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  • Book
    Mansi Arora, Deepak Kaul.
    Summary: In the last decade, researchers working in the field of cancer biology have shifted their focus from genetic defects to epigenetic dysregulation, especially that of non-coding RNAs (ncRNAs). This book encompasses a comprehensive review of the transcriptional landscape of the cell and its involvement in the cancer pathophysiology. The first two chapters elucidate the basics of biosynthesis, mechanism of action and modulation of the epigenetic regulation of gene expression by coding as well as non-coding RNAs. The third chapter discusses the aberrant expression of the cellular RNome in the cancer cells and highlights its role in the orchestration of processes involved in evolution as well as the sustenance of cancer cells. The fourth chapter describes the recent advances in the field of translating the transcriptome into diagnostic/prognostic biomarkers and as targets for novel anti-cancer therapies. The final chapter then reviews the emerging experimental approaches to screen, identify and explore the functions of ncRNAs. Providing valuable insights into the field of RNome in the context of cancer, this book is helpful to students, researchers and clinicians.

    Contents:
    1. Section 1. RNome: Evolution and nature
    Chapter. 1.1. RNA world hypothesis
    Chapter. 1.2. Various classes of RNAs (coding as well non-coding), their biosynthesis and basic functions
    2. Section 2. Cellular RNome: Chromatin dynamics
    Chapter. 2.1. Chromatin modifications & transcription
    Chapter. 2.2. RNA modifications and epitranscriptomics
    Chapter. 2.3. Cellular RNome: Contribution of non-coding RNA
    3. Section 3. Cancer RNome: Evolution and Sustenance.(How is cancer RNome different from RNome of healthy cell? How does the cancer RNome regulate the evolution as well as the sustenance of cancer?)
    Chapter. 3.1. Genome instability and mutation
    Chapter. 3.2. Tumor-promoting inflammation
    Chapter. 3.3. DNA methylation addiction
    Chapter. 3.4. Oncoviruses
    Chapter. 3.5. Sustained proliferative signaling
    Chapter. 3.6. Evasion of growth suppressors
    Chapter. 3.7. Replicative immortality
    Chapter. 3.8. Resisting Cell death
    Chapter. 3.9. Invasion and metastasis
    Chapter. 3.10. Angiogenesis induction.-Chapter. 3.11. Deregulated cellular energetics/Molecular sweet tooth
    Chapter. 3.12. Tumor Immune-evasion
    Chapter. 3.13. Cancer stem cells and tumor cell plasticity
    4. Section 4. Cancer RNome: Therapeutic implications(Translational implications of the cancer RNome). Chapter. 4.1. RNAs as diagnostic/prognostic biomarkers
    Chapter. 4.2. RNAs in cancer therapy & chemo-resistance.
    Digital Access Springer 2018