Books

Section 1: Basic Processes at the Cellular Levels -- Arginine uptake by cells -- L-arginine and the expression of HSP70 and p-53 proteins -- AMP-activated protein kinase and L-arginine -- Amidine-based compounds affecting arginine metabolism -- Oxy- and sulfoanalogues of L-arginine -- Regulation of expression and activity of L-arginine transporters by nutrients and hormones: A focus in transcriptional mechanisms regulated by glucose and insulin -- Arginine, pancreatic beta cell function and diabetes: mechanisms of stimulated insulin release and pathways of metabolism -- Erythrocytes by-products of arginine catabolism -- Section 2: Arginine Metabolism and Functions -- Arginine synthesis from enteral proline -- Arginine and macrophages: role in classical and alternative activation -- Arginine and TNF alpha production in macrophages: a focus on metabolism, ageing, metabolic syndrome and type 2 diabetes -- Arginine metabolism impairment during sepsis and diseases: causes and consequences -- Use of arginine with Growth Hormone Releasing Hormone (GHRH) and the endocrine response -- Serum arginase in healthy subjects and nitric oxide -- Section 3: Arginine Status in Cells Related to Organ Damage and Disease -- Protein Arginine Methylation of RNA-binding Proteins and Their Impact on Human Diseases -- DNA-arginine adducts and implications in disease -- Homoarginine and L-arginine: Glycine amidinotransferase in stroke -- The L-arginine/asymmetric dimethylarginine (ADMA) ratio in health and disease: an overview -- Arginine and its transporters in colorectal cancer -- Arginine Uptake and Its Role in the Survival of Breast Cancer Cells -- Section 4: Arginine Status and Use in Healthy Individuals -- Arginine production during pregnancy -- L-arginine in the uterus and placenta and during gestation in mammals -- Oral L-arginine supplementation in young males: endocrinology, metabolic, and physiological responses at rest and during exercise -- Metabolic precursors of L-Arginine supplementation in sport: a focus on L-Citrulline and L-Ornithine -- Section 5: Arginine and Diseases of the Gastrointestinal Tract -- Arginine and its use in ameliorating Cryptosporidium parvum infection in undernourished children -- Arginine and Inflammatory Bowel Disease (IBD) -- Dietary L-arginine and intestinal recovery -- Enteral and parenteral arginine supplementation in intestinal ischemia and reperfusion injury -- Mucosal Protection by Arginine in the Upper Gastrointestinal Tract -- Enteral L-arginine and necrotizing enterocolitis -- Section 6: Therapeutic uses of Arginine: Diabetes, Obesity and Cardiovascular Diseases -- L-arginine usage in Type I diabetes: From the autoimmune event to human dietary supplementation -- Oral l-arginine supplementation and glucose metabolism and vascular function -- Arginine enriched apples and diabetic control -- Beneficial impact of cod protein, arginine and other amino acids on insulin sensitivity -- Obese subjects and supplemental L-arginine -- Mitochondrial cardiomyopathy and usage of L-arginine -- Arginine Measurement and Concentrations in Hypertension and other Cardiovascular Disease -- L-Arginine and cardiovascular disease -- Arginine therapy in sickle cell disease -- Section 7: Therapeutic Uses of Arginine: Cancer, Wound Healing and Infectious Disease -- Role of arginine in surgical patients with head and neck cancer -- Arginine-Incorporated Albumin Mesospheres: A Drug Delivery System for Cancer Therapy -- Use of L-arginine and glycine supplementation to reduce radiotherapy damage -- Arginine in Cancer Therapy -- Mechanisms of Arginine-Auxotrophic Response and Their Cancer Therapeutic Implications -- The role of arginine in wound healing -- L-arginine and bacterial translocation: implications for health -- L-arginine in Pulmonary Tuberculosis -- Arginine in Health and Disease: Recommended Resources and Further Reading.

Jahren has built three laboratories in which she's studied trees, flowers, seeds, and soil. She tells about her childhood in rural Minnesota with an uncompromising mother and a father who encouraged hours of play in his classroom's labs; about how she found a sanctuary in science, and the disappointments, triumphs and exhilarating discoveries of scientific work. Yet at the core of this book is the story of a relationship Jahren forged with Bill, who becomes her lab partner and best friend. Their sometimes rogue adventures in science take them over the Atlantic to the ever-light skies of the North Pole and to tropical Hawaii, where she and her lab currently make their home.

An illuminating debut memoir of a woman in science; a moving portrait of a longtime friendship; and a stunningly fresh look at plants that will forever change how you see the natural world. Acclaimed scientist Hope Jahren has built three laboratories in which she's studied trees, flowers, seeds, and soil. Her first book is a revelatory treatise on plant life but it is also so much more. "Lab Girl" is a book about work, love, and the mountains that can be moved when those two things come together. It is told through Jahren's remarkable stories: about her childhood in rural Minnesota with an uncompromising mother and a father who encouraged hours of play in his classroom's labs; about how she found a sanctuary in science, and learned to perform lab work done with both the heart and the hands; and about the inevitable disappointments, but also the triumphs and exhilarating discoveries, of scientific work. Yet at the core of this book is the story of a relationship Jahren forged with a brilliant, wounded man named Bill, who becomes her lab partner and best friend. Their sometimes rogue adventures in science take them from the Midwest across the United States and back again, over the Atlantic to the ever-light skies of the North Pole and to tropical Hawaii, where she and her lab currently make their home. Jahren's probing look at plants, her astonishing tenacity of spirit, and her acute insights on nature enliven every page of this extraordinary book. "Lab Girl" opens your eyes to the beautiful, sophisticated mechanisms within every leaf, blade of grass, and flower petal. Here is an eloquent demonstration of what can happen when you find the stamina, passion, and sense of sacrifice needed to make a life out of what you truly love, as you discover along the way the person you were meant to be. -- Publisher description.

Laboratory Animal Welfare provides a comprehensive, up-to-date look into the new science of animal welfare within laboratory research. Animals specifically considered include rodents, cats and dogs, nonhuman primates, agricultural animals, avian animals and aquatic animals. The book examines the impact of experiment design and environment on animal welfare, as well as emergency situations and euthanasia practices. Readers will benefit from a review of regulations and policy guidelines concerning lab animal use, as well as information on assessing animal welfare. With discussions of the history and ethics of animals in research, and a debate on contemporary and international issues, this book is a go-to resource for laboratory animal welfare.

1. Same principles, some differences / Javier Guillen and Patri Vergara -- 2. Oversight of research animal welfare in the United States / John F. Bradfield, B. Taylor Bennett, and Cynthia S. Gillett -- 3. Canada's oversight of animal use in science / Gilly Griffin and Michael Baar -- 4. Laboratory animal science legislation in Latin America / Ekaterina Akimovna Botovchenco Rivera [and three others] -- 5. The European framework on research animal welfare regulations and guidelines / Javier Guillen [and three others] -- 6. Israeli legislation and regulation on the use of animals in biological and medical research / Rony Kalman [and three others] -- 7. Animal experimentation in Africa : legislation and guidelines / Amanda R. Hau [and five others] -- 8. Laws, regulations, and guidelines shaping research animal care and use in India / Syed SYH Qadri and Christian E. Newcomer -- 9. Oversight of animal research in China / Kathryn Bayne and Jianfei Wang -- 10. Laws, regulations, guidelines, and principles pertaining to laboratory animals in Far East Asia / Tsutomu Miki-Kurosawa, Jae Hak Park, and Chou-Chu Hong -- 11. Laws, regulations, guidelines, and principles pertaining to laboratory animals in Southeast Asia / Montip Gettayacamin [and eight others] -- 12. Laboratory animals regulations and recommendations for global collaborative research : Australia and New Zealand / John Schofield [and three others].

"This laboratory manual is a compilation of years of work developing the neurologic and geriatric rehabilitation laboratory course at the Ohio State University. It is a constantly evolving course, but we wanted to capture the essence of the course and share it so that other instructors could utilize the resources developed over the years. This manual is designed to be used in conjunction with the textbook Neurologic Rehabilitation: Neuroscience and Neuroplasticity in Physical Therapy Practice but could be used with other neurologic rehabilitation textbooks."--Preface

v. 1. Clinical chemistry -- v. 2. Hematology and blood banking. Medical microbiology, serology, and immunology -- v. 3. Special techniques -- v. 4. Body fluids, including urine. Cytology and cytogenetics. Laboratory management and function -- v. [5] Index.

Structural dynamics of nucleic acids by single-molecule FRET / Asger Christian Krüger, Lasse Lava Hildebrandt, Sofie Louise Kragh, Victoria Birkedal -- Visualizing the location and the dynamics of gene expression in living animals through bioluminescence imaging / Xiaojuan Chen -- Quality control protocol for confocal system / Anda Cornea -- Electron microscopy of bone / V. Everts, K.A. Hoeben -- Immunostaining : detection of signaling protein location in tissues, cells and subcellular compartments / Biswanath Maity, David Sheff, Rory A. Fisher -- Bimolecular fluorescence complementation (BiFC) analysis of protein-protein interaction : how to calculate signal-to-noise ratio / Yutaka Kodama, Chang-Deng Hu -- Immunohistochemical detection of neuropeptides/transmitters in mammalian brain / Lothar Jennes -- Intravital imaging of autoreactive T. cells in living animals / Naoto Kawakami, Ingo Bartholomäus, Marija Pesic, Nikolaos I. Kyratsous -- Genetically encoded click chemistry for single-molecule FRET of proteins / Swati Tyagi, Edward A. Lemke -- High-throughput methods for the detection of protein overexpression using fluorescence markers / Mads Gabrielsen, Andrew J. Roe, Karen McLuskey -- Correlative microscopy / Alexander A. Mironov, Galina V. Beznoussenko -- Stereology of the lung / Jan Philipp Schneider, Matthias Ochs -- Quantitative 3D cell-based assay performed with cellular spheroids and fluorescence microscopy / Nariman Ansari, Stefanie Müller, Ernst H.K. Stelzer, Francesco Pampaloni -- Optimizing fluorescence excitation and detection for intravital two-photon microscopy / Dan Suan, Henry R. Hampton, Michio Tomura, Osami Kanagawa, Tatyana Chtanova, Tri Giang Phan -- Two-dimensional crystallization by dialysis for structural studies of membrane proteins by the cryo-EM method electron crystallography / Matthew C. Johnson, Ingeborg Schmidt-Krey -- In situ hybridization / Chung-Jui Tsai, Scott A. Harding -- RNA imaging : tracking in real-time RNA transport in neurons using molecular beacons and confocal microscopy / Angélica Zepeda, Clorinda Arias, Fabian Flores-Jasso, Luis Vaca.

Section I. Cell protocols : basic microbiological techniques. Pouring agar plates and streaking or spreading to isolate individual colonies / Elizabeth Eyler ; Storage of bacteria and yeast / Cheryl M. Koh -- Section II. Cell protocols : cellular fractionation. Cellular fractionation : mammalian cells / Joerg von Hagen and Uwe Michelsen ; Cellular fractionation : yeast cells / Joerg von Hagen and Uwe Michelsen -- Section III. Cell protocols : Knock-outs and gene replacements. Yeast-gene replacement using PCR products / Megan Bergkessel, Christine Guthrie, and John Abelson ; Measuring RNAi knockdown using qPCR / Stuart Milstein, Michael Nguyen, Rachel Meyers, and Antonin de Fougerolles ; Recombineering : using drug cassettes to knock out genes in vivo / James A. Sawitzke, Lynn C. Thomason, Mikhail Bubunenko, Xintian Li, Nina Costantino, and Donald L. Court ; Gene knockouts, in vivo site-directed mutagenesis and other modifications using the delitto perfetto system in Saccharomyces cerevisiae / Samantha Stuckey and Francesca Storici ; Gene targeting and site-specific recombination in mouse ES cells / Konstantinos Anastassiadis, Frank Schnütgen, Harald von Melchner, and A. Francis Stewart ; Recombineering : highly efficient in vivo genetic engineering using single-strand oligos / James A. Sawitzke, Lynn C. Thomason, Mikhail Bubunenko, Xintian Li, Nina Costantino, and Donald L. Court -- Section IV. Cell protocols : microbiological media. Growth media for E. coli / Juliane C. Lessard ; Saccharomyces cerevisiae growth media / Jessica S. Dymond --Section V. Cell protocols : preparation of slides for microscopy. Immunohistochemistry on freely floating fixed tissue sections / Julia Bachman ; Preparation of slides for microscopy from frozen tissue sections / Julia Bachman ; Preparation of formalin-fixed paraffin-embedded tissue for immunohistochemistry / Kirstie Canene-Adams ; Preparation of cells for microscopy using cytospin / Cheryl M. Koh ; Preparation of cells for microscopy using chamber slides and coverslips / Cheryl M. Koh ; Preparation of cells for microscopy using 'cell blocks' / Cheryl M. Koh -- Section VI. Lipid and carbohydrate protocols. Enzymatic deglycosylation of glycoproteins / Min-Sung Kim and Dan Leahy -- Section VII. Lipid and carbohydrate protocol : making vesicles and micelles. Preparation of fatty acid or phospholipid vesicles by thin-film rehydration / Ting F. Zhu, Itay Budin, and Jack W. Szostak ; Vesicle extrusion through polycarbonate track-etched membranes using a hand-held mini-extruder / Ting F. Zhu, Itay Budin, and Jack W. Szostak ; Preparation of fatty acid micelles / Ting F. Zhu, Itay Budin, and Jack W. Szostak -- Section VIII. Other protocols. Reverse-phase HPLC analysis and purification of small molecules / Kirstie Canene-Adams ; Thin layer chromatography / Marina Santiago and Scott Strobel ; ATP and GTP hydrolysis assays (TLC) / Vaishnavi Rajagopal and Jon R. Lorsch.

Explanatory chapter: PCR primer design / Rubén Álvarez-Fernández -- How plasmid preparation kits work / Laura Koontz -- Introducing exogenous DNA into cells / Laura Koontz -- Agarose gel electrophoresis / Laura Koontz -- Analysis of DNA by southern blotting / Gary Glenn and Lefkothea-Vasiliki Andreou -- Purification of DNA oligos by denaturing polyacrylamide gel electrophoresis (PAGE) / Sara Lopez-Gomollon and Francisco Esteban Nicolas -- Molecular cloning / Juliane C. Lessard -- Rapid creation of stable mammalian cell lines for regulated expression of proteins using the Gateway® recombination cloning technology and Flp-In T-REx® lines / Jessica Spitzer, Markus Landthaler, and Thomas Tuschl -- Restrictionless cloning / Mikkel A. Algire -- Isolation of plasmid DNA from bacteria / Lefkothea-Vasiliki Andreou -- Preparation of genomic DNA from bacteria / Lefkothea-Vasiliki Andreou -- Preparation of genomic DNA from Saccharomyces cerevisiae / Jessica S. Dymond -- Isolation of genomic DNA from mammalian cells / Cheryl M. Koh -- Sanger dideoxy sequencing of DNA / Sarah E. Walker and Jon Lorsch -- Preparation of fragment libraries for next-generation sequencing on the applied biosystems SOLiD platform / Srinivasan Yegnasubramanian -- Next generation sequencing / Srinivasan Yegnasubramanian -- Generating mammalian stable cell lines by electroporation / Patti A. Longo, Jennifer M. Kavran, Min-Sung Kim, and Daniel J. Leahy -- Transient mammalian cell transfection with polyethylenimine (PEI) / Patti A. Longo, Jennifer M. Kavran, Min-Sung Kim, and Daniel J. Leahy -- Site-directed mutagenesis / Julia Bachman -- PCR-based random mutagenesis / Jessica S. Dymond -- Megaprimer method for mutagenesis of DNA / Craig W. Vander Kooi -- Troubleshooting PCR / Kirstie Canene-Adams -- Quantitative PCR / Jessica S. Dymond -- General PCR / Kirstie Canene-Adams -- Colony PCR / Megan Bergkessel and Christine Guthrie -- Chemical transformation of yeast / Megan Bergkessel and Christine Guthrie -- Transformation of E. coli via electroporation / Juliane C. Lessard -- Transformation of chemically competent E. coli / Rachel Green and Elizabeth J. Rogers.

Computational prediction of RNA secondary structure -- Reverse-transcription PCR (RT-PCR) -- Northern blotting -- Explanatory chapter: nuclease protection assays -- In vitro transcription from plasmid or PCR-amplified DNA -- Measurement of in vivo synthesis rates -- Method for measuring mRNA decay rate in saccharomyces cerevisiae -- Analysis of polysomes from bacteria -- Polysome profile analysis - yeast -- Polysome analysis of mammalian cells -- Polysome analysis for determining mRNA and ribosome association in saccharomyces cerevisiae -- Oligo(dT)-primed RT-PCR isolation of polyadenylated RNA degradation intermediates -- Circularized RT-PCR (cRT-PCR): analysis of the 5' ends, 3' ends, and poly(A) tails of RNA -- RNA radiolabeling -- Fluorescently labeling synthetic RNAs -- Analysis of RNA by analytical polyacrylamide gel -- RNA purification by preparative polyacrylamide gel -- Explanatory chapter: nucleic acid concentration determination -- RNA purification-precipitation methods -- Reverse transcriptase dideoxy sequencing of RNA -- RNA structure experimental analysis-chemical modification -- Structural analysis of RNA backbone using in-line probing.

Laboratory Protocols in Fungal Biology presents the latest techniques in fungal biology. This book analyzes information derived through real experiments, and focuses on cutting edge techniques in the field. The book comprises 57 chapters contributed from internationally recognised scientists and researchers. Experts in the field have provided up-to-date protocols covering a range of frequently used methods in fungal biology. Almost all important methods available in the area of fungal biology viz. taxonomic keys in fungi; histopathological and microscopy techniques; proteomics methods; genomics methods; industrial applications and related techniques; and bioinformatics tools in fungi are covered and complied in one book. Chapters include introductions to their respective topics, list of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting. Each chapter is self-contained and written in a style that enables the reader to progress from elementary concepts to advanced research techniques. Laboratory Protocols in Fungal Biology is a valuable tool for both beginner research workers and experienced professionals.

Laboratory Statistics: Handbook of Formulas and Terms presents common strategies for comparing and evaluating numerical laboratory data. In particular, the text deals with the type of data and problems that laboratory scientists and students in analytical chemistry, clinical chemistry, epidemiology, and clinical research face on a daily basis. This book takes the mystery out of statistics and provides simple, hands-on instructions in the format of everyday formulas. As far as possible, spreadsheet shortcuts and functions are included, along with many simple worked examples. This book is a must-have guide to applied statistics in the lab that will result in improved experimental design and analysis. Comprehensive coverage of simple statistical concepts familiarizes the reader with formatted statistical expressionSimple, worked examples make formulas easy to use in real lifeSpreadsheet functions demonstrate how to find immediate solutions to common problemsIn-depth indexing and frequent use of synonyms facilitate the quick location of appropriate procedures.

While there are books that review lacrimal system disorders and surgery as a section of comprehensive oculoplastic textbooks, The Lacrimal System: Diagnosis, Management and Surgery solely addresses Lacrimology in one concise, practical volume. Building off of the success of the first edition, this text includes significantly updated information, new authors from around the world as well as new chapters that are complete with high quality images and illustrations. Lacrimal surgeries are commonly performed by oculoplastic surgeons and range from alleviating lacrimal system obstructions in children with congenital dysmorphology to minimally invasive lacrimal system reconstruction. The second edition of this book meets the needs of practicing physicians, fellows, and residents who are managing the tearing patient clinically and surgically.

v. 1. The mammary gland: development and maintenance -- v. 2. Biosynthesis and secretion of milk. Diseases -- v. 3. Nutrition and biochemistry of milk. Maintenance.

This book introduces readers to basic studies on and applied techniques involving lactic acid bacteria, including their bioengineering and industrial applications. It summarizes recent biotechnological advances in lactic acid bacteria for food and health, and provides detailed information on the applications of these bacteria in fermented foods. Accordingly, it offers a valuable resource for researchers and graduate students in the fields of food microbiology, bioengineering, fermentation engineering, food science, nutrition and health.

This book discusses the latest research and new techniques in the field of lactic acid bacteria, including comparative genomics, transcriptomics, proteomics and metabolomics. It also introduces the omics and functional evaluation in detail and shows the links between lactic acid bacteria and gut health and host immunity. Summarizing the biotechnological advances in lactic acid bacteria for food and health, it is a valuable resource for researchers and graduate students in the fields of food microbiology, bioengineering, food science, nutrition and health.

This book provides an overview of the physiological basis of lactic acid bacteria and their applications in minimizing foodborne risks, such as pathogens, heavy metal pollution, biotoxin contamination and food-based allergies. While highlighting the mechanisms responsible for these biological effects, it also addresses the challenges and opportunities that lactic acid bacteria represent in food safety management. It offers a valuable resource for researchers, graduate students, nutritionists and product developers in the fields of food science and microbiology.

The lake charr Salvelinus namaycush is a ubiquitous member of cold-water lake ecosystems in previously glaciated regions of northern continental U.S., Alaska, and Canada that often support important commercial, recreational, and subsistence fisheries. The lake charr differs from other charrs by its large size, longevity, iteroparity, top-predator specialization, reduced sexual dimorphism, prevalence of lacustrine spawning, and use of deepwater habitat. The species is remarkably variable in phenotype, physiology, and life history, some of which is reflected in its ecology and genetics, with as many as four morphs or ecotypes co-occurring in a single lake. The lake charr is often the top predator in these systems, but is highly adaptable trophically, and is frequently planktivorous in small lakes. The lake charr by their name highlights their common habitat, lakes both large and small, but often frequents rivers and occasionally moves into the Arctic Ocean. Movement and behaviour of lake charr are motivated by access to cool, well-oxygenated water, foraging opportunities, predator avoidance, and reproduction. Owing to their broad distribution and trophic level, the lake charr serves as a sentinel of anthropogenic change. This volume will provide an up-to-date summary of what is currently known about lake charr from distribution to genetics to physiology to ecology. The book provides a compilation and synthesis of available information on the lake charr, beginning with an updated distribution and a revised treatment of the paleoecology of the species. Understanding of ecological and genetic diversity and movement and behaviour of the species has advanced remarkably since the last major synthesis on the species over 40 years ago. Mid-sections of the book provide detailed accounts of the biology and life history of the species, and later sections are devoted to threats to conservation and fishery management practices used to ensure sustainability. A new standard lake charr-specific terminology is also presented. The book will be a valuable reference text for biologists around the world, ecologists, and fishery managers, and of interest to the angling public.

Lakes across the globe require help. The Lake Restoration Handbook: A New Zealand Perspective addresses this need through a series of chapters that draw on recent advances in modelling and monitoring tools, citizen science and First Peoples' roles, catchment and lake-focused restoration techniques, and policy implementation. New Zealand lakes, like lakes across the globe, are subject to multiple pressures that have increased in severity and scale as land use has intensified, invasive species have spread and global climate change becomes manifest. This books builds on the popular Lake Managers Handbook (1987), which provided guidance on undertaking investigations into, and understanding lake ecosystems in New Zealand. The Lake Restoration Handbook: A New Zealand Perspective synthesises contemporary issues related to lake restoration and rehabilitation, integrated with social science and cultural viewpoints, and complemented by authoritative topic-area summaries by renowned scientists and practitioners from across the globe. The book examines the progress of lake restoration and the new and emerging tools available to managers for predicting and effecting change. The book will be a valuable resource for natural and social scientists, policy writers, lake managers, and anyone interested in the health of lake ecosystems.

This book, published in two volumes, provides the most comprehensive review of lamprey biology since Hardisty and Potter's "The Biology of Lampreys" published more than 30 years ago. This second volume offers a synthesis of topics related to the lamprey gonad (e.g., lamprey sex ratios, sex determination and sex differentiation, sexual maturation, and sex steroids), the artifical propagation of lampreys, post-metamorphic feeding and the evolution of alternative feeding and migratory types, the history and status of sea lamprey control in the Laurentian Great Lakes and Lake Champlain, and an overview of contributions of lamprey developmental studies for understanding vertebrate evolution.

This book addresses current topics concerning Landau-Kleffner Syndrome (LKS) and related central auditory disorders from the perspectives of epidemiology, diagnosis, genetics and clinical treatment. LKS is a rare childhood neurological disorder and manifests auditory agnosia as the central auditory verbal dysfunction. In many cases, LKS patients also suffer from epileptic seizures. The book is divided into two parts, the first of which outlines LKS from its historical background to clinical treatment. In turn, the second part examines current topics involving related central auditory disorders, for purposes of comparing them with LKS. The book offers a valuable resource for many specialists, such as pediatric neurologists, neuropsychologists, audiologists and epileptologists, with an interest in this field.

Methodological considerations in surgical trials -- General surgery -- Emergency surgery -- Oesophagogastric surgery -- Hepatopancreaticobiliary surgery -- Colorectal surgery -- Vascular surgery -- Transplant surgery -- Breast surgery -- Endocrine surgery -- Trauma surgery.

This book describes the evolution of treatment in oncology through the lens of approximately 250 landmark clinical trials. The well-designed clinical trial is essential to the practice of medicine. There is no field that has embraced or been transformed more by the clinical trial than oncology. Each primary cancer site has a remarkable story that can be told through clinical trials. For example, patients who presented decades ago with soft tissue sarcoma of the extremities would invariably undergo limb amputation. The landmark National Cancer Institute study by Rosenberg et al. randomized patients to limb sparing surgery followed by adjuvant radiation therapy compared with limb amputation. This study helped change the standard of care by allowing most patients to retain their functioning limbs with an improvement in quality of life and no compromise in overall survival. Such major clinical trials for common malignancies including breast, prostate, lung, gastrointestinal, genitourinary, and gynecologic cancers are discussed. Because oncology is multidisciplinary, this book should be of interest for radiation oncologists, surgeons, medical oncologists, and other physicians interested in learning more about the landmark trials that have shaped oncology.

This volume is a compilation of studies on interactions of changes in land cover, land use and climate with people, societies and ecosystems in drylands of Greater Central Asia. It explores the effects of collapse of socialist governance and management systems on land use in various parts of Central Asia, including former Soviet Union republics, Mongolia and northern drylands of China. Often, regional land-atmosphere feedbacks may have large global importance. Remote sensing is a primary tool in studying vast dryland territories where in situ observations are sporadic. State-of-the-art methods of satellite remote sensing combined with GIS and models are used to tackle science questions and provide an outlook of current changes at land surface and potential scenarios for the future. In 10 chapters, contributing authors cover topics such as water resources, effects of institutional changes on urban centers and agriculture, landscape dynamics, and the primary drivers of environmental changes in dryland environment. Satellite observations that have accumulated during the last five decades provide a rich time series of the dynamic land surface, enabling systematic analysis of changes in land cover and land use from space. The book is a truly international effort by a team of scientists from the U.S., Europe and Central Asia. It is directed at the broad science community including graduate students, academics and other professionals at all levels within natural and social sciences. In particular, it will appeal to geographers, environmental and social scientists, economists, agricultural scientists, and remote sensing specialists.

This book contributes to a deeper understanding of landscape and regional modelling in general, and its broad range of facets with respect to various landscape parameters. It presents model approaches for a number of ecological and socio-economic landscape indicators, and also describes spatial decision support systems (DSS), frameworks, and model-based tools, which are prerequisites for deriving sustainable decision and solution strategies for the protection of comprehensively functioning landscapes. While it mainly focuses on the latest research findings in regional modelling and DSS in Europe, it also highlights the work of scientists from Russia. The book is intended for landscape modellers, scientists from various fields of landscape research, university teaching staff, and experts in landscape planning and management, landscape conservation and landscape policy.

This book presents the polycentric and multiscale view of landscape which has been developed in Russia within a framework of physical geography since the early twentieth century. The authors develop the ideas of hierarchical organization of a landscape and strong relationships between abiotic and biotic components with equal attention to both vertical fluxes and lateral transfer. Three-dimensional representation of landscape involves strong emphasis on abiotic drivers of pattern development including relief, geological structures and runoff. The objective of this book is to demonstrate the multiplicity of models and multiscale approach to description and explanation of landscape pattern, functioning, dynamics, and evolution. The contributions deal with various hierarchical levels ranging from within-unit interior variability to between-units interaction at landscape level, as well as regional and supra-regional zonal patterns. Divided into 8 clear parts, the 28 chapters treat spatial pattern in one of the following aspects: indicator of actual matter and energy flows control over actual processes including disturbance expansion as well as determinant of future development indicator of genesis and prerequisite for future trends driver for short-term dynamics of processes response to climatic and anthropogenic influences factor of settlement network and land use adaptation at various historical epochs framework for actual land use spatial arrangement. This contributed volume is written for researchers and students in the field of landscape ecology, physical geography, environmental impact assessment, and ecological planning.

Human well-being depends in many ways on maintaining the stock of natural resources which deliver the services from which humans benefit. However, these resources and flows of services are increasingly threatened by unsustainable and competing land uses. Particular threats exist to those public goods whose values are not well-represented in markets or whose deterioration will only affect future generations. As market forces alone are not sufficient, effective means for local and regional planning are needed in order to safeguard scarce natural resources, coordinate land uses and create sustainable landscape structures. This book argues that a solution to such challenges in Europe can be found by merging the landscape planning tradition with ecosystem services concepts. Landscape planning has strengths in recognition of public benefits and implementation mechanisms, while the ecosystem services approach makes the connection between the status of natural assets and human well-being more explicit. It can also provide an economic perspective, focused on individual preferences and benefits, which helps validate the acceptability of environmental planning goals. Thus linking landscape planning and ecosystem services provides a two-way benefit, creating a usable science to meet the needs of local and regional decision making. The book is structured around the Drivers-Pressures-State- Impact-Responses framework, providing an introduction to relevant concepts, methodologies and techniques. It presents a new, ecosystem services-informed, approach to landscape planning that constitutes both a framework and toolbox for students and practitioners to address the environmental and landscape challenges of 21st century Europe.

Medical terminology -- Microbiology -- Pharmacology and anesthesia -- Blood values -- Aseptic technique -- Sterilization and disinfection -- Operating room environment -- Transportation and positioning -- Counts -- Specimens -- Medical, ethical, and legal responsibilities -- Diagnostic procedures -- Consents -- Skin preparation and draping -- Instruments -- Sutures, stapling devices, and drains -- Wound healing and dressings -- General surgery -- Obstetrics and gynecology -- Ophthalmology -- Otorhinolaryngology -- Plastic and reconstructive surgery -- Genitourinary -- Thoracic -- Cardiac -- Vascular -- Neurosurgery -- Orthopedics -- Pediatrics -- Biomedical science (Electricity, hemostasis, lasers, and computers) -- Occupational hazards/fire safety -- Endoscopy, minimally invasive surgery, and robotics.

Offering exceptional full color diagrams and clinical images, Langman's Medical Embryology, 13e helps medical, nursing, and health professions students develop a basic understanding of embryology and its clinical relevance. Concise chapter summaries, captivating clinical correlates boxes, clinical problems, and a clear, concise writing style make the subject matter accessible to students and relevant to instructors. The new edition is enhanced by over 100 new and updated illustrations, additional clinical images and photos of early embryologic development, and an expanded chapter on the cardiovascular system. Clinical Correlates boxes illustrated by cases and images cover birth defects, developmental abnormalities, and other clinical phenomena. More than 400 illustrations?including full-color line drawings, scanning electron micrographs, and clinical images?clarify key aspects of embryonic development. Basic genetic molecular biology principles are highlighted throughout the text to link embryology to other critical specialties. Chapter Overview figures provide a visually compelling introduction to each chapter. Problems to Solve (with detailed answers at the back of the book) help you assess your understanding. An expanded glossary defines key terms and concepts. Online learning resources for students include an interactive question bank and animations.

"Every student will be affected by pregnancy, either their mother's, because what happens in the womb does not necessarily stay in the womb, or by someone else's. As health care professionals, you will often encounter women of childbearing age who may be pregnant, or you may have children of your own, or maybe it is a friend who is pregnant. In any case, pregnancy and childbirth are relevant to all of us, and unfortunately, these processes often culminate in negative outcomes. For example, 50% of all embryos are spontaneously aborted. Furthermore, prematurity and birth defects are the leading causes of infant mortality and major contributors to disabilities. Fortunately, new strategies can improve pregnancy outcomes, and health care professionals have a major role to play in implementing these initiatives. However, a basic knowledge of embryology is essential to the success of these strategies, and with this knowledge, every health care professional can play a role in providing healthier babies. To accomplish its goal of providing a basic understanding of embryology and its clinical relevance, Langman's Medical Embryology retains its unique approach of combining an economy of text with excellent diagrams and clinical images. It stresses the clinical importance of the subject by providing numerous clinical examples that result from abnormal embryological events. The following pedagogic features and updates in the 14th edition help facilitate student learning"--Provided by publisher.

"Every student will be affected by pregnancy, either: 1. Directly from their own gestation, since adverse exposures during their mother's pregnancy can have lasting healthcare effects postnatally; 2. having their own child; 3. having a patient who is pregnant"-- Provided by publisher.

The enigma of schizophrenia -- Language in schizophrenia -- Schizophrenic language : the cognitive perspective -- Schizophrenic language : the philosophical perspective -- An alternative view : schizophrenia as a disease of language.

Gynaecological surgery has made tremendous strides in the last 30 years, due to advances in medical imaging, operative laparoscopy, and new types of prosthesis. Reconstructive plastic surgery of pelvic organ prolapse and of urinary incontinence have benefited from these developments. The laparoscopic sacropopexy and laparoscopic lateral suspension with meshes are two excellent examples. In order to successfully perform these operations, detailed knowledge of the anatomy of the pelvic floor as "seen from above", i.e., from the abdominal view, is an invaluable asset. Achieving perfect knowledge of the anatomical details is now possible, thanks to laparoscopy. With the aid of laparoscopy, following subperitoneal dissections, reconstructive surgery of the pelvic floor can be made substantially more precise, more exact, and also more anatomical. This atlas will allow gynaecologic surgeons to deepen and improve their anatomical expertise, with the aid of laparoscopy. It also describes in detail the most common laparoscopic operative techniques. The book represents a new and unique approach to anatomy studied in the living, and supplements the main content with a wealth of straightforward and clearly explained photographs.

This book provides comprehensive advice and recommendations to surgeons practicing the laparoscopic repair of incisional hernias. It opens with a brief history and evolution of the technology surrounding the repair of incisional and ventral hernias laparoscopically and includes the introduction of robotic technology, which is constantly undergoing further refinement as new devices are introduced. The text discusses areas of controversy, as well as the limits and benefits of using this technology in the laparoscopic approach. Written by the current thought leaders of minimally invasive techniques, this helpful resource provides current opinions and methods in incisional and ventral hernia repair. Laparoscopic And Robotic Incisional Hernia Repair: Current Considerations provides a valuable resource for both seasoned laparoscopic surgeons interested in the technical aspects of incisional and ventral hernia repair.

This book is a practical guide to the laparoscopic and robotic surgery technique in urology. It includes 34 chapters in three sections, which are adrenal gland, kidney and ureter surgery, bladder and prostate surgery and lympadenectomy. This book covers all parts of laparoscopic and robotic urological surgery, including methods in patient selection, peri-operative management, step-by-step descriptions of specific techniques and complication avoidance. It is accompanied with over 800 illustrations and real-time capture figures. It also includes over 40 surgery videos with online access. Through the combination of texts, pictures and videos, it presents the surgical designing, surgical procedures and surgical techniques in panorama. This book is a good reference book for urologists who interested in these techniques.

"his book, written by expert surgeons, offers a comprehensive and up-to-date overview of all aspects of laparoscopic cholecystectomy. Coverage includes the indications for surgery, anesthesia, establishment of pneumoperitoneum, surgical technique, and the prevention and management of complications. Performance of laparoscopic cholecystectomy in the specific contexts of biliary tree stones and acute cholecystitis is described. Extensive reference is made to the latest clinical evidence, and the real benefits of the laparoscopic approach, for example in terms of outcomes and day surgery, are carefully assessed. New technologies, including SILS, NOTES, robotic surgery, and miniaturized instruments, are reviewed. The learning curve and training are also extensively discussed, and an individual chapter is devoted to the views of international experts in the field. Some 20 years after the National Institutes of Health Consensus Conference first published recommendations regarding indications for laparoscopic cholecystectomy, it remains the gold standard approach and continues to evolve."--Publisher's website.

This book is designed specifically to help equip new surgeons with the anatomical and technical knowledge to supplement hands on experience in minimally invasive colon and rectal surgery. There are multiple colorectal surgeries which distinctly lend themselves to the use of the laparoscopic approach. To assist the junior surgeon who is embarking on a career in surgery, expert surgeons and educators in the field of colon and rectal surgery from around the country authored the chapters included in this book. Chapters describe key elements of each surgery, including the order of surgery, when and how the surgeon created tension, rotated the patient, and optimized flow of the surgery. Chapters also contain tips and pitfalls that are not always explicitly presented when describing a surgical approach in order to provide readers with a diverse toolkit. Each chapter is also full of new illustrations that show the direction of traction, the line of dissection, and the anatomy of the colon. The illustrations also present tools in a color-coded format to clearly distinguish between the surgeons and the assistants tools. Laparoscopic Colectomy: A Step by Step Guide is a valuable resource to residents and junior attendings who wish to master laparoscopic colon and rectal surgery.

1 Milestones in Laparoscopic Colon Surgery -- 2 Types of Colon Surgery and Anatomy -- 3 Pre-operative Evaluation and Selection of Patients -- 4 Instruments -- 5 Surgical Techniques -- 6 Complications in Laparoscopic Colorectal Surgery -- 7 Robotic Colon Surgery and Quality of Life. -- 8 Laparoscopic Colon Surgery: Education and Best Practices -- 9 Anaesthesia in Laparoscopic Colorectal Surgery.

This unique guide describes colorectal surgery procedures using medical terminology and anatomical terms originating from embryology. In the last decade, laparoscopic procedures in gastrointestinal surgery have been enhanced and their safety has significantly improved. With the number of cases of colorectal cancer surgery increasing and laparoscopic surgery no longer considered a specialized surgery, the recognition of the correct anatomy is vital in these procedures. Unfortunately, however, the understanding of clinical anatomy is frequently separate from that of basic surgical concepts. Initially, the dissecting layer should be presumed to derive from the fascial anatomy based on embryological recognition. Furthermore, the techniques currently being used by surgeons should be described in sufficient detail and the appropriate anatomical terms should always be used. In view of this, this valuable monograph benefits gastrointestinal surgeons and general surgeons who are involved in the treatment of colorectal cancer.

This book provides a concise overview of several critically important techniques and their applications within Laparoscopic Common Bile Duct Exploration (LCBDE). LCBDE is rapidly emerging as the preferential management option for treating patients with common bile duct (CBD) stones. Chapters within this book describe how this technique can be applied to manage patients with concomitant gallstones, which aims to increase the exploration of the CBD via the transcystic route. Particular mention is made for the use of energy devices to enable stone fragmentation within the bile duct also known as Lithotripsy-Assisted Bile duct Exploration by Laparoendoscopy (LABEL). Guidance is also provided on how to set-up an acute biliary service which can offer the single-stage management of concomitant gallstones and choledocholithiasis. The concepts of Leveraging Access to Technology and Enhanced Surgical Techniques (LATEST)--in LCBDE and Biliary Surgery 2.0--as the framework through which these techniques can be further enhanced are analysed. Laparoscopic Common Bile Duct Exploration features insight into how to perform these increasingly important procedures successfully and set-up a service within institutions that are yet to provide it. Therefore, it is a valuable resource for all medical professionals involved in the care of these patients.

Anatomy of the Liver in the Laparoscopic Situation -- Instruments for Laparoscopic Hepatectomy by Curettage and Aspiration -- Laparoscopic Left Lateral Segmentectomy -- Laparoscopic Left Hemihepatectomy -- Laparoscopic Right Hemihepatectomy -- Laparoscopic Resection of Caudate Lobe -- Laparoscopic Non-Anatomical Liver Resection -- Two-Stage Completely Laparoscopic Hemihepatectomy -- Laparoscopic Radical Resection of Gallbladder Cancer -- Other Techniques for Laparoscopic Hepatectomy.

Laparoscopic Anatomical Hepatectomy -- Positioning and Accesses -- Preoperative Preparation and Anesthesia -- Laparoscopic Fenestration of Liver Cyst -- Laparoscopic Partial Hepatectomy -- Laparoscopic Single-site Hepatectomy -- Laparoscopic Left Lateral Sectionectomy -- Laparoscopic Left Hepatectomy -- Laparoscopic Right Posterior Sectoretomy -- Retroperitoneal Laparoscopic Hepatectomy -- Laparoscopic Right Hepatectomy -- Laparoscopic Caudate Lobectomy -- Radiofrequency Ablation Assisted Laparoscopic Hepatectomy -- Robotic Assisted Laparoscopic Hepatectomy.

This book offers a concise and easy-to-understand overview of facts and concepts in pelvic anatomy. Laparoscopy provides good vision in a limited field, which means that surgeons have to rely on their anatomical knowledge of what structures lie in the vicinity and which structures need to be preserved. Focusing on surgical anatomy, the book helps laparoscopic surgeons better understand the female pelvic structures so improve their surgical skills. -- Provided by publisher.

This book offers a practical surgical guide, helping surgeons learn the technique needed to perform Laparoscopic SacroColpoPexy (LSCP). To do so, it explains the surgical process in straightforward language, supplemented by images and diagrams, while also discussing why this procedure is so effective. The book has two primary goals: to provide those surgeons who have never performed LSCP before with essential insights and technical expertise, based on the author's 20 years of practical surgical experience; and to allay the common fear of possible complications. Following a 2012 FDA warning, surgeons whose work involved vaginal prolapse repair have been looking for an alternative technique. Though LSCP offers a safe alternative to current methods, the available literature on it is sparse. This book provides a comprehensive guide to the techniques and methods needed by surgeons operating on pelvic organ prolapse in a range of different specialties, including urogynecology, urology, and gynecology.

This book provides a complete guide to laparoscopic sleeve gastrectomy and the management of obesity. The chapters discuss guidelines for healthcare providers for the management of patients with obesity, the rationale behind choosing patients, performing the procedure in line with the patient's condition, the perioperative period, postoperative requirements, and postoperative complications. This book aims to give readers an understanding of the surgical techniques involved in laparoscopic sleeve gastrectomy and the wider treatment options available. It is relevant to bariatric, metabolic, and general surgeons, physicians, clinical nutritionists as well as students.

Esophagus and Stomach -- Liver, Gallbladder, and Biliary Tree -- Abdominal Wall -- Colon, Rectum, and Appendix -- Kidney, Adrenal Gland, Ureter, and Varicocele -- Spleen and Pancreas -- Bariatic Surgery -- Gynecology.

Chapter 1 Principles of Anatomy -- Chapter 2 Evidence of Laparoscopic Surgery for Colorectal Cancer -- Chapter 3 Right-sided Colectomy (ileo-cecal resection, right-hemicolectomy, extended right-hemicolectomy) -- Chapter 4 Transverse Colectomy -- Chapter 5 Left Sided Colectomy (mobilization of splenic, sigmoidectomy) -- Chapter 6 Laparoscopic Total Mesorectal Excision (TME) for Rectal Cancer -- Chapter 7 Procedures of Right Lateral Pelvic Lymph Node Dissection (LPLND) with Pelvic Autonomic Nerve Preservation -- Chapter 8 Restorative Proctocolectomy -- Chapter 9 Transanal Minimally Invasive Surgery for Rectal Cancer -- Chapter 10 Robotic Total Mesorectal Excision.

This book presents the latest advances in laparoscopic spleen surgery. The first chapter reviews current status of laparoscopic spleen surgery, including indications, contraindications, and various types of surgical techniques. In the following three chapters, anatomy of spleen, pathology of spleen diseases, and perioperative management are described. After that, surgical techniques of laparoscopic splenectomy, single-incision laparoscopic splenectomy, hand-assisted laparoscopic splenectomy, and laparoscopic partial splenectomy are introduced with high-resolution illustrations combined with typical clinical cases. Focusing on minimally invasive surgery in spleen, this book will be a valuable reference for general surgeons, as well as practitioners in related disciplines.

When Laparoscopy in Children was first published in 2003, it quickly became popular with pediatric surgeons worldwide owing to its clear schematic drawings and concise text. This new edition has been revised and enlarged to cover the new procedures and other advances that have emerged in the intervening period, during which the number of operations has almost doubled. Now, the vast majority of indications for laparoscopy in children are presented and discussed. Each operation is systematically described and illustrated step by step, providing the reader with the technical guidelines required to perform laparoscopy safely even in small children. Laparoscopy in Children will be an invaluable guide for all surgeons who perform, or plan to perform, such operations.

"The acclaimed full-color guide to selecting the correct laboratory test and interpreting the results covering ALL of clinical pathology Laboratory Medicine is the most comprehensive, user-friendly, and well-illustrated guide available for learning how to order the correct laboratory test and understand the clinical significance of the results. The book features an easy-to-follow, consistent presentation for each disease discussed. Chapters begin with a brief description of the disorder followed by a discussion that includes tables detailing the laboratory evaluation of specific disorders, diagnosis, baseline tests to exclude diagnostic possibilities, and clinical indications that warrant further screening and special testing. With new, increasingly expensive and complicated tests appearing almost daily, Laboratory Medicine, Third Edition is required reading for medical students, clinical laboratory scientists, and healthcare professionals who want to keep abreast of the latest testing procedures and maximize accuracy and patient safety. Features: 48 clinical laboratory methods presented in easy-to-understand illustrations that include information on the expense and complexity of the assays More than 200 tables and full-color algorithms that encapsulate important information and facilitate understanding Full-color blood-smear micrographs that demonstrate common abnormal morphologies of red blood cells Valuable learning aids in each chapter, including learning objectives, chapter outlines, and a general introduction -- and new to this edition: chapter-ending self-assessment Q&A. Logical systems-based organization that complements most textbooks Extensive table of Clinical Laboratory Reference Values that show the conversions between U.S. and SI units for -- Provided by publisher.

In this book, detailed information on the nosology, pathology, pathogenesis, clinical presentation, diagnosis and treatment of large- and medium-sized vessel and single-organ vasculitis is provided and critically discussed by the most expert physicians and researchers in the field. Among the conditions considered are giant cell arteritis, Takayasu arteritis, polyarteritis nodosa, primary central nervous system vasculitis, isolated aortitis, isolated gastrointestinal vasculitis, cutaneous vasculitis and isolated genitourinary vasculitis. The role of histopathology in the diagnosis and prognosis of these vasculitis is evaluated, along with the part played by imaging studies in diagnosing and monitoring these diseases, while indications and limitations of the available imaging modalities are discussed as well. The expanding role of biological agents for the treatment of the large vessel vasculitis is addressed, as well as the current approaches to these diseases. This book will be a valuable companion in decision-making for medical practitioners, internists, specialists, researchers and postgraduate students interested in the intriguing fields of vasculitis and rare diseases.

"Ongoing advances in innovative technologies have improved the diagnosis and treatment of laryngeal cancer, resulting in more optimal oncologic and functional patient outcomes. Laryngeal Cancer: Clinical Case-Based Approaches, by distinguished head and neck surgeon Rogério A. Dedivitis and internationally recognized coeditors, is a comprehensive reference that presents multiple options for similar lesions. Contributions from a diverse group of globally renowned subspecialists reflect the multidisciplinary treatment of laryngeal cancer. The book focuses on diverse primary subsites of laryngeal cancer; local, early-stage, and advanced disease stages; and current available treatment modalities for each type. Case study chapters include insightful discussion of several potential approaches, rationale for surgical decision making, radiographic findings, pearls, and pitfalls"--Provided by publisher.

Introduction to laryngeal dissection and surgery -- Dissection -- Endoscopic laryngeal surgery -- Office-based laryngeal surgery -- Open laryngeal phonosurgery -- Cancer surgies -- Open laryngotracheal surgery.

'Laryngology' is a compact yet comprehensive resource on the management of disorders of voice, airway and swallowing. It discusses the latest techniques in laryngeal documentation, key principles in management of laryngeal disorders, outcome measures and quality-of-life assessment, and evolving technologies in laryngology.

This text comprehensively reviews the current state of the art in Laryngopharyngeal Reflux (LPR) together with a comprehensive explanation and description of the known gastroesophageal reflux (GERD) literature. With chapters written by experts from around the world, this text aims to deliver what is current in reflux recognition, diagnosis, reflux related complications, and the various treatment modalities. This is the first textbook to combine the most up to date knowledge of both LPR and GERD meant for both specialties and the general medicine population. Completely unique to the reflux literature is a section detailing the substantial benefits of a mostly plant based, Mediterranean style diet in the treatment of reflux disease. Encouraging patients to read and learn about diet and health is likely the most important step in improving their disease. The text provides direction to the caregiver on how to transition to a mostly plant-based diet. Review of myths, effects of diet in the setting of other disease states, and dietary consequences are explained. Guidelines on how to transition diet, dining out while maintaining a plant-based diet, and how to wean off medication, such as PPI, are also provided. Laryngopharyngeal and Gastroesophageal Reflux: A Comprehensive Guide to Diagnosis Treatment, and Diet-Based Approaches will provide the medical community with a resource to understand, teach, and provide the latest in LPR and GERD information to the caregiver and subsequently the patient. .

This comprehensive text provides the reader with an in-depth understanding of laryngopharyngeal reflux (LPR), and presents a practical and readable evidence-based approach to the diagnosis and management of patients with this condition. It highlights options for management of those patients who fail to improve with traditional reflux treatment and assists in determining the next steps in the management of this population. Information is presented from an inter-disciplinary perspective, including input by otolaryngology, gastroenterology, speech pathology, and complementary/integrative medicine. The first section of the book is dedicated to understanding the fundamentals of laryngopharyngeal reflux as a condition. It begins with a review of the fundamental anatomy and pathophysiology of LPR and summarizes the landmark and most recent advances in the scientific understanding of this condition. Subsequent chapters delve into the typical symptoms and clinical presentations of patients, with information provided on cost-effective work-up strategies to confirm the diagnosis. The second section focuses on management of this condition. It begins with a thorough review of traditional medical management, including use of proton pump inhibitors, histamine receptor antagonists, neutralizing agents, low acid diet, alkalinizing agents, and alginates. Surgical management is reviewed as well, including partial and full fundoplication operations. It concludes with "non-traditional" treatment options for LPR, with chapters dedicated to voice therapy, probiotics, herbal therapies, and integrative East-West medicine approaches. Laryngopharyngeal Reflux Disease will be a definitive guide for otolaryngologists, gastroenterologists, speech pathologists, and general physicians with an interest in traditional and complementary/integrative treatments for patients with laryngopharyngeal reflux.

This is the second edition of a well-received book that has been revised and updated to reflect the state of the art in laser and light source technology. After an initial chapter describing the latest understanding of laser physics and safety, subsequent chapters consider laser treatment of vascular lesions, laser treatment of pigmented lesions and tattoos, laser removal of unwanted hair, ablative and non-ablative fractional resurfacing, and use of laser treatment for medical purposes. The book is extremely practical and reader friendly. All chapters are very well illustrated, include quick and clear bullet points, and feature a homogeneous structure covering core concepts, currently available technologies, indications and contraindications, an example of a consent form, and the author's personal treatment approaches. The authors are without exception world experts in the field from North America or Europe.

This book addresses the management of scars using lasers and light. The authors provide a comprehensive overview of the current laser modalities and the science and evidence behind them. They also present various treatments, including those using carbon dioxide lasers, Erbium:YAG lasers, pulsed dye lasers and Q-switched lasers. The book includes detailed information on the treatment of burn, acne, keloid and hypertrophic scars, as well as discussions of the complications of laser treatments and ethical and medico-legal issues. Scars have many causes, including trauma and burns, but also medical treatments themselves - scars are an inevitable consequence of most surgery. There have been significant advances in laser and light technology over the last decade, and the management of scars with a variety of lasers has been adopted both in traditional healthcare settings and in the cosmetic sector. Edited by a respected burns and plastic surgeon, this book is a valuable resource for a variety of clinicians including dermatologists, laser practitioners, physiotherapists and occupational therapists, burn care professionals, as well as multidisciplinary teams working with patients with scars of all aetiologies.

1. Introduction to laser-induced transfer and other associated processes -- 2. Origins of laser-induced transfer processes -- 3. LIFT using a dynamic release layer -- 4. Laser-induced forward transfer of fluids -- 5. Advances in blister-actuated laser-induced forward transfer (BA-LIFT) -- 6. Film-free LIFT (FF-LIFT) -- 7. Laser-induced forward transfer of metals -- 8. LIFT of solid films (ceramics and polymers) -- 9. Laser-induced transfer of soft materials -- 10. Congruent LIFT with high-viscosity nanopastes -- 11. Laser printing of nanoparticles -- 12. Laser printing of electronic materials -- 13. Laser printing of chemical and biological sensors -- 14. Laser printing of proteins and biomaterials -- 15. Laser-assisted bioprinting of cells for tissue engineering -- 16. Industrial, large-area, and high-throughput LIFT/LIBT digital printing -- 17. LIFT of 3D metal structures -- 18. Laser transfer of entire structures and functional devices.

This book describes and illustrates state-of-the-art techniques in laser spine surgery. Laser technology has revolutionized surgeries in many specialties to perform minimally invasive and cutting-edge procedures. Recent advances in spinal surgery have led to the increasingly widespread use of minimally invasive techniques based on endoscopy and microscopy. Nevertheless, the application of laser in the context of spinal surgery remains less well known, and the aim of this book is to present practical usage of laser in spine surgery to our readers. A wide variety of minimally invasive approaches to spine surgery using CO2, Ho: YAG, and Nd: YAG lasers are presented in detail, with a discussion of equipment and specific recommendations on laser settings. Care has been taken to ensure that the content is faithful to the fundamental principles of spine surgery and evidence-based medicine. The book will be an essential resource for all who use or are intending to use lasers in spine surgery.

Part I: The History of Laser Therapy -- Part II: The Theory and Science of Laser Therapy -- Part III: Practical Applications of Laser Therapy -- Part IV: Clinical Applications of Laser Therapy in Companion Animals -- Part V: Clinical Applications of Laser Therapy in Canine Sports Medicine -- Part VI: Clinical Applications of Laser Therapy in Companion Animal Rehabilitation -- Part VII: Clinical Applications of Laser Therapy in Exotic Animals -- Part VIII: Clinical Applications of Laser Therapy in Equine Practice -- Part IX: Clinical Applications of Laser Therapy in Food Animal Practice -- Part X: Laser Therapy and Alternative and Regenerative Therapies -- Part XI: Integrating Laser Therapy into Veterinary Medicine.

Today, nearly 60 years after the invention of the first medical laser, multiple laser and light systems exist and are applied in various medical specialties such as dermatology, ophthalmology, and urology. This volume - the first in the series Aesthetic Dermatology - focuses on the laser treatment of cutaneous lesions with a vascular target. Each chapter describes a particular laser or light modality and its specific application to a variety of both vascular and nonvascular lesions. Renowned specialists in laser medicine have contributed their expertise, incorporating current evidence-based literature and their own personal treatment recommendations, as well as pearls and perils. The purpose of this book is to explore the options and parameters available to treat cutaneous lesions traditionally responsive to vascular laser therapy and to expand the application to further lesion treatments. Readers who wish to broaden their knowledge and further hone their skills in treating cutaneous vascular lesions with lasers will find this publication a valuable and comprehensive review.

The series “Clinical Approach and Procedures in Cosmetic Dermatology” intends to be a practical guide in Cosmetic Dermatology. Procedures in cosmetic dermatology are very popular and useful in medicine, indicated to complement topical and oral treatments not only for photodamaged skin but also for other dermatosis such as acne, rosacea, scars, etc. Also, full-face treatments using peelings, lasers, fillers and toxins are increasingly being used, successfully substituting or postponing the need for plastic surgeries. Altogether, these techniques not only provide immediate results but also help patients to sustain long-term benefits, both preventing/treating dermatological diseases and maintaining a healthy and youthful skin. Throughout this series, different treatments in Cosmetic Dermatology will be discussed in detail covering the use of many pharmacological groups of cosmeceuticals, the new advances in nutraceuticals and emerging technologies and procedures. This volume addresses the most important physical approaches in cosmetic dermatology, disclosing their uses and advantages. Here are discussed in detail the applicability of lasers and other lights, photodynamic therapy, radiofrequency, ultrasound and transepidermal drug delivery.

Comprehensive coverage of the use of lasers and related technologies for skin rejuvenation, This text offers a practical, step-by-step coverage on the use of lasers, ultrasound, radiofrequency, and other technologies for skin improvement. Helps dermatologists maximize the usefulness of this technology in their daily practice.

Preface -- Laser physics and laser sources for cardiovascular applications -- Optic fibers and mechanical properties of laser catheters -- Landmarks along the introduction of laser to cardiovascular therapy -- Laser-thrombus interaction: from basic research to clinical utilization in the management of cardiovascular diseases -- Laser for treatment of acute coronary syndromes -- Laser for management of ST-elevation acute myocardial infarction -- Laser for revascularization of complex targets: old SVGs, CTO, left main disease, stent restenosis -- Laser utilization for synergistic technology strategy for coronary revascularization: laser and directional rotablation; laser combined with drug eluting balloon -- Laser for revascularization of peripheral arterial disease- SFA, renal, subclavian, carotid arteries -- Laser for infra-popliteal revasculariztion -- TMR- physiology, pathology and basic research concepts -- TMR-endovascular and surgical techniques and clinical outcomes -- Laser application for venous thrombosis -- Laser for IVC filter removal -- Laser for interventional electrophysiology ? extraction and removal of pacemaker and AICD leads -- Laser for treatment of cardiac arrhythmias -- Laser application for treatment of congenital heart disease -- Nursing perspectives of cardiovascular laser procedures -- Laser safety in the cardiovascular suite and the operation room -- Laser induced cardiovascular complications : mechanisms, recognition and management -- Laser in cardiovascular veterinary medicine.

In the book of 'Lasers in Dermatology: Parameters and Choice,' specific laser parameters are described around each laser instrument for these novices. However, since it is impossible to treat effective and safe laser simply by memorizing parameters, it is described based on the important principles that is essential for parameter control. This book describes a total of 13 lasers and energy-based devices : Q-switched ruby laser, Q-switched Nd:YAG laser, picosecond alexandrite laser, long-pulsed Nd:YAG laser, pulsed-dye laser, intense pulsed light (IPL), long-pulsed alexandrite laser, Er:YAG laser, CO2 fractional laser, fractional microneedle radiofrequency (RF), light-emitting diode (LED), skin equipment, and 1,450nm diode laser. And for novices, it explains the simple principles of lasers and the concepts you need to know when you start skin care and laser. It also explains the treatment of scars and melasma, which are the diseases that novices are most interested in. Finally, it describes post-inflammatory (PIH) and side effects and complications that novices are embarrassed about in diagnosis and treatment.

Along with its sister dermatologic volume, this comprehensive textbook of laser technology covers the use of lasers to treat vascular anomalies and lesions, control of pigmented lesions and tattoos, hair removal, acne, facial rejuvenation, Psoriasis, hypopigmented lesions and Vitiligo. Chapters are formatted in an easy to follow format with clear concise sections with bulleted summaries to highlight key points. Lasers in Dermatology and Medicine: Dermatologic Applications provides detailed explanations of when lasers can be of use how to use them across a range of medical disciplines. Clinically relevant examples are provided along with relevant images and summary boxes to highlight key points. It therefore provides a critical resource on the applications and use of lasers across medicine for both the trainee and trained clinician.

This book provides surgeons with important insights into laser technologies as well as a sound understanding of their current and potential applications within oral and maxillofacial surgery and related disciplines. The opening chapters focus on the relevant physical background, the technology of the typically used lasers, laser-tissue interactions, and the treatment systems. Detailed information is then provided on the various established applications of laser treatments, including in relation to skin and mucosa and the dental hard tissues and bone. Special applications are also described, for example with respect to periodontal surgery, peri-implantitis therapy, photodynamic treatment, holography and additive manufacturing. The book closes by examining technologies that will soon be available for application in hospitals, topics which are currently the subject of research, and laser safety. Beyond surgeons, the book will be of value for engineers and scientists working in the field of medical engineering using lasers.

This multidisciplinary book introduces all the known and unknown facts, tips, and tricks of laser procedures in various anorectal disorders including haemorrhoids, fistula in ano, anal fissure, pilonidal sinus, etc. It describes minimally invasive procedures, provides authoritative, in-depth presentations of all perspectives of this latest technique. Each chapter includes surgical anatomy, clinical evaluation, and the principle behind hybrid procedures, complications, and solutions that may arise while using Lasers. The book also discusses case presentations in various scenarios and a brief comparison of laser techniques with conventional procedures. It includes an up-to-date scientific and clinical data for quick reference. It emphasizes on "What to do, How to do and What not to do." This is a must-read book for all trainees and surgeons practicing anorectal disorders, providing an overview of the latest treatment options. This book empowers surgeons with in-depth knowledge and enhance their skills to manage common anorectal diseases. It will serve as a valuable guide for residents, clinicians, surgeons, researchers, and proctologists keen to use lasers as a futuristic approach to deal with anorectal disorders.

Section I. LASIK fundamentals -- section II. Diagnostic equipment -- section III. Flap-making equipment -- section IV. Excimer lasers -- section V. Management of postsurgical problems -- section VI. Other surgical considerations -- section VII. Study section -- section VIII. International perspectives in refractive surgery.

This book describes a paradigm shift for all of humanity -- We are at a point where we may be the last generation that is still partially or fully natural. We are often balancing on the precipice between science and science fiction, now ready to tip the scales and slide comfortably into the future of great discoveries and wonderful changes. Many crucial and important questions are addressed in the pages of this book, including: what are the true medical and social problems facing us? Which are the highest value targets we need to focus on to ensure our best route of success? How can we protect our futures and enhance our lives by understanding what it means to be the "last natural humans" to roam this planet? The Last Natural Man combines a fascination with the history of medicine, evolutionary biology, and medical anthropology and mix it with modern medicine and science to investigate how we evolved and where we are headed. The overall result is a clear and engaging guidebook for navigating the often confusing and cloudy waters of the future of medicine and our life on Earth.‍?‍? Cultural evolution has been the major driving force over the last several thousand years and enormous in its influence compared to almost invisible changes in our physical adaptations. If cultural and religious evolution was the driver for human history, are we now entering the phase of physical transformation ? where humanity refuses to accept mortality and seeks to make changes to defeat nature. ‍In this book the authors are describing a paradigm shift of all of humanity?just as hunter-gatherers had their stellar features, the future man will have many attractive qualities, even if many artificial. We are often balancing on the precipice between science and science fiction, now ready to tip the scales and slide comfortably into the future of great discoveries and wonderful changes. But are these changes all for the good? What will being human mean.

"Whether we like it or not, we all die. People avoid talking about death because it is too mysterious, too dark, and occasionally, as in the case of an accidental or other sudden death, too unpredictable. Because we do not discuss death and dying in our current culture, people are left to wrestle with large questions about death. This book is a place to start thinking about, and preparing for, this inevitable event. The primary goal of The Last Things We Talk About is to help readers affirm, celebrate, and remember the people and experiences they cherish in this life. It encourages them to seriously consider their death and take planning one step at a time, according to their schedule, and as energy permits. Elizabeth Boatwright, DMin, BCC-PCHAC, CFP is a Relief Chaplain in Oncology Outpatient Palliative Care Medicine at Stanford Health Care. She has over 25 years in ministry experience serving diverse cultures along with extensive work in the arts and financial planning"-- Provided by publisher.

"Late-Life Depression and Anxiety empowers health care professionals to identify and diagnose anxiety and depression in older adult patients and help them find relief, stay independent, and lower their risk of suicide. Readers will gain up-to-date knowledge of the scope and seriousness of depression, anxiety, and suicide in older adults, alongside a system of proven assessment and treatment techniques for turning evidence-based theory into practice"-- Provided by publisher.

This volume analyses the distinct care needs of late preterm infants and their parents by reflecting on the best available evidence to inform on practice and latest innovations in care. It addresses the spectrum of issues experienced by late preterm infants and their parents to ensure their health life trajectories. We define late preterm infants as those born between 34 to 36 weeks' gestational age. The book uses creative writing prompts and a narrative style to gain insight and self-reflection in and on practice to move the reader to embracing best practices. Issues such as mother's physical and emotional health, father's burden in postpartum period and neurodevelopmental outcomes of late preterm infants are specifically addressed. Areas of innovation are shared for consideration to prompt readers thinking about continuous improvement in quality of care. The book shares local and global perspectives to address the common concerns related to care of late preterm infants and their families, and to foster a partnership in promoting their health all across the globe. It is intended to any health care providers such as nurses, midwives, physicians and other allied care professionals like health visitors, community health workers.

This comprehensive guide describes the aftercare that is appropriate in young cancer patients and discusses in detail the risk and detection of treatment sequelae. It explains the impacts on body and mind of both the disease itself and the different risk-adapted cancer treatments currently in use. Clear guidance is provided on diagnosis and management of the principal treatment-related toxicities in different organs and organ systems and for a wide variety of tumor types. In addition, the role of genetic polymorphisms in the development of adverse therapy-related outcomes is explored, and advice offered on genetic counselling. As the number of long-term survivors of childhood cancer and of cancer in young adults continues to grow, so issues surrounding potential sequelae, second malignancies, and quality of life are becoming ever more important. All practitioners involved in the care of young cancer patients will find this book to be a helpful source of up-to-date information and assistance.

This well-illustrated textbook is the first comprehensive and authoritative source of information on minimally invasive lateral access spine surgery. It covers all aspects of the subject, including patient selection, approach and monitoring techniques, soft tissue management, application in a variety of pathologies, technical nuances, and the prevention and management of complications. In addition, current controversies in the field are discussed and the biomechanics of lateral spinal reconstruction, the physiologic benefits, and cost implications are explained. Over the past decade, the emergence of minimally invasive lateral access spine surgery has created a revolution in spine treatment. This trend began with the introduction of extreme lateral interbody fusion, a totally new spinal procedure. In recent years, the conversion of more than 15% of lumbar spinal fusion procedures to a lateral approach has been due to the unique advantages of this approach over conventional anterior or posterior surgery. All major purveyors of spinal products and implants have entered this market enthusiastically, and all major spinal societies now conduct annual cadaveric and didactic courses to teach the technique. As use of the lateral approach in spinal surgery has become more popular, so its diversity and complexity have increased. Nevertheless, coverage in the literature is typically limited to single chapters, and the spinal surgeon seeking to achieve optimal results must rely on chance discussions with colleagues at meetings to learn the latest information. Lateral Access Minimally Invasive Spine Surgery is designed to fill this vacuum. Written by world experts on the topic, it will be an excellent resource for both beginning and experienced surgeons.

This superbly illustrated, up-to-date reference textbook covers all aspects of ankle instability and its management. Readers will find extensive information on biomechanics, injury prevention, current strategies for conservative treatment, and established and emerging surgical techniques. The most recent procedures, particularly those which are minimally invasive and arthroscopically assisted, are described and discussed in depth. Detailed attention is also devoted to controversies such as the indications and timing for conservative or surgical treatment, the current and future roles of arthroscopy, the definition of "anatomic" repair, and the upcoming concept of "anatomic reconstruction" (replication of anatomy by using a graft). The book is published in cooperation with ESSKA, and the chapter authors include clinicians and scientists working in the field of foot and ankle orthopaedics and sports medicine from across the world. All who are involved in the care of patients suffering from ankle instability, including amateur and high-level athletes, will find Lateral Ankle Instabilityto be an excellent source of knowledge and a valuable aid to clinical practice. .

"Although the phenomenon of lateral gene transfer has been known since the 1940s, it was the genomics era that has really revealed the extent and many facets of this evolutionary/genetic phenomenon. Even in the early 2000s with but a handful of genomes available, it became clear that the nature of microorganisms is full of genetic exchange between lineages that are sometimes far apart. The years following this saw an explosion of genomic data, which shook the "tree of life" and also raised doubts about the most appropriate species concepts for prokaryotes. This book represents the manyfold contributions of LGT to the evolution of micro and, to an extent, macroorganisms by focusing on the areas where it has the largest impact: metabolic innovations and adaptations and speciation." Back cover.

The Lateral Line System provides an overview of the key concepts and issues surrounding the development, evolution, neurobiology, and function of the lateral line, a fascinating yet somewhat enigmatic flow-sensing system. The book examines the historical precedence for linking the auditory and lateral line systems, its structure and development, use of the lateral line system of zebrafish as a model system, physical principles governing the response properties of the lateral line, the behavioral relevance of this sensory system to the lives of fish, and an examination of how this information

The Lateralized Brain: The Neuroscience and Evolution of Hemispheric Asymmetries is an up-to-date teaching resource for neuroscience faculty members that teach courses concerning hemispheric asymmetries. The book provides students with all relevant information on the subject, while also giving aspiring researchers in the field an up-to-date overview of relevant, previous work. It is ideal for courses on hemispheric asymmetries, that is, the functional or structural differences between the left and the right hemispheres of the brain, and also highlights how the widespread use of modern neuroimaging techniques, such as fMRI and DTI has completely changed the way hemispheric asymmetries are currently investigated.

Latin America is a megadiverse territory hosting several hotspots of plant diversity and many types of forest biomes, ecosystems and climate types, from tropical rainforest to semi-arid woodlands. This combination of diverse forests and climates generates multiple responses to ecological changes affecting the structure and functioning of forest ecosystems. Recently, there have been major efforts to improve our understanding of such impacts on ecosystems processes. However, there is a dearth of studies focused on Latin-American forest ecosystems that could provide novel insights into the patterns and mechanisms of ecological processes in response to environmental stress. The abundance of "New World" tree species with dendrochronological potential constitutes an ideal opportunity to improve the ecological state of knowledge regarding these diverse forest types, which are often threatened by several impacts such as logging or conversion to agricultural lands. Thus, detailed information on the dendroecology of these species will improve our understanding of forests in the face of global change. Accordingly, this book identifies numerous relevant ecological processes and scales, ranging from tree species to populations and communities, and from both dendrochronological and dendroecological perspectives. It offers a valuable reference guide for the exploration of long-term ecological interactions between trees and their environmental conditions, and will foster further research and international projects on the continent and elsewhere.

Taking a social justice stance, this book highlights the unique characteristics of the farmworker population in the eastern United States. It examines the health and living conditions of this underserved population, while advocating for equality.

"The Latinx Guide to Grad School offers readers advice on the graduate school process-from the application stage to the cultivating of effective networks in academia-in an accessible guidebook. It provides a broader institutional analysis as well as grounded advice for prospective and current graduate students navigating doctoral and Master's programs, with a specific focus on the humanities and social sciences, areas of study with significant Latinx representation. Genevieve Negrón-Gonzales and Magdalena L. Barrera have worked for many years as professors, thesis advisors, dissertation chairs, instructors, and mentors within institutions with a large percentage of Latinx undergraduate and graduate students. They identify common challenges, key questions, and helpful techniques for supporting Latinx students that will be helpful for both students and faculty mentors. This book offers their refined approaches to working with Latinx students in a way that both pushes them forward in their work and academic goals in an ethical, socially-engaged manner that still offers a critical assessment of institutions of higher education."-- Provided by publisher.