Books

Summary: "The first complete review book for all of the PA Rotation Exams! At last! A complete exam review book for the PA Rotation (EOR) exams that specifically addresses PAEA requirements! Presented in a full-color, concise format, The PA End of Rotation Exam Review covers all the information required to succeed on the EOR Exams for Internal Medicine, Family Medicine, Pediatrics, OB/GYN, Surgery, Emergency Medicine, and Psychiatry. Closely following the PAEA EOR Exam blueprint and featuring practice questions, as well as online review questions for each rotation, this practical solution gives PA students everything they need for EOR exam success. Excellent Value: ll PA rotations are covered in a single text. Focused: Content mirrors the PAEA Blueprint for EOR exams, ensuring that students learn the information they need to excel on the exam. Concise: the tabular and outline format is ideal for quick exam study. High-yield: Information and questions are geared toward each EOR exam and cover high-yield topics, ensuring strong preparation. Easy-to-use: Overlapping content between rotations is fully cross-referenced and easy to locate, regardless of the student's current rotation. Full color: High-quality artwork and photos provide must-know visual information, including dermatology images. Online resources: Practice tests--50 review questions per rotation - provide additional practice and review. Enrich Your eBook Reading Experience with Enhanced Video, Audio and Interactive Capabilities! Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech. Adapt for unique reading needs, supporting learning disabilities, visual/auditory impairments, second-language or literacy challenges, and more"--Provided by publisher.

Summary: This volume sheds new light on the marine fauna and geological setting of the Tjörnes Sequence, North Iceland, which is a classic site for the Pliocene and Pleistocene stratigraphy of the North Atlantic region. Readers will discover descriptions of new data collected by the editors over a period of over three decades on marine faunal assemblages and sedimentology available for palaeoenvironmental reconstructions, as well as the tectonic and stratigraphical relationships on Tjörnes Peninsula. The book includes a comprehensive account of all the collections of marine fossil invertebrate macrofossils and foraminifera known to the editors from the Tjörnes Sequence. It is expected to elucidate sedimentological and faunal changes from relatively stable Pliocene conditions to highly variable and periodically harsh climatic conditions of recurring Quaternary glaciations. The distribution, recent or fossil, of various species is recorded and pertinent ecological and biological features are also discussed. The Tjörnes Sequence records the Neogene migration of Pacific species into the North Atlantic. Researchers in geology, climate science, environmental science and earth science will find this book particularly valuable.

Contents:
Chapter1. A Brief Resumé of the Geology of Iceland
Chapter2. The Marine Realm Around Iceland
a Review of Biological Research
Chapter3. The Evolution of the Tjörnes Sedimentary Basin in Relation to the Tjörnes Fracture Zone and the Geological Structure of Iceland
Chapter4. A Review of the Research History of the Tjörnes Sequence, North Iceland
Chapter5. Lithostratigraphy of the Tjörnes Sequence in Barmur and Höskuldsvík on the West Coast of Tjörnes, North Iceland
Chapter6. An Age Model for the Miocene to Pleistocene Tjörnes Sequence, North Iceland
Chapter7. Systematic Overview of the Pliocene Molluscs and Barnacles of the Barmur Group on Tjörnes, North Iceland
Chapter8. Foraminifera in the Pliocene Barmur Group on Tjörnes, North Iceland
Chapter9. Reconstructing the Palaeoenvironments of the Pliocene Barmur Group in the Tjörnes Basin, North Iceland
Lithostratigraphy of the Upper Part of the Tjörnes Sequence in Furuvík, Breiðavík, Öxarfjörður, and Central Tjörnes Mountains, North Iceland
Systematic Overview of the Molluscs and Barnacles of the Quaternary Breiðavík Group, North Iceland
Chapter12. Foraminifera in the Early Pleistocene Part of the Breiðavík Group, North Iceland Knudsen
Chapter13. Reconstructing the Palaeoenvironments of the Quaternary Tjörnes Basin, North Iceland
Chapter14. Migration of Pacific Marine Mollusc Fauna into the North Atlantic Across the Arctic Ocean in Pliocene and Early Pleistocene Time.

Summary: This book is a practical, comprehensive guide to the management of children and adolescents in general dental practice. A logical, evidence-based approach to oral health is adopted throughout. The commonly encountered oral and dental problems and their diagnosis and treatment are covered in detail, with particular attention to dental caries, dental trauma, developmental anomalies, periodontal problems, and soft tissue conditions. Up-to-date guidance is provided on history taking, dental examination, preventive strategies and advanced behaviour management. In addition the relevance of common medical conditions to dental management is discussed. The book is divided into four sections, each of which focusses on a specific age group, helping the reader to relate clinical issues to the different dental developmental stages. The readily understandable text is supported by many informative colour illustrations and diagrams.

Contents:
Birth To 3 Years Old: Growth and Development in Relation to Paediatric Dentistry
Introduction to the Dental Surgery
Prevention and Interventions in Oral Health Care in Children. 3 To 6 Years Old: Behaviour Management of the Paediatric Patient for Dental Procedures
Management of Dental Caries in Primary Teeth
Dento-Alvoeolar Trauma in the Primary Dentition
Safeguarding for the Paediatric Patient. 6- 12 Years Old: Medical History and Dental Management of the Young Patient
Tooth Eruption and Common Disturbances
Dental Anomalies in the Young Permanent Teeth
Management of Dental Caries in the Young Permanent Teeth
Dento-Alvoeolar Trauma in the Permanent Dentition. 12 To 16 Years Old: Periodontal Conditions
Tooth Surface Loss
Common Soft Tissue and Hard Tissue Lesions.

Summary: Paediatric Electromyography is a single-author textbook which covers the full range of applications of the techniques of nerve conduction and electromyography (EMG) in children from the neonatal period to the late teenage years. It comprises five sections. Section 1 in its first chapter, gives a detailed introduction to the different skills that are needed to effect successful interventions in paediatric EMG. The emphasis here is that paediatric EMG is not simply adult EMG applied to younger subjects.

Contents:
Introduction
Basic physiology
Nerve physiology
Pathophysiological correlations in neuropathies
Nerve damage and entrapment syndromes
Motor unit anatomy and physiology
Needle EMG findings in different pathologies
Investigation of channelopathies
Techniques used to test the neuromuscular junction in children
Pthophysiological associations in paediatric neuromuscular junction disorders
Results of the clinical application of SPACE in suspected disorders of the neuromuscular junction
More advanced techniques.

Summary: This book introduces the clinical analysis and accompany cases of paediatric Kawasaki disease. It has 14 chapters about typical Kawasaki disease, atypical Kawasaki disease, recurrent, misdiagnosis, and complications involved different systems, such as cardiovascular, digestive, nervous, blood, respiratory, urinary, bone and joints, and endocrine systems complications. In this book, 53 Kawasaki cases are presented with clinical history, physical examination, laboratory findings, diagnosis, treatment and discussion. This book is helpful for clinicians, ultrasonologist, and radiologist to support early diagnosis and proper treatment, which can significantly improve the prognosis of Kawasaki disease.

Contents:
Cardiovascular System
Digestive System
Nervous System
Blood System
Respiratory System
Urinary System
Bone and Joint System
Endocrine System
IVIG Resistance
Kawasaki Disease Recurrence
Missed Diagnosed Cases
Atypical Kawasaki Disease Cases
Vaccination Related Case
Contraversial Cases
Cardiac Tumor.

Contents:
1. Clinical approaches
2. Neurodiagnostic tools
3. Signs and symptoms
4. Specific conditions
5. Consultation with other services
6. Emergencies
7. Pharmacopoeia.

Summary: The book presents a problem-based, rational approach to the diagnosis of orthopaedic problems in children. It is divided into five sections based on the age at which specific problems may be encountered; the newborn, the neonate and infant, the toddler and the pre-school child, the child in the school-going age and the adolescent. The authors outline a systematic approach to arrive at a tentative diagnosis by asking relevant questions related to the presenting symptom and then performing a thorough clinical examination. They then suggest the most appropriate investigations to confirm the diagnosis. Each chapter deals with the common conditions that may lead to the problem; the rarer causes of the problem are listed at the end.

Contents:
The deformed hip
The deformed femur
The deformed knee
The bowed tibia
The deformed foot
The inverted foot
The everted foot
The deformed shoulder
The deformed elbow
The deformed wrist
The deformed spine
Anomalies of fingers or toes
Absence of digits of the hands or feet
Duplication of fingers
Duplication of toes
Deformities of the fingers or toes
Limb length inequality at birth
Abnormal body proportions or dwarfism evident at birth
Decreased movement of an upper or lower limb in the neonate
Deformities of the neck and limitation of movement of the neck
The child with multiple deformities
Acquired deformities of the knee
In-toeing gait and out-toeing gait
Toe walking
The flat foot
The child with a painless limp
The delayed walker
Deformities and limitation of movements of the shoulder girdle
Deformities and limitation of motion of the forearm
Deformities and limitation of movements of the wrist
Brittle bones and frequent fractures
The child with a painful limp
The painful hip
Short stature and altered body proportions
Gigantism
Acquired limb length inequality
The painful hip in adolescence
The painful knee in adolescence
The painful foot adolescence. .

Contents:
Vulnerable Bodies and Embodied Boundaries
Rural Women?s Bodies and Invisible Hands: Neoliberalism and Population Control in China
Arrogant Perceptors, World-Travellers, and World-Backpackers: Rethinking María Lugones? Theoretical Framework through Lukas Moodysson?s Mammoth
Embodied Vulnerability in Large Scale Technical Systems
Vulnerable Dam Bodies, Water Bodies and Human Bodies
Toxic Skin and Animal Mops: Ticks and Humanimal Vulnerabilities
Mothering With Neuroscience in a Neoliberal Age: Child Disorders and Embodied Brains
Sexual Arousal, Danger and Vulnerability
The Author?s Body: Almodóvar, auteur, and the Film Object
Performativity and Expression: The Case of David Cronenberg?s M. Butterfly.

Summary: Now in its second edition Paediatric Palliative Medicine covers all aspects of the care of children with life limiting illnesses, including symptom control, the philosophy and models that support delivery of palliative medicine to children, and the practical delivery of palliative medicine to other professionals and to families.

Summary: This book provides the reader with a theoretical and practical understanding of two health care delivery models: the patient/child centred care and family-centred care. Both are fundamental to caring for children in healthcare organizations. The authors address their application in a variety of paediatric healthcare contexts, as well as the ethical and legal issues they raise. Each model is increasingly pursued as a vehicle for guiding the delivery of health care in the best interests of children. Such models of health care delivery shape health care policies, programs, facility design, resource allocation decisions and day-to-day interactions among patients, families, physicians and other health care professionals. To maximize the health and ethical benefits these models offer, there must be shared understanding of what the models entail, as well as the ethical and legal synergies and tensions they can create. This book is a valuable resource for paediatricians, nurses, trainees, graduate students, practitioners of ethics and health policy.

Summary: This book provides readers with a comprehensive evaluation of paediatric radiographs in preparation for the demanding Rapid Reporting component of the Fellowship of the Royal College of Radiologists (FRCR) Part 2B examination, where the margin between pass and fail is very narrow. While other resources may include only a handful of paediatric images in a practice reporting packet, this book is dedicated solely to improving paediatric reporting skill and knowledge. It is designed to address an important deficiency identified in the FRCR Part 2B Examiners' Report, in that "many candidates struggle with interpretation of paediatric imaging - even for common paediatric pathologies". The ten practice tests presented, each with 30 images, will assist readers not only in passing the examination but also in the real world when they have to report paediatric radiographs independently. The range of cases covered, from neonate to adolescent, delivers a sound knowledge of both common paediatric fracture patterns and patterns which are subtler but require a definitive answer as to whether they are normal or abnormal. Guidance is also provided on how to describe each abnormality.

Summary: This book aims to provide readers with updated information on the diagnosis and management of common sleep disorders in children. An overview of sleep physiology and sleep disorders evaluation followed by an in-depth discussion with illustrative case examples of the most frequent sleep disorders encountered in children. A section on sleep disorders in children with neuromuscular and developmental diseases has also been included. Written by members of the Asia Pacific Paediatric Sleep Alliance and experts from the region, this case-based textbook will be a valuable reference for sleep researchers, paediatricians, and child neurologists, as well as those who are interested in this field of medicine.

Contents:
Intro
Preface
Contents
Part I: Introduction
1: Functions and Control of Sleep
1.1 The Need to Sleep
1.2 Control of Sleep
1.2.1 Generation of Circadian Rhythm
1.2.2 Sleep and Arousal
1.2.3 The NREM and REM Sleep
1.2.3.1 NREM Circuit
1.2.3.2 REM Circuit
1.2.3.3 The Role of Hypocretin/Orexin
1.3 Functions of Sleep
1.3.1 Sleep and EEG Recovery
1.3.2 Sleep, Brain Energy Replenishment, Molecular Regeneration
1.3.3 Sleep and Toxin Removal Within the Brain
1.3.4 Sleep and Memory
1.3.5 Sleep and Immunity 1.3.6 Sleep, Mood, and Emotion
1.3.7 Sleep: The Developmental Perspective
References
2: Sleep Physiology and Architecture
2.1 Sleep Architecture
2.2 Sleep Physiology
References
3: Sleep Needs: Cross-Cultural Comparisons and Problems with Sleep Deprivation
3.1 Introduction
3.2 Sleep Duration
3.2.1 Developmental Alteration of Sleep Duration
3.2.2 Cross-Cultural Difference of Sleep Duration
3.2.3 Factors Associated with Sleep Duration
3.2.4 Problems Associated with Decreased Sleep Duration
3.3 Sleepiness
3.3.1 Sleepiness vs. Sleep Duration 3.3.2 Factors Associated with Sleepiness
3.4 Sleep Need Index (SNI)
3.5 Conclusion
References
Part II: Evaluation of Sleep Disorders
4: Clinical Assessment
4.1 Preparation
4.2 History Taking
4.2.1 Chief Complaint and Associated Symptoms
4.2.2 Sleep Patterns and Sleep-Wake Schedule
4.2.3 Treatment History, Medical History, Developmental History, and Psychiatric History
4.2.4 Family History
4.3 Physical Examination
4.3.1 Sleep-Associated Physical Examination
4.4 Questionnaire and Scale 4.4.1 Bedtime Problems, Excessive Daytime Sleepiness, Awakenings, Regularity and Snoring Screener (BEARS)
4.4.2 Children's Sleep Habit Questionnaire: Preschool and School Ages (CSHQ)
4.4.3 Sleep Disturbance Scale for Children (SDSC)
4.4.4 Pediatric Daytime Sleepiness Scale (PDSS)
4.4.5 Children's Sleep Comic
4.4.6 Sleep Diary and Sleep Log
4.4.7 Structured Interview
4.5 Laboratory Test
4.5.1 Blood Test
4.5.2 Dim Light Melatonin Onset (DLMO)
4.5.3 Cerebrospinal Fluid (CSF) Hypocretin (Orexin) Level
4.6 Imaging Test
4.6.1 Cephalometry 4.6.2 Magnetic Resonance Imaging (MRI)
4.7 Conclusions
References
5: Sleep Diagnostics
5.1 Diagnosis
5.2 Home Audio and Video Recording
5.3 Pulse Oximetry
5.3.1 Technology Behind Pulse Oximetry
5.3.2 Limitations of Pulse Oximetry
5.4 Actigraphy
5.4.1 Indications for Actigraphy
5.4.2 Limitations
5.5 Paediatric Polysomnography
5.5.1 Mechanics of Polysomnography
5.5.2 Interpretation and Scoring
5.5.3 Indications for Paediatric Polysomnography
5.5.4 Limitations of Polysomnography
5.5.5 Multiple Sleep Latency Test (MSLT)

Contents:
Evolution, child development and the thyroid : a phylogenetic and ontogenetic introduction to normal thyroid function / Krude, H.
Human fetal thyroid function / Polak, M.
The role of thyroid hormones for brain development and cognitive function / Rovet, J. F.
Neonatal screening for congenital hypothyroidism / Torresani, T.
Diagnosis, treatment and outcome of congenital hypothyroidism / Van Vliet, G.; Deladoëy, J.
Clinical genetics of congenital hypothyroidism / Szinnai, G.
Central hypothyroidism in children / Garcí́a, M., Fernssndez, A., Moreno, J.C.
Thyroid hormone cell membrane transport defect / Ramos, H.E.
Resistance to thyroid hormone / Onigata, K., Szinnai, G.
Iodine deficiency in children / Pearce, E.N.
Thyroid autoimmunity / Wiersinga, W.M.
Clinical aspects of Hashimoto's thyroiditis / Radetti, G.
Graves' disease in children / Léger, J.
Thyroid nodules and differentiated thyroid cancer / Bauer, A.J.
Medullary thyroid carcinoma in children / Viola, D., Romei, C.; Elisei, R.

Summary: This concise but comprehensive guide covers all common procedures in pain management necessary for daily practice, and includes all topics on the pain medicine curricula of the American Board of Anesthesiology, World Institute of Pain/Fellow of Interventional Pain Practice, and American Board of Pain Medicine. All nerve blocks (head, neck, back, pelvis and lower extremity) are discussed. Pain: A Review Guide is aimed at trainees in pain medicine all over the world. This book will also be beneficial to all practitioners who practice pain.

Contents:
Tation
Temperature modalities
Manipulation, mobilization, massage, traction
Casting and splinting
Exercise therapy
23. Work Rehabilitation
Importance of early intervention and early return to work in reducing absence
Psychosocial factors as the main determinants of disability
Identification of obstacles to recovery
Components of successful comprehensive rehabilitation program
Multidisciplinary approaches for those who do not return to work within a few weeks
Functional Capacity Evaluation
24. Complementary Therapies (CAM)
CAM
25. Clinical States: Taxonomy
IASP classification of chronic pain syndromes
Application and definition of pain terms
26. Pain in special population
Pain in Infants, Children, and Adolescents
Pain in older adults
Delirium in the elderly
Pain Issues in Individuals with Limited Ability to Communicate Due to Neurocognitive Impairments
27. Pain Relief in Persons with Substance use and Addictive Disorders
Biopharmacologic and neurophysiologic basis of addiction
Interactions between addiction and pain
Screening for substance use disorder or addiction in patients with pain
Principles of comprehensive approach to pain management in patients with addiction
Pharmacologic treatment of patients with addiction
Acute pain management of patients with active addiction or in recovery
Analgesic response to opioids in patients with addiction
Risks and benefits of opioid use in treatment of chronic/cancer pain in patients with substance use disorder
Needs of special populations
Legal, regulatory, reimbursement issues limiting access to care for patients with pain and addiction
Treatment of withdrawal
List of addictive drugs and their metabolites in urine
Impact of alcohol use on pain
28. Pain Relief in Areas of Deprivation and Conflict
Variability of availability and access to adequate pain treatment worldwide
Causes of pain worldwide
Spect cal principles in clinical assessment, explanation, and treatment
Common causes, diagnostic evaluation, and treatment in men
Common causes, diagnostic evaluation, and treatment in women
Superior hypogastric plexus block
Ganglion impar block
16. Surgical Pain Management
Importance of general health status in preoperative evaluation
Surgical lesioning of brain, brain stem, spinal cord, peripheral nerves
Radiofrequency treatment
Neurolysis
Spinal cord and peripheral nerve stimulation
Intrathecal drug delivery
DRG stimulator
Cordotomy
Kyphoplast and vertebroplasty
17. Nerve conditions
Complex Regional Pain Syndromes
Phantom limb pain
Peripheral neuropathy
Other nerve conditions as mononeuropathy, mononeurpathy multiplex and others
18. Central pain
Central pain
19. Cancer Pain
Palliative care
Hospice care
Comprehensive evaluation of patients with cancer pain
Principles of treatment
Analgesic ladder approach
Anesthetic approaches
Surgical and interventional radiologic approaches
Neurostimulatory approach
Physical therapy
Psychological approaches
Needs of special populations
Benefit to burden ratio
Anorexia and cachexia associated with cancer
20. Pain in Pregnancy and Labor
Factors influencing the perception of pain in pregnancy compared with the non-pregnant state
Causes of pain and principles of pain management in pregnancy
Mechanisms, characteristic, benefits, consequences and management of labor pain
21. Acute Pain
Epidemiology of inadequate control
Physiologic and psychologic effects
Pharmacologic properties of major classes of drugs used for acute pain management
Comprehensive plan for optimal perioperative pain management
Non-pharmacologic treatment
Clinical outcomes to be evaluated
Tools for assessment and measurement
Role of patient and family education
Treatment of nonsurgical pain
22. Physical Medicine and Rehabili.

Summary: This book focuses on the reciprocal interactions between pain, emotion and cognition. International experts report on their findings, clinical experience and the most recent literature on the complex relations between these three domains. Clinical, psychological, behavioral and neuroimaging approaches converge towards aiding patients suffering from pain, cognitive impairment or emotional distress. Beyond the pathophysiological aspects of pain, difficulties encountered with patients are analyzed and strategies are proposed to optimize treatment, doctor-patient relationships, and patient well-being. This work will appeal to a broad readership, from clinical medical practitioners to psychologists, nurses and pain specialists.

Contents:
Part I Nociception, Pain, Emotion and Cognition Interconnections
Cognitive Psychology and Neuropsychology of Nociception and Pain
Emotional Aspects of Chronic Pain
Cerebral and Spinal Modulation of Pain by Emotions and Attention
Understanding the Suffering of Others: The Sources and Consequences of Third-person Pain
Neuroplasticity in the Pain, Emotion and Cognition Nexus
Part II Measurement Issues
Tools that Should be Considered in Pain Assessment: Cognitive Factors, Emotion and Personality
Pain Evaluation in Patients with Cognitive Impairment
Behavioural/Facial Markers of Pain, Emotion, Cognition
Part III Management Issues
Pharmacological Pain Management: For Better or for Worse?
Psychological Approaches to the Management of Pain, Cognition and Emotion
Physical Therapy and Exercise: Impacts on Pain, Mood, Cognition, and Function
Part IV Special Populations
Phantom Pain: The Role of Maladaptive Plasticity, Emotional and Cognitive Variables
Pain in Parkinson Patients
Clinical Pain in Schizophrenia, a Forgotten Area
The Pain, Emotion and Cognition Nexus in Older Persons and in Dementia.

Summary: "Covering the newest trends and treatments in pain care, as well as the pain treatment strategies that have been successfully employed in the past, Pain Care Essentials and Innovations brings you fully up to date with effective treatments for acute and chronic pain. It offers expert guidance on both interventional and non-interventional strategies, provided by respected academic physicians who practice evidence-based medicine at major universities and affiliated ACGME-accredited Pain Medicine Training programs"--Publisher's description.

Contents:
Basic science of pain
Headache
Central pain syndromes
Visceral pain: mechanisms, syndromes, and treatment
Neuropathic pain
Musculoskeletal pain
Palliative care and cancer pain
Complementary and integrative health
Pain and addiction
Geriatric pain management
Cannabis in pain
Inpatient pain
Pain care essentials: interventional pain
Rehabilitation in pain medicine
Comorbid chronic pain and posttraumatic stress disorder: current knowledge, treatments, and future directions
Opioids in pain
Regenerative medicine
Future research in pain.

Contents:
Emerging concepts of pain therapy based on neuronal mechanisms
The pharmacology of nociceptor priming
Sodium channels and pain
Role of nerve growth factor in pain
Central sensitization in humans: assessment and pharmacology
Nitric oxide-mediated pain processing in the spinal cord
The role of the endocannabinoid system in pain
The role of glia in the spinal cord in neuropathic and inflammatory pain
Plasticity of inhibition in the spinal cord
Modulation of peripheral inflammation by the spinal cord
The relationship between opiods and immune signalling in the spinal cord
The role of proteases in pain
Amygdala pain mechanisms
Itch and pain differences and commonalities
Index.

Summary: This book provides a comprehensive review of the, challenges, risk, stratification, and approaches and techniques needed to improve pain control in ambulatory surgery centers (ASCs). It addresses not only the management of acute perioperative pain but also describes modalities that could potentially reduce the risk of evolution of acute pain into chronic pain, in addition to weaning protocols and follow ups with primary surgical specialties and pain physicians as needed. Organized into five sections, the book begins with the foundations of managing ASCs, with specific attention paid to the current opioid epidemic and U.S. policies relating to prescribing opioids to patients. Section two and three then explore facets of multimodal analgesia and non-operating room locations, including the use of ultrasounds, sedation in specific procedures, regional anesthesia, ketamine infusions, and the management of perioperative nausea and intractable pain in outpatient surgery. Section four examines the unique challenges physicians face with certain patient demographics, such as the pediatric population, those suffering from sleep apnea, and those with a history of substance abuse. The book closes with information on discharge considerations, ambulatory surgery protocols, recovery room protocols, and mandatory pain management services. An invaluable reference for all health personnel and allied specialties, Pain Control in Ambulatory Surgery Centers (ASCs) meets the unmet need for a resource that covers optimum pain control in patients undergoing outpatient surgery as well as the urgent ASCs challenges that are presented on an immense scale with national and international impact. .

Contents:
Academic and Non-academic Ambulatory Surgery Centers and Hospital Outpatient Departments
Opioid Epidemic
Current US Policy for Opioid Prescribing
Rationale and Goals for Optimal Pain Control in ASCs
Challenges of Pain Control in Ambulatory Surgery Setting
Assessment and Optimization of Available Resources for Pain Control
Benefits of optimum pain control in ASCs
Structuring Pain Control Regimens in ASCs
Preoperative Planning
Comprehensive Pain Management: Opioid Naïve Vs Opioid Tolerant
Risks and Benefits of Opioids in Chronic/Cancer Pain
Maximization of non-opioid multimodal therapy in ASCs
Use of Ultrasound in an Ambulatory Setting
Use of Regional anesthesia/Neuraxial anesthesia in ASCs
Ketamine infusions
Management of Perioperative Nausea and Intractable Pain in Outpatient Surgery
Sedation for Interventional Pain Procedures
Sedation and Analgesia for GI Procedures
Management of Perioperative Pain for IR Procedures
Management of Perioperative Pain for Bronchoscopy
Perioperative management of obstructive sleep apnea patients in an ambulatory setting
Special Considerations
Management of Pediatric Pain in an Ambulatory Setting
Pain management in former addicts on MAT (Medication assisted treatment)
Special Considerations
Medical Marijuana and Active Substance Abuse
Special Considerations
Indwelling Intrathecal Pumps and Spinal Cord Stimulators
Discharge from Recovery Room in Ambulatory Surgery Centers
Recovery Room Protocols for nursing in ASCs and HOPDs
Weaning protocols for Ambulatory Surgery
Role of a Focused Ambulatory Pain Specialist
Inclusion of mandatory pain management services in ASCs
New Vistas: Opioid Sparing Multimodal Therapy in the Post-Operative Period. .

Contents:
How do pain genes affect pain experience? / Marshall Devor
Conservation of pain genes across evolution / Thang Manh Khuong and G. Greg Neely
Defining human pain phenotypes for genetic association studies / Christopher Sivert Nielsen
Genetic contributions to pain and analgesia : interactions with sex and stress / Roger B. Fillingim and Jeffrey S. Mogil
Monogenic pain disorders / Geoff Woods
Alternative pre-mRNAsplicing of mu opioid receptor gene: molecular mechanisms underlying the complex actions of mu opioids / Ying-Xian Pan
Discovering multi-locus associations with complex pain phenotypes / Chia-Ling Kuo, Luda Diatchenko, Dmitri Zaykin
Overlapping phenotypes : genetic contribution to nausea and pain / Charles C. Horn
A counterpart to pain : itch / Adam P. Kardon and Sarah E. Ross
Translating genetic knowledge into clinical practice for musculoskeletal pain conditions / Luda Diatchenko, Shad B. Smith, William Maixner
The human chronic pain phenome : mapping non-genetic modifiers of the heritable risk / Ze'ev Seltzer, Scott R. Diehl, Hance Clarke and Joel Katz.

Summary: This book addresses all pain imaging aspects related to both the central nervous system and the body (thorax, abdomen and pelvis), thus updating the international literature on the topic. By adopting a clinical-radiological approach and offering a comprehensive differential diagnosis for a number of painful syndromes (many of which can mimic one other), the work aims to support and enhance the diagnostic management of these patients, suggesting the most appropriate diagnostic algorithm. The book is divided into separate sections for each anatomical macro-area, and the chapters cover the respective topics from both clinical and radiological perspectives. Further, the book includes extensive electronic supplementary material. As such, it offers an invaluable tool for radiologists, neuroradiologists and clinicians working in internal medicine, surgery and neurology, and could also be used in residency programs for these group.

Contents:
Intro; Foreword; Preface; Contents;
1: Mechanisms of Pain; 1.1 Peripheral Mechanisms; 1.2 Spinal Mechanisms; 1.3 Central Mechanisms and Pain Matrix; References;
2: Brain Imaging of Pain; 2.1 Introduction; 2.2 Structural and Functional Neuroimaging Techniques; 2.2.1 Magnetic Resonance Imaging (MRI); 2.2.2 Functional Magnetic Resonance Imaging (fMRI); 2.2.3 PET; 2.2.4 MEG; 2.2.5 NIRS; 2.3 Structural Neuroimaging of Pain; 2.3.1 Central Post Stroke Pain; 2.3.2 Multiple Sclerosis; 2.4 Functional Neuroimaging of Pain; 2.4.1 Pain Network and Connectivity; 2.4.2 Pain in Infants 2.4.3 Chronic Pain2.4.4 Phantom Limb Pain (PLP); References;
3: Headache: Clinical Features; 3.1 Primary Headaches; 3.1.1 Migraine; 3.1.1.1 Premonitory Phase; 3.1.1.2 Aura; Types of Aura Symptoms; Visual Aura; Sensory Aura; Language Aura; Motor Aura; Less Typical Aura Symptoms; 3.1.1.3 Headache; 3.1.1.4 Postdrome; 3.1.2 Tension-Type Headache; 3.1.3 Trigeminal Autonomic Cephalalgias (TACS); 3.1.3.1 Cluster Headache; 3.1.3.2 Paroxysmal Hemicrania; 3.1.4 SUNCT/SUNA; 3.1.4.1 Hemicrania Continua; 3.1.5 Other Primary Headache Disorders; 3.1.5.1 Primary Cough Headache 3.1.6 Primary Exercise Headache3.1.7 Primary Headache Associated with Sexual Activity; 3.1.8 Primary Thunderclap Headache; 3.1.9 Other Primary Headache Disorders; 3.2 Secondary Headaches; 3.2.1 Subarachnoid Haemorrhage; 3.2.2 Intracerebral Haemorrhage; 3.2.3 Cerebral Venous Thrombosis; 3.2.4 Cervical Artery Dissection; 3.2.5 Brain Tumours; 3.2.6 Intracranial Infections; References;
4: Imaging of Headache; 4.1 Introduction; 4.2 Imaging Modalities; 4.3 Imaging Findings; 4.3.1 Primary Headaches; 4.3.1.1 Migraine; Hemiplegic Migraine; Retinal Migraine; Chronic Migraine Migrainous Infarction4.3.1.2 Tension-Type Headache (TTH); 4.3.1.3 Trigeminal Autonomic Cephalalgias (TACs); 4.3.2 Secondary Headaches; 4.3.2.1 Headache Attributed to Trauma or Injury to the Head and/or Neck; 4.3.2.2 Headache Attributed to Cranial or Cervical Vascular Disorder; Ischemic Stroke; Subarachnoid Hemorrhage (SAH); Other Intracranial Hemorrhages; Cervical Carotid or Vertebral Artery Dissection; Cerebral Venous Sinus Thrombosis (CVST); Reversible Vasoconstriction Syndrome (RCVS); Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) 4.3.2.3 Headache Attributed to Nonvascular Intracranial DisordersSpontaneous Intracranial Hypotension; Increased Cerebrospinal Fluid Pressure; Intracranial Neoplasia; Chiari Malformation Type I; 4.3.2.4 Headache Attributed to Intracranial Infection; 4.3.2.5 Painful Cranial Neuropathies and Other Facial Pains; Glossopharyngeal Neuralgia; Tolosa-Hunt Syndrome; Optic Neuritis; References;
5: Trigeminal Nerve: Clinical Features; 5.1 Introduction; 5.2 Pathophysiology; 5.3 Clinical Features; 5.3.1 Trigeminal Neuralgia; 5.3.2 Classical Trigeminal Neuralgia

Summary: Pain management is a vast subject and is changing rapidly. Finding a good resource for learning, however, is difficult. Most of the available books are lengthy volumes including many details irrelevant to physicians sitting for examinations or assessment. Furthermore, books aimed at assisting preparation for entire anaesthesia exams typically address pain management in only one chapter or a few pages. This book covers the entire curriculum relating to pain management and will make it easy to learn all aspects of the subject by covering key concepts in a reader-friendly manner. It comprises nine concise and simple chapters that aim to impart the maximum information within a limited space. These chapters address anatomy, assessment of pain, diagnosis of pain, pharmacology, non-pharmacological pain management, acute and chronic pain management, pain management in special groups, and special techniques. Pain Management: Essential Topics for Examinations will be an ideal resource for those who plan to sit for examinations, wherever they are based in the world. In addition, it will be an invaluable reference for higher and advanced pain trainees, residents, and physicians working in chronic pain.

Contents:
Pain Pathway
Nociceptors
Pain Processing
Neuropathic Pain
Patient Evaluation
Assessment and Measurement of Acute Pain
Psychological Assessment of Chronic Pain
Assessment of Neuropathic Pain
Pain Assessment in Paediatrics
Assessment of Pain in Elderly
Imaging
Sodium Channels
Potassium and Calcium Channels
Serotonergic Receptors
Glutamate and GABA Receptors
Opioids
Opioids-Clinical Use
Nonsteroidal Anti-inflammatory Drugs
NSAIDs 2
Antidepressants
Anticonvulsants
Topical Agents
Miscellaneous Drugs
Placebo and Nocebo Effect
Acupuncture
Biofeedback
Cognitive Behavioural Therapy
Burns
Sickle Cell Disease
Painful Neuropathies
Phantom Pain Syndromes
CRPS
Postherpetic Neuralgia
Central Pain Syndromes
Headache
Fibromyalgia
Trigeminal Neuralgia
Pain Management and Substance Abuse
Epidemiology and Mechanisms of Cancer Pain
Assessment of Cancer Pain
Breakthrough Pain
Mucositis
Lumbar Radiculopathy
Lumbar Facet Joint Pain
Lumbar Spinal Stenosis
Lumbar Discogenic Pain
Sacroiliac Joint Pain
Piriformis Syndrome
Cervical Radiculopathy
Cervical Facet Pain
Radiofrequency Treatment
Spinal Cord Stimulation.

Contents:
I. Evaluation of the Pain Patient
Physiology of Pain
Obtaining a Pain History
Physical Exam: Approach to the Pain Patient
Diagnostic Imaging
Painful Surgical Referrals and Emergencies
Urine Toxicology Screen
Opioid Overdose and Withdrawal
Detoxification From Opiates and Benzodiazepines
Discharging the Non-Compliant Patient
II. Medication Management for the Pain Patient
Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Muscle Relaxants and Antispasticity Medications
Neuropathic Antidepressant Medications
Neuropathic Anticonvulsant Medications
Opioid Medications
Topical Analgesic Medications
III. Clinical Care for the Pain Patient
Headache
Facial Pain
Post Herpetic Neuralgia
Joint Pain
Post-Amputation Pain
Spinal Pain
Chronic Pelvic and Abdominal Pain
Neuropathic pain
Complex Regional Pain Syndrome (CRPS)
Fibromyalgia
Sickle Cell Disease
Cancer Pain
Palliative Care
Hospice Medicine
IV. Pain Management in Patients with Special Circumstances
Pain Management in Patients with Renal Impairment
Pain Management in Patients with Hepatic Impairment
Pain Management During Pregnancy and Breast Feeding
Pain Management in Geriatric Patients
Acute Post-Surgical Pain and PCA Management
V. Interventional Management for the Pain Patient
Hematologic-altering Medications and Spinal Injections
Injections in Patient?s with Bleeding Risks and Comorbid Conditions
Spinal Procedure Injectables
Radiation Safety and Monitoring
Cervical Injections
Thoracic Injections
Lumbar Injections
Sacral Injections
Sympathetic Block Injections
Neuromodulation
Intrathecal Drug Delivery Systems
Joint, Tendon and Nerve Injections
Regenerative Injection Therapy
Injection Complications and Management.

Summary: This book focuses on the modern clinical management of acute and chronic pain syndromes. It not only presents information in a clinically illuminating format, but in a manner that is cognizant of the current prescription opioid epidemic. Divided into seven sections, this book covers acute pain, common pain conditions, regional pain problems, interdisciplinary evaluation and treatment, medical treatments and pain in different stages of life. Concluding with the exploration of several special topics, the last section includes an important discussion on the regulatory and legal issues in the use of controlled substances. Chapters are concise and relevant, with an emphasis on treatment based upon evidence from clinical trials and interpretation by practitioners in the field. Expertly written text is further supplemented by high-quality figures, images and tables outlining proven treatments with drug, dose or other information describing details of treatment. Timely, informative, and socially conscious, Pain Management for Clinicians: A Guide to Assessment and Treatment is a valuable reference for clinicians who manage patients with chronic and common pain problems.

Contents:
Intro
Introduction
Contents
Contributors
Part I: Acute Pain
Chapter 1: Pain Assessment and Treatment for the Trauma and Burn Patient
Pain Management of the Trauma Patient
Introduction
Traumatic Pain Pathologies
Assessment of Pain in the Trauma Patient
Opioid Medications
Non-opioid Medications
Interventional Pain Procedures
Non-pharmacological Interventions
Special Populations
Summary of Treatments for Trauma Pain (Tables 1.1, 1.2, 1.3, and 1.4)
Pain Management for the Burn Patient
Introduction
Burn Insult Classification Steroids
Local Anesthetics
Gabapentinoids
Ketamine
Alpha-2-agonists
Opioids
Beta-Blockers
Potentially Helpful Agents with Less Evidence
Nonpharmacologic Treatments that May Be Useful
Future Perioperative Pain Management Modalities
Opioid-Free Analgesia?
Charts
Evidence-Based Treatment
Strong Evidence
Weak or Insufficient Evidence
Emerging or Promising Treatments
Timing Basic Options
Enhanced Recovery After Surgery Example Pain Management Protocols
Inguinal Hernia Repair (Ambulatory: Mild to Moderate Pain Anticipated) Laparoscopic Cholecystectomy (Ambulatory: Moderate Pain Anticipated)
Open Reduction Internal Fixation Calcaneus (Ambulatory: Severe Pain Anticipated)
Multilevel Spine Fusion (Hospitalized: Severe pain, Opioid tolerance, and Comorbid Conditions Anticipated)
Open Thoracotomy (Hospitalized: Severe Pain and Comorbid Conditions Anticipated)
References
Chapter 3: Inpatient Pain Management
Acute Pain Service with Regional and Neuraxial Blocks
Upper Extremity Pain
Thoracic Pain
Abdominal Pain
Lower Extremity
Summary of Treatment Principles and Methods Formulation of Individualized Treatment and Rehabilitation Plan
Evaluation of Medications for Effectiveness, Side Effects, Dependency, and Interactions
Medications
Classes of Medications
Antiepileptics
Opioids
Treatment of the Psychological Distress that Often Accompanies Intractable Pain
Relaxation Training
Biofeedback
Group Therapy
Family Involvement
Medications
Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)
Tricyclic Antidepressants (TCAs)
Selective Serotonin Reuptake Inhibitors (SSRIs)
Physical Function/Behavior Modification

Summary: This book addresses relevant issues to enhance pain management nurses need to advocate for effective pain treatment in the elderly. Significant changes in the evolving nursing and healthcare environment require adequate information on this topic, as pain is a very challenging area. As other care professionals, nurses are daily confronted with issues on pain assessment and management. This volume offers an overview within an evolving health environment, in which nurses dealing with pain play a growing role. It showcases best practices in pain assessment and management, details non pharmacological and pharmacological treatments. It also addresses core issues defined by the International Association for the Study of Pain (IASP), such as knowledge translation, that are most relevant for clinical nurses, student nurses, nurse researchers as well as other care professionals.

Summary: "For more than 30 years, the highly regarded Secrets Series® has provided students and practitioners in all areas of health care with concise, focused, and engaging resources for quick reference and exam review. Pain Management Secrets, 4th Edition, features the Secrets' popular question-and-answer format that also includes lists, tables, and an easy-to-read style - making reference and review quick, easy, and enjoyable"--Publisher's description.

Contents:
I. Overview. Definitions
Classification of pain
Basic mechanisms
Topiceuticals
II. Clinical approach. History taking in the patient with pain
Physical examination of the patient with pain
Pain measurement
Psychological assessment of chronic patients
III. Clinical syndromes defined by pain. Neuroimaging in the patient with pain
Tension-type headache
Migraine
Cluster headache
The paroxysmal hemicranias
Subarachnoid hemorrhage
Brain tumor headaches
Increased and decreased intracranial pressure
Temporal giant cell arteritis
Headaches associated with systemic disease
Trigeminal neuralgia
Glossopharyngeal and other facial neuralgias
Low back pain
Neck and arm pain
Abdominal pain
Chronic pelvic pain
Fibromyalgia and myofascial pain
IV. Syndromes in which pain is a significant component. Postoperative pain management
Cancer pain syndrome
Pain in rheumatoid arthritis and osteoarthritis
Neuropathic pain
V. Psychological syndromes
VI. Special patient populations. Pain in children
Pain in the older patient
VII. Pharmacologic management. Nonsteroidal anti-inflammatory drugs
Opioid analgesics
Addiction and pain management
Regulatory issues
Adjuvant analgesics
VIII. Nonpharmologic management. Temporary neural blockade
Permanent neural blockade and chemical ablation
Sympathetic neural blockade
Intraspinal opioids
Neurostimulatory and neuorablative pocedures
Psychological constructs and treatment interventions
Physical modalities: adjunctive treatments to reduce pain and maximize function
Pain clinics
Interventional pain management
Complementary and alternative medicine.

Summary: This book presents a contemporary review of the field of Pain Therapeutics, including the historical medicines which still dominate standard of care treatments, as well as the new mechanisms and combinations/reformulations that have dominated the regulatory approvals over the last decade. In addition this book provides a deep review of the key biological mechanisms currently under investigation for their utility into the treatment of pain, such as ion channels, opiates and others. Additional discussion highlights the current challenges of pain research, covering a range of topics from difficulties in identifying new targets from pre-clinical models to the current regulatory and commercial challenges. This background sets the scene for recent scientific changes in pain research, such as the drive for genetic validation of targets and the derivation of human cell platforms from stem cells. Finally the book covers the discovery and development stories for two pain products approved in the last decade. These case studies for Lyrica and the Butrans patch, will give insight into the discovery and development challenges and successes for both an oral and non-oral product.

Summary: "As a country, the United States overinvests in medical care, often at the expense of the social, economic, and cultural forces that produce health. Indeed, the rise of medicine as a cornerstone of American life and culture has coincided with a social and political devaluation of factors demonstrated to mean more to one's vitality than anything else-influences like where one lives, works, and plays; livable wages that create opportunity for healthy living; and gender and racial equity. As such, this book pushes the conversation around American health toward matters of class, money, and culture. It highlights how the structural components of everyday life ultimately determine who gets to be healthy in today's America. In doing so, it makes a case for reframing the political discourse on public health in less myopic, more effectual terms"-- Provided by publisher.

Contents:
It's personal : pain as a human experience
More than a survivor : the resiliency of hope
Caught in a web : the complexity of pain
Friendly fire : rejecting stigma
The new scarlet letter : addiction and recovery
Soul mates : love amid pain
The God prescription : spirituality and pain
Everyday saints and unsung heroes : caregiving and care receiving
Coming of age : self-advocacy
The chilling effect : opioids and law enforcement
A human right : toward curing.

Contents:
Evaluation of articles on therapy
Evaluation of articles on diagnosis
Evaluation of articles on harm
Evaluation of articles on prognosis
Evaluation of systematic reviews
Evaluation of clinical practice guidelines
Evaluation of articles on screening
Literature searches.

Summary: Advances in genome-scale DNA sequencing technologies have revolutionized genetic research on ancient organisms, extinct species, and past environments. When it is recoverable after hundreds or thousands of years of unintended preservation, "ancient DNA" (or aDNA) is often highly degraded, necessitating specialized handling and analytical approaches. Paleogenomics defines the field of reconstructing and analyzing the genomes of historic or long-dead organisms, most often through comparison with modern representatives of the same or similar species. The opportunity to isolate and study paleogenomes has radically transformed many fields, spanning biology, anthropology, agriculture, and medicine. Examples include understanding evolutionary relationships of extinct species known only from fossils, the domestication of plants and animals, and the evolution and geographical spread of certain pathogens. This pioneering book presents a snapshot view of the history, current status, and future prospects of paleogenomics, taking a broad viewpoint that covers a range of topics and organisms to provide an up-to-date status of the applications, challenges, and promise of the field. This book is intended for a variety of readerships, including upper-level undergraduate and graduate students, professionals and experts in the field, as well as anyone excited by the extraordinary insights that paleogenomics offers.

Contents:
Part1. Concepts, Technical Advances and Challenges
Chapter1. Technical Advances and Challenges in Genome-Scale Analysis of Ancient DNA
Chapter2. Paleoproteomics: An Introduction to the Analysis of Ancient Proteins by Soft Ionization Mass Spectrometry
Chapter3. Ancient RNA
Chapter4. Ancient Epigenomics
Part2.
Chapter5. Ancient Pathogens Through Human History: A Paleogenomic Perspective
Chapter6. Paleovirology: Viral Sequences from Historical and Ancient DNA
Chapter7. Reconstructing Past Vegetation Communities Using Ancient DNA from Lake Sediments
Chapter8. Archaeogenomics and Crop Adaptation
Chapter9. Herbarium Genomics: Plant Archival DNA Explored
Chapter10. Paleogenomics of Animal Domestication
Chapter11. Paleogenomic Inferences of Dog Domestication
Chapter12. Of Cats and Men: Ancient DNA Reveals How the Cat Conquered the Ancient World
Chapter13. An Ancient DNA Perspective on Horse Evolution
Chapter14. Primate Paleogenomics
Chapter15. Structural Variants in Ancient Genomes
Chapter16. Genomics of Extinction.

Summary: "Only recently was it determined that two of the world's most devastating plagues, the plague of Justinian and the medieval Black Death, were caused by distinct strains of the same pathogen. Use of paleomicrobiological techniques led to this discovery. This work is just one example of the historical mysteries that this emerging field has helped to clarify. Others, such as when tuberculosis began to afflict humans, the role of lice in plague pandemics, and the history of smallpox, are explored and further illuminated in Paleomicrobiology of Humans. Led by editors Michel Drancourt and Didier Raoult, the book's expert contributors address larger issues using paleomicrobiology. These include the recognition of human remains associated with epidemic outbreaks, identification of the graves associated with disasters, and the discovery of demographic structures that reveal the presence of an epidemic moment. In addition, this book reviews the technical approaches and controversies associated with recovering and sequencing very old DNA and surveys modern human diseases that have ancient roots."--Back cover.

Contents:
1. Demographic Patterns Distinctive of Epidemic Cemeteries in Archaeological Samples / Sacha Kacki
2. Characterization of the Funeral Groups Associated with Plague Epidemics / Michel Signoli
3. Paleogenetics and Past Infections: the Two Faces of the Coin of Human Immune Evolution / Didier Raoult
4. A Personal View of How Paleomicrobiology Aids Our Understanding of the Role of Lice in Plague Pandemics / Didier Raoult
5. Sources of materials for Paleomicrobiology / Gerard Aboudharam
6. Paleomicrobiology Data: Authentification and Interpretation / Michel Drancourt
7. Human Coprolites as a Source for Paleomicrobiology / Matthieu Le Bailly
8. Ancient Resistome / Jean-Marc Rolain
9. The History Of Epidemic Typhus / Didier Raoult
10. Paleopathology of Human Infections: Old Bones, Antique Books, Ancient and Modern Molecules / Olivier Dutour
11. Past Bartonelloses / Pierre-Edouard Fournier
12. Paleomicrobiology of Human Tuberculosis / Helen Donoghue
13. Paleomicrobiology of Leprosy / Mark Spigelman and Mauro Rubini
14. Past Intestinal Parasites / Matthieu Le Bailly and Adauto Araujo
15. Paleopathology and Paleomicrobiology of Malaria / Andreas Nerlich
16. History of Smallpox and Its Spread in Human Populations / Catherine Theves, Eric Crubezy, and Philippe Biagini
17. Cholera / Donatella Lippi, Eduardo Gotuzzo, and Saverio Caini
18. Human Lice in Paleoentomology and Paleomicrobiology / Rezak Drali, Kosta Y. Mumcuoglu, and Didier Raoult.

Summary: This handbook is the definitive resource for understanding current mental health policy controversies, options, and implementation strategies. It offers a thorough review of major issues in mental health policy to inform the policy-making process, presenting the pros and cons of controversial, significant issues through close analyses of data. Some of the topics covered are the effectiveness of various biomedical and psychosocial interventions, the role of mental illness in violence, and the effectiveness of coercive strategies. The handbook presents cases for conditions in which specialized mental health services are needed and those in which it might be better to deliver mental health treatment in mainstream health and social services settings. It also examines the balance between federal, state, and local authority, and the financing models for delivery of efficient and effective mental health services. It is aimed for an audience of policy-makers, researchers, and informed citizens that can contribute to future policy deliberations.

Contents:
Machine generated contents note: 1. Mental Health Policy: Fundamental Reform or Incremental Change?
2. Division of Labor: Function Shifts and Realigned Responsibilities in the Evolving Mental Health Services System / Joseph P. Morrissey / Howard H. Goldman
3. Economic Perspectives on the Organization and Governance of Mental Health Care / Joseph P. Morrissey / Howard H. Goldman
4. What Is the Meaning of Recovery? / Richard G. Frank / Sherry A. Glied
5. Balancing Access to Medications and Psychosocial Treatments / Larry Davidson / Timothy Schmutte
6. Are There Enough Inpatient Psychiatric Beds? / Patricia A. Aredn / Anna Ratzliff
7. Mandated Community Treatment in Services for Persons with Mental Illness / Marisa Elena Domino / Eric Slade
8. Shared Decision-Making and Self-Directed Care / Marvin S. Swartz / Jeffrey W. Swanson
9. Suicide Prevention: Rising Rates and New Evidence Shape Policy Options / Michelle P. Salyers / Yaara Zisman-Ilani
10. How Should the United States Respond to the Opioid Addiction and Overdose Epidemic? / Michael F. Hogan
11. Early Intervention in Psychosis: From Science to Services / Keith Humphreys / Harold A. Pollack
12. Policy Effects on Mental Health Status and Mental Health Care Disparities / Thomas E. Smith / Lisa B. Dixon
13. Mental Health Insurance Parity: How Full Is the Glass? / Rupinder K. Legha / Lonnie R. Snowden / Jeanne Miranda
14. Housing for People with Serious Mental Illness / Haiden A. Huskamp
15. What Is the Role of Schools in the Treatment of Children's Mental Illness? / Josh Leopold
16. Policy Issues Regarding Employment for People with Serious Mental Illness / Jeff Q. Bostic / Libby K. Nealis / Sharon A. Hoover
17. Adults with Serious Mental Illnesses Who Are Arrested and Incarcerated / Gary R. Bond / Ellen R. Meara / Robert E. Drake
18. Gun Violence Prevention and Mental Health Policy / Fred Osher / Michael Thompson
19. Stigma as a Mental Health Policy Controversy: Positions, Options, and Strategies for Change / Marvin S. Swartz / Colleen L. Barry / Jeffrey W. Swanson
20. How Shall We Promote Citizenship and Social Participation? / Bernice A. Pescosolido
21. Evidence-Based Practices or Practice-Based Evidence: What Is the Future? / Michael Rowe / Allison N. Ponce
22. New Financing Models in Behavioral Health: A Recipe for Efficiency or Under-Provision? / Marcela Horvitz-Lennon
23. Mental Health Disability, Employment, and Income Support in the Twenty-First Century / Thomas G. McGuire.

Summary: Palliative Care for Chronic Cancer Patients in the Community: Global Approaches and Future Applications offers a much-needed account of the current state of global palliative care in the community - the good, the bad and, especially, the hopeful. This extraordinary compendium, with chapters form 46 countries, edited by Professor Michael Silbermann, tells the remarkable stories of palliative care - from grass-root efforts by volunteers in resource-constrained countries such as India to the full integration of palliative care in high-resource countries such as the United States, the United Kingdom, New Zealand and Australia. What is so unique about this book is that it captures the enormous range and diversity of palliative care efforts: some led by nurses (Iran), some led by governments (Turkey) and many led by local charities and non-governmental agencies. Readers of this textbook can also learn about the challenges of a government-led palliative care initiative in the post-genocide era in Rwanda or the attempts to provide palliative care services in the conflict zones of Iraq, Palestine and Sudan. Contextual issues requiring cultural sensitivity in Afghanistan, Latin America and the Middle East present a real picture of both the exceptional leadership and environmental hardships that palliative care advocates face in their journeys forward. Each of the 53 chapters in the book tells a narrative of the country's own experience, thus creating a source of on the ground information outlining the barriers, challenges and successes as individual efforts progress. Many reports in the book point toward real change and hope as they relate to healthcare providers becoming empowered advocates for their patients. There are high expectations for the role of nurses to continue to grow. Educating and engaging patients, and the families in their care, has had a measurably positive impact on outcomes. The collaborative spirit of this book gives voice to the incredible vision, tenacity and resilience of the teams of professionals and their supporters who work in palliative care, particularly those who work in the community. In addition, it underscores that all future efforts can only be successful with the concerted and continuous commitments of governments, academics and NGOs across and within national boundaries. - HRH Princess Dina Mired President - Union for International Cancer Control (UICC).

Summary: One of the most challenging roles of the psycho-oncologist is to help guide terminally-ill patients through the physical, psychological, and spiritual aspects of the dying process. Patients with cancer, AIDS, and other life-threatening illnesses are at increased risk for the development of major psychiatric complications, and have an enormous burden of both physical and psychological symptoms. Concepts of adequate palliative care must be expanded beyond the current focus on pain and physical symptom control to include the psychiatric, psychosocial, existential, and spiritual aspects of care. The psycho-oncologist, as a consultant to or member of a palliative care team, has a unique role and opportunity to fulfill this promise of competent and compassionate palliative care for those with life-threatening illnesses. Psychosocial Palliative Care guides the psycho-oncologist through the most salient aspects of effective psychiatric care of patients with advanced illnesses. This handbook reviews basic concepts and definitions of palliative care and the experience of dying, the assessment and management of major psychiatric complications of life-threatening illness, including psychopharmacologic and psychotherapeutic approaches, and covers issues such as bereavement, spirituality, cultural sensitivity, communication and psychiatric contributions to common physical symptom control. A global perspective on death and palliative care is taken throughout the text, and an Appendix provides a comprehensive list of international palliative care resources and training programs. -- Provided by publisher.

Contents:
Palliative Care for Older People : An introduction
A public health perspective to palliative care for older people: An introduction
Organization of and policies for palliative care for older people
Long-term Care Systems
Development of palliative care in long-term care
Development of integrated person-centred care in long-term care
Policies on palliative care for older people in Africa
Policies on palliative care for older people in Asia
Policies on palliative care for older people in Australia
Policies on palliative care for older people in Europe
Policies on palliative care for older people in North America
Policies on palliative care for older people in Latin America and the Caribbean
Socio-cultural and clinical context of dying in old age
Dying in place in old age: public health challenges
Symptoms and trajectories experienced by older people approaching and at the end of life: Implications to care
End-of-life decisions for older patients who are approaching death
Ethical issues in palliative care for older people
Cultural issues in palliative care for older people
Spirituality and spiritual palliative care in older people
Use and access of palliative care for older people
Use of generalist and specialist palliative care for older people
Compassionate communities: Caring for older people towards the end of life
Palliative care for older people with dementia
Collaboration between professionals as a necessary condition for palliative care
Communication and advanced care planning (ACP) in older people
Innovations in palliative care for older people
EU civil society initiatives to protect the right to live and die in dignity
Care pathways for older people in need of palliative care
A program for advance care planning for older people: Respecting Patient Choices
Conclusion: What does a public health approach to improving palliative care in older people look like?
A public health approach to improving palliative care for older people

Summary: This book analyzes the main topics of Palliative Care in Cardiac Intensive Care Units (CICU), from the changing epidemiology of patients admitted to the ICU, to the main clinical and ethical issues. The changing epidemiology of patients has led to new and emerging patient needs at the end of life. Care has shifted from acute coronary syndrome patients towards elderly patients, with a high prevalence of non-ischemic cardiovascular diseases and a high burden of non-cardiovascular comorbid conditions: both increase the susceptibility of patients to developing life-threatening critical conditions. These conditions are associated with a significant symptom burden, high mortality rate, and increased length of stay. The main new challenges involve shared decision-making, symptom control (pain, dyspnea, etc.), and ethical issues (withholding/withdrawing life sustaining treatments, deactivation of implanted cardiac devices, palliative sedation), all of which necessitate formal education on end-of-life care. Written by opinion leaders in their respective fields, who share their experience with improving the cultural and clinical competence of medical/nursing teams, this volume is chiefly intended for cardiologists, anesthesiologists, palliative care doctors and nursing staff.

Contents:
Intro
Foreword
Preface
Acknowledgements
Contents
About the Author
1: Epidemiology and Patterns of Care in Modern Cardiac Intensive Care Units
1.1 Introduction
1.2 Is There a Background for the Evolution of CICU? From the Blitz-3 to Modern International CICU Registries
1.3 Aging, Comorbidity, and the Risk of Futility in CICU
1.4 The COVID-19 Tsunami and Its Effect on CICU
1.5 Conclusions
References
2: The Intensive and Advanced Treatments in the Cardiac Intensive Care Units
2.1 Introduction
2.2 Cardiac Arrest and Post-cardiac Arrest Syndrome 2.3 Advanced Heart Failure and End-Stage Heart Failure
2.4 Cardiogenic Shock (CS) and Low-Output Syndrome
2.5 Mechanical Circulatory Supports (MCSs)
2.6 Heart Replacement Therapies
2.7 Cardiac Implanted Electronic Devices (CIEDs)
2.8 Palliative Care in CICU
2.9 Palliative Inotrope Care
References
3: Symptom Assessment and Management
3.1 The Cardiologist's Palliative Competencies
3.2 Measuring a Symptom
3.2.1 Dyspnea
3.2.2 Pain
3.2.3 Thirst
3.3 Cognitive and Mood Disorders
3.3.1 Fatigue
3.3.2 Gastrointestinal Symptoms
References 4: The Meanings of Prognosis: When and How to Discuss It?
4.1 Introduction
4.2 Deciding Between Prognosis and Uncertainty
4.3 Criteria for Prognosis Definition
4.4 Communicating Prognosis
4.5 Barriers to Communication
4.5.1 The Disease
4.5.2 The Patient
4.5.3 Treatment Approach
4.5.4 The Doctor
4.6 Conclusions
References
5: Informed Consent, Advance Directives, and Shared Care Planning
5.1 Introduction
5.2 Legal and Ethical Aspects
5.3 Shared Care Planning and Advance Directives in Cardiology
5.4 Conclusions
References 6: Withholding or Withdrawing Life-Sustaining Treatments
6.1 Introduction
6.2 Forgoing Life-Sustaining Treatments: The Clinical Practice
6.3 Physician Preferences
6.4 Withdrawing Life-Sustaining Treatment: Arguments in Favor
6.5 Withholding Life-Sustaining Treatment: Arguments in Favor
6.6 Withdrawing or Withholding Life-Sustaining Treatments: Means or Goals?
6.7 Forgoing Life-Sustaining Treatments: How to Do
6.7.1 Ethical Principles
6.7.2 Decision to Forgo Life-Sustaining Treatments: Theoretical Approach 6.7.3 Decision to Forgo Life-Sustaining Treatments: The Goals
6.7.4 Withdrawing Life-Sustaining Treatments: Basics in Clinical Practice
6.8 Conclusions
References
7: Deactivation of Cardiac Implantable Electronic Devices (CIEDs) at the End of Life
7.1 Introduction
7.2 Implantable Cardioverter-Defibrillators (ICDs)
7.2.1 Ethical Problems
7.2.2 Information and Patient Awareness
7.2.3 The Opinion of Physicians and Nurses
7.3 Cardiac Pacemaker (PM)-Cardiac Resynchronisation Therapy-Pacemaker (CRT-P)
7.4 Conclusions
References

Summary: This book details the benefits of palliative care to improve the lives of patients with serious lung disease and their caregivers. Palliative care is specialized medical care for people living with a serious illness. This type of care is focused on providing relief from the symptoms and stress of a serious illness, and is often described as "an extra layer of support" for patients and their caregivers, as patients with malignant and nonmalignant lung disease experience great symptom burden and have advanced care planning needs. This book has three main objectives: Define the role of palliative care in advanced lung disease Incorporate a patient-centered perspective in describing symptom burden and interventions to improve quality of life Provide current initiatives to expand evidence-based practice and improve access to palliative care Written by leading experts in palliative care and respiratory medicine, the chapters seek to answer those objectives by first defining and describing palliative care, advanced lung disease, and inadequate palliative care in this patient population. Patient reported outcomes, quality of life, and interventions to help deal with the psychological toll of serious illness are then detailed, as well as pharmacological and non-pharmacological interventions for symptom management. Detailed information is additionally provided on current research studies and management for several lung diseases, including COPD, ILD, Lung Cancer, Pulmonary Arterial Hypertension, Neuromuscular disease, and pediatric lung disease. The more administrative aspects of palliative care programs are then covered with an example of a specialty palliative care program for advanced lung disease and advice on how to address policy that promotes palliative care. Finally, palliative care's role during a pandemic is thoughtfully considered. This book is an ideal guide for clinicians, nurses, hospital administrators, teachers, students to help them understand and fill unmet care needs that many patients with serious lung disease experience.

Contents:
Palliative Care in Lung Disease
An Introduction to Advanced Lung Disease
Inadequate Palliative Care in Lung Disease
Patient-Centeredness & Patient Reported Measures (PRM) in Palliation of Lung Disease
Quality of Life in Chronic Lung Disease
Breathlessness
Preparatory and anticipatory grief, anxiety and depression in life-limiting lung disease
Symptom Management in Advanced Lung Disease
Communication in Palliative Care
Palliative Care in COPD
Palliative care in interstitial lung disease
The Role of Palliative Care in Lung Cancer
Palliative care in patients with neuromuscular diseases
Palliative Care in Pulmonary Arterial Hypertension
Palliative Care for Children with Lung Diseases
Specialty Palliative Care Program ILD
Withdrawal of Mechanical Ventilation: Considerations to Guide Patient and Family Centered Care and the Development of Health Care Policy
Palliative Care during a Pandemic.

Summary: Palliative care provides comprehensive support for severely affected patients with any life-limiting or life-threatening diagnosis. To do this effectively, it requires a disease-specific approach as the patients? needs and clinical context will vary depending on the underlying diagnosis. Experts in the field of palliative care and oncology describe in detail the needs of patients with advanced cancer in comparison to those with non-cancer disease and also identify the requirements of patients with different cancer entities. Basic principles of symptom control are explained, with careful attention to therapy for pain associated with either the cancer or its treatment and to symptom-guided antineoplastic therapy. Complex therapeutic strategies for palliative cancer patients are highlighted that involve both cancer- and symptom-directed options and address a range of therapeutic aims. Issues relating to drug use in palliative cancer care are fully explored, and a separate section is devoted to care in the final phase. A range of organizational and policy issues are also discussed, and the book concludes by considering likely future developments in palliative care for cancer patients. Palliative Care in Oncology will be of particular interest to palliative care physicians who are interested in broadening the scope of their disease-specific knowledge, as well as to oncologists who wish to learn more about modern palliative care concepts relevant to their day-to-day work with cancer patients.

Contents:
1. Disease-specific oncology - disease-specific palliative care
2. Oncological and palliative care for patients with lung cancer and patients with breast cancer: two opposite ends of a spectrum
3. Palliative care for patients with haematological malignancies
4. Definition, pathophysiology, and assessment of pain
5. Therapy of cancer-related pain and cancer therapy-related pain
6. Radiation therapy in patients with non-curable cancer
7. Symptom management: the nursing view
8. The Liverpool Care pathway for the dying patient
9. The final phase
10. Options and problems of drug application in patients with advanced cancer
11. Drug interactions in palliative cancer care and oncology
12. Outpatient and inpatient structures: what does it need to integrate palliative care services?
13. Early palliative care
14. Psycho-oncology and palliative care: two concepts that fit into comprehensive cancer care
15. Cancer therapy in developing countries: the role of palliative care
16. Emergencies in oncology and crises in palliative care
17. Palliative care for patients participating in experimental or clinical oncology studies
18. The future of oncology palliative care.

Summary: This textbook is the first to focus on comprehensive interdisciplinary care approaches aimed at enhancing the wellbeing of children with cancer and their families throughout the illness experience. Among the topics addressed are the epidemiology of pediatric cancer distress, including physical, emotional, social, and spiritual dimensions; the role of the interdisciplinary team; communication and advance care planning; symptom prevention and management; care at the end of life; family bereavement care; and approaches to ease clinician distress. The contributing authors are true experts and provide guidance based on the highest available level of evidence in the field. The book has not only an interdisciplinary but also an international perspective; it will appeal globally to all clinicians caring for children with cancer, including physicians, nurses, psychosocial clinicians, and chaplains, among others.

Contents:
Epidemiology of suffering in childhood cancer
Impact of cancer on the child, parents, siblings and community.- The interdisciplinary oncology team and the role palliative care consultation.- Communication in pediatric palliative oncology
The relationship between cancer-directed therapy and the pediatric oncology experience
Easing physical distress
Easing psychological distress
Easing existential distress
Easing social distress
Care at the end of life
Family bereavement Care
Easing clinician distress.

Summary: Palliative Care Nursing, Fifth Edition, delivers advanced empirical, aesthetic, ethical and personal knowledge. This new edition brings an increased focus on outcomes, benchmarking progress, and goals of care. It expounds upon the importance of the cross-disciplinary collaboration introduced in the previous edition. Every chapter in Sections I, II, and III includes content written by a non-nursing member of the interprofessional team. Based on best-evidence and clinical practice guidelines, this text presents comprehensive, targeted interventions responsive to the needs of palliative and hospice patients and family. Each chapter contains compassionate, timely, appropriate, and cost-effective care for diverse populations across the illness trajectory.

Contents:
Understanding Palliative Care
Caring for the whole Person and His or Her Family
Physical Health: Threatening Diseases
Physical Health: Symptom management.

Summary: Offering practical, comprehensive coverage of the many nuanced technical and clinical aspects of this growing field, Palliative Radiation Oncology provides up-to-date clinical guidance in a thorough yet concise manner. In an easy-access format, it integrates basic science, pathologies, and research with clinical applications, covering different ways to approach problems, tumor assessment, precise target definition, and dosing-specific guidelines to minimize side effects/toxicities while balancing with desired outcomes.

Contents:
Foundations and principles of palliative care in oncology
Techniques and modalities
Foundations and principles of palliative radiation by body site or special population
Management of symptoms and treatment-related toxicities.

Summary: Rooted in everyday hospital medicine, Palliative Skills for Frontline Clinicians addresses the challenges of delivering complex care to patients living with serious illnesses. Spanning emergency medicine, internal medicine, surgery and various subspecialties, each chapter reads like a story, comparing usual care with a step-by-step palliative-based approach. This case-based book features a multidisciplinary, palliative-trained authorship, including neurologists, nephrologists, emergency physicians, surgeons, intensivists, and obstetricians. Divided into four parts, Palliative Skills for Frontline Clinicians outlines common clinical scenarios across settings and specialties to highlight unmet needs of patients with potentially terminal illnesses. Each case is broken down into the usual standard approach, and delves into detail regarding different palliative interventions that can be appropriate in those scenarios. These are meant to be practice changing; down to the actual words used to communicate with patients. In addition to the books focus on the principles of palliative care and the "art" of treating the patient, approaches to communication with the patients families for the best long-term outcomes are discussed. Concise and pragmatic, Palliative Skills for Frontline Clinicians is meant to be practice changing. It provides readers with both a new conceptual framework, as well as actual words to communicate with patients and medication doses for symptom management. It is an invaluable resource for non-palliative trained clinicians who wish to strengthen their palliative care skills.

Contents:
Part I: Emergency Medicine
High Yield Approach to the ED Goals of Care Conversation
A Palliative Approach to End Stage COPD
This POLST Makes No Sense
Treating Pain and Prognosticating in Metastatic Cancer
Complex Pain Management and Goals of Care in a Debilitated Cancer Patient
To Intubate or Not to Intubate: Ask the Right Questions
ED Approach to the Hospice patient
Part II: Inpatient Internal Medicine
"We cant let him starve": Artificial Nutrition in Patients with Advanced Dementia
Shared Decision-Making in the Setting of a Large Ischemic Stroke
Prognostication and Goals of Care in Advanced Parkinsons Disease
Saying Yes to Aggressive Measures: The Role of Neuropalliative Care in Critically Ill Patients with Potential for Recovery
"I am a Fighter": Recognizing and Responding to Cancer Metaphors
"What does the awake ventilated patient really want?": Shared-decision making in the ICU
A Mothers Love
Support Despite Disagreeing with Goals of Care
End-Stage Renal Disease and Shared Decision-Making Dilemmas
Discontinuing Continuous Renal Replacement Therapy (CRRT) in the Intensive Care Unit
Teaching Learners How to Approach Family Decisions as a Process
Part III: Surgery
Trach/PEG Consult in the ICU
Rescinding DNR Orders in the Operating Room
A Threshold Moment, Preserving Patient Dignity, and the Value of a Time Limited Trial
Between a Rock and a Hard Place: Anticipating Poor Surgical Outcomes while Honoring Patient Autonomy
Surgery for the Hospice Patient: When is it Appropriate?
Non-Operative Approach To Caring For The Ischemic Limb
Placing a Feeding Tube in a Patient with Dementia
Malignant Bowel Obstruction In A Dying Patient: To Operate Or Not?
Geriatric Trauma Decision-Making Based on Functional Outcomes
Part IV: Specialty Medicine
Decision by Surrogates for a Patient with a Psychiatric History
Palliative Approach to Patients with Concurrent Seriou s Illness and Substance Use Disorder
Responding To Spiritual Suffering And Hope During A Goals Of Care Conversation
Trisomy 18: Early And Concurrent Palliative Care Enhances Delivery And Neonatal Planning
Navigating Colleagues and Parents in the Pediatric ICU.

Summary: Palliative surgery can greatly contribute to improving symptom control and quality of life for terminal cancer patients. Owing to the advanced stage of the disease, however, this type of surgery is also associated with significant morbidity and mortality. It is therefore important for surgeons to have a sound understanding of the medical and scientific background underlying treatment decisions in palliative surgery, a foundation that this book provides. The opening chapters examine the relationship between palliative medicine and palliative surgery and address general issues including pain management and anesthesiological considerations. The role of palliative surgery in a wide range of disease settings is then thoroughly explored, including detailed information on surgical techniques and their indications and outcomes. This book will be an invaluable resource for all who wish to learn more about the emerging role of palliative surgery.

Contents:
Basic principles
Shoulder complex
Elbow complex
Hand
Hip and groin region
Knee joint
Foot
Soft tissues
Posterior pelvis
Lumbar spine
Thoracic spine and thoracic cage
Cervical spine
Head and jaw.

Contents:
Basic principles
Shoulder complex
Elbow complex
Hand
Hip and groin region
Knee joint
Foot
Soft tissues
Posterior pelvis
Lumbar spine
Abdominal Regional
Thoracic spine and thoracic cage
Cervical spine
Head and jaw.

Contents:
Introduction: Rationale for Precision Medicine Clinical Trials.- The Key Role of Pathology in the Context of Precision Medicine Trials
Basis for Molecular Genetics in Cancer
Microarrays Based Molecular Profiling to Identify Genomic Alterations
High Throughput Technologies: DNA and RNA Sequencing Strategies and Potential
Bioinformatics for Precision Medicine in Oncology
Assessment of Biomarkers? Predictive Value of Efficacy
Designs for Evaluating Precision Medicine Trials
Conclusions and Perspectives: Challenges for the Clinical Implementation of Precision Medicine Trials.

Summary: Easy to follow and redesigned algorithms and charts that help to organize medicine for maximum retention, especially for visual learners. Essential information for medical examinations, important correlations for clinical rotations and useful material for practicing clinicians. Not only will you quickly establish your strengths, but you will quickly improve on your areas of weakness. -- Publisher description

Contents:
Cardiovascular
Pulmonary Disorders
Gastrointestinal/Nutritional
Musculoskeletal/Rheumatology
EENT (Eyes, Ears, Nose, Throat) Disorders
Reproductive, obstetrics & gynecology
Endrocrine
Nephrology & urology
Neurologic disorders
Psychiatry & Behavioral science
Dermatologic Disorders
Infectious Diseases
Hematologic Disorders
Pharmacology
Pediatric blueprint topics.

Contents:
Book A.
1. Cardiovascular System
2. Pulmonary system
3. Gastrointestinal system/nutritional
4. Musculoskeletal system
5. EENT (eyes, ears, nose, & throat) disorders
6. Reproductive system (male and female)
Index
Book B. 7. Endocrine
8. Renal system
9. Genitourinary system (male and female)
10. Neurologic system
11. Psychiatry and behavioral disorders
12. Dermatologic system
13. Infectious Diseases
14. Hematologic system
15. Pediatric pearls
Index.

Contents:
Book A.
1. Cardiovascular System
2. Pulmonary system
3. Gastrointestinal system/nutritional
4. Musculoskeletal system
5. EENT (eyes, ears, nose, & throat) disorders
6. Reproductive system (male and female)
Index
Book B. 7. Endocrine
8. Renal system
9. Genitourinary system (male and female)
10. Neurologic system
11. Psychiatry and behavioral disorders
12. Dermatologic system
13. Infectious Diseases
14. Hematologic system
15. Pediatric pearls
Index.

Contents:
Elevated Amylase and Lipase: Physiology Including Non-Pancreatitis Related Elevations
Acute Pancreatitis
Chronic Pancreatitis
Recurrent Acute Pancreatitis
Steroid-Responsive Chronic Pancreatitides: Autoimmune Pancreatitis and Idiopathic Duct Centric Chronic Pancreatitis
Pancreas Adenocarcinoma and Ampullary Cancer
Neuroendocrine Tumors of the Pancreas
Cystic Lesions of the Pancreas
Bile Duct: Brief Anatomy, Investigations Used
Gallstone Disease
Choledocholithiasis including Acute Cholangitis
Benign Biliary Strictures
Cholangiocarcinoma
Autoimmune Liver Diseases: Primary Sclerosing Cholangitis
Gallbladder Cancer
Motility Disorders. .

Summary: This book focuses on all aspects of pancreatic pathology, from key features of benign and malignant lesions to diagnostic pearls for differential diagnosis of encountered entities in pancreatobiliary fine needle aspirations and small biopsies. Chapters include a brief introduction and a practical approach to diagnose benign and malignant lesions. The key cytomorphologic features and main differential diagnoses are also summarized in concise tables. Richly colored images complement the text and represent key findings pertaining to the text discussion. An important and current chapter on molecular testing proves to be very useful for the readership for their daily practice in this era of targeted therapy. Written by experts in the fields, all authors contribute their collective experience of preeminent cytopathology service spanning a long time span. Pancreas and Biliary Tract Cytohistology serves as a practical resource for cytotechnologists, cytopathologists and pathologists who are practicing cytopathology and rendering diagnoses on small biopsy samples on pancreatic lesions.

Contents:
Intro; Preface; Contents; Editors; Contributors;
1: Indications and Techniques of Fine-Needle Aspiration of the Pancreas; Introduction; Diagnostic EUS; EUS-FNA; EUS-FNA Techniques; Position and Number of Passes; Needle Choice; Histology and Fine-Needle Biopsy; Suction; Stylet; On-Site Cytopathology; Complementary Techniques; Summary; References;
2: Reporting of Pancreatico-biliary Cytopathology; Diagnostic Categories; Nondiagnostic; Negative; Atypical; Neoplastic; Neoplastic: Benign; Neoplastic: Other; Suspicious for Malignancy; Positive/Malignant; Risk of Malignancy Impact of Pap Society GuidelinesReferences;
3: Cytology of Normal Pancreas; Introduction and Approach to Pancreaticobiliary Fine-Needle Aspiration; Anatomy and Embryology of Pancreas; Cytology of Normal Pancreas; Benign Ductal Cells; Important Cytologic Features; Histologic Correlation; Differential Diagnosis and Pitfalls; Benign Acinar Cells; Important Cytologic Features; Histologic Correlation; Differential Diagnosis and Pitfalls; Islet Cells; Important Cytologic Features; Histologic Correlation; Differential Diagnosis and Pitfalls; Contamination; Important Cytologic Features Benign Duodenal EpitheliumBenign Gastric Epithelium; Benign Mesothelial Cells; Benign Hepatocytes; Differential Diagnosis and Pitfalls; Approach to Pancreatic EUS-FNA Cytology; References;
4: Nonneoplastic Solid Mass Lesions of the Pancreas; Introduction; Chronic Pancreatitis; Background; Imaging and Gross Findings; Key Cytomorphologic Features; Key Histologic Features; Differential Diagnosis; Autoimmune Pancreatitis; Background; Imaging and Gross Findings; Key Cytomorphologic Features; Key Histologic Features; Differential Diagnosis; Paraduodenal Groove Pancreatitis; Background Imaging and Gross FindingsKey Cytomorphologic Features; Key Histologic Features; Intrapancreatic Accessory Spleen; Background; Imaging and Gross Findings; Key Cytologic Features; Histologic Features; Differential Diagnosis; Intrapancreatic Reactive Lymph Node; Key Cytomorphologic Features; Sarcoidosis; Background; Key Cytologic Features; Histologic Features; References;
5: Pancreatic Ductal Adenocarcinoma and Its Variants; Introduction and Clinical Presentation; Radiographic Features and Fine Needle Aspiration; Pancreatic Cancer Precursors: Pancreatic Intraepithelial Neoplasia (PanIN) Important Cytologic FeaturesHistologic Correlation; Differential Diagnosis (Cytology and Histology); Ancillary Testing and Molecular Signature; Ductal Adenocarcinoma, Conventional Type; Important Cytologic Features; Well-Differentiated PDCA; High-Grade PDCA; Histologic Correlation; Differential Diagnosis; Ancillary Testing and Molecular Signature; Undifferentiated (Anaplastic) Carcinoma; Important Cytologic Features and Histologic Correlation; Differential Diagnosis; Ancillary Testing and Molecular Signature; Undifferentiated Carcinoma with Osteoclast-Like Giant Cells

Summary: This book is the first to provide a thorough overview of the experience of pancreas transplantation in Asian countries, including in particular Korea, Taiwan, and Japan. Recent trends are identified and attention drawn to differences in comparison with the United States and Europe. Such differences relate, for example, to the history of pancreas transplantation, the operative procedure, and the organ-sharing system. In addition, the insulin-secreting ability of pancreatic islet cells is thought to vary depending on race. Beyond these aspects, the coverage also encompasses ABO-incompatible living donor pancreas transplantation, which is very rarely performed elsewhere in the world. By introducing the number, technique, and outcomes of pancreas transplantation in Asian countries, the book will hopefully further stimulate the pancreas transplantation program in this region and beyond. It will be of value for all medical professionals in the field and will be informative for diabetic patients receiving insulin treatment in Asia.

Contents:
1. Introduction
2. History of pancreas transplantation.-a. General/Japan/Korea/Taiwan
3. Indication of pancreas transplantation(Donor and Recipient)
a. General/Japan/Korea/Taiwan
4. Pre operative evaluation
a. General/Japan/Korea/Taiwan
5. Surgical aspect of pancreas transplantation
a. General/Japan/Korea/Taiwan
6. Post operative management(general care,immunosuppressant, graft monitoring etc)
a. General/Japan/Korea/Taiwan
7. Outcomes
a. General/Japan/Korea/Taiwan
8. Complication
a. General/Japan/Korea/Taiwan
9. Conclusion.

Summary: "New in the Differential Diagnosis in Surgical Pathology series, this abundantly illustrated title helps you systematically solve tough diagnostic challenges in pancreatic and biliary pathology. It uses select images of clinical and pathological findings, together with succinct, expert instructions and diagnostic pearls, to guide you through the decision-making process. By presenting material according to the way pathologists actually work, this user-friendly volume helps you quickly differentiate commonly confused entities that have overlapping morphologic features. Presents nearly 100 differential diagnoses in pancreatic and biliary pathology, including the most common entities as well as selected rare diseases. Provides concise, bulleted summaries of clinical and pathological findings and relevant pictorial examples on the corresponding pages. Features 1,000 high-quality, full-color images of similar-looking lesions side by side for easy comparison with respect to clinicopathologic features and ancillary tests. Includes more than 30 detailed chapters on the pancreas, as well as coverage of the ampulla, extrahepatic bile duct, and gallbladder. Ideal for practicing pathologists, pathologists in training, residents, and medical students"-- Provided by publisher.

Summary: In organizing the second edition of this renowned Handbook, Dr. Neoptolemos and his co-editors have produced and updated a revised edition to the distinguished Major Reference Work devoted to pancreatic cancer. Like its preceding edition, the second edition continues to have a widespread appeal among clinicians, pathologists and basic scientists, who are now struggling to understand this complex and rapidly expanding field. Because of the recent and vast growth in both the clinical and scientific research being done in pancreatic cancer, (there is currently an unprecedented investment by academia and industry in this field), each research's knowledge of other specialty areas outside his or her own is often quite limited. The aim of the new edition is to place the tangible advances, including new developments in surgical approaches with regards to resection techniques, the state of laparoscopic approaches, the growing impact of surgical approaches in the management of recurrent pancreatic cancer, controversies in the management of IMPN as the precursor lesion for PDAC and others - readily at hand. The second edition focuses on advances that will not become dated, and the editors have chosen authors, who are the very best in each area.

Contents:
Section: The Nature of Pancreatic Cancer
Cell Cycle Machinery and Its Alterations in Pancreatic Cancer
Animal modelling of Pancreatitis-to-Cancer Progression
Stromal Inflammation in Pancreatic Cancer: Mechanisms and Translational Applications
Familial Pancreatic Cancer
Section: Clinical Management of Pancreatic Cancer
Therapeutic Endoscopy in the Management of Pancreatic Cancer
Controversies in Pathology Reporting and Staging
Staging and Postoperative Outcomes Using the International Study Group of Pancreatic Surgery (ISGPS) Classifications
Borderline Respectable Pancreatic Cancer
New Japanese Classification of Pancreatic Cancer
Arterial Resection in Pancreatic Cancer
Treatment of Recurrent Pancreatic Cancer After Surgery
Neoadjuvant Chemotherapy in Pancreatic Cancer
Differential Therapy Based on Tumor Heterogeneity in Pancreatic Cancer
Neoadjuvant Chemoradiation for Operable Pancreatic Cancer: the Importance of Local Disease Control
Section: New Directions
Development of Novel Therapeutic Response Biomarkers
Clinical Applications of Genomics and Proteomics in Pancreatic Cancer
Approaching Pancreatic Cancer Phenotypes via Metabolomics
Circulating Tumour Cells
Cancer Exosomes for Early Pancreatic Cancer Diagnosis and Role Metastasis
Metabolism in Pancreatic Cancer
Secondary Screening for Inherited Pancreatic Ductal Adenocarcinoma
Role of Radiotherapy in Locally Advanced Pancreatic Cancer
Evolution of Pancreatic Cancer Surgery
Multiparameter Modalities for the Study of Patients in the Setting of Individualized Medicine
Epigenetic Pharmacology
Precision Medicine Based on Next Generation Sequencing and Master Controllers.

Summary: This book provides a comprehensive, state-of-the-art overview of pancreatic cancer. The text presents new data about risk factors and genetic predisposition for pancreatic cancer, highlights current screening strategies and preliminary results, and reviews diagnosis and staging of pancreatic cancer, with a focus on imaging evaluations, laparoscopy, endoscopic ultrasound-guided biopsies, and biomarkers. The book also spotlights emerging paradigms in pancreatic cancer management, such as minimally invasive surgical approaches and emerging radiation approaches, and provides valuable insight into the role of nutrition and early integration of supportive/palliative care for pancreatic cancer patients. Written by experts in the field, Pancreatic Cancer: A Multidisciplinary Approach is an invaluable resource for physicians and researchers with an interest in pancreatic cancer.

Contents:
Pancreatic Cancer at a Glance
Risk Factors and Genetic Predisposition
Pancreatic Cancer and Diabetes Mellitus
Pancreatic Cancer Screening
Diagnosis and Staging of Pancreatic Cancer
Imaging Evaluations: Pancreatic Protocol CT and MRI, PET-CT
Laparoscopy
Role of Gastroenterologists: Endoscopic Ultrasound (EUS), EUS-guided Biopsy
Role of Ca 19-9 in Diagnosis/Staging and Management
Management of Locally Advanced/ Metastatic Disease
Medical Oncology
Radiation Oncology
Management of Resectable and Borderline Resectable Disease
Surgery
Medical Oncology
Radiation Oncology
Endoscopic Management of Pancreatic Cancer Symptoms
Jaundice/Biliary Obstruction: ERCP/EUS BD
Gastric Outlet Obstruction: Antroduodenal Stenting, Venting PEG, EUS-guided Gastrojejunostomy
Pain Control: Celiac Plexus Neurolysis
Emerging Paradigms in Pancreatic Cancer
Minimally Invasive Surgical Approaches
EUS-Guided Local Therapies
Imaging Based Biomarkers for Pancreatic Cancer
Liquid Biopsies in Pancreatic Cancer
Molecular Profiling and Precision Medicine for Pancreatic Cancer
The Prospects of Immunotherapy in Pancreatic Cancer
Microbiome in Pancreatic Cancer
Early Drug Development in Pancreatic Cancer
Mechanisms and Evidence on Pancreatic Cancer Prevention
Nutrition in Pancreatic Cancer
Prioritizing the Patient Experience: Early Integration of Supportive/Palliative Care in Pancreatic Cancer Management
Patient Reported Outcomes and Quality of Life
Alternative/Integrative Medicine in Pancreatic Cancer. .

Summary: This book provides state of the art knowledge on a broad range of clinical issues in pancreatic cancer, covering topics from screening and pathophysiology to surgical treatments. In particular, the focus is on current controversies and on evidence-based surgical techniques. Further aspects considered include the management of precancerous lesions, diagnostic methods, perioperative care and nonsurgical treatment. The description of surgical methods is supported by many helpful illustrations and important technical issues are carefully addressed. Determination of resectability and extent of surgery is also discussed. Based on recent developments in surgical techniques, some surgeons are performing more and more radical operations. It is essential, however, that surgical strategy is based on the best available evidence and surgeons will find that this book offers valuable help in achieving this aim. In addition, it will be a great asset in clinical practice for all who are involved or interested in the management of pancreatic cancer.

Summary: This book provides a thorough overview of the detection of PCNs using modern imaging techniques and a clear guide to the recognition of the different subtypes of PCN based on their radiologic and histopathologic features. This volume will serve as an excellent aid to the selection of optimal therapeutic strategies based on preoperative diagnosis. A further important feature is the emphasis placed on radiologic, clinical, and surgical correlations. Pancreatic cystic neoplasms (PCNs) have been increasingly recognized during the past decade, mainly because of the widespread use of modern imaging modalities for the investigation of often unrelated abdominal symptoms. The three most common subtypes of PCN are serous cystic neoplasms, mucinous cystic neoplasms, and intraductal papillary mucinous neoplasms. These subtypes have distinct radiologic and histopathological features, and their biological behavior differs greatly. Accurate preoperative diagnosis is of prime importance in selecting the optimal therapeutic strategy: while serous cystic neoplasms are almost always benign, and may be treated conservatively, mucinous cystic neoplasms and intraductal papillary mucinous neoplasms have malignant potential, warranting an aggressive surgical approach, i.e., pancreatectomy. Pancreatic Cystic Neoplasms will be of great interest to surgeons, gastroenterologists, radiologists, oncologists, and pathologists, and also to internists and residents in these specialties.

Contents:
Introduction
Classification
Serous cystic neoplasms
Mucinous cystic neoplasms
Intraductal Papillary Mucinous Neoplasms
Rare cystic neoplasms
Diagnostic evaluation
Imaging
Cross sectional Imaging
US, CT, MRI
Endoscopic ultrasonography
ERCP / MRCP
Intraductal ultrasonography / ductoscopy
FNA and analysis of the cystic fluid
Cytology
Biochemical analysis
Treatment
Indications for surgery
Surgical treatment
Adjuvant therapy
Follow-up
Prognosis.

Contents:
Historical Background of Pancreatic Islet Isolation / Miriam Ramírez-Domínguez
The Different Faces of the Pancreatic Islets / Midhat H.Abdulreda, Rayner Rodriguez-Diaz, Over Cabrera, Alejandro Caicedo, Per-Olof Berggren
Isolation of Mouse Pancreatic Islets of Langerhans / Miriam Ramírez-Domínguez
Pancreatic Islets: Methods for Isolation and Purification of Juvenile and Adult Pig Islets / Heide Brandhorst, Paul R.V. Johnson, Daniel Brandhorst
Isolation of Pancreatic Islets from NonHuman Primates / Dora M. Berman
Necessities for a Clinical Islet Program / Wayne John Hawthorne
Clinical Islet Isolation / Wayne John Hawthorne, Lindy Jane Williams, Yi Vee Chew
Index.

Contents:
Classification of Pancreatic Lesions
Pancreatic Adenocarcinoma
Less Common Solid Tumors of Pancreas
Cystic Lesions of the Pancreas
Autoimmune pancreatitis
Pancreatitis-related pancreatic masses: Chronic Pancreatitis
Radiographic imaging
EUS Imaging in the Diagnosis of Pancreatic Masses
Contrast-enhanced EUS
Endoscopic Ultrasonography: Role of EUS Sampling in Solid Pancreas Lesions
Endoscopic Ultrasonography: Role of EUS sampling in Cystic lesions
Role of ERCP in Diagnosing Pancreatic Masses
Endoscopic Retrograde Cholangiopancreatography (ERCP): Pancreatoscopy for the evaluation of pancreatic neoplasia
Recent Advances in Cytologic and Histologic Specimen Evaluation, FISH and Molecular Markers
Evaluation and Surveillance Strategies for Patients at Increased Risk of Pancreatic Cancer
Differential Diagnosis and Diagnostic Evaluation Algorithm
Surgery for Solid Pancreatic Neoplasms
Radiation Therapy for Pancreatic Cancer
Chemotherapy
Endoscopic therapy: ERCP based therapy
Endoscopic therapy: EUS-based therapy
Endoscopic Therapy of Gastric Outlet Obstruction
Management of Cystic Lesions of the Pancreas
Recent Advances and Novel Treatments of Pancreatic Masses.

Summary: "This book provides a comprehensive review of entities that may be encountered in pancreatic cytology. It is designed for cytotechnologists, pathology trainees, pathologists, and cytopathologists. It is also a useful guide for advanced endoscopists performing EUS-guided FNA, and surgeons and oncologists treating patients with pancreatic disease wanting to understand their pathology reports"-- Provided by publisher.

Contents:
Introduction to pancreatic pathology and fine-needle aspiration cytology / Dhillon, J.
Processing of fine-needle aspiration specimens from pancreatic lesions / Dhillon, J.
Imaging of pancreatic tumors / Morse, B., Klapman, J.
Normal components and contaminants / Dhillon, J.
Non-neoplastic masses of the pancreas / Centeno, B.A., Thomas, S.
Non-neoplastic and neoplastic cysts of the pancreas / Centeno, B.A., Thomas, S.
Pancreatic ductal adenocarcinoma / Betancourt, M., Dhillon, J.
Non-ductal tumors of the pancreas / Dhillon, J.
Metastases, secondary tumors, and lymphomas of the pancreas / Centeno, B.A.
Mesenchymal tumors of the pancreas / Dhillon, J.

Summary: From embryology to epidemiology, pathophysiology, diagnosis, complications, treatment and prognosis, this book provides a comprehensive overview and the latest evidence-based data on pancreaticobiliary maljunction (PBM), a congenital malformation in which the pancreatic and bile ducts join anatomically outside the duodenal wall. Resulting in various pathologic conditions, such as biliary cancer and pancreatitis, immediate prophylactic surgery is recommended upon diagnosis. The standard operative procedure for congenital biliary dilatation (CBD) is extrahepatic bile duct resection with bilioenteric anastomosis, but the optimal treatment of adult patients with PBM without biliary dilatation remains highly debatable. This book, written by pioneering editors and authors provides latest data, sheds new light on the disease. With abundant figures to aid understanding, Pancreaticobiliary Maljunction and Congenital Biliary Dilatation appeals to a wide readership, especially adult and pediatric surgeons, physicians including gastroenterologists and endoscopists, as well as radiologists and pathologists.

Contents:
Epidemiology and genetics of pancreatitis / David C Whitcomb
Pathobiology of the acinar cell in acute pancreatitis / Stephen J Pandol
Locoregional pathophysiology in acute pancreatitis: pancreas and intestine / Alistair BJ Escott, Anthony J Phillips, John A Windsor
Pathophysiology of systemic inflammatory response syndrome and multiorgan dysfunction syndrome in acute pancreatitis / Pramod Kumar Garg
Diagnosis, prediction, and classification / Efstratios Koutroumpakis, Georgios I Papachristou
Medical treatment / Andree H Koop, Timothy B Gardner
Nutritional treatment in acute pancreatitis / Maxim S Petrov
Gallstone pancreatitis: diagnosis and treatment / Marsela Sina, Gregory A Coté
Treatment of local complications / Stefan AW Bouwense, Thomas L Bollen, Paul Fockens, Marc GH Besselink for the Dutch Pancreatitis Study Group
Treatment of systemic complications and organ failure / Alexsander K Bressan, Chad G Ball
Specific treatment for acute pancreatitis / Li Wen, Muhammad A Javed, Kiran Altaf, Peter Szatmary, Robert Sutton
Sequelae of acute pancreatitis / Nicholas J Zyromski, Lucas McDuffie
History of chronic pancreatitis / Peter A Banks
Epidemiology and pathophysiology: epidemiology and risk factors / Dhiraj Yadav, Julia Greer
Epidemiology and pathophysiology: genetic insights into pathogenesis / David C Whitcomb
Pancreatic stellate cells: what do they tell us about chronic pancreatitis? / Minoti V Apte, Zhihong Xu, Ron C Pirola, Jeremy S Wilson
Autoimmune pancreatitis: an update / Thiruvengadam Muniraj, Raghuwansh P Sah, Suresh T Chari
Etiology and pathophysiology: tropical pancreatitis / Rajesh Gupta, Sunil D Shenvi, Ritambhra Nada, Surinder S Rana, Deepak Bhasin
Mechanisms and pathways of pain in chronic pancreatitis / Dana A Dominguez, Kimberly S Kirkwood
Imaging of chronic pancreatitis / Ferenc Czeyda-Pommersheim, Bobby Kalb, Diego Martin
Endoscopic ultrasonography in chronic pancreatitis / Brenda Hoffman, Nathaniel Ranney
Pancreatic enzyme replacement therapy (PERT) / Ravi K Prakash, Alexander Schlachterman, Chris E Forsmark
Nutritional treatment: antioxidant treatment / Ajith K Siriwardena
Pancreatogenic diabetes: etiology, implications, and management / Dana K Andersen
Nutrition without a pancreas: how does the gut do it? / William Lancaster, Matthew Kappus, Robert Martindale
Endoscopic management of chronic pancreatitis / Wiriyaporn Ridtitid, Stuart Sherman
Shocking and fragmenting pancreatic ductal stones / Rupjyoti Talukdar, Duvvur Nageshwar Reddy
Endoscopic management: celiac plexus blockade / Vikesh K Singh
A brief history of modern surgery for chronic pancreatitis / Michael G Sarr, Charles F Frey, Thomas Schnelldorfer
Surgery for chronic pancreatitis: indications and timing of surgery / Philippus C Bornman, Dirk J Gouma, Jake E J Krige
Chronic pancreatitis: surgical strategy in complicated diseases / Philippus C Bornman, Jake E J Krige, Sandie R Thomson
Surgery for chronic pancreatitis: pancreatic duct drainage procedures / Dirk J Gouma, Philippus C Bornman
Surgical management: resection and drainage procedures / Tobias Keck, Ulrich Wellner, Ulrich Adam
The role of pancreatoduodenectomy in the management of chronic pancreatitis / Kristopher P Croome, Michael B Farnell
Total pancreatectomy and islet cell autotransplantation: patient selection / Sydne Muratore, Martin Freeman, Greg Beilman
Total pancreatectomy and islet cell autotransplantation: the science of islet cell preservation, from pancreas to liver / Appakalai N Balamurugan, Melena D Bellin
Total pancreatectomy and islet cell autotransplantation: long-term assessment of graft function / Giuseppe Garcea, Ashley Dennison.

Summary: This clinical casebook provides a comprehensive yet concise state-of-the-art review of pancreatic disease. Presented in a case-based format, each case focuses on a different varient of pancreatic disease and pancreatic cancer, with sections on diagnosis and early detection, management of the disease, and treatment of complications from the disease. The role of neoadjuvant therapy for pancreatic cancer and emerging treatment algorithms for chronic pancreatitis are also highlighted in the text. Written by experts in the field, Pancreatology: A Clinical Casebook is a valuable resource for clinicians, surgeons, and researchers interested in caring for patients with pancreatic disease.

Summary: "The COVID-19 pandemic has led to a host of critical reflections about discourse practises dealing with public health issues. Situating crisis communication at the centre of societal and political debates about responses to the pandemic, this volume analyses the discursive strategies used in a variety of settings. Exploring how crisis discourse has become a part of managing the public health crisis itself, this book focuses on the communicative tasks and challenges for both speakers and their public audiences in seven areas: - establishment of discursive and political authority - official governmental and expert communication to the public - public understanding of government communication - legitimation of public health management as a 'war' - judging and blaming a collective other - cross-national comparison and rivalry - empathy and encouragement Covering global discourses from Asia, Europe, the Middle East, North and South America, and New Zealand, chapters use corpus-based data to cast light on these issues from a variety of languages. With crisis discourse already the object of fierce national and international debates about the appropriateness of specific communicative styles, information management and 'verbal hygiene', Pandemic and Crisis Discourse offers an authoritative intervention from language experts"-- Provided by publisher.

Contents:
List of Figures
List of Tables
List of Contributors
Introduction, Andreas Musolff, Ruth Breeze, Kayo Kondo and Sara Vilar-Lluch
Part I: The Discourse of Authority in a Global Crisis: Who Defines (If There Is) a Pandemic?
1 COVID-19 Press Conferences Across Time: World Health Organization vs. Chinese Ministry of Foreign Affairs, Dennis Tay
2 Exploring the Multimodal Representation of COVID-19 on the Official Homepage of World Health Organization (WHO): A Social-Semiotic Approach, Amir H. Y. Salama
3 COVID-19 Representations in Political Statements: A Corpus-Driven Analysis, Alexandra Papamanoli and Themis P. Kaniklidou
4 How Autocrats Cope with the Corona Challenge: Belarus vs. Russia, Daniel Weiss
5 Counting Coronavirus: Mathematical Language in The UK Response to Covid-19, Lee Jarvis
Part II: The Discourse of Crisis Management: How is the Public Meant to and How Does it Understand the Pandemic?
6 "Coronavirus Explainers" for Public Communication of Science: Everything the Public Needs to Know, María José Luzón
7 'COVID Warriors: An Analysis of the Use of Metaphors in Children's Books to Help them Understand Covid-19, María Muelas-Gil
8 Corona in the Linguistic Landscape, Neele Mundt and Frank Polzenhagen
9 Political Comedy and the Challenges of Public Communication during the Covid-19 Crisis: A Corpus-Based Study of Last Week Tonight's Coverage of the Pandemic, Virginia Zorzi
10 Social Reaction to a New Health Threat: The Perception of the COVID-19 Health Crisis by British and Spanish Readerships, Sara Vilar-Lluch
11 How to Pass this Exam? Dealing with COVID-19 through Metaphors in Turkish Online Public Discourse, Melike Bas and Esranur Efeoglu-Özcan
Part III: The Discourse of 'War' against the Pandemic: How to 'Fight' COVID-19?
12 When Wars are Good: Emotional Unpacking Anti-Coronavirus Measures, Molly Xie Pan and Joanna Zhuoan Chen
13 Legitimising a Global Fight for a Shared Future: A Critical Metaphor Analysis of the Reportage of COVID-19 in China Daily, Yating Yu. 14 Metaphoric Framings of Fighting COVID-19, Mariana Neagu
15 From an Invisible Enemy to a Football Match with the Virus: Adjusting the COVID-19 Pandemic Metaphors to Political Agendas in Serbian Public Discourse, Nadežda Silaški and Tatjana Đurovic
16 Are Health Care Political Responses Gendered? A Case Study, Fabienne Baider and Maria Constantinou
17 "War against COVID-19": Is the Pandemic as War Metaphor Helpful or Hurtful?, Andreas Musolff
Part IV: The Discourse of Judgement and Rivalry: Blaming Other/s for the Pandemic and Comparing National Performances
18 "Chinese Virus": A Multimodal Critical Discourse Analysis of U.S. Government Communication about COVID-19 and its Impact on Chinese and Asian Americans in the U.S., Peiwen Wang and Theresa Catalano
19 'Those Lunatic Zombies': The Discursive Framing of Wuhan Lockdown Escapees in Digital Space, Janet Ho and Emily Chiang
20 Identity as Crime: How Indian Media's Coverage Demonised Muslims as Coronavirus Spreader, Aaquib Khan
21 Media Discourse in Slovenia and in the Slovenian-Italian Cross-Border Area during the COVID-19 Pandemic, Vesna Mikolic
Part V: The Discourse of Empathy and Encouragement: How to Foster Solidarity among Doctors, Patients and Health Experts
22 Agency in End-of-Life Conversations during the COVID-19 Pandemic, Dariusz Galasinski and Justyna Ziólkowska
23 Doctors' Empathy and Compassion in Online Health Consultations during the COVID-19 Pandemic in Japan, Kayo Kondo
24 "Masks aren't Comfortable or Sexy, but...": Exploring Identity Work on Dr Mike's Instagram during the First Phase of the COVID-19 Pandemic, Kim Schoofs, Dorien Van De Mieroop, Stephanie Schnurr, Haiyan Huang and Anastasia Stavridou
25 Choosing to Stay Fit? Glocalized Ideologies of Health and Fitness during a Pandemic, Ulrike Vogl, Geert Jacobs, Karin Andersson and Jesper Andreasson
26 Unite against COVID-19: Jacinda Ardern's Discursive Approach to the Pandemic, Marta Degani
Index.

Summary: This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The books respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.

Contents:
Part 1: Genomic diversity and the pan-genome concept
Chapter 1: The pan-genome: a data-drivendiscovery in biology
Chapter 2: The prokaryotic species concept and challenges
Chapter 3: Bacterial guide on how to design a diversified gene portfolio
Chapter 4: A review of pan-genome tools and recent studies
Part 2: Evolutionary biology of pan-genomes
Chapter 5: Structure and dynamics of bacterial populations: pan-genome ecology
Chapter 6: Bacterial microevolution and the pan-genome
Chapter 7: Pan-genomes and selection: the public goods hypothesis
Chapter 8: A pan-genomic perspective on the emergence, maintenance and predictability of antibiotic resistance
Part 3: Pan-genomics: an open, evolving discipline
Chapter 9: Metapangenome: at the crossroad of pangenomics and metagenomics
Chapter 10: Pan-genome flux balance analysis towards pan-phenomes
Chapter 11: Bacterial epigenomics: epigenetics in the age of population genomics
Chapter 12: Eukaryotic pan-genomes
Chapter 13: Computational strategies for eukaryotic pan-genome analyses.

Contents:
Part I Introduction
Why is statistics such a fascinating subject?
How statistics differs from mathematics
Statistical literacy- essential in the 21st century
Statistical inquiry on the web
Part II Statistical description
Trustworthy statistics are accurate, meaningful and relevant
Let's hear it for the standard deviation!
Index numbers- time travel for averages
The beguiling ways of bad statistics I
The beguiling ways of bad statistics II
Part III Preliminaries to inference
Puzzles and paradoxes in probability
Some paradoxes of randomness
Hidden risks for gamblers
Models in statistics
The normal distribution: history, computation and curiosities
Part IV Statistical inference
The pillars of applied statistics- estimation
The pillars of applied statistics- hypothesis testing
'Data snooping' and the significance level in multiple testing
Francis Galton and the birth of regression
Experimental design- piercing the veil of random variation
In praise of Bayes
Part V Some statistical byways
Quality in statistics
History of ideas: statistical personalities and the personalities of statisticians
Statistical eponymy
Statistical 'laws'
Statistical artefacts
Part VI Answers
Answers to the chapter questions.

Summary: Vascular management and care has become a truly multidisciplinary enterprise. As a result of scientific progress, the number of specialists involved in the treatment of patients with vascular diseases is steadily increasing. While in the past, treatments were delivered by individual specialists, in the twenty-first century a team approach is without doubt the most effective strategy. Depending on the clinical manifestations, cardiologists, cardiac surgeons, vascular specialists, angiologists, radiologists, vascular surgeons, neurologists, neurointerventionalists, lipidologists, blood coagulation specialists, and diabetologists, to name but a few, may be involved. In order to promote professional excellence in this dynamic and rapidly evolving field, a shared knowledge base and interdisciplinary standards need to be established. PanVascular Medicine, 2nd edition℗ℓhas been designed to offer such an interdisciplinary platform, providing vascular specialists with state-of-the-art descriptive and procedural knowledge. Basic science, diagnostics, and therapy are all comprehensively covered. In a series of succinct, clearly written chapters, renowned specialists introduce and comment on the current international guidelines and present up-to-date reviews of all aspects of vascular care.℗ℓ℗ℓ℗ℓ℗ℓ℗ℓ

Contents:
Knowledge and Skills
PanVascular domain
Vascular Biology, Molecular Biology and Genetics
Clinical Vascular Physiology and Pathophysiology
Prevention
Vascular Diagnosis
X-ray Angiography and Venography
Epidemiology and Risk Factors
Nosology
Coronary Artery Disease
Cerebrovascular Disease
Peripheral Artery Disease
Vascular Disease of the Lungs
Vascular Disease of the Gastrointestinal Tract
Renovascular Disease
Urogenital Vascular Disease
Peripheral Venous Disease
Vascular Pharmacology
Catheter-based and Surgery-related Management Instrumentation
Access, Hemostasis
Coronary ? Interventional
Coronary: Surgery
Cerebrovascular ? Interventional
Cerebrovascular: Interventional
Aortic: Interventional Surgery
Aortic, Visceral: Interventional
Aortic, Visceral: Surgery
Peripheral, Arterial
Interventional
Peripheral, Arterial ? Surgery
Peripheral, Venous . Interventional and Surgery.

Contents:
Overview of Diagnostic Terminology and Reporting
Category I: Non-Diagnostic
Category II: Negative (for Malignancy)
Category III: Atypical
Category IV: Neoplastic-Benign
Category IV: Neoplastic-Other
Category V: Suspicious (for Malignancy)
Category VI: Positive or Malignant
Appendix A: Template for Cyst Diagnosis
Appendix B: Mucinous Etiology
Appendix C: Useful Ancillary Tests.

Summary: This volume provides an overview of the recent advances in the field of paper microfluidics, whose innumerable research domains have stimulated considerable efforts to the development of rapid, cost-effective and simplified point-of-care diagnostic systems. The book is divided into three parts viz. theoretical background of paper microfluidics, fabrication techniques for paper-based devices, and broad applications. Each chapter of the book is self-explanatory and focuses on a specific topic and its relation to paper microfluidics and starts with a brief description of the topics physical background, essential definitions, and a short story of the recent progress in the relevant field. The book also covers the future outlook, remaining challenges, and emerging opportunities. This book shall be a tremendous up-to-date resource for researchers working in the area globally.

Contents:
Intro; Preface; Contents; About the Editors; 1 A Historical Perspective on Paper Microfluidic Based Point-of-Care Diagnostics; Abstract; 1.1 Introduction; 1.2 Paper Microfluidics: Historical Perspective; 1.3 Outline; References; 2 Fluid Transport Mechanisms in Paper-Based Microfluidic Devices; Abstract; 2.1 Introduction; 2.2 Fluid Transport; 2.2.1 Classical Lucas-Washburn Equation (Capillary Flow); 2.2.2 Darcy's Law for Fluid Flow; 2.2.3 Fluid Transport in the Porous Media of Varying Cross Section/Arbitrary Shape; 2.2.4 Radial Fluid Transport in Porous Media 2.2.5 Diffusion-Based Fluid Transport; 2.2.6 Lateral Flow Immunoassay (LFIA); 2.3 Summary; References; 3 Fabrication Techniques for Paper-Based Microfluidic Devices; Abstract; 3.1 Introduction; 3.2 Fabrication Methods; 3.2.1 2D Fabrication Methods; 3.2.2 Flexographic Printing; 3.2.3 3D Fabrication Methods; 3.3 Comparison of Various Fabrication Methods; References; 4 Flow Control in Paper-Based Microfluidic Devices; Abstract; 4.1 Introduction; 4.2 Fluid Flow Through Porous Substrates; 4.2.1 Lucas-Washburn Equation; 4.2.2 Darcy's Equation for Fluid Flow 4.2.3 Richard's Equation for Partially Saturated Flows; 4.3 Controlling the Fluid Flow in Paperfluidic Devices; 4.3.1 Techniques to Achieve Flow Control Without Valves; 4.3.1.1 Changing the Channel Dimensions; 4.3.1.2 Creation of Alternate Flow Paths; 4.3.1.3 Changing the Surface Wettability; 4.3.1.4 Changing the Properties of the Porous Substrate; 4.3.1.5 Increasing the Resistance to Fluid Flow Using Physicochemical Barriers; 4.3.1.6 Electrostatic Interactions Between Device Components; 4.3.1.7 Varying the Channel Dimensions for Specific Introduction of Reagents 4.3.2 Techniques to Achieve Flow Control Utilizing Valve-Like Tools; 4.3.2.1 Dissolvable Species; 4.3.2.2 Mechanical Tools Which Connect or Disconnect Channels; 4.3.2.3 Wax-Based Valves; 4.3.2.4 Fluidic Diodes; 4.3.2.5 Automatically Actuated External Valves; 4.4 Challenges to Translation of Flow Control-Based Paperfluidic Devices; References; 5 Paper Microfluidic Based Device for Blood/Plasma Separation; Abstract; 5.1 Introduction; 5.2 Physiological Hemodynamics and Porous Media Hemodynamics; 5.3 Recent Advances in Paper Based Blood Plasma Separation Devices; 5.4 Summary and Future Perspectives

Contents:

v. 1. The Polyomaviruses.

Summary: The Paracellular Channel: Biology, Physiology and Disease serves as the first volume to offer a cohesive and unifying picture of the critical functions of paracellular channels (tight junctions) in different tissues. This new class of ion channel utilizes a completely different mechanism to create ion passage pathways across the cell junction. This volume outlines common principles that govern the organization and regulation of these diverse cellular structures, describes the methodology of study, and highlights the pathophysiologic consequence of abnormal structure and functions of the paracellular channels in human diseases. Coverage includes biochemical, biophysical, structural, physiologic analyses of the paracellular channel, and new technologies for recording and characterization.

Contents:
Introduction
Paracellular channel formation
Paracellular channel recording
Paracellular cation channel
Paracellular anion channel
Paracellular water channel
Paracellular channel in organ system
Paracellular channel in human disease
Paracellular channel as drug target
Paracellular channel evolution
Perspective.

Contents:
Monotargeting versus multitargeting
The Pleiotropic pharmacology of plant polyphenols
Primary prevention of Alzheimer's disease
Secondary prevention of Alzheimer's disease
Treatment mechanisms in mild to moderate Alzheimer's disease
Pleiotropic theory
Dose-adherence and intent-to-treat.

Summary: This book presents paraproteinemia and the highly complex scientific information behind it to clinicians in a way they can understand and, ultimately, apply to their diagnostic and treatment practices. Paraproteinemia or dysproteinemia is characterized by the overproduction of an immunoglobulin by clonal expansion of cells from the B cells lineage which includes the plasma cells. The resultant monoclonal protein can be composed of the entire immunoglobulin or of its components. The identification and categorization of the different representatives of this group of disorders have traveled a long distance, but despite its high prevalence there is surprisingly limited evidence, in some areas, to guide the best clinical practice both at the time of diagnosis and during follow up. This book seeks to fill that gap. The book is divided into three sections, introductory chapters, disease entities and experimental therapies. The text guides clinicians through these diseases and disorders. The group of renal diseases attributed to deposition of monoclonal immunoglobulins or their components are arranged as one disease category in order to simplify the understanding of these complicated diseases in plasma cell dysplasia. In emulation of this practical approach, at a larger scale, the volume editors and chapter authors attempt to encompass the whole spectrum of the paraproteinemias in this text. This will have the dual benefit of offering the audience a panoramic view of this group of disorders and simultaneously keeping them focused on its individual representatives. There have been many recent advances in diagnosis, risk stratifications, and management of many members of this group of diseases and they are explored in depth here. This is an ideal guide for rheumatologists, hematologists, nephrologists, immunologists, oncologists, and relevant trainees caring for patients with paraproteinemia and related disorders.

Contents:
The phenomenon of Paraproteinemia
B Cell in Health and Disease
Immunoglobulins, structure and function
The Bone marrow as a hotbed for Plasma Cell activation
Animal Models in Monoclonal Immunoglobulin Related Diseases
An Approach to The Diagnosis of Paraproteinemia
Amyloidosis: Pathogenesis, types and diagnosis
Amyloidosis: Clinical Manifestations and Treatment
Primary Light Chain (AL) Amyloidosis
Monoclonal Immunoglobulin Deposition Disease
Multiple Myeloma
Monoclonal Gammopathy of Undetermined Significance (MGUS) & Highlight on Monoclonal Gammopathy of Neurological Significance (MGNS)
Monoclonal Gammopathy of Renal Significance: An Insight
Waldenstrom Macroglobulinemia
IgG4 Related Disease Overview: Pathology, Clinical picture and Treatment
Type I cryoglobulinemia
Paraproteinemias associated with Autoimmune Diseases
Infections and Paraproteinemia
Paraproteinemia In Autoinflammatory Diseases
Paraproteins associated with malignancy
Monoclonal Gammopathies with Miscellaneous Associations
Novel and Experimental Clone-directed Therapies
Non-Pharmacological Management of Paraproteinemia.

Summary: Rivers are the "blood vessels" of all living organisms on earth - they live in the water, drink the water or use it to spread into new regions in order to avoid overcrowding in specific locations. Since the early beginnings of human life on earth, riverbanks have been used as settlement sites, to provide food and for transport. However, since the oldest human cultures many agents of diseases have also spread along these rivers. Written by leading international parasitologists and physicians, this book discusses the involvement of rivers in the spread of diseases, but also their contributions to the development and destruction of human cultures. Examining past and current data, it shows how important and vulnerable river regions are and how they are increasingly endangered by pollution.

Contents:
Chapter 1: Important rivers and their worldwide contributions to epidemics on earth
Chapter 2: Conquering the God of Plague in China: a tale of over 60 years
Chapter 3: Cholera (Blue skin disease) and its history
Chapter 4: Spreading of cholera along rivers in early times of the USA before detection of the agents of disease
Chapter 5: Human cercarial dermatitis (HCD) or swimmer's itch along rivers and lakes
Chapter 6: Blood sucking leeches
not only nasty but also dangerous and helpful
Chapter 7: Important foodbornetrematodiases in Lower Mekong River Basin
Chapter 8: Important protozoan diseases in Lower Mekong River Basin
Chapter 9: Free-living amoebae and associated drug resistant bacteria in surface waters-A public health concern?
Chapter 10. Nile River, Impact on Human Health in Egypt from Pharaohs until now
Chapter 11: Epidemic status of schistosomiasis control in Guangdong province. Chapter 12: Konna
a help for a self-help project at the Niger River in Mali
Chapter 13: Leishmaniasis in Israel and Palestinian territories
Chapter 14: Past and present of tropical diseases in the Amazon river
Chapter 15: Brazil's big river projects and their impact on the occurrence of tropical diseases
Chapter 16: The major rivers and the genesis of the recent area of ticks Ixodes persulcatus in Western Siberia
Chapter 17: The Main River and Main-Danube Canal
a hub for Ponto-Caspian parasite invasion
Chapter 18: "Father Rhine"
from the Alps to the North Sea
Chapter 19: The River Rhine as hotspot of parasite invasions
Chapter 20: Free-living amoebae in rivers and ponds and their multiple role in environmental health.

Contents:
The eukaryotic pathogen databases : a functional genomic resource integrating data from human and veterinary parasites
From sequence mapping to genome assemblies
Sequencing and annotation of mitochondrial genomes from individual parasitic helminths
A beginners guide to estimating the non-synonymous to synonymous rate ratio of all protein-coding genes in a genome
Exploiting genetic variation to discover genes involved in important disease phenotypes
Identification and analysis of ingi-related retroposons in the trypanosomatid genomes
Approaches for studying mRNA decay mediated by SIDER2 retroposons in Leishmania
Gene suppression in schistosomes using RNAi
Construction of Trypanosoma brucei illumina RNA-seq libraries enriched for transcript ends
Techniques to study epigenetic control and the epigenome in parasites
The genome-wide identification of promotor regions in Toxoplasma gondii
RNA-seq approaches for determining mRNA abundance in Leishmania
Protein microarrays for parasite antigen discovery
A transposon-based tool for transformation and mutagenesis in Trypanosomatid protozoa
Separation of basic proteins from Leishmania using a combination of free flow electrophoresis (FFE) and 2D electrophoresis (2-DE) under basic conditions
Proteomic analysis of posttranslational modifications using iTRAQ in Leishmania
Large-scale differential proteome analysis in Plamsmodium falciparum under drug treatment
Use of ¹³C stable isotope labelling for pathway and metabolic flux analysis in Leishmania parasites
Molecular genotyping of Trypanosoma cruzi for lineage assignment and population genetics
Screening Leishmania donovani complex-specific genes required for visceral disease.

Summary: This textbook provides a comprehensive, reliable and practical guide to the dissection and parasitological examination of marine fish and cephalopods. The first part provides a general introduction, presenting basic information on: parasitology, ecology of the marine environment, history and methods of fisheries and aquaculture, as well as the ecology of marine fish and cephalopods and the impact of parasites on hosts. In turn, the second part provides general information on the morphology and anatomy of marine fish and cephalopods using the example of abundant morphotypes (including e.g. habitus photos of the body cavity and internal organs). The third part covers the relevant parasitic groups, their ecology (e.g. lifecycles, transmission), related diseases, and detection. The fourth part, a comprehensive methods section, provides essential protocols and applications of common dissection methods (for roundfish, flatfish and cephalopods) and stomach content analyses, as well as parasite preservation, preparation and molecular identification. Basic calculations of the most common infection and ecological parameters are also introduced. The book's fifth and final part provides information on health risks associated with fish and cephalopod consumption, as well as the prevention of human infection through the correct handling and processing of fish samples. The appendix provides e.g. blank sheets for recording fish dissections and parasitological examinations.

Contents:
Chapter 1. Introduction
Chapter 2. Anatomy and morphology of fish and cephalopods
Chapter 3. Parasitic groups
Chapter 4. Techniques
Chapter 5. Food safety considerations
Appendix
Register.

Summary: This book offers the first comprehensive review of parasitic Crustacea, which are among the most successful and diverse parasites. Starting with an introductory chapter, followed by an historic overview and topic-specific chapters, each presenting a different aspect of parasitic crustacean biology, it enables readers to gain a better understanding of how these parasites function and allows direct comparisons between the different parasitic crustacean groups. The authors also discuss, in depth, the adaptations and interactions that have made parasitic Crustacea as successful as they are today, covering topics ranging from the history of their discovery, their biodiversity, phylogeny, evolution and life strategies to their role as vectors, or hosts of other organisms, and their significance in ecological processes. Consisting of ten chapters from leading international experts in the field, this volume offers a one-stop resource for all researchers, lecturers, students and practitioners.

Contents:
Chapter 1. Introduction
Chapter 2. History of Discovery of Parasitic Crustacea
Chapter 3. Biodiversity and Taxonomy of the Parasitic Crustacea
Chapter 4. Adaptations and Types of Crustacean Symbiotic Associations
Chapter 5. Life Cycle and Life History Strategies of Parasitic Crustacea
Chapter 6. Effects of Parasitic Crustacea on Hosts
Chapter 7. Parasitic Crustacea as Vectors
Chapter 8. Hypersymbionts and Hyperparasites of Parasitic Crustacea
Chapter 9. Unravelling the Evolutions of the Rhizocephala: A Case study for Molecular Based Phylogeny in the Parasitic Crustacea
Chapter 10. The Ecological Significance of Parasitic Crustaceans.

Summary: This book provides an in-depth yet concise overview of the most common and emerging protozoa that cause diseases in both farm animals and companion animals. As outlined in the concise introduction, pathogenic protozoans represent an evolutionary highly diverse and little understood group of disease-causing microorganisms. For each of the featured parasitic unicellular eukaryotes, it discusses the morphology, lifecycle, epidemiology and host-pathogen interactions. In addition, the book highlights the latest developments in diagnostic methods, as well as prevention and treatment strategies. Thorough information on genomes and genetic manipulation strategies for some of the protozoa covered in this book is also included. Infections involving parasitic protozoa can cause productivity losses and/or reduce the quality of life of infected animals. Some infections are zoonotic, posing an on-going public health threat. In most cases, prevention and treatment are either non-existent or need considerable improvement. On the other hand, a great deal of research has recently been conducted on these organisms, yielding valuable new information on their global distribution and revealing the mechanisms of host-pathogen interactions at the molecular level - and essential insights that can be used for the development of new control tools. This book includes extensive information on both basic aspects and recent scientific discoveries on these protozoa and thus constitutes a unique resource for students, veterinarians, and researchers alike.

Summary: "User-friendly guide containing more than 70 full-color identifications of parasites commonly found in the clinical laboratory plus detailed descriptions of the most significant morphologic elements, ecology, and clinical significance."-- Provided by publisher.

Contents:
Primary hyperparathyroidism / Masi, L.
Asymptomatic primary hyperparathyroidism / Clarke, B.L.
Normocalcemic hyperparathyroidism / Corbetta, S.
Familial and hereditary forms of primary hyperparathyroidism / Cetani, F., Saponaro, F., Borsari, S., Marcocci, C.
Familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism / Vannucci, L., Brandi, M.L.
Parathyroid carcinoma / Cetani, F., Pardi, E., Marcocci, C.
Nonparathyroid hypercalcemia / Goltzman, D.
Secondary and tertiary hyperparathyroidism / Messa, P., Alfieri, C.M.
Hypoparathyroidism / Hakami, Y., Khan, A.
Classification of hypoparathyroid disorders / Cianferotti, L.
Clinical presentation of hypoparathyroidism / Giusti, F., Brandi, M.L.
Inactivating PTH/PTHrP signaling disorders / Mantovani, G., Elli, F.M.
Conventional treatment of hypoparathyroidism / Marcucci, G., Brandi, M.L.
A new era for chronic management of hypoparathyroidism : parathyroid hormone peptides / Marcucci, G., Brandi, M.L.

Summary: The book offers a comprehensive overview of all parathyroid gland disorders both, benign and malignant. It emphases established concepts, presents the ongoing controversies, challenges and debates on diagnosis and treatment of different parathyroid gland disorders, with a view of clarifying some uncertainties, making suggestions to resolve others, and establishing strategies to reach therapeutic success.In addition to general information on parathyroid gland embryology, surgical anatomy, histology and physiology, the chapters explore hyperparathyroidism, osteitis fibrosa cystica, hypoparathyroidism, hungry bone syndrome, the importance of calcium in the human body and differential diagnosis of hypercalcemia. The last chapters investigate post-thyroidectomy hypocalcemia, thyroid cancer, recent intra-operative localizing tools, and illustrate new techniques of parathyroidectomy, as well as parathyroid transplantation. The book will be an invaluable and indispensable source of knowledge and reference for all specialists and trainees entrusted with the care of patients suffering from parathyroid disease.

Contents:
Parathyroid Glands: Historical Review
Embryology of the Parathyroid Gland
Surgical Anatomy of the Parathyroid Gland
Histology of the Parathyroid Gland
Physiology of the Parathyroid Gland
Calcium: Why is it Important? Hyperparathyroidism (HPT)
Osteitis Fibrosa Cystica
Hypoparathyroidism
Metabolic Syndromes of Parathyroid Failure
Hungry Bone Syndrome
Post-thyroidectomy Hypocalcemia: Incidence and Risk Factors
Post-thyroidectomy Hypocalcemia: Clinical Presentation
Post-thyroidectomy Hypocalcemia: Prevention
Parathyroid Transplantation
Parathyroid Cancer
Intra-operative tools in Parathyroidectomy
Parathyroidectomy.

Summary: This concise book provides practical strategies to help nephrologists and endocrinologists correctly diagnose and treat the various forms of parathyroid disease they may encounter in the management of chronic kidney disease. Each chapter deals with various topics related to parathyroid gland anatomy and physiology, as well as diagnostic tests and their particularities in regard to chronic disease. The book highlights the range of therapies used for the treatment of secondary hyperparathyroidism, and critically analyses the latest research in the field. Providing an up-to-date review of the current literature, including innovations in both medical and surgical treatment and current indications for parathyroidectomy, this practice-oriented book is an excellent resource for nephrologists, endocrinologists, endocrine surgeons and family medicine physicians.

Contents:
Parathyroid glands in CKD: anatomy, histology, physiology and molecular biology in CKD
PTH regulation by the Klotho/FGF23 axis in CKD
Parathyroid Imaging in Patients with Renal Hyperparathyroidism
PTH regulation by phosphate and miRNAs
Relation between PTH and biochemical markers of MBD
Effect of PTH on the Hematologic System
Control of secondary hyperparathyroidism (SPHT) by older and newer vitamin D compounds
Parathyroidectomy in Chronic Kidney disease
Relation between PTH and the risk of mortality in CKD.

Summary: The RUBI Autism Network has developed and tested a structured parent training manual for children with autism spectrum disorder and disruptive behaviours. The manual is based on principles of applied behaviour analysis and is designed for therapists to use with parents of children with autism spectrum disorder and co-occurring challenging behaviours, such as tantrums, noncompliance, difficulties with transitions, and aggression.

Summary: "Parent training for disruptive behavior is an 11-session intervention for parents who wish to learn how to reduce disruptive behaviors and increase adaptive skills in their children with ASD. Each session introduces effective behavior change strategies and includes easy-to-use worksheets, checklists, and take-home activities to help parents apply what they have learned. By participating in this intervention with a trained therapist, parents can help their children overcome behavior problems, promoting happier kids and families."--Back cover

Summary: "Puberty is tough on kids--and maybe even more so on parents! Parenting Through Puberty explains the physical and emotional changes you can expect to see in your child. Dr. Kowal-Connelly covers the nitty-gritty of adolescents' changing bodies, and, critically, addresses the emotional toll puberty can take, covering issues of moodiness, body image, and self-esteem. Dr. Kowal-Connelly's reassuring advice also includes ways to encourage your tween or teen to embrace a healthy, active lifestyle in these crucial years, with tips on exercise and nutrition"--Publisher's description.

Contents:
Introduction
Part I. The physical changes. The basics of physical growth during puberty
Body image is everything
Variations of puberty growth and growing pains
Part II. The emotional changes. Understanding the emotional and intellectual stages of puberty
Moodiness, depression, and anxiety: what parents need to know
The value of your child's one-on-one time with the pediatrician
Part III. A time to value health and wellness. Taking control of weight issues
Living with a chronic condition
The effects of puberty on exercise and sports performance
Caring about health and wellness

Contents:
v
.1. For parents of children under school age.

Contents:
Understanding the risk of the offspring of parents with eating disorders
The broader context of the transition to parenthood in adults with eating disorders and their partners / Shiri Sadeh-Sharvit, Madeline R. Sacks, James D. Lock
The development of typical and atypical feeding and eating processes in children and youth / Shiri Sadeh-Sharvit, Madeline R. Sacks, James D. Lock
Two families seeking help
Overview of parent-based prevention
Adapting parent-based prevention to diverse family structures and backgrounds
Treatment planning and real-time evaluation using assessment tools
Phase one : setting up joint goals
Session 1 : gearing up
Session 2 : the family meal
Session 3 : embracing change
Phase two : distinguishing the parental eating disorder from parental functioning
Session 4-5, 7-8 : individual sessions with the affected parent
Session 6 : a conjoint meeting with both parents
Phase three : enhancing parental efficacy and family resilience
Parent-based prevention in action : Stacey and Rob
Parent-based prevention in action : Dave and Gabby.

Summary: "The Parietal Lobe, Volume 151, the latest release from the Handbook of Clinical Neurology series, provides a foundation on the neuroanatomy, neurophysiology and clinical neurology/neuropsychology of the parietal lobe that is not only applicable to both basic researchers and clinicians, but also to students and specialists who are interested in learning more about disorders brought on by damage or dysfunction. Topics encompass the evolution, anatomy, connections, and neurophysiology, the major neurological and neuropsychological deficits and syndromes caused by damage, the potential for improvement via transcranial stimulation, and the role of the parietal in the cerebral networks for perception and action"--Publisher's description.

Contents:
Section 1: Neuro-anatomy and neurophysiology of the parietal lobe. The history of the neurophysiology and neurology of the parietal lobe
The evolution of the parietal lobe: rats, monkeys, apes and humans
Cortico-cortical and cortico-subcortical connections of the parietal lobe
Somatosensory maps
The parietal lobe and pain perception
The parietal lobe and the vestibular system
Multisensory and sensorimotor maps
The parietal lobe "reach" region
Section 2: Neurological and neuropsychological deficits after parietal lobe damage. Somatosensory deficits
Pain syndromes and the parietal lobe
Optic ataxia
Simultanagnosia and balint's syndrome
Perceptual deficits of object identification: the apperceptive agnosias
Unilateral spatial neglect
Disorders of body knowledge
Constructional apraxia
Limb apraxia
Language deficits
Memory deficits
Gerstmann's syndrome
Parietal lobe epilepsy
Transcranial stimulations of the parietal lobe for improving neurological deficits
Section 3: The parietal lobe and brain networks for action and perception
The "dorsal" parietal stream
Action systems in the human brain
Parietal lobe and tool use
Parieto-frontal networks for eye-hand coordination and movements
The parietal lobe and memory
The parietal lobe "mirror" neuron system.

Contents:
Pathogenesis of Urothelial Carcinoma
Adequacy of Urine Specimens (Adequacy)
Negative for High Grade Urothelial Carcinoma (Negative)
Atypical Urothelial Cells (AUC)
Suspicious for High Grade Urothelial Carcinoma (Suspicious)
High Grade Urothelial Carcinoma (HGUC)
Low Grade Urothelial Neoplasia (LGUN)
Other Malignancies Primary and Metastatic and Miscellaneous Lesions
Ancillary Studies in Urinary Cytology
Cytopreparatory Techniques
Clinical Management, Including Microscopic Hematuria.

Summary: The first edition of The Paris System for Reporting Urinary Cytology introduced a completely new paradigm for detecting bladder cancer by urine cytology. This system concentrated on defining morphological characteristics of the most clinically significant form of bladder cancer, High Grade Urothelial Carcinoma. This new approach has been widely accepted throughout the world, and has become part of the daily practice of cytology. Considering that the first edition of The Paris System (TPS) introduced a new model of urinary cytodiagnosis, verification and expansion of initial material and data were anticipated. Based on evolving knowledge and readership requests, the group of highly experienced authors have created a new edition of TPS. This second edition includes areas and issues not originally covered. A new chapter on urine cytology of the upper tract, a rarely addressed topic, has been introduced. Furthermore, the issue of cellular degeneration is discussed in the criteria of all diagnostic categories. Examples of standardized reports are included in each chapter. Most importantly, a separate chapter presents data defining the risk of malignancy (ROM) for each diagnostic category to inform clinical management. New high quality images augment those of the first edition to better illustrate diagnostic clues and potential pitfalls. In addition to chapters on diagnostic criteria, current concepts of pathogenesis of bladder cancer, specimen adequacy and preparation, and ancillary tests are covered in separate chapters. A bonus to the volume is a comprehensive history of urine as the earliest diagnostic sample of human disease, richly illustrated with artworks from major museums. Written by internationally recognized authorities, this comprehensive and evidence-based guide to urine cytology is supported by the newest data confirming the original concept and significance of diagnostic criteria defining High Grade Urothelial Carcinoma. TPS is an essential tool for anyone who is practicing urinary cytology, including cytotechnologists, pathologists-in-training and practicing pathologists. This book should find a place in every cytology laboratory throughout the world. The Concept has been endorsed by the American Society of Cytopathology, and the International Academy of Cytology.

Contents:
Pathogenesis of Urothelial Carcinoma
Adequacy of Urine Specimens (Adequacy)
Negative for High-Grade Urothelial Carcinoma (Negative)
Atypical Urothelial Cells (AUC)
Suspicious for High-Grade Urothelial Carcinoma (Suspicious)
High-Grade Urothelial Carcinoma (HGUC)
Low-Grade Urothelial Neoplasia (LGUN)
Cytology of the Upper Urinary Tract
Other Malignancies Primary and Metastatic and Miscellaneous Lesions
Ancillary Studies in Urinary Cytology
Cytopreparatory Techniques
Risk of Malignancy (ROM) and Clinical Management.

Summary: Park's Pediatric Cardiology for Practitioners is the essential medical reference book for the ever-changing field of pediatric cardiology. Comprehensive in its content, it provides the practical guidance you need to diagnose and manage children with congenital and acquired heart disease. From history and physical examination through preventative treatment and the management of special problems, the fully revised 6th edition incorporates all of the latest concepts in cardiology, distilled in a way that is understandable to pediatricians, family practitioners, NPs, and PAs alike. Apply the latest knowledge and methods with coverage of surgical techniques in pediatric cardiology, the application of interventional non-surgical techniques, blood pressure standards, and cardiac arrhythmia treatments. Easily grasp the latest techniques with helpful line drawings throughout. Select the best approaches for your patients with extensive coverage of special problems, including congestive heart failure and syncope.

Summary: "Providing authoritative, everyday guidance in the diagnosis and management of children with congenital and acquired heart disease, Park's Pediatric Cardiology for Practitioners is the go-to reference of choice for pediatricians, family practitioners, NPs, and PAs--as well as medical students, residents, and fellows. The 7th Edition of this core text comprehensively covers every aspect of pediatric cardiology in an easy-to-read, practical manner for the non-specialist"--Publisher's description.

Contents:
Part 1: Basic tools in routine evaluation of cardiac patients. History taking
Physical examination
Electrocardiography
Chest radiography
Part 2: Special tools in evaluation of cardiac patients. Noninvasive imaging tools
Other noninvasive investigation tools
Invasive procedures
Pathophysiology. Fetal and perinatal circulation
Pathophysiology of left-to-right shunt lesions
Pathophysiology of obstructive and valvular regurgitation lesions
Pathophysiology of cyanotic congenital heart defects
Part 4: Specific congenital heart defects. Left-to-right shunt lesions
Obstructive lesions
Cyanotic congenital heart defects
Miscellaneous congenital cardiac conditions
Vascular ring
Chamber localization and cardiac malposition
Part 5: Acquired heart disease. Primary myocardial disease
Cardiovascular infections
Acute rheumatic fever
Valvular heart disease
Cardiac tumors
Cardiovascular involvement in systemic diseases
Part 6: Arrhythmias and atrioventricular conduction disturbances. Cardiac arrhythmias
Disturbances of atrioventricular conduction
Cardiac pacemakers and implantable cardioverter-defibrillators in children
Part 7: Special problems. Congestive heart failure
Systemic hypertension
Pulmonary hypertension
The child with chest pain
Syncope
Palpitation
Dyslipidemia and other cardiovascular risk factors
Athletes with cardiac problems
Cardiac transplantation
Appendices. Miscellaneous
Blood pressure values
Cardiovascular risk factors
Normal echocardiographic values
Drugs used in pediatric cardiology.

Summary: "Description and discussion of the many aspects of Parkinson disease (PD) is dogged by the fact that PD is an ambiguous concept. What we call PD is an etiologically and clinically heterogeneous meta-syndrome overlapping a number of other disorders. Definitions, diagnostic criteria, and classification schema provide essential common vocabularies for communication among clinicians and researchers. Definitions, diagnostic criteria, and classification schemes for PD, however, are constructs imposed on variable and imperfectly understood disease biology. Difficulties with formulation of PD definitions, diagnostic criteria, and classification schemes include historical and contemporary use of competing definitions of PD, disease heterogeneity, the existence of disorders with overlapping clinical and pathological features, and ambiguous use of the terms disease and syndrome. For the purposes of exposition and discussion in this book, an inclusive, perhaps vague, definition of PD is employed:"-- Provided by publisher

Contents:
Definition, History, Nosology, and Classification
Epidemiology
Pathology
Pathophysiology I : Basal Ganglia Architecture and The Standard Model
: Pathophysiology II : Neurotransmitter System Dysfunctions
Genetics of Parkinson Disease
Pathogenesis
Prodromal Parkinson Disease
Clinical Features I : Initial Evaluation
Clinical Features II : Non-Motor Features
Clinical Features III : Natural History
Pharmacology I : L-Dopa Pharmacokinetics and Pharmacodynamics
Pharmacology II : Treating Parkinson Disease
Surgery

Summary: What happens in the brain when we are ageing? How does neuronal cell death occur when we become forgetful? Which new therapies are available to combat the death of brain cells? This non-fiction book informs those interested in neuroscience and medicine about the latest findings on the therapy of neurodegeneration with a focus on Alzheimer's dementia and Parkinson's disease. Supported by illustrative drawings, Lars P. Klimaschewski presents the latest developments in neurobiological research on ageing in a comprehensible way and reports exciting news from the Alzheimer's and Parkinson's laboratories worldwide. From the contents Introduction to brain development: Why do we need billions of nerve cells? What distinguishes our cerebral cortex from that of other mammals? - Ageing and neurodegenerative diseases: Why are nerve cells lost? The normal ageing process; B-synuclein: A key protein in Parkinson's disease; Dementia and Alzheimer's disease: The amyloid and tau pathology; Viral infections in neurodegenerative diseases: Does Covid-19 lead to neurodegeneration? - Saving or replacing nerve cells: Stem cell, immune or antisense therapies? The author Prof. Dr. med. Lars P. Klimaschewski is a professor at the Medical University of Innsbruck, head of the Institute of Neuroanatomy there and the author of numerous papers on neuronal degeneration and regeneration.

Contents:
Intro
Preface
Contents
1 Introduction to Brain Development: Why do We Need so Many Nerve Cells?
1.1 Neurons and Glia in the Central Nervous System
1.2 What Happens During Brain Development?
1.3 Evolutionarily Old Brain Parts are Simpler in Structure than the Neocortex
1.4 What Distinguishes the Left from the Right Brain?
1.5 Brain Development in Childhood and Adolescence
1.6 The Child's Brain is Enormously Plastic and can Still Heal
1.7 Is a Large Brain "Smarter" than a Small One?
1.8 Absolute and Relative Brain Weight 1.9 With the Second Evolutionary Leap, Our Brain Reaches its Maximum Size
1.10 Neural Stem Cells Remain Capable of Dividing for a Long Time
1.11 The Frontal Lobe is Especially Important for Higher Brain Functions
1.12 The Prefrontal Cortex Encodes Human Specific Properties
1.13 Brain Performance in Comparison
Further Reading
2 Aging and Neurodegenerative Diseases: Why do Nerve Cells Die?
2.1 The Normal Aging Process
2.1.1 Mechanisms of Cellular Aging
DNA Telomeres Determine the Number of Cell Divisions
Aging Cells Maintain a Chronic Inflammation The Importance of Protein Homeostasis for Cellular Aging
Self-cleaning of Nerve Cells
Two Sides of a Coin: Oxygen Radicals
Endogenous Radical Scavengers Protect Our Nerve Cells
Chronic Inflammatory Processes in the Brain
2.1.2 Neuronal Cell Death
How do neurons die?
2.1.3 Blood Supply of the Aging Brain
Barrier Disorders are Not Uncommon in the Elderly
2.2 Parkinson's Disease
2.2.1 General Pathomechanisms
The Problem with Parkinson's Begins in the Lower Brainstem
2.2.2 Special Morphology of Affected Neurons
Special Requirements for Highly Branched Neurons Many Amine-releasing Neurons are Constantly Active and Therefore More Easily Stressed
2.2.3 Specific Causes of Parkinson's Disease
2.2.4 Alpha-synuclein: A Key Protein in Parkinson's Disease
Fibrils Are More Dangerous Than Aggregates
Aggregates Are Not Only Found in Nerve Cells
2.2.5 The Prion Theory of Parkinson's Disease
Cranial Nerves Transport Pathological Proteins into the Brain
The Difficulties of a Clear Pathogenesis of Parkinson's Disease
2.3 Dementia and Alzheimer's Disease
2.3.1 How Does Alzheimer's Disease Manifest Itself?
2.3.2 General Pathomechanisms

Contents:
The neurogenetics of Parkinson's Disease and putative links to other neurodegenerative disorders / C.M. Lill, C. Klein
Electron transport train / L. Aerts, V.A. Morais
Mitochondrial fission and fusion / V.L. Hewitt, A.J. Whitworth
Axonal mitochondrial transport / E. Shlevkov, T.L. Schwarz
Mitophagy / L. King, H. Plun-Favreau
Autophagy / P.A. Lewis, M. Perez-Carrion, G. Piccoli
Endocytosis and synaptic function / S.F. Soukup, P. Verstreken, S. Vilain
Neuroinflammation as a potential mechanism underlying Parkinsons Disease / C. Cebrián, D. Sulzer
Protien translation in Parkinson's Disease / J.W. Kim, L. Abalde-Atristain, H. Jia, I. Martin, T.M. Dawson, V.L. Dawson.

Summary: Top experts from all over the world have been brought together by the editors, to give a world of expertise on this important subject, with a strong emphasis on therapy and management.

Summary: This book addresses the challenges in the differential diagnosis and management of paroxysmal movement disorders. It provides the latest information on the genetics and pathophysiology, neurophysiology and neuroimaging of the core group of disorders in the field, namely the paroxysmal dyskinesias (PxD). Focused and concise, this guide features chapters that discuss other conditions that may be paroxysmal such as, episodic ataxia, startle syndromes and other more complicated groups of paroxysmal movement disorders such as ATP1A3 spectrum disorders. A chapter on secondary (acquired) paroxysmal dyskinesia highlights medical and other disorders that may result in paroxysmal dyskinesia. The book features a particularly nuanced chapter that discusses recent discoveries in the genetic aspects of PxD, relaying that paroxysmal dyskinesias are not channelpathies, but in fact are synaptophies and transportopathies. Additionally, expertly written chapters are supplemented by high quality images, tables, and videos. Paroxysmal Movement Disorders: A Practical Guide is primarily written to educate the reader on how to make a syndromic diagnosis of paroxysmal movement disorders and how to build the diagnostic work-up accordingly, as well as how to manage patients with paroxysmal movement disorders.

Contents:
Intro
Contents
Contributors
Chapter 1: Paroxysmal Dyskinesia: Definitions and Clinical Approach
Definitions
Clinical Approach
References
Chapter 2: The Early History of Paroxysmal Dyskinesias
Earliest Descriptions of Paroxysmal Dyskinesia Were Reported as Epilepsy
Earliest Reports That These Types of Conditions Are a Paroxysmal Disorder of Involuntary Movements
Early Reports of Paroxysmal Hypnogenic Dyskinesia
Early Reports of Transient Paroxysmal Dystonia/Torticollis in Infancy
Early Reports of Paroxysmal Ataxias and Tremor
References Chapter 3: Paroxysmal Kinesigenic Dyskinesia
PRRT2-Related PKD
PKD Associated with Other Genetic Conditions
Conclusions
References
Chapter 4: Paroxysmal Non-kinesigenic Dyskinesia
Introduction
Epidemiology
History
Genetics
Clinical Features
Investigations
Treatment
Conclusion
References
Chapter 5: Paroxysmal Exercise-Induced Dyskinesia
Introduction
SLC2A1 (GLUT1)-Related Paroxysmal Dyskinesia
GCH1-Related Paroxysmal Dyskinesia
ECHS1-Related Paroxysmal Dyskinesia
Pyruvate Dehydrogenase Deficiency
Early-Onset Parkinson's Disease Conclusions
References
Chapter 6: Acquired Paroxysmal Dyskinesia
Introduction
Clinical Features
Etiology
Autoimmune/Inflammatory
Endocrine/Metabolic
Hypoparathyroidism and Pseudohypoparathyroidism (HP and PHP)
Hyperthyroidism
Disorders of Glucose Metabolism
Autoimmune Disorders
Faciobrachial Dystonic Seizures (FBDS)
Vascular
Trauma
Spinal Cord Lesions
Functional (Psychogenic) Paroxysmal Dyskinesia
Miscellaneous Causes
Investigations
Treatment
References
Chapter 7: Pathophysiology of Paroxysmal Dyskinesia
Introduction
PRRT2 PRRT2 Mice
PNKD
PNKD Mice
GLUT1
Glut1 Mice
Other "Dyskinetic" Genes
SCN8A
KCNMA1
Conclusions
References
Chapter 8: Neurophysiology of Paroxysmal Dyskinesia
Introduction
Neurophysiology in the Diagnosis of Paroxysmal Dyskinesia
Electroencephalography
Electromyography
Other Clinical Neurophysiology Studies
Neurophysiology in the Pathophysiological Study of Paroxysmal Dyskinesia
Magnetoencephalography
Transcranial Magnetic Stimulation
Other Research Neurophysiology Studies
Conclusion
References Chapter 9: Other Paroxysmal Movement Disorders
Introduction
ADCY5 Mutations
ATP1A3 Spectrum Disorders
SCN8A Mutations
CACNA1A Mutations
SLC16A2 Mutations
References
Chapter 10: Functional Paroxysmal Movement Disorders
Introduction
Phenotypic Characteristics
Associated Signs
Diagnosis and Treatment Approach
References
Chapter 11: Episodic Ataxias
Introduction
EA1
EA2
EA3-EA8
Other Paroxysmal or Episodic Disorders Presenting with Ataxia
References
Index

Contents:
History of the discovery of poly (ADP-ribose)
Discovery of the PARP superfamily and focus on the lesser exhibited but not lesser talented members
The role of PARPs in DNA Strand Break Repair
TIPs: Tankyrase Interacting Proteins
PARP and Carcinogenesis
Multitasking roles for poly(ADP-ribosyl)ation in aging and longevity
Overview of PARP Inhibitor Design and Optimization
Structure Based Design of PARP Inhibitors
Preclinical chemosensitization by PARP inhibitors
Classification of PARP inhibitors based on PARP trapping and catalytic inhibition, and rationale for combinations with topoisomerase I inhibitors and alkylating agents
Radiosensitisation by poly(ADP-ribose) polymerase inhibition
The vasoactivity of PARP inhibitors
Synthetic lethality with Homologous Recombination Repair defects
Targeting tumour hypoxia with PARP Inhibitors: Contextual synthetic lethality
Other determinants of sensitivity
Synthetic sickness with molecularly targeted agents against the EGFR pathway
Disruption of DNA repair by cell cycle and transcriptional CDK inhibition
Resistance to PARP Inhibitors Mediated by Secondary BRCA1/2 Mutations
PARP inhibitor resistance
what is beyond BRCA1 or BRCA2 restoration
Introduction to PARPi clinical trials and future directions
Clinical trials investigating PARP inhibitors as single agents
Clinical trials of PARP inhibitors with chemotherapy
Combination of PARP inhibitors with clinical radiotherapy
Biomarkers for PARP Inhibitors.

Summary: "Preface: The current format of the Part 2 MRCOG examination is now well established with the change to written papers containing single best answer (SBA) and extended matching questions (EMQs) commencing in March 2015. The Part 2 MRCOG examination is primarily concerned with testing candidates' knowledge of the entire specialty of Obstetrics & Gynaecology as defined by the RCOG curriculum. The new Part 3 examination now provides the clinical assessment. It is always preferable to enter an examination having had ample opportunity to practice the type of questions with which one will be faced. To this end we have produced this book that contains 250 SBA and 250 EMQ questions"--Provided by publisher.

Contents:
Questions. IT, Governance and Research
Core Surgical Skills
Postoperative Care
Surgical Procedures
Antenatal Care
Maternal Medicine
Management of Labour
Management of Delivery
Postnatal Care
Gynaecological Problems
Subfertility
Sexual and Reproductive Health
Early Pregnancy Problems
Gynaecological Oncology
Urogynaecology and Pelvic Floor Problems
Explanations. IT, Governance and Research
Core Surgical Skills
Postoperative Care
Surgical Procedures
Antenatal Care
Maternal Medicine
Management of Labour
Management of Delivery
Postnatal Care
Gynaecological Problems
Subfertility
Sexual and Reproductive Health
Early Pregnancy Problems
Gynaecological Oncology
Urogynaecology and Pelvic Floor Problems .

Summary: The new edition includes increased video/DVD coverage, new chapters on BRAVA tissue expansion, flaps, and increased detail on mega-filling the breast with fat. The book is published with a bundled eBook, which includes an image library so all the images can be downloaded.

Contents:
Part One: Evolution of oncoplastic surgery
Fundamentals of oncoplastic breast surgery
Current approach to oncoplastic breast surgery
How to incorporate oncoplastic surgery into your practice
Part Two: Principles and considerations of oncoplastic breast conservation
Applied anatomy and breast aesthetics: definition and assessment
Breast-conserving therapy
Breast-conserving therapy: decision-making and anticipating the unfavorable aesthetic and functional result
Oncologic safety of the oncoplastic approach for breast conservation surgery
Improving the partial mastectomy deformity
Improving the quadrantectomy defect
Breast radiotherapy in oncoplastic surgery
Indications and benefits of oncoplastic breast surgery
Designing the oncoplastic operation
Timing of the oncoplastic reconstruction: immediate, delayed, and delayed-immediate
Psychosocial aspects of oncoplastic breast conservation
Part Three: Immediate partial breast reconstruction
Reduction techniques to optimize results
Reduction and mastopexy techniques with parenchymal autoaugmentation
Central defect reconstruction
The role of local flaps as volume replacement in oncoplastic reconstruction
Latissimus dorsi miniflap reconstruction
Endoscopic latissimus dorsi flap reconstruction
Omental flap reconstruction
Pedicled perforator flap reconstruction
Partial breast reconstruction using distant flaps
Part Four: Correction of the breast-conserving therapy deformity: delayed partial breast reconstruction
Classification and analysis of the breast-conserving therapy deformity
Rearrangement surgery
Correction of the breast-conserving therapy deformity using local flaps
Perforator flap reconstruction of breast-conserving therapy deformities
Local perforator flaps in oncoplastic breast-conserving surgery: the nottingham experience
Breast lumpectomy reconstruction with external vacuum expansion and autologous fat grafting
Fat grafting in the breast-conserving therapy deformity
Can implants correct a breast-conserving therapy deformity?
Part Five: Outcomes and future directions
Cancer surveillance after partial breast reconstruction
Complications and outcomes after immediate partial breast reconstruction
Outcomes and tumor recurrence after oncoplastic surgery of the breast: eighteen-year follow-up.

Summary: It has long been claimed that addressing biodiversity loss and other environmental problems demands a better understanding of the social dimensions of conservation; nevertheless, the active participation of indigenous peoples and local communities (IPLCs) in conservation initiatives is still a challenging and somehow controversial issue. In this context, this book hopes to give voice to other perspectives related to biodiversity conservation beyond the "fortress conservation" model and emphasize one of the pillars of democracy - popular participation. It covers a wide range of environments and issues of special significance to the topic, such as the expansion of culturally constructed niches, protected areas and food security, community-based management, participatory agroforestry, productive restoration and biocultural conservation. The contents also explore the limitations and shortcomings of participatory practices in protected areas, the relationship between the global crisis of democracy and the decline of biocultural diversity, as well as present current discussions on policy frameworks and governance systems for effective participatory biodiversity conservation. In sum, this book provides a comprehensive and realistic perspective on the social dimensions of conservation based on a series of interrelated themes in participatory biodiversity conservation. The connections between biocultural conservation and the current political and economic environment are highlighted through the chapters and the book closes with a debate on ways to reconcile human welfare, environmental justice and biodiversity conservation.

Contents:
1. Concepts and evolving perspectives on biodiversity conservation
2. Domesticated Nature: The culturally constructed niche of humanity
3. The right to food? Protected areas, conservation and access
4. The role of local perceptions in environmental diagnosis
5. People and nature conservation: Participatory praxis in natural protected areas planning and management
6. Policy trends in the recognition of indigenous and local knowledge in Amazonia
7. Community-based management of Amazonian biodiversity assets
8. Mariculture of macroalgae as a social and environmental alternative in traditional communities located in the semi-arid coastal region of northeastern Brazil
9. Challenges for rural livelihoods, participatory agroforestry and biodiversity conservation in a neotropical Mexican MAB reserve
10. Participatory monitoring of natural commons in Brazil: Lessons from the literature and the field
11. Productive restoration as a tool for socio-ecological landscape conservation: The case of "La Montaña" in Guerrero, Mexico
12. ATBC's conservation activities around the world: How effective have our declarations and resolutions been in driving policy change and management responses?
13. Avoiding deforestation policies: A socio-political approach
14. Participatory biodiversity conservation: What prospects?

Summary: "This groundbreaking resource explores core issues in participatory health research (PHR) and traces its global emergence as a force for improving health and well-being, health care services and quality of life."--Publisher.

Contents:
Central ThemesIntroduction:Michael WrightBuilding Consensus, Celebrating Diversity: The Work of the International Collaboration for Participatory Health Research:Michael WrightWhat is Participatory Health Research?Michael Wright, Jane SpringettEthics in Participatory Health Research:Sarah BanksEvaluating Participatory Health Research:Nina Wallerstein, John Oetzel, Jane SpringettThe Challenges of Reviewing the Participatory Health Research Literature:Jon Salsberg, Janet HarrisChildren and Participatory Health Research:Lisa GibbsThe Role of Participatory Health Research in Training Health Professionals:Irma BritoDemonstrating Impact in Participatory Health Research:Tina Cook, Jane SpringettThe Role of Theory in Participatory Health Research:Sónia AcioliRegional PerspectivesParticipatory Health Research in Portuguese-Speaking Countries: A Review:Irma BritoPartKommPlus
The German Research Consortium for Healthy Communities:Michael WrightParticipatory Health Research and Post-Colonial Scholarship in Latin America:Francisco MercadoParticipatory Research in Health Care Organizations in North America: A Review:Paula Bush, Jon SalsbergParticipatory Health Research for Planning Work in Sweden:Margareta RämgårdParticipatory Health Research for Improving Healthcare in the Netherlands:Tineke AbmaA History of Participatory Health Research in North America: A Look Back From Where We Are Today:Jon SalsbergParticipatory Health Research in the UK and Ireland:Jane Springett, Siobhán O'Higgins.

Summary: Plant breeding has played a significant role in the development of human civilizations. Conventional plant breeding has significantly improved crop yield by genetically manipulating agronomically important traits. However, it has often been criticized for ignoring indigenous germplasm, failing to address the needs of the marginal and the poor farmers, and emphasizing selection for broad instead of local adaptation. Participatory plant breeding (PPB) is the process by which the producers and other stakeholders are actively involved in a plant-breeding programme, with opportunities to make decisions throughout. The Working Group on Participatory Plant Breeding (PPBwg) was established in 1996 under the framework of the Consultative Group on International Agricultural Research (CGIAR). Research in PPB can promote informed participation and trust in research among consumers and producers, and in recent years, PPB has had a significant impact on food production by quickly and cost-effectively producing improved crop varieties. At the same time, there has been significant research in the area. PPB offers significant advantages that are particularly relevant to developing countries where large investments in plant breeding have not led to increased production, especially in the marginal environments. In addition to the economic benefits, participatory research has a number of psychological, moral, and ethical benefits, which are the consequence of a progressive empowerment of the farming communities. PPB can empower groups such as women or less well-off farmers that are traditionally left out of the development process.This book explores the potential of PPB in the coming decades. The topic is more relevant since international breeding efforts for major crops are aimed at decentralizing local breeding methods to better incorporate the perspective of end users into the varietal development process. The first book incorporating the upcoming research on this novel breeding approach, it reviews the important tools and applications of PPB in an easy-to-read, succinct format, with illustrations to clarify these complex topics. It provides readers with a basic idea of participatory plant breeding as well as advances in the field and insights into the future to facilitate the successful integration of farmers into breeding programmes. This book is a valuable reference resource for agriculturists, agricultural advisers, policy makers, NGOs, post-doctoral students and scientists in agriculture, horticulture, forestry and botany.

Contents:
Particle Therapy in the Third Millennium Current Status and Future Outlook
Development of Cyclotrons for Proton and Particle Therapy
Development of C-ion Radiotherapy Technologies in Japan
Physical rationale for protontherapy and elements to build a clinical center
Radiation Dosimetry of Proton Beams
Clinical pencil beam scanning: present and future practices
Treatment planning for protons
An essay.- Radiation Therapy with Protons and Heavy Ions
Robustness Quantification and Worst-Case Robust Optimization in Intensity-Modulated Proton Therapy
Modeling of Biological Effect of Charged Particles for C-Ion RT
SFUD, IMPT and plan robustness.

Summary: This edited volume brings together the expertise of numerous specialists on the topic of particles - their physical, chemical, pharmacological and toxicological characteristics - when they are a component of pharmaceutical products and formulations. The book discusses in detail properties such as the composition, size, shape, surface properties and porosity of particles with respect to how they impact the formulations and products in which they are used and the effective delivery of pharmaceutical active ingredients. It considers all dosage forms of pharmaceuticals involving particles, from powders to tablets, creams to ointments, and solutions to dry-powder inhalers, also including the latest nanomedicine products. Further, it discusses examples of particle toxicity, as well as the important subject of pharmaceutical industry regulations, guidelines and legislation. The book is of interest to researchers and practitioners who work on testing and developing pharmaceutical dosage and delivery systems.

Contents:
Intro; Preface; Contents; Editors and Contributors; 1 Introduction; Abstract; 1.1 Objective of This Book; 1.2 Pharmaceutical Products; 1.3 Relevance of Particle and Powder Characteristics for Product Quality; 1.4 Particle, Powder and Liquid Dispersion Characteristics [54-56, 58]; 1.4.1 Composition; 1.4.2 Particle Size and Particle Size Distribution (PSD); 1.4.3 Particle Shape; 1.4.4 Particle Morphology; 1.4.5 Particle Density and Porosity; 1.4.6 Surface Area; 1.4.7 Wettability; 1.4.8 Zeta Potential; 1.4.9 Powder Packing, Density and Porosity; 1.4.10 Powder Flowability; 1.4.11 Segregation 1.4.12 Rheology of Emulsions and Suspensions [55, 60]1.4.13 Stability of Emulsions and Suspensions [55, 60]; 1.5 Measurement Methods and Techniques [52, 54, 55]; 1.5.1 Sampling [39, 57, 70]; 1.5.2 Dispersion/Dilution [40, 58]; 1.5.3 Measurement Techniques for API Concentration and Coating; 1.5.4 Measurement Techniques for Particle Characteristics; 1.5.4.1 True Skeleton Density; 1.5.4.2 Crystallinity and Crystal Structure; 1.5.4.3 Elemental Analysis; 1.5.4.4 Particle Size Distribution (PSD); 1.5.4.5 Particle Shape; 1.5.4.6 Surface Area, Porosity and Pore Size Distribution; 1.5.4.7 Wettability 1.5.4.8 Zeta Potential1.5.5 Measurement Methods for Powder Characteristics; 1.5.5.1 Bulk Density; 1.5.5.2 Flow Properties; 1.5.6 Characterization Techniques for Liquid Dispersions; 1.5.7 Characterization Techniques for Sprays; 1.6 Set up of the Book; 1.7 Definitions, Abbreviations and Symbols; References; 2 Guide to Pharmaceutical Product Quality; Abstract; 2.1 Introduction; 2.2 Quality by Design and Process Analytical Technology; 2.3 Guidelines for Quality Control of Drug Substances; 2.4 Analysis of PSD and Particle Shape and Acceptance Criteria; 2.5 Quality Management 2.6 Definitions, Abbreviations and SymbolsReferences; 3 Bio-nano: Theranostic at Cellular Level; Abstract; 3.1 Introduction; 3.2 Janus Particles, Superparticles and Core-Shell Particles; 3.2.1 Janus-Particles; 3.2.2 Superparticles; 3.2.3 Core-Shell Particles; 3.3 Overview Drug Delivery Systems (DDS); 3.4 Surface Modification; 3.4.1 Amphiphillic Micelle Structures; 3.4.2 Multidentate Polymeric Ligands; 3.4.3 Bi-functional Ligands; 3.5 Biomedical Application-Diagnostics and Therapy; 3.5.1 Magnetic Resonance Imaging (MRI); 3.5.2 Hyperthermia; 3.5.3 Computed Tomography (CT) 3.5.4 Photothermal and Photodynamic Therapy3.6 Tumor Microenvironment; 3.7 Biodistribution and Functionalization of the DDS; 3.8 Bio-nano Interface; 3.9 Electronic Properties of Nanomaterials; 3.9.1 Luminescence of Quantum Dots; 3.10 Nanoparticles as Enzyme Mimetics; 3.11 Protein Corona; 3.12 Passive and Active Targeting; 3.13 Endocytose; 3.14 Gatekeeper; 3.15 Biorelated Degradation of the DDS; 3.16 Cancer Immunotherapy; 3.17 Limitation of the DDS; 3.18 Abbreviations; References; 4 Moving Liposome Technology from the Bench to the Oncological Patient: Towards Performance-by-Design; Abstract

Contents:
What is mental health recovery and how does it relate to person-centered care planning?
Key principles and practices of person-centered care planning
Preparing for the journey : understanding various types of recovery plans and orienting participants to the PCCP process
Strength-based assessment, integrated understanding, and setting priorities
Creating the plan through a team meeting
Documentation of PCCP : writing the plan to honour the person and satisfy the chart
So you have a person-centered care plan, now what?
Plan implementation and quality monitoring
PCCP implementation : common concerns & person-centered responses.

Summary: The Certified Bariatric Nurse (CBN) designation was created by the American Society for Metabolic and Bariatric Surgery to fill the rapidly growing need for nurses specialized in the care of patients undergoing weight loss surgery. This book approaches this subject area to assist nurses interested in passing the CBN exam. It can also be used as a general resource for those interested in a comprehensive but concise review of the rapidly growing field of Bariatric Surgery. This would include medical students, residents, dietitians, and other allied health professionals. Dr. Marc Neff is a recognized expert in the field of Bariatric Surgery. In his current position, his hospital is fortunate to have several CBNs caring for the Bariatric patients. With his guidance, along with several nurses who successfully completed the CBN designation, the authors have created a concise, "quick hit" review of the material required to successfully pass the exam. The format is short chapters followed by 5-10 review questions with in-depth explanations. Where appropriate, graphics are provided to highlight the essential anatomy and surgical procedures. Questions are in multiple choice format to simulate the actual CBN exam.

Summary: Edited by Dr. Marc Neff, Passing the General Surgery Oral Board Exam, Second Edition helps candidates prepare for the General Surgery Oral Board Exam in a different way than other review books. In addition to covering concepts frequently addressed on the test, the review also alerts you to 'common curveballs' and 'strikeouts'- the unexpected problems or seemingly benign actions (or inactions) that could result in a missed diagnosis or misdiagnosis, and thus result in failure to pass the exam. Fully updated and expanded to reflect the many changes in standards of care, this unique study guide is the first to expose the potential traps and pitfalls of the exam by providing examples of how the questions may be asked and what not to say in response.

Contents:
Organizational Theme / Marc A. Neff
Breast / Linda Szczurek
Colon and Small Bowel / Linda Szczurek, Devin C. Flaherty, and Marc A. Neff
Abdominal Endocrine / Anna Goldenberg Sandau and Roy L. Sandau
Head and Neck Endocrine / Anna Goldenberg Sandau and Roy L. Sandau
Esophagus / Christina Sanders
Genitourinary / Marc A. Neff
Hepatobiliary / Linda Szczurek
Pancreas / Linda Szczurek, Jonathan Nguyen, and Marc A. Neff
Pediatric / Linda Szczurek
Perioperative Care / Jonathan Nguyen and Marc A. Neff
Skin and Soft Tissue / Marc A. Neff
Stomach and Duodenum / Marc A. Neff and Devin C. Flaherty
Thoracic / Nicole M. Harris
Trauma and Critical Care / Leigh Ann Slater [and others]
Vascular / Brandt D. Jones
Conclusions: Last Curveballs Considerations / Marc A. Neff.

Summary: This autobiography chronicles the life and career of Haralampos M. Moutsopoulos, an internationally renowned professor of medicine and prolific researcher on Sjogrens syndrome and autoimmune rheumatic diseases. In language that is simple and direct, he takes us on a fascinating journey from the days of his first scientific awakenings at a hospital in his native town of Ioannina, Greece, through his university years in Athens and training in the U.S., to his eventual return to his homeland. In Greece, he developed two centers of excellence in his field, first at the newly founded University of Ioannina Medical School Department of Internal Medicine and, second, at the Athens University Medical School, Department of Pathophysiology, where he taught until his retirement in 2011. Along the way, he introduces us to his teachers and mentors, and to the colleagues and students he mentored in turn, many of whom went on to assume high-ranking positions in Greece and abroad. A major theme throughout the book is his impassioned struggle for excellence, meritocracy, and transparency in universities and in the National Health System in Greece. Peppered with both amusing and unsettling incidents from this lifelong crusade to raise professional standards and against misconduct, the book is a must-read for anyone interested in learning about or entering the medical profession.

Contents:
1. Coming of Age
2. Student Years
3. Young Physician
4. In the Army
5. Public Health Service.

Contents:
ABOUT THE FRCS
ANATOMY
Upper limb
Lower limb
Surgical approaches
SPINE
Spinal trauma
Tumours
Infections
Stenosis
Disc prolapse
Scoliosis (Paediatric and adult)
Back pain
Ankylosing spondylitis
Rheumatoid spine
Spondylolisthesis
Cervical spondylosis
Kyphosis
PAEDIATRICS
DDH
Perthes
SCFE
CP
Neurofibromatosis
Skeletal dysplasias
Paediatric trauma
Club feet
Metatarsus adductus
Congenital vertical talus
BASIC SCIENCES
Statistics
Cartilage
Bone
Muscles
Tendons/ligaments
Meniscus
Radiation
Arthritides
Metals
Theatre design
Traction
Free body diagrams
Gait cycle
LOWER LIMB ARTHROPLASTY
Hip replacement
Knee replacement
TRAUMATOLOGY
Upper limb
Lower limb
Scores in trauma
FOOT AND ANKLE
Biomechanics
Arthroscopy
Arthritis
Instability
Hallux rigidus
Hallux valgus
Interdigital neuroma
Neuropatic foot
Rheumatoid foot
Tarsal tunnel
Lesser toe deformities
Pes planus
Charcot Marie Tooth
ORTHOTICS/AMPUTATIONS/REHABILITATION
Orthotics and braces
Amputation
Rehabilitation
SPORTS
HANDS
Rheumatoid hand
Tendon injuries (flexors/extensors)
Distal radial fractures
Scaphoid fractures
Kienbocks disease
Trigger fingers
Dupuytrens disease
DRUJ and TFCC injuries
Concepts of tendon transfers
Carpal instability
CMCJ thumb arthritis
Wrist arthritis
Carpal tunnel syndrome
De quervain tenosynovitis
UPPER LIMB
ACJ arthritis
Sub acromial impingement
Cuff tear
Cuff arthropathy
Shoulder arthritis
Shoulder rheumatoid arthritis
Shoulder ON
Calcific tendinopathy
Frozen shoulder
SLAP
Shoulder instability
Elbow OA
Rheumatoid arthritis
Instability
Tendinopathies
Biceps rupture
Elbow arthroscopy
Elbow arthroplasty
ONCOLOGY
Basic concepts (classifications, biopsy...)
Benign tumors (bone, cartilage, others)
Malignant tumors (bone, cartilage, others)
PHYSICAL EXAMINATIONS
Hip
Knee
Shoulder
Spine
Elbow
Hand
Foot and ankle
Gait cycle
GEMS
What you will not find in the books but might be asked in the exam
UP TO DATE REFERENCES
Per topics.

Contents:
Intro
Foreword
Preface
Acknowledgements
Contents
About the Editors
Contributors
1: The Person Before the Patient: The Importance of a Good History
1.1 Introduction
1.2 When to Attain a Patient History in the ICU
1.3 How to Obtain an Effective Patient History in the ICU
1.3.1 The Clinical Frailty Scale
1.3.2 Patient Questionnaires: Key Relative Involvement
1.4 What a Good History Should Include in the ICU
1.5 Why an Early, Detailed History Is Important
1.5.1 Family: Key Relationships
1.5.2 Mobility 1.5.3 Functional Independence and Housing
1.5.4 Hobbies, Interests and Work
1.5.5 Medical History
1.5.6 Lifestyle History
1.5.7 Understanding and Expectations
1.6 Conclusions
References
2: Respiratory and Mechanical Ventilation Management: Avoidance of Complications
2.1 Introduction
2.2 Respiratory Management During Invasive Mechanical Ventilation
2.2.1 Endotracheal Suctioning
2.2.2 Subglottic Suctioning
2.2.3 Humidification of Respiratory Gases
2.3 Chest Physiotherapy
2.3.1 Manual or Ventilator Pulmonary Hyperinflation 2.3.2 Manual Chest Compressions/Vibrations (MCC)
2.4 Mechanical In-Exsufflation (MI-E)
2.5 Inspiratory Muscle Training
References
3: Patient Care: From Body to Mind
3.1 Introduction: Patient Care in a Critical Environment
3.2 "Interventional Patient Hygiene"
3.3 Bathing and Skin Integrity
3.4 Oral Care
3.5 Eye Care
3.6 Pain Assessment and Nursing Care
3.6.1 Assessment
3.6.2 Management
3.7 Conclusion
References
4: Nutrition: Calories Count
4.1 Introduction
4.2 Presence of Pre-existing Conditions on Admission to ICU 4.2.1 Chronic Co-morbidities
4.2.2 Sarcopenia
4.2.3 Malnutrition
4.3 Factors Which Affect Nutritional Status During ICU Stay
4.3.1 Metabolic Response to Critical Illness
4.3.2 Iatrogenic Undernutrition
4.3.3 Immobilisation
4.4 Assessing Malnutrition in the Critically Ill Patient
4.4.1 Nutrition Screening Tools
4.4.2 Muscle Mass
4.5 Strategies to Improve Physical and Functional Outcomes
4.5.1 Targeted Nutrition Delivery
4.5.2 Volume-Based Feeding
4.5.3 Energy Versus Protein
4.5.4 Exercise and Protein
4.5.5 Supplementation 4.6 Recovery Phase of Critical Illness
4.7 Adequacy of Nutrient Delivery
4.7.1 Factors Influencing Nutritional Recovery
4.8 Potential Strategies to Facilitate Optimal Nutritional Delivery in the Recovery Phase of Critical Illness
4.8.1 Coordinated Multidisciplinary Approach to Nutritional Care
4.8.2 Systematic Handover to Ward-Based Staff
4.8.3 Early Involvement of Family
4.8.4 Conclusion
References
5: Promoting Independence
5.1 Introduction: What Is Dysphagia?
5.2 Dysphagia Assessment and Screening
5.3 Bedside Assessment

Contents:
1. History of electrophysiology and the patch clamp / Alexei Verkhratsky and Vladimir Parpura
2. Whole-cell patch-clamp analysis of recombinant NMDA receptor pharmacology using brief glutamate applications / Nathan G. Glasgow and Jon W. Johnson
3. Patch clamp combined with voltage/concentration clamp to determine the kinetics and voltage dependency on N-methyl-D-aspartate (NMDA) receptor open channel blockers / Chris G. Parsons and Kate E. Gilling
4. State-of-the-art automated patch clamp: heat activation, action potentials, and high throughput in ion channel screening / Sonja Stoelzle-Feix
5. Industrializing electrophysiology: HT automated patch clamp on SyncroPatch96 using instant frozen cells / Liudmila Polonchuk
6. Planar patch clamp for neuronal networks
considerations and future perspectives / Alessandro Bosca, Marzia Martina, and Christophe Py
7. Methods for the study of synaptic receptor functional properties / Enrica Maria Petrini and Andrea Barberis
8. Single cell RT-PCR, a technique to decipher the electrical, anatomical, and genetic determinants of neuronal diversity / Maria Toledo-Rodriguez and Henry Markham
9. Whole-cell voltage clamp on skeletal muscle fibers with the silicone-clamp technique / Romain Lefebvre, Sandrine Pouvreau, Claude Collet, Bruno Allard, and Vincent Jacquemond
10. Multiphoton imaging approaches for studying striatal dendritic excitability / Joshua L. Plotkin and D. James Surmeier
11. Investigation of synaptic microcircuits using patch-clamp paired recordings in acute brain slices / Giovanni Russo and Stefano taverna
12. Outside-out "sniffer-patch" clamp technique for in situ measures of neurotransmitter release / Émilie Muller-Chrétien
13. A cost-effective method for preparing, maintaining, and transfecting neurons in organotypic slices / Cary Soares, Kevin F.H. Lee, Denise Cook and Jean-Claude Béïque
14. Acute brain slice methods for adult and aging animals: application of targeted patch clamp analysis and optogenetics / Jonathan T. Ting, Tanya L. Daigle, Qian Chen and Guoping Feng
15. Synaptic connectivity in engineered neuronal networks / Peter Molnar, Jung-Fong Kang, Neelima Bhargava, Mainak Das and James J. Hickman
16. Modeling of action potential generation in NG108-15 cells / Peter Molnar and James J. Hickman
17. Whole-cell patch-clamp recordings in freely moving animals / Albert K. Lee, Jâerãome Epsztein and Michael Brecht
18. Pressure-polished borosilicate pipettes are "universal sealer" yielding low access resistance and efficient intracellular perfusion / Marco Aquila, Mascia Benedusi, Anna Fasoli and Giorgio Rispoli
19. Current recordings at the single channel level in adult mammalian isolated cardiomyocytes / Romain Guinamard, Thomas Hof, and Laurent Sallâe
20. Dynamic clamp as a tool to study the functional effects of individual membrane currents / Géza Berecki, Arie O. Verkerk, Antoni C.G. van Ginneken and Ronald Wilders
21. Dynamic clamp in cardiac and neuronal systems using RTXI / Francis A. Ortega, Robert J. Butera, David J. Christini, John A. White and Alan D. Dorval II
22. Ion selectivity of pore-forming peptides and ion channels measured in xenopus oocytes / Thierry Cens and Pierre Charnet
23. Principles of single-channel kinetic analysis / Feng Qin.

Summary: This third edition of the essential guide has been extensively revised and updated and includes additional color illustrations. It reflects the rapid expansion in knowledge of the subject due to progress in the chemical, immunological, and clinical fields.

Contents:
Intro
Preface to Fourth Edition
Introductory Remarks
Nomenclature: A Few Definitions
Xenobiotics
Haptens
Modifications of Molecules [3]
An Updated Overview of the Skin Barrier Structure and Function
References
Contents
Contributors
Abbreviations
Part I: Patch Testing
Chapter 1: Pathophysiology of Allergic and Irritant Contact Dermatitis
1.1 Introduction
1.2 Pathophysiology of Irritant and Allergic Skin Inflammation
1.2.1 Irritant and/or Allergic Chemicals
1.2.2 Skin Irritation: Activation of Innate Immunity
1.2.2.1 Innate Immunity 1.2.2.2 Skin Irritation: Mechanisms of Action
1.2.2.3 Direct Responsibility of the Chemical in ICD
1.3 Skin Allergy: The Role of Specific Immunity
1.3.1 Antigen-Specific Immunity
1.3.2 Skin Allergy: Mechanisms of Action
1.3.3 Indirect Responsibility of Chemicals in Skin Irritation
1.4 Pathophysiology of Skin Inflammation: The Connection Between Innate and Acquired Immunity
References
Chapter 2: Diseases for Which Patch Testing Is Recommended: Patients Who Should Be Investigated
2.1 Allergic Contact Dermatitis
2.1.1 Clinical Signs and Symptoms 2.1.2 Histopathological Features
2.1.2.1 Epidermal Lesions
2.1.2.2 Dermal Changes
2.2 Allergic Contact Dermatitis Syndrome
2.2.1 Stage 1 of ACDS
2.2.1.1 Morphological Aspects
2.2.1.2 Topographical Variants
2.2.2 Stage 2 of ACDS
2.2.3 Stage 3 of ACDS
2.2.3.1 Stage 3A of ACDS
2.2.3.2 Stage 3B of ACDS
2.3 Allergic Contact Dermatitis Versus Irritant Contact Dermatitis: Criteria for Differential Diagnosis
2.4 Other Skin Diseases in Which Patch Testing Is of Major Interest
2.5 Algorithmic Approach: Key Role of Patch Testing 2.6 Hand Dermatitis: Definition and Procedures Applied in Differential Diagnosis
2.6.1 Hand Dermatitis: Exogenous and Endogenous Factors
2.6.2 A Classification of Hand Dermatitis
2.6.3 Tools of Investigation
2.6.4 Hand Dermatitis: Some Examples of an Algorithmic Approach
2.6.5 Hand Eczema: A Controversial Issue
References
Chapter 3: Patch Testing Methodology
3.1 Historical Background
3.2 Definition and Aims
3.2.1 Requirements for an Ideal Patch Testing Procedure
3.2.2 Is Patch Testing the "Gold Standard" to Investigate Patients with Allergic Contact Dermatitis? 3.3 Patch Test Units
3.3.1 Nonchamber Patch Tests
3.3.2 Chamber Patch Tests
3.3.2.1 Finn Chambers
3.3.3 Plastic Square Chambers
3.3.3.1 IQ Square Chambers Chemotechnique
3.3.3.2 allergEAZE Chambers SmartPractice
3.3.3.3 allergEAZE Patch Test Chamber
3.3.3.4 allergEAZE Clear Patch Test Chamber
3.3.4 Reinforcement of Patch Test Units
3.4 A General Overview of Allergens
3.4.1 Allergens
3.4.2 Bioavailability of Allergens
3.4.3 Quality Control of Allergens
3.4.4 Appropriate Amounts of Petrolatum to Be Applied at Patch Testing

Summary: This book is a compendium of tips on many different aspects of patch testing based on the recommendations of the International Contact Dermatitis Research Group (ICDRG), which is the reference group for all dermato-allergologists. It is intended to complement the book Patch Testing and Prick Testing: A Practical Guide by J.-M. Lachapelle and H. Maibach, which is an official publication of the ICDRG now in its third edition. Among the wide variety of topics covered are pitfalls, legal aspects, patch testing with ultrasonic bath extracts, the role of patch testing in occupational contact dermatitis and atopic dermatitis, semi-open tests, the implications of a negative test, patch testing validity, selection of extra allergens and patch testing in the tropics. Many illustrations are included and all information is completely up-to-date. This book will be of value to all practicing dermatologists.

Summary: This practical case-based book assists clinicians in the evaluation and treatment of patellofemoral patients by reviewing critical elements for assessment and presenting clinical scenarios in which different experts provide their recommendations for treatment. Subdivided in 6 parts it explores the joints anatomy and mechanics, as well as case-based evaluation and treatment of patellofemoral instability, arthritis and chondrosis, traumatic injuries and degenerative tendinopathies. Moreover, the closing part offers an overview of the latest advances and future developments. Written in collaboration with ISAKOS, this book offers a valuable guide for orthopedists and sports medicine treating common and complex injuries of this joint.

Contents:
I Patellofemoral anatomy, mechanics and evaluation
1 Patellofemoral anatomy and mechanics
2 Patient and family history in the evaluation of patellofemoral patients
3 Examination of patients with patellofemoral symptoms
4 Imaging evaluation of patients with patellofemoral symptoms
5 Principles of prevention and rehabilitation for patellofemoral - Christopher Powers
6 Newest surgical treatments for patellofemoral osteochondral lesions
II Case based evaluation and treatment of patellofemoral patients
7 The pediatric patient with open physes: case 11 year old girl with dysplasia
8 Adolescent patient with closed physes, mild dysplasia and malalignment: case 15 year old girl case presentation, and commentary and treatment recommendations by international surgeons
9 Young male soccer player with second dislocation, closed physes, normal trochlea 19 year old
10 21 year old male with alta, recurrent instability
11 19 year old girl with high tttg, trochlear dysplasia
12 25 year old with large chondral lesion, patellofemoral instability, tttg 15mm
13 35 year old with recurrent instability, chondrosis of patella and trochlea
III Patellofemoral pain. Chondrosis, and arthritis
14 19 year old with anterior knee pain, normal articular cartilage
15 22 year old with anterior knee pain, normal cartilage, mild alignment abnormalities
16 21 year old with patellofemoral pain and mal torsion of the lower limbs: place of derotation osteotomies
22 27 year old male, basketball, with central trochlear lesion
23 35 year old woman, lateral patella and trochlear chondrosis
24 55 year old, marginal osteophytes, general patellofemoral chondrosis
IV Traumatic injuries to the patellofemoral joint
25 Patellofemoral fracture, stellate, in 54 year old woman
26 Patella fracture of inferior pole, in 48 year old man
27 Quadriceps tendon rupture in 54 year old man
28 Patella tendon rupture in 37 year old man
V Degenerative tendinopathies of the patellofemoral joint
29 Osgood-Schlatters disease in a 12 year old
30 Patella tendinitis in a 21 year old basketball player
31 Patella tendinitis at Osgood-schlatters lesion of 32 year old
32 Quadriceps tendinitis in a 35 year old
VI Advances and the future treatment of patellofemoral disorders
33 Evidence based medicine
34 Biologic treatments.

Summary: A comprehensive and thorough selection of contributions from across the world, this book aims to review the current state-of-the-art in assessment and management of the patellofemoral joint. While featuring a wide range of surgical techniques for different pathologies, detailed attention is also devoted to conservative treatment and approaches involving mesenchymal stem cells, autologous chondrocyte implantation, platelet-rich plasma, and pulsed electromagnetic fields. Anatomy, clinical examination, and methods of evaluation are discussed, and individual chapters address important miscellaneous topics, including rehabilitation, complications of surgery, injuries in specific patient populations, and scoring systems. Though patellofemoral joint pathology is a frequent clinical problem, its management remains challenging for the orthopaedic surgeon. Conceived at the ISAKOS Congress held in Toronto in June 2013 as a small booklet, this work quickly turned into a major project involving more than 35 authors worldwide. The editors believe that this book will be of great value to orthopaedic doctors to improve understanding, diagnosis, and treatment of future patients.

Contents:
Morphogenesis of the patellofemoral joint
Anatomy of the patellofemoral
Anatomy and biomechanics of MPFL
Clinical examination of patellofemoral joint
Patellofemoral evaluation: an imagiological objective kinematic approach
MRI of patellofemoral joint
Gait analysis in patellofemoral disorder
Prevention of patellofemoral injuries
Patellofemoral syndrome
Patellofemoral instability
Patellar dislocation: pathomechanism and treatment
First-time traumatic patellar dislocation: a systematic review
Medial patellar instability
a little known cause of anterior knee pain
Non-operative treatment of patellofemoral joint
Surgical treatment of the patellofemoral joint: lateral release
MPFL repair for recurrent or traumatic patellar dislocation
Medial patellofemoral ligament reconstruction
Proximal realignment: medial plication
MPFL reconstruction based on graft tension change and anatomy
Elmslie-Trillat Procedure: a distal based procedure for patellar stabilization
Open proximal trochleaplasty (grooveplasty)
Sulcus-deepening trochleoplasty for the treatment of recurrent patellar dislocation with high-grade trochlear dysplasia
Role of rotational osteotomy in the treatment of patelofemoral dysfunction
New techniques for cartilage repair of the patella
Cartilage lesions of the patellofemoral joint: long term results after ACI
Role of mesenchymal stem cells in patellofemoral disorders
Prosthetic indications in patellofemoral osteoarthritis
Patellofemoral postoperative rehabilitation
Treatment of patellofemoral disorders in skeletally immature athletes
Treatment of patellofemoral dislocation in skeletally immature
Platelet-rich plasma for the treatment of symptomatic patellofemoral cartilage lesions
Pulsed electromagnetic fields for the treatment of symptomatic patellofemoral cartilage lesions of the knee
Matrix autologous chondrocyte implantation of the patella: from ACI to MACI to ICC
Patellofemoral joint pathology and sports
Patellofemoral injuries in soccer players
Complications of patellofemoral surgeries: prevention and management
Scores to evaluate patellofemoral joint
Conclusions.

Summary: Patellofemoral disorders are extremely prevalent in athletes and can lead to chronic pain, instability, weakness, and inconsistent or poor athletic performance. These disorders can be difficult to diagnose.Treatment options can vary depending upon several factors, including the sport andthe time during the sports season when the symptoms occur. Treatment also varies depending on the age of the patient and their competition level. The Patellofemoral Joint in the Athlete provides an extensive review of the physical examination, radiographic evaluation, differential diagnoses, and treatment options of common patellofemoral disorders, including patellar chondrosis, pain and instability. The contributors are nationally recognized experts in the patellofemoral joint that treat athletes of all ages and abilities. Appropriate for orthopedic surgeons, sports medicine physicians, rehabilitation physicians and physical therapists, this book is a comprehensive guide to the unique and sport-specific concerns of athletesof all ages and abilitieswith regard to the patellofemoral joint.

Contents:
Anatomy of the Patellofemoral Joint
Lateral Patella Dislocations: History, Physical Exam and Imaging
Rehabilitation Considerations for Non-Operative Management of Patellofemoral Conditions
Surgical Treatment of Patellar Instability in Skeletally Immature Athletes
Cartilage Restoration in the Patellofemoral Joint
MPFL Repair and Reconstruction
Tibial Tubercle Osteotomies
Patellofemoral Resurfacing Arthroplasty in the Active Patient
Overview of Surgical Decision Making.

Summary: This excellently illustrated book adopts an evidence-based approach to evaluate the efficacy of different techniques for the imaging and treatment of patellofemoral pain, instability, and arthritis. The aim is to equip practitioners with an informative guide that will help them to manage disorders of the patellofemoral joint by casting light on the many issues on which a consensus has been lacking. The opening chapters supply essential background information and explain the role of various imaging modalities, including radiography, CT, MRI, and bone scan. The various conservative and surgical treatment approaches for each of the three presentations - pain, instability, and arthritis - are then described and assessed in depth, with precise guidance on indications and technique. Postoperative management and options in the event of failed surgery are also evaluated. Throughout, careful attention is paid to the literature in an attempt to establish the level of evidence for each imaging and treatment method. The new edition has been thoroughly updated, with inclusion of additional chapters, in order to present the latest knowledge on biomechanics, diagnosis, surgical techniques, and rehabilitation.

Contents:
Classification and general considerations
Syndromes genetics
Detecting and addressing psychological factors
Imaging Analysis of Patella Instability Factors
MRI of the Patellofemoral Articular Cartilage
Computed Tomography and Arthro-CT Scan in Patellofemoral Disorders move to imaging
The Role of Tibial and Femoral Rotational Torsion abnormalities in the Treatment of Patellofemoral Dysfunction
Pathophysiology of Anterior Knee Pain
Patellofemoral Pain Syndrome
Non operative Treatment of PF pain
Is there a surgical Treatment of PF pain
Instability Factors Principals and Secondary for Instability
Influence of Risk Factors in the Natural History
Clinical Symptoms and Examination of Acute and Chronic Patellar Dislocations
First Time Dislocation: How to deal with it
Medial Side Patellofemoral Anatomy: Surgical Implications in Patellofemoral Instability
Is there any place for medial reefing in acture PF dislocation which technical procedure?
Medial Patellofemoral Ligament Reconstruction Indications and Surgical Technique
MPTL (Medial Patellotibial Ligament) Reconstruction
Tibial Tubercle Osteotomies
Indications and results
Tibial Tubercle Osteotomies
Techniques
AMZ
Tibial Tubercle Osteotomies
Techniques
Distalization
Tibial Tubercle Osteotomies
Techniques
Medialization
Tibial Tubercle Osteotomies Complications
Trochleoplasty Indications and results
Trochleoplasty Techniques: Arthroscopy
Trochleoplasty Techniques: Deepening Bereiter
Trochleoplasty Techniques: Deepening Lyon
Trochleoplasty Techniques: Elevating/lateral
Trochleoplasty Techniques: Recession Osteotomy
Trochleoplasty Techniques: Complications
Lateral Release of the Lateral Patellar Retunaculum
Lateral Retinaculum Lengthening
Lateral retinaculum reconstruction
Surgical Rehabilitation for select individual procedures
Designing a rehabilitation programme for PFJ rehabilitation
Complex primary cases
Obligatory dislocators in flexion
Is there an indication for Patella osteotomies
Is there an indication for correcting a valgus knee
Isolated Patellofemoral Osteoarthritis: Natural History and clinical Presentation
The Non-operative Treatment of Patellofemoral Arthritis
Techniques for cartilage restoration in pf joint
Isolated Patellofemoral unipolar pf cartilage lesions when to intervene
Partial Lateral Facetectomy
Isolated Patellofemoral Osteoarthritis: Prosthetic Indications
Patellofemoral disorders in skeletally immature patients
Specific procedures for pediatric dislocation
Mpfl techniques and constraints: what does this mean?
Patellar tendon shortening
Tibial tubercule procedure / old Osgood Schlatter
Femoral and tibial osteotomies
Epiphsiodesis : we already have limb lengthening.

Contents:
SECTION I: BACKGROUND AND ANATOMY
Historical perspective and importance of PFO
Embryology, Neonatal Circulation and Anatomy of PFO
Anatomical variations of Patent Foramen Ovale
Aging and Patent Foramen Ovale
SECTION II: METHODS AND TECHNIQUES FOR DETECTION AND CHARACTERIZATION OF PFO
Echocardiographic detection and transcranial Doppler quantification of right-to-left shunting.
ICE: intra-procedural evaluation and guidance during closure of PFO
A Comparison of Methods to Detect and Quantitative PFO: TCD, TTE, ICE and TEE
Angiographic evaluation for PFO and Pulmonary AVMs
SECTION III: PFO AND CLINICAL SYNDROMES
An Overview of Clinical Syndromes (Keeping The Heart In Mind)
The Association of Patent Foramen Ovale and Migraine Headache
Current Patient Management Issues, Clinical Trial Design Challenges, and the Pathway Forward
Patent foramen ovale and divers
Orthodeoxia and Platypnea
Obstructive Sleep Apnea and Patent Foramen Ovale
PFO and Various Types of Surgery
When a PFO is Discovered Incidentally
SECTION IV: CLOSURE METHODS
The GORE Septal Occluder
The novel PFO specific closure devices: Why did they fail?
Optimal device for children and closure indications in pediatric population
Occlutech, PFM, Lifetech, and other new devices. What?s on the horizon?
Complications of PFO Closure
SECTION V: STATISTICAL METHODS, TRIALS AND TRIBULATIONS
Device Closure of Patent Foramen Ovale or Medical Therapy for Cryptogenic Stroke: The CLOSURE I Trial
The Gore REDUCE Clinical Study
The PC Trial: An Effective Treatment Not Demonstrating Effective Power
From FDAs point of view: What is needed to move PFO closure for stroke prevention forward?
The Medical Device Manufacturer?s Perspective ? W.L. Gore & Associates, Inc
PFO-Patient?s Perspective
Clinical Trials to Assess the Relationship between Patent Foramen Ovale and Migraine Headaches
Do We Need More PFO Trials: Hypercoaguable Syndromes, Obstructive Sleep Apnea, and Arrhythmias
SECTION VI: DIFFICULTIES/OBSTACLES IN STARTING PFO CLOSURE PRACTICE
Obstacles in Starting a PFO Closure Program. How I Did It
Developing a successful integrated PFO closure program.

Summary: This textbook provides a one-stop reference resource and guide for nurses interested in advancing their careers. It addresses self-assessment, goal setting and self-discipline, as well as academic paths and non-academic career paths, and includes two chapters on strategic path development, covering internal motivation, risk taking, work--life balance, work environment, networking, professional membership and mentorship. Lastly, the book discusses professional growth topics such as civility, burnout, professional development and "keeping informed," and explores specific professionalism topics like professional behavior, ethics, social media and executive presence. Intended for nurses at any level, this textbook examines topics relevant to today's nursing professionals and offers guidance on building a successful nursing career. It also helps student nurses create a path for their career and professional growth, both during their training program and beyond.

Contents:
Preface
Introduction
Section I. Chapter 1: Self-Assessment
Chapter 2: Goal Setting and Self Discipline
Section II. Chapter 3: Professional Nursing Career Paths: the non-academic path
Chapter 4: Professional Nursing Career Paths: the academic path
Section III. Chapter 5: Charting YOUR Career Path: internal strategies
Chapter 6: Charting YOUR Career Path: external strategies
Chapter 7: The basics of Professional Growth
Chapter 8: Ensuring Continued Professional Growth
Chapter 9: Professionalism.

Contents:
1. Epigenetic regulation
2. HIV-induced epigenetic alterations in host cells
3. Epigenetic alterations in Epstein-Barr virus-associated diseases
4. Epigenetic dysregulation in virus-associated neoplasms
5. Epigenetic alterations induced by bacterial lipopolysaccharides
6. Patho-epigenetics of infectious diseases caused by intracellular bacteria
Index.

Contents:
Part 1. General disease pathogenesis
Part 2. Organ systems pathophysiology
Part 3. Diagnostic pathology
Part 4. Techniques in experimental pathology.

Contents:
Evaluation of genetic diversity of Candida spp. and Klebsiella spp. isolated from the denture plaque of COPD patients
Particulate matter in the air of the underground chamber complex of the Wieliczka Salt Mine Health Resort
Comparison of thymic stromal lymphopoietin concentration in various human biospecimens from asthma and COPD patients measured with two different ELISA kits
Prevalence of Neisseria meningitidis carriage with identifcation of serogroups and genogroups in professional soldiers
Bacteriological assessment of pneumonia caused by gram-negative bacteria in patients hospitalized in intensive care unit
Bacteriological assessment of pneumonia caused by gram-negative bacteria in patients hospitalized in intensive care unit
Whooping cough in adults: a series of severe cases
Limited clinical significance of dimeric form of pyruvate kinase as a diagnostic and prognostic biomarker in non-small cell lung cancer
Clostridium Difficile infection due to pneumonia treatment: mortality risk models
Predictors of progression in IgA nephropathy in childhood.

Contents:
Evolution of immunity and pathogens
A host-pathogen interaction reduced to first principles: Antigenic variation in T. brucei
Antigenic variation in Plasmodium falciparum
Polymorphic mucin-like proteins in Schistosoma mansoni, a variable antigen and a key component of the compatibility between the schistosome and its snail host
Fibrinogen-related proteins (FREP) in mollusks
Somatic and germline diversification of a putative immunoreceptor within one phylum: Dscam in arthropods
An immune effector system in the Protochordate gut sheds light on fundamental aspects of vertebrate immunity
Variable lymphocyte receptors: a current view
Antibody repertoire in fish
Unique features of fish immune repertoires: particularities of the adaptive immunity within the largest group of vertebrates
The evolution and structure of atypical T cell receptors
Diversification of the primary antibody repertoire by AID-mediated gene conversion
Antibody isotype switching in vertebrates.

Summary: "A sweeping look at how the major transformations in history-from the rise of Homo sapiens to the birth of capitalism-have been shaped not by humans but by germs. According to the accepted narrative of progress, humans have thrived thanks to their brains and brawn, collectively bending the arc of history. But in this revelatory book, professor Jonathan Kennedy argues that the myth of human exceptionalism overstates the role that we play in social and political change. Instead, it is the humble microbe that wins wars and topples empires. Drawing on the latest research in fields ranging from genetics and anthropology to archaeology and economics, Pathogenesis takes us through 60,000 years of history, exploring eight major outbreaks of infectious disease that have made the modern world. Bacteria and viruses were protagonists in the demise of the Neanderthals, the growth of Islam, the transition from feudalism to capitalism, the devastation wrought by European colonialism, and the evolution of the United States from an imperial backwater to a global superpower. Even Christianity rose to prominence in the wake of a series of deadly pandemics that swept through the Roman Empire in the second and third centuries: Caring for the sick turned what was a tiny sect into one of the world's major religions. By placing disease at the center of his wide-ranging history of humankind, Kennedy challenges some of the most fundamental assumptions about our collective past-and urges us to view this moment as another disease-driven inflection point that will change the course of history. Provocative and brimming with insight, Pathogenesis transforms our understanding of the human story"-- Provided by publisher.

Contents:
Paleolithic Plagues
Neolithic Plagues
Ancient Plagues
Medieval Plagues
Colonial Plagues
Revolutionary Plagues
Industrial Plagues
Plagues of Poverty.

Contents:
Part I. Pathogenesis
Chapter 1. Is IgA nephropathy the same disease/a homogenous disease?
Chapter 2. Genetic variations of IgA nephropathy
Chapter 3. Is IgA nephropathy a familial or sporadic disease?
Chapter 4. Heterogeneity of GdIgA1
Chapter 5. Differences of histological classification between the Japanese guideline and the Oxford classification
Chapter 6. Podocyte injury and the role of megalin
Chapter 7. Complement activation
Part II. Treatment
Chapter 8. How different are the current understandings of treatments for IgA nephropathy?
Chapter 9. Differences in etiology and treatment in China
Chapter 10. Differences in etiology and treatment in Korea
Chapter 11. Differences in etiology and treatment in Japan
Chapter 12. The VALIGA study: Differences in treatment approaches within the EU
Chapter 13. Differences in etiology and treatment in Scandinavian countries
Chapter14 The Implication of the KDIGO Clinical Practice Guidelines on management of IgA Nephropathy
Chapter15 Japanese Clinical Practice Guidelines for IgA Nephropathy: Difference from KDIGO Guidelines
Chapter16 Limitations of RAS blockade in IgA nephropathy
Chapter17 What is the goal for proteinuria in IgA nephropathy?
Chapter 18. Rationale of tonsillectomy and steroid pulse therapy (TSP): Is it race dependent?
Chapter 19. Is tonsillectomy a possible treatment for IgA nephropathy from RCT?
Chapter 20. Is tonsillectomy a possible treatment for IgA nephrology from a retrospective analysis?.

Summary: This book, written by experts from across the world, provides comprehensive coverage of acne and rosacea, focusing in particular on pathogenesis and treatment but also considering clinical aspects, prognostic factors, and impacts on quality of life. Both standard knowledge and important, clinically relevant insights that have emerged over the past decade are presented with the goal of assisting the reader in understanding these diseases and improving treatment outcome. It is explained how high-level research has recently given rise to a variety of new concepts in etiology and treatment, and emerging trends are also discussed. The book is in a reader-friendly format that highlights core messages with a very practical and clinical focus. Pathogenesis and Treatment of Acne and Rosacea will be an indispensable reference for all physicians who care for patients with acne or rosacea and for scientists working in the field.

Contents:
The Sebaceous Gland Through the Centuries: A Difficult Path to Independence
Embryology of the Pilosebaceous Unit
Molecular Aspects of Sebaceous Differentiation
Anatomy of the Sebaceous Gland
Sebum and Sebaceous Lipids
Experimental Models of the Sebaceous Gland
Acne Epidemiology and Socioeconomic Aspects
Acne Pathogenesis: What We Have Learned Over the Years
The Role of Hyperkeratinization
The Role of the Sebaceous Gland
The Role of Bacteria
Inflammation in Acne
A New Concept of Acne Pathogenesis
Acne and Genetics
Acne and Androgens
Acne and Inflammation
Acne and Neuropeptides
Acne and Bacteria
The Acne Biofilm
The Evidence Supporting a Link Between Acne and Nutrition
Acne and Smoking
Antimicrobial Peptides in Acne
Acne and Antimicrobial Lipids
Natural and Artificial Suntanning
Acne and Environmental Pollution (Chloracne)
Myths and Beliefs of Acne Pathogenesis: Diet, Smoking, Hygiene
Understanding Acne as a Chronic Disease
Clinical Aspects of Acne Vulgaris
Clinical Aspects of Acne Fulminans
Childhood Acne
Congenital Adrenal Hyperplasia and Acne in the Male Patients
Adult Acne
Drug-Induced Acne
Body-Builder Acne
Acne Cosmetica
Acne in Persons with Dark Skin
Acne and Heredity
Acne Neonatorum
Serum Androgens
Body Mass Index
Sebum Secretion, Skin Type, and pH
Lipids in Serum and Sebum
The Leeds Acne Grading Technique
Evaluation of Clinical Severity by Acne Grading and Lesion Counting
Modern Technology for Imaging and Evaluation of Acne Lesions
Acne and Congenital Adrenal Hyperplasia
The Acne Genes
Vitamins and the Skin
Urinary Hormone Analysis in Acne
Laboratory Evaluations in Acne
Evidenced-Based Treatment of Acne
The Difficult Acne Patient
Improving Compliance with Acne Therapy
Keratolytic Treatment
Topical Antibiotics
Benzoyl Peroxide
Topical Retinoids
Azelaic Acid
Emerging Acne Treatments
Oral Antibiotics
The Antibiotic Resistance in Acne
Prescribing Oral Isotretinoin: The European Approach
Oral Isotretinoin: The US Approach
Hormonal Therapy for Acne
Less Common Treatments
Risk Factors of Acne Relapse
Acne Maintenance Therapy
Cosmetics and Cleansers in Acne
Chemical Peeling in Acne
Lasers and Phototherapy in Acne
Treatment of Acne Scarring
Concepts of Future Acne Treatment
Acne and Quality of Life
Instruments of Measurement of Quality of Life in Acne
The SAHA Syndrome
The Polycystic Ovary Syndrome and Acne
The SAPHO Syndrome
The PAPA Syndrome
Acne in Transplantation Patients
Rosacea: The State of the Art
The Vascular Concept
Rosacea and Neuropeptides
Rosacea and Demodex folliculorum
The Role of Adenosine Triphosphate in the Pathogenesis of Rosacea: An Explanation for the Mode of Action of Tetracyclines for the Treatment of Rosacea
Standard Grading System for Rosacea
Classical Clinical Presentations of Rosacea
Rhinophyma: A Variation of Rosacea?
Ocular Rosacea
Childhood Rosacea
Differential Diagnosis of Rosacea
A Treatment Strategy for Rosacea
Topical Treatment of Rosacea
Systemic Treatment of Rosacea
Laser and Light Therapy of Rosacea
Nonclassical Treatments
Cosmetics in Rosacea
Treatment of Rhinophyma
The Future of Rosacea Treatment
Impact of Rosacea on Quality of Life.

Summary: This book provides comprehensive coverage of current topics in idiopathic scoliosis (IS). A three-dimensional deformity of the spine, the condition is characterized by lateral curvature combined with vertebral rotation. The primary lesion, however, lies in the median sagittal plane, taking the form of a lordosis. Although the clinical manifestations of scoliosis have been well documented, its cause and pathogenesis have not yet been determined. Research into what causes IS has focused on the structural elements of the spine, spinal musculature, collagenous structures, the endocrine system, the central nervous system, and genetics. Results of these studies have brought about a new perception of IS epiphenomena, but the main cause of IS remains unknown. Recently, several investigators have produced new hypotheses regarding the cause of IS using the developing techniques of genetics, biochemistry, and neurology. This book is a review of the various causative factors thus far proposed for IS and an introduction to the directions in which research is heading to determine the primary cause of IS.

Summary: This comprehensive source on the pathogenic origins of neuropathic pain covers the detailed molecular bases of the currently known neuropathies as classified by their pathogenic origins. Filling a critical need, this book fills the need for a resource on a syndrome that demands improved understanding by clinicians and researchers alike so that treatment options for patients are not categorically limited to a pill or a needle. If the clinician understands the origins of a patients' neuropathic pain, they can work cooperatively toward improving it with tailored therapies that don't create societal diseconomies and that ultimately are effective in helping patients. The book presents in detail the molecular bases of some currently known neuropathies by their pathogenetic origins, allowing clinicians to tailor more specific and more effective treatment regimens for their patients. For basic researchers, this book is a general resource to better direct research on neuropathy-specific molecular mechanisms. The improved understanding of the pathogenesis of neuropathic pain can then be used to develop more specific and more effective manipulations of these pathways.

Contents:
Introduction
Transitional Neuropathy: Chronification of Acute Pain
Diabetic Neuropathy
Complex Regional Pain Syndrome (CRPS)
Autoimmune Disease-Related Neuropathy
Methylation Disorder Neuropathy
Alcohol-Related Neuropathy
Perfusion-Related Neuropathy
Uremic Neuropathy
Chemotherapy Induced Neuropathy
Antibiotics and Antifungals
Miscellaneous
Treatment
Conclusion.

Summary: Pathological Myopia is a major cause of severe vision loss worldwide. The mechanisms for vision loss include cataract, glaucoma, retinal detachment, and above all, degeneration of the macula within the posterior staphyloma. Pathological Myopia is one of the only current books to specifically address this disease and discusses recent developments in imaging technologies and various approaches to treatments, such as laser photocoagulation, photodynamic therapy, pharmaco-therapeutic injections in the vitreous, and surgery. Complete with high-quality color images, this book is written and edited by leaders in the field and is geared towards ophthalmologists, including residents and fellows in training, glaucoma and cataract specialists, and vitreoretinal macula experts.

Contents:
1. Myopia: A Historical Perspective
2. Genes involved in the development of myopia
3. Epidemiology of Myopia
4. Animal Models of Experimental Myopia: Limitations and Synergies With Studies on Human Myopia
5. The Sclera and its Role in Regulation of the Refractive State
6. Public Health Impact of Pathologic Myopia
7. Update on the Pathology of Pathologic Myopia
8. The Sclera and Induced Abnormalities in Myopia
9. The Choroid
10. The Optic Nerve in High Myopia
11. Vitreous Changes
12. Staphyloma, Part 1
13. Staphyloma, Part 2
14. Myopic Chorioretinal Atrophy
15. Choroidal Neovascularization
16. Myopic Macular Retinoschisis
17. Peripheral Retinal Abnormalities
18. Retinal Detachment
19. Glaucoma in Myopia
20. Myopic Optic Neuropathy
21. Special Considerations for Cataract Surgery in the Face of Pathologic Myopia
22. Ocular Motility Abnormalities
23. Myopia: Ocular and Systemic Disease
24. Prevention of Myopia
25. Sclera-targeted Therapies for Pathologic Myopia.

Summary: Pathologic Myopia is a major cause of severe vision loss worldwide. The mechanisms for vision loss include cataract, glaucoma, retinal detachment, and above all, myopic maculopathy within the posterior staphyloma. The first edition of Pathologic Myopia is one of the only current books to specifically address this disease and discusses recent developments in imaging technologies and various approaches to treatments, such as laser photocoagulation, photodynamic therapy, pharmaco-therapeutic injections in the vitreous, and surgery. This new edition is a timely update to the standard reference in the field, with new chapters on advanced refractive error correction, genetics, developing a classification system, and special surgical approaches for pathologic myopia. Complete with even more high-quality color images and informative tables, this book is written and edited by leaders in the field and is geared towards ophthalmologists, including residents and fellows in training, glaucoma and cataract specialists, and vitreoretinal macula experts.

Contents:
Section 1. Basic Science of Pathologic Myopia.
Chapter 1. Myopia: A Historical Perspective
Chapter 2. Definition of pathologic myopia (PM)
Chapter 3. Epidemiology of Myopia, High Myopia and Pathological Myopia
Chapter 4. Genetics of Pathologic Myopia
Chapter 5. Public Health Impact of Pathologic Myopia
Chapter 6. Animal Models of Experimental Myopia: Limitations and Synergies with Studies on Human Myopia
Chapter 7. The Sclera and its Role in Regulation of the Refractive State
Section 2 - Ocular Changes in the Development of Pathologic Myopia.
Chapter 8. Update on the Pathology of Pathological Myopia
Chapter 9. The Sclera and Induced Abnormalities in Myopia
Chapter 10. The Choroid Fin
Chapter 11. Theories of Myopization: Potential Role of a Posterioly Expanding Bruch's Membrane
Chapter 12. The Optic Nerve Head in High Myopia / Abnormalities of the Intrapapillary and Parapapillary Region
Chapter 13. Vitreous Changes in Myopia
Chapter 14. Ultra-widefield imaging of vitreous in pathologic myopia
Section 3- Sequella of Pathologic Myopia and Their Potential Treatments.
Chapter 15. Staphyloma I
Chapter 16. Staphyloma II
Chapter 17. Overview of OCT-based classification of macular lesions due to pathologic myopia
Chapter 18. Myopic Maculopathy
Chapter 19. Choroidal Neovascularization
Chapter 20. Myopic Macular Retinoschisis
Chapter 21. surgical approaches for complications of PM
Chapter 22. Peripheral Retinal Abnormalities
Chapter 23. Retinal Detachment
Chapter 24. Glaucoma in Myopia
Chapter 25. Myopic Optic Neuropathy
Chapter 26. Special Considerations for Cataract Surgery in the Face of Pathologic Myopia
Chapter 27. Ocular Motility Abnormalities
Chapter 28. Ocular and Systemic Disease
Section 4 - Treatment of pathologic myopia.
Chapter 29. Prevention of myopia progression in children and adolescents
Chapter 30. OPTICAL METHODS TO SLOW THE PROGRESSION OF MYOPIA
Chapter 31. Sclera-targeted therapies for pathologic myopia.

Contents: <br/
>1. T. Die Pathologie und Therapie der Sterilität beim Manne.

Summary: Calcium ions represent Mother Nature's "ion-of-choice" for regulating fundamental physiological functions, as they initiate a new life at the time of fertilization and guide subsequent developmental and physiological functions of the human body. Calcium channels, which act as gated pathways for the movement of calcium ions across the membranes, play a central part in the initiation of calcium signals, and defects in calcium channel function have been found to result in a plethora of human diseases, referred to as the calcium channelopathies. Pathologies of Calcium Channels brings together leading international experts to discuss our current understanding of human diseases associated with the various calcium channels, from their molecular basis to potential future therapeutic targeting of calcium channels.

Contents:
Part I. Pathologies of Voltage-Gated Calcium Channels
Part II. Pathologies of Transient Receptor Potential Channels
Part III. Pathologies of Ligand-Gated Calcium Channels.

Contents: <br/
>1. Die Funktionsstörungen des Herzens, der Gefässe und des Blutes.

Summary: This is a classic description and classification of pelvic deformities.

Contents:
1. Bd. Allgemeines, Missbildungs-, Assimilations- und Zwergbecken, riesen-Rachitisbecken und Dimensional-Anomalien ([1900]-1904. vii, [1], 707 p., incl. 216 ill., tables)
2. Bd. Osteomalaciebecken, ostitische und synostotische Becken, Exostosen-, Neubildungs-, Fractur- und Lacerationsbecken ([1908]-1910. vi, [2], 583 p. incl. 175 ill., tables)
3. Bd. Abnorme Beckenformen infolge von Anomalien der Wirbelsäule, der unteren Extremitäten und des Nervensystems (1900-1912. v, [1], 696 p. incl. 182 ill., tables).

Contents:
Disease and the genome : genetic, developmental and neoplastic disease
Cell injury, death and aging and the body's response
Environmental injury
Clinical practice : anatomic pathology
Clinical practice : molecular pathology
Clinical practice : laboratory medicine and patient care
The vascular system
Pulmonary pathology
Pathology of the gastrointestinal tract
Pathology of the liver, gallbladder and extrahepatic biliary tract
Pathology of the pancreas
Pathology of medical renal disease
Urologic pathology of the lower urinary tract and male gu system
Hematopathology
Basic principles of clinical endocrinology
Breast pathology
The female reproductive tract
Soft tissue and bone pathology
Neuromuscular pathology
Pathology of the skin
Pathology of the nervous system.

Summary: "We have continued to center our presentations around case studies designed to emphasize the role of the pathologist in the team that provides patient care, examining the role of anatomic, clinical, and molecular pathologists in that multi-membered group both in dedicated chapters and in descriptions of the pathology of specific organ systems."--Preface

Contents:
1. Cancer and the Genome
2. Cell Injury, Cell Death, and Aging
3. Hemostasis and Thrombosis --4. Environmental Injury
5. Clinical Practice: Anatomic Pathology
6. Clinical Practice: Molecular Pathology
7. Clinical Practice: Laboratory Medicine and Patient Care
8. The Cardiovascular System
9. Pulmonary Pathology
10. Pathology of the Gastrointestinal Tract
11. Pathology of the Liver, Gallbladder, and Extrahepatic Biliary Tract
12. Pathology of the Pancreas
13. Pathology of Medical Renal Disease
14. Urologic Pathology of the Lower Urinary Tract, Male GU System, and Kidney
15. Hematopathology
16. Pathology of the Endocrine System
17. Breast Pathology
18. The Female Reproductive Tract
19. Soft Tissue and Bone Pathology
20. Neuromuscular Pathology
21. Pathology of the Skin
22. Pathology of the Nervous System

Contents:
I, Introduction :
1. Introduction to concepts of pathology
2. Behavioral, social, and environmental factors contributing to disease and dysfunction
3. The psychosocial-spiritual impact on health care
4. Environmental and occupational medicine
5. Problems affecting multiple systems
6. Injury, inflammation, healing, and repair. II, Clinical medicine :
7. The immune system
8. Infectious disease
9. Oncology
10. The integumentary system
11. The endocrine and metabolic systems
12. The cardiovascular system
13. The lymphatic system
14. The hematologic system
15. The respiratory system
16. The gastrointestinal system
17. The hepatic, pancreatic, and biliary systems
18. The renal and urologic systems
19. The male genital/reproductive system
20. The female genital/reproductive system
21. Transplantation. III, Pathology of the musculoskeletal system :
22. Introduction to pathology of the musculoskeletal system
23. Genetic and developmental disorders
24. Metabolic disorders
25. Infectious diseases of the musculoskeletal system
26. Musculoskeletal neoplasms
27. Soft tissue, joint, and bone disorders. IV, Pathology of the nervous system :
28. Introduction to central nervous system disorders
29. Infectious disorders of the central nervous system
30. Central nervous system neoplasms
31. Degenerative diseases of the central nervous system
32. Stroke
33. Traumatic brain injury
34. Traumatic spinal cord injury
35. Cerbral palsy
36. Seizures and epilepsy
37. Headache
38. Vestibular disorders
39. The peripheral nervous system
40. Laboratory tests and values.

Contents:
Basic Principles of Patho-Epidemiology
The Intersection of Epidemiology and Pathology
Introduction to Histology
Introduction to Pathology
Basic Techniques in Molecular Pathology
Introduction to Cancer Epidemiology
Cancer Screening
Molecular and Genetic Epidemiology of Cancer
Bioinformatic Analysis of Epidemiological and Pathological Data
Cancer Types
Epidemiology of Prostate Cancer
Pathology and Molecular Pathology of Prostate Cancer
Epidemiology of Breast Cancer
Pathology and Molecular Pathology of Breast Cancer
Epidemiology of Ovarian and Endometrial Cancer
Pathology and Molecular Pathology of Uterine and Ovarian Cancers
Brain Tumors
Epidemiology
Pathology and Molecular Pathology of Brain Cancer
Epidemiology of Renal Cell Carcinoma
Pathology and Molecular Pathology of Renal Cancer
Epidemiology of Lung Cancer
Pathology and Molecular Pathology of Lung Cancer
Epidemiology of Colorectal Cancer
Pathology and Molecular Pathology of Colorectal Cancer
Epidemiology of Hepatocellular Carcinoma
The Pathology and Molecular Pathology of Hepatocellular Carcinoma
Epidemiology of Pancreatic Cancer
Pathology and Molecular Pathology of Pancreatic Cancer
Epidemiology of Bladder Cancer
Bladder Cancer
Epidemiology of Hematologic Malignancies
Pathology and Molecular Pathology of Hematologic Malignancies
Epidemiology of Melanoma
Pathology and Molecular Pathology of Melanoma.

Contents:
An Introduction to Pathology Techniques / Elizabeth McInnes
Recording Pathology Data / Cheryl L Scudamore
General Pathology and the Terminology of Basic Pathology / Elizabeth McInnes
Common Spontaneous and Background Lesions in Laboratory Animals / Elizabeth McInnes
Target Organ Pathology / Elizabeth McInnes
Clinical Pathology / Barbara Beust
Adversity: A Pathologist's Perspective / Bhanu Singh
Limitations of Pathology and Animal Models / Natasha Neef.

Summary: The third edition of Pathology of Asbestos-Associated Diseases builds on the success of the previous editions by fully updating knowledge on diagnostic and epidemiologic aspects and presenting important new insights derived from new epidemiologic studies and animal studies. Background information is first provided on the mineralogy of asbestos, occupational and environmental exposure, and asbestos bodies. The various diseases associated with asbestos exposure are then considered in turn, with detailed description and illustration of pathologic features as well as extensive discussion of etiology, epidemiology, differential diagnosis, treatment, and prognosis. Further chapters are devoted to cytopathology, experimental models of disease, and analysis of tissue mineral fiber content. In addition, the medicolegal issues relating to asbestos-associated diseases are analyzed from the point of view of both the plaintiff and the defendant. This book will be an essential reference for pathologists and an invaluable source of information for pulmonologists, radiologists, and occupational medical practitioners.

Contents:
Part I: Introductory Chapters
Chapter 1. Gross Prosection of Melanocytic Lesions
Chapter 2. Histopathologic Staging and Reporting of Melanocytic Lesions
Chapter 3. Clinicopathologic Correlation in Melanocytic Lesions
Chapter 4. Anathema or Useful? Application of Immunohistochemistry to the Diagnosis of Melanocytic Lesions
Chapter 5. Applications of Additional Techniques to Melanocytic Pathology
Part 2: Diagnostic Challenges
Chapter 6. Spitz Nevus versus Spitzoid Melanoma
Chapter 7. Halo Nevus versus Melanoma with Regression
Chapter 8. Nevoid Malignant Melanoma versus Melanocytic Nevus
Chapter 9. Dysplastic Nevi versus Melanoma
Chapter 10. Blue Nevus versus Pigmented Epithelioid Melanocytoma
Chapter 11. Recurrent Melanocytic Nevus versus Melanoma
Chapter 12. Neurothekeoma versus Melanoma
Chapter 13. Melanoma in situ versus Paget?s Disease
Chapter 14. Desmoplastic Nevus versus Desmoplastic Melanoma
Chapter 15. Cutaneous Metastatic Melanoma versus Primary Cutaneous Melanoma
Chapter 16. Acral Nevus versus Acral Melanoma
Chapter 17. Capsular (Nodal) Nevus versus Metastatic Melanoma
Index.

Summary: This book covers the full range of pathologic conditions encountered during childhood and youth, including tumors and tumor-like conditions of all organ systems, with direct links to developmental biology pathways and genetics. It provides a user-friendly road map to the main diagnostic criteria and combines an organ-related approach with an explanation of the diagnostic approaches to various specific diseases and syndromes, including sequential segmental analysis of congenital heart disease. More than 1000 new full-color macro- and microphotographs using more than 500 multi-photographic panels are included to provide a realistic basis for comparison macroscopically and under the lens, and summarizing tables highlight key information in the concise form required for at-a-glance review. Pathologists will find the book very helpful when signing out complex and challenging cases, and it will also prove invaluable for exam preparation and continuing medical education.

Contents:
Cardiovascular System
Lower Respiratory Tract
Gastrointestinal Tract
Liver
Pancreas, Gallbladder, and Extrahepatric Biliary System
Kidney, Pelvis, and Ureter
Lower Urinary and Male Genital System
Female Genital System
Breast
Hemato-Lymphoid System
Endocrine System
Soft Tissue
Arthro-Skeletal System
Head & Neck
Central Nervous System
Peripheral Nervous System
Skin
Placenta, Abnormal Conception, and Prematurity. .