginning of the 21st century , there have been numerous findings in the field worldwide. The author of this volume has developed a standardized magnifying endoscopy technique that enables endoscopists to constantly visualize the microanatomy (subepithelial capillaries and the epithelial structure) within the stomach. With this technology, it has become easy to obtain magnified endoscopic findings. Techniques differ, however, depending upon the endoscopist. Endoscopists around the world do not have a standardized magnifying endoscopy technique, which is mandatory for the scientific analysis of their findings. In addition, there is no logical explanation for how and which microanatomies are visualized by magnifying endoscopy with narrow-band imaging in the glandular epithelium of the stomach. This inconsistency results in considerable confusion among researchers and clinicians and a lack of terminology for the purposes of analysis. As magnifying endoscopy with narrow-band imaging (NBI) becomes more popular throughout the world, there is increased demand for a specialized reference book focused on this subject. The aims of the present volume, Zoom Gastroscopy: Magnifying Endoscopy in the Stomach, are manifold: (1) to illustrate the standard magnifying endoscopic technique that can visualize subepithelial mucosal microvessels as small as capillaries, the smallest unit of blood vessels in the human body, (2) to explain the optical phenomena and principles for NBI and its application to magnifying endoscopy, (3) to clarify which microanatomies are visualized by magnifying endoscopy with NBI and how this is achieved, and (4) to present a diagnostic system so called VS classification system for early gastric neoplasias. With a single author, the book consistently uses uniform anatomical terms to describe endoscopic findings, providing an essential reference for endoscopists in the world.

Today, more than 200 diseases occuring in humans and animals are known to be mutually transmitted. Classic infectious disease such as rabies, plague, and yellow fever have not been eradicated despite major efforts. New zoonotic diseases are appearing due to global conditions such as overpopulation, wars, and food scarcity, which facilitate human contact with rodents, stray animals, and their parasites. In addition, humans are unwittingly becoming accidental hosts and new links in an infectious chain by engaging in activities such as survival training, which involves camping in open areas, and consumption of raw or insufficiently cooked food. Zoonotic infections cause a variety of symptoms that often do not provide clear evidence of a known disease. Zoonoses, Fourth Edition, describes most occurring worldwide zoonoses and facilitates the identification, diagnosis, and treatment of zoonotic infections. Written by a team of doctors, medical microbiologists, and veterinarians, this revised and updated edition - translated from the noted German reference Zoonosen - covers all aspects of the epidemiology and prevention of zoonotic diseases supported by clear descriptions of various illnesses. Specifically, this fourth edition covers zoonoses caused by viruses, bacteria, fungi, and parasites; infections caused by animal bites; infections and intoxications by animal foods; iatrogenic transmission of zoonotic pathogens. Zoonoses is an indispensable reference for both clinicians and laboratorians. -- from back cover.

"Pediatricians are often the first line of defense for children with developmental and behavioral issues, and are often responsible for initial screening. This practical guide is geared toward primary care physicians to help them quickly identify issues and decide on next-steps. Chapters are in outline format, and cover a broad array of issues ranging from common childhood behavioral problems (biting, bullying, toilet training) to more critical (physical and sexual abuse, incarceration of a parent, violence). In addition, we have added more chapters addressing two generational approaches, because in our experience, the best way to help children is to help their parents and the best way to reach parents is through their children. Such chapters include parental depression, preventing unplanned pregnancy for parents of our patients, identifying and addressing social determinants of health, and parental self-understanding. We have also added new ideas to improve child health supervision for the 21st century specifically understanding and incorporating growth mindset, implicit bias, financial stress, cultural differences in parenting, and preventing unplanned pregnancy"-- Provided by publisher.

Introduction / Alexander Huber -- Establishment of otorhinolaryngology (ORL) as a specialty at the turn of the 20th century / Albert Mudry -- Felix Robert Nager and the establishment of the Zurich ORL Department in 1917 / Albert Mudry -- 100 years of life and work of the Zurich ORL Department / Andreas Heinrich Eckhard -- The Changing face of deafmutism: from disability to deafhood / Thomas Spillmann, Dorothe Veraguth -- Temporal bone laboratory: a successful source of inspiration / Christof Röösli -- Ugo Fisch and the full access to the internal auditory canal / Albert Mudry -- Cochlear implant: 40 years of research and development / Norbert Dillier, Flurin Pfiffner -- Tonsillectomy: a mythic surgery / Claudine Gysin -- Progress in head and neck surgery / Gerhard Huber, Stephan Schmid -- Phoniatrics: first traces in Zurich - development of a medical specialty dealing with communication disorders / Jörg Bohlender -- From microscopic to endoscopic sino-nasal and skull base surgery / David Holzmann, ichael Soyka -- Evolution of teaching ORL to medical students / Rudolf Probst, Peter Ott -- The Evolution of vestibular research, diagnostics and treatment at the University Hospital Zurich / Vincent G. Wettstein -- 100 years otorhinolaryngology, August 30th to September 2nd 2017 / Nicole Peter, Alexander Huber.

This book provides clinicians with state of the art information on the use of zygomatic implants to restore function and improve quality of life. International experts come together to showcase important innovations and advances in techniques that will assist in the optimization of outcomes. Readers will find information on indications, biomechanics, the role of imaging, digital treatment planning, and all aspects of implant placement. Individual chapters are devoted to different procedures, including the extramaxillary surgical technique, extended sinus lift with retained bone window, the anatomy-guided approach, the quad zygoma technique, and static and dynamic guided surgery. The use of zygomatic implants specifically in oncology patients is also given detailed consideration. Today, the zygomatic approach offers many advantages for patients with severe maxillary resorption, in whom grafting was in the past unavoidable. In providing an up-to-date global perspective on the zygoma concept, this book will be an invaluable source of guidance for practitioners at all levels of experience.