BookSusan C. Frost, Robert McKenna, editors.
Summary: The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification.
Contents:
Overview of the Carbonic Anhydrase Field
Physiological Functions of the Alpha Class of Carbonic Anhydrases
Catalytic Mechanism of [alpha]-Class Carbonic Anhydrases: CO2 Hydration and Proton Transfer
Structure and Catalytic Mechanism of b-Carbonic Anhydrases
Prokaryotic Carbonic Anhydrases of Earth?s Environment
Carboxysomal Carbonic Anhydrases
Carbonic Anhydrases and their Interplay with Acid/base-coupled Membrane Transporters
Carbonic Anhydrase Related Proteins: Molecular Biology and Evolution
Membrane Associated Carbonic Anhydrase IV (CA IV): A Personal and Historical Perspective
Carbonic Anhydrase Expression in Kidney and Renal Cancer: Implications for Diagnosis and Treatment
Carbonic Anhydrase IX: Regulation and Role in Cancer
Carbonic Anhydrase IX as an Imaging and Therapeutic Target for Tumors and Metastases
Carbonic Anhydrase IX (CAIX) as a Mediator of Hypoxia-induced Stress Response in Cancer Cells
Carbonic Anhydrases and Brain pH in the Control of Neruronal Excitability
Carbonic Anhydrase Inhibitors: Drug Design
Natural Products that Inhibit Carbonic Anhydrases
Glaucoma and the Application of Carbonic Anhydrase Inhibitors
Carbonic Anhydrase Inhibitors and High Altitude Illnesses
Thermal-Stable Carbonic Anhydrases: A Structural Overview
Carbonic Anhydrases in Industrial Applications.