Books

Contents:
Library construction for mutation identification by whole-genome sequencing / Harold E. Smith
Fundamentals of comparative genome analysis in caenorhabditis nematodes / Eric S. Haag and Cristel G. Thomas
Genetic methods for cellular manipulations in C. elegans / Menachem Katz
Fusion PCR method for expressing genetic tools in C. elegans / Yifat Eliezer and Alon Zaslaver
Transposon-assisted genetic engineering with Mos1- mediated single-copy insertion (MosSCI) / Christian Frøkjær-Jensen
Creating genome modifications in C. elegans using the CRISPR/Cas9 system / John A. Calarco and Ari E. Friedland
Observing and quantifying fluorescent reporters / Michael Hendricks
Microbial rhodopsin optogenetic tools : application for analyses of synaptic transmission and of neuronal network activity in behavior / Caspar Glock, Jatin Nagpal, and Alexander Gottschalk
Simultaneous optogenetic stimulation of individual pharyngeal neurons and monitoring of feeding behavior in intact C. elegans / Nicholas F. Trojanowski and Christopher Fang-Yen
High-pressure freeze and freeze substitution electron microscopy in C. elegans / Laura Manning and Janet Richmond
Electron tomography methods for C. elegans / David H. Hall and William J. Rice
Microfluidic devices for behavioral analysis, microscopy, and neuronal imaging in Caenorhabditis elegans / Ross C. Lagoy and Dirk R. Albrecht
Tracking single C. elegans using a USB microscope on a motorized stage / Eviatar I. Yemini and André E. X. Brown
Imaging system for C. elegans behavior / Matthew A. Churgin and Christopher Fang-Yen
Method for obtaining large populations of synchronized Caenorhabditis elegans dauer larvae / Maria C. Ow and Sarah E. Hall
Sampling and isolation of C. elegans from the natural habitat / Nausicaa Poullet and Christian Braendle
Primer on prototyping / Dylan Lynch and David Biron
Primer on quantitative modeling / Iulia Neagu and Erel Levine.

Summary: This book focuses on C-type lectin receptors, a newly emerging family of pattern-recognition receptors (PRRs) and a crucial part of the human innate immune system. Above all, the authors highlight these receptors' role in the recognition of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) - one of the first steps in responding to foreign and potentially dangerous structures in the human body. The respective chapters chiefly examine various C-type lectin receptors, their corresponding ligands, and signalling. In addition to offering immunologists and clinicians important insights from the latest research, they may also provide novel points of departure for future drug development.

Contents:
C-type lectin receptors in phagocytosis
C-type lectins in immunity to lung pathogens
Signalling C-type lectins in antifungal immunity
Dendritic cell immunoactivating receptor: an activating receptor for mycobacteria
myeloid C-type lectin receptors sensing tissue damage
3D structure and ligand recognition of C-type lectins
Mechanisms and Functions of CARD9 Signaling in the Innate Immune System.

Summary: "There are few disciplines as exciting and forward-looking as medicine. Unfortunately, however, many modern practitioners have lost sight of the origins of their discipline. A Cabinet of Ancient Medical Curiosities aspires to cure this lapse by taking readers back to the early days of Western medicine in ancient Greece and Rome. Quoting the actual words of ancient authors, often from texts which have never before been translated into English, J. C. McKeown offers a fascinating glimpse at the origins of surgery, gynecology, pediatrics, pharmacology, diet and nutrition, and many other fields of medicine. This book features hundreds of passages from Greek and Roman authors, with gentle guidance from McKeown, giving a vividly direct picture of the ancient medical world, a world in which, for example, a surgeon had to be strong-minded enough to ignore the screams of his patient, diseases were assumed to be sent by the gods, medicine and magic were often indistinguishable, and no qualifications were required before setting oneself up as a doctor." -- Provided by publisher.

Contents:
Medicine, religion, and magic
The doctor in society
Attitudes to doctors
Some famous doctors
Anatomy
Sex matters
Women and children
Preventative medicine
Prognosis and diagnosis
Particular ailments and conditions
Treatment and cures I
Treatment and cures II
General medicine
Respice finem.

Summary: This book outlines the interaction of cadmium with the proteome and signalling molecules of mammalian cells. Chapters from expert contributors cover topics such as cadmium chemical biology, membrane receptors and transporters for cadmium and cadmium complexes, and targets of cadmium toxicity. Students and researchers working in bioinorganic chemistry will find this book an important account.

Contents:
Membrane transport proteins and receptors for cadmium and cadmium complexes
The chemical biology of cadmium
Interactions of cadmium with signaling molecules
Cell organelles as targets of cadmium toxicity
Cadmium and its impact on genomic stability.

Summary: This volume focuses on cadmium (Cd) exposure, its effects on human health, the mechanism of Cd accumulation and the development of mitigation technologies. Further, it discusses clinical, epidemiological, agricultural, toxicological, and biochemical aspects of Cd pollution and presents recent biochemical studies on molecular mechanisms of Cd cytotoxicity and cellular transport as well as the mechanism of Cd-induced disturbances in phosphorus (P) metabolism. It also provides insights into the pathophysiology of itai-itai disease, a serious condition caused by Cd pollution. Cadmium -New Aspects in Human Disease, Rice Contamination, and Cytotoxicity- is a valuable resource for scientists involved in heavy metal toxicology, botanical sciences, and regulatory sciences. Addressing the features of Cd pollution in the past and in the present, as well as future perspectives, this is a must-have book for students, researchers and practitioners interested in global and local metal pollution.

Contents:
Section 1: Radiation effects and safety. Radiation bioeffects, risks, and radiation protection in medical imaging in children
Media. Magnetic resonance safety
Complications of contrast
Section 2: Head and neck. Part 1: Orbit. Embryology, anatomy, normal findings, and imaging techniques
Prenatal, congenital, and neonatal abnormalities
Orbit infection and inflammation
Orbital neoplasia
Part 2: Nose and sinuses. Nose and sinonasal cavities
Part 3: Ear and temporal bone. Embryology, anatomy, normal findings, and imaging techniques
Congenital and neonatal abnormalities
Infection and inflammation
Neoplasia
Part 4: Neck. Embryology, anatomy, normal findings, and imaging techniques
Prenatal, congenital, and neonatal abnormalities
Infection and inflammation
Neoplasia
Part 5: Thyroid and parathyroid. Thyroid and parathyroid
Section 3: Neuroradiology. Part 1: Cranium and face. Embryology, anatomy, normal findings, and imaging techniques
Prenatal imaging
Craniosynostosis, selected craniofacial syndromes, and other abnormalities of the skull
Neoplasms, neoplasm-like lesions, and infections of the skull
Part 2: Mandible. The mandible
Part 3: Skull and facial trauma. Traumatic lesions of the skull and face
Part 4: Brain. Embryology and brain development
Magnetic resonance spectroscopy and positron emission tomography
Diffusion-weighted magnetic resonance imaging: principles and implementation in clinical and research settings
Functional magnetic resonance imaging
Perfusion imaging and magnetoencephalography
Prenatal imaging
Neonatal brain injury
Congenital brain malformations
Hydrocephalus
Inherited metabolic and neurodegenerative disorders
Infection and inflammation
Pediatric brain neoplasms
Cerebrovascular disorders
Stroke
Neuroimaging in pediatric epilepsy
Trauma
Part 5: Vertebral column and spinal cord. Embryology, anatomy, and normal findings
Spinal cord imaging techniques
Prenatal imaging
Congenital abnormalities of the spine
Infections of the spine and spinal cord
Spinal tumor and tumorlike conditions
Vascular lesions
Trauma
Section 4: Respiratory system. Part 1. Overview. Embryology, anatomy and neonatal lung pathophysiology
Imaging techniques
Prenatal imaging and intervention
Part 2: Airway. Upper airway disease
Lower large airway disease
Part 3: Lungs. Congenital lung anomalies
Pulmonary infection
Neoplasia
Diffuse lung disease
Pulmonary manifestations of systemic disease
Part 4: Mediastinum. The mediastinum
Part 5: Chest wall, pleura, and diaphragm. The chest wall
The pleura
The diaphragm
Section 5: Heart and great vessels. Part 1: Overview. Introductory embryology
Cardiovascular anatomy and segmental approach to imaging of congenital heart disease
Part 2: Imaging techniques. Pediatric echocardiography
Chest radiography in pediatric cardiovascular disease
Pediatric cardiothoracic computed tomographic angiography
Magnetic resonance imaging for congenital heart disease
Pediatric cardiac catheterization and electrophysiology
Surgical considerations for congenital heart disease
Prenatal imaging and therapy of congenital heart disease
Part 3: Congenital and cardiovascular abnormalities. Abnormal pulmonary and systemic venous connections
Systemic to pulmonary arterial shunts
Left heart lesions
Right heart lesions
Conotruncal anomalies
Congenital anomalies of the thoracic great arteries
Coronary artery disease in children
Syndromes and chromosomal anomalies
Part 4: Acquired cardiovascular abnormalities. Myocardial, endocardial and pericardial diseases
Cardiac and pericardial tumors
Cardiovascular involvement by systemic diseases
Acquired diseases of the thoracic great vessels
Section 6: Gastrointestinal system. Part 1: Overview. Embryology, anatomy, and normal findings
Imaging techniques
Prenatal gastrointestinal and hepatobiliary imaging
The abdominal wall and peritoneal cavity
Part 2: Hepatobiliary system. Congenital hepatobiliary abnormalities
Acquired biliary tract disease
Parenchymal liver disease
Infectious causes of liver disease
Neoplasia
Vascular abnormalities of the liver
Liver transplantation in children
Part 3: Spleen. The spleen
Part 4: Pancreas. The pancreas
Part 5: Esophagus. Congenital and neonatal abnormalities
Disorders of swallowing
Acquired esophageal disorders
Part 6: Stomach. Congenital and neonatal abnormalities
Hypertrophic pyloric stenosis
Acquired disorders
Part 7: Duodenum and small intestine. Congenital and neonatal abnormalities
Acquired abnormalities
Acquired lesions of the small intestines
Part 8: Colon. Congenital and neonatal abnormalities
Inflammatory and infectious diseases
Intussusception
Tumors and tumorlike conditions
Abdominal trauma
Section 7: Genitourinary system. Part 1: Overview
Embryology, anatomy, and variants of the genitourinary tract
Imaging techniques
Prenatal imaging and intervention
Part 2: Prenatal imaging and intervention. Congenital and neonatal abnormalities
Acquired abnormalities (Stone disease and infection)
Renal neoplasms
Vascular conditions
Renal failure and transplantation
Part 3: Lower urinary tract. The ureter
Vesicoureteral reflux
Bladder and urethra
Part 4: Adrenal and retroperitoneum. Congenital and neonatal conditions
Acquired conditions
Part 5: Trauma. Genitourinary trauma
Part 6: Reproductive organs. Disorders of sex differentiation
Abnormalities of the male genital tract
Abnormalities of the female genital tract
Amenorrhea and abnormalities of puberty
Section 8: Musculoskeletal system. Part 1: Overview. Embryology, anatomy, and normal findings
Imaging techniques
Prenatal musculoskeletal imaging
Part 2: Congenital malformations. Congenital anomalies of bone
Skeletal dysplasias and selected chromosomal disorders
Part 3: Disorders in alignment. Alignment disorders
Scoliosis
Developmental dysplasia of the hip
Part 4: Arthritides and other inflammatory disorders. Arthritis and differential inflammatory joint disorders
Part 5: Infections. Musculoskeletal infections
Part 6: Tumors and tumor-like conditions. Soft tissue and bone tumors
Part 7: Metabolic and endocrine disorders. Metabolic bone disease
Endocrine disorders
Part 8: Systemic disease. Skeletal manifestations of systemic disease
Part 9: Trauma. Skeletal trauma
Child abuse
Sports medicine.

Summary: This collection contains hundreds of beautiful rarely-seen-before figures produced throughout the nineteenth century and the beginning of the twentieth century by famed father-of-modern-neuroscience Santiago Ramón y Cajal (1852-1934) and his contemporaries. Cajal was captivated by the beautiful shapes of the cells of the nervous system. He and his fellow scientists saw neurons as trees and glial cells as bushes. Given their high density and arrangement, neurons and glial resembled a thick forest, a seemingly impenetrable terrain of interacting cells mediating cognition and behavior.

Summary: This book is designed to focus on the role of Calcitonin Gene-Related Peptide (CGRP) in health and disease. This peptide, originally discovered in the 1980s as a sensory neuropeptide with cardiovascular effects, is now known to play a distinct role in the pain processing of migraine. The various chapters address the origin, localization and function of CGRP and its receptor in the peripheral nervous system, in the cardiovascular system, and in other tissues and organs. Further attention is paid to the drug discovery pathway where recent findings show the beneficial effect of small molecule antagonists of the CGRP receptors for the relief of the migraine attack and of monoclonal antibodies against CGRP or the CGRP receptor for migraine prevention.

Contents:
Intro; Preface; Contents; CGRP Discovery and Timeline; 1 Discovery of the Sensory Neuropeptide Calcitonin Gene-Related Peptide; 2 Family and Structure; 3 Receptors; 4 Migraine; 5 Antagonists; 6 Antibodies; 7 Other Indications for Calcitonin Gene-Related Peptide Antagonists and Antibodies; 8 Role of Calcitonin Gene-Related Peptide in the Cardiovascular System; 9 The Therapeutic Potential of Calcitonin Gene-Related Peptide Agonists; 10 Conclusion; References; CGRP Receptor Biology: Is There More Than One Receptor?; 1 Introduction; 2 Proteins with Affinity for Calcitonin Gene-Related Peptide 2 Excitatory Receptors in Primary Sensory Neurons2.1 Receptors for ATP; 2.2 PAR Receptors; 2.3 Serotonin Receptors; 2.4 Bradykinin and Prostaglandin Receptors; 3 Excitatory Channels in Trigeminal Primary Sensory Neurons; 3.1 Sodium Channels; 3.2 TRP Channels; 4 Inhibitory Receptors and Channels in Trigeminal Primary Sensory Neurons; 4.1 Adenosine Receptors; 4.2 Serotonin 5-HT1D Receptors; 4.3 Potassium Channels; 5 Agents that Provoke Migraine Attacks and Release CGRP; 5.1 Nitric Oxide Donors; 5.2 Ethanol and TRPV1; 5.3 TRPA1 Agonists 3 Pharmacology of Calcitonin Gene-Related Peptide-Responsive Receptors4 Calcitonin Gene-Related Peptide Receptors in Migraine; References; The Structure of the CGRP and Related Receptors; 1 Introduction to the CGRP Receptors; 2 The Extracellular Domain of Calcitonin Receptor-Like Receptor/Receptor Activity-Modifying Protein 1; Peptide Binding; 3 The Extracellular Domain of Calcitonin Receptor-Like Receptor/Receptor Activity-Modifying Protein 1; Non-peptide Antagonist ... ; 4 The TM Domains of Calcitonin Receptor and Calcitonin Receptor-Like Receptor; 5 The C-Terminus 5.2 Calcitonin Gene-Related Peptide Receptor Activation of Endosomal Signalling Pathways6 Calcitonin Gene-Related Peptide-Mediated Signalling in Primary Cells; 6.1 Calcitonin Gene-Related Peptide Signalling in Neuronal Cells; 6.2 Calcitonin Gene-Related Peptide Signalling in Glial Cells; 6.3 Calcitonin Gene-Related Peptide Signalling in Vascular Smooth Muscle Cells; 7 Conclusions; References; Pathways of CGRP Release from Primary Sensory Neurons; 1 Sources of CGRP Release; 1.1 Primary Sensory Neurons; 1.2 Intrinsic Gut Neurons; 1.3 Central Neurons; 1.4 Non-neuronal Cells 6 Receptor Component Protein7 Conclusion; References; CGRP Receptor Signalling Pathways; 1 The Discovery of the Calcitonin Gene-Related Peptide Receptor; 2 Calcitonin Gene-Related Peptide Receptors Mediate G Protein-Dependent Signalling; 3 Calcitonin Gene-Related Peptide Receptor Component Protein; 4 Calcitonin Gene-Related Peptide Receptor Internalization and Trafficking; 5 Calcitonin Gene-Related Peptide Receptor Signalling Pathways in Model Cell Lines; 5.1 Activation of Calcitonin Gene-Related Peptide Receptors Promotes Activation of Protein Kinases

Contents:
Voyages of discovery / Allgrove, J.
Physiology of calcium, phosphate, magnesium and vitamin D / Allgrove, J.
Physiology of bone / Grabowski, P.
Radiology of osteogenesis imperfecta, rickets and other bony fragility states / Calder, A.D.
Bone densitometry : current status and future perspective / Crabtree, N.; Ward K.
A practical approach to hypocalcaemia in children / Shaw, N.J.
Approach to the child with hypercalcaemia / Davies, J.H.
A practical approach to vitamin D deficiency and rickets / Allgrove, J.; Shaw, N.J.
A practical clinical approach to pediatric phosphate disorders / Imel, E.A. ; Carpenter, T.O.
Primary osteoporosis / Arundel, P. ; Bishop, N.
Osteoporosis in children with chronic disease / Hgler, W. ; Ward, L.
Genetics of osteoporosis in children / van Dijk, F.S.
A practical approach to children with recurrent fractures / Korula, S.; Titmuss, A.T.; Biggin A.; Munns, C.F.
Miscellaneous bone disorders / Mughal, M.Z.; Padidela, R.
Skeletal aspects of non-accidental injury / Johnson, K.; Bradshaw, K.
Skeletal dysplasias: an overview / Offiah, A.C
Drugs used in paediatric bone and calcium disorders / Cheung, M.S.
Classification of disorders of bone and calcium metabolism / Allgrove J.
Case histories / Katugampola, H. ; Saraff, V.; Kumaran, A. ; Allgrove, J.; Shaw, N.J.

Contents:
Historical overview of store-operated Ca2+ entry
The STIM1- Orai interaction
The TRPCs, Orais and STIMs in ER/PM junctions
The TRP-Na-Ca2+ exchanger coupling
Role of TRPC channels in store-operated calcium entry
Phospholipase A2 as a molecular determinant of store-operated calcium entry
Extracellular calcium has multiple targets to control cell proliferation
Regulation of platelet function by Orai, STIM and TRP
On the roles of the Transient Receptor Potential Canonical 3 (TRPC3) channel in endothelium and macrophages: implications in atherosclerosis
Second messenger-operated calcium entry through TRPC6
Transient Receptor Potential Canonical 7 (TRPC7), a Calcium (Ca2+) Permeable Nonselective Cation Channel
Calcium entry through thermosensory channels
Calcium signalling through ligand-gated ion channels such as P2X1 receptors in the platelet and other non-excitable cells
The calcium entry-calcium refilling coupling
Microdomains associated to lipid rafts
Role of scaffolding proteins in the regulation of TRPC-dependent calcium entry
Modulation of calcium entry by mitochondria
Modulation of calcium entry by the endo-lysosomal system
Remodeling of calcium entry pathways in cancer.

Contents:
Preface Calcium signaling: from basics to bedside Md. Shahidul Islam Measuring Ca2+ in living cells Joseph Bruton, Arthur J Cheng & Håkan Westerblad High-throughput fluorescence assays for Ion Channels and GPCRs Irina Vetter, David Carter, John Bassett, Jennifer R. Deuis, Bryan Tay, Sina Jami, Samuel D. Robinson. Imaging Native Calcium Currents in Brain Slices Karima Ait Ouares, Nadia Jaafari, Nicola Kuczewski and Marco Canepari Molecular diversity of plasma membrane Ca2+ transporting ATPases: their function under normal and pathological conditions. Luca Hegedűs, Boglárka Zámbó, Katalin Pászty, Rita Padányi, Karolina Varga, John T. Penniston, Ágnes Enyedi A role for SERCA pumps in the neurobiology of neuropsychiatric and neurodegenerative disorders Aikaterini Britzolaki, Joseph Saurine, Benjamin Klocke, Pothitos M. Pitychoutis Cytoplasmic Calcium Buffering: An Integrative Crosstalk Juan A. Gilabert An update on calcium binding proteins Jacobo Elíes, Matilde Yáñez, Thiago M.C. Pereira, José Gil-Longo, David A. MacDougall & Manuel Campos-Toimil Phospholipase C Colin A. Bill and Charlotte M. Vines New insights in the IP3 receptor and its regulation Jan B. PARYS & Tim VERVLIET Expression of the inositol 1,4,5-trisphosphate receptor and the ryanodine receptor Ca2+-release channels in the beta-cells and alpha- cells of the human islets of Langerhans Fabian Nordenskjöld, Björn Andersson, Md. Shahidul Islam. Evolution of Excitation-Contraction Coupling John J. Mackrill and Holly A. Shiels Molecular Insights into Calcium Dependent Regulation of Ryanodine Receptor Calcium Release Channels Naohiro Yamaguchi Sarco-endoplasmic reticulum calcium release model based on changes in the luminal calcium content visualized from the luminal side Agustín Guerrero-Hernández, Víctor Hugo Sánchez-Vázquez, Ericka Martínez-Martínez, Lizeth Sandoval-Vázquez, Norma C. Perez-Rosas, Rodrigo Lopez-Farias, Adan Dagnino-Acosta Pyridine Nucleotide Metabolites and Calcium Release from Intracellular Stores Antony Galione and Kai-Ting Chuang Calcium Signaling in the Heart Derek A. Terrar Molecular basis and regulation of store-operated calcium entry Jose J Lopez, Isaac Jardin, Letizia Albarrán, Jose Sanchez-Collado, Carlos Cantonero, Gines M Salido, Tarik Smani and Juan A. Rosado Structure and activation mechanisms of CRAC channels Carmen Butorac, Adéla Krizova, Isabella Derler Canonical Transient Potential Receptor-3 Channels in Normal and Diseased Airway Smooth Muscle Cells Yong-Xiao Wang, Lan Wang, and Yun-Min Zheng Pathophysiological significance of store-operated calcium entry in cardiovascular and skeletal muscle disorders and angiogenesis Javier Avila-Medina, Isabel Mayoral-Sanchez, Isabel Galeano-Otero, Pedro C. Redondo, Juan A. Rosado, Tarik Smani Calcium signalling and the regulation of chemosensitivity in cancer cells: role of the Transient Receptor Potential channels. Giorgio Santoni, Maria Beatrice Morelli, Oliviero Marinelli, Massimo Nabissi, Matteo Santoni, Consuelo Amantini. Targeting Transient Receptor Potential Channels by microRNAs drives tumor development and progression. Giorgio Santoni, Maria Beatrice Morelli, Matteo Santoni, Massimo Nabissi, Oliviero Marinelli and Consuelo Amantini Calcium channels and Calcium-regulated channels in human red blood cells Lars Kaestner, Anna Bogdanova, Stephane Egee Regulation of multifunctional calcium/calmodulin stimulated protein kinases by molecular targeting Kathryn Anne Skelding and John A. P. Rostas Widespread roles of CaMK-II in Developmental Pathways Sarah C. Rothschild and Robert M. Tombes Readily releasable stores of calcium in neuronal endolysosomes: Physiological and pathophysiological relevance Koffi L. Lakpa, Peter Halcrow, Xuesong Chen and Jonathan D. Geiger At the crossing of ER stress and MAMs: A key role of Sigma-1 receptor? Benjamin Delprat, Lucie Crouzier, Tsung-Ping Su, and Tangui Maurice ER-mitochondria calcium transfer, organelle contacts and neurodegenerative diseases. Francesca Vallese, Lucia Barazzuol, Lorenzo Maso, Marisa Brini and Tito Calì The Role of Mitochondrial Calcium Signaling in the Pathophysiology of Cancer Cells Andra M Sterea and Yassine El Hiani Calcium Signaling and Gene Expression Basant K. Puri Simulation Strategies for Calcium Microdomains and Calcium Noise Nicolas Wieder, Rainer H. A. Fink, Frederic von Wegner A statistical view on calcium oscillations Jake Powell, Martin Falcke, Alexander Skupin, Tomas C Bellamy, Theodore Kypraios and Rüdiger Thul Calcium Regulation of Bacterial Virulence M. King, B. Kayastha, M. J. Franklin, M.A. Patrauchan Ca2+ Signaling in Drosophila Photoreceptor Cells Olaf Voolstra and Armin Huber Calcium imaging in Drosophila melanogaster. Nicola Vajente, Rosa Norante, Paola Pizzo and Diana Pendin. Calcium imaging in the zebrafish Petronella Kettunen Stimulation-secretion coupling in the beta cells: from basic to bedside Md. Shahidul Islam Calcium dynamics and synaptic plasticity Pedro Mateos-Aparicio and Antonio Rodríguez-Moreno Calcium signaling during brain aging and its influence on the hippocampal synaptic plasticity Ashok Kumar Calcium Signaling in Endothelial Colony Forming Cells in Health and Disease Francesco Moccia Sensing Extracellular Calcium
An Insight into the Structure and Function of the Calcium-Sensing Receptor (CaSR) Sergei Chavez-Abiega, Iris Mos, Patricia P. Centeno, Taha Elajnaf, Wolfgang Schlattl, Donald T. Ward, Joachim Goedhart, Enikö Kallay Extracellular Ca2+ in bone marrow Ryota Hashimoto Calcium in Cell-Extracellular Matrix Interactions Sandeep Gopal, Hinke A. B. Multhaupt, John R. Couchman Index.

Contents:
Ryanodine and Inositol Trisphosphate Receptors/Ca2+ Release Channels in Airway Smooth Muscle Cells / Lin Mei, Yun-Min Zheng, and Yong-Xiao Wang
Kv7 (KCNQ) Potassium Channels and L-type Calcium Channels in the Regulation of Airway Diameter / Kenneth L. Byron, Lioubov I. Brueggemann, Priyanka P. Kakad, and Jennifer M. Haick
Transient Receptor Potential and Orai Channels in Airway Smooth Muscle Cells / Jun-Hua Xiao, Yong-Xiao Wang, and Yun-Min Zheng
Large-conductance calcium-activated potassium channels / Hiroaki Kume
Calcium-activated Chloride Channels / George Gallos and Charles W. Emala Sr.
Local Calcium Signaling in Airway Smooth Muscle Cells / Quing-Hua Liu, Carlo Savoia, Yong-Xiao Wang
Regulation of Airway Smooth Muscle Contraction by Ca2+ Signaling: Physiology Revealed by Microscopy Studies of Lung Slices / Michael J. Sanderson
Temporal Aspects of Ca2+ Signaling in Airway Myocytes / Etienne Roux
Mechanisms Underlying Ca2+ Store Refilling in Airway Smooth Muscle / Charlotte K. Billington, Ian P. Hall, and Carl P. Nelson
Novel Mechanisms in Ca2+-homeostasis and Internal Store Refilling of Airway Smooth Muscle / Luke J. Janssen
The Role of Mitochondria in Calcium Regulation in Airway Smooth Muscle / Philippe Delmotte, Li Jia, and Gary C. Sieck
Role of Caveolae in the Airway / Christina M. Pabelick, Brij B. Singh, and Y.S. Prakash
CD38 : Cyclic ADP-ribose-mediated Calcium Signaling in Airway Myocytes /Deepak A. Deshpande, Alonso Guedes, Mythili Dileepan, Timothy F. Walseth, and Mathur S. Kannan
The Pathways and Signaling Cross-talk with Oxidant in Calcium Influx in Airway Smooth Muscle Cells / Lei Cai and Quinghua Hu
Role of RhoA/Rho-kinase and Calcium Sensitivity in Airway Smooth Muscle Functions / Satoru Ito
Role of Integrins in the Regulation of Calcium Signaling / Thai Tran and Chun Ming Teoh
Sex Steroid Signaling in the Airway / Y.S. Prakash, Venkatachalem Sathish, and Elizabeth A. Townsend
Regulation of Contractility in Immature Airway Smooth Muscle / Y.S. Prakash, Christina M. Pabelick, and Richard J. Martin
Mathematical Modeling of Calcium Dynamics in Airway Smooth Muscle Cells / James Sneyd, Pengxing Cao, Xiahui Tan, and Michael J. Sanderson
Effects of Inflammatory Cytokines on Ca2+ Homeostasis in Airway Smooth Muscle Cells / Hisako Matsumoto
Ca2+ Signaling and P2 Receptors in Airway Smooth Muscle / Luis M. Montaño, Edgar Flores-Soto, and Carlos Barajas-López
Calcium Signaling in Airway Smooth Muscle Remodeling / Tengyao Song, Yun-min Zheng, and Yong-Xiao Wang
Regulation of Intracellular Calcium by Bitter Taste Receptors on Airway Smooth Muscle / Deepak A. Deshpande and Stephen B. Liggett
Modulation of Airway Smooth Muscle Contractile Function by TNFa and IL-13 and Airway Hyper-responsiveness in Asthma / Yassine Amrani
Airway Smooth Muscle Malfunction in COPD / Yunchao Su.

Contents:
Part 1. Reference and planning information
Part 2. Facilities inventory.

Contents:
Mechanical Alignment Total Knee Arthroplasty: A Thoughtful Beginning With Unanticipated Limitations
Phenotypes of the Knee and Limb: Rationale for Transitioning Toward Personalized Alignment in Total Knee Arthroplasty
It Is Time to Consider a Philosophical Change From Mechanical to Kinematic Alignment
Preoperative Evaluation of the Patient for Treatment With a Calipered Kinematically Aligned Total Knee Arthroplasty
Calipered Kinematic Alignment Total Knee Arthroplasty Performed With Specific Manual Instrumentation, Verification Checks, and a Decision Tree
Calipered Kinematic Alignment Using Patient-Specific Instrumentation
Calipered Kinematic Alignment With Navigation Instrumentation
Kinematic Alignment With Image-Based Robotic Instrumentation
Strategies for Improving Implant Design Based on Differences in Tibiofemoral Kinematics of a Low-Conforming Total Knee Arthroplasty Implanted With Calipered Kinematic Alignment and the Native Knee
Strategies for Improving the Prosthetic Trochlea Design Based on Differences in Trochlea Morphology Between Femoral Components Set in Kinematic and Mechanical Alignment and the Native Knee Advantages of Kinematically Aligned Total Knee Arthroplasty: A Biomechanical Perspective
Calipered Kinematically Aligned Total Knee Arthroplasty Closely Restores the Tibial Compartment Forces of the Native Knee
Clinical Outcome, Postoperative Alignment, and Implant Survivorship After Kinematically Aligned Total Knee Arthroplasty
Managing Severe Deformities With Calipered Kinematic Alignment
Kinematic Alignment Technique for Unicompartmental Knee Arthroplasty
Postoperative Management
Reducing the Risk and Methods of Managing Stiffness After Calipered Kinematically Aligned Total Knee Arthroplasty
Reducing the Risk and Management of Early and Late Tibial Component Failure After Calipered Kinematically Aligned Total Knee Arthroplasty
Reducing the Risk and Management of Patellofemoral Instability After Calipered Kinematically Aligned Total Knee Arthroplasty
Retaining the Posterior Cruciate Ligament and Restoring the Prearthritic Tibial Joint Line Reduces the Risk of Early-Onset Tibiofemoral Instability After Calipered Kinematically Aligned Total Knee Arthroplasty
Revision Total Knee Arthroplasty Using Kinematic Alignment Principles.

Contents:
Obstetric ultrasound examination
Genetics and prenatal genetic testing
Ultrasound evaluation of fetal aneuploidy in the first and second trimesters
Ultrasound of the early first trimester
Evaluation of fetal anatomy in the first trimester
Fetal biometry and growth
Ultrasound evaluation in multiple gestations
Ultrasound evaluation of normal fetal anatomy
Ultrasound evaluation of the fetal central nervous system
Ultrasound evaluation of the fetal face and neck
Fetal musculoskeletal system
Ultrasound evaluation of the fetal thorax
Sonographic evaluation of the fetal heart
Ultrasound evaluation of the fetal gastrointestinal tract and abdominal wall
Fetal genitourinary tract
Ultrasound features of fetal syndromes
Evaluation of hydrops fetalis
Ultrasound evaluation of the gravid cervix
Ultrasound evaluation of the placenta, membranes, and umbilical cord
Amniotic fluid volume in fetal health and disease
Antepartum fetal surveillance and the role of ultrasound
Role of Doppler sonography in obstetrics
Role of magnetic resonance imaging in obstetrics
Role of sonography in fetal procedures
Obstetric ultrasound imaging and the obese patient
Normal anatomy of the female pelvis and transvaginal sonography
Abnormal uterine bleeding : the role of ultrasound
Ultrasound evaluation of the uterus
Evaluation of pelvic pain in the reproductive age patient
Ultrasound evaluation of the ovaries
Ultrasound evaluation of the fallopian tube
Sonographic imaging in infertility and assisted reproduction
Ectopic pregnancy
Gynecologic sonography in the pediatric and adolescent patient
Ultrasound and magnetic resonance imaging in urogynecology
Role of magnetic resonance imaging in the evaluation of gynecologic disorders
Role of sonography in gynecologic interventions
Artifacts, pitfalls, and normal variants
Appendices. Measurements frequently used to estimate gestational age and fetal biometry
Measurements used in assessing fetal weight, growth, and body proportions
Measurements for amniotic fluid assessment
Fetal Doppler assessment (noncardiac)
Doppler of the middle cerebral artery to assess fetal anemia
Fetal cardiac measurements and Doppler assessment
Sonographic detection of chromosomal abnormalities
Medications and reported associated malformations
Estimated radiation exposure to the fetus during radiographic examinations
Magnetic resonance imaging of the female pelvis: representative protocols.

Summary: "The world is awash in bullshit, and we're drowning in it. Politicians are unconstrained by facts. Science is conducted by press release. Startup culture elevates bullshit to high art. These days, calling bullshit is a noble act. Based on Carl Bergstrom and Jevin West's popular course at the University of Washington, Calling Bullshit is a modern handbook to the art of skepticism. Bergstrom, a computational biologist, and West, an information scientist, catalogue bullshit in its many forms, explaining and offering readers the tools to see through the obfuscations, deliberate and careless, that dominate every realm of our lives. They instruct readers to ask: Who is saying it? How do they know? What do they have to gain by persuading me? Are the numbers or results too good or too dramatic to be true? Is the claim comparing like with like or apples and oranges? Is it confirming your personal bias? In this lively guide to everything from misleading statistics to "fake news," Bergstrom and West help you recognize bullshit whenever and wherever you encounter it--in data, in conversation, even within yourself--and explain it to your crystal-loving aunt or casually racist uncle. Now more than ever, calling bullshit is crucial to a properly functioning community, whether it be a circle of friends, a network of academics, or the citizenry of a nation"-- Provided by publisher.

Contents:
Bullshit everywhere
Medium, message, and misinformation
The nature of bullshit
Causality
Numbers and nonsense
Selection bias
Data visualization
Calling bullshit on Big Data
The susceptibility of science
Spotting bullshit
Refuting bullshit.

Contents:
Front Cover
Title Page
Copyright
Authors and Contributors
Dedication
Contents
Foreword Andrea Childers, RN, BSN, CPN
Acknowledgments
Introduction
Chapter 1. What Is Colic?
Chapter 2. Is It Colic or Something Else?
Chapter 3. Why Do Babies Cry?
Chapter 4. Reading Cues: What Is Your Baby Saying?
Chapter 5. Your Baby's Sensory World
Chapter 6. Your Baby's Arousal Levels
Chapter 7. Attachment and the Parent-Baby Relationship
Chapter 8. A Calming Touch: Baby Massage
Chapter 9. The Secret of Sleep --Chapter 10. Feeding Challenges and the Fussy Baby
Chapter 11. Infantile Colic: Can Diet Help?
Chapter 12. Understanding Your Baby's Postural Control
Chapter 13. The Postpartum Family
Chapter 14. Beyond Colic: Disorders in Babies Older Than 6 Months
A CALMing Last Word
Resources
Index
Back Cover.

Summary: "This book is designed primarily as a text for students beginning the study of phonetics. The exercises are intended to help the student understand and learn the information. Concept questions have been added at the end of each chapter to help students master the text information"--Provided by publisher

Summary: "The Camberwell Assessment of Need (CAN) is a standardised measure for assessing the needs of people experiencing severe and/or enduring mental health problems. It covers a wide range of health and social needs, and incorporates staff, service user and informal carer perspectives. The CAN was developed for use by three groups: a) mental health workers involved in planning care for people with severe mental health problems b) mental health service users in rating their own needs c) people wanting to evaluate mental health services. The first edition of the CAN was published in 1995 by the Section of Community Psychiatry (PRiSM) at what is now called the Institute of Psychiatry, Psychology and Neuroscience in London, England. The accompanying book was published in 1999 by Gaskell, the imprint of the Royal College of Psychiatrists"-- Provided by publisher.

Summary: "The Camberwell Assessment of Need for adults with Developmental and Intellectual Disabilities (CANDID) is a needs assessment scale specifically designed for people with intellectual disabilities (previously known as learning disabilities, mental retardation, mental handicap or mental impairment) and mental health problems. The CANDID was developed at what was then known as the Institute of Psychiatry, London (now the Institute of Psychiatry, Psychology and Neuroscience). It was developed by modification of the Camberwell Assessment of Need (CAN), an established needs assessment scale for people with severe and enduring mental illness (Slade 1999). The validity and reliability of the CAN and CANDID have been investigated by Phelan et al (1995) and Xenitidis et al (2000) respectively, and were found to be acceptable. The 1st edition of the CANDID book was published in 2003 by Gaskell, the imprint of the Royal College of Psychiatrists"-- Provided by publisher.

Contents:
Needs assessment in intellectual disabilities mental health services
Development and use of the CANDID
Using the CANDID-S
Using the CANDID-R
Training for the CANDID
Guidance on rating.

Summary: "Scientific research on the psychology of women reveals the intersectionality of women's experiences relative to those of men. There is a growing knowledge base in understanding the differences and similarities between women and men, as well as the diversities among women and sexualities. Although genetic and biological characteristics define human beings conventionally as women and men, their experiences are contextualized in multiple dimensions in terms of gender, sexuality, class, age, ethnicity and other social dimensions. Beyond the biological and genetic basis of gender differences, gender intersects with culture and other social locations which affect the socialization and development of women across their life span"-- Provided by publisher.

Summary: "This work brings together a wealth of data regarding the reference values and factors of variation in biochemical parameters used by camel veterinarians and scientists to determine these animals' nutritional and clinical status. It also explores several technical aspects involved in determining these parameters, sampling procedures, and essential elements in the interpretation of the results. Though many texts are available on small and large ruminants, much less is known about species confined to the marginal zones of tropical and Mediterranean countries, such as camels. This book addresses precisely this research gap, on the one hand by presenting an extensive review of the literature, and on the other by synthesizing the outcomes of the authors' numerous previous works. In veterinary medicine, blood tests to help diagnose diseases in cattle were first proposed nearly a century ago, but were mainly developed in the 1960s, initially at specialized research or veterinary services laboratories, and eventually, with the advent of new equipment and the miniaturization of the analyzers, finding their way into veterinarians' cabinets. Beyond their diagnostic value, veterinary surgeons and zootechnicians also speculated on the potential use of blood tests to evaluate animals' nutritional status. Thus, a whole range of analyses are now proposed to the stakeholders responsible for animal health. Such analyses could help to define a metabolic profile, which would offer a valuable decision-making tool for experts and researchers alike."-- Provided by publisher.

Contents:
Introduction
Hematology
Energetic parameters
Nitrogen and protein parameters
Clinical enzymology
Macro-minerals and electrolytes
Trace elements.

Contents:
Simultaneous assessment of cAMP signaling events in different cellular compartments using FRET-based reporters / Alex Burdyga and Konstantinos Lefkimmiatis
Recording intracellular cAMP levels with EPAC-based FRET sensors by fluorescence lifetime imaging / Marcel Raspe, Jeffrey Klarenbeek, and Kees Jalink
Novel approach combining real-time imaging and the patch-clamp technique to calibrate FRET-based reporters for cAMP in their cellular microenvironment / Andreas Koschinski and Manuela Zaccolo
Structure-based, in silico approaches for the development of novel cAMP FRET reporters / Matías Machado and Sergio Pantano
Automated image analysis of FRET signals for subcellular cAMP quantification / Silas J. Leavesley [and others]
Channel-based reporters for cAMP detection / Thomas C. Rich [and others]
Imaging sub-plasma membrane cAMP dynamics with fluorescent translocation reporters / Anders Tengholm and Olof Idevall-Hagren
Adenoviral transduction of FRET-based biosensors for cAMP in primary adult mouse cardiomyocytes / Oliver Lomas [and others]
Generation of transgenic mice expressing FRET biosensors / Daniela Hübscher and Viacheslav O. Nikolaev
Photoactivatable adenylyl cyclases (PACs) as a tool to study cAMP signaling in vivo : an overview / Marina Efetova and Martin Schwärzel
Selective disruption of the AKAP signaling complexes / Eileen J. Kennedy and John D. Scott
Screening for small molecule disruptors of AKAP-PKA interactions / Carolin Schächterle [and others]
Structure-based bacteriophage screening for AKAP- selective PKA regulatory subunit variants / Ryan Walker-Gray and Matthew G. Gold
Yeast-based high-throughput screen for modulators of phosphodiesterase activity / Ana Santos de Medeiros and Charles S. Hoffman
Separation of PKA and PKG signaling nodes by chemical proteomics / Eleonora Corradini, Albert J.R. Heck, and Arjen Scholten
Development of computational models of cAMP signaling / Susana R. Neves-Zaph and Roy S. Song.

Summary: "Focusing solely on the surgical techniques critical in helping achieve optimal patient outcomes, Campbell's Core Orthopaedic Procedures, 2nd Edition, is an ideal resource for orthopaedic and sports medicine surgeons and trainees who need a practical resource covering the top procedures in the field. This succinct, well-illustrated reference features step-by-step procedures used at the Campbell Clinic, offering practical, concise solutions you can trust for the patient scenarios you’re most likely to encounter"-- publisher's description.

Summary: "Continuing in a great tradition of publishers, editors, and authors, we proudly present to you, our readers, the twelfth edition of the "Bible of Urology"-- Campbell-Walsh-Wein Urology . Started in 1954 as Campbell's Urology and retitled Campbell-Walsh Urology in 2012, the present editors felt it was appropriate to honor Alan J. Wein, MD, PhD (Hon) for his many years of dedication to this text by adding his name to the previous chief editors. During his time as chief editor, Dr. Wein was responsible for keeping the textbook in pace with a rapidly growing field in medicine--for this diligence and dedication we are grateful. As with previous editions, the twelfth edition presents many exciting advances in our use and understanding of technology, physiology, pharmacology, epidemiology, and pathophysiology while maintaining our basic classical urological knowledge"--Preface.

Contents:
History of surgery for limb bone tumors
Non-Surgical Treatment Of Pediatric Bone Sarcomas
Molecular Biology of Pediatric Bone Sarcomas
Limb Salvage in Skeletally Immature Patients with Extremity Sarcoma
Location of Sarcomas Within Bone: The Growth Plate
A Histological Study of the Barrier Effect of the Physis Against Metaphyseal Osteosarcoma
Growth Plate Involvement in Malignant Bone Tumours: Relationship Between Imaging Methods and Histological Findings
Consequences of Delayed Diagnosis
Imaging-Based Indications for Resection with Epiphyseal Preservation
Conservation of the Epiphysis While Removing Metaphyseal Bone Tumors: Epiphysiolysis Before Excision
Complications of the technique and solutions
Clinical Results
Other Techniques for Epiphyseal Preservation
Worldwide Experience with the Cañadell Technique
Questions and Answers.

Contents:

v. 1. Etiology : chemical and physical carcinogenesis.

Summary: This comprehensive, ground-breaking title presents, in simplifying style, the driving and organizing principles of cancer, making this multidimensional, highly complex disease easily understandable for readers. Developed out of the renowned author's many years of teaching a widely popular, several-hundred-student college course, this 12-chapter book begins with an account of the history of cancer as a medical and public health problem, as well as the major milestones and setbacks in the ongoing quest to understand the wide variety of cancers that continue to impact the world. Subsequent chapters then address pathogenesis, incidence and mortality statistics, risk factors, causal factors, screening challenges and victories, treatment strategies, and disease prevention approaches. This wealth of clinical information is further supplemented with socioeconomic discussions on the financial, social, ethical, technological, regulatory, political, and logistical challenges that limit progress in cancer research. A soon to be gold-standard text that thoroughly and expertly describes cancer as a composite, adaptive system, Cancer: The Enemy from Within equips and empowers all undergraduate students and graduate students to better understand this continually perplexing disease. Clinicians across all disciplines may also find this work of great interest.

Contents:
Chapter 1. The Nature and Origins of Cancer
Chapter 2. Cancer Initiation, Promotion and Progression and the Acquisition of Key Behavioral Traits
Chapter 3. Understanding the Hallmark Characteristics of Cancer
Chapter 4. A Short History of Cancer
How Did We Get Here?
Chapter 5. Who Gets Cancer and Why? What Are the Consequences for Human Life and .-Longevity? How Can We Intervene? How Can We Track Progress?
Chapter 6. Screening for Cancer: Find It Early; Treat It Early; Save Lives
Chapter 7. Fundamentals of Cancer Diagnosis and Assessment
Chapter 8. Local Therapy for Cancer
Chapter 9. Systemic Therapy for Cancer
Chapter 10. Palliative Care, Hospice, and End of Life
Chapter 11. Development of New Cancer Therapies
Chapter 12. Cancer and Society.

Contents:
1. Introduction
2. Awareness and paying attention
3. The value of paying attention
4. Relevant aspects of sexuality
5. The various levels of impact
6. A comprehensive guideline on sexual care in case of cancer
7. Training in oncosexology
8. Sexual consequences of the various process phases
9. Psychosexual consequences of cancer diagnosis
10. Sexual consequences of pelvic radiotherapy
11. Sexual consequences of chemotherapy
12. The sexual consequences of cancer surgery
13. Sexual consequences of cancer medication and cancer-related medication
14. Sexual aspects of specific cancers
15. Breast cancer and sexuality
16. Sexual function after gynaecological cancer
17. Prostate cancer
18. Sexual problems related to bladder cancer
19. Sexual consequences to testicular cancer
20. Penile cancer and sexuality
21 Colorectal and anal cancer
22. Blood and lymph node cancer
23. Sexual consequences of head and neck cancer
24. "Dealing with"
25. Couple sexual rehabilitation
26. Male sexual rehabilitation after pelvic cancer
27. Sexual rehabilitation after gyneacological cancers
28. Sexual tools and toys in oncosexology
29. Special groups
30. The partner
31. The impact of cancer treatment on sexuality and relationships for the teenage and young adult cancer survivors
32. Sexuality and cancer in the aged/aging population
33. Homosexual men and women, cancer, and the health care system
34. Sexuality and intimacy at the end of life.

Summary: The atlas provides a clear, concise, yet comprehensive review of common cardiovascular diseases occurring in patients with cancer. Cancer and cardiovascular disease are the two most common conditions worldwide. In clinical practice we frequently encounter patients who have established cardiovascular disease and subsequently develop cancer or are survivors of cancer with subsequent cardiovascular complications related to chemotherapy and or radiation. Most of the chapters are case based, followed by images and a discussion on current (evidence based, wherever available) investigations and treatment outline.

Contents:
Chemotherapy induced Cardiomyopathy
Hypertension associated with chemotherapeutic agents
Pericardial disease
Radiation and Heart
Management of Coronary Artery disease in patients with Cancer
Management of Valvular heart disease in patients with Cancer
Peripheral arterial disease in patients with Cancer
Cardiac tumors
Common Cardiac arrhythmias in patients with cancer.

Contents:
1. What is comorbidity?
2. How do we measure comorbidity?
3. Cancer, chronic conditions and social disadvantage--the perfect storm
4. Impact of comorbidity on cancer screening and diagnosis
5. Impact of comorbidity on treatment decision making and outcomes
6. The impact of cancer and chronic conditions on caregivers and family members
7. Prevention of chronic conditions and cancer
8. Chronic condition management models for cancer care and survivorship
9. The mamangement of polypharmacy in people with cancer and chronic conditions
10. Breaking the silos: integrated care for cancer and chronic conditions
11. Advocacy in cancer and chronic conditions--challenges and opportunities
12. Research considerations in patients with cancer and comorbidity
13. The cost of cure: chronic conditions in survivors of child, adolescent, and young adult cancers
14. Chronic conditions and cancer in older adults
15. Chronic conditions and cancer at the end of life.

Contents:
1. Demographics of cancer in the reproductive age male
2. Demographics of cancer in the reproductive age female
3. Physiology of spermatogenesis: opportunities for disruption
4. Fertility assessment in the male
5. Fertility assessment in the female
6. Fertility conditions associated with cancer development
7. Chemotherapy and fertility
8. Radiation therapy and fertility
9. Sperm banking for cancer patients --10.Fertility preservation strategies in the male cancer patient
11. Fertility preservation in the female cancer patient
12. Cancer treatment in pregnancy
13. Surgical approaches for sperm harvest in the azoospermic cancer patient
14. Stem cells and fertility
15. The role of assisted reproduction in the cancer patient
16. Third party reproduction
Index.

Contents:
Infection, inflammation, and cancer: overview / Hiroshi Ohshima, Noriyuki Miyoshi, and Susumu Tomono
Stem cell theory and inflammation-related cancer / Toshihiko Tanno and William Matsui
Epithelial-mesenchymal transition: a link between cancer and inflammation / Jonas Fuxe and Mikael C.I. Karlsson
Role of nitrative DNA damage in inflammation-related carcinogenesis / Yusuke Hiraku and Shosuke Kawanishi
Lipid peroxidation-derived DNA adducts and the role in inflammation-related carcinogenesis / Helmut Bartsch and Urmila Jagadeesan Nair
Level of inflammation-related DNA adducts in human tissues / Tomonari Matsuda, Pei-Hsin Chou, and Haruhiko Sugimura
Toll-like receptors: role in inflammation and cancer / Sarang Tartey and Osamu Takeuchi
Inflammasomes and inflammation / Kaiwen W. Chen, Ayanthi A. Richards, Alina Zamoshnikova, and Kate Schroder
Activation-induced cytidine deaminase: an intrinsic genome modulator in inflammation-associated cancer development / Hiroyuki Marusawa and Tsutomu Chiba
MicroRNA and inflammation-related cancer / Zhaojian Gong, Zhaoyang Zeng, Pranab Behari Mazumder, Jian Ma, Ming Zhou, Xiayu Li, Xiaoling Li, Wei Xiong, Yong Li, and Guiyuan Li
Inflammation as a niche for tumor progression / Futoshi Okada
Human papillomavirus and cervical cancer / Kurt J. Sales
Hepatitis viruses and hepatocellular carcinoma / Wai-Kay Seto, Ching-Lung Lai, and Man-Fung Yuen
Epstein-Barr virus and nasopharyngeal carcinoma / Xiaoying Zhou, Xue Xiao, Fu Chen, Tingting Huang, and Zhe Zhang
Barrett's esophagus and esophageal cancer / Albert Roessner and Angela Poehlmann
Asbestos-induced chronic inflammation and cancer / Andrea Napolitano, Sandro Jube, Giovanni Gaudino, Harvey I. Pass, Michele Carbone, and Haining Yang
Nanomaterials / Yiqun Mo, Rong Wan, David J. Tollerud, and Qunwei Zhang
Inflammatory pathways of radiation-induced tissue injury / Danae A. Laskaratouu, Ifigeneia V. Mavragani, and Alexandros G. Georgakilas
Photocarcinogenesis and inflammation / Chikako Nishigori
Chemoprevention of colorectal cancer by anti-inflammatory agents / Michihiro Mutoh, Mami Takahasi, and Keiji Wakabayashi
Nutraceuticals and colon cancer prevention / Deepak Poudyal and Lorne J. Hofseth
Cancer chemoprevention by targeting cox-2 using dietary phytochemicals / Kyung-Soo Chun and Young-Joon Surh
Regulation of inflammation-associated intestinal diseases with phytochemicals / Akira Murakami.

Summary: While a number of books have looked at the intersection between human health in general and other topics, such as climate change or diet, this book focuses specifically on cancer as it impacts and is impacted by social justice issues. The massive explosion of research knowledge of cancer immunology and genomics is holding out great promise of therapeutic advances, yet other human actions—climate change, pollution, business decisions, advertising – are fostering health inequalities as well as increasing risks. Those involved in cancer care and research are in a unique position to let their experiences and knowledge inform the public, yet very often have not taken strong public roles when it comes to discussing issues surrounding tobacco, climate change and health risks, financial toxicity of treatments, and diet choices. Written by a multidisciplinary team of authors and for medical oncologists, cancer researchers, occupational health workers, and related medical students, residents, and fellows, this book encourages oncologists to address public health care and the societal issues associated with cancer risk. This volume discusses the overarching theme of environmental justice and oncology, focuses on business and cancer (such as clinical trials, drug development and profits, and global disparities), as well as animals and cancer. .

Contents:
Part 1. Powers of the zebrafish model. Uncharted waters: zebrafish cancer models navigate a course for oncogene discovery / Craig J. Ceol and Yariv Houvras
The toolbox for conditional zebrafish cancer models / Marie Mayrhofer and Marina Mione
Approaches to inactivate genes in zebrafish / John M. Parant and Jing-Ruey Joanna Yeh
Tumor suppressors in zebrafish: from TP53 to PTEN and beyond / Jeroen den Hertog
Identifying novel cancer therapies using chemical genetics and zebrafish / Michelle Dang, Rachel Fogley, and Leonard I. Zon
Genomic approaches to zebrafish cancer / Richard M. White
Transcriptomic analyses in zebrafish cancer models for global gene expression and pathway discovery / Xiaoqian Huang, Ira Agrawal, Zhen Li, Weiling Zheng, Qingsong Lin, and Zhiyuan Gong
zebrafish discoveries in cancer epigenetics / Yelena Chernyavskaya, Brandon Kent, and Kirsten C. Sadler
Lymphatics, cancer and zebrafish / Jonathan W. Astin and Philip S. Crosier
In vivo imaging of cancer in zebrafish / Myron S. Ignatius, Madeline Hayes, and David M. Langenau
Imaging cancer angiogenesis and metastasis in a zebrafish embryo model / C. Tulotta, S. He, W. van der Ent, L. Chen, A. Groenewoud, H. P. Spaink, and B. E. Snaar-Jagalska
Allograft cancer cell transplantation in zebrafish / John C. Moore and David M. Langenau
The zebrafish xenograft platform: evolution of a novel cancer model and preclinical screening tool / Jaime Wertman, Chansey J. Veinotte, Graham Dellaire, and Jason N. Berman
Automation of technology for cancer research / Wietske van der Ent, Wouter J. Veneman, Arwin Groenewoud, Lanpeng Chen, Claudia Tulotta, Pancras C.W. Hogendoorn, Herman. P. Spaink, and B. Ewa Snaar-Jagalska
part 2. Cancer models in fish. zebrafish models of human leukemia: technological advances and mechanistic insights / Nicholas R. Harrison, Fabrice J.F. Laroche, Alejandro Gutierrez, and Hui Feng
Zebrafish Rhabdomyosarcoma / Michael Phelps and Eleanor Chen
Baiting for cancer: using the zebrafish as a model in liver and pancreatic cancer / Katie L. Hwang and Wolfram Goessling
Focusing the spotlight on the zebrafish intestine to illuminate mechanisms of colorectal cancer / Viola H. Lobert, Dmitri Mouradov, and Joan K. Heath
zebrafish Melanoma / Charles K. Kaufman
Neuroblastoma and its zebrafish model / Shizhen Zhu and A. Thomas Look
zebrafish germ cell tumors / Angelica Sanchez and James F. Amatruda
Malignant peripheral nerve sheath tumors / Adam D. Durbin, Dong Hyuk Ki, Shuning He, and A. Thomas Look
Xiphophorus and medaka cancer models / Manfred Schartl and Ronald B. Walter.

Summary: This new series, based on a bi-annual conference and its topics, represents a major contribution to the emerging science of cancer research and regenerative medicine. Each volume brings together some of the most pre-eminent scientists working on cancer biology, cancer treatment, cancer diagnosis, cancer prevention and regenerative medicine to share information on currently ongoing work which will help shape future therapies. These volumes are invaluable resources not only for already active researchers or clinicians but also for those entering these fields, plus those in industry. Cancer Biology and Advances in Treatment is a proceedings volume which reflects papers presented at the 3rd bi-annual Innovations in Regenerative Medicine and Cancer Research conference; taken with its companion volume Tissue Engineering and Regenerative Medicine and Stem Cells: Biology and Engineering it provides a complete overview of the papers from that meeting of international experts.

Contents:
1. The BRCA1 and BRCA2 genes in early onset breast cancer patients
2. Anti-cancer effect of Xao tam phan Paramignya trimera methanol root extract on human breast cancer cell line MCF-7 in 3D model
3. A novel nonsense mutation c.374C>G in CYP21A2 gene of a Vietnamese patient with congenital adrenal hyperplasia
4. Variation of Mitochondrial DNA HV1 AND HV2 of the Vietnamese Population
5. Synthesis and Characterization of PLGA-PEG Thymoquinone Nanoparticles and its Cytotoxicity Effects in Tamoxifen-resistant Breast Cancer Cells
6. Adipose-derived mesenchymal stem cells promote growth and migration of lung adenocarcinoma cancer cells
7. Predictive potential of PD-L1, TYMS and DCC expressions in treatment outcome of colorectal carcinoma
8. Clinical trials with cytokine-induced killer cells and CAR-T cell transplantation for non-small cell lung cancer treatment
9. Isopanduratin A isolated from Boesenbergia pandurata reduces HepG2 hepatocellular carcinoma cell proliferation in both monolayer and three-dimensional cultures
10. Hopea Odorata extract can efficiently kill breast cancer cells and cancer stem like cells in three-dimensional culture more than in monolayer cell culture
11. Selective cytotoxicity of some plant extracts against hepatocellular carcinoma cells but not mesenchymal stem cells: A pilot screening.

Summary: Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology, but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis, and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers, and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer.

Contents:
Part I. History and use of the nuclear envelope in cancer prognosis
Part II. The nuclear envelope in cell cycle regulation and signaling
Part III. Nuclear envelope regulation of the genome
Part IV. Functions of the NPC in cancer
Part V. The nuclear envelope in DNA damage and stress responses
Part VI. Towards a molecular explanation of prognostic links to the nuclear envelope
Erratum to
Index.

Summary: The ability to measure and monitor cancer biomarkers in "body fluid biopsy" should greatly impact oncologic practice. "Biomarkers in Proximal Fluids", the third of the "Cancer Biomarkers in Body Fluids" series details cancer signatures in none or minimally circulating body fluids including saliva, sputum, bronchoalveolar lavage fluid, exhaled breath condensate, nipple aspirate fluid, gastric and pancreatic juice, stool, urine, and prostatic, peritoneal and cerebrospinal fluid. These fluids are enriched with biomarkers, especially those emanating from cells of the proximal tissue. Chapter 1 examines the global burden of cancer and the need for regional efforts at primary prevention, early detection and patient care. Chapters 2-12 address tissue-specific biomarkers in associated body fluids. The tumor interstitial fluid as a microenvironment rich in cancer biomarkers is detailed in chapter 13, while chapter 14 looks at the human body fluid microbiome and its evolving role in cancer. Commercially available assays using proximal fluids are examined at the end of the respective chapters. This book complements its predecessors and is equally useful to oncologists, cancer researchers, clinicians, medical students, nurses, diagnostic laboratory and pharmaceutical industry personnel.

Contents:
1. Melanoma Biomarkers in Exfoliated Cells
2. Head and Neck Cancer Biomarkers in Saliva
3. Lung Cancer Biomarkers in Lung Fluids
4. Breast Cancer Biomarkers in Breast Fluids
5. Gastric Cancer Biomarkers in Gastric Fluid
6. Colorectal Cancer Biomarkers in Stool
7. Hepatobiliary Cancer Biomarkers in Bile
8. Pancreatic Cancer Biomarkers in Pancreatic Juice
9. Renal Cancer Biomarkers in Urine
10. Bladder Cancer Biomarkers in Urine
11. Prostate Cancer Biomarkers in Prostatic Fluid
12. Testicular Cancer Biomarkers in Seminal Fluid
13. Ovarian Cancer Biomarkers in Peritoneal Fluid
14. Endometrial Cancer Biomarkers in Menstrual Fluid
15. Cervical and Vulvar Cancer Biomarkers in Exfoliated Cells
16. Brain Cancer Biomarkers in Cerebrospinal Fluid
17. Hematologic Cancer Biomarkers in Blood
18. The Body Fluid Microbiome and Cancer
19. Biomarkers in Interstitial Fluids of Cancer Cells.

Contents:
Medical Care in Countries in Transition
How to Prioritize Cancer Care for Countries in Transition
Cancer Trends and Risk Factors in Morocco
The Magic of Dreams: Conflicts and Quandaries Within Multicultural Societies in Transition
Modeling Integrative Oncology for the Arab Population in Northern Israel
Cancer Care in Palestine
Influx of Foreign Refugees to Jordan and its Overall Burden on Cancer Care
Caring For Children With Cancer In A Country Conflicted With Massive Refugee Migration: Jordan as an Example
Challenges and Future Trends for Cancer Care in Egypt
Cancer Care in Lebanon, New Trends and Challenges
Cancer Care in an economically torn country: Cyprus
Cancer Care in a Country Undergoing Transition: Turkey. Current Challenges and Trends for the Future
Cancer Care in Sudan: Current Situation and Challenges
Cancer care in Countries in Transition in Africa; the case of Uganda
Cancer Care in Pakistan
Cancer Care in India
Cancer Care in Afghanistan
Kazakhstan
An overview of cancer care in societies in transition- Global perspectives: UAE Experience
Cancer care in countries in transition: The Islamic Republic of Iran
Cancer Care in Regions/Societies in Transition in the Gulf States: Sultanate of Oman
Challenges and prospects in cancer care in Georgia
Romania: Attempting to Catch up the European standards of care for cancer patients
Recent challenges and achievements in cancer care in Latin American societies
Caring for Refugees with Cancer: A Case for Training of US Oncology Professionals
University of Texas MD Anderson Cancer Center Experience caring for patients from countries undergoing political-social conflict
Forty Years Fast Forward: Vietnamese Refugees in the United States with Comments on their Cancer Care
The current state of cancer care in North America
Application of genetic testing for childhood cancers in emerging countries
Cancer Care among Immigrants to North America
Promoting Cancer Nursing Education, Training and Research in Countries in Transition.

Summary: This book illustrates various aspects of cancer cell metabolism, including metabolic regulation in solid tumours vs. non-solid tumours, the molecular pathways involved in its metabolism, and the role of the tumour microenvironment in the regulation of cancer cell metabolism. It summarizes the complexity of cancer cell metabolism in terms of the switch from anaerobic to aerobic glycolysis and how mitochondrial damage promotes aerobic glycolysis in cancer cells. The respective chapters provide the latest information on the metabolic remodelling of cancer cells and elucidate the important role of the signalling pathways in reprogramming of cancer cell metabolism. In addition, the book highlights the role of autophagy in cancer cell metabolism, and how metabolic crosstalk between cancer cells and cancer-associated fibroblasts promotes cancer cell progression. In closing, it summarizes recent advancements in drug development through targeting cancer metabolism.

Contents:
Chapter 1: Cancer cell metabolism: Solid tumor vs non-solid tumor
Chapter 2: Reprogramming of cancer cell metabolism: Warburg and Reverse Warburg hypothesis
Chapter 3: Molecular aspects of cancer cell metabolism: Altered glycolysis and lipid metabolism
Chapter 4: Understanding the metabolic cross-talk between cancer cells and cancer-associated fibroblasts
Chapter 5: Metabolic cross-talk between cancer cells and tumor microenvironment
Chapter 6: Role of autophagy in cancer cell metabolism
Chapter 7: Role of c-Met/HGF axis in altered cancer metabolism
Chapter 8: Recent advances in drug development targeting cancer metabolism
Chapter 9: Clinical relevance of "Diagnostic markers" in cancer metabolism
Chapter 10: Alterations in Metabolite-driven Gene Regulation in Cancer Metabolism
Chapter 11: Role of Phytochemicals in Cancer Cell Metabolism Regulation.

Contents:
Use of Biguanides to Improve Response to Chemotherapy
Evaluating Response to Metformin/Cisplatin Combination in Cancer Cells Via Metabolic Measurement and Clonogenic Survival
Quantifying the Autophagy-Triggering Effects of Drugs in Cell Spheroids with Live Fluorescence Microscopy
Interdependency Between Genetic and Epigenetic Regulatory Defects in Cancer
Experimental Strategies to Manipulate the Cellular Levels of the Multifunctional Factor CTCF
Use of Serum-Circulating miRNA Profiling for the Identification of Breast Cancer Biomarkers
Prostate Cancer Detection Using a Non-Invasive Method for Quantifying mi RNAs
DNA Methylation Analysis of Steroid Hormone Receptor Genes
Control of Oncogenic mi RNA Function by Light-Activated mi RNA Antagomirs
Methods for the Study of Long Non-Coding RNA in Cancer Cell Signaling
Microvesicles as Mediators of Intercellular Communication in Cancer
In Vivo Rat Model to Study Horizontal Tumor Progression
An In Vivo Model to Study the Effects of Tumoral Soluble Factors on the Vascular Permeability in Mice
Use of the Tumor Repressor DEDD as a Prognostic Marker of Cancer Metastasis
Zebrafish-Based Systems Pharmacology of Cancer Metastasis
A Flow Cytometry-Based Assay for the Evaluation of Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) in Cancer Cells
Gene Disruption Using Zinc Finger Nuclease Technology.

Contents:
Section 1 Malignant hematology and hematopoietic cell transplantation
Part 1 Acute lymphoblastic leukemia in adults
Part 2 Acute myeloid leukemia in adults
Part 3 Myelodysplastic syndromes and related disorders
Part 4 Myeloproliferative neoplasms
Part 5 Chronic lymphocytic and other leukemias
Part 6 Hodgkin Lymphoma
Part 7 Non-Hodgkin's lymphomas
Part 8 Plasma cell neoplasms and related disorders
Part 9 Special issues in hematology
Part 10 Special issues in hematopoietic cell transplantation
Section 2 Oncology
Part 1 Central nervous system tumors
Part 2 Head and neck cancers and thoracic malignancies
Part 3 Breast cancer
Part 4 Gastrointestinal oncology
Part 5 Genitourinary oncology
Part 6 Skin malignancies
Part 7 Gynecological malignancies
Part 8 Sarcomas
Part 9 Multidisciplinary approach: consultation with surgical oncology team
Part 10 Multidisciplinary approach: consultation with radiation oncology team
Part 11 Hereditary cancer syndromes and genetic testing in oncology
Part 12 Special issues in hematology and oncology.

Summary: This book proposes the importance of new systems of drug design and delivery based on cancer pathophysiology in addition to cancer molecular and cellular biology. The current studies based on molecular and cellular biology while ignoring pathophysiology and pharmacology may be leading the development of antitumor drugs in the wrong direction and wasting a lot of money. Although there have been numerous reports of genetic and phenotypic changes in tumors, a large body of pathological and clinical evidence supports the conclusion that there are no pivotal changes in tumor cells that distinguish them consistently and reliably from normal dividing cells. Unlike using antibiotics against bacterial infection, therefore, anticancer agents (ACAs) need to be delivered selectively to tumor tissues and should be kept there long enough to reproduce the concentrations they reach in the Petri dish, which is a closed space where the cytocidal effects of any anticancer agents (ACAs) including molecular targeting agents are very strong. In the body, however, administered ACAs are cleared with the passage of time. Furthermore, most human cancers possess abundant stroma that hinders the penetration of drugs into the tumor microenvironment. Therefore, to overcome these difficulties, novel drug delivery systems have been designed, such as nanoparticles and ACA conjugated antibodies to stromal components and to cancer cell surface antigens. These advances are described in this book after the first section, which describes core features of the pathophysiology of the cancer microenvironment, on which these new developments are based.

Contents:
Preface
Part I Cancer pathophysiology
1. The Cancer Stroma and its relevance to tumor survival
2. Cancer and blood coagulation
3. Tumor Blood Vessels as targets for cancer therapy
4. Stromal barriers within the tumor microenvironment and obstacles to nanomedicine
Part II Antibody drug conjugates (ADC)
1. Recent progress in linker technology for antibody-drug conjugates: Methods for connection and release
2. Preclinical studies of ADC therapy for solid tumors
3. ADCs on the market and in clinical development
Part III Hybrid techniques of active and passive targeting
1. Micelles conjugated with a pilot molecule
2. Liposomes conjugated with a pilot molecule
3. Multifunctional Envelope-type Nano Devices (MEND) for cancer therapy
Part IV Cancer stromal targeting (CAST) therapy and diagnosis
1. Principle of CAST
2. CAST therapy
3. CAST diagnosis
Part V The Current Status of Cancer Drug Delivery Systems and Future Directions
Index.

Summary: This book offers a wide-ranging description and analysis of recent developments and current trends in health policy with regard to cancer drug safety. The book opens with an overview of pharmacovigilance for cancer blockbuster drugs, covering both general considerations and efforts to develop a structured framework for the identification and reporting of adverse drug reactions (ADRs). A number of important examples of serious ADRs to hematology and oncology drugs are then reviewed, with evaluation of the lessons learned and the policy implications of the ensuing legal cases and their settlements. Further, the difficulty of reporting such blockbuster side effects in the medical literature is explored in an empirical study. Significant advances have been achieved in analytic methods for the identification of ADRs, and here there is a particular focus on the value of optimal discriminant analysis. Finally, the impacts on pharmacovigilance and drug safety of the huge fines paid under the U.S. False Claims Act relating to the defrauding of governmental programs also receive careful attention these fines are playing an important role in changing the landscape for pharmaceutical safety.

Contents:
Intro
Preface
Contents
Editors and Contributors
1 Fluoroquinolone-Associated Disability and Other Fluoroquinolone-Associated Serious Adverse Events: Unexpected Toxicities Have Emerged in Recent Years
1.1 Introduction
1.1.1 FQ Adverse Event Drug Label Warnings
1.1.2 FQ Drug Label Changes (See Table 1.1 for Levofloxacin Label Changes)
1.1.3 FDA Reports of FQ Adverse Events
1.1.4 November 5, 2015, FDA Advisory Committee Meeting Identifies FQAD
1.1.5 November 5, 2015, FDA Advisory Committee Votes
1.1.6 Boxwell FDA FQ Data Compared with Social Media FQ Reports 1.1.7 Gender
1.1.8 Specific FQs
1.1.9 Duration of FQAD
1.1.10 FQAD: Reasons for Which FQ was Prescribed
1.1.11 FQAD Specific Events
1.1.12 Possible Mechanism of FQ Toxicities
1.1.13 Another Possible Pathophysiologic Mechanism: Matrix Metalloproteinase Toxicity
1.1.14 FQ-Associated Peripheral Neuropathy
1.1.15 Levaquin Clinical Trials Completed Prior to FDA Approval in 1997
1.1.16 2001 FDA FQ Review
1.1.17 2003 FDA FQ Review
1.1.18 2008 FDA Pediatric Levofloxacin Review
1.1.19 2010 Pfizer Report
1.1.20 2011 Levaquin Postmarketing Review 1.1.21 2013 FDA Review
1.1.22 2014-Present Media Reports Regarding FQs
1.1.23 2014 FDA Advisory Committee Comments
1.1.24 2014 FDA Dear Healthcare Professional Letters
1.1.25 2014 Citizen Petition
1.1.26 2014 Meeting with U.S. Senate Health Committee
1.1.27 2015 Meeting with FDA
1.1.28 2015 FQ Case Studies
1.1.29 2015 FDA Advisory Committee Meeting
1.1.30 2015 FDA Listening Session
1.1.31 2016 FQ Neuropsychiatric Study
1.1.32 2016 FQ Label Updates
1.1.33 2016 FDA Response to Citizen Petition
1.1.34 2018 FQ Nature Article
1.1.35 2019 Citizen Petition 1.1.36 2019 FQ Neuropsychiatric Toxicity Study
1.2 Discussion
1.3 Conclusions
1.3.1 Recommendations
1.3.2 Significance of This FQ Study
1.4 REMS Request
References
2 Biosimilar Epoetin in the United States: A View from the Southern Network on Adverse Reactions
2.1 Introduction
2.1.1 Regulatory Approval for Epoetin Biosimilar in the United States
2.1.2 Chemistry, Manufacturing, and Controls
2.1.3 Biological Activity
2.1.4 Pharmacology/Toxicology
2.1.5 Immunogenicity
2.1.6 Clinical Pharmacology
2.1.7 Clinical Efficacy and Safety 2.1.8 Risk Evaluation and Mitigations Strategy (REMS)
2.1.9 Extrapolation
2.1.10 Findings of the Oncology Drug Advisory Committee (ODAC) of the FDA
2.1.11 Patents and Litigation
2.1.12 Naming and Labeling
2.1.13 Interchangeability
2.1.14 Substitution
2.1.15 Pharmacovigilance and Immunogenicity
2.1.16 Lessons from the European Union (EU) Countries
2.1.17 Lessons from Japan
2.2 Conclusions
References
3 Policing of Drug Safety Information Dissemination Under the False Claims Act
3.1 Introduction
3.1.1 The Settlement
Radiotherapy

Contents:
Cancer epigenetics : an introduction / Rajnee Kanwal, Karishma Gupta, and Sanjay Gupta
Community resources and technologies developed through the NIH roadmap epigenomics program / John S. Satterlee ... [et al.]
Epigenome-wide association studies (EWAS) : past, present, and future / James M. Flanagan
Epigenetic biomarkers in liver cancer / Krishna K. Banaudha and Mukesh Verma
Cancer type-specific epigenetic changes : gastric cancer / Danielle Queiroz Calcagno, Marília de Arruda Cardoso Smith, and Rommel Rodriguez Burbano
Beyond the island : epigenetic biomarkers of colorectal and prostate cancer / Andrea J. Savio and Bharati Bapat
Prostate cancer epigenome / Swathi Chinaranagari ... [et al.]
CpG island hypermethylation as a biomarker for the early detection of lung cancer / Yujin Kim and Duk-Hwan Kim
Analysis of DNA methylation in pancreatic cancer : an update / Christian Pilarsky and Robert Grützmann
Epigenetics of urothelial carcinoma / Wolfgang A. Schulz ... [et al.]
Epigenetics of prostate cancer / Tawnya C. McKee and James V. Tricoli
Methylation profile landscape in mesothelioma : possible implications in early detection, disease progression, and therapeutic options / Xinbo Zhang ... [et al.]
Techniques to access histone modifications and variants in cancer / Monica Tyagi ... [et al]
Single base resolution analysis of 5-methylcytosine and 5-hydroxymethylcytosine by RRBS and TAB-RRBS / Maria A. Hahn ... [et al.]
Quantitative DNA methylation analysis for epigenotyping of colorectal cancer / Atsushi Kaneda and Koichi Yagi
Histone modifications associated with cancer cell migration and invasion / Miki Hieda, Nariaki Matsuura , and Hiroshi Kimura
Aberrant epigenetic modifications in radiation-resistant head and neck cancers / Hon-Yi Lin, Tim Hui-Ming Huang, and Michael Wing-Yan Chan
Cancer-associated infectious agents and epigenetic regulation / Vidya Vedham and Mukesh Verma
Toxicoepigenomics and cancer : implications for screening / Mukesh Verma
Human papilloma virus (HPV) modulation of the HNSCC epigenome / Josena K. Stephen and Maria J. Worsham
Epigenetic regulation of HIV, AIDS, and AIDS-related malignancies / Mukesh Verma
Epigenetics of colorectal cancer / Wenji Yan and Mingzhou Guo
Epigenetics in breast and prostate cancer / Yanyuan Wu, Marianna Sarkissyan, and Jaydutt V. Vadgama
Epigenetic inhibitors / Mukesh Verma and Hirendra Nath Banerjee
Use of epigenetic modulators as a powerful adjuvant for breast cancer therapies / Aurore Claude-Taupin ... [et al.]
Epigenetic approaches in glioblastoma multiforme and their implication in screening and diagnosis / Gwyneth Hyman ... [et al.]
Detection of circulatory microRNAs in prostate cancer/ Anvesha Srivastava ... [et al.]
Identification and characterization of small-molecule inhibitors of lysine acetyltransferases / Daiqing Liao
Epigenetic regulation in biopsychosocial pathways / Kristin Litzelman and Mukesh Verma
Viral epigenetics / Barry I. Milavetz and Lata Balakrishnan
P53 tumor suppression network in cancer epigenetics / Alok Mishra, Daniel J. Brat, and Mukesh Verma
Promoter hypermethylation as a biomarker in prostate adenocarcinoma / Jong Y. Park
Sequencing the cancer methylome / Austin Y. Shull ... [et al.]
Global DNA methylation profiling technologies and the ovarian cancer methylome / Jessica Tang ... [et al.]
Recent progress in the discovery of epigenetic inhibitors for the treatment of cancer / Sharad K. Verma
At the crossroad between obesity and gastric cancer / Jone Garai ... [et al.]
Detection of epigenetic aberrations in the development of hepatocellular carcinoma / Yujing Zhang
Specific type epigenetic changes in cervical cancers / Shuping Zhao
Epigenetics in head and neck cancer / Syeda Marriam Bakhtiar, Amjad Ali, and Debmalya Barh
Epigenetic therapy for colorectal cancer / Vivek Vaish ... [et al.]
Epigenetics of gastric cancer / Mingzhou Guo and Wenji Yan.

Summary: "A guide and comprehensive reference for the care of patients with hereditary cancer syndromes. This book is intended to provide the essential tools needed to understand clinical cancer genetics"-- Provided by publisher.

Contents:
Critical Cancer Genetics
Risk Assessment In The Primary Care Office : Identification Of Patients For Referral
Principals Of Cancer Risk Assessment And Genetic Counseling
Laboratory Methods In Cancer Genetics Testing
Breast Cancer
Gastrointestinal Polyposis Syndromes
Hereditary Non-Polyposis Colorectal Cancers
Risk Assessment And Clinical Management-- Uterine Cancer
Risk Assessment And Clinical Management-- Ovarian Cancer
Pancreatic Cancer Genetics
Risk Assessment and Clinical Management-- Genito-Urinary Tract Cancer
Genetic Predisposition To Gastric Cancer
Endocrine Cancers
Risk Assessment And Clinical Management-- Skin Cancer
Risk Assessment And Clinical Management-- Pediatric And Other Cancers
Ethical, Legal And Psychosocial Issues In Cancer Genetic Assessment And Genetic Test
Talking To Children And Family About Hereditary Cancer Risk And Genetic Test Results
Future Challenges And Opportunities In Clinical Cancer Genomics.

Summary: The book discusses cancer and the potential use of phytochemicals as cancer therapeutics. It begins with the basics of cancer, including the definition, types, etiology and molecular mechanisms involved, before discussing the fundamentals of diagnosis, treatment and associated problems as well as remedial measures. Since cancer is not a single disease, and the mechanisms of carcinogenesis are different for different cancers, it examines the genes and proteins involved in carcinogenesis, and signal transduction pathways for each individual cancer type. Further, the book reviews the latest research on phytochemicals for cancer treatment, highlighting their anti-cancer properties, sources, structure, active biomolecules and probable mechanisms of action, and describing their biochemical properties in the context of cancer prevention and treatment.

Contents:
Intro; Foreword; Preface; Contents; About the Authors; 1 Cancer: Types and Hallmarks; 1.1 What Is Cancer?; 1.1.1 Types of Cancer; 1.1.1.1 Carcinoma; 1.1.1.2 Sarcoma; 1.1.1.3 Leukemia; 1.1.1.4 Lymphoma; 1.1.1.5 Myeloma; 1.1.1.6 Melanoma; 1.1.1.7 Brain and Spinal Cord Tumors; 1.2 Hallmarks of Cancer; 1.2.1 Sustaining Proliferative Signaling; 1.2.2 Evading Growth Suppressors; 1.2.2.1 Disruption of Contact Inhibition; 1.2.3 Resisting Cell Death; 1.2.4 Enabling Replicative Immortality; 1.2.5 Inducing Angiogenesis; 1.2.6 Activating Invasion and Metastasis; 1.2.7 Reprogramming Energy Metabolism 1.2.8 Evading Immune Destruction1.2.9 Genetic Instability and Mutation; 1.2.10 Tumor-Promoting Inflammation; 1.3 Cancer Diagnosis and Treatment; 1.3.1 Risk Factors and Causes of Cancer; 1.3.2 Symptoms; 1.3.3 Diagnosis; 1.3.3.1 Biopsy; 1.3.3.2 Imaging; 1.3.4 Treatment; 1.4 Conclusion; References; 2 Cancer: Genetics and Important Pathways; 2.1 Introduction; 2.2 Degree of Gene Mutations in Tumorigenesis; 2.3 Driver and Passenger Mutations; 2.4 Cancer-Specific Genomic Landscapes; 2.4.1 Genomic Landscape of Breast Cancer; 2.4.1.1 Summary; 2.5 Genomic Landscape of Other Cancers 3.5 Classification of Phytochemicals3.5.1 Phenolics; 3.5.1.1 Phenolic Acids; 3.5.1.2 Tannins; 3.5.1.3 Stilbenes; 3.5.1.4 Coumarins; 3.5.2 Flavonoids; 3.5.3 Carotenoid; 3.5.4 Alkaloid; 3.5.5 Nitrogen-Containing Compounds; 3.5.6 Organosulfur Compounds; 3.5.7 Benefits of Dietary Phytochemicals; 3.6 Conclusion; References; 4 Drugs and Phytochemicals; 4.1 Introduction; 4.2 Classification of Chemotherapy Drugs; 4.2.1 Alkylating Agents; 4.2.2 Antimetabolites; 4.2.3 Antitumor Antibiotics; 4.2.4 Topoisomerase Inhibitors; 4.2.5 Mitotic Inhibitors; 4.2.6 Corticosteroids 4.3 Mode of Action of Chemotherapeutic Drugs4.4 Benefits of Plant-Derived Medicines; 4.5 Plant-Derived Anticancer Drugs; 4.6 Other Phytochemicals as Anticancer Agents; 4.7 Conclusion; References; 5 Molecular Mechanisms of Phytochemical Actions in Cancer; 5.1 Introduction; 5.2 Epigenetic Control; 5.2.1 Histone Modification; 5.2.2 DNA Methylation; 5.2.3 miRNAs; 5.3 Keap1-Nrf2 Pathway; 5.4 Oxidative Stress; 5.5 Inflammation; 5.6 Roles of Dietary Phytochemicals in Oxidative Stress; 5.6.1 Phytochemicals and Oxidative Stress; 5.6.1.1 Phenolic Phytochemicals and Oxidative Stress

Summary: Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment. Tools such as sidebars, key concept summaries, a glossary, and acronym and abbreviation definitions make this book highly accessible to researchers from several fields associated with cancer genomics.Contributions from thought leaders provide valuable historical perspective to relate the advances in the field to current technologies and literature.

Contents:
Genome-Wide Mapping Of RNA Pol-II Promoter Usage In Mouse Tissues By Chip-Seq
Using Native Chromatin Immunoprecipitation To Interrogate Histone Variant Protein Deposition In Embryonic Stem Cells
Reduced Representation Bisulfite Sequencing To Identify Global Alteration In The DNA Methylation
A High-Throughput Microrna Expression Profiling System
Using Pooled Mir30-Shrna Library For Cancer Lethal And Synthetic Lethal Screens
Genome-Wide RNA Interference Screening To Identify Regulators Of Epigenetic Silencing Of A Tumor Suppressor Gene
A Diphtheria Toxin Negative Selection In RNA Interference Screening
Cancer Metabolism: Crosstalk Between Signaling And O-Glcnacylation
Targeted Genome Modification Via Triple Helix Formation
Synthesis Of Stabilized Alpha-Helical Peptides
Arginine-Grafted Biodegradable Polymer: A Versatile Transfection Reagent For Both DNA And Sirna
Using Laco Arrays To Monitor DNA Double-Strand Break Dynamics In Live Schizosaccharomyces Pombe Cells
Zebrafish As A Platform To Study Tumor Progression
Clonal Screens To Find Modifiers Of Partially Penetrant Phenotypes In C. Elegans
Serum Profiling Using Protein Microarrays To Identify Disease Related Antigens
Interrogation Of In Vivo Protein-Protein Interactions Using Transgenic Mouse Models And Stable Isotope Labeling
New Biophysical Methods To Study The Membrane Activity Of Bcl-2 Proteins
Purification Of Recombinant 2XMBP Tagged Human Proteins From Human Cells
Computational Analysis In Cancer Exome Sequencing
Matrix Factorization Methods For Integrative Cancer Genomics
Computational Methods For DNA Copy-Number Analysis Of Tumors.

Summary: Cancer Immunology is intended as an up-to-date, clinically relevant review of cancer immunology and immunotherapy. The rapid flow of studies in the field of cancer immunology during the last decade has increased our understanding of the interactions between the immune system and cancerous cells. In particular, it is now well known that such interactions result in the induction of epigenetic changes in cancerous cells and the selection of less immunogenic clones as well as alterations in immune responses. Understanding the cross-talk between nascent transformed cells and cells of the immune system has led to the development of combinatorial immunotherapeutic strategies to combat cancer. This volume is focused on interactions between cancerous cells and various components of the innate and adaptive immune system are fully described. Notably, the principal focus is very much on clinical aspects, the aim being to educate clinicians on the clinical implications of the most recent findings and novel developments in the field. This is to be hoped that this translational book will be comprehensible, cogent and of special value for researchers and clinicians who wish to extend their knowledge on cancer immunology.

Contents:
Introduction on cancer immunology and immunotherapy
Inflammatory and innate immune cells in cancer microenvironment and progression
Role of innate immunity in cancers and antitumor response
Role of B cells in anti tumor response
The role of exhaustion in tumor-induced T cell dysfunction in patients with cancer
Regulatory T cells and Th17 cells in the immunosuppressive tumor network
Role of cytokines in tumor immunity and immune tolerance to cancers
Role of chemokines and chemokine receptors in cancers
The role of Fas and Fas-ligand in cancers
MHC class I molecules and cancer progression: Lessons learned from preclinical tumor models
Role of plasmacytoid dendritic cells in cancer
Cancer immunoediting: immunosurveillance, immuneequilibrium, and immune escape
Apoptosis, autophagy and necroptosis in Cancer
Prognostic value of innate and adaptive immunity in cancers
Epigenetics and Micro RNAs in cancers
Immunogenetics of cancers
Immunodeficiencies and cancers
Immunosenescence and cancers
Nutrition, immunity and cancers
Allergies and cancers
Cancer immunology of transmissible cancers
Systems biology and systems immunology of cancer
Principles of immunological diagnostic tests for cancers
Flow cytometry in cancer immunotherapy: applications, analysis, quality control and future
Immunohistochemistry of cancers
Immunology and immunotherapy of graft versus host disease. .

Summary: "This book focusing on the immunopathology of cancers is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Readers will find detailed descriptions of the interactions between cancerous cells and various components of the innate and adaptive immune system. The principal focus, however, is very much on clinical aspects, the aim being to educate clinicians in the clinical implications of the latest research and novel developments in the field. In the new edition of this very well received book, first published in 2015, the original chapters have been significantly updated and additional chapters included on, for example, current knowledge on the roles of T-helper cells and NK cells in tumor immunity, the part played by oncoviruses in the development of various cancers, and the applications of fluorescent in situ hybridization, bioluminescence, and cancer molecular and functional imaging"--Publisher's description.

Contents:
Introduction on cancer immunology and immunotherapy
Role of innate immunity in cancers and antitumor response
Tumor-associated myeloid cells in cancer progression
B-cells in cancer immunology: for or against cancer growth?
The roles of CD4+ T-cells in tumor immunity
Regulatory T-cells and Th cells in tumor microenvironment
T-cell metabolism and its dysfunction induced by cancer
The role of exhaustion in tumor-induced T-cell dysfunction in cancer
The role of NK cells in cancer
Role of plasmacytoid dendritic cells in cancer
The CD95/CD95L signaling pathway: a role in carcinogenesis
MHC class I molecules and cancer progression: lessons learned from preclinical mouse models
Role of cytokines in tumor immunity and immune tolerance to cancer
Role of chemokines and chemokine receptors in cancer
Role of the inflammasome in cancer
Cancer immunoediting: immunosurveillance, immune equilibrium, and immune escape
Apoptosis and cancer
Endoplasmic reticulum stress and autophagy in cancer
Prognostic value of innate and adaptive immunity in cancers
Immunogenetics of cancer
Epigenetics and MicroRNAs in cancer
The role of DNA methylation in cancer
Immunosenescence, oxidative stress, and cancers
Nutrition, immunity, and cancers
Inborn errors of immunity and cancers
Allergies and cancers
Envisioning the application of systems biology in cancer immunology
Principles of immunological diagnostic tests for cancers
Immunohistochemistry of cancers
Fluorescent in situ hybridization: methods and application in cancer diagnosis
Cancer molecular and functional imaging
Cancer imaging with radiolabeled monoclonal antibodies
Flow cytometry in cancer immunotherapy: applications, quality assurance, and future.

Summary: This translational book describes in detail the clinical application of novel approaches in cancer immunotherapy with the aim of educating clinicians in the implications of the most recent research and new developments in the field. The scope is broad, encompassing, for example, prognostic biomarkers for personalized cancer treatment, strategies for targeting tumor immunosuppression, gene therapy, virus-based vaccines, targeting of cancer stem cells, hematopoietic stem cell transplantation, the role of T lymphocytes in cancer immunotherapy, use of monoclonal antibodies, and many more innovative approaches. Clinical immunologists, hematologists, and oncologists in particular will find the book to be of value in expanding their knowledge. ℗ℓ The book is the second in a three-volume series, Cancer Immunology, which offers an up-to-date review of cancer immunology and immunotherapy. The remaining volumes focus on the immunopathology of cancers and cancer immunotherapy for organ-specific tumors. In total the series, designed for both clinicians and researchers, includes contributions from more than 250 scientists working at leading universities and institutes from across the world.

Contents:
Frontiers in Cancer Immunotherapy
Novel Strategy of Cancer Immunotherapy: Spiraling Up
Novel Prognostic Biomarkers for Personalized Cancer Treatments
Tumor Antigen and Epitope Identification for Pre-Clinical and Clinical Evaluation
Strategies to Target Tumor Immunesuppression
Immune Modulation of Drugs in Prevention and Treatment of Cancers
Overcoming Immune Tolerance With Immune Checkpoint Blockade
Gene therapy and Virus-Based Cancer Vaccines
Cancer Stem Cells: Biology and Potential therapeutic Applications
Hematopoietic Stem Cell Transplantation and Lymphodepletion in Treatment of Cancers
Combination of Chemotherapy and Cytokine Therapy in Treatment of Cancers
T Cell Immunotherapy: From Synthetic Biology to Clinical Practice
Role of Gamma-Delta T Lymphocytes in Cancer Immunosurveillance and Immunotherapy
Adoptive T Cell therapy: Optimizing Chemokine Receptor-Mediated Homing of T Cells in Cancer Immunotherapy
Cellular therapy of Cancer With B Effector Cells
Monoclonal Antibodies for Treatment of Cancers
Pattern Recognition Receptors in Cancers and Immunotherapy by Triggering or Targeting of Toll Like Receptors Pathway
Recent Advances in the Use of NK Cells Against Cancer
Dendritic Cell Vaccines for Cancer Therapy: Fundamentals and Clinical Trials
Tumor Associated Macrophages and iNOS in Cancer Immunotherapy
Photodynamic therapy and Anti-Tumor Immune Response
Polarization of Tumor Milieu: Therapeutic Implications
Immunotherapies Targeting 5T4 Oncofoetal Glycoprotein
Immune Monitoring During Clinical Development of Anti-CTLA-4 Antibody Therapy
PD-1 Blockade in Cancer Therapy
New Advances in Radioimmunotherapy for the Treatment of Cancers
Psychoneuroendocrinoimmunotherapy of Cancers
Ethical Considerations in Cancer Immunotherapy.

Summary: This translational, clinically oriented book describes in detail novel approaches to cancer immunotherapy, current strategies to target tumor immunosuppression, and prognostic biomarkers for personalized cancer treatments. Since the first, very successful edition of the book was published in 2015, the original chapters have been significantly updated and entirely new chapters are included on, for example, cancer immunoprevention, aptamer-mediated cancer gene therapy, haploidentical bone marrow transplantation for pediatric malignancies, and nanoimmunotherapy. The book is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Other volumes in the series address the translational medicine context and cancer immunotherapy for organ-specific tumors. Cancer Immunology: Bench to Bedside Immunotherapy of Cancers will be of special value to clinical immunologists, hematologists, and oncologists.

Contents:
Frontiers in Cancer Immunotherapy
Novel Strategy of Cancer Immunotherapy: Spiraling Up
Novel Prognostic Biomarkers for Personalized Cancer Treatments
Tumor Antigen and Epitope Identification for Pre-Clinical and Clinical Evaluation
Strategies to Target Tumor Immunesuppression
Immune Modulation of Drugs in Prevention and Treatment of Cancers
Overcoming Immune Tolerance With Immune Checkpoint Blockade
Gene therapy and Virus-Based Cancer Vaccines
Cancer Stem Cells: Biology and Potential therapeutic Applications
Hematopoietic Stem Cell Transplantation and Lymphodepletion in Treatment of Cancers
Combination of Chemotherapy and Cytokine Therapy in Treatment of Cancers
T Cell Immunotherapy: From Synthetic Biology to Clinical Practice
Role of Gamma-Delta T Lymphocytes in Cancer Immunosurveillance and Immunotherapy
Adoptive T Cell therapy: Optimizing Chemokine Receptor-Mediated Homing of T Cells in Cancer Immunotherapy
Cellular therapy of Cancer With B Effector Cells
Monoclonal Antibodies for Treatment of Cancers
Pattern Recognition Receptors in Cancers and Immunotherapy by Triggering or Targeting of Toll Like Receptors Pathway
Recent Advances in the Use of NK Cells Against Cancer
Dendritic Cell Vaccines for Cancer Therapy: Fundamentals and Clinical Trials
Tumor Associated Macrophages and iNOS in Cancer Immunotherapy
Photodynamic therapy and Anti-Tumor Immune Response
Polarization of Tumor Milieu: Therapeutic Implications
Immunotherapies Targeting 5T4 Oncofoetal Glycoprotein
Immune Monitoring During Clinical Development of Anti-CTLA-4 Antibody Therapy
PD-1 Blockade in Cancer Therapy
New Advances in Radioimmunotherapy for the Treatment of Cancers
Psychoneuroendocrinoimmunotherapy of Cancers
Ethical Considerations in Cancer Immunotherapy.

Contents:
Specific Organ Tumors: General Considerations On Immunotherapy
Vaccination Of Human Solid Tumors: Recent Progress In The Clinical Setting
Immunotherapy For Pediatric Solid Tumors
Immunopathology Of Hematological Cancers And Immunotherapy Of Leukemia And Multiple Myeloma
Immunopathology Of Lymphoma And Immunotherapy Of Hodgkin's Disease And Non-Hodgkin's Lymphoma
Cancer-Testis Antigens As Targets For The Immunotherapy Of Hematological Malignancies
Tumor Immunology And Immunotherapy Of Gastrointestinal Tract Cancers
Immunology And Immunotherapy Of Colorectal Cancer
Immunopathology Of Hepatobiliary Tumors And Immunotherapy Of Liver Cancers
Immunology And Immunotherapy Of Pancreatic Tumors
Immunology Of Cutaneous Tumors And Immunotherapy For Melanoma
Immunopathology Of Head And Neck Tumors And Immunotherapy Of Squamous Cell Carcinoma
Immunopathology And Immunotherapy Of Oral Cancers
Immunopathology Of Bone And Connective Tissue Cancers And Immunotherapy Of Sarcomas
Immunopathology Of Central Nervous System Cancers And Immunotherapy Of Brain Tumors
Immunology And Immunotherapy Of Pulmonary Tumors
Immunopathology Of Urinary System Cancers And Immunotherapy Of Renal And Bladder Cancers
Immunopathology Of Cancers Of Male And Female Genitalia Organs And Immunotherapy Of Cervical And Prostate Cancer
Immunology And Immunotherapy Of Ovarian Cancer
Revisiting Immunology For Breast Cancer
Immunology And Immunotherapy Of Graft Versus Host Disease.

Summary: This book explains the immunology of organ-specific malignancies and discusses novel immunotherapy strategies for their treatment. Since the first, very successful edition of the book was published in 2015, a number of entirely new chapters have been included. The range of cancers considered has accordingly been extended, with coverage of the latest immunotherapy approaches for skin cancers, ocular malignancies, endocrine malignancies, cardiac cancers, vascular cancers, and HPV-associated cancers. In addition, the original chapters have been updated to document the latest advances in immunotherapy for pediatric solid tumors, hematologic malignancies, gastrointestinal tumors, bone tumors, CNS tumors, lung cancer, genitourinary tract tumors, and breast cancer, among others. The book is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Other volumes in the series address the translational medicine context and bench to bedside immunotherapy. Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors will be of special value to clinical immunologists, hematologists, and oncologists. .

Contents:
Specific Organ Tumors: General Considerations On Immunotherapy
Vaccination Of Human Solid Tumors: Recent Progress In The Clinical Setting
Immunotherapy For Pediatric Solid Tumors
Immunopathology Of Hematological Cancers And Immunotherapy Of Leukemia And Multiple Myeloma
Immunopathology Of Lymphoma And Immunotherapy Of Hodgkin's Disease And Non-Hodgkin's Lymphoma
Cancer-Testis Antigens As Targets For The Immunotherapy Of Hematological Malignancies
Tumor Immunology And Immunotherapy Of Gastrointestinal Tract Cancers
Immunology And Immunotherapy Of Colorectal Cancer
Immunopathology Of Hepatobiliary Tumors And Immunotherapy Of Liver Cancers
Immunology And Immunotherapy Of Pancreatic Tumors
Immunology Of Cutaneous Tumors And Immunotherapy For Melanoma
Immunopathology Of Head And Neck Tumors And Immunotherapy Of Squamous Cell Carcinoma
Immunopathology And Immunotherapy Of Oral Cancers
Immunopathology Of Bone And Connective Tissue Cancers And Immunotherapy Of Sarcomas
Immunopathology Of Central Nervous System Cancers And Immunotherapy Of Brain Tumors
Immunology And Immunotherapy Of Pulmonary Tumors
Immunopathology Of Urinary System Cancers And Immunotherapy Of Renal And Bladder Cancers
Immunopathology Of Cancers Of Male And Female Genitalia Organs And Immunotherapy Of Cervical And Prostate Cancer
Immunology And Immunotherapy Of Ovarian Cancer
Revisiting Immunology For Breast Cancer
Immunology And Immunotherapy Of Graft Versus Host Disease.

Summary: This book presents the clinical scope of cancer immunotherapeutic agents for solid tumors and Hematologic malignancies, elaborates on the scientific details of their modes of action, and presents the impact of these agents on oncology, patients and the broader healthcare system. At present, cancer immunotherapies fall broadly into three categories: immune checkpoint inhibitors (ICIs), adoptive T cell therapies, and cancer vaccines which have distinct mechanisms of action. Immune checkpoint inhibitors rely upon disrupting tumor antigen recognition as self by the immune system through inhibition of checkpoint molecules. Adoptive T cell therapies involve the engineering of T cells ex vivo to target and destroy tumor cells. The first part of this book will provide an overview of the discovery and mechanistic details of the technology. The second part will be devoted to elaborating on the clinical outcomes, successes and limitations for specific tumor subtypes, which includes both solid tumors and hematologic malignances for both pediatric and adult populations. As such, the book offers a valuable resource for oncologists, hematologists, and all those seeking an up-to-date overview of cancer immunotherapies.

Contents:
Development of Cancer Immunotherapies
Melanoma
Engaging pattern recognition receptors in solid tumors to generate systemic anti-tumor immunity
Allogeneic tumor antigen-specific T cells for broadly applicable adoptive cell therapy of cancer
Chimeric Antigen Receptor (CAR) T Cell Therapy for Glioblastoma
Lag3: From Bench to Bedside
Immunotherapy in Genitourinary Malignancy: evolution in revolution or revolution in evolution
Immune-based therapeutic interventions for Acute Myeloid Leukemia.-Off-the-shelf chimeric antigen receptor immune cells from human pluripotent stem cells
The single-cell level perspective of the tumor microenvironment and its remodeling by CAR-T cells
Clinical Development and Therapeutic Applications of Bispecific Antibodies for Hematological Malignancies.

Summary: This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical development of new approaches and to pinpoint the optimal treatment for each patient. The book acknowledges the continuing dynamic nature of the field as reflected in the development of next-generation immunotherapies that are already in clinical testing. Cancer Immunotherapy Meets Oncology is dedicated to the lifetime achievements of Christoph Huber, founder and chair of the Association for Cancer Immunotherapy (CIMT). It is also a tribute to those researchers and clinicians who are striving to develop novel diagnostics and tailored immunotherapies for the benefit of cancer patients.

Contents:
Part I. Immunological and Regulatory Framework for Immuno-oncology
From Basic Immunology to New Therapies for Cancer Patients / Hans-Georg Rammensee
How T Cells Single Out Tumor Cells: "And That Has Made All the Difference...: / Marit M. van Buuren, Pia Kvistborg, and Ton N.M. Schumacher
Effects of Regulatory T Cell-Dendritic Cell Interactions on Adaptive Immune Responses / Tobias Bopp, Hans Christian Probst, Markus Radsak, Edgar Schmitt, Michael Stassen, Hansjörg Schild, and Stefan Tenzer
Evolution of the Regulatory Landscape for Immunomodulatory Compounds and Personalized Therapeutic Cancer Vaccines / Cedrik Michael Britten, Thomas Hinz, Harpreet Singh-Jasuja, and Ulrich Kalinke
Immunoguiding, the Final Frontier in the Immunotherapy of Cancer / Sjoerd H. van der Burg, Steffen Walter, Sylvia Janetzki, Cedrik Michael Britten, Jérôme Galon, Marij J.P. Welters, and Cécile Gouttefangeas
Developing Cancer Immunotherapies as Drugs: Setting the Stage Through Methodological Progress / Axel Hoos
Part II. Immunotherapies
Reflections on Cancer Vaccines / Cornelis J.M. Melief
Dendritic Cell-Based Cancer Vaccines / H. Westdorp, K.F. Bol, M. Coşkuntürk, G. Schreibelt, I.J.M. de Vries, and C.G. Figdor
mRNA Vaccination and Personalized Cancer Therapy / S. Kreiter, M. Diken, and U. Sahin
Antibody Therapy in Oncology / Martin Glennie, Özlem Türeci, and Peter W.M. Johnson
Bispecific Antibodies for the Treatment of Cancer: The Challenges of Translation / Gundram Jung and Ludger Grosse-Hovest
The ABCs of T Cell Receptor Gene Therapy / Dolores J. Schendel and Philip D. Greenberg
The Express Drivers: Chimeric Antigen Receptor-Redirected T Cells Make It to the Clinic / Hinrich Abken, Winfried S. Wels, and Klaus Kühlcke
Part III. Cancer Entities
Immunotherapy of Malignant Melanoma / Cedrik Michael Britten, G. Schuler, and S. Grabbe
Prostate Cancer Vaccines Generated with the Disruptive RNActive® Technology Follow the Path Paved by Sipuleucel-T and Prostvac-VF / Karl-Josef Kallen
Recent Developments in the Active Immunotherapy of Renal Cell Cancer / Harpreet Singh-Jasuja
Current Status of Immunotherapy in Gastroesophageal Cancer / Stefan Kasper and Martin Schuler
Non-small Cell Lung Cancer, NSCLC / Jens-Peter Marschner, Sonia Quaratino, and Ulf Forssmann
Towards More Specificity and Effectivity in the Antileukemia Immune Response / Udo F. Hartwig, Ralf G. Meyer, and Wolfgang Herr
Part IV. Biomarkers
Molecular and Metabolic Cues of the Key-Lock Paradigm Dictating Immunogenic Cell Death / Jonathan M. Pitt, Marie Vetizou, Oliver Kepp, Guido Kroemer, and Laurence Zitvogel
Pathogenesis of Minimal Residual Disease: CTCs as Novel Biomarkers in Cancer Disease / Tobias M. Gorges and Klaus Pantel
Genomics Meets Cancer Immunotherapy / John C. Castle, Sebastian Boegel, Thomas Bukur, Valesca Boisguerin, and Martin Loewer
Part V. Featured Chapters
Oncolytic Viruses / Michael D. Mühlebach and Stefan Hutzler
Part VI. Final Remarks
Final Words / Cedrik Michael Britten, Mustafa Diken, Sebastian Kreiter, and Hans-Georg Rammensee.

Summary: This is the second edition of the only book to be devoted exclusively to the total cancer picture in adolescents and young adults (AYA), now expanded from the age range 15-29 to that of 15-39 years. For each of the diverse spectrum of cancers encountered in the AYA group, the epidemiology, natural progression, diagnostic approaches, and treatment options are described, with special emphasis on strategies for early detection and prevention. Comparison is made with management of both younger and older patients, and model programs are presented that address common diagnostic, staging, treatment, and psychosocial shortcomings in the AYA group. Detailed attention is also paid to principles and practices of care, with consideration of psychosocial and quality of life issues, social support systems, rehabilitation, late effects, insurance, and economic aspects of health care, among other topics. The authors make compelling arguments for integrated strategies that allow young adults to benefit from the combined expertise of pediatric and adult oncologists in systems that identify both the complex disease and the social issues specific to this population. The proposed models of care include relationships with other specialties that do not specifically target this age group, i.e., infectious disease, endocrinology, pulmonary medicine, nephrology, gastroenterology, thoracic and abdominal surgery, urology, otolaryngology, and neurosurgery. New patterns of communication are advocated and endorsed as essential for productive interaction involving these specialties. References are extensive and are oriented toward users in pediatric hematology-oncology medical oncology, radiation oncology, surgical oncology, gynecologic oncology, oncology nursing, psycho-oncology, social work, epidemiology, public health and health services research. The contributing authors are from the United States, the United Kingdom, Canada, Italy, France, Israel, Switzerland and Australia, Germany, Japan and the Netherlands. .

Summary: This book discusses the current state of cancer pathway as it is relevant to sub-Saharan Africa and highlights differences in epidemiology and the underlying problems with management. It outlines the current practice and opinions in all forms of cancer, also highlighting future prospects. Starting by providing background information on the epidemiology and genomic variations, the book then goes on to look at Infection-related cancers and continues to prostate GI, breast cancer and ovarian and cervical cancer. The last part of the book focuses on delivery of affordable and accessible care. Palliative services and primary and transnational research, as well as clinical trials are also discussed. Written by a team of authors based in the UK, Nigeria, South Africa and the US. this book offers an overview of the current state and challenges of cancer care in sub-Saharan Africa, and it would be valuable to policy makers, researchers, funding organisations, and can be an adjunct to standard text books for students, residents and established doctors.

Summary: This is an Open Access book. This book is a must-have for healthcare providers and researchers, public health specialists and policy makers who are interested and involved in cancer care in the Arab world. The Arab world consists of 22 countries, which are members of the Arab League and spanning over 13,132,327 km2 with over 423,000,000 population. Over the past few decades, the Arab world has witnessed a swift evolution in healthcare provision. Nonetheless, Arab countries have considerable variability in economic capabilities, resource allocation, and intellectual talent that inevitably reflect on access to modern cancer care and prevention. This book is authored by experts from the Arab world who provide vital information on cancer statistics and risk factors, available clinical care pathways and infrastructure, and prevention programs in their individual countries. The chapters also address specific challenges in each country and insights into future directions to achieve optimal care with conventional and novel diagnostics and therapies to keep up with the era of precision medicine. Special topics of interest and unique to the Arab world are also discussed, such as out of the country's medical tourism for cancer care and cancer care during war and conflict. Other special chapters include: Cancer research in the Arab world, Radiation therapy in Arab World and Pediatric Oncology in the Arab World Cancer in the Arab World is the first comprehensive book that addresses cancer care in depth in all Arab countries and it is endorsed by the prestigious Emirates Oncology Society.

Contents:
1 Introduction
2 General Oncology Care in Algeria
3 General Oncology Care in Bahrain
4 General Oncology Care in Egypt
5 General Oncology Care in Iraq
6 General Oncology Care in Jordan
7 General Oncology Care in Kuwait
8 General Oncology Care in Lebanon
9 General Oncology Care in Libya
10 General Oncology Care in Mauritania
11 General Oncology Care in Morocco
12 General Oncology Care in Oman
13 General Oncology Care in Palestine
14 General Oncology Care in the Kingdom of Saudi Arabia
15 General Oncology Care in Somalia
16 General Oncology Care in Sudan
17 General Oncology Care in Syria
18 General Oncology Care in Tunisia
19 General oncology care in the UAE
20 General Oncology Care in the Republic of Yemen
21 General Oncology Care in Qatar, Comoros & Djibouti
22 Breast Cancer in the Arab World
23 Colorectal Cancer in the Arab World
24 Palliative Care in the Arab World
25 Cancer Research in the Arab World
26 Pediatric Oncology in the Arab World
27 Challenges Associated with Medical Travel for Cancer Patients in the Arab World: A Systematic Review
28 Radiation Therapy in Arab World
29 Cancer Care During War and Conflict.

Contents:
Principles of diagnosis and therapy in traditional Chinese medicine
Herbs and prescriptions for therapy
Cancer prevention and treatment using TCM
Major forms of cancer and case studies
Diet, exercise, and health cultivation.

Summary: Cancer metabolomics is a rapidly evolving field that aims for a comprehensive dissection of the metabolic phenotypes and functional network of metabolites in human cancers. State of the art metabolomics tools have been developed and applied to studying cancer metabolism and developing metabolic targets for improved diagnosis, prognosis and therapeutic treatment of human cancers. Chapters are written by subject experts in the field of cancer metabolomics with cross-disciplinary contributions. Coverage includes advanced metabolomics technologies and methodologies, including chemical isotope labelling liquid chromatography - mass spectrometry, capillary ion chromatography - mass spectrometry, 2-D gas chromatography - mass spectrometry, capillary electrophoresis - mass spectrometry, nuclear magnetic resonance spectroscopy, shotgun lipidomics, tracer-based metabolomics, microbial metabolomics, mass spectrometry imaging for single cell metabolomics and functional metabolomics. In addition, the book highlights new discoveries in cancer metabolism such as hypoxia inducible factor pathway, isocitrate dehydrogenase 1 mutation and oncometabolites. Finally, contributors focus on the translational applications of metabolomics in human cancers such as glioma, head and neck cancer, and gastric cancer. This new volume will be a unique reference source for cancer researchers and promote applications of metabolomics in understanding cancer metabolism.

Contents:
Chapter 1. Exosomes as theranostics for lung cancer
Chapter 2. Nanotechnology approaches to improving cancer immunotherapy
Chapter 3. Ultrasound contrast agents and delivery systems in cancer detection and therapy
Chapter 4. Dendronized systems for the delivery of chemotherapeutics
Chapter 5. Thermosensitive liposomes for image-guided drug delivery
Chapter 6. Supramolecular analytical chemistry in cancer research
Chapter 7. Gold nanoparticles for the delivery of cancer therapeutics
Chapter 8. Single-cell proteomics for cancer immunotherapy.

Contents:
Cancer nanotechnology : opportunities for prevention, diagnosis, and therapy / Reema Zeineldin and Joan Syoufjy
Improved targeting of cancers with nanotherapeutics / Christian Foster, Andre Watson, Joseph Kaplinsky, and Nazila Kamaly
Multifunctional liposomes / Bhawani Aryasomayajula, Giuseppina Salzano, and Vladimir P. Torchilin
Multifunctional concentric FRET-quantum dot probes for tracking and imaging of proteolytic activity / Melissa Massey, Jia Jun Li, and W. Russ Algar
Preparation and characterization of magnetic nano-in-microparticles for pulmonary delivery / Amber A. McBride, Dominique N. Price, and Pavan Muttil
Multifunctionalization of gold nanoshells / Sandra W. Bishnoi and Yujen Lin
Fabrication of photothermal stable gold nanosphere/mesoporous silica hybrid nanoparticle responsive to near-infrared light / Bei Cheng and Peisheng Xu
Engineering well-characterized PEG-coated nanoparticles for elucidating biological barriers to drug delivery / Qi Yang and Samuel K. Lai
Piloting your nanovehicle to overcome biological barriers / Steven M. Richards and Robert B. Campbell
Detecting sonolysis of polyethylene glycol upon functionalizing carbon nanotubes / Ruhung Wang, Vasanth S. Murali, and Rockford Draper
Methods for generation and detection of nonstationary vapor nanobubbles around plasmonic nanoparticles / Ekaterina Y. Lukianova-Hleb and Dmitri O. Lapotko
Force measurements for cancer cells / Vivek Rajasekharan, Varun K.A. Sreenivasan, and Brenda Farrell
Fractal analysis of cancer cell surface / Igor Sokolov and Maxim E. Dokukin
Quantitative evaluation of the enhanced permeability and retention (EPR) effect / Luisa M. Russell, Charlene M. Dawidczyk, and Peter C. Searson
Nanotechnology-based cancer vaccine / Aws Alshamsan
Designing multicomponent nanosystems for rapid detection of circulating tumor cells / Shashwat S. Banerjee, Vrushali Khobragade, and Jayant Khandare
Fluorescence and bioluminescence imaging of orthotopic brain tumors in mice / Emilie McKinnon, Alfred Moore, Suraj Dixit, Yun Zhu, and Ann-Marie Broome
Ultrasensitive biosensing platform employing acetylcholinesterase and gold nanoparticles / Dingbin Liu and Xiaoyuan Chen
Gene silencing using multifunctionalized gold nanoparticles for cancer therapy / Alexandra R. Fernandes and Pedro V. Baptista
Generation of dose-response curves and improved IC50s for PARP inhibitor nanoformulations / Paige Baldwin, Shifalika Tangutoori, and Srinivas Sridhar
Artificial antigen-presenting cells for immunotherapies / Alyssa L. Siefert, Tarek M. Fahmy, and Dongin Kim
Exploiting uptake of nanoparticles by phagocytes for cancer treatment / Mee Rie Sheen and Steven Fiering
Pulmonary delivery of magnetically targeted nano-in-microparticles / Amber A. McBride, Dominique N. Price, and Pavan Muttil
Neutron-activatable nanoparticles for intraperitoneal radiation therapy / Derek Hargrove and Xiuling Lu
Nanoparticle-mediated x-ray radiation enhancement for cancer therapy / Autumn D. Paro, Ilanchezhian Shanmugam, and Anne L. van de Ven
Radiosensitizing silica nanoparticles encapsulating docetaxel for treatment of prostate cancer / Jodi Belz, Noelle Castilla-Ojo, Srinivas Sridhar, and Rajiv Kumar.

Summary: "This updated edition provides clinicians from various backgrounds and levels of training the information needed to optimally diagnose and manage neurologic complications of the nervous system. Organized into seven sections, this comprehensive volume begins with an overview of diagnostic studies for neurologic complications involving the nervous system. That is followed by sections on metastatic and non-metastatic complications of cancer involving the nervous system, and the interpretation, diagnosis, and management of common neuro-oncologic symptoms. The next section reviews the neurologic complications of cancer therapy, including corticosteroids, radiation therapy, chemotherapy, targeted molecular therapies, immunotherapies, hematopoietic stem cell transplantation, and infections involving the nervous system. The final section focuses on the most important neurologic complications in cancers arising from specific organs. In addition to capturing the latest advancements in the rapidly evolving fields of oncology and cancer neurology, the goal of this resource is to lead clinicians toward prompt diagnosis and intervention in order to improve patient quality of life"--Publisher's description.

Contents:
Part I: Overview. The prevalence and impact of neurological disease in cancer
Part II: Diagnostic studies. Imaging neurologic manifestations of oncologic disease
Other diagnostic tools for neurological disease in cancer: EEG, EMG, and lumbar puncture
Part III: Nervous system involvement of systemic cancers. Brain metastasis as complication of systemic cancers
Leptomeningeal metastasis as complication of systemic cancers
Spinal metastasis as complication of systemic cancers
Peripheral nervous system metastases as complications of systemic cancers
Part IV: Neurological complications of cancer. Headache as complication of cancer
Seizures as complications in cancer
Cerebrovascular complications of cancer
Elevated intracranial pressure and hydrocephalus in brain tumor patients
Cognitive dysfunction, mood disorders, and fatigue as complications of cancer
Paraneoplastic syndromes of the nervous system as complications of cancer
Part V: Neurological complications of cancer therapy
Neurologic complications of radiation therapy
Neurological complications of chemotherapy
Neurological complications of targeted therapies
Neurological complications of immune-based therapies
Neurological complications of hematopoietic stem cell transplantation
Neurologic complications of corticosteroids in cancer therapy
Central nervous system infections in patients receiving cancer therapies
Part VI: Neurological complications of specific malignancies. Neurological complications of primary brain tumors
Neurological complications of lung cancer
Neurological complications of breast cancer and its treatment
Neurological complications of gastrointestinal cancer
Neurologic complications of genitourinary cancer
Neurologic complications of female reproductive tract cancers
Neurological complications of sarcomas
Neurological complications of head and neck cancer
Neurological complications of malignant melanoma
Neurological complications of leukemia
Neurologic complications of lymphoma
Neurologic complications of plasma cell dyscrasias
Neurologic complications of pediatric systemic cancer
Part VII: Neurological complications in long term cancer survivors. Neurological complications of cancer and cancer therapies in long term survivors.

Summary: "Cancer Nursing: Principles and Practice, Eighth Edition continues as the gold standard in oncology nursing. With contributions from the foremost experts in the field, it has remained the definitive reference on the rapidly changing science and practice of oncology nursing for more than 25 years. Completely updated and revised to reflect the latest research and developments in the care of patients with cancer, the Eighth Edition includes new chapters on the biology of cancer, sleep disorders, and palliative care across the cancer continuum.The Eighth Edition also includes significant updates to the basic science chapters to reflect recent increases in scientific knowledge, especially relating to genes and cancer. Also heavily revised are the sections devoted to the dynamics of cancer prevention, detection, and diagnosis, as well as treatment, oncologic emergencies, end of life care, and professional and legal issues for oncology nurses. In addition, it provides extensive and current information on breast cancer, including two separate chapters on early stage breast cancer and metastatic breast cancer, and careful attention to survivorship issues." [Jones & Bartlett Learning].

Contents:
pt. I: The cancer problem
pt. II: Prevention, detection, and diagnosis
pt. III: Treatment
pt. IV: Cancer symptom management
pt. V: Oncologic emergencies
pt. VI: The care of individuals with specific cancers
pt. VII: Dimensions of cancer survivorship
pt. VIII: Palliative and end of life
pt. IX: Professional issues for the cancer nurse.

Contents:
Preface
1. Evidence-Based Medicine
2. Oral Cavity
3. Oropharynx
4. Nasopharynx
5. Hypopharynx
6. Larynx
Index.

Contents:
Part I: Principles of oncology. The cancer genome
Hallmarks of cancer: an organizing principle for cancer medicine
Molecular methods in cancer
Part II: Etiology and epidemiology of cancer. Tobacco
Oncogenic viruses
Inflammation
Chemical factors
Physical factors
Dietary factors
Obesity and physical activity
Section 2: Epidemiology of cancer. Epidemiologic methods
Trends in United States cancer mortality
Part III: Cancer therapeutics. Essentials of radiation therapy
Cancer immunotherapy
Pharmacokinetics and pharmacodynamics of anticancer drugs
Pharmacogenomics
Alkylating agents
Platinum analogs
Antimetabolites
Topoisomerase interactive agents
Antimicrotubule agents
Kinase inhibitors as anticancer drugs
Histone deacetylase inhibitors and demethylating agents
Proteasome inhibitors
Poly (ADP-ribose) polymerase inhibitors
Miscellaneous chemotherapeutic agents
Hormonal agents
Antiangiogenesis agents
Monoclonal antibodies
Assessment of clinical response
Part IV: Cancer prevention and screening. Tobacco use and the cancer patient
Role of surgery in cancer prevention
Cancer risk-reducing agents
Cancer screening
Genetic counseling
Part V: Cancer of the skin. Cancer of the skin
Molecular biology of cutaneous melanoma
Cutaneous melanoma
Genetic testing in skin cancer.

Summary: This book presents an up-to-date and thorough overview of cancer of unknown primary, encompassing topics ranging from epidemiology, tumor biology, and prognostic factors through to the most recent diagnostic and therapeutic advances. All aspects of management are covered, including radiological, nuclear medicine, and pathological diagnosis, site-specific therapies, platinum-based combination chemotherapy, radiotherapy, and novel targeted treatments. Clear guidance is offered on diagnosis of the tissue of origin by means of gene expression and micro-RNA analyses and its therapeutic implications. Detailed directions are also provided on the identification of subsets of patients with a more favorable prognosis, in whom specific treatment offers the chance of long-term survival or even cure. Readers will find Cancer of Unknown Primary to be an ideal source of practically oriented information that will assist in delivery of the best possible care for patients with this challenging diagnosis. .

Contents:
Introduction.- Epidemiology, risk factors and survival in CUP: pointers to disease mechanisms
Biologic features of CUP
Prognostic factors and their role in the management of CUP
Diagnostic work-up of CUP
an approach to current recommendations and underlying evidence
The radiologist's approach to CUP
Cancer of unknown primary: the pathologist's approach
Treatment of disseminated CUP
Concepts of radiotherapy in cancer of unknown primary
Favorable subsets of CUP
Novel Diagnostic and Therapeutic Strategies in the Management of Patients with Cancers of Unknown Primary Site
Future directions.

Contents:
Microtubule inhibitors
Alkylating agents
Enzyme inhibitors : topoisomerase I inhibitors
Enzyme inhibitors : topoisomerase II inhibitors
Antimetabolites
Monoclonal antibodies
VEGF trap
Tyrosine kinase inhibitors
Anti-androgen therapies
Mammalian target of rapamycin (MTOR) inhibitors
Histone deacetylase (HDAC) inhibitors
Hypomethylating agents
Proteasome inhibitors
Immunomodulatory agents
L-asparaginase enzymes
Promyelocytic leukemia gene retinoic acid receptor-alpha (PMI-RARA)translocation inhibitors
Sipuleucel-T(Provenge®)
Omacetaxine (Synribo®)
Estramustine (Emcyt®).

Summary: Cancer Policy: Pharmaceutical Safety provides invaluable information on the interesting and compelling field of cancer drug safety. Identifying and understanding high-priority policy issues and key pharmacovigilance strategies is of paramount importance. In this volume, outstanding and original chapters provide an overview and synthesis of the latest thoughts and findings relating to drug safety in the cancer domain. Topics include natural language processing and pharmacovigilance of alternative cancer pharmaceuticals. The information presented in this volume will improve understanding of emerging strategies to identify adverse drug reactions and drug-drug interactions within the cancer setting and will highlight policies that have been instituted to improve cancer patient safety. In summary, Cancer Policy: Pharmaceutical Safety explores many of the important areas of pharmacovigilance research in oncology.

Contents:
1. Impact of cost on the safety of cancer pharmaceuticals
2. Cancer comorbidity: implications for drug safety
3. Pharmacovigilance of alternative medications in the cancer setting
4. Key elements in adverse drug reactions safety signals: application of legal strategies
5. Biosimilars: are they really safe?
6. The drug shortage crisis in the United States: impact on cancer pharmaceutical safety
7. Anatomy of risk evaluation and mitigation strategies (REMS)
8. Cancer drug toxicity: moving from patient to survivor
9. Moonshot to cancer cure: recruiting policy to break down silos.

Contents:
Combining computational and experimental methods for identifying molecular targets of phytochemicals / Ann M. Bode and Zigang Dong
Common methods used for the discovery of natural anticancer compounds / Min Tang ... [et al.]
Nrf2-target approaches in cancer chemoprevention mediated by dietary phytochemicals / Francisco Fuentes ... [et al.]
Methods to analyze chemopreventive effect of silibinin on prostate cancer biomarkers protein expression / Gagan Deep, Swetha Inturi, and Rajesh Agarwal
Approach to the evaluation of berries for cancer prevention with emphasis on esophageal cancer / Gary D. Stoner ... [et al.]
Use of mouse models for lung cancer chemoprevention studies / Yian Wang ... [et al.]
Azoxymethane plus dextran sulfate sodium-induced mouse colon cancer model for the study of dietary chemoprevention of inflammation-associated carcinogenesis / Ha-Na Lee, Hye-Won Yum, and Young-Joon Surh
Use of seahorse extracellular flux analyzer in mechanistic studies of naturally occurring cancer chemopreventive agents / Michelle B. Moura ... [et al.]
Utilizing RNA-seq to define phytochemical-induced alterations in insulin and IGF-regulated transcriptomes / Heather Beckwith and Douglas Yee
Ex vivo use of keratinocytes from adult mice to define stem cell activities in cancer research / Rebecca J. Morris ... [et al.]
Quantitation of acetaldehyde-DNA adducts : biomarkers of alcohol consumption / Silvia Balbo and Stephen S. Hecht
Imaging tools in discovery and development of phytochemical chemopreventive agents / Marna Ericson
Designing the chemoprevention trials of tomorrow : applying lessons learned from past definitive trials / Karen Colbert Maresso and Ernest Hawk.

Summary: This book is a state-of-the-art overview of cancer regional therapy (CRT) for the surgeons and interventional radiologists active in CRT development and research. The goals of this book are 1) to review the theory and practice of cancer regional therapies including pharmacology, devices, techniques, and workflow, 2) illustrate the most common procedures performed in the interventional and operating rooms, and 3) discuss data supporting use of CRT. This is meant to be a definitive text on the theory and practice of CRT. It begins with a summary of the history, technical principles that underlie regional therapy. The following parts discuss current data and practice in peritoneal, liver, limb, pleural and other sites. Included in the practice are considerations of workflow and financial issues revolving around CRT. Novel techniques and therapies under investigation are presented to inform the direction of the field. Cancer Regional Therapy summarizes the history, current technology, common procedures, and future prospects in this field and includes procedures from many surgical and interventional radiologic disciplines.

Contents:
The Basis of Regional Therapy, Pharmacology, Hyperthermia, and Drug Resistance
Novel Biological Therapies with Direct Application to the Peritoneal Cavity
Y-90 Radiomicrosphere Therapy: Principles and Clinical Use in Colorectal Cancer Liver Metastases
Principles of Percutaneous Ablation in the Liver
Regional Gene Therapy for Cancer
Historical Perspective for Regional Peritoneal Therapy: HIPEC, EPIC and Port-based Therapy
Rationale Behind HIPEC/Molecular and Genetic Considerations in HIPEC
Data for HIPEC for Pseudomyxoma Peritonei/Tumors of the Appendix
Data for HIPEC in Colorectal Cancer (T4 Lesions and Metastases)
Role of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in the Treatment of Peritoneal Metastasis of Gastric Cancer
Regional Therapy for the Treatment of Ovarian Cancer: HIPEC and Intraperitoneal Chemotherapy
Mesothelioma and Miscellaneous Disease Processes
Anesthetic Considerations for Regional Therapies
Post-Operative Management of Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Complications of Cytoreductive Surgery and HIPEC
Liver Resection and HIPEC
Peritoneal Perfusion Techniques
Operative Pearls for Cytoreduction of the Difficult Abdomen and Pelvis
Novel Techniques and the Future of HIPEC (Immunotherapy, Viral Therapy)
Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC).

Summary: Finally, a concise pocket guide designed as a quick reference for busy clinicians who seek to improve the care they provide to cancer patients and cancer survivors. It is a comprehensive text formatted for fast access to a wide range of clinical information. This compact compendium is conveniently organized by cancer type for rapid review. It describes the many issues that cancer patients may face throughout the chronologic spectrum of care, starting from cancer diagnosis, to treatment, and survivorship. Each chapter helpfully highlights common impairments and treatment options using succinct tables, helpful illustrations and clinical peals from experts in the field. In addition, each chapter contains a clinical case and questions on the material to enhance understanding. Evidence for exercise treatment, including pertinent exercise precautions, is included, as are innovative research topics and emerging treatments. This includes dedicated chapters covering cancers of the breast; digestive organs; brain, eye, and central nervous system; urinary tract and genital organs; lip, oral cavity, and pharynx; lymphoid, hematopoietic, and related tissues; bone, articular cartilage, and soft tissues; respiratory and intrathoracic organs; skin. Thankfully, advances in cancer care such as chemotherapy, radiation, and surgery mean that more people than ever before are surviving long after their cancer diagnosis. Unfortunately, a large fraction of them live with at least one serious impairment as a consequence of their treatments that seriously impacts their ability to function and quality of life. This concise and essential guide to cancer rehabilitation will help the clinician navigate the care of this often complex population.

Contents:
Introduction: Impairment-based Cancer Rehabilitation by Type of Cancer
Breast Cancer: Evidence along Continuum of Care-Prehab through Rehab
Cancer of the Digestive Organs: Importance of Mobility for Motility
Cancer of the Brain, Eye, and other Parts of the Central Nervous System: Asymmetric Weakness, Cognition, Vision
Cancer of the Urinary Tract and Genital Organs: Female and Male
Cancer of the Lip, Oral Cavity, and Pharynx: Disorders of Communication and Swallowing
Cancer of the Lymphoid, Hematopietic, and Related Tissue: Infection Prevention, Exercise Precautions
Cancer of the Bone, Articular Cartilage, Mesothelial and Soft Tissue: Limb Salvage and Amputation
Cancer of the Respiratory and Intrathoracic Organs: Endurance
Cancer of the Skin: Prevention Data
Conclusion: Innovative Research.

Summary: Cancer-related fatigue (CrF) is increasingly recognized as a significant problem for patients with cancer at all stages, including those undergoing therapy and in remission. In fact, studies have shown that CrF causes patients more distress than pain, nausea, or vomiting and yet fatigue is still often undertreated and rarely studied. However, several new treatments such as are being investigated to determine the most effective ways to manage this debilitating symptom and improve patient quality of life. Cancer-Related Fatigue will provide a concise overview of this condition, with an evidence-based discussion of diagnosis, treatment, and long-term management.

Contents:
Introduction
Etiology and pathogenetic factors
Nonpharmacological treatment of cancer-related fatigue
Pharmacological treatment of cancer-related fatigue
Recommendations for the management of cancer-related fatigue.

Contents:
1.Introduction: the need to conduct cancer research in developing countries
2.Steps of a research study: from research question to publication
3.Types of research designs
4.Clinical research in developing countries: An overview
5.The research protocol
6.Ethics of conducting cancer research in developing countries
7.Data management and statistics
8.Funding For Cancer Research and Clinical Studies in Low and Middle-Income Countries
9.International Collaboration in Cancer Research
10.Publication and dissemination of research findings.

Summary: In the last decade, researchers working in the field of cancer biology have shifted their focus from genetic defects to epigenetic dysregulation, especially that of non-coding RNAs (ncRNAs). This book encompasses a comprehensive review of the transcriptional landscape of the cell and its involvement in the cancer pathophysiology. The first two chapters elucidate the basics of biosynthesis, mechanism of action and modulation of the epigenetic regulation of gene expression by coding as well as non-coding RNAs. The third chapter discusses the aberrant expression of the cellular RNome in the cancer cells and highlights its role in the orchestration of processes involved in evolution as well as the sustenance of cancer cells. The fourth chapter describes the recent advances in the field of translating the transcriptome into diagnostic/prognostic biomarkers and as targets for novel anti-cancer therapies. The final chapter then reviews the emerging experimental approaches to screen, identify and explore the functions of ncRNAs. Providing valuable insights into the field of RNome in the context of cancer, this book is helpful to students, researchers and clinicians.

Contents:
1. Section 1. RNome: Evolution and nature
Chapter. 1.1. RNA world hypothesis
Chapter. 1.2. Various classes of RNAs (coding as well non-coding), their biosynthesis and basic functions
2. Section 2. Cellular RNome: Chromatin dynamics
Chapter. 2.1. Chromatin modifications & transcription
Chapter. 2.2. RNA modifications and epitranscriptomics
Chapter. 2.3. Cellular RNome: Contribution of non-coding RNA
3. Section 3. Cancer RNome: Evolution and Sustenance.(How is cancer RNome different from RNome of healthy cell? How does the cancer RNome regulate the evolution as well as the sustenance of cancer?)
Chapter. 3.1. Genome instability and mutation
Chapter. 3.2. Tumor-promoting inflammation
Chapter. 3.3. DNA methylation addiction
Chapter. 3.4. Oncoviruses
Chapter. 3.5. Sustained proliferative signaling
Chapter. 3.6. Evasion of growth suppressors
Chapter. 3.7. Replicative immortality
Chapter. 3.8. Resisting Cell death
Chapter. 3.9. Invasion and metastasis
Chapter. 3.10. Angiogenesis induction.-Chapter. 3.11. Deregulated cellular energetics/Molecular sweet tooth
Chapter. 3.12. Tumor Immune-evasion
Chapter. 3.13. Cancer stem cells and tumor cell plasticity
4. Section 4. Cancer RNome: Therapeutic implications(Translational implications of the cancer RNome). Chapter. 4.1. RNAs as diagnostic/prognostic biomarkers
Chapter. 4.2. RNAs in cancer therapy & chemo-resistance.

Summary: This book provides a concise, yet comprehensive overview of cancer risks in patients with inflammatory bowel disease (IBD), as well as the screening modalities used to reduce these risks. Each chapter presents a major malignancy that patients with IBD are at risk from, stemming from the disease itself or from the medications used to treat the disease. Malignancies covered include colorectal cancer, skin cancer, lymphoma, and other cancers. Cancer risk and screening with current and emerging drug therapies are also discussed. Written by experts in the field, Cancer Screening in Inflammatory Bowel Disease: A Guide to Risk Management and Techniques is a valuable resource for gastroenterologists, colorectal surgeons, and primary care physicians who treat and manage patients with inflammatory bowel disease.

Contents:
Epidemiology and Risk Factors for Colorectal Cancer in Inflammatory Bowel Diseases
Screening for Colon Cancer in Inflammatory Bowel Disease
Skin Cancer Risk and Screening in Patients with Inflammatory Bowel Disease
Female Specific Cancern Risks and Screening in Inflammatory Bowel Disease
Lymphoma Risk and Screening in Inflammatory Bowel Disease
Pouch Neoplasia following IPAA in Patients with Underlying Inflammatory Bowel Diseases
Other Cancers: Small Bowel Cancers, Cholangiocarcinoma, Urinary Tract, and Anal Cancer Risk and Screening in Inflammatory Bowel Disease
Cancer Risks and Screening with Current and Emerging Drug Therapies in Inflammatory Bowel Diseases
Preventing Colorectal Cancer in Patients with Inflammatory Bowel Diseases: Chemopreventive and Surgical Approaches
Cancer Risk and Screening in Pediatric Patients
Colorectal Cancer Risk and Screening in Geriatric Patients
Use of Biologic Drugs Following an Initial Diagnosis of Malignancy.

Summary: This book represents an updated summary of the state of the art of the characterization of cancer stem cell/cancer initiating cell (CSC/CIC) properties. Experts provide an overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients.

Contents:
Cancer Stem Cells: from birth to death
A Cancer Stem Cell Perspective on Minimal Residual Disease in Solid Malignancies
Cancer Stem Cells in Lung Cancer: Roots of Drug Resistance and Targets for Novel Therapeutic Strategies
Overexpression of YY1 Regulates the Resistance of Cancer Stem Cells: Targeting YY1
Cancer Stem Cell Challenges in Melanoma Characterization and Treatment
Harnessing the immune system to target cancer cells
Targeting leukemia stem cells and the immunological bone marrow microenvironment
Crosstalk Between Prostate Cancer Stem Cells and Immune Cells: Implications for Tumor Progression and Resistance to Immunotherapy
Cancer stem cells: the players of immune evasion from immunotherapy
Index.

Contents:
Oxytocin and vasopressin systems: oxytocin, vasopressin, and their interplay with gonadal steroids: essentials of cancer stem cells and conceptual modeling
Theoretical and experimental foundations of the "cancer stem cell" model
The hallmarks of prostate cancer stem cells
Self-renewal, induced proliferation, and autonomous cell growth represent distinct modes of cell multiplication: relevance to the cancer stem cell theory
Human embryonic stem cells and cancer: modeling disease in a dish
Cancer stem cell as a result of a reprogramming-like mechanism: implications in tumor development and treatment
A cancer stem cell model: an insight into the conversion of induced pluripotent stem cells to cancer stem-like cells
Altruistic stem cells and cancer stem cells
The emerging concept of EMT-induced cancer stem cells
Models to study chronic myeloid leukemia cancer stem cells
Cancer stem cells in melanoma: biomarkers and mathematical models
Stem cells in liquid tumors
Acute myeloid leukemia stem cells: updates and controversies
Leukemia-initiating cells in acute lymphoblastic leukemia
Stem cells in solid tumors
Lung cancer stem cells and resistance to radiotherapy
Prostate cancer cell heterogeneity and prostate cancer stem cells
Glioblastoma stem cells drive tumor recurrence and patient relapse: what's the evidence?
Stem cells and pancreatic cancer
Melanoma subpopulations with cancer stem cell phenotypes
Sarcoma stem cells
Cancer stem cells in tumor metastasis perspective
Cancer stem cells in metastasis and minimal residual disease
Role of cancer stem cells in metastasis
Cancer stem cells and the stromal microenvironment
A perspective on breast cancer malignant progression: from cancer stem cell intra tumor heterogeneity to metastasis-initiating cells
Novel and potential targets in cancer stem cells
Targeting cancer stem cells: modulating embryonic stem cell signaling, epigenetics, and tumor metabolism
Oct4, Oct1, and cancer stem cells
The role of Cripto-1 in cancer and cancer stem cells
Leptin signaling in the regulation of stem and cancer stem cells
Tumor-initiating stem-like cells: carcinogenesis through toll-like receptors, environmental factors, and virus
The role of epithelial cell polarity pathways on cancer stem cells
Cancer-initiating cells, exosomes, and the premetastatic niche
Microrna therapeutics to target brain tumor stem cells
The riboproteome orchestrates self-renewal and cell fate in leukemia
Clinical relevance of cancer stem cells in patients
Targeting different states of breast cancer stem cells
Difficulties in targeting the beating heart: therapeutic implications of the cancer stem cell hypothesis in melanoma
Targeting cancer stem cells for overcoming drug resistance and cancer progression
The role of cancer stem cells in tumor radioresistance.

Contents:
Evidence-based symptom management
Artharalgias and myalgias
Cancer-related fatigue
Menopausal symptoms
Pain
Sleep disturbances
Hypersensitivity reactions to antineoplastic drugs
Infection
Constipation
Diarrhea
Nausea and vomiting
Malignant ascites
Bladder disturbances
Bleeding and thrombotic complications
Dyspnea
Effusions
The cancer cachexia syndrome
Dysphagia
Mucositis
Xerostomia
Increased intracranial pressure
Peripheral neuropathy
Alopecia
Altered body image and sexual health
Extravasation
Lymphedema
Ocular and otic complications
Skin and nail bed changes
Anxiety
Cognitive dysfunction
Depression
Grief
Spiritual distress
Symptoms when death is imminent.

Contents:
I: In vitro diagnostics. Cancer theranostics: an introduction
Genomics-based cancer theranostics
Proteomics-based theranostics
II: Molecular imaging. Radionuclide imaging of cancer therapy
Near-infrared fluorescence imaging probes for cancer diagnosis and treatment
Bioluminescence imaging of cancer therapy
Magnetic resonance imaging of cancer therapy
Ultrasound imaging of cancer therapy
Photoacoustic imaging for cancer diagnosis and therapy guidance
III: Imaging-guided therapy. Multimodality image-guided lung intervention systems
Label-free molecular vibrational imaging for cancer diagnosis
Multimodality image-guided treatment
Medical robotics for cellular and molecular imaging
IV: Theranostic platforms. Porphyrins for imaging, photodynamic therapy, and photothermal therapy
Magnetic resonance imaging and alternating magnetic fields
Ultrasound for drug/gene delivery
Radionuclides for imaging and therapy in oncology
Noble metal nanoparticle platform
Cancer theranostics with carbon-based nanoplatforms
Silica nanoparticle platform
Quantum dots for traceable therapeutic delivery
Polymer- and protein-based nanotechnologies for cancer theranostics
V: Other. Clinical translation and regulations of theranostics
Scale-up production of theranostic nanoparticles
Market considerations for nanomedicines and theranostic nanomedicines
Application of theranostics to measure and treat cell heterogeneity in cancer.

Contents:
Section I. Clinical
Section II. Laboratory models
Section III. Strategies to protect the ovary.

Contents:
New approaches in immunotherapy for the treatment of lung cancer
Novel approaches for vaccination against HPV-induced cancers
Tapping the potential of DNA delivery with electroporation for cancer immunotherapy
Targeted immunotherapy designed to treat MUC1-expressing solid tumour
Chimeric DNA vaccines: an effective way to overcome immune tolerance
Linked CD4 T cell help: broadening immune attack against cancer by vaccination
mRNA cancer vaccines, messages that prevail
The use of Anti-CD40 mAb in cancer
Index.

Contents:
Single Step Antigen Loading and Maturation of Dendritic Cells Through mRNA Electroporation of a Tumor-Associated Antigen and a TriMix of Costimulatory Molecules
Generation of Multiple Peptide Cocktail-Pulsed Dendritic Cells as a Cancer Vaccine
Pulsing Dendritic Cells with Whole Tumor Cell Lysates
Antigen Trapping by Dendritic Cells for Anti-Tumor Therapy
Ex Vivo Loading of Autologous Dendritic Cells with Tumor Antigens
Tumor Antigen/Cytokine-Pulsed Dendritic Cells in Therapy Against Lymphoma
Dendritic Cells Primed with Protein-Protein Fusion Adjuvant
Antigen-Specific mRNA Transfection of Autologous Dendritic Cells
Electroporation of Dendritic Cells with Autologous Total RNA from Tumor Material
Dendritic Cells Transfected with Adenoviral Vectors as Vaccines
Genetic Modification of Dendritic Cells with RNAi
Fast Monocyte-Derived Dendritic Cells-Based Immunotherapy
Intratumoral Injection of BCG-CWS Pretreated Dendritic Cells Following Tumor Cryoablation
Exploiting the CD1d-iNKT Cell Axis for Potentiation of DC-Based Cancer Vaccines
Modification of T Lymphocytes to Express Tumor Antigens
Genetic Modification of Mouse Effector and Helper T Lymphocytes Expressing a Chimeric Antigen Receptor
Genetic Modification of Cytotoxic T Lymphocytes to Express Cytokine Receptors
Monitoring the Frequency and Function of Regulatory T Cells and Summary of the Approaches Currently Used to Inhibit Regulatory T Cells in Cancer Patients
Cytokine Activation of Natural Killer Cells
Loading of Acute Myeloid Leukemia Cells with Poly(I:C) by Electroporation
Autologous Tumor Cells Engineered to Express Bacterial Antigens
Tumor Cell Transformation Using Antisense Oligonucleotide
The Direct Display of Costimulatory Proteins on Tumor Cells as a Means of Vaccination for Cancer Immunotherapy
Cloning Variable Region Genes of Clonal Lymphoma Immunoglobulin for Generating Patient-Specific Idiotype DNA Vaccine
Heat Shock Proteins Purified from Autologous Tumors Using Antibody-Based Affinity Chromatography
Invariant Chain-Peptide Fusion Vaccine Using HER-2/neu
TLR-9 Agonist Immunostimulatory Sequence Adjuvants Linked to Cancer Antigens
Production of Multiple CTL Epitopes from Multiple Tumor-Associated Antigens
Preparation of Polypeptides Comprising Multiple TAA Peptides
Idiotype Vaccine Production Using Hybridoma Technology
Preparation of Cancer-Related Peptide Cocktails that Target Heterogeneously-Expressed Antigens
Making an Avipoxvirus Encoding a Tumor-Associated Antigen and a Costimulatory Molecule
Bacterial Vectors for the Delivery of Tumor Antigens
Preparation of Peptide Microspheres Using Tumor Antigen-Derived Peptides
Production of Antigen-Loaded Biodegradable Nanoparticles and Uptake by Dendritic Cells
Development of Plasmid-Lipid Complexes for Direct Intratumoral Injection
The Use of Dendritic Cells for Peptide-Based Vaccination in Cancer Immunotherapy
Advances in Host and Vector Development for the Production of Plasmid DNA Vaccines
Challenges Facing the Development of Cancer Vaccines
Future of Cancer Vaccines.

Summary: Recounts the author's experience as a cancer patient. He was diagnosed with stage 2A Hodgkin lymphoma at age 30, and was cancer free in 2010, and five years later considered in complete remission.

Contents:
Molecular biology of cancer and aging
Caring for geriatric cancer patients : the concept of pawspice and what is needed aside from medical care
The warning signs of cancer in geriatric pets
Basic types of cancer and their biological behavior
Generating the diagnosis and prognosis of cancer in geriatric pets
Treating cancer in geriatric pets
Principles and philosophic perspective
The role of surgery in cancer management
Chemotherapy in the management of geriatric cancer
Adverse effects of cancer therapy in geriatric pets
The role of radiation therapy in cancer management
Immunotherapy, cancer vaccines, and gene therapy
Chemoprevention and immunonutrition
Integrative and alternative medicine
Electroporation and electrochemotherapy
Pain control for the geriatric cancer patient
Decision making with advanced and recurrent cancer in the geriatric patient
When and how to decide that a geriatric cancer patient is terminal
Palliative care : end of life 'pawspice' care
Euthanasia for the geriatric cancer patient
The veterinary professional/client relationship : supporting your clients supporting yourselves
Professional support : the wellbeing of the veterinarian and the team.

Contents:
Basic principles in the diagnosis and management of small animal infection
Laboratory diagnosis of canine and feline infectious diseases
Isolation in cell culture
Immunoassays
Isolation and identification of aerobic and anaerobic bacteria
Isolation and identification of fungi
Nucleic acid detection assays
Antiinfective therapy
Principles of antiinfective therapy
Antiviral and immunomodulatory drugs
Antibacterial drugs
Antifungal drugs
Antiprotozoal drugs
Basic principles for infection control
Infection control programs for dogs and cats
Immunization
Major infectious diseases and their etiologic agents
Viral diseases
Rabies
Canine parvovirus infections and other viral enteritides
Canine distemper virus infection
Canine herpesvirus infection
Canine viral respiratory infections
Infectious canine hepatitis
Feline panleukopenia virus infection and other viral enteritides
Feline coronavirus infection
Feline immunodeficiency virus infection
Feline leukemia virus infection
Feline respiratory viral infections
Feline poxvirus infections
Pseudorabies
Viral papillomatosis
Vector-borne and other viral encephalitides
Bacterial diseases
Ehrlichiosis
Anaplasmosis
Rocky mountain spotted fever
Salmon poisoning disease
Coxiellosis and q fever
Chlamydial infections
Streptococcal and enterococcal infections
Staphylococcus infections
Gram-negative bacterial infections
Anaerobic bacterial infections
Bordetellosis
Cell wall-deficient bacterial infections
Mycoplasma infections
Hemoplasma infections
Actinomycosis
Nocardiosis
Mycobacterial infections
Salmonellosis
Enteric Escherichia coli infections
Campylobacteriosis
Enteric clostridial infections
Gastric Helicobacter-like infections
Leptospirosis
Lyme borreliosis
Bartonellosis
Canine brucellosis
Tetanus and botulism
Yersinia pestis (plague) and other yersinioses
Tularemia
Bite and scratch wound infections
Fungal and algal diseases
Dermatophytosis
Malassezia infections
Blastomycosis
Histoplasmosis
Cryptococcosis
Coccidioidomycosis
Sporotrichosis
Aspergillosis
Rhinosporidiosis
Candidiasis
Miscellaneous fungal diseases
Pythiosis, lagenidiosis, and zygomycosis
Protothecosis
Pneumocystosis
Protozoal diseases
Toxoplasmosis
Neosporosis
Leishmaniosis
Babesiosis
Cytauxzoonosis
Canine and feline hepatozoonosis
Trypanosomiasis
Giardiasis
Trichomoniasis
Cryptosporidiosis
Isosporiasis
Miscellaneous protozoal diseases
Infections of selected organ systems
Pyoderma, otitis externa, and otitis media
Osteomyelitis, discospondylitis, and infectious arthritis
Infections of the cardiovascular system
Bacterial bronchopneumonia and pyothorax
Intra-abdominal infections
Bacterial infections of the genitourinary tract
Bacterial meningitis
Vaccination schedules for dogs and cats.

Summary: This book discusses canine and feline skin cytology and the importance of this diagnostic tool in interpreting skin lesions. With more than 600 clinical and cytological color pictures, it explains the cytological patterns observed in all cutaneous inflammatory and neoplastic lesions in cats and dogs, as well as cutaneous metastasis of non-primary skin neoplasms. The first part of the book describes cell morphology and cytological patterns, providing an overview of the normal structure of the skin. In the second chapter, readers learn how to choose the best techniques for different types of lesions. Further chapters present the cytological findings in the main inflammatory and neoplastic skin diseases. By focusing on the macroscopic aspects of the lesions from which the cells are collected, it helps readers to interpret cytological specimens. The final chapter explores the cytology of cutaneous metastasis from internal organs or accessory glands. This book offers veterinary students and practitioners alike an essential diagnostic tool.

Contents:
1. Morphology and Function of Skin Cells
2. Techniques of Sampling, Preparation and Staining of Cytological Specimens
3. Cytology of Canine and Feline Non Neoplastic Skin Diseases
4. Cytology of Skin Tumors
5. Cutaneous Metastasis from Non Primary Skin Tumors.

Contents:
Looking ahead after 50 years of research on cannabinoids / Raphael Mechoulam
Cannabinoid receptor intracellular signaling : the long journey from binding sites to biological effects / Lawrence C. Blume, Khalil M. Eldeeb, and Allyn C. Howlett
Endocannabinoid biochemistry : what do we know after 50 years? / Filomena Fezza and Mauro Maccarrone
Genetic dissection of the endocannabinoid system and how it changed our knowledge of cannabinoid pharmacology and mammalian physiology / Beat Lutz
Cannabinoids, endocannabinoids, and stress / Cecilia J. Hillard, Qing-song Liu, XiaoQian Liu, Bin Pan, Christopher J. Roberts, and Leyu Shi
Cannabinoids and the brain : new hopes for new therapies / Javier Fernández-Ruiz, Mariluz Hernández, and Yolanda García-Movellán
Potential therapeutic applications of cannabinoids in gastrointestinal and liver diseases : focus on tetrahydrocannabinol pharmacology / Paolo Caraceni, Francesca Borrelli, Ferdinando A. Giannone, and Angelo A. Izzo
Years of cannabinoid research and the need for a new nomenclature / Vincenzo Di Marzo and Luciano De Petrocellis.

Summary: This volume highlights the recent advances in the understanding of the endocannabinoid system and the likely benefit from the therapeutic effects of cannabinoid treatment in a variety of health issues. Archeological evidence has shown that Cannabis has a long history of use for multiple purposes, including the treatment of medical conditions. The primary active constituent of the hemp plant Cannabis sativa, delta 9-tetrahydrocannabinol (Δ9-THC), causes euphoria, enhancement of sensory perception, tachycardia, antinociception, difficulties in concentration and impairment of memory, among other effects. Despite these undesirable effects, signaling is mostly inhibitory and suggests a putative role for cannabinoids as therapeutic agents by managing several diseases where inhibition of neurotransmitter release would be beneficial. The themes of this book have been edited and written by world-leaders in the field, The contents of the volume aims at readers from a range of academic and professional disciplines, such as biomedicine, several areas of biology, neurology, clinical medicine and pharmacy.

Contents:
Chapter 2: Neuromolecular Mechanisms of Cannabis Action
2.1 Introduction and Scope of this Chapter
2.1.1 Neuromolecular Targets of THC: The Cannabinoid Receptors
2.1.1.1 CB1 Cannabinoid Receptor Characterisation: Protein, Distribution, Signalling and Pharmacology
2.1.1.2 CB2 Cannabinoid Receptor Characterisation: Protein, Distribution, Signalling and Pharmacology
2.1.2 Neuromolecular Targets of THC: Beyond the Cannabinoid Receptors
2.1.3 Neuromolecular Targets of CBD
2.1.4 Neuromolecular Targets of Other Cannabinoids
2.1.4.1 Delta9-Tetrahydrocannabidivarin 2.1.4.2 Cannabinol
2.1.4.3 Delta9-Tetrahydrocannabinolic Acid
2.1.4.4 Cannabidivarin
2.1.4.5 Cannabidiolic Acid
2.1.4.6 Cannabigerol
2.1.4.7 Cannabichromene
2.1.5 Concluding Remarks
References
Chapter 3: Neuropharmacological Effects of the Main Phytocannabinoids: A Narrative Review
3.1 Introduction
3.2 Neuromolecular mechanisms of action of the main phytocannabinoids
3.2.1 THC
3.2.2 CBD
3.2.3 Delta-9-THCV
3.2.4 Delta-9-THCA
3.2.5 Delta-8-THC
3.2.6 CBDV
3.2.7 CBN
3.2.8 CBG
3.2.9 CBC
3.2.10 CBDA 3.3 Neurochemical and behavioral effects of THC and CBD: Human studies
3.3.1 THC
3.3.2 CBD
3.4 Approved indications of cannabis-based products, THC and CBD
3.4.1 Cannabis-based products
3.4.2 THC
3.4.2.1 Nausea and vomiting due to chemotherapy
3.4.2.2 Appetite and decreasing weight loss associated with HIV/AIDS
3.4.2.3 Multiple sclerosis symptoms (spasticity and chronic pain)
3.4.2.4 Chronic pain (neuropathic and cancer pain)
3.4.3 CBD
3.4.3.1 Antiepileptic
3.4.3.2 Therapeutic potentials of CBD with moderate/modest evidence from RCTs 3.5 Adverse effects of THC and CBD
3.5.1 Cannabis-based products and THC
3.5.2 CBD
3.6 Conclusions
References
Chapter 4: Emerging Roles of Cannabinoids and Synthetic Cannabinoids in Clinical Experimental Models
4.1 Introduction
4.1.1 Cannabinoid Classifications
4.2 Endocannabinoids
4.3 Phytocannabinoids
4.4 Synthetic Cannabinoids
4.5 Cannabinoids in Neuromodulation
4.5.1 Cannabinoids in Epilepsy
4.5.2 Cannabinoids in Alzheimerś Disease
4.5.3 Cannabinoids in Parkinsonś Disease
4.6 Cannabinoids in Cancer
4.7 Cannabinoids in Metabolic Disorders

Summary: This book presents a well-balanced view of the potential medical use of cannabinoids in pain. It comprehensively covers the current challenges with medical cannabis utilization and provides recommendations for research and future directions. Organized into nine sections, the book begins with an introduction to medical cannabis, including its history, regulations, and the general attitudes of pain physicians on cannabis. Section two explores the biological effects of marijuana via the endocannabinoid system and its complex structure of receptors and enzymes. Sections three, four, and five then delve further into pharmacology and the mechanisms of action applicable to cannabinoids in managing pain. Timely and socially conscious, section six examines the benefits of substituting opioids with cannabinoids for preoperative management. Echoing the book's well-rounded content, sections seven and eight consider the challenges with medical cannabis, including safety and quality control, brain development risks, vaping hazards, and withdrawal. The book then closes with a look at the future of cannabis in medical research. Thoroughly and equitably composed, Cannabinoids and Pain is an invaluable resource for primary care physicians, pain and palliative care physicians, and oncologists.

Contents:
History of Cannabis
Cannabis Regulations
The demand for medical cannabis education
Pain physicians and cannabis: attitudes and beliefs
Cannabis Terminology
THE ENDOCANNABINOID SYSTEM
The CB1 Receptors
The CB2 Receptors
Endocannabinoids: Anandamide and 2-AG
Phytocannabinoids:Tetrahydrocannabinol (THC)
Phytocannabinoids: Cannabidiol (CBD)
Other Phytocannabinoids
Cannabinoids Drug interaction
Dronabinol (Marinol)
Nabilone (Cesamet)
Cannabidiol (Epidiolex)
Nabiximols (Sativex)
Medical Cannabis Strains
The model of a specialized cannabis clinic
Barriers for the prescription of cannabis-based medicines
Practical recommendations for the use of medical cannabis
Medical Cannabis Dosing and Titration
Patient safety considerations
Cannabinoids and Pain: Mechanisms of action
Cannabinoids and Pain: Clinical Evidence
Cannabinoids and Cancer Pain
Cannabinoids as a substitute for opioids: Basic science and Clinical evidence
Cannabiinoids as a substitute for opioids: Suggested algorithm
Perioperative management of patients on cannabinoids
The Colorado Experience
Product Safety and Quality control
Cannabis and brain development
Cannabis and mental health risks
Cannabis and adolescents
Cannabis and child development during and after pregnancy
Cannabis impairment and Adverse events
Vaping hazards
Cannabis Use Disorder
Cannabis withdrawal
Future research.

Summary: Research on cannabis and sleep is emerging with promising results. This book offers current and comprehensive knowledge on cannabinoid research results in connection with sleep. The volume covers aspects of the hemp plant Cannabis sativa, the pharmacology of cannabinoids, neurobiology and pharmacology of sleep and wakefulness, and the benefits and side effects of cannabis on the central nervous system. It further discusses the putative therapeutical properties of cannabinoids and endocannabinoids and their potential for the treatment of sleep disorders such as insomnia, obstructive sleep apnea, REM sleep behavior disorder, and restless legs syndrome. The book is written by medical and scientific experts in this field and intended for researchers from a range of disciplines such as biomedicine, biology, neurosciences, clinical medicine, neurology, and pharmacology.

Contents:
Constituents of Cannabis Sativa
Synthetic and Natural Derivatives of Cannabidiol
Clinical Pharmacokinetics of Cannabinoids and Potential Drug-Drug Interactions
Cannabinoid Receptors and Ligands: Lessions from CNS Disorders and the Quest for Novel Treatment Venues
Sleep-Wake Neurobiology
Cannabinoids and Sleep/Wake Control
Effects of Cannabinoid Agonists and Antagonists on Sleep in Laboratory Animals
Modulation of Noradrenergic and Serotonergic Systems by Cannabinoids: Electrophysiological, Neurochemical and Behavioral Evidence
Natural Cannabinoids as Templates for Sleep Disturbances Treatment
The Effect of Cannabinoids on the Brain´s Circadian Clock
Effects of Cannabis Consumption on Sleep
Addiction and Sleep Disorders
Cannabis for Restless Legs Syndrome.

Contents:
Contributors
Preface
Mouse Neuroblastoma CB1 Cannabinoid Receptor-Stimulated [35S]GTPgammaS Binding: Total and Antibody-Targeted Galpha Protein-Specific Scintillation Proximity Asays / by Khalil Eldeeb, Sandra Leone-Kabler, Allyn C. Howlett
Protocols and Good Operating Practices in the Study of Cannabinoid Receptors / by Linda M. Console-Bram, Pingwei Zhao, Mary E. Abood
Real-Time Measurement of Cannabinoid Receptor-Mediated cAMP Signaling / by Morag R. Hunter, David B. Finlay, Christa E. Macdonald, Erin E. Cawston, Natasha L. Grimsey, Michelle Glass
Techniques for the Cellular and Subcellular Localization of Endocannabinoid Receptors and Enzymes in the Mammalian Brain / by Luigia Cristino, Roberta Imperatore, Vincenzo Di Marzo
Endocannabinoid Transport Proteins: Discovery of Tools to Study Sterol Carrier Protein-2 / by Cecilia J. Hillard, Huan Huang, Caleb D. Vogt, Beatriz E. Rodrigues, Terrence S. Neumann, Daniel S. Sem, Friedhelm Schroeder, Christopher W. Cunningham
Lipidomics: A Corrective Lens for Enzyme Myopia / by Heather B. Bradshaw, Emma Leishman
Functional Analysis of Mitochondrial CB1 Cannabinoid Receptors (mtCB1) in the Brain / by Su Melser, Antonio C. Pagano Zottola, Roman Serrat, Nagore Puente, Pedro Grandes, Giovanni Marsicano, Etienne Hebert-Chatelain
Modeling Neurodegenerative Disorders for Developing Cannabinoid-Based Neuroprotective Therapies / by Javier Fernández-Ruiz, María Gómez-Ruiz, Concepción García, Mariluz Hernández, José A. Ramos
Metabolic Profiling of CB1 Neutral Antagonists / by Herbert H. Seltzman, Rangan Maitra, Katharine Bortoff, Jay Henson, Patricia H. Reggio, Daniel Wesley, Joseph Tam
Ligand-Assisted Protein Structure (LAPS): An Experimental Paradigm for Characterizing Cannabinoid-Receptor Ligand-Binding Domains / by David R. Janero, Anisha Korde, Alexandros Makriyannis
New Methods for the Synthesis of Cannabidiol Derivatives / by Ana Lago-Fernandez, Vanessa Redondo, Laura Hernandez-Folgado, Laura Figuerola-Asencio, Nadine Jagerovic
Approaches to Assess Biased Signaling at the CB1R Receptor / by Robert B. Laprairie, Edward L. Stahl, Laura M. Bohn
Design and Synthesis of Cannabinoid 1 Receptor (CB1R) Allosteric Modulators: Drug Discovery Applications / by Abhijit R. Kulkarni, Sumanta Garai, David R. Janero, Ganesh A. Thakur
Assessing Allosteric Modulation of CB1 at the Receptor and Cellular Levels / by Caitlin E. Scott, Debra A. Kendall
Purification of Functional CB1 and Analysis by Site-Directed Fluorescence Labeling Methods / by Jonathan F. Fay, David L. Farrens
Mass Spectrometry Analysis of Human CB2 Cannabinoid Receptor and Its Associated Proteins / by Zhao-Hui Song, Alyssa S. Laun, Jian Cai
Expression and NMR Structural Studies of Isotopically Labeled Cannabinoid Receptor Type II / by Alexei Yeliseev, Klaus Gawrisch
Methods for the Development of In Silico GPCR Models / by Paula Morales, Dow P. Hurst, Patricia H. Reggio
Molecular Dynamics Methodologies for Probing Cannabinoid Ligand/Receptor Interaction / by Diane L. Lynch, Dow P. Hurst, Derek M. Shore, Mike C. Pitman, Patricia H. Reggio
Author Index
Subject Index.

Summary: Offers a guide addressing nursing skills and responsibilities in cannabis care, including the physiology of the human endocannabinoid system, cannabis care as it relates to specific disease processes, the history of cannabis, advocacy and ethics, and the ins and outs of cannabis dosing, delivery methods, side effects, and more. Essential for all practice areas, this is a foundational resource for both students and practicing nurses who want to provide knowledgeable and effective medical cannabis care. --From publisher description.

Contents:
History of cannabis and prohibition / Llewellyn Dawn Smith
The human endocannabinoid system (ECS): physiology / Denise A. Foster
Cannabis pharmacology: from the whole plant to pharmaceutical applications / Rachel A. Parmelee, Carey S. Clark, and Deanna M. Sommers
Cannabidiol / Eileen Konieczny
Cannabis sciences: reviewing trends / Carey S. Clark, Rachel A. Parmelee, Barbara J. Ochester
The nurse's role: providing cannabis care / Carey S. Clark
Advanced practice nursing considerations / Eloise Theisen
Legal, ethical, and advocacy concerns: cannabis from the federal to state level / Carey S. Clark.

Summary: The use of cannabinoid-based medicines (CBM), and cannabis in particular, has risen steadily among cancer and palliative care patients over the last few years. This textbook aims to address the multiple challenges facing healthcare providers regarding the use of CBM in this vulnerable patient population. It provides insight into the latest preclinical and clinical data and offers a practical approach on the use of CBM in a rapidly evolving landscape. It answers questions regarding the prescribing process and elucidates controversies regarding cannabis disease-modifying effects. The first chapters will review basic concepts of the endocannabinoid system and pharmacology of CBM, while focusing more specifically on the unique characteristics of two main cannabinoids: THC and CBD. Indicating which benefits can be expected from using either or both of these compounds, the book then addresses issues of drug-drug interactions and other challenges involved in prescribing CBM to frail patients with polypharmacy and multiple comorbidities. Comparing available products, both approved and non-approved by the FDA, the book discusses regional challenges for accessing reliably tested and labelled products in the context of standardization efforts. After carefully determining objectives and addressing patient expectations, further chapters will examine the different clinical settings in which CBM may be useful in cancer care and explore symptom management, including cancer pain, anxiety, nausea, and insomnia among others. The possible benefits of cannabis psychoactivity will also be discussed, including harm reduction strategies for patients who wish to explore these effects. Cannabis and Cannabinoid-Based Medicines in Cancer Care: A Comprehensive Guide to Medical Management serves as a comprehensive text for oncologists, palliative care specialists, general practitioners, and nurse practitioners working with cancer patients or in palliative care settings.

Contents:
Overview of the Endocannabinoid System and Endocannabinoidome
Cannabinoid-Based Medicine: Pharmacology and Drug Interactions
Future Therapeutic Potential of Synthetic Cannabinoids and Endocannabinoid System Modulators
Cannabis-Based Medicines as Anti-Cancer Agents
Cannabinoid-Based Medicines and Cancer Symptom Management
Patient Evaluation: Precautions and Managing Expectations
Choosing a Product, Route of Administration, Initial Dosage, Titration, Monitoring and Management of Adverse Effects
Psychoactive Effects of Cannabinoid-Based Medicines: Exploration and Inquiry.

Summary: Legalization of marijuana is becoming increasingly prominent in the United States and around the world. While there is some discussion of the relationship between marijuana and overall health, a comprehensive resource that outlines the medical literature for several organ systems, as well as non-medical societal effects, has yet to be seen. While all physicians strive to practice evidence-based medicine, many clinicians aren't aware of the facts surrounding cannabis and are guided by public opinion. This first of its kind book is a comprehensive compilation of multiple facets of cannabis recommendation, use and effects from a variety of different perspectives. Comprised of chapters dedicated to separate fields of medicine, this evidence-based guide outlines the current data, or lack thereof, as well as the need for further study. The book begins with a general overview of the neurobiology and pharmacology of THC and hemp. It then delves into various medical concerns that plague specific disciplines of medicine such as psychiatry, cardiology, gastrointestinal and neurology, among others. The end of the book focuses on non-medical concerns such as public health and safety, driving impairment and legal implications. Comprised of case studies and meta-analyses, Cannabinoids in Medicine: An Evidence-Based Approach provides clinicians with with a concise, evidence-based guide to various health concerns related to the use of marijuana. By addressing non-medical concerns, this book is also a useful resource for professionals working in the public health and legal fields.

Contents:
Intro
Foreword
Losing Ground: The Rise of Cannabis Culture
Addressing the Wider Implications of Increasing Marijuana Use
Why Our Knowledge of the Risks in Cannabis Exposure Has Increased
Limitations to Our Knowledge: Inadequate Measures, No Real Baseline
Current Measurements of Marijuana Use Showing the Comparative Scope of the Problem
Marijuana Use in Sub-populations at High Risk
Monitoring the Future School-Based Data
Widening Societal Impact of Increased Marijuana Prevalence The Societal Impact of Expanded Cannabis Extends to the Use of Other Substances Of Abuse
Final Thoughts on the Wider Implications of Increased Use
Reference Section
Contents
Contributors
Part I: Basic Science
Chapter 1: The Properties and Use of Cannabis sativa Herb and Extracts
Background
THC
Methods of Use
Metabolism
Synthetic Cannabinoids and Cannabimimetics
Hemp
CBD
Conversion to THC
CBD as a Quality Medicine
Discussion
Summary
References
Chapter 2: Cannabinoid and Marijuana Neurobiology
Introduction Discovery, Evolutionary Origins, and Function of the Endocannabinoid System
Endocannabinoid System in the Brain
Endocannabinoid System Function in Early and Adolescent Brain Development
Overall Function of the Endocannabinoid System in the Brain [45]
Endocannabinoid System in Peripheral Tissues
Disturbances of the Endocannabinoid System in the Brain
Marijuana and the Brain: Receptors and Changes in Endocannabinoid Signaling
Conclusion
References
Chapter 3: The Pharmacodynamics, Pharmacokinetics, and Potential Drug Interactions of Cannabinoids Drug-Drug Interaction with Cannabinoids
Pharmacokinetics/Pharmacodynamics of Cannabinoids
Pharmacodynamics
Pharmacokinetics
Drug-Drug Interactions
Phase I Metabolism (Cytochrome P450)
Phase II Metabolism
Transport Proteins
Epidiolex® Drug-Drug Interactions
THC Drug-Drug Interactions
Conclusion
References
Part II: Clinical Evidence
Chapter 4: Cannabis and Neuropsychiatric Effects
Blunted: The Effects of Cannabis on Cognition and Motivation
Memory
Attention
Executive Function
Intelligence and IQ
Motivation
Mechanisms of Action Moderating Factors
Summary and Future Directions
Cannabis and Psychiatric Conditions
Psychosis
Depression and Anxiety
Addiction
Cannabis-Related Violence and Death
Potential Psychiatric Benefits of CBD
Conclusion
Cannabis Use and Psychosis, Mood, and Anxiety Disorders
Introduction
Increasing Cannabis Potency Post-legalization
Post-legalization Trends in the Prevalence and Frequency of Cannabis Use
Impact of Medical Legalization
What Does Research Tell Us About Cannabis Use and Mental Illness?
Cannabis, Psychosis, and Schizophrenia

Summary: This book educates and familiarizes psychiatrists with the impact of cannabis beyond the scope of addiction and ways to effectively discuss the existing literature and knowledge with patients. Cannabis in Psychiatric Practice is organized by clinical setting to help tailor the literature to psychiatrists and other mental health clinicians working in all areas, whether traditional outpatient clinics, emergency departments, inpatient psychiatry or medical units. It helps readers, regardless of their training background, learn about the impact of cannabis on a variety of disorders in a manner adjusted to the unique needs and challenges of their particular treatment settings and patient populations. The book also includes clinical cases and practical tips integrating the current evidence, treatment approaches, and psychoeducation needed to effectively practice in the era of modern-day psychiatry and cannabis legalization. Chapters are written in a clear, easy-to-read style, allowing readers to reference specific portions of the book as needed, increasing its utility for the general psychiatrist and mental health clinician. With the increasing prevalence and availability of cannabis and CBD products, this book is an invaluable reference for psychiatrists who wish to explore the impact of cannabis in their clinical practice.

Contents:
1. Public Health Concerns of Cannabis
2. Clinical Pharmacology of Cannabinoids
3. Cannabidiol: Overview, Complexities and Opportunities for Behavioral Health
4. Developmental Impact
5. Cannabis in the Child and Adolescent Outpatient Mental Health Setting
6. Cannabis in The Child and Adolescent Emergency and Inpatient Psychiatric Settings
7. Clinical Considerations for Cannabis in the Child and Adolescent Consultation-Liaison Setting
8. Disease course & prognosis
9. Evaluation of Co-occurring Psychiatric Disorders and Cannabis Use in the Outpatient Setting
10. Treatment of Co-occurring Psychiatric Disorders and Cannabis Use in the Outpatient Setting
11. Acute intoxication and agitation/violence
12. Cannabis and Psychosis
13. Self-Harm and Cannabis Use
14. Cannabis in the Adult Medical and Consultation-Liaison Settings
15. Cannabis in the Perinatal Period
16. Cannabis in the Geriatric Population
17. Marijuana Use in Organ Transplantation.

Summary: This book examines the effectiveness of a unique area of patient care, cannabis use in medicine. While many American states have legalized medical marijuana, the FDA still has not approved it as a treatment due to a lack of studies to prove its validity. Countries such as Canada and Uruguay, on the other hand, have legalized cannabis. This book aids in accelerating the medical legitimacy of cannabis through comprehensive coverage of its uses, legality, pharmacology, and potential issues. Organized into three parts, the book begins with topics that function as an introduction to cannabis for medical use, such as patient assessments, the role of genetics, evidence-based therapy reviews, legal aspects, and pharmacology. Subsequent chapters then delve into the practical applications of medical cannabis use, including treatment for gastrointestinal disorders, neurological diseases, rheumatic diseases, and pain management. The book's final section features crucial discussions on the potential complications and adverse events in cannabis use, as well as occupation and pediatric considerations. Nuanced and timely, Cannabis Use in Medicine, is a vital resource for medical practitioners of all specialties looking to add cannabis to their repertoire of therapies.

Contents:
Part I Introduction and Background to Cannabis Use in Medicine
Introduction to Cannabis for Medical Use
Legal Aspects of Cannabis
Pharmacology of Cannabis
Patient Assessment and Dosing Recommendations for Cannabis
Analytical Testing of Cannabis
The Role of Genetics in the Use of Cannabis
Evidence Based Reviews on Cannabis Therapy
Part II Use of Cannabis in the Management of Specific Medical Conditions
The Effects and Benefits of Cannabis on the Gastrointestinal Disorders
Neurological Diseases and Cannabinoid Treatment
Cannabinoid Treatment for Rheumatic Disease
The Use of Cannabis for Pain Management
Complications and Adverse Events from Cannabis Use
Part III Cannabis Use in Specific Populations
Occupational Considerations Related to Cannabis Use
Pediatric Considerations when Prescribing Cannabis
Cannabis Use in the Pregnant Patient.

Summary: Since its inception 14 years ago, CAPRISA has conducted numerous clinical studies that have influenced international TB-HIV treatment guidelines as well as HIV prevention through innovations in the microbicide and vaccine fields. This book provides a historical account of how each of CAPRISA?s high impact studies was created, developed, implemented, analysed and communicated. In doing so, the reader is taken on a journey that provides glimpses into the genesis of research ideas and how this ultimately leads to a range of HIV prevention and treatment studies that have impacted the global response to the HIV and TB epidemics. Comprised of 5 sections, the book details the following: HIV epidemic in South Africa and the establishment of a research centre to undertake clinical, epidemiological and laboratory research on HIV. CAPRISA?s clinical trials on HIV and HSV-2 prevention. These studies investigated the impact of tenofovir gel as topical antiretroviral pre-exposure prophylaxis (PrEP), implementation of topical PrEP through family planning clinics, conditional cash incentives for HIV prevention, HIV vaccines, and passive immunisation with broadly neutralising antibodies. CAPRISA?s research on the treatment of HIV and TB co-infection. A review of the major scientific findings from the CAPRISA studies on acute infection and genital mucosal immunology. Essential support activities for the conduct of clinical trials, including research laboratories and pharmacies, as well as establishing effective communication and sustainable structures for community engagement to maintain effective and respectful partnerships with participating communities. The book concludes with a chapter about the challenges facing future HIV prevention and treatment trials. The CAPRISA Clinical Trials: HIV Treatment and Prevention is a resource for undergraduate and postgraduate students, health care providers, doctors, decision-makers and researchers who are seeking guidance and insights on clinical trials? their creation, conduct and impact.

Contents:
Part I. Introduction
Studies Linked to the Evolving HIV Epidemic in South Africa: Informing the CAPRISA Scientific Agenda
CAPRISA: Establishing A Research Center to Undertake HIV Clinical Trials
Overview of Clinical Trials
Part II. CAPRISA Clinical Trials for HIV and HSV-2 Prevention
Antiretrovirals for HIV Prevention
Rolling out of tenofovir gel in family planning clinics: the CAPRISA 008 implementation trial
Conditional cash transfers to reduce HIV risk in young women: the CAPRISA 007 cluster randomised control trial
HIV vaccine and passive immunity trials
Part III: CAPRISA Clinical Trials for HIV?TB Treatment
CAPRISA 003: Timing of antiretroviral initiation in HIV-TB co-infected patients
The SAPiT Trial
Scaling up TB-HIV integration in public health clinics: translating research findings into practice
Part IV: Experiences and lessons learnt from clinical trials in CAPRISA
Lessons from the Acute Infection Study: from Bench to Bedside
Understanding sexual HIV transmission in women by focusing on the genital mucosa
Part V: Essential support activities for the conduct of clinical trials
Good practices in conducting clinical trials: Good Participatory Practice, Good Pharmacy Practice and Good Laboratory Practice
Grants Management
Taking science to the people: communication and media strategies for clinical trials
Looking ahead: What Does the Future Hold for CAPRISA?
Appendix
Index.

Summary: This volume provides an up-to-date account of the achievements pertaining to the application of capsaicin and capsaicin-like molecules in the therapy of various human ailments such as pain, non-allergic rhinitis, obesity, tumors, and gastrointestinal, dermatologic, and urologic disorders. It discusses the basic functions of the capsaicin receptor (TRPV1), its mechanisms of action, and its role in physiological and pathological processes. The text focuses on the most recent progress in the use of capsaicin and capsaicin-like molecules as a therapeutic agent and highlights potential pharmaceutical implications of further TRPV1 research. The chapters are written by noted experts in their fields of endeavor. This book offers both clinicians and researchers valuable resource and reference material on the subject that will stimulate future research.

Contents:
Capsaicin and Sensory Neurones: a Historical Perspective
Pharmacology of the Capsaicin Receptor, Transient Receptor Potential Vanilloid Type 1 Ion Channel
TRPV1 in the Central Nervous System: Synaptic Plasticity, Function and Pharmacological Implications
Topical Capsaicin Formulations in the Management of Neuropathic Pain
Capsaicin-Based Therapies for Pain Control
Intranasal Capsaicin in Management of Non-allergic (Vasomotor) Rhinitis
Capsaicin as an Anti-obesity Drug
The Potential Antitumour Effects of Capsaicin
Capsaicin as New Orally Applicable Gastroprotective and Therapeutic Drug Alone or in Combination with Non-Steroidal Anti-inflammatory Drugs in Human Healthy Subjects and in Patients
Calcitonin Gene-Related Peptide as Target of Capsaicin Receptor in the Gut
Capsaicin for Osteoarthritis Pain
The Role of Capsaicin in Dermatology
Use of Vanilloids in Urologic Disorders.

Summary: This book contains complete information on Capsicum genetic resources, diversity, evolution, history and advances in capsicum improvement from classical breeding to whole genome sequencing, genomics, databases and its impact on next generation pepper breeding. Capsicum is one of the most important Solanaceae crops grown worldwide as vegetables and spices. Due to its high economic value and to meet the demands of enormous population growth amid biotic and abiotic stresses, there has been an ongoing breeding program utilizing available genetic resources with desired traits to increase the sustainable productivity of this crop for several decades. However, the precision breeding of this crop for desired traits only started with the advent of molecular markers. The recent advances in high-throughput genome sequencing technologies helped in the quick decoding of transcriptome, epigenome, nuclear and organeller genomes, thereby enhancing our understanding of the structure and function of the Capsicum genome, and helping in genomics assisted breeding. These advanced technologies coupled with conventional mapping have greatly contributed towards dissection and manipulation of economically important traits more precisely and made less time consuming.

Contents:
Intro; Preface to the Series; Preface to the Volume; Contents; Abbreviations; 1 The Capsicum Crop: An Introduction; Abstract; 1.1 Origin and Diffusion; 1.2 Economic and Culinary Importance; 1.3 The Properties of Pepper; 1.4 Genetic Resources and Breeding; References; 2 Genetic Resources of Capsicum; Abstract; 2.1 Introduction; 2.2 Domestication Syndrome; 2.3 Capsicum Species Complex and Gene Pools; 2.4 Discovery of Highly Pungent Landraces; 2.5 Discovery and Utilization of Genetic Resources for Stress Resistance; 2.5.1 Resistance to Biotic Stresses; 2.5.1.1 Anthracnose; 2.5.1.2 Bacterial Wilt 2.5.1.3 Phytophthora Root Rot2.5.1.4 Viruses; Potyviruses; Cucumovirus; Begomovirus; Tospoviruses; Tobamoviruses; 2.5.1.5 Root-Knot Nematode; 2.5.1.6 Insects; 2.5.2 Tolerance to Abiotic Stress; 2.5.2.1 Moisture Deficit Tolerance; 2.5.2.2 Heat and Salt Tolerance; 2.6 Conservation of Genetic Resources; 2.6.1 Ex Situ; 2.6.2 In Situ; 2.7 Future Outlook; References; 3 Capsicum Breeding: History and Development; Abstract; 3.1 Introduction; 3.2 History of Capsicum Breeding; 3.3 Current Breeding Objectives for Capsicum Improvement; 3.3.1 Specific Objectives for Sweet Pepper Breeding 3.4 Breeding Methods for Capsicums3.5 Other Strategies Utilized for Capsicum Improvement and Achievements; 3.5.1 Mutation Breeding; 3.5.2 Polyploidy Breeding; 3.5.3 Haploid Breeding; 3.5.4 Embryo Rescue; 3.5.5 Transgenic Development; 3.5.6 Marker-Assisted Breeding; 3.6 Limitations of Traditional Breeding; 3.7 Need of Molecular Breeding; 3.8 Future Prospects; References; 4 Cytology and DNA Content Variation of Capsicum Genomes; Abstract; 4.1 Introduction; 4.2 Phylogeny of Chili Peppers; 4.3 Basic Chromosome Number; 4.4 Karyotyping of Capsicum Species 4.5 Mapping of the 45S and 5S Ribosomal RNA Genes4.6 AgNOR Mapping; 4.7 DNA Content of Capsicum Species; 4.8 Concluding Remarks and Future Prospects; References; 5 Development and Evolution of Molecular Markers and Genetic Maps in Capsicum Species; Abstract; 5.1 Introduction; 5.2 Development and Evolution of Markers in Capsicum Species; 5.2.1 Biochemical Marker; 5.2.2 DNA Marker; 5.2.2.1 Restriction Fragment Length Polymorphism (RFLP); 5.2.2.2 Minisatellites: Variable Number of Tandem Repeat (VNTR); 5.2.2.3 Random Amplified Polymorphic DNA (RAPD); 5.2.2.4 Inter-simple Sequence Repeat (ISSR) 5.2.2.5 Amplified Fragment Length Polymorphism (AFLP)5.2.2.6 Simple Sequence Repeat (SSR); 5.2.2.7 Cleaved Amplified Polymorphic Sequences (CAPSs); 5.2.2.8 Sequence-Characterized Amplified Region (SCAR); 5.2.2.9 Single-Nucleotide Polymorphism (SNP) and Insertion/Deletion (InDel); 5.2.2.10 High-Throughput SNP Genotyping Systems; 5.3 Genetic Maps in Capsicum Species; 5.3.1 Interspecific Genetic Linkage Maps; 5.3.1.1 Capsicum annuum × Capsicum chinense; 5.3.1.2 Capsicum annuum × Capsicum frutescens; 5.3.1.3 Capsicum annuum × Capsicum baccatum; 5.3.2 Intraspecific Genetic Linkage Maps

Summary: This volume provides a comprehensive introduction and review of small bowel capsule endoscopy (SBCE). The book reviews the data regarding appropriate indications and contraindications for the implementation of small bowel capsule endoscopy, while discussing in detail the evolving role of SBCE in the treatment of obscure gastrointestinal bleeding, and the management of inflammatory bowel disease, small bowel polyposis syndromes, and refractory malabsorption. Topics such as complications of SBCE, methods to perform SBCE on patients with dysphagia or gastric emptying pathology, and understanding the normal anatomy of the gastrointestinal tract when viewed via SBCE are also discussed. In addition, an introduction to colon capsule technology and the next generation of small bowel capsule imaging is reviewed. The text is complemented by several illustrative cases that are demonstrated with both online full length videos as well as an online interactive companion that includes review questions to reinforce concepts learned in the text. Written by experts in the field, Capsule Endoscopy: A Guide to Becoming an Efficient and Effective Reader is an invaluable resource for novice capsule endoscopy readers, fellows in gastroenterology and hepatology, researchers, mid-level providers, residents, and medical students with an interest in learning how to implement and perform SBCE in the investigation of small bowel diseases.

Contents:
The History and Development of the Small Bowel Capsule/Comparison of Current Available Capsule Platforms
SBCE Indications and Contraindications? and the Logistics of Administering the Capsule? Preps, Prokinetics, Retention
Difficult Populations? Dysphagia/Partial SBOs/ICDs/Pediatrics
Capsule Endoscopy for Obscure Ganstrointestinal Bleeding.-The Utility of Capsule Endoscopy in Crohn?s disease
The Role of Capsule Endoscopy in the Diagnosis and Management of Celiac Disease and Refractory Diarrhea
Becoming an Efficient and Effective Reader of Capsule Endoscopy in Screening and Surveillance of Small Bowel Polyposis Syndromes and Masses
How to Read a Small Bowel Capsule Endoscopy Study
Normal versus Abnormal CE Images
Colon Capsule and the Future of Capsule Endoscopy.

Contents:
Carbohydrate-based vaccines : an overview / Julia Hütter and Bernd Lepenies
Glycans as vaccine antigens and adjuvants : immunological considerations / Stephanie Zimmermann and Bernd Lepenies
Glycan array platform as a tool to identify carbohydrate antigens / Li Xia and Jeffrey C. Gildersleeve
Antibody-carbohydrate recognition from docked ensembles using the AutoMap procedure / Tamir Dingjan, Mark Agostino, Paul A. Ramsland, and Elizabeth Yuriev
Generation of monoclonal antibodies against defined oligosaccharide antigens / Felix Broecker, Chakkumkal Anish, and Peter H. Seeberger
Murine whole-blood opsonophagocytosis assay to evaluate protection by antibodies raised against encapsulated extracellular bacteria / Guillaume Goyette-Desjardins, René Roy, and Mariela Segura
Determination of N-linked glycosylation in viral glycoproteins by negative ion mass spectrometry and ion mobility / David Bitto, David J. Harvey, Steinar Halldorsson, Katie J. Doores, Laura K. Pritchard, Juha T. Huiskonen, Thomas A. Bowden, and Max Crispin
N-glycosylation fingerprinting of viral glycoproteins by xCGE-LIF / René Hennig, Erdmann Rapp, Robert Kottler, Samanta Cajic, Matthias Borowiak, and Udo Reichl
Temporary conversion of protein amino groups to azides : a synthetic strategy for glycoconjugate vaccines / Tomasz Lipinski and David R. Bundle
Gold nanoparticles as carriers for synthetic glycoconjugate vaccines / Fabrizio Chiodo and Marco Marradi
Identification and characterization of carbohydrate-based adjuvants / Timo Johannssen and Bernd Lepenies
Characterization of carbohydrate vaccines by NMR spectroscopy / Francesco Berti and Neil Ravenscroft
Characterization of capsular polysaccharides and their glycoconjugates by hydrodynamic methods / Stephen E. Harding, Ali Saber Abdelhameed, Richard B. Gillis, Gordon A. Morris, and Gary G. Adams
Glycoconjugate vaccines : the regulatory framework / Christopher Jones.

Summary: This book serves as a practical guide for the use of carbon ions in cancer radiotherapy. On the basis of clinical experience with more than 7,000 patients with various types of tumors treated over a period of nearly 20 years at the National Institute of Radiological Sciences, step-by-step procedures and technological development of this modality are highlighted. The book is divided into two sections, the first covering the underlying principles of physics and biology, and the second section is a systematic review by tumor site, concentrating on the role of therapeutic techniques and the pitfalls in treatment planning. Readers will learn of the superior outcomes obtained with carbon-ion therapy for various types of tumors in terms of local control and toxicities. It is essential to understand that the carbon-ion beam is like a two-edged sword: unless it is used properly, it can increase the risk of severe injury to critical organs. In early series of dose-escalation studies, some patients experienced serious adverse effects such as skin ulcers, pneumonitis, intestinal ulcers, and bone necrosis, for which salvage surgery or hospitalization was required. To preclude such detrimental results, the adequacy of therapeutic techniques and dose fractionations was carefully examined in each case. In this way, significant improvements in treatment results have been achieved and major toxicities are no longer observed. With that knowledge, experts in relevant fields expand upon techniques for treatment delivery at each anatomical site, covering indications and optimal treatment planning. With its practical focus, this book will benefit radiation oncologists, medical physicists, medical dosimetrists, radiation therapists, and senior nurses whose work involves radiation therapy, as well as medical oncologists and others who are interested in radiation therapy.

Contents:
Part I. The History of Carbon-Ion Radiotherapy
1. History of Charged Particle Radiotherapy / Hirohiko Tsujii
Part II. An Overview of Carbon-Ion Radiotherapy
2. The Characteristics of Carbon-Ion Radiotherapy / Tadashi Kamada
3. Overview of the Heavy-Ion Medical Accelerator in Chiba (HIMAC) Practices / Tadashi Kamada
Part III. Radiobiology of Carbon-Ion Radiotherapy
4. Heavy-Ion Radiobiology / Yoshiya Furusawa
5. Biophysical Models and RBE / Naruhiro Matsufuji
Part IV. Carbon-Ion Radiotherapy System
6. Workflow of Carbon-Ion Radiotherapy / Toshiyuki Shirai and Yuka Takei
7. Beam-Delivery Systems / Shigekazu Fukuda, Takuji Furukawa, and Yoshiyuki Iwata
8. Dosimetry / Manabu Mizota and Akifumi Fukumura
9. Motion Management / Shinichiro Mori
10. Quality Assurance / Takuji Furukawa and Shinichiro Mori
Part V. Treatment Planning of Carbon-Ion Radiotherapy
11. Treatment Planning of Carbon-Ion Radiotherapy / Nobuyuki Kanematsu and Taku Inaniwa
Part VI. Facility Design
12. Facility Design of Carbon-Ion Radiotherapy / Koji Noda
Part VII. Oncology Information System
13. Oncology Information System / Yutaka Ando
Part VIII. Evaluation of Treatment Outcome
14. Evaluation of Treatment Outcomes Using the Heavy-Ion Medical Accelerator in Chiba (HIMAC) Approach / Tadashi Kamada
Part IX. Head and Neck Tumors
15. Cancer of the Head and Neck / Azusa Hasegawa
16. Malignant Melanoma of the Head and Neck / Ryo Takagi
17. Soft Tissue Sarcoma of the Head and Neck / Masashi Koto
Part X. Skull Base and Paracervical Tumors
18. Skull Base and Upper Cervical Spine Tumors / Masashi Koto
Part XI. Eye Tumors
19. Uveal Melanoma / Hiroshi Tsuji, Shingo Toyama, and Takuma Nomiya
20. Lacrimal Gland Tumors / Hiroshi Tsuji, Nobutaka Mizoguchi, and Takuma Nomiya
Part XII. Lung Tumors
21. Lung Cancer / Naoyoshi Yamamoto and Mio Nakajima
22. Metastatic Lung Tumors and Lymph Nodes / Naoyoshi Yamamoto and Mio Nakajima
Part XIII. GI Tract Tumors
23. Esophageal Cancer / Shigeo Yasuda
24. Postoperative Recurrence of Rectal Cancer / Shigeu Yamada, Satoshi Endo, Kohtaro Terashima, Makoto Shinoto, Shigeo Yasuda, Miho Shiomi, and Tetsuro Isozaki
Part XIV. Liver Tumors
25. Hepatocellular Carcinoma / Shigeo Yasuda
Part XV. Pancreatic Cancer
26. Pancreatic Cancer / Shigeu Yamada, Kohtaro Terashima, Makoto Shinoto, Shigeo Yasuda, Miho Shiomi, and Tetsuro Isozaki
Part XVI. Genitourinary Tumors
27. Prostate Cancer / Hiroshi Tsuji, Hitoshi Ishikawa, and Takuma Nomiya
28. Renal Cell Carcinoma / Takuma Nomiya and Hiroshi Tsuji
Part XVII. Gynecologic Tumors
29. Uterine Cancer / Masaru Wakatsuki
30. Gynecological Melanoma / Kumiko Karasawa
Part XVIII. Bone and Soft Tissue Sarcomas
31. Bone and Soft-Tissue Sarcomas / Reiko Imai
Part XIX. Other Tumors
32. Previously Irradiated Tumors / Masashi Koto
33. Metastatic Tumors / Kumiko Karasawa
34. Brain Tumors / Masashi Koto
35. Breast Cancer / Kumiko Karasawa.

Summary: Carbon Sequestration in Agricultural Ecosystems addresses basic processes of soil C dynamics and explains the underlying controls of technical and economic potential of soil C sequestration. It contains discussions on soil inorganic and organic C, and the factors affecting their stock and fluxes. After an introduction on agricultural land uses and their effects on the global C cycle; processes, factors and causes influencing SIC and SOC dynamics are presented in detail based on up-to-date scientific knowledge. Also discussed are processes affecting dynamics of SIC and SOC sequestration in soils of croplands and grasslands, and how agricultural practices affect them. This is followed by a description of SOC sequestration in wetlands under agricultural use, and those under agroforestry systems. Then, how the increasing biomass production for bioenergy and biofuel affects the SOC stocks of agroecosystems is presented. This is followed by a critical discussion on the importance of biochar to soil C sequestration in agroecosystems. The book concludes with an outlook about the importance of soils of agroecosystems for climate change policy. Focus of the book is on scientific understanding of SIC and SOC sequestration in agroecosystems. It lists a set of questions at the end of each chapter to stimulate thinking and promote academic dialogue. Each chapter lists pertinent references on the current research, and summarizes the present understanding while identifying the knowledge gaps for future research. It is timely because of the growing interests by the policy makers (as documented by the "4 per Thousand" initiative at COP21 in Paris, and the "Adapting African Agriculture" program at COP22 in Marrakech) in making soils and agriculture important to solutions of addressing the global issues. The book is a valuable source of information intended for use by graduate and undergraduate students, scientists, land managers, private sector, policy makers and the general public.

Contents:
Preface
1 Agricultural Land Use and the Global Carbon Cycle
2 Soil Carbon Stock
3 Carbon Sequestration in Cropland Soils
4 Carbon Sequestration in Grassland Soils
5 Carbon Sequestration in Wetland Soils
6 Agroforestry Systems
7 Biomass and Bioenergy.-8 Biochar
9 Importance of Soils of Agroecosystems for Climate Change Policy
Conclusions: The Way Forward.

Summary: The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification.

Contents:
Overview of the Carbonic Anhydrase Field
Physiological Functions of the Alpha Class of Carbonic Anhydrases
Catalytic Mechanism of [alpha]-Class Carbonic Anhydrases: CO2 Hydration and Proton Transfer
Structure and Catalytic Mechanism of b-Carbonic Anhydrases
Prokaryotic Carbonic Anhydrases of Earth?s Environment
Carboxysomal Carbonic Anhydrases
Carbonic Anhydrases and their Interplay with Acid/base-coupled Membrane Transporters
Carbonic Anhydrase Related Proteins: Molecular Biology and Evolution
Membrane Associated Carbonic Anhydrase IV (CA IV): A Personal and Historical Perspective
Carbonic Anhydrase Expression in Kidney and Renal Cancer: Implications for Diagnosis and Treatment
Carbonic Anhydrase IX: Regulation and Role in Cancer
Carbonic Anhydrase IX as an Imaging and Therapeutic Target for Tumors and Metastases
Carbonic Anhydrase IX (CAIX) as a Mediator of Hypoxia-induced Stress Response in Cancer Cells
Carbonic Anhydrases and Brain pH in the Control of Neruronal Excitability
Carbonic Anhydrase Inhibitors: Drug Design
Natural Products that Inhibit Carbonic Anhydrases
Glaucoma and the Application of Carbonic Anhydrase Inhibitors
Carbonic Anhydrase Inhibitors and High Altitude Illnesses
Thermal-Stable Carbonic Anhydrases: A Structural Overview
Carbonic Anhydrases in Industrial Applications.

Summary: This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) with a particular focus on inhibitor binding for drug design. X-ray crystallographic structures in combination with enzyme kinetic testing provide information on the interaction of CAs and their inhibitors, knowledge which is crucial for rational drug design. CAs are zinc carrying enzymes that catalyse the reversible interconversion of carbon dioxide and bicarbonate and are involved in numerous cellular processes. They are therefore a common target for drugs. The suppression of CA activities through inhibitory compounds has found application for example in diuretics and in glaucoma therapy. In this book methods used to determine binding thermodynamics of inhibitory compounds (Isothermal titration calorimetry, Fluorescent thermal shift assay/differential scanning fluorimetry and others) will be compared in detail. Also types and chemical synthesis of CA inhibitors, the use of antibodies against CAs as well as inhibitor application in animals are discussed.

Contents:
Final ToC tbd. 1) Description of human carbonic anhydrases (12 catalytically active human isoforms; isoforms as drug targets, enzymatic activity, catalytic mechanism, thermodynamics of protonation of the water molecule in the active site)
2) Thermal stabilities of all isoform CA catalytic domains
Thermodynamics of inhibitor binding to CAs (incl. intrinsic thermodynamics
not mentioned important subject in most CA literature)
3) Comparison of methods to determine inhibitor binding to CAs (ITC, FTSA, enzymatic activity assays)
4) Chemical synthesis of CA inhibitors
5) X-ray crystallographic structures of CAs and their complexes with inhibitors
6) Antibodies against CAs.

Contents:
1. Preface
Chemical carcinogenesis in mice as a model of human cancer: Pros and cons, Lorenzo Galluzzi
2. MPA/DMBA-driven mammary carcinomas, Aitziber Buqué Martinez
3. Dimethylbenz(a)anthracene-Induced Mammary Tumorigenesis in mice, Isabelle Plante
4. Urethane-induced lung carcinogenesis, Silvano Sozzani
5. Methylcholanthrene-induced fibrosarcomas, Awen Gallimore
6. BBN-driven bladder carcinomas
Janos Terzic
7. Oral squamous cell carcinomas driven by 4NQO, Nancy J. Philp
8. Analysing skin tumor development in mice by the DMBA/TPA model, Cord Brakebusch
9. DSS/AOM-driven colorectal carcinomas, David C. Montrose
10. Diethylnitrosamine-induced liver tumorigenesis in mice, Peter Hasselblatt
11. Two-stage 3-methylcholanthrene and butylated hydroxytoluene-induced lung carcinogenesis in mice, Alison K. Bauer
12. Lung carcinomas induced by NNK and LPS, Peter Di
13. Pristane-induced mammary carcinomas, Bae Hoon Lee
14. The 4-NQO mouse model: an update on a well-established in vivo model of oral carcinogenesis, Pierre Saintigny.

Summary: Carcinomas of the larynx and hypopharynx present unique challenges when it comes to their assessment and management. Management involves the essential dilemma of optimizing cure rates while also ensuring that potential disability due to compromised airway, voice and swallowing is minimized. Treatment decisions involve careful disease assessment, judicious multispecialty decision-making, and subsequent meticulous implementation of the selected treatment modalities.The critical nature of each of these steps has led to dramatic advances in assessment techniques (radiology, endoscopy and photography, stroboscopy, narrow band imaging, contact endoscopy) and also in treatment methods (radiation therapy, combined concurrent chemo-radiation, combined sequential chemo-radiation, trans-oral CO2 laser and robotic surgery, partial laryngectomy, total laryngectomy, extended total laryngectomy). As such, treatment decisions have become increasingly complex with the twin objectives of maximizing cure as well as function preservation and are based on tumor stage, tumor location, systemic co-morbidities, nutritional status, patient priorities, and social and economic factors.    This multidisciplinary book has been written by a team of editors with considerable experience and expertise in these critical areas and a deep understanding of teamwork and the strengths and limitations of individual technologies and treatments. It presents a homogeneous and unbiased view that is applicable to all specialties involved in the care of larynx and hypopharynx cancers.

Summary: This concise book meets the market need for an accessible and up-to-date guide on understanding and managing cardiac anesthesia patients. It reflects the continual evolution of the very complex field of cardiac anesthesia. Organized into 10 sections, beginning chapters comprehensively examine the foundational concepts of cardiovascular function. The book then functions as a practical guide for clinical settings, including patient evaluation, operating room and anesthetic management, and postoperative care. Each chapter is authored by experienced cardiac anesthesiologists and many are supplemented by high quality, images, videos and tables. Written for the student, trainee, and junior cardiac anesthesiologist, Cardiac Anesthesia: The Basics of Evaluation and Management covers the core concepts needed to treat the cardiac surgery patient and to the skillset needed to succeed in this field.

Contents:
Chapter 01 Basic Cardiovascular Anatomy
Chapter 02 Basic Cardiovascular Physiology
Chapter 03 Basic cardiovascular pharmacology
Chapter 04 Basic ECG and Common Arrhythmias for the Cardiac Surgery Patient
Chapter 05 Preoperative evaluation and risk assessment for the cardiac surgery patient
Chapter 06 A Guide to Interpreting Preoperative Cardiac Studies
Chapter 07 Medically optimizing the cardiac surgical patient
Chapter 08 Cardiac Operating Room Setup and Preparation of the Patient for Surgery
Chapter 09 Intraoperative Hemodynamic monitoring for the cardiac surgery patient
Chapter 10 The fundamentals of Transthoracic Echocardiography (TTE) and the Focused Assessment with Sonography in Trauma (FAST) examination
Chapter 11 Common Pathophysiologic Findings on TTE and FAST Examination
Chapter 12 The Fundamentals of Transesophageal Echocardiography
Chapter 13 Fundamentals of Cardiopulmonary Bypass Machine Equipment and Technique
Chapter 14 Myocardial Preservation During Cardiopulmonary Bypass
Chapter 15 Blood Conservation in Cardiac Surgery
Chapter 16 Anesthetic Management During Cardiopulmonary Bypass
Chapter 17 Weaning from Cardiopulmonary Bypass and Management of Difficulties
Chapter 18 Anesthetic management for Conventional myocardial revascularization
Chapter 19 Anesthetic management AND Surgical Considerations for the Patient Undergoing Off-Pump Coronary Artery Bypass Grafting
Chapter 20 Anaesthesia for endovascular Thoracic Aortic Aneurysm repair (TEVAR)
Chapter 21 Anesthetic management for valvular heart disease
Chapter 22 Anesthetic Management for Thoracic Aortic Procedures
Chapter 23 Anesthetic Management for Minimally Invasive Cardiac Surgery
Chapter 24 Anesthetic management for heart failure and Transplantation
Chapter 25 Anesthetic management for Pulmonary Thromoendarterectomy
Chapter 26 The Complications of Cardiac Surgery
Chapter 27 Anesthesia for cardioversion and cardiac ablation procedures
Chapter 28 Anesthesia for Watchman procedure
Chapter 29 Anesthesia for TAVR procedure
Chapter 30 Anesthetic Considerations for Transcatheter Mitral Valve Repair with the MitraClip Device
Chapter 31 Anesthesia for Laser Lead Extraction
Chapter 32 Understanding Devices in the cardiac operating room
Chapter 33 Anaesthesia for endovascular aortic Aneurysm repair (EVAR)
Chapter 34 Anesthesia for Open Abdominal Aortic Aneurysm
Chapter 35 Anesthesia for Lower Extremity Bypass
Chapter 36 Anesthesia for Carotid Endarterectomy
Chapter 37 Anesthesia considerations for upper extremity arteriovenous fistulas
Chapter 38 Post-Operative Care for The Adult Cardiac Surgery Patient.

Summary: This book provides a practical approach to cardiac perioperative care. The step-by-step format guides readers from basic concepts, such as cardiac physiology and pharmacology, to anesthetic management of specific cardiac surgical procedures, including cardiac percutaneous interventions, management of specific cardiac disease, circulatory support, and organ protection strategies. Written by experienced cardiac anesthesiologists in Europe, USA, Canada and Australia, this book provides an international perspective on the topic with each chapter referring the reader to the relevant key reading. Cardiac Anesthesia and Postoperative Care in the 21st Century is aimed at new consultants in cardiac anesthesia and intensive care, residents, and fellows. It may also be of interest to perfusionists and is a refreshing update for the experienced cardiac anesthesiologist.

Contents:
Part 1: Basic Concepts
Anatomy and pathology of the heart
Cardiovascular physiology
Cardiovascular pharmacology
Preoperative assesment and decisions based in test
Monitoring for cardiac surgery
Echocardiography
Angiogram
Cardiopulmonary bypass
Pacemaker and other implantable devices
Hemostasia and coagulation monitoring: Tromboelastogram, ROTEM and platelets mapping
Part 2: Intraoperative Management
General principles of anesthesia for adult cardiac surgery
Fluid management and blood transfusion
Cardiac electrophysiological interventions
Myocardial revascularization
Valvular surgery
Interventional cardiac procedures
Aortic arch surgery
Adult congenital heart disease
Heart transplantation
Intra-aortic balloon pump and mechanical circulatory support
Part 3: Postoperative Care
Basic concepts of critical care following cardiac surgery
Issues related to the type of surgery
Sedation, pain relief and respiratory weaning
Hemodynamic complications
Acute kidney injury & management
Neurocognitive dysfunction and delirium
Cardiac arrest and post-cardiac arrest management
Management of mechanical circulatory support
Management of heart transplant
Infections and management.

Summary: "An essential resource for anesthesiologists new to the cardiac operating room Cardiac Anesthesia and Transesophageal Echocardiography, Second Edition is a fast and effective way for anesthesia trainees to acquire the skills necessary to successfully navigate the cardiac operating room. Clinically focused, this unique guide imparts the basic principles of both cardiac anesthesia and echocardiography in a way that reflects the realities of real-world practice. Whether you are looking for a concise, easy-to-read introduction to cardiac anesthesiology or a primer on incorporating the basic principles of cardiac anesthesiology and perioperative echocardiography into real-world practice, Cardiac Anesthesia and Transesophageal Echocardiography is the trusted one-stop guide to mastery of these two critical topics. This edition includes online access to nearly 100 narrated, labeled TEE clips that illustrate normal and abnormal echocardiographic views. Each clip is keyed to a specific passage in the text, which provides the reader with a true multimedia learning experience"-- Provided by publisher.

Contents:
Introduction to Perioperative Echocardiography
Chapter 1: Preoperative Evaluation of the Heart Surgery Patient
Chapter 2: Hemodynamics and Cardiac Anesthesia
Chapter 3: Perioperative Rhythm Abnormalities
Chapter 4: Routine Cardiac Surgery and Anesthesia
Chapter 5: The Complicated Patient for Cardiac Anesthesia and Surgery
Chapter 6: Aortic Valve Disease
Chapter 7: Mitral Valve Disease
Chapter 8: Right Heart Valves and Function
Chapter 9: Anesthesia for Repair of Diseases of Thoracic Aorta
Chapter 10: Hypertrophic Obstructive Cardiomyopathy and Cardiac Masses
Chapter 11: Ventricular Assist Devices and Heart Transplantation
Chapter 12: Anesthesia for Patients With Congenital Heart Disease
Chapter 13: Off-Pump, Robotic, and Minimally Invasive Heart Surgery
Chapter 14: The Postoperative Care of the Cardiac Surgery Patient
Chapter 15: Anesthesia for Electrophysiology, Hybrid, and Catheterization Procedures
Chapter 16: Coagulopathy, Bleeding, and Cardiac Anesthesia Emergencies
Chapter 17: Cardiopulmonary Bypass.

Summary: The past 50 years have witnessed the growth and evolution of clinical electrophysiology from a field whose goals were simply to understand of the mechanisms of arrhythmia to one of significant therapeutic impact. The development and refinement of implantable devices and catheter ablation have made non-pharmacological therapy a treatment of choice for most arrhythmias encountered in clinical practice. Cardiac Arrhythmias: From Basic Mechanism To State-of-the-Art Management provides an electrophysiologic approach to arrhythmias predicated on the hypothesis that a better understanding of the mechanisms of arrhythmias will lead to more successful and rationally chosen therapy. It encompasses the anatomy of arrhythmias, diagnostic methods, comorbid diseases, and the treatment of all forms of cardiac arrhythmias. It discusses modern ablation and mapping techniques, while reviews the methodology required to define the mechanism and site of origin of arrhythmias, so that safe and effective therapy can be chosen. It will thus be of interest to all involved in the management of these patients, from clinical cardiac electrophysiologists themselves to clinical cardiologists, interventionalists, cardiac surgeons, emergency medicine physicians and researchers in basic cardiac science.

Contents:
1. Anatomy and Physiology of the Atrioventricular Node: Basic Concepts / Ambrose S. Kibos and Blanca F. Calinescu
2. Anatomy and Physiology of the Atrioventricular Node: What Do We Know Today? / Hidekazu Miyazaki
3. Molecular Basis of Arrhythmias Associated with the Cardiac Conduction System / Sunil Jit R.J. Logantha, Andrew J. Atkinson, Mark R. Boyett, and Halina Dobrzynski
4. Functional Anatomy in Arrhythmias and Vascular Support of the Conduction System / Cristian Stătescu, Radu A. Sascău, and Cătălina Arsenescu Georgescu
5. Autonomic Control of Cardiac Arrhythmia / Kieran E. Brack and G. André Ng
6. Neural Mechanisms of Arrhythmia / Hyung-Wook Park and Jeong-Gwan Cho
7. Understanding the Genetic Basis of Atrial Fibrillation: Towards a Pharmacogenetic Approach for Arrhythmia Treatment / Jason D. Roberts and Michael H. Gollob
8. Importance of Isthmus Structure in the Right Atrium / Jiunn-Lee Lin, Ling-Ping Lai, Liang-Yu Lin, Chia-Ti Tsai, and Chih-Chieh Yu
9. Channelopathies and Heart Disease / Bogdan Amuzescu, Bogdan Istrate, and Sorin Musat
10. Late Open Artery Hypothesis and Cardiac Electrical Stability / Craig Steven McLachlan, Brett Hambly, and Mark McGuire
11. The Clinical Utility of 12-Lead Resting ECG in the Era of Ablation Strategies / Jang-Ho Bae, Taek-Geun Kwon, and Ki-Hong Kim
12. Long-Term ECG (Holter) Monitoring and Head-Up Tilt Test / Santosh Kumar Dora
13. Echocardiography in Arrhythmias / Ioan Tiberiu Nanea
14. Electrophysiologic Testing and Cardiac Mapping / Mitsunori Maruyama and Teppei Yamamoto
15. How to Differentiate Between AVRT, AT, AVNRT, and Junctional Tachycardia Using the Baseline ECG and Intracardiac Tracings / Sharon Shen and Bradley P. Knight
16. Recognizing the Origin of Ventricular Premature Depolarization During Sinus Rhythm and During Non- sustained Tachycardia / Seow Swee-Chong
17. Detection and Management of Atrial Fibrillation in Patients with Stroke or TIA in Clinical Practice / Jerzy Krupinski, Jorge de Francisco, and Sonia Huertas
18. Ventricular Arrhythmias During Acute Myocardial Ischemia/Infarction: Mechanisms and Management / Theofilos M. Kolettis
19. Arrhythmias and Hypertrophic Cardiomyopathy / Krishnakumar Nair, Douglas Cameron, Gil Moravsky, and Jagdish Butany
20. Lai Tai, the Mysterious Death of Young Thai Men / Gumpanart Veerakul, Lertlak Chaothawee, Kriengkrai Jirasirirojanakorn, and Koonlawee Nademanee
21. Cardiac Arrest Arrhythmias / Riccardo Proietti, Jacqueline Joza, Florea Costea, Mihai Toma, Dan Mănăstireanu, and Vidal Essebag
22. Electrical Storm: Recent Advances / Mitsunori Maruyama and Teppei Yamamoto
23. Electrical Storm: Clinical Management / Sofia Metaxa, Spyridon Koulouris, and Antonis S. Manolis
24. Cellular Pharmacology of Cardiac Automaticity and Conduction: Implications in Antiarrhythmic Drug Assessment / Gary Aistrup
25. Biophysical and Molecular Targets / Mark Slevin, Michael Carroll, Chris Murgatroyd, and Garry McDowell
26. Proarrhythmia (Secondary) / Debabrata Dash
27. Connexin-43 Expression: A Therapeutic Target for the Treatment of Ventricular Tachycardia / Craig Steven McLachlan, Zakaria Ali Moh Almsherqi, Brett Hambly, and Mark McGuire
28. Biophysics of Modern Ablation Techniques and Their Limitations / Erik Wissner and Andreas Metzner
29. Cardiac Imaging to Assist Complex Ablation Procedures / Alejandro Jimenez Restrepo and Timm M. Dickfeld
30. AVNRT Ablation: Significance of Anatomic Findings and Nodal Physiology Félix Ayala-Paredes, Jean-Francois Roux, and Mariano Badra Verdu
31. Mechanisms of Atrial Fibrillation / Rishi Arora and Hemantha K. Koduri
32. Importance of Left Atrial Imaging in Catheter Ablation of Atrial Fibrillation / Seil Oh, Youngjin Cho, and Eue-Keun Choi
33. Atrial Fibrillation Ablation: From Guidelines to Clinical Reality / Joseph M. Lee and Steven M. Markowitz
34. Atrial Fibrillation: Should Cardiac Surgeons Be Consulted? / Max Baghai, Randolph H.L. Wong, Innes Y.P. Wan, and Malcolm John Underwood
35. Atrial Arrhythmias After AF Ablation: Challenge for the Next Decade? / Tamás Tahin and Gábor Széplaki
36. Cavotricuspid Isthmus Anatomy Particularities in Atrial Flutter Ablation / Liviu Chiriac, Gabriel Cristian, Romi Bolohan, and Ion C. Ţintoiu
37. Location of Accessory Pathways in WPW: What and How Should We Ablate / Bieito Campos, Xavier Viñolas, José M. Guerra, Concepción Alonso, and Enrique Rodríguez
38. VT Ablation Importance of Linear Lesions and Late Potentials / Cristiano Pisani, Sissy Lara Melo, Carina Hardy, and Mauricio Scanavacca
39. Programmed Stimulation During Mapping and Ablation of VT / Yaariv Khaykin
40. Catheter Ablation in Pediatric and Congenital Heart Disease / Steven B. Fishberger
41. Interventional Electrophysiology in Patients with Congenital Heart Disease / Sissy Lara Melo, Cristiano Pisani, Eduardo Sosa, and Mauricio Scanavacca
42. Epicardial Mapping and Ablation of Cardiac Arrhythmias / Robert Lemery
43. Robotic Ablation in Electrophysiology / Ferdi Akca, Lara Dabiri, and Tamas Szili-Torok
44. Strategies for Restoring Cardiac Synchrony by Cardiac Pacing / Gabriel Cristian, Ecaterina Bontas, Liviu Chiriac, Silviu Ionel Dumitrescu, and Ion C. Ţintoiu
45. Device Therapy for Bradycardias / Chung-Wah Siu and Hung-Fat Tse
46. Pacemaker Dependence After Atrioventricular Node Ablation / Joseph Yat-Sun Chan and Cheuk-Man Yu
47. Pacing Site: From Theory to Practice / Cristian Stătescu and Cătălina Arsenescu Georgescu
48. Implantable Cardioverter Defibrillators in the Pediatric and Congenital Heart Population / Steven B. Fishberger
49. Sensing Issues in CRT Devices / Giuseppe Stabile, Assunta Iuliano, and Roberto Ospizio
50. Cardiac Resynchronization Therapy: Do Benefits Justify the Costs and Are They Sustained Over the Long Term? / Chin-Pang Chan and Cheuk-Man Yu
51. Complications of Cardiac Implantable Electronic Devices (CIED) / Sorin Pescariu and Raluca Sosdean
52. Peri-device Implantation Anticoagulation Management: Evidence and Clinical Implications / Alexander Omelchenko, Martin Bernier, David Birnie, and Vidal Essebag.

Summary: Like the first edition, this book represents our personal approach to patients with cardiac arrhythmias. Nonetheless, it would be unrealistic to expect 3 electrophysiologists to have entirely uniform approaches to diagnosis and therapy. Hence, the primary author's views in individual chapters prevailed when there were minor differences in approach. Each of us reviewed all the chapters and made recommendations for change. In the end, we did not feel there were any substantial differences in our approach to patient care and were comfortable in signing off on the total content.

Contents:
Part I: Basic Electrocardiographic Observations and Clinical Electrophysiologic Correlates
Chapter 1: Cardiac Conduction
Chapter 2: Electrocardiographic Consequences of Atrial and Ventricular Ectopy
Chapter 3: Bundle Branch Block
Chapter 4: Apparent Paradoxical Conduction
Chapter 5: Mechanisms of Tachycardia
Part II: Arrhythmias
Chapter 6: Supraventricular Tachycardia
Chapter 7: Preexcitation Syndromes
Chapter 8: Ventricular Tachycardia
Chapter 9: Atrial Fibrillation
Chapter 10: Bradycardia: Causes of Pauses
Part III: Clinical Presentations
Chapter 11: Electrocardiographic Abnormalities in Asymptomatic Individuals
Chapter 12: Narrow QRS Tachycardia
Chapter 13: Wide QRS Tachycardia
Chapter 14: Undiagnosed Syncope, Dizzy Spells, Palpitations
Chapter 15: Sudden Cardiac Arrest/Sudden Cardiac Death
Part IV: Methods and Therapy
Chapter 16: Electrophysiologic Testing and Diagnostic Maneuvers
Chapter 17: Catheter Ablation of Supraventricular Tachycardias
Chapter 18: Catheter Ablation of Ventricular Tachyarrhythmias
Chapter 19: Cardiac Implantable Electronic Devices.

Summary: This book provides up-to-date, user-friendly and comprehensive guidance on the evaluation, diagnosis, and medical and surgical treatment of cardiac arrhythmias. This ensures that that this title aids every trainee and practicising cardiologist, cardiac electrophysiologist, cardiac surgeon, vascular surgeon, diabetologist, cardiac radiologist and any physician who manages cardiac patients. Cardiovascular Medicine: Cardiac Arrhythmias, Pacing and Sudden Death covers every aspect of cardiac arrhythmias, from cardiac signs and symptoms through imaging and the genetic basis for disease to surgery, interventions, treatment and preventive cardiology. This coverage is presented with consistent chapter organization, clear design, and engaging text that includes user-friendly features such as tables, lists and treatment boxes.

Contents:
Basic Electrophysiology
Pathophysiology of Atrial Fibrillation
Genomics of cardiac arrhythmias
Channelopathies: Clinical Presentation and Genetics.-Extended ECG monitoring
Sudden Cardiac Death: Methods of Risk Prediction
Electrophysiologic Testing and Cardiac Mapping
Antiarrhythmic Drug Management of Atrial Fibrillation
Anticoagulants for atrial fibrillation
Cardiac pacemakers
Implantable and Wearable Defibrillator Therapy
Atrial Fibrillation Ablation
Ventricular Tachycardia Ablation
Supraventricular Tachycardia
Clinical Management of Atrial Fibrillation
Ventricular Tachycardia and Fibrillation in Patients with Structural Heart Disease
Ventricular Arrhythmias in the Absence of Structural Heart Disease
Bradyarrhythmias/heart blocks
Syncope and Risk of Sudden Death
Management of Ventricular Arrhtyhmias in Nonischemic Cardiomyopathic Syndromes
Arrhythmias in Congenital Heart Disease
Arrhythmias in Special Populations.

Summary: The updated and expanded second edition of this book presents a contemporary review of the basic science, engineering technology, and clinical practice of cardiac bioelectric therapy. It covers the rapidly expanding technological development of pacemakers and defibrillators as well as ablative therapy, electrophysiological mapping, and other clinical diagnostic and therapeutic breakthroughs. The book highlights many different aspects of bioelectric therapy, including history, biophysical and computational concepts, basic electrophysiology studies, engineering technology advances, and clinical perspectives. In this revised edition, leading clinical and basic electrophysiologists share their perspectives on the science behind the mechanisms of cardiac arrhythmias; breakthrough technologies for scientific and clinical investigation of heart rhythm disorders; theoretical conceptualization of arrhythmias and treatment using state-of-the-art computational approaches; and novel approaches to treatment of cardiac arrhythmias using implantable devices, percutaneous ablation therapies, machine learning, and other approaches. The Second Edition of Cardiac Bioelectric Therapy is an essential resource for physicians, residents, fellows, and graduate students in clinical cardiac electrophysiology, cardiology, and cardiac surgery as well as researchers, professionals, and students in biomedical, mechanical, and electrical engineering.

Contents:
Part I. Ischemic Heart Disease
1. Pre-analytical factors and analytical issues affecting interpretation of cardiovascular biomarkers
2. Troponin basics for clinicians
3. Unique aspects of high sensitivity assays: what are they, why do we need them, and how do we use them?
4. Evaluation of patients presenting with chest pain in the emergency department: where do troponins fit in?
5. Using cardiac troponins in patients with acute myocardial infarction
6. What is a Type 2 myocardial infaction: how is it recognized and what should one do to establish that diagnosis?
7. Use of cardiac troponin in patients with heart failure
8. Elevated cTn in other acute situations such as atrial fibrillation, sepsis, respiratory failure, and gastrointestinal bleeding
9. Use of cTn for detection of more chronic disease states
10. Use of high-sensitive cTn assays for the evaluation of patients potentially at risk for cardiovascular disease
11. Other biomarkers in acute coronary syndrome
12. Newer lipid markers: apolipoprotein B, LDL particle concentration, and triglyceride-rich lipoproteins, when are they needed?
Part II. Heart Failure
12. Natriuretic peptides: physiology for the clinician
14. Natriuretic peptides: basic analytic considerations
15. Natriuretic peptide use in screening in the community
16. Natriuretic peptide use in the emergency department
17. Heart failure: natriuretic peptide use in the hospital
18. Natriuretic peptide guided therapy in outpatient heart failure management
19. Caveats using natriuretic peptide levels
20. Gaps in our biomarker armamentarium: what novel biomarkers might be synergistic in patients with acute disease
21. Biomarkers in heart failure: ST2
22. Biomarkers in heart failure: procalcitonin
23. Novel biomarkers in heart failure: adrenomedullin and proenkephalin
24. Biomarkers in specific disease states: cardio-oncology
25. Biomarkers of sarcopenia and mitochondrial dysfunction
26. Biomarkers in arrhythmias, sudden death, and device therapy
27. Biomarkers in cardio-renal dysfunction
28. Biomarkers in heart failure with preserved ejection fraction
Index.

Summary: Congenital cardiology continues to advance at a rapid pace, with recent decades witnessing exceptional growth in the number and range of catheter-based interventions. This handbook is an ideal, up-to-date guide to the application of these procedures across the entire patient age range, from fetal life through to adulthood. Clear instruction is offered on techniques of vascular access, valve dilatation, angioplasty, stent implantation, defect closure, defect creation, pulmonary valve implantation, and the hybrid approach, as well as miscellaneous other procedures. Topics are approached using a step-by-step format, ensuring that the reader will immediately be able to access information relevant to daily practice. Many explanatory figures and drawings are included in each chapter in order to clarify further how to plan, perform, and evaluate diagnostic and interventional procedures in the field of congenital heart disease. Attention is drawn to important tips and tricks that will assist in achieving optimal outcomes. Besides the detailed descriptions of procedures, background information is provided on patient preparation, anesthesia, instrumentation, and hemodynamics. At the end of the book, an appendix includes additional general equations and BSA and oxygen consumption charts. This handbook will be an invaluable tool and a comprehensive companion for all who work in the field of congenital heart disease.

Contents:
Section I General
Section II : Vascular access
Section III : Step-by-step : Valve dilatation.-Vessels treatment
Section IV Step-by-step: closure of defects.- Section V Step-by-step: creating a defect.- Section VI Step-by-step: Pulmonary Valve implantation
Section VII Step-by-step: principles of hybrid approach.- Section VIII Step-by-step: Miscellanea
Section IX Tables and charts: Appendix.

Summary: The second edition of this handbook is an up-to-date guide to the application of catheter-based interventions across the entire age range of congenital heart disease patients, from fetal life through to adulthood. It considers the changes and improvements that have occurred during the last few years in terms of new procedures, new tools and devices (in particular in the field of valves), new imaging and pre-procedural strategies, such as 3D-printing, 3D- rotational angiography and fusion imaging. It provides readers with clear instructions on techniques for vascular access, valve dilatation, angioplasty, stent implantation, defect closure, defect creation, pulmonary valve implantation and on the hybrid approach, as well as on various other procedures. As in the first edition, topics are approached using a step-by-step format, ensuring that readers can immediately access the information relevant to their daily practice. Numerous explanatory figures and drawings are included in each chapter in order to further clarify how to plan, perform and evaluate diagnostic and interventional procedures in the field of congenital heart disease. It also highlights important tips and tricks that will assist health operators in achieving optimal outcomes, and includes an appendix with additional general equations and BSA, and oxygen consumption charts. This practical guide will be a valuable resource for surgeons and cardiologists in their daily clinical practice.

Contents:
PART I) GENERAL 1) Informed Consent
2) Anaesthesiological Management of the Paediatric Patient in the Catheterisation Laboratory
3) Antibiotics and Anticoagulation
4) 4) Angiography: Basics and Contrast Media
5) Angiography: Standard Projections / Radiation Exposure
6) Catheters and Wires
7) Balloons
8) Stents
9) Transcatheter Valve Devices in Congenital Heart Disease
10) Adult Tools Relevant For Congenital Heart Disease
11) Hemodynamic Assessment: Pressures, Flow, Resistances and Vasoreactive Testing
12) Congenital Heart Disease: An Integrated Care Approach
PART II) VASCULAR ACCESS 13) The Usual Vascular Access
14) Unusual Access
15) Hemostasis
16) Access Complications and Management
17) Transseptal Access
18) Hybrid Accesses
PART III) FETAL PROCEDURES 19) Fetal Interventions
PART IV) STEP-BY-STEP PROCEDURES: VALVE DILATATION 20) Aortic Valvular Stenosis
21) Pulmonary Valvular Stenosis
22) Pulmonary Atresia and Intact Venreicular Septum
23) Percutaneous Transcatheter Balloon Mitral Commissurotomy
PART V) STEP-BY-STEP PROCEDURES: VESSEL TREATMENT 24) Stent Implantation in Patients with Pulmonary Arterial Stenosis
25) Aortic Coarctation
26) The Role of Transcatheter Interventions in Middle Aortic Syndrome
27) Reopening of Peripheral and Central Arteries and Veins
28) PDA Stenting in Duct-dependent Pulmonary Circulation
29) PDA Stenting in Duct-dependent Systemic Circulation
PART VI) STEP-BY-STEP PROCEDURES: CLOSING OR CREATING A DEFECT 30) Step-by-step Closure of Atrial Septal Defects (ASDs)
31) Step-by-step Device Closure of Persistent Foramen Ovale (PFO)
32) Fontan Fenestrations Closure
33) Ventricular Septal Defect
34) Patent Ductus Arteriosus Closure
35) Percutaneous Closure of PDA in Premature Babies
36) Closure of Coronary Arterial Fistulas
37) Vessel Embolization: Transcatheter Embolization of Pulmonary Arteriovenous Malformations and Aortopulmonary Collateral Arteries
38) Closure of Residual Post-surgical Defects
39) ASD Closure in Special Situations: Elderly, PA-IVS
40) Creating an Interatrial Communication
41) Transcatheter Correction of the Superior Sinus Venosus ASD
PART VII) STEP-BY-STEP PROCEDURES: VALVE IMPLANTATION 42) Melody Valve Implantation in Pulmonary Position
43) SAPIEN XT Valve Implantation in the Pulmonary Position
44) Percutaneous Tricuspid Valve Implantation
45) Novel Self-Expanding Pulmonary Valves and Devices
46) Approaches to Large or Complex Right Ventricular Outflow Tract
PART VIII) STEP-BY-STEP PROCEDURES: PRINCIPLES OF HYBRID APPROACH 47) Hybrid Approach in Hypoplastic Left Heart Syndrome (HLHS)
48) Hybrid Approach: Defect Closure
49) Hybrid Approach: Stent Implantation
PART IX) STEP-BY-STEP PROCEDURES: MISCELLANEA 50) Retrieval Techniques
51) Pericardiocentesis
52) Endomyocardial Biopsies
53) Evaluations Before Partial and Total Cavopulmonary Connections
54) Hemodynamics in Pericardial and Myocardial Diseases
55) Imaging and Treating Coronary Arteries in Children
56) Transcatheter Treatments in PA-VSD-MAPCAs
57) Stenting of the Right Ventricular Outflow Tract as Initial Palliation for Fallot-Type Lesions
PART X) IMAGING TECHNIQUES 58) The Use of 3D Rotational Angiography in Congenital Heart Disease
59) Intracardiac Echocardiography
60) Three Dimensional Transoesophageal Echocardiography in Diagnosis and Transcatheter Treatment of Congenital Cardiac Defects
61) 3D Mapping Live Integration and Overlay of 3D Data from MRI and CT for Improved Guidance of Interventional Cardiac Therapy
62) 3D Printing and Engineering Tools Relevant to Plan a Transcatheter Procedure
63) Development of a Quality Improvement Culture in the Congenital Cardiac Catheterization Laboratory
64) Quality Improvement Tools and Risk Mitigation in the Congenital Cardiac Catheterization Laboratory
65) Hemodynamic Formulae, Calculations and Charts.

Summary: Cardiac computed tomography (CT) has become a highly accurate diagnostic modality that continues to attract increasing attention. This extensively illustrated book aims to assist the reader in integrating cardiac CT into daily clinical practice, while also reviewing its current technical status and applications. Clear guidance is provided on the performance and interpretation of imaging using the latest technology, which offers greater coverage, better spatial resolution, and faster imaging while also providing functional information about cardiac diseases. The specific features of scanners from all four main vendors, including those that have only recently become available, are presented. Among the wide range of applications and issues discussed are coronary calcium scoring, coronary artery bypass grafts, stents, and anomalies, cardiac valves and function, congenital and acquired heart disease, and radiation exposure. Upcoming clinical uses of cardiac CT, such as hybrid imaging, preparation and follow-up after valve replacement, electrophysiology applications, myocardial perfusion and fractional flow reserve assessment, and plaque imaging, are also explored.

Contents:
Introduction
Technical and Personnel Requirements
Anatomy
Cardiac CT in Clinical Practice
Clinical Indications
Patient Preparation
Physics Background and Radiation Exposure
Examination and Reconstruction
Examinations on Different CT Scanners
Reading and Reporting
Coronary Artery Calcium
Coronary Artery Bypass Grafts
Coronary Artery Stents
Coronary Artery Plaques
Cardiac Function
Cardiac Valves
Transcatheter Aortic Valve Interventions
Pulmonic Valve Implantation, Mitral Valve Repair, and Left Atrial Appendage Closure
Myocardial Perfusion and Fractional Flow Reserve
Hybrid Imaging
Electrophysiology Interventions
Coronary Artery Anomalies
Congenital and Acquired Heart Disease
Typical Clinical Examples
Results of Clinical Studies
Outlook.

Summary: Over the past few decades there have been major advances in computed tomography (CT) to improve the performance of cardiac imaging. Thanks to the improved scanning speed, power boost tubes, and increased-width detectors, the latest CT technology delivers greater coverage, better spatial and temporal resolution, and functional information on cardiac diseases. Focusing on cardiac CT imaging, this book offers case-based information on cardiac diseases, presents the current technical status, and highlights applications, helping readers systematically understand how cardiac CTs are performed and interpreted in clinical practice. Divided into six chapters, it broadly discusses the characteristics of CT imaging and its applications to coronary artery disease (CAD); non-atherosclerotic coronary artery disease; congenital heart disease; cardiac neoplasms; cardiomyopathy and aortic diseases.

Contents:
Reversible myocardial ischemia
Myocardial infarction
Coronary artery stent implantation
Coronary artery in-stent restenosis
Dual-energy evaluation of high calcium score (>400) coronary artery
Dual-energy evaluation of coronary artery stent
Coronary artery bypass grafting
Familial Hypercholesterolemia (FH)
Takayasu's arteritis
Kawasaki disease (KD)
Behcets disease (BD)
Fibromuscular Dysplasia
Coronary artery origin anomalies (CAOA)
Coronary artery fistula (CAF)
Endocardial cushion defect (ECD)
Aortopulmonary window (APW)
Anomalous pulmonary venous connection (APVC)
Cor triatriatum
Double outlet right ventricle (DORV)
Atrial septal defect (ASD)
Ventricular septal defect (VSD)
Patent ductus arteriosus (PDA)
Tetralogy of fallot (TOF)
Myxoma
Rhabdomyoma
Paraganglioma
Fibroma
Mesothelioma
Hypertrophic cardiomyopathy (HCM)
Dilated cardiomyopathy (DCM)
Restrictive cardiomyopathy (RCM)
Left ventricular noncompaction (LVNC).

Summary: This book is a state-of-the art reference that presents computed tomography (CT) and magnetic resonance (MR) cardiac imaging for the diagnosis and treatment planning of adult congenital heart disease (ACHD). It highlights the advantages of CT and MR in the management of ACHD, focusing on the complementary collaboration between these two modalities where possible. CT and MR aids in the evaluation of cardiac anatomy and function, leading to the demonstration of the full spectrum of abnormalities in complex cardiac malformations and the discovery of anomalous pathologies missed by other imaging techniques.

Contents:
1. Classification and Epidemiology
2. Embryology
3. Cardiac MRI Examination: An Overview
4. Magnetic Resonance Angiography
5. Principles of CT Imaging
Echocardiographic Imaging in Adult Congenital Heart Disease
6. Echocardiographic Imaging in Adult Congenital Heart Disease
7. Right Ventricle Outflow Tract
8. Left Ventricular Outflow Tract
9. Repaired Tetralogy of Fallot
10. Transposition of the Great Arteries
11. Univentricular Heart
12. Visceroatrial Situs in Congenital Heart Disease
13. Cardiac Shunts: ASD, VSD, PDA
14. Atrioventricular Septal Defects
15. Ebstein Anomaly
16. Hypertrophic Cardiomyopathy
17. The Right Myocardium
18. CT in Pediatric Congenital Heart Disease
19. Surgical Considerations in Adult Patients with Congenital Heart Disease
20. MRI in Repaired Congenital Heart Disease
21. Cardiac CT and MR Evaluation of the Adult Fontan Patient
22. Transcatheter Interventions in Adult Congenital Heart Disease
23. Virtual Surgery in Congenital Heart Disease
24. Aortic Arch Anomalies
25. Pulmonary Hypertension in Congenital Heart Disease
26. Congenital Thoracic Venous Anomalies
27. Coronary Artery Anomalies
28. Coronary Veins
29. Congenital Pericardial Anomalies
30. Extracardiac Complications
31. Cardiac MR in Patients with Implantable Arrhythmia Devices.

Summary: This book collates the current knowledge in cardiovascular CT and presents this in a clinically relevant and practical format appropriate for all who use the modality. The field has experienced continued rapid evolution due to advances in technology, the expanded spectrum of cardiovascular applications and significant growth in published data. As increasing numbers have access to CT scanners, Cardiac CT Imaging: Diagnosis of Cardiovascular Disease, Third Edition provides all the relevant information on the use of this modality. This extensive revision of this well-respected textbook brings the reader up-to-date with the technique, with chapters supplied by an experienced set of contributing authors and representing the full spectrum of cardiac CT. It thus represents an essential purchase for those preparing for board examinations, all training to use this modality, and those already using cardiovascular CT on a day-to-day basis who want to stay current.

Contents:
Computed Tomography: Overview
Cardiovascular Computed Tomography: Current and Future Scanning System Design
Radiation Safety: Radiation Dosimetry and CT Dose Reduction Techniques
Assessment of Cardiovascular Calcium: Interpretation, Prognostic Value, and Relationship to Lipids and Other Cardiovascular Risk Factors
Natural History and Impact of Interventions on Coronary Calcium
The Aorta and Great Vessels
Methodology for CCTA Image Acquisition
Post processing and Reconstruction Techniques for the Coronary Arteries
CTA Large Scale Trials
Coronary CT Angiography: Native Vessels
Coronary Angiography After Revascularization
Assessment of Cardiac Structure and Function by Computed Tomography Angiography
Perfusion and Delayed Enhancement Imaging
Pericardial/Myocardial Disease Processes
Computed Tomography Evaluation in Valvular Heart Disease
Assessment of Cardiac and Thoracic Masses
CT Angiography of the Peripheral Arteries
Aortic, Renal, and Carotid CT Angiography
Assessment of Pulmonary Vascular Disease
Comparative Use of Radionuclide Stress Testing, Coronary Artery Calcium Scanning, and Noninvasive Coronary Angiography for Diagnostic and Prognostic Cardiac Assessment
Cardiovascular Magnetic Resonance Imaging: Overview of Clinical Applications
Computed Tomographic Angiography in the Assessment of Congenital Heart Disease
CT Imaging: Cardiac Electrophysiology Applications
An Interventionalist's Perspective: Diagnosis of Cardiovascular Disease
CCTA: Cardiothoracic Surgery Applications
Cardiac CT in the Emergency Room
Orientation and Approach to Cardiovascular Images.

Summary: This book is an essential guide to the medical treatment of the cardiac patient and presents core principles of cardiovascular therapeutics as well as drug recommendations. Major classes of drugs are featured, including beta-blockers, ACE inhibitors, calcium antagonists, diuretics, and antiplatelet agents and unique insights into the controversies surrounding the use of specific drugs are explored, with answers given to the question: do beta blockers and diuretics really cause diabetes? Properties, dosage, side effects, potential salutary benefits, and drawbacks on virtually all commercially available cardiac drugs are examined. This revised edition is thoroughly updated and addresses the entire spectrum of heart disorders, such as hypertension, angina, myocardial infarction, heart failure, arrhythmias, cardiac arrest, and dyslipidemias. New chapters include endocrine heart diseases, management of cardiomyopathies, and newer agents. In addition, topics such as cardiac drugs in pregnancy and lactation and drug interactions are covered. Cardiac Drug Therapy, Eighth Edition, is an authoritative and clinically relevant resource for cardiologists, cardiology fellows, and internists.

Contents:
Beta-Blockers: The Cornerstone of Cardiac Drug Therapy
Beta-Blocker Controversies
Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers
ACE Inhibitor Controversies
Calcium Antagonists (Calcium Channel Blockers)
Calcium Antagonist Controversies
Diuretics
Hypertension
Hypertension Controversies
Angina
Acute Myocardial Infarction
Heart Failure
Heart Failure Controversies
Management of Cardiac Arrhythmias
Cardiac Arrest
Management of Infective Endocarditis
Dyslipidemias
Endocrine Heart Diseases
Antiplatelet Agents, Anticoagulants, Factor XA Inhibitors, Thrombin Inhibitors
Cardiac Drugs During Pregnancy and Lactation
Effects of Drug Interactions
Hallmark Clinical Trials
Management of Cardiomyopathies
Newer Agents.

Summary: In the western world, the risk of cardiovascular disease in pregnancy has grown due to the increasing age at the first pregnancy and the worldwide obesity epidemic leading to early diabetes and hypertension. As a result more women are requiring drug therapy during pregnancy and some data has shown an altered pharmacodynamic profile in pregnant women when compared to the non-pregnant population. Cardiac Drugs in Pregnancy presents up-to-date research for the treatment of cardiovascular disease during pregnancy, and discusses the most important indications of drug usage in pregnancy and postpartum. The book aims to assess the potential risk of drugs and their possible benefit against each other, making it an essential read for a wide range of health professionals involved in cardiac drug therapy in pregnancy.

Contents:
General principles and guidelines
Management of Hypertension
Management of Heart Failure pre- and postpartum
Management of coronary artery disease and Arrhythmia
Anticoagulation in Pregnancy
Obstetric drugs in the management of Cardiovascular disease.

Summary: This book offers a comprehensive review of clinical cardiac electrophysiology in a question and answer format. Chapters contain over 200 questions divided into 9 chapters, each organized by cardiac electrophysiology topic. Each question is followed by the correct answer with a detailed explanation along with references for further reading. Important concepts are highlighted and supported by over 200 illustrations and high resolution images. The book addresses a broad range of topics that are important when studying for the initial certification or recertification of the clinical cardiac electrophysiology board examination. It is also highly relevant for daily clinical practice in cardiology and cardiac electrophysiology. Topics covered in the book include: Review of basic and clinical cardiac electrophysiology principles associated with cardiac arrhythmias The evaluation and management of patients with cardiac rhythm disorders Review of pharmacologic and nonpharmacologic therapies for the treatment of arrhythmias Clinical indications, fundamental principles and electrical characteristics of implantable cardiac electronic devices such as pacemakers and defibrillators Clinical, electrocardiographic, and electrophysiologic characteristics of specific cardiac arrhythmia syndromes Cardiac Electrophysiology Board Review is a must-have resource for cardiology and cardiac electrophysiology trainees as well as attending physicians preparing for the certification or recertification examination. It may also be a useful guide for cardiologists, cardiac electrophysiologists and all clinicians who wish to further their understanding of heart rhythm disorders. .

Contents:
Basic Electrophysiology principles/ ion channels
Cardiac channelopathies
Pharmacology
Normal cardiac conduction/ Sinoatrial, atrioventricular and His-Purkinge conduction
Atrial tachycardia and atrial flutter
Atrial fibrillation
Supraventricular tachycardia
Idiopathic ventricular tachycardia
Ischemic ventricular tachycardia
Pacemaker and Defibrillator device basics
Permanent Pacemakers
Implantable cardioverter defibrillators
Syncope
Arrhythmia Syndromes. .

Summary: Cardiac Electrophysiology: From Cell to Bedside puts the latest knowledge in this subspecialty at your fingertips, giving you a well-rounded, expert grasp of every cardiac electrophysiology issue that affects your patient management. Drs. Zipes, Jalife, and a host of other world leaders in cardiac electrophysiology use a comprehensive, multidisciplinary approach to guide you through all of the most recent cardiac drugs, techniques, and technologies. Get well-rounded, expert views of every cardiac electrophysiology issue that affects your patient management from preeminent authorities in cardiology, physiology, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgery, and biomedical engineering from around the world.Visually grasp and easily absorb complex concepts through an attractive full-color design featuring color photos, tables, flow charts, ECGs, and more!

Summary: This book reflects how the concern regarding the effects of radiation exposure in patients and health personnel involved in cardiac electrophysiology (EP) has inspired new developments in cardiac electrophysiology procedures without the use of fluoroscopy. This innovative method has become a subspecialty within electrophysioloy with several EP laboratories around the world adopting an exclusive non-fluoroscopy approach. It features guidance on how to use three dimensional (3D) navigation systems, ablation energy sources and zero-fluorospic implantation of cardiac electronic devices. The potential complications and associated preventative methods with utilising RFCA are also described. Cardiac Electrophysiology Without Fluoroscopy offers a thorough description of the technique correlated to the performance of EP procedure without the use of radiation, and provides a valuable resource for those seeking a practically applicable guide on how to perform cardiac EP without fluoroscopy, including practising and trainee electrophysiologists, cardiac imagers, general cardiologists and emergency medicine physicians.

Contents:
Clinical Studies of a purely 3D Navigation in Interventional Managements of Tachyarrhythmia
Radiation exposure and safety for the electrophysiologist
Ablation Energy Sources-Principles and Utility in Ablation without Fluoroscopy
3D mapping and reduction in radiation exposure
Catheter Placement and Model reconstruction
Learning curve for zero-fluoroscopic procedure
Atrioventricular Nodal Reentrant Tachycardia (AVNRT) with zero-fluoroscopic procedure
AV Nodal re-entrant tachycardia ablation without fluoroscopy
Non-Fluoroscopic Catheter Ablation of Accessory Pathways
Focal atrial tachycardia
Ablation of atrial flutter with zero fluoroscopy approach
Non-Fluoroscopic Catheter Ablation of Atrial Fibrillation
Non-Fluoroscopic Catheter Ablation of Idiopathic Ventricular Arrhythmias
Ventricular Tachycardia with Structural Heart Disease
Reduction on radiation exposure in pediatric population undergoing ablation procedures
Complications of RFCA and Prevention Method
Safety of zero-fluroscopic procedure during pregnancy
Cost optimization when using 3-D mapping systems for a non fluoro EP lab
Zero-fluoroscopic implantation of cardiac electronic Device
Cardiac Resynchronization Therapy (CRT) guided by 3D mapping system
Transesophageal Electrophysiological Study without fluoroscopy.

Summary: This book is primarily for pediatric and adult emergency room physicians, primary care providers, hospitalists, and nurses. It will also be useful for critical care specialists, cardiologists and trainees at all levels. Cardiac Emergencies in Children describes the pathophysiology of a diverse group of congenital and acquired heart conditions and presents a therapeutic rationale for treating children presenting with these conditions under life-threatening conditions. The book discusses the effects of surgery on hemodynamics and how to manage these effects. Also described are the daily challenges faced by physicians, including identifying a child with heart disease, interpreting chest radiographs, ECGs, and laboratory findings, and beginning appropriate therapies.

Contents:
Part I. Control of Energy Metabolism
A Primer on Carbohydrate Metabolism in the Heart / Heinrich Taegtmeyer
Lipoproteins: A Source of Cardiac Lipids / Konstantinos Drosatos and Ira J. Goldberg
Role of Lipoprotein Lipase in Fatty Acid Delivery to the Heart / Andrea Wan and Brian Rodrigues
Control of Myocardial Fatty Acid Uptake / Jan F. C. Glatz and Joost J. F. P. Luiken
Cardiac Energy Metabolism in Heart Failure Associated with Obesity and Diabetes / Gary D. Lopaschuk
Transcriptional Control of Mitochondrial Biogenesis and Maturation / Rick B. Vega , Teresa C. Leone , and Daniel P. Kelly
Relationship Between Substrate Metabolism and Cardiac Efficiency / Ellen Aasum
Acetylation in the Control of Mitochondrial Metabolism and Integrity / Michael N. Sack
Part II. Alteration in Energy Metabolism
Adrenergic Control of Cardiac Fatty Acid Oxidation in Diabetes / Vijay Sharma and John H. McNeill
The Myocardial Creatine Kinase System in the Normal, Ischaemic and Failing Heart / Craig A. Lygate and Stefan Neubauer
Fuel Metabolism Plasticity in Pathological Cardiac Hypertrophy and Failure / Stephen C. Kolwicz and Rong Tian
Defects in Mitochondrial Oxidative Phosphorylation in Hearts Subjected to Ischemia-Reperfusion Injury / Vijayan Elimban , Paramjit S. Tappia , and Naranjan S. Dhalla
The Role of AMPK in the Control of Cardiac Hypertrophy / Nikole J. Byrne, Miranda M. Sung, and Jason R. B. Dyck
The Role of Incomplete Fatty Acid β-Oxidation in the Development of Cardiac Insulin Resistance / John R. Ussher
Part III. Optimization of Energy Metabolism
Metabolic Therapy for the Ischemic Heart / Giacinta Guarini , Alda Huqi , and Mario Marzilli
Inhibition of Fatty Acid Oxidation to Treat Heart Failure in Patients / Rui Yan , Jin Wei , and Dengfeng Gao
Cardiac Metabolic Protection for the Newborn Heart / J. Carter Ralphe and Thomas D. Scholz
Targeting Transcriptional Control of Fatty Acid Oxidation to Treat Heart Disease / Michael A. Portman and Aaron K. Olson.

Summary: This book on cardiac extracellular matrix (ECM) features three sections, Fundamental Science, Pre-Clinical and Translational Science, and Clinical Applications. In the Fundamental Science section, we will cover the spectrum of basic ECM science from ECM's role in development, biomechanical properties, cardiac ECM influence of cardiomyocyte biology, pathophysiology of ECM in heart disease, and ECM in tissue engineering. Section two, Preclinical and Translational Science, will discuss cardiac ECM technologies in the clinical pipeline including approaches to ECM as a therapeutic, animal models of cardiac research, tracking and imaging methods of cardiac ECM, and cGMP manufacturing and regulatory considerations for ECM based therapeutics. Finally, the third section, Clinical Applications, will highlight the clinical experience around cardiac ECM including therapeutic strategies targeting scar tissue in the heart, clinical trial design and regulatory considerations, current human clinical trials in cardiovascular medicine and the role of pharmaceutical and biotech companies in the commercialization of ECM technologies for cardiovascular indications. This book provides a comprehensive review for basic and translational researchers as well as clinical practitioners and those involved in commercialization, regulatory and entrepreneurial activities.

Contents:
Biomechanical properties and mechanobiology of cardiac ECM / Michael Nguyen-Truong, Zhijie Wang
Imaging the cardiac extracellular matrix / Michael A. Pinkert, Rebecca A. Hortensius, Brenda M. Ogle, Kevin W. Eliceiri
Animal models and cardiac extracellular matrix research / Timothy A. Hacker
Applications of cardiac extracellular matrix in tissue engineering and regenerative medicine / Mark C. Daley, Spencer L. Fenn, Lauren D. Black III
Whole cardiac tissue bioscaffolds / Karis R. Tang-Quan, Nicole A. Mehta, Luiz C. Sampaio, Doris A. Taylor
Natural sources of extracellular matrix for cardiac repair / Keith L. Spinali, Eric G. Schmuck
Cardiac extracellular matrix modification as a therapeutic approach / Mikayla L. Hall, Brenda M. Ogle
Extracellular matrix for myocardial repair / Jenna L. Dziki, Stephen F. Badylak
Role of extracellular matrix in cardiac cellular therapies / Peiman Hematti
Regulation of regenerative medicine products / Adrian P. Gee
Clinical trial design for investigational cardio-regenerative therapy / Amish N. Raval
Regenerative medicine venturing at the university-industry boundary: implications for institutions, entrepreneurs, and industry / Adam J. Bock, David Johnson.

Contents:
Cardiac fibrosis and heart failure-- cause or effect?
Fibroblast activation in the infarcted myocardium
Mechanical and matrix regulation of valvular fibrosis
Bone marrow-derived progenitor cells, micro-RNA, and fibrosis
The stressful life of cardiac myofibroblasts
Pathogenic origins of fibrosis in the hypertensive heart disease that accompnaies aldosternoism
Embryological origin of valve progenitor cells
Diverse cellular origin of valve progenitor cells
Diverse cellular origins of cardiac fibroblasts
Non-canonical regulation of TGF-β1 signaling: a role for Ski/Sno and YAP/TAZ
Molecular mechanisms of smooth muscle and fibroblast phenotype conversions in the failing heart
Current and future strategies for the diagnosis and treatment of cardiac fibrosis
Remodelling of the cardiac extracellular matrix: role of collagen degradation and accumulation in pathogenesis of heart failure
Matrix metalloproteinase 9 (MMP-9)
Collagen processing and its role in fibrosis
Mechanisms of cardiac fibrosis and heart failure
Mathematical simulations of sphingosine-1-phosphate actions on mammalian ventricular myofibroblasts and myocytes
Extracellular matrix and cardiac disease: surgical and scientific perspectives
The role or neurohumoral activation in cardiac fibrosis and heart failure
Natriuretic peptides: critical regulators of cardiac fibroblasts and the extracellular matrix in the heart
Cardiac tissue engineering for the treatment of heart failure post-infarction
Mechanisms in cardiac valve failure and the development of tissue engineered heart valves
Index.

Summary: "The Core Review Series will be the first and only reference specifically designed for the new exam. This title will consist of approximately 300 questions, in a format similar to the exam with image-rich MCQs. Answers to the questions will be discussed in a concise manner along with explanations of each choice followed by relevant references. Cardiac Imaging: A Core Review will cover questions ranging from basic imaging, normal anatomy, all diseases relative to cardiac imaging, all modalities, and postoperative appearances of devices. Key Features Image-rich review text with 300 questions-includes answers and explanations. On average, each question will have 1-2 corresponding images. Bundled with an Inkling version for interactive and mobile review. High-yield tables embedded in the answers. Answers to the questions with explanations on why a particular answer choice is correct and why the other choices are incorrect"-- Provided by publisher.

Summary: "The second edition of the Cardiac Imaging: A Core Review builds on the success of the first edition by covering the essential aspects of cardiac imaging in a manner that serves as a guide for residents to assess their knowledge and review the material in a format that is like the ABR core examination"-- Provided by publisher.

Contents:
Basics of Imaging: Radiography, CT, and MR / Nancy Pham, MD, Joe Y. Hsu, MD, Amar B. Shah, MD, MPA, Jean Jeudy, MD, and Sachin Malik, MD
Normal Anatomy, Including Variants, Encountered on Radiography, CT, and MR./ Joe Y. Hsu, MD, Amar B. Shah, MD, MPA, and Sachin Malik, MD
Physiologic Aspects of Cardiac Imaging / Amar B. Shah, MD, MPA and Jean Jeudy, MD
Ischemic Heart Disease / Brian Pogatchnik, MD, Amar B. Shah, MD, MPA, and Sachin Malik, MD
Cardiomyopathy / Jean Jeudy, MD and Sachin Malik, MD
Cardiac Masses / Joe Y. Hsu, MD and Jean Jeudy, MD
Valvular Disease / Jean Jeudy, MD and Sachin Malik, MD
Pericardial Disease / Alan Ropp, MD, MS, Amar B. Shah, MD, MPA, and Jean Jeudy, MD
Congenital Heart Disease / Joe Y. Hsu, MD and Jean Jeudy, MD
Acquired Disease of the Thoracic Aorta and Great Vessels / Joe Y. Hsu, MD, Amar B. Shah, MD, MPA, and Jean Jeudy, MD
Devices and Postoperative Appearance / Jody Shen, MD, Joe Y. Hsu, MD, Amar B. Shah, MD, MPA, Jean Jeudy, MD, and Sachin Malik, MD.

Contents:
Introduction to cardiac imaging / Lawrence M. Boxt and Suhny Abbara
Echocardiography / Kaitlyn My-Tu Lam and Mary Etta E. King
Cardiac magnetic resonance imaging / Amgad N. Makaryus and Lawrence M. Boxt
Cardiac computed tomography / Amgad N. Makaryus and Lawrence M. Boxt
Coronary heart disease / Nagina Malguria and Suhny Abbara
Myocardium, pericardium, and cardiac tumor / Nagina Malguria, Stephen W. Miller, and Suhny Abbara
Valvular heart disease / Suhny Abbara and Nagina Malguria
Thoracic aortic disease / Steven L. Hsu, Sanjeeva Kalva, John G. Santilli, and Stephen W. Miller
Congenital heart disease / B. Kelly Han, Stephen W. Miller, and Lawrence M. Boxt.

Contents:
Echocardiography-Physics basics
Views
Chamber quantification
Valves: AS, AR, MS, MR, TS, TR, PS, PR subchapters
Artificial valves basics, AS, AR, MS, MR, TS, TR, PS, PR
Diastology
Pericardial disease
Cardiac Masses
Non-invasive catheterization
Basic cardiac anomalies
Ischemic heart disease
CHF
Cardiomyopathies
Systemic diseases
Aortic disease
Basics of bubble and contrast studies
SPECT-Basics of SPECT Radioisotopes
Ischemia work up
Viability work up
CT- Technique
Indications
Sample images
MRI-Basic technique
Indications
Function, Viability
Masses, CMP, scar, amyloid, HCM images
Pericardium: inflammation, constriction vs. restriction.

Summary: "Using a multidisciplinary, team-oriented approach, this unique title expertly covers all the latest approaches to the assessment, diagnosis, and treatment of patients with critical cardiac illness. Led by Dr David L. Brown, a stellar team of authoritative writers guides you through cardiac pathophysiology, disease states presenting in the CICU, and state-of-the-art advanced diagnosis and therapeutic techniques. A visually appealing format, new chapters, and thorough updates ensure that you stay on the cutting edge of this rapidly advancing field"--Publisher's description.

Contents:
Section I. Introduction. Evolution of the coronary care unit: past, present, and future
Ethical issues of care
Physical examination
Section II. Scientific foundation of cardiac intensive care. The role of the cardiovascular system in coupling the external environment to cellular respiration
Regulation of cardiac output
Coronary physiology and pathophysiology
Pathophysiology of acute coronary syndromes: plaque rupture and atherothrombosis
Regulation of hemostasis and thrombosis
Section III. Coronary artery disease. Acute myocardial infarction
Diagnosis of acute myocardial infarction
Use of the electrocardiogram in acute myocardial infarction
Reperfusion therapies for acute ST- elevation myocardial infarction
Adjunctive pharmacologic therapies in acute myocardial infarction
Complications of acute myocardial infarction
Post-myocardial infarction cardiogenic shock
Right ventricular infarction
Mechanical complications of acute myocardial infarction
Supraventricular and ventricular arrhythmias in acute myocardial infarction
Conduction disturbances in acute myocardial infarction
Complications of percutaneous interventional procedures
Section IV. Noncoronary diseases: diagnosis and management. Acute heart failure and pulmonary edema
Acute fulminant myocarditis
Stress (Takotsubo) cardiomyopathy
Distributive shock
Cardiorenal syndrome
Sudden cardiac death
Diagnosis and treatment of ventricular tachycardia
Diagnosis and treatment of unstable supraventricular tachycardia
Acute presentations of valvular heart disease
Hypertensive emergencies
Acute aortic syndromes: diagnosis and management
Acute pericardial disease
Acute respiratory failure
Massive acute pulmonary embolism
Pulmonary hypertension
Hemodynamically unstable presentations of congenital heart disease in adults
Overdose of cardiotoxic drugs
Section V. Pharmacologic agents in the cardiac intensive care unit. Anticoagulation: antithrombin therapy
Anti-platelet therapy
Inotropic and vasoactive agents
Intensive diuresis and ultrafiltration
Antiarrhythmic electrophysiology and pharmacotherapy
Analgesics, tranquilizers, and sedatives
Pharmacologic interactions
Section VI. Advanced diagnostic and therapeutic techniques: indications and technical considerations. Central venous access procedures
Temporary pacing
Pericardiocentesis
Invasive hemodynamic monitoring
Temporary mechanical circulatory support devices
Ventricular assist device therapy in advanced heart failure
Heart transplantation for advanced heart failure
Emergency airway management
Mechanical ventilation
Cardiopulmonary cerebral resuscitation after cardiac arrest
Palliative care.

Summary: This book presents the main cardiac pathologies, providing a helpful guide featuring clinical cases and electronic supplementary material. There are several systematic books on cardiac magnetic resonance, which approach the different pathologies and related pathophysiology in a general manner, and these are useful for readers at an early stage in their medical careers. However, when it comes to individual patients (during the acquisition of images and reporting activities) there is no book providing operative protocols or systematic descriptions of details to look for. In the eight chapters (Cardiomyopathies, Myocarditis, Ischemic Heart Disease, Valvular Heart Diseases, Cardiac Masses, Pericardial Diseases, Congenital Heart Disease, and Miscellanea), the individual pathology is illustrated with a clinical case. The cases are divided into four sections: An introduction with a short medical history and the purpose of the diagnostic CMR A detailed CMR acquisition protocol CMR images, indicating purpose, method, analysis and meaning of the image, as well as videos. Concluding paragraph with the final diagnosis reached on the basis of the findings obtained in each image This book, collecting one hundred one clinical cases covering a broad spectrum of cardiac diseases, is an invaluable tool for radiologists and cardiologists.

Contents:
Chapter 1 Cardiomyopathies
Chapter 2 Myocarditis
Chapter 3 Ischemic Heart disease
Chapter 4 Valvular Heart Diseases
Chapter 5 Cardiac Masses
Chapter 6 Pericardial Diseases
Chapter 7 Congenital Heart Disease
Chapter 8 Miscellanea.

Contents:
1. Introduction. The specificity of geriatric cardiology
2. Epidemiology of heart disease in the elderly
3. Molecular mechanisms of cardiovascular aging
4. Frailty and heart disease
5. Evidence based medicine and evidence biased medicine in geriatric cardiology. From the trial to the real word
6. Polypharmacy
7. Syncope and Unexplained Falls in the elderly.-- 8. Hypertension in the oldest old, beyond the guidelines.-- 9. New challenges in aortic stenosis in the elderly: from epidemiology to TAVI.-- 10. The aging kidney and cardiovascular disease
11. Risk assessment in cardiac and non-cardiac surgery in the older patient
12. Atrial fibrillation in the elderly
13. Cardiac devices in the elderly
14. Management of acute coronary syndromes in the elderly
15. Cardiac surgery in the oldest old.

Contents:
Introduction
Physiopathology and toxic drugs heart effects
Radiotherapy heart effects
Cardiac imaging technology in cardio-oncology
Evaluation of the oncologic patient before, during and after chemotherapy
What drug/what possible complication
What cancer type/what possible drug
what cancer/what possible complication
Management (prevention/diagnosis/evaluation/therapy) of hypertension
Management (prevention/diagnosis/evaluation/therapy) of coronary disease and thrombo-embolic complication
Management (prevention/diagnosis/evaluation/therapy) of arrhythmic complication
Management (prevention/diagnosis/evaluation/therapy) of systolic dysfunction.

Summary: "In many ways, this textbook mirrors the development of the field of cardiac device placement and management. The original version of this text was written by Drs. Seymour Furman, David Hayes, and David Holmes, pioneers and founders of interventional electrophysiology and device management. The goals of the present text remain similar to the original intent, that is, to provide a relatable, practical approach without ignoring the rigors of fundamental principles while retaining the flexibility in the professional's mind to embrace new technology. Updates on resynchronization therapy, subcutaneous defibrillators, leadless devices, and improvements in lead extraction have been included in this text. We continue to stay away from an encyclopedic approach but rather focus on a usable, practical, and intuitive approach for problem solving in the day-to-day practice of a cardiac electrophysiology professional. As with all prior editions, we owe a great debt of gratitude to all the contributors who have tirelessly updated their sections and have done multiple revisions. We also have to thank our patients and nursing staff who provide us with material to allow us to learn to a point where we can try and teach troubleshooting approaches, etc. We received tremendous support from various device manufacturers, their engineers, and their published data material. These include assistance from Biotronik, Boston Scientific, Medtronic, and Abbott Medical"-- Provided by publisher.

Contents:
Front Matter
Pacing and Defibrillation / T Jared Bunch, Suraj Kapa, David L Hayes, Charles D Swerdlow, Samuel J Asirvatham, Paul A Friedman
Hemodynamics of Cardiac Pacing / Christopher V DeSimone, Joanna Gullickson, David L Hayes, Paul A Friedman, Samuel J Asirvatham
Indications for Pacemakers, Implantable Cardioverter-Defibrillators, and Cardiac Resynchronization Therapy / Krishna Kancharla, David L Hayes, Samuel J Asirvatham, Paul A Friedman
Choosing the Device Generator and Leads / Christopher J McLeod, Anca Chiriac, Malini Madhavan, David L Hayes, Paul A Friedman, Samuel J Asirvatham
Implanting and Extracting Cardiac Devices / Siva K Mulpuru, Malini Madhavan, Samuel J Asirvatham, Matthew J Swale, David L Hayes, Paul A Friedman
Implant-Related Complications / Niyada Naksuk, David L Hayes, Paul A Friedman, Samuel J Asirvatham
Timing Cycles / David L Hayes, Paul J Wang, Samuel J Asirvatham, Paul A Friedman
Programming / Paul A Friedman, Charles D Swerdlow, Samuel J Asirvatham, David L Hayes, Avi Sabbag
Sensor Technology for Rate-Adaptive Pacing and Hemodynamic Optimization / Krishna Kancharla, David L Hayes, Samuel J Asirvatham, Paul A Friedman
Troubleshooting / Charles D Swerdlow, Paul A Friedman, Samuel J Asirvatham, David L Hayes
Radiography of Implantable Devices / David L Hayes, Paul A Friedman, Samuel J Asirvatham
Electromagnetic Interference / Subir Bhatia, Alan Sugrue, David L Hayes, Paul A Friedman, Samuel J Asirvatham
Follow-up / Alan Sugrue, Vaibhav R Vaidya, David L Hayes, Michael Glikson, Paul A Friedman, Samuel J Asirvatham
Index