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  • Book
    edited by Zahid Amin, Jonathan M. Tobis, Horst Sievert, John D. Carroll.
    Contents:
    SECTION I: BACKGROUND AND ANATOMY
    Historical perspective and importance of PFO
    Embryology, Neonatal Circulation and Anatomy of PFO
    Anatomical variations of Patent Foramen Ovale
    Aging and Patent Foramen Ovale
    SECTION II: METHODS AND TECHNIQUES FOR DETECTION AND CHARACTERIZATION OF PFO
    Echocardiographic detection and transcranial Doppler quantification of right-to-left shunting.
    ICE: intra-procedural evaluation and guidance during closure of PFO
    A Comparison of Methods to Detect and Quantitative PFO: TCD, TTE, ICE and TEE
    Angiographic evaluation for PFO and Pulmonary AVMs
    SECTION III: PFO AND CLINICAL SYNDROMES
    An Overview of Clinical Syndromes (Keeping The Heart In Mind)
    The Association of Patent Foramen Ovale and Migraine Headache
    Current Patient Management Issues, Clinical Trial Design Challenges, and the Pathway Forward
    Patent foramen ovale and divers
    Orthodeoxia and Platypnea
    Obstructive Sleep Apnea and Patent Foramen Ovale
    PFO and Various Types of Surgery
    When a PFO is Discovered Incidentally
    SECTION IV: CLOSURE METHODS
    The GORE Septal Occluder
    The novel PFO specific closure devices: Why did they fail?
    Optimal device for children and closure indications in pediatric population
    Occlutech, PFM, Lifetech, and other new devices. What?s on the horizon?
    Complications of PFO Closure
    SECTION V: STATISTICAL METHODS, TRIALS AND TRIBULATIONS
    Device Closure of Patent Foramen Ovale or Medical Therapy for Cryptogenic Stroke: The CLOSURE I Trial
    The Gore REDUCE Clinical Study
    The PC Trial: An Effective Treatment Not Demonstrating Effective Power
    From FDAs point of view: What is needed to move PFO closure for stroke prevention forward?
    The Medical Device Manufacturer?s Perspective ? W.L. Gore & Associates, Inc
    PFO-Patient?s Perspective
    Clinical Trials to Assess the Relationship between Patent Foramen Ovale and Migraine Headaches
    Do We Need More PFO Trials: Hypercoaguable Syndromes, Obstructive Sleep Apnea, and Arrhythmias
    SECTION VI: DIFFICULTIES/OBSTACLES IN STARTING PFO CLOSURE PRACTICE
    Obstacles in Starting a PFO Closure Program. How I Did It
    Developing a successful integrated PFO closure program.
    Digital Access Springer 2015