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  • Book
    edited by Eric C. Schirmer, Jose I. de las Heras.
    Summary: Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology, but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis, and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers, and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer.

    Contents:
    Part I. History and use of the nuclear envelope in cancer prognosis
    Part II. The nuclear envelope in cell cycle regulation and signaling
    Part III. Nuclear envelope regulation of the genome
    Part IV. Functions of the NPC in cancer
    Part V. The nuclear envelope in DNA damage and stress responses
    Part VI. Towards a molecular explanation of prognostic links to the nuclear envelope
    Erratum to
    Index.
    Digital Access Springer 2014