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  • Book
    Priya Hays, editors.
    Summary: This book presents the clinical scope of cancer immunotherapeutic agents for solid tumors and Hematologic malignancies, elaborates on the scientific details of their modes of action, and presents the impact of these agents on oncology, patients and the broader healthcare system. At present, cancer immunotherapies fall broadly into three categories: immune checkpoint inhibitors (ICIs), adoptive T cell therapies, and cancer vaccines which have distinct mechanisms of action. Immune checkpoint inhibitors rely upon disrupting tumor antigen recognition as self by the immune system through inhibition of checkpoint molecules. Adoptive T cell therapies involve the engineering of T cells ex vivo to target and destroy tumor cells. The first part of this book will provide an overview of the discovery and mechanistic details of the technology. The second part will be devoted to elaborating on the clinical outcomes, successes and limitations for specific tumor subtypes, which includes both solid tumors and hematologic malignances for both pediatric and adult populations. As such, the book offers a valuable resource for oncologists, hematologists, and all those seeking an up-to-date overview of cancer immunotherapies.

    Contents:
    Development of Cancer Immunotherapies
    Melanoma
    Engaging pattern recognition receptors in solid tumors to generate systemic anti-tumor immunity
    Allogeneic tumor antigen-specific T cells for broadly applicable adoptive cell therapy of cancer
    Chimeric Antigen Receptor (CAR) T Cell Therapy for Glioblastoma
    Lag3: From Bench to Bedside
    Immunotherapy in Genitourinary Malignancy: evolution in revolution or revolution in evolution
    Immune-based therapeutic interventions for Acute Myeloid Leukemia.-Off-the-shelf chimeric antigen receptor immune cells from human pluripotent stem cells
    The single-cell level perspective of the tumor microenvironment and its remodeling by CAR-T cells
    Clinical Development and Therapeutic Applications of Bispecific Antibodies for Hematological Malignancies.
    Digital Access Springer 2022
    Print Access Request
    Location
    Version
    Call Number
    Items
    Books: General Collection (Downstairs)
    2022
    RC271.I45 C36 2022
    1