Books

Macrophages are core components of the innate immune system. Once activated, they may have either pro- or anti-inflammatory effects that include pathogen killing, safe disposal of apoptotic cells or tissue renewal. The activation state of macrophages is conceptualized by the so-called M1/M2 model of polarization. M2 macrophages are not simply antagonists of M1 macrophages; rather, they represent a network of tissue resident macrophages with roles in tissue development and organ homeostasis. M2 macrophages govern functions at the interfaces of immunity, tissue development and turnover, metabolism, and endocrine signaling. Dysfunction in M2 macrophages can ruin the healthy interplay between the immune system and metabolic processes, and lead to diseases such as insulin resistance, metabolic syndrome, and type 1 and 2 diabetes mellitus. Furthermore, M2 macrophages are essential for healthy tissue development and immunological self-tolerance. Worryingly, these functions of M2 macrophages can also be disrupted, resulting in tumor growth and autoimmunity. This book comprehensively discusses the biology of M2 macrophages, summarizes the current state of knowledge, and highlights key questions that remain unanswered.

Training and program development / Timothy Jang, Michael J. Lambert -- Equipment / William Scruggs, J. Christian Fox -- Physics and image artifacts / Corky Hecht, William Manson -- Ultrasound in prehospital and austere environments / William Heegaard -- Trauma / O. John Ma, James R. Mateer, Andrew W. Kirkpatrick -- Cardiac / Robert F. Reardon, Scott A. Joing -- Pulmonary / Lisa Mills, Fernando Silva -- Critical care / Robert Reardon, Gavin Budhram, and David Plummer -- Abdominal aortic aneurysm / Robert F. Reardon, Dave Plummer, Thomas Cook -- Hepatobiliary / Daniel Theodoro, Resa Lewiss -- General surgery / Masaaki Ogata -- Renal / Stuart Swadron, Dina Seif -- Testicular / Srikar Adhikari -- First trimester pregnancy / Robert F. Reardon, Scott A. Joing -- Second and third trimester pregnancy / Barry Knapp, Don Byars -- Gynecologic concepts / Michael J. Lambert, J. Christian Fox -- Deep venous thrombosis / Tom Constantino, Harry Goett, Michael Peterson -- Soft tissue / Andreas Dewitz -- Ocular / Matt Lyon, Dietrich Jehle -- Pediatric applications / Jason Fischer, Adam Sivitz, and Alyssa Abo -- Vascular access / John S. Rose, Aaron E. Bair, Aman K. Parikh -- Additional ultrasound-guided procedures / Andreas Dewitz ... [et al.].

1. Brief history of the stone of madness -- 2. The prescientific stage of the pineal gland -- 3. The beginnings of the pineal scientific era: from the late nineteenth century of melatonin's discovery -- 4. Sleep/wake cycle: history and facts -- 5. When this chronicler enters the story: the 1960s -- 6. The stone of madness as a neuroendocrine organ and model: the 1970s -- 7. Peripheral innervation of neuroendocrine-immune system: the challenges to change of physiological paradigm -- 8. Melatonin as a potential therapeutic agent: the 1980s -- 9. Melatonin as a chronobiotic that opens the "gates of sleep": the 1990s -- 10. Melatonin and the "diseases of the soul": the stone of madness returns -- 11. Twenty-first century: the 24/7 society as an environmental mutation -- 12. Melatonin as a medicament for the 24/7 society: metabolic syndrome -- 13. Melatonin as a medicament for the 24/7 society: normal and pathological aging -- 14. Melatonin as a medicament for the 24/7 society: cancer -- 15. Melatonin as a nutraceutical -- Epilogue -- Index.

Sect. II: Preparation and suport -- Sect. II: Physiologic monitoring -- Sect. III: Blood sampling -- Sect. IV: Miscellaneous sampling -- Sect. V: Vascular access -- Sect. VI: Respiratory care -- Sect. VII: Tube placement and care -- Sect. VIII: Transfusions -- Sect. IX: Miscellaneous procedures

This book, now in an extensively revised and updated second edition, provides a comprehensive overview of both machine learning and deep learning and their role in oncology, medical physics, and radiology. Readers will find thorough coverage of basic theory, methods, and demonstrative applications in these fields. An introductory section explains machine and deep learning, reviews learning methods, discusses performance evaluation, and examines software tools and data protection. Detailed individual sections are then devoted to the use of machine and deep learning for medical image analysis, treatment planning and delivery, and outcomes modeling and decision support. Resources for varying applications are provided in each chapter, and software code is embedded as appropriate for illustrative purposes. The book will be invaluable for students and residents in medical physics, radiology, and oncology and will also appeal to more experienced practitioners and researchers and members of applied machine learning communities. .

Ecologists and natural resource managers are charged with making complex management decisions in the face of a rapidly changing environment resulting from climate change, energy development, urban sprawl, invasive species and globalization. Advances in Geographic Information System (GIS) technology, digitization, online data availability, historic legacy datasets, remote sensors and the ability to collect data on animal movements via satellite and GPS have given rise to large, highly complex datasets. These datasets could be utilized for making critical management decisions, but are often "messy" and difficult to interpret. Basic artificial intelligence algorithms (i.e., machine learning) are powerful tools that are shaping the world and must be taken advantage of in the life sciences. In ecology, machine learning algorithms are critical to helping resource managers synthesize information to better understand complex ecological systems. Machine Learning has a wide variety of powerful applications, with three general uses that are of particular interest to ecologists: (1) data exploration to gain system knowledge and generate new hypotheses, (2) predicting ecological patterns in space and time, and (3) pattern recognition for ecological sampling. Machine learning can be used to make predictive assessments even when relationships between variables are poorly understood. When traditional techniques fail to capture the relationship between variables, effective use of machine learning can unearth and capture previously unattainable insights into an ecosystem's complexity. Currently, many ecologists do not utilize machine learning as a part of the scientific process. This volume highlights how machine learning techniques can complement the traditional methodologies currently applied in this field.

This book highlights the fundamental association between aquaculture and engineering in classifying fish hunger behaviour by means of machine learning techniques. Understanding the underlying factors that affect fish growth is essential, since they have implications for higher productivity in fish farms. Computer vision and machine learning techniques make it possible to quantify the subjective perception of hunger behaviour and so allow food to be provided as necessary. The book analyses the conceptual framework of motion tracking, feeding schedule and prediction classifiers in order to classify the hunger state, and proposes a system comprising an automated feeder system, image-processing module, as well as machine learning classifiers. Furthermore, the system substitutes conventional, complex modelling techniques with a robust, artificial intelligence approach. The findings presented are of interest to researchers, fish farmers, and aquaculture technologist wanting to gain insights into the productivity of fish and fish behaviour.

This book bridges the gap between data scientists and clinicians by introducing all relevant aspects of machine learning in an accessible way, and will certainly foster new and serendipitous applications of machine learning in the clinical neurosciences. Building from the ground up by communicating the foundational knowledge and intuitions first before progressing to more advanced and specific topics, the book is well-suited even for clinicians without prior machine learning experience. Authored by a wide array of experienced global machine learning groups, the book is aimed at clinicians who are interested in mastering the basics of machine learning and who wish to get started with their own machine learning research. The volume is structured in two major parts: The first uniquely introduces all major concepts in clinical machine learning from the ground up, and includes step-by-step instructions on how to correctly develop and validate clinical prediction models. It also includes methodological and conceptual foundations of other applications of machine learning in clinical neuroscience, such as applications of machine learning to neuroimaging, natural language processing, and time series analysis. The second part provides an overview of some state-of-the-art applications of these methodologies. The Machine Intelligence in Clinical Neuroscience (MICN) Laboratory at the Department of Neurosurgery of the University Hospital Zurich studies clinical applications of machine intelligence to improve patient care in clinical neuroscience. The group focuses on diagnostic, prognostic and predictive analytics that aid in decision-making by increasing objectivity and transparency to patients. Other major interests of our group members are in medical imaging, and intraoperative applications of machine vision.

This book reviews all aspects of the use of machine learning in contemporary dentistry, clearly explaining its significance for dental imaging, oral diagnosis and treatment, dental designs, and dental research. Machine learning is an emerging field of artificial intelligence research and practice in which computer agents are employed to improve perception, cognition, and action based on their ability to learn for example through use of big data techniques. Its application within dentistry is designed to promote personalized and precision patient care, with enhancement of diagnosis and treatment planning. In this book, readers will find up-to-date information on different machine learning tools and their applicability in various dental specialties. The selected examples amply illustrate the opportunities to employ a machine learning approach within dentistry while also serving to highlight the associated challenges. Machine Learning in Dentistry will be of value for all dental practitioners and researchers who wish to learn more about the potential benefits of using machine learning techniques in their work.

Adequate health and health care is no longer possible without proper data supervision from modern machine learning methodologies like cluster models, neural networks, and other data mining methodologies. The current book is the first publication of a complete overview of machine learning methodologies for the medical and health sector, and it was written as a training companion, and as a must-read, not only for physicians and students, but also for any one involved in the process and progress of health and health care. In this second edition the authors have removed the textual errors from the first edition. Also, the improved tables from the first edition, have been replaced with the original tables from the software programs as applied. This is, because, unlike the former, the latter were without error, and readers were better familiar with them. The main purpose of the first edition was, to provide stepwise analyses of the novel methods from data examples, but background information and clinical relevance information may have been somewhat lacking. Therefore, each chapter now contains a section entitled "Background Information". Machine learning may be more informative, and may provide better sensitivity of testing than traditional analytic methods may do. In the second edition a place has been given for the use of machine learning not only to the analysis of observational clinical data, but also to that of controlled clinical trials. Unlike the first edition, the second edition has drawings in full color providing a helpful extra dimension to the data analysis. Several machine learning methodologies not yet covered in the first edition, but increasingly important today, have been included in this updated edition, for example, negative binomial and Poisson regressions, sparse canonical analysis, Firth's bias adjusted logistic analysis, omics research, eigenvalues and eigenvectors. -- Provided by publisher.

This book provides a complete overview of the role of machine learning in radiation oncology and medical physics, covering basic theory, methods, and a variety of applications in medical physics and radiotherapy. An introductory section explains machine learning, reviews supervised and unsupervised learning methods, discusses performance evaluation, and summarizes potential applications in radiation oncology. Detailed individual sections are then devoted to the use of machine learning in quality assurance; computer-aided detection, including treatment planning and contouring; image-guided radiotherapy; respiratory motion management; and treatment response modeling and outcome prediction. The book will be invaluable for students and residents in medical physics and radiation oncology and will also appeal to more experienced practitioners and researchers and members of applied machine learning communities.

This book offers a diagnostic tool for physicians and psychologists who want to systematically document pain within a multimodal structure. MACPainP (multiaxial classification of pain-psychosocial dimension) is a systematic, comprehensive and clinically oriented diagnostic instrument for evaluating pain-related disorders, and includes differentiated descriptions to enable syndromes to be systematized and diagnoses compared. MACPainP can be used as a professional add-on for the International Classification of Diseases ICD-10 as well as the upcoming pain classification ICD-11, released by WHO. This clearly structured book provides an easy introduction to the biopsychological aspects of pain disorders, to allow a nuanced approach to the psychological diagnosis of pain patients. It discusses possible comorbidities (e.g. depressive disorders, anxiety disorders) as well as concrete behavior-related steps for pain-related psychological and medical treatments. An essential reference for physicians and psychologists in the field of pain therapy, it is part of the learning European Pain Federation Curriculum (EFIC) of pain therapists.

Introduction: brief historical overview -- Distribution of MACPF/CDC proteins -- Evolution of the complement system -- Structural features of cholesterol dependent cytolysins and comparison to other MACPF-domain containing proteins -- Perfringolysin O structure and mechanism of pore formation as a paradigm for cholesterol-dependent cytolysins -- Structural biology of the membrane attack complex -- Membrane interactions and cellular effects of MACPF/CDC proteins -- The biology of pneumolysin -- Multifaceted activity of listeriolysin O, the cholesterol -dependent cytolysin of Listeria monocytogenes -- Perforin: a key pore-forming protein for immune control of viruses and cancer -- Perforin and human diseases -- The role of MACPF proteins in the biology of malaria and other apicomplexan parasites -- Chlamydial MACPF protien CT153 -- Fungal MACPF-like proteins and aegerolysins: bi-component pore-forming proteins? -- Fluorescence imaging of MACPF/CDC proteins: new techniques and their application.

This book includes an international group of researchers who present the latest achievements in the field of enzyme, immune system, and microbial and nano-biosensors. It highlights the experimental evidence for formation of biological fuel cells (BFCs)-which has a dual purpose - as a device that produces electricity and the systems which produce it simultaneously cleaning up the environment from polluting organic compounds. Considering the work in the field of macro, micro and nano-biosensors, considerable attention is paid to the use of nanomaterials for the modification of working electrodes. Nanomaterials in some cases can significantly improve the parameters of analytical systems. Readers will be interested in the projection of the presented theoretical and experimental materials in the field of practical application of modern analytical developments. The presented results in many cases imply the possibility of using the created models of macro, micro and nano-biosensors, and biofuel elements in the field of health, and protection/restoration of the environment. It includes information about all existing types of transducers of signals in biosensors - electrochemical, optical and quantum-optics, thermoelectric, data of atomic force microscopy, piezoelectric, and more. On the basis of these principles, descriptions are given about the functioning of macro, micro and nano- biosensors for the detection of compounds used in medicine, detection of compounds that clog the environment, and thus affect human health, for compounds that are potentially the basis for the production of drugs, for the selection of compounds that have medicinal activity, for immunodetection, and to assess the quality of food. These questions form the basis of research carried out in the field of biosensors in the world. Since the described models of biosensors have high sensitivity, high measurement speed and selectivity, the described results attract the attention of both the ordinary reader and business class specialists who create and implement analytical technologies. This book is very useful for researchers in life sciences, chemical sciences, physics, and engineering. In addition, it will be useful for the persons working in industry. Advanced technologies specialists will be attracted by the novelty of the proposed solutions and their relevance and ease of implementation. Since the studies contain sections describing the parameters of different biosensors, BFCs, they are easily navigated into assessing the effectiveness of the practical use of the proposed device. The relevant sections indicate such characteristics as detection ranges, life span, type of biological material used, the method of formation of the bio-receptor part. These parameters are of interest to both developers of new models of biosensors and BFC, and their manufacturers.

Synthesis of chain-end functionalized glycopolymers via cyanoxyl-mediated free radical polymerization (CMFRP) / Valentinas Gruzdys ... [et al.] -- Protecting-group-free synthesis of well-defined glycopolymers featuring negatively charged oligosaccharides / Luca Albertin -- Glycopolymers prepared by ring-opening metathesis polymerization followed by glycoconjugation using a triazole-forming "click" reaction / Ronald Okoth and Amit Basu -- Protecting-group-free synthesis of glycopolymers and their binding assay with lectin and influenza virus / Tomonari Tanaka, Tadanobu Takahashi, and Takashi Suzuki -- Carbohydrate-based initiators for the cationic ring-opening polymerization of 2-Ethyl-2-Oxazoline / Christine Weber ... [et al.] -- Heterofunctional glycopolypeptides by combination of Thiol-Ene chemistry and NCA polymerization / Kai-Steffen Krannig and Helmut Schlaad -- Preparation of proteoglycan mimetic graft copolymers / Matt J. Kipper and Laura W. Place -- Galactosylated polymer nano-objects by polymerization-induced self-assembly, potential drug nanocarriers / Mona Semsarilar, Irene Canton, and Vincent Ladmiral -- Synthetic approach to biotinylated glyco-functionalized quantum dots : a new fluorescent probes for biomedical applications / Christian K. Adokoh, James Darkwa, and Ravin Narain -- Surface modification of polydivinylbenzene microspheres with a fluorinated glycopolymer using Thiol-Halogen click chemistry / Wentao Song and Anthony M. Granville -- Glycopolymer-grafted polymer particles for lectin recognition / Michinari Kohri, Tatsuo Taniguchi, and Keiki Kishikawa -- Synthesis of non-spherical glycopolymer-decorated nanoparticles : combing Thiol-ene with catecholic chemistry / Xiao Li, Weidong Zhang, and Gaojian Chen -- Synthetic approach to glycopolymer base nanoparticle gold(I) conjugate : a new generation of therapeutic agents / Christian K. Adokoh, James Darkwa, and Ravin Narain -- Multivalent glycopolymer-coated gold nanoparticles / Sarah-Jane Richards ... [et al.] -- Modulation of multivalent protein binding on surfaces by glycopolymer brush chemistry / Kai Yu ... [et al.] -- Oriented immobilized sialyloligo-macroligand microarray / Satya Nandana Narla and Xue-Long Sun -- Glycocalyx remodeling with glycopolymer-based proteoglycan mimetics / Mia L. Huang ... [et al.].

Structure and function of the stressosome signalling hub / Jan Pané-Farré, Maureen B. Quin, Richard J. Lewis, Jon Marles-Wright -- The canonical inflammasome: a macromolecular complex driving inflammation / Tom P. Monie -- The Ferritin Superfamily / Alejandro Yévenes -- Antibody recognition of immunodominant vaccinia virus envelope proteins / Dirk M. Zajonc -- The peroxiredoxin family: an unfolding story / Zhenbo Cao, John Gordon Lindsay -- [alpha]2-Macroglobulins: structure and function / Irene Garcia-Ferrer, Aniebrys Marrero, F. Xavier Gomis-Rüth, Theodoros Goulas -- The Structure and Function of the PRMT5:MEP50 complex / Stephen Antonysamy -- Symmetry-directed design of protein cages and protein lattices and their applications / Aaron Sciore, E. Neil G. Marsh -- Structure and function of RNA polymerases and the transcription machineries / Joachim Griesenbeck, Herbert Tschochner, Dina Grohmann -- Dihydrodipicolinate synthase: structure, dynamics, function, and evolution / F. Grant Pearce, André O. Hudson, Kerry Loomes, Renwick C. J. Dobson -- Pyruvate carboxylase, structure and function / Mikel Valle -- Cullin-RING E3 ubiquitin ligases: bridges to destruction / Henry C. Nguyen, Wei Wang, Yong Xiong -- The Ccr4-Not complex: architecture and structural insights / Martine A. Collart, Olesya O. Panasenko -- Higher-order structure in bacterial VapBC toxin-antitoxin complexes / Kirstine L. Bendtsen, Ditlev E. Brodersen -- D-glyceraldehyde-3-phosphate dehydrogenase structure and function / Michael R. White, Elsa D. Garcin -- Protein complexes in the nucleus: the control of chromosome segregation / Victor M. Bolanos-Garcia -- GroEL and the GroEL-GroES complex / Noriyuki Ishii -- The aminoacyl-tRNA synthetase complex / Marc Mirande -- The pyruvate dehydrogenase complex and related assemblies in health and disease / Olwyn Byron, John Gordon Lindsay -- Structure and assembly of clathrin cages / Mary Halebian, Kyle Morris, Corinne Smith.

This book follows on from Volume 83 in the SCBI series ("Macromolecular Protein Complexes"), and addresses several important topics (such as the Proteasome, Anaphase Promoting Complex, Ribosome and Apoptosome) that were not previously included, together with a number of additional exciting topics in this rapidly expanding field of study. Although the first SCBI Protein Complex book focused on soluble protein complexes, the second (Vol. 87)addressed Membrane Complexes, and the third (Vol. 88) put the spotlight on Viral Protein and Nucleoprotein Complexes, a number of membrane, virus and even fibrillar protein complexes have been be considered for inclusion in the present book. A further book is also under preparation that follows the same pattern, in an attempt to provide a thorough coverage of the subject. Chapter "Structure and Function of Roundabout Receptors" is available open access under a CC BY 4.0 license via link.springer.com.

This book covers important topics such as the dynamic structure and function of the 26S proteasome, the DNA replication machine: structure and dynamic function and the structural organization and protein-protein interactions in the human adenovirus capsid, to mention but a few. The 18 chapters included here, written by experts in their specific field, are at the forefront of scientific knowledge. The impressive integration of structural data from X-ray crystallography with that from cryo-electron microscopy is apparent throughout the book. In addition, functional aspects are also given a high priority. Chapter 1 is available open access under a Creative Commons Attribution 4.0 International License vialink.springer.com.

Evolutionary Aspects of Macrophages Polarization / Eva-Stina Edholm, Kun Hyoe Rhoo, and Jacques Robert -- Development and Functional Differentiation of Tissue-Resident Versus Monocyte-Derived Macrophages in Inflammatory Reactions Paola Italiani and Diana Boraschi -- Hofbauer Cells: Placental Macrophages of Fetal Origin / Leticia Reyes, Bryce Wolfe, and Thaddeus Golos -- Mesenchymal Stem Cells Direct the Immunological Fate of Macrophages / Patricia Luz-Crawford, Christian Jorgensen, and Farida Djouad -- Monocyte/Macrophage: NK Cell Cooperation--Old Tools for New Functions / Elżbieta Wałajtys-Rode and Jolanta M. Dzik -- Macrophages in Invertebrates: From Insects and Crustaceans to Marine Bivalves / Prasad Abnave, Xavier Muracciole, and Eric Ghigo -- F4/80 as a Major Macrophage Marker: The Case of the Peritoneum and Spleen / Alexandra dos Anjos Cassado -- Immunobiology of Nitric Oxide and Regulation of Inducible Nitric Oxide Synthase / Martin Lee [and others] -- Role for Mechanotransduction in Macrophage and Dendritic Cell Immunobiology / Svenja F. B. Mennens, Koen van den Dries, and Alessandra Cambi -- Macrophages' Role in Tissue Disease and Regeneration / Lewis Gaffney [and others] -- Macrophages and Their Contribution to the Development of Atherosclerosis / Yuri V. Bobryshev [and others] -- Macrophage Dysfunction in Respiratory Disease / Kylie B. R. Belchamber and Louise E. Donnelly -- Activation of Macrophages in Response to Biomaterials / Jamie E. Rayahin and Richard A. Gemeinhart -- Macrophage Differentiation in Normal and Accelerated Wound Healing / Girish J. Kotwal and Sufan Chien -- Macrophages and RhoA Pathway in Transplanted Organs / Yianzhu Liu [and others].

Structure, function, and responses to injury / James Crawford, Prodromos Hytiroglou, and Paulette Bioulac-Sage -- Cellular and molecular techniques / Pierre Bedossa, Valerie Paradis, and Jessica Zucman Rossi -- Developmental and inherited liver disease / Alberto Quaglia, Eve A. Roberts, and Michael Torbenson -- Disorders of iron overload / Antonello Pietrangelo and Michael Torbenson -- Fatty liver disease / Dina G. Tiniakos, Alastair Burt, and Quentin M. Anstee -- Viral hepatitis / Henry Charles Bodenheimer Jr., Maria Guido, and Neil D. Theise -- Other viral and infectious diseases / Sherif Zaki, Venancio Alves, and Gillian Leigh Hale -- Autoimmune hepatitis / Kay Washington and Michael P. Manns -- Bile duct diseases / Yoh Zen, Stefan Hubscher, and Yasuni Nakanuma -- Diseases of the gallbladder / Brian C. Quigley and N. Volkan Adsay -- Vascular disorders / Pierre Bedossa, Prodromos Hytiroglou, and Matthew M. Yeh -- Drugs and toxins / David Kleiner -- Tumours and tumourlike lesions / Linda D. Ferrell, Sanjay Kakar, Aileen Wee, and Luigi M. Terracciano -- Transplantation pathology / Stefan Hübscher, Andrew Clouston, and Anthony J. Demetris -- Liver in systemic disease / Alastair Burt and Chris Bellamy.

Written and edited by an international team of renowned authorities, MacSween's Pathology of the Liver, 8th Edition, remains the field's definitive reference on liver pathology. This must-have text is ideal for surgical pathologists in practice and in training who examine liver specimens on a day-to-day basis. It provides invaluable assistance in recognizing the huge variety of appearances of the liver that result from infections, tumors, and tumor-like lesions, as well as organ damage caused by drugs and toxins. With expert, comprehensive coverage of all malignant and benign hepatobiliary disorders, MacSween's is a convenient, one-stop resource for use in the reporting room as well as in personal study. Shares the knowledge and experience of a "who's who" list of experts in the field of hepatobiliary pathology, led by editors Alastair D. Burt, Linda D. Ferrell, and Stefan G. Hübscher. Features more than 1,000 high-quality, full color illustrations, providing a complete visual guide to each tumor or tumor-like lesion. Discusses advances in molecular diagnostic testing, its capabilities, and its limitations, including targeted/personalized medicine. Incorporates the latest TNM staging and WHO classification systems, as well as new diagnostic biomarkers and their utility in differential diagnosis, newly described variants, and new histologic entities. Includes relevant data from ancillary techniques (immunohistochemistry, cytogenetics, and molecular genetics), giving you the necessary tools required to master the latest breakthroughs in diagnostic technology. Provides you with all of the necessary diagnostic tools to make a complete and accurate pathologic report, including clinicopathologic background throughout. Directs you to the most recent and authoritative sources for further reading with a comprehensive reference list that highlights key articles and up-to-date citations. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

This atlas presents chapters on common and rare macular diseases including variants of age-related macular degeneration (dry, neovascular, polypoidal choroidal vasculopathy), cystoid macular edema, macular telangiectasia, central serous retinopathy and pachychoroid disease, photic retinopathy, presumed ocular histoplasmosis syndrome, myopic degeneration, angioid streaks, and a recently described entity: perifoveal exudative vascular anomalous complex. It provides a wealth of representative images, using various modalities to help the reader recognize the respective conditions. Importantly, it also includes images acquired using techniques more recently adopted in clinical practice such as autofluoresence, optical coherence tomography (OCT), and OCT angiography. The concise text reviews the basic concepts of etiology, diagnosis, and management in a highly accessible format. In contributions prepared by internationally respected experts, the atlas provides a cutting-edge analysis of each condition, as well as excellent summaries of recent work in the field. Macular Disorders is one of nine volumes in the series Retina Atlas. The series offers a global perspective on vitreoretinal diseases, covering imaging basics, retinal vascular disease, ocular inflammatory disease, retinal degeneration, surgical retina, macular disorders, ocular oncology, pediatric retina and trauma. In nine volumes and over 100 chapters, Retina Atlas offers comprehensive and validated information on retinal disorders.

Stargardt's disease (STGD) -- Macular Abnormalities in Panretinal Dystrophies -- Best Disease -- Pattern Dystrophy.- Autosomal Dominant Drusen -- North Carolina Makular Dystrophy (NCMD, MCDR1) and NCMD-like Disorders -- Sorsby Fundus Dystrophy -- Central Areolar Choroidal Dystrophy -- Maternally Inherited Diabetes and Deafness (MIDD) -- X-linked Retinoschisis (XLRS) -- Miscellaneous Very Rare Macular Dystrophies -- Management and Interventions.

Macular edema : definition and basic concepts / Coscas, Gabriel; Cunha-Vaz, José; Soubrane, Gisèle -- Mechanisms of retinal fluid accumulation and blood-retinal barrier breakdown / Cunha-Vaz, José -- Intracellular edema / Narayanan, Raja; Kuppermann, Baruch D -- Central serous chorioretinopathy / Daruich, Alejandra; Matet, Alexandre; Behar-Cohen, Francine -- Diagnosis and detection / Staurenghi, Giovanni; Pellegrini, Marco; Invernizzi, Alessandro; Preziosa, Chiara -- Optical coherence tomography angiography in macular edema / Lupidi, Marco; Coscas, Florence; Cagini, Carlo; Coscas, Gabriel -- Macular edema : rationale for therapy / Wolfensberger, Thomas J -- Drug delivery to the posterior segment of the eye / Moisseiev, Elad; Loewenstein, Anat -- Diabetic macular edema / Bandello, Francesco; Battaglia Parodi, Maurizio; Lanzetta, Paolo; Loewenstein, Anat; Massin, Pascale; Menchini, Francesca; Veritti, Daniele Retinal Vein Occlusions / Jonas, Jost; Monés, Jordi; Glacet-Bernard, Agnès; Coscas, Gabriel -- Insights into the physiopathology of inflammatory macular edema / de Smet, Marc D. -- Postsurgical cystoid macular edema / Zur, Dinah; Loewenstein, Anat -- Retinitis pigmentosa and other dystrophies / Mrejen, Sarah; Audo, Isabelle; Bonnel, Sébastien; Sahel, José-Alain -- Macular edema of choroidal origin / Soubrane, Gisèle -- Miscellaneous / Creuzot-Garcher, Catherine.

Recent technological advances in the diagnosis of macular disorders have enhanced our understanding of these diseases. At the same time, advances in small-gauge vitrectomy instrumentation and techniques have improved the safety and efficiency of surgery, allowing macular conditions that would have otherwise resulted in blindness to be treated effectively, preserving patients' sight. Macular surgery continues to evolve rapidly, thanks to exciting future technology trends. This book provides a detailed and up-to-date overview of the field. It begins with essential information on macular anatomy and pathophysiology, examination techniques, and surgical instrumentation. In turn, it discusses a broad range of disease processes, including macular holes, epiretinal membrane, vitreomacular traction and myopic maculopathy. The role and benefits of advanced vitrectomy techniques including submacular surgery, prosthetic vision, robotic surgery, and stem cell and gene therapy are addressed in detail. A review of perioperative care and potential complications rounds out the coverage.

Section 1: Practice Management & Development. 1. Reptile Practice Management 2. Reference Resources for the Reptile Clinician 3. Understanding the Human-Reptile Relationship 4. Veterinary Specialization 5. The Importance of Herpetological Publication by Clinicians and Academics 6. Statistics for the Clinician -- Section 2: Biology (Taxonomy, Anatomy, Physiology and Behavior). 7. Taxonomy, Anatomy and Physiology of Tortoises, Turtles and Terrapins 8. Taxonomy, Anatomy and Physiology of Snakes 9. Taxonomy, Anatomy and Physiology of Lizards 10. Taxonomy, Anatomy and Physiology or Crocodilians 11. Taxonomy, Anatomy and Physiology of Tuataras 12. Taxonomy, Anatomy and Physiology of Amphibians 13. Natural Behaviors 14. Conditioning and Behavioral Training 15. Stress and Welfare of Reptiles and Amphibians -- Section 3: Husbandry and Management. 16. General Husbandry and Management of Reptiles 17. Environmental Lighting 18. Disinfection 19. Quarantine 20. Snakes 21. Lizards 22. Management of Venomous Species 23. Tortoises, Freshwater Aquatic Turtles and Terrapins 24. Sea Turtles 25. Crocodilians 26. Tuatara 27. Nutrition 28. General Husbandry and Management of Amphibians -- Section 4: Infectious Diseases and Laboratory Sciences. 29. Bacteriology 30. Virology 31. Mycology 32. Parasitology Including Hemoparasites 33. Hematology 34. Clinical Chemistry 35. Hematology and Biochemistry Tables 36. Molecular Diagnostics 37. Immunopathology 38. Cytology 39. Biopsy 40. Necropsy 41. Commercial and Analytical Labs -- Section 5: Techniques and Procedures. 42. Handling and Physical Examination 43. Diagnostic Techniques and Sample Collection 44. Catheter Placement 45. Esophogastric Feeding Tube Placement 46. Hospitilization 47. Euthanasia -- Section 6: Anesthesia. 48. Sedation 49. General Anestheisa 50. Analgesia 51. Regional Anesthesia and Analgesia 52. Amphibian Anesthesia -- Section 7: Diagnostic Imaging. 53. Radiography -- General Principles 54. Radiography -- Lizards 55. Radiography -- Snakes 56. Radiography -- Chelonians 57. Radiography -- Crocodilians 58. Ultrasonography 59. Computed Tomography 60. Magnetic Resonance Imaging 61. Scintigraphy -- Section 8: Endoscopy. 62. Diagnostic and Surgical Endoscopy Equipment 63. Endoscopy practice management and marketing 64. Diagnostic Endoscopy 65. Endoscope-Assisted and Endoscopic Surgery -- Section 9: Medicine. 66. Urology 67. Hepatology 68. Cardiology 69. Dermatology I (Skin) 70. Dermatology II (Shell) 71. Ophthalmology 72. Otorhinolaryngology 73. Gastroenterology I (Oral cavity, esophagus, stomach) 74. Gastroenterology II (Small and large intestines) 75. Gastroenterology III (Cloaca) 76. Pulmonology 77. Neurology 78. Oncology 79. Endocrinology 80. Theriogenology 81. Musculoskeletal 82. Vascular, Hematopoietic Immunology 83. Clinical Behavioral Medicine 84. Nutritional Diseases 85. Perinatology 86. Geriatrics 87. Emergency and Critical Care 88. Toxicology 89. Amphibian Medicine Overview -- Section 10: Surgery. 90. Surgical Equipment, Instrumentation and General Principles 91. Eye 92. Ear 93. Rhinarium 94. Oral Cavity 95. Venemoid surgery 96. Integument -- Skin 97. Coeliotomy -- Snake 98. Coeliotomy -- Lizard 99. Prefemoral Coeliotomy -- Chelonian 100. Transplastron Coeliotomy -- Chelonian 101. Coeliotomy -- Crocodilian 102. Respiratory Tract 103. Gastro-Intestinal Surgery 104. Urinary Tract 105. Reproductive Tract 106. Cloacal Surgery 107. Amphibian Soft Tissue Surgery 108. External Coaptation 109. Fracture Fixation 110. Spinal Surgery 111. Limb Amputation 112. Tail Amputation 113. Shell Surgery and Repair -- Section 11: Therapy. 114. Therapeutic Overview and General Approach 115. Routes of Administration 116. Antibiotic Therapy 117. Antifungal Therapy 118. Antiviral Therapy 119. Anti-Inflammatory Therapy 120. Anti-Parasitic Therapy 121. Mental Health Treatment 122. Nutritional Therapy 123. Chemotherapy 124. Radiation Therapy 125. Miscellaneous Drug Therapy 126. Allometric Scaling 127. Reptile Formulary 128. Amphibian Formulary 129. Low Level LASER Therapy 130. Wound Management 131. Rehabilitation and Physical Therapy 132. Alternative and Complimentary Therapies -- Section 12: Differential Diagnosis by Clinical Signs. 133. Snakes 134. Lizards 135. Chelonians 136. Crocodilians 137. Amphibians -- Section 13: Specific Disease/ Case Summary. 138. Abscesses 139. Acariasis 140. Regurgitiation and Vomiting 141. Aural Abscess 142. Bites and Prey-Induced Trauma 143. Cloacal Prolapse 144. Cryptosporidiosis (Lizards) 145. Cryptosporidiosis (Snakes) 146. Urolithiasis (cystic calculi, cloacal uroliths) 147. Diarrhea 148. Digit Abnormalities 149. Dysecdysis 150. Dystocia 151. Gout 152. Hemoparasites 153. Hepatic Lipidosis 154. Herpesviruses of Tortoises 155. Hyperglycemia 156. Hyper and Hypovitaminosis A 157. Inclusion Body Disease 158. Secondary Nutritional Hyperparathyroidism 159. Neurologic Disorders 160. Paramyxoviruses 161. Periodontal Disease 162. Pneumonia 163. Pseudogout 164. Renal Disease 165. Shell Damage 166. Salmonellosis 167. Spinal Osteopathy 168. Tail Damage 169. Thermal Burns 170. Stomatitis 171. Scent Gland Adenitis 172. Mycoplasmosis and Upper Respiratory Tract Disease 173. Chytridiomycosis -- Section 14: Population and Public Health. 174. Zoonoses and Public Health 175. Working With Free-Ranging Reptiles 176. Medical Management and Rehabilitation of Sea Turtles 177. Commercial Reptile Farming 178. Large Zoo and Private Collection Management 179. Breeders, Wholesale and Retail 180. Laboratory Reptile and Amphibian Management 181. Conservation Issues 182. Herpetofauna and Ecosystem Health -- Section 15: Legal Topics. 183. International Legislation 184. European Legislation 185. US Federal Legislation 186. Forensics 187. Jurisprudence, Expert Reports, Testimony and Court Appearance.

Growing up -- The beginning of an odyssey -- A plethora of theories -- The scrapie race -- Dr. America and the trembling cannibals -- The battle for tenure -- What's in a name? -- Lost in the Pacific fog -- The amyloid story -- Finding the gene -- Jousting with the press -- Deciphering human prion diseases -- What's in a shape? -- Turf battles -- Mad cow and other prion strains -- Stockholm -- The third judgment of Paris -- Epilogue : the quest for therapeutics.

Magnesium is an essential mineral which is required for growth and survival of humans. Since magnesium is a mineral and not synthesizable it must be obtained through dietary foods and/or supplements. Magnesium in Human Health and Disease reviews the benefits of magnesium supplementation to reach recommended intakes as well as provides new research that suggests how reaching levels above the recommended intakes can promote health and treat various diseases. Magnesium deficiency can cause low serum potassium and calcium levels, retention of sodium, and low circulating levels of regulatory hormones. These changes in nutrients cause neurological and muscular symptoms such as tremor and muscle spasms. Further magnesium deficiency causes loss of appetite, nausea, vomiting, personality changes and death from heart failure. Causes of magnesium deficiency include alcohol abuse, poorly controlled diabetes, excessive or chronic vomiting and/or diarrhea. Thus the effects of inadequate and deficient intakes or levels of magnesium is critical to health and are reviewed by the expert clinicians in this book. Magnesium in Human Health and Disease provides the most current research to support the potential benefits or lack thereof for normal and high supplementation with magnesium. Animal model research and early human trials are reviewed to document other disease states such as hypertension, cholesterol level, type 2 diabetes and cardiovascular disease that would benefit from increased magnesium.

Recently, magnetic nanostructures have gained a remarkable interest for basic research and applied studies. Because of their low cost and ease of manufacture and modification, they have great potential for agricultural and environmental applications. The use of magnetic nanostructures has been proven in a wide range of fields including catalysis, biotechnology, biomedicine, magnetic resonance imaging, agriculture, biosensors, and removal of environmental pollutants, among others. This book includes 16 chapters of collected knowledge, discoveries, and applications in agriculture, soil remediation, and water treatment. It describes the role of nano-agriculture with regard to food security and discusses environmental and agricultural protection concerns. It further offers potential applications of magnetic nanomaterials in the agriculture and food sectors, such as the development of sensors, environment monitoring for wastewater treatment and the remediation of contaminated soils. Increasing crop yield through the use of nanopesticides or nanofertilizers and biosecurity using sensors for detecting pathogens along the entire food chain are discussed as well. This book also brings together various sources of expertise on different aspects magnetic nanostructure application in the agri-food sector and environment remediation. Magnetic nanostructures also have great potential in biotechnological processes, as they can be utilized as a carrier for enzymes during different biocatalytic transformations. Novel magnetic nanomaterials can be used for detection and separation of pesticides from environmental and biological samples. The excellent adsorption capacity of the modified magnetic nanoadsorbents together with other advantages such as reusability, easy separation, environmentally friendly composition, and freedom of interferences of alkaline earth metal ions make them suitable adsorbents for removal of heavy metal ions from environmental and industrial wastes. One of the most important environmental applications of magnetic nanostructures has been in the treatment of water, whether in the remediation of groundwater or through the magnetic separation and/or sensing of contaminants present in various aqueous systems. The integrated combination of these 16 chapters, written by experts with considerable experience in their area of research, provides a comprehensive overview on the synthesis, characterization, application, environmental processing, and agriculture of engineered magnetic nanostructures. Its comprehensive coverage discusses how nanostructure materials interact in plants as well as their potential and useful applications.

This innovative book presents the development and clinical applications of magnetic resonance elastography (MRE), a new MRI-based imaging technology for quantitatively assessing the mechanical properties of tissue. Many disease processes cause profound changes in mechanical characteristics of tissue, but these changes can be completely invisible in examinations with conventional imaging technologies. MRE provides unique tissue information and powerful new diagnostic capabilities. The book begins with an accessible overview of the basic technology underlying MRE. Successive chapters provide coverage of the use of MRE to assess organ systems, including liver, skeletal muscle, brain, lungs, heart, breast, spleen, and kidney. The book is edited by Sudhakar Venkatesh, MD, a leader in the clinical use of this technology, and Richard Ehman, MD, the inventor of MRE. Magnetic Resonance Elastography is a valuable resource for radiologists, residents, fellows, technologists, hepatologists and scientists.

This book describes the roles magnetic resonance imaging (MRI) can play in deep brain stimulation (DBS). DBS therapeutically modulates aberrant neural circuits implicated in a broad range of neurological disorders. Following surgical insertion, an electrode placed into the desired brain target generates constant electricity, analogous to a cardiac pacemaker. Most commonly employed in movement disorders such as Parkinsons disease, dystonia, and tremor, DBS is also being investigated for use in psychiatric and cognitive disorders, including depression and Alzheimers disease. It is estimated that 200,000 patients have undergone DBS surgery worldwide. Imaging techniques, specifically MRI, have played key roles in the preoperative and postoperative aspects of DBS. This book focuses on the established as well as the innovative roles of MRI in DBS. MRI and DBS are first introduced from an historical perspective and a review of the clinical aspects of DBS is performed. Then, the preoperative and postoperative applications of MRI in DBS are covered. The crucial aspect of MRI safety in these patients is also discussed. Finally, possible upcoming MRI applications for patients with DBS are discussed in a future directions chapter. Chapters are written by experts from the University of Toronto, a world leader in the field of DBS, alongside international co-authors to ensure a thorough review of the topics. This is an ideal guide for both clinicians (neurosurgeons, neurologists, psychiatrists, and neuroradiologists) and researchers as well as trainees interested in neuroimaging for DBS.

1. Stem cell tissue engineering and regeneratvie medicine: role of imaging -- 2. Principles and applications of quantitative parametric MRI in tissue engineeering -- 3. High field sodium MRS/MRI: application to cartilage tissue engineering -- 4. SPIO-labeled cellular MRI in tissue engineering: a case study in growing valvular tissues -- 5. Magnetic resonance elastography applications in tissue engineering -- 6. Finite-element method in MR elastography: application in tissue engineering -- 7. In vivo EPR oxygen imaging: a case for tissue engineering -- 8. Tissue-engineered grafts for bone and meniscus regeneration and their assessment using MRI -- 9. MRI assessment of engineered cartilage tissue growth -- 10. Emerging techniques for tendon and ligament MRI -- 11. MRI of engineered dental and crandiofacial tissues -- 12. Osteochondral tissue engineering: noninvasive assessment of tissue regeneration -- 13. Advanced liver tissue engineering approaches and their measure of success using NMR/MRI -- 14. MRI of vascularized tissue-engineered organs -- 15. MRI tools for assessment of cardiovascular tissue engineering -- 16. Peripheral nerve tissue engineering and regeneration ovserved using MRI.

Part I. Histology and Normal Bone Marrow -- Histology of Normal Bone and Bone Marrow, and Their Main Disorders / Reiner Bartl -- MR Imaging of the Normal Bone Marrow and Normal Variants / Bruno C. Vande Berg, P. Omoumi, C. Galant, N. Michoux, and F. E. Lecouvet -- Part II. Bone Marrow Neoplasia -- Haematological Bone Marrow Malignancies / Sung Kim, Kathleen Carrigan, and Michael Mulligan -- MRI of Bone Metastases / Gerwin Paul Schmidt and Andrea Baur-Melnyk -- Multiple Myeloma / Andrea Baur-Melnyk and Melvin D'Anastasi -- MRI for Response Assessment in Oncologic Bone Marrow Lesions / F. Lecouvet, P. Omoumi, A. Larbi, B. Tombal, N. Michoux, B. Vande Berg, and J. Malghem -- Differentiation of Benign and Malignant Vertebral Compression Fractures / Andrea Baur-Melnyk and Tobias Geith -- Part III. Benign Processes Affecting the Bone Marrow -- Diseases of the Reticuloendothelial System / Robert Hemke and Mario Maas -- Anemias and Bone Marrow Insufficiency / Iris-Melanie Noebauer-Huhmann and Martin Uffmann -- Osteonecrosis and Bone Infarction / Anastasia Fotiadou and Apostolos Karantanas -- Bone Marrow Edema Syndrome / Alain Blum, Sophie Lecocq, Matthias Louis, and Pedro Teixeira -- Bone Marrow Changes in Acute and Chronic Trauma / Filip M. Vanhoenacker, Michiel Eyselbergs, and Annick Demeyere -- Infective Inflammatory Bone Disease / Klaus Bohndorf and Hassan Douis -- Non-Infective Inflammatory Bone Marrow Disease / Bernhard J. Tins and Victor N. Cassar-Pullicino -- Part IV. Technical Aspects in Bone Marrow Imaging -- Techniques for Diffusion and Perfusion Assessment in Bone-Marrow MRI / Olaf Dietrich -- Magnetic Resonance Imaging of the Bone Marrow Contrast Media for Bone Marrow Imaging / Daniel Golovko, Elizabeth Sutton, and Heike E. Daldrup-Link.

Instrumentation : magnets, coils, and hardware -- From image formation to image contrast : understanding contrast mechanisms, acquisition strategies, and artifacts -- Contrast agents and relaxation effects -- Disorders of brain development -- Central nervous system manifestations of the phakomatoses -- White matter diseases and inherited metabolic disorders -- Epilepsy -- Adult brain tumors -- Pediatric brain tumors -- Intracranial hemorrhage -- Intracranial vascular malformations and aneurysms -- Cerebral ischemia and infarction -- Head trauma -- Intracranial infection -- Normal aging, dementia, and neurodegenerative disease -- Skull base -- The sella turcica and parasellar region -- Eye and orbit -- Congenital anomalies of the spine and spinal cord : embryology and malformations -- Degenerative disease of the spine -- Neoplastic disease of the spine and spinal cord -- MRI of spinal trauma -- Vascular disorders of the spine and spinal cord -- Spinal infection and inflammatory disorders -- MR angiography : techniques and clinical applications -- MR of fetal brain and spine -- Diffusion and diffusion tensor MR imaging : fundamentals -- Perfusion magnetic resonance imaging -- Psychiatric disorders -- MR spectroscopy and the biochemical basis of neurologic disease -- Functional MRI.

This abundantly illustrated atlas of MR imaging of the knee documents normal anatomy and a wide range of pathologies. In addition to the high-quality images, essential clinical information is presented in bullet point lists and diagnostic tips are included to assist in differential diagnosis. Concise explanations and guidance are also provided on the MR pulse sequences suitable for imaging of the knee, with identification of potential artifacts. This book will be an invaluable asset for busy radiologists, from residents to consultants. It will be ideal for carrying at all times for use in daily reading sessions and is not intended as a reference to be read in the library or in non-clinical settings.

Part 1: Role of MRI in imaging the skeletal musculature: Value of Magnetic Resonance Imaging of the Skeletal Musculature from a clinical point of view -- Correlation of skeletal muscle anatomical to MRI and US findings -- Imaging the skeletal muscle {u2013} when to use MRI and when to use ultrasound -- Part 2: Modern MRI techniques for assessment of the skeletal musculature: Whole-body MRI for evaluation of the entire skeletal system -- Diffusion-weighted and diffusion-tensor imaging: Applications in skeletal muscles -- Assessment of skeletal muscle perfusion using MRI (DCE, ASL, BOLD) -- Skeletal muscle MR imaging beyond protons -- MR spectroscopy and spectroscopic imaging for evaluation of skeletal muscle metabolism: Basics and applications in metabolic myopathies -- Part 3: MRI in the diagnostic work-up of the skeletal musculature: MRI of muscle injuries, such as muscle strains -- MRI in neurogenic myopathies and muscle denervation -- MRI in muscle dystrophies and other myogenic myopathies -- MRI in inflammatory myopathies and autoimmune-mediated myositis -- MRI in muscular channelopathies and myotonias -- MRI in muscle tumours and tumours of the muscle sheaths.

The book encompasses the different concepts and designs using magnets for surgical purposes. It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. The text reviews new data about interventions in all medical and surgical fields. Written by experts in their fields, topics focus on endoluminal and laparoscopic operations, techniques from vascular and GI anastomosis. The book demonstrates the use of magnets to treat a variety of diseases such as reflux, back pain, and fecal incontinence. The reader will learn how to retract and gain exposure, dissect tissue planes, achieve hemostasis, and create anastomosis in a totally different way. Physical properties of external surface and internal magnets are discussed. The authors emphasize the importance of partnering with industry leaders to develop novel surgical tools. By harnessing the power of attraction, the energy and might of magnets, Magnetic Surgery serves as a valuable resource for clinicians, surgeons and researchers in biomedical engineering interested in this form of energy and physical metal properties. In utilizing these properties, the book seeks to improve surgical outcomes of patients worldwide.

This book surveys MEG basics and covers the latest methodological, empirical and clinical research. Includes tutorials on instrumentation, measurement, modeling and experimental design, discussion of open issues, future developments and new applications.

This book reviews all aspects of major depressive disorder (MDD), casting light on its neurobiological underpinnings and describing the most recent advances in management. The book is divided into four sections, the first of which discusses MDD from a network science perspective, highlighting the alterations in functional and structural connectivity and presenting insights achieved through resting state functional MRI and the development of neuroimaging-based biomarkers. The second section examines important diagnostic and neurobiological issues, while the third considers the currently available specific treatments for MDD, including biofeedback, neurofeedback, cognitive behavioral therapy, acceptance and commitment therapy, neuromodulation therapy, psychodynamic therapy, and complementary and alternative medicine. A concluding section is devoted to promising emerging treatments, from novel psychopharmacological therapies through to virtual reality treatment, immunotherapy, biomarker-guided tailored therapy, and more. Written by leading experts from across the world, the book will be an excellent source of information for both researchers and practitioners.

This comprehensive text on flowering trees of tropical gardens discusses some new species of trees, including Adansonia digitata, Monodora myristica, Flacourtia montana, Balanites aegyptiaca, Bursera serrata, Commiphora wightii and Semecarpus anacardium. The text covers more than 200 of the most striking and widespread trees alongside closely related genera and species (both native and exotic) commonly encountered in the tropical climate. It includes more than 700 high resolution coloured photographs, depicting different facets including growth habit, morphological details of stem, leaves, flowers and fruits. The different tree species are organized according to Bentham and Hooker's system of classification of seed plants. The book discusses many aspects of trees including common and botanical names together with synonyms, taxonomic families, etymology (how trees have derived their names), phenology, their native place, geographical distribution, mythological notes, religious significance and economic importance. The text is useful for graduate students and academic researchers in the field of life sciences.

This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completely impossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology in the broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. The second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. The book contains the proceedings of the 12th Uehara International Symposium 2017, "Make Life Visible" sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license. ;

Making Computerized Provider Order Entry Work is neither a scientific reference guide into medical informatics nor a book on theory or a summary of research studies in the field, but rather it is a practical guide to visioning and executing successful automation of physician workflow in the hospital environment. This adaptation of workflow is the work of a team, with leadership, clear vision, dedication, commitment, external drivers, experience, and the tireless work of those before us in this industry, who have paved the way with both successes and failure.Throughout the book, the author shares hard lessons-learned and guides the reader through the early warning signs that will help avoid the pitfalls. As systems progress, and the regulatory environments change, there will be new challenges and opportunities that will confront those setting up automated physician workflows. However, this book highlights and discusses all of the principles involved such as vision, leadership, project management and change management, which will always need to be incorporated to ensure project success. As such this book will be an important reference for anyone involved in the setting up or use of such systems from the physicians and medical professionals themselves through the medical informaticist to health system executives and other decision makers.

Making medicines in Africa : an historical political economy overview / Geoffrey Banda, Samuel Wangwe, Maureen Mackintosh -- Pharmaceuticals in Kenya : the evolution of technological capabilities / Roberto Simonetti, Norman Clark -- Pharmaceutical manufacturing decline in Tanzania : how possible is a turnaround to growth? / Paula Tibandebage, Samuel Wangwe, Maureen Mackintosh -- Bringing industrial and health policies closer : reviving pharmaceutical production in Ethiopia / Tsige Gebre-Mariam, Kedir Tahir, Solomon Gebre-Amanuel -- South-south collaboration in pharmaceuticals : manufacturing antiretroviral medicines in Mozambique / Giuliano Russo, Lâicia de Oliveira -- Can foreign firms promote local production of pharmaceuticals in Africa? / Sudip Chaudhuri -- Raising the technological level : the scope for API, excipients, additives and biologicals manufacture in Africa / Joseph Fortunak, Skhumbuzo Ngozwana, Tsige Gebre-Mariam, Tiffany Ellison, Paul Watts -- Health systems as industrial policy : building collaborative capabilities in the Tanzanian and Kenyan health sectors and their local suppliers / Maureen Mackintosh, Paula Tibandebage, Joan Kariuki Kungu, Mercy Karimi Njeru, Caroline Israel -- The dissemination of local health innovations : political economy issues in Brazil / Erika Aragäao, Jane Mary Guimaräaes, Sebastiäao Loureiro -- Healthy industries and unhealthy populations : lessons from Indian problem-solving / Smita Srinivas -- Policies to control medicines prices : does the South African experience have lessons for other African countries? / Skhumbuzo Ngozwana -- African pharmaceutical standards : the road to improvement and their role in technological capability upgrading / Geoffrey Banda, Julius Mugwagwa, Dinar Kale, Margareth Ndomondo-Sigonda -- Innovative procurement for health and industrial development / Joanna Chataway, Geoffrey Banda, Gavin Cochrane and Catriona Manville -- Industry associations and the changing politics of making medicines in South Africa / Theo Papaioannou, Andrew Watkins, Julius Mugwagwa, Dinar Kale -- Finance and incentives to support the development of national pharmaceutical industries / Alastair West, Geoffrey Banda.

"How did medical students become Galenic physicians in the early modern era? Making Physicians guides the reader through the ancient sources, textbooks, lecture halls, gardens, dissecting rooms, and patient bedsides in the early decades of an important medical school. Standard pedagogy combined book learning and hands-on experience. Professors and students embraced Galen's models for integrating reason and experience, and cultivated humanist scholarship and argumentation, which shaped their study of chymistry, medical botany, and clinical practice at patients' bedsides, in private homes and in the city hospital. Following Galen's emphasis on finding and treating the sick parts, professors correlated symptoms and the evidence from post-mortems to produce new pathological knowledge"-- Provided by publisher.

The first question -- Physics facts that will improve your images -- Screening mammography 101 and beyond -- The recalled patient : now what? findings on mammography -- Breast anatomy and physiology : knowing what's normal -- Calcifications made easy -- Management of masses : BI-RADS 2, 3, or 4? -- Multiple circumscribed masses -- Architectural distortion -- Mammographic asymmetries -- Expanding the differential diagnosis : going beyond IDC-NOS screening detection -- Finding cancers in dense tissue -- Measuring and managing breast cancer risk diagnostic exams/management -- The painful and the palpable -- Evaluation of nipple discharge -- The male breast -- Imaging the patient with breast cancer postoperative studies -- The postoperative breast -- Evaluating women with implants interventions -- Breast needle biopsy : tips for challenging cases.

"This book covers key areas of orthopedic surgery having multiple anatomic sections like: the knee, hip, elbow, hand and wrist, foot and ankle, the pediatric patient, and the spine. Each section is subdivided into specific pathologic conditions eg, the knee section is divided into the major pathologies: the anterior cruciate ligament injuries, posterior cruciate ligament injuries, posterolateral corner injuries, medial-sided injuries, meniscal injuries, patellar instability and osteochondral injuries. As one dissects the anatomy of each topic in a bullet-formatted presentation the classic history, appropriate physical examination tests and pertinent imaging studies are presented, along with evaluation flowcharts, appropriate images (physical examination, radiographic, MRI, CT, and intraoperative findings). For those less familiar with musculoskeletal medicine, we have included algorithms, key references and original videos in each chapter to help the clinician focus on the appropriate areas. Finally, we have outlined what imaging should be obtained, how and when to order it, and how to interpret the results. Our goal was to create a stand-alone reference for all providers from the beginning medical student, technician, physician assistant, or resident to the most senior orthopedic surgeon who may need a quick refresher on the particulars of an examination that he does not routinely perform. We hope that it will be used to solve arguments in clinic and conference regarding the exact maneuvers involved for a particular examination and most importantly, we hope it improves the care that we offer our patients, leading to their correct diagnoses and, ultimately, their best treatment and outcome"--Provided by publisher

Contents -- 1. Affections du tube digestif, avec la collaboration de G. Lauret et P. Olivier-Pallud -- 2. Affections du foie, du pancréas, maladies de la nutrition, parois abdominales, péritoine, avec la collaboration de G. Lauret, Jean Olivier et P. Olivier-Pallud -- 3. Affections de la peau, avec la collaboration de F. Hanoun et G. Vail -- 4. Afections des muqueuses génitales -- 5. Coeur, par H. Vignes et J. Dugas -- 6. Maladies des vaisseaux, avec la collaboration de J. Dugas -- [7.] Eclampsie et eclampsime.

In vitro culturing Plasmodium falciparum erythrocytic stages / Alexander G. Maier and Melanie Rug -- Production of Plasmodium falciparum gametocytes in vitro / Kathryn Shaw Saliba and Marcelo Jacobs-Lorena -- In vitro differentiation of Plasmodium falciparum gametocytes into ookinetes / Anil K. Ghosh and Marcelo Jacobs-Lorena -- Ex vivo culture of Plasmodium vivax and Plasmodium cynomolgi and in vitro culture of Plasmodium knowlesi blood stages / Anne-Marie Zeeman, Annemarie Voorberg-van der Wel, and Clemens H.M. Kocken -- Laboratory maintenance of rodent malaria parasites / Chandra Ramakrishnan [and 6 others] -- Transfection of Plasmodium falciparum / Melanie Rug and Alexander G. Maier -- Transfection of rodent malaria parasites / Nisha Philip, Rachael Orr, and Andrew P. Waters -- Recombination-mediated genetic engineering of Plasmodium berghei DNA / Claudia Pfander [and 4 others] -- Standardization in generating and reporting genetically modified rodent malaria parasites : the RMgmDB database / Shahid M. Khan [and 3 others] -- Transient transfection of Plasmodium vivax blood-stage parasites / Cecilia P. Sanchez [and 3 others] -- Silencing of genes and alleles by RNAi in Anopheles gambiae / Marina Lamacchia [and 5 others] -- Analysis of variant gene family expression by quantitative PCR / Sohini Sanyal, Thomas J. Templeton, and Cristina K. Moreira -- DNA microarray-based genome-wide analyses of Plasmodium parasites / Zbynek Bozdech, Sachel Mok, and Archna P. Gupta -- Whole-genome analysis of Plasmodium spp. utilizing a new Agilent Technologies DNA microarray platform / Heather J. Painter [and 3 others] -- Transcriptome analysis using RNA-seq / Wieteke A.M. Hoeijmakers, Richárd Bártfai, and Hendrik G. Stunnenberg -- Experimental tools for the study of protein phosphorylation in Plasmodium / Dominique Dorin-Semblat [and 4 others] -- Extraction of hydrophilic metabolites from Plasmodium falciparum-infected erythrocytes for metabolomic analysis / Kellen L. Olszewski and Manuel Llinás -- Static and dynamic imaging of erythrocyte invasion and early intra-erythrocytic development in Plasmodium falciparum / David T. Riglar and Jake Baum -- Flow cytometry-based methods for measurement of cytosolic calcium and surface protein expression in Plasmodium falciparum merozoites / Shailja Singh and Chetan E. Chitnis -- Microsphiltration : a microsphere matrix to explore erythrocyte deformability / Catherine Lavazec [and 7 others] -- Atomic force microscopy of Plasmodium-infected red blood cells : detecting and localizing single molecular recognition events / Ang Li [and 3 others] -- Expressing full-length functional PfEMP1 proteins in the HEK293 expression system / Anand Srivastava, Yves Durocher, and Benoît Gamain -- Genome-wide chromatin immunoprecipitation-sequencing in Plasmodium / Jose-Juan Lopez-Rubio, T. Nicolai Siegel, and Artur Scherf -- In situ fluorescence visualization of transcription sites and genomic loci in blood stages of Plasmodium falciparum / Liliana Mancio-Silva and Artur Scherf -- Bioluminescence imaging of P. berghei schizont sequestration in rodents / Joanna Braks [and 5 others] -- Scoring sporozoite motility / Allison F. Carey, Robert Ménard, and Daniel Y. Bargieri -- Quantification of sporozoite invasion, migration, and development by microscopy and flow cytometry / Photini Sinnis [and 4 others] -- Imaging sporozoite cell traversal in the liver of mice / Joana Tavares [and 4 others] -- Analysis of liver stage development in and merozoite release from hepatocytes / Rebecca R. Stanway, Jacqueline Schmuckli-Maurer, and Volker T. Heussler -- Quantitative analysis of Plasmodium berghei liver stages by bioluminescence imaging / Takeshi Annoura [and 4 others] -- Activation of human NK cells by Plasmodium-infected red blood cells / Amir Horowitz and Eleanor M. Riley -- Chimeric parasites as tools to study Plasmodium immunology and assess malaria vaccines / Ian Cockburn -- Development and use of TCR transgenic mice for malaria immunology research / Yun-Chi Chen and Fidel Zavala -- Tracking the total CD8 T cell response following whole Plasmodium vaccination / Katherine L. Doll, Noah S. Butler, and John T. Harty -- Screening inhibitors of P. berghei blood stages using bioluminescent reporter parasites / Jing-wen Lin [and 5 others] -- Screening and evaluation of inhibitors of Plasmodium falciparum merozoite egress and invasion using cytometry / Anthony Bouillon [and 3 others] -- Induction of anti-Plasmodium immunity following subpatent infection with live erythrocytic stages and drug cure / Danielle I. Stanisic and Michael F. Good -- Vaccination using radiation- or genetically attenuated live sporozoites / Ashley M. Vaughan and Stefan H.I. Kappe -- Vaccination using normal live sporozoites under drug treatment / Laurent Rénia [and 3 others] -- Assessing transmission blockade in Plasmodium spp. / Andrew M. Blagborough [and 5 others] -- Mosquito transgenic technologies to reduce Plasmodium transmission / Silke Fuchs, Tony Nolan, and Andrea Crisanti.

Malaria vaccine development : over 40 years of trials and tribulations / Giampietro Corradin & Howard Engers -- Malaria vaccines : reflections on 40 years of basic research and translation applications / Giampietro Corradin -- Challenges for the stakeholders / Howard Engers -- Plasmodium vivax vaccine surrogate markers of protection : dawning of a new era / Mary R. Galinski, Rabindra M. Tirouvanziam & Alberto Moreno -- Plasmodium vivax vaccine development in Colombia : advances and challenges / Myriam Arevalo-Herrera & Sócrates Herrera-Valencia -- Progress towards development of a vaccine for Plasmodium vivax malaria / Ahmad Rushdi Shakri & Chetan E. Chitnis -- Correlates of protection for Plasmodium falciparum malaria vaccine development : current knowledge and future research / James G. Beeson, Freya J.I. Fowkes, Linda Reiling, Faith H. Osier, Damien R. Drew & Graham V. Brown -- Plasmodium falciparum RTS,S vaccines and future development / Tom Egwang -- Plasmodium falciparum pre-erythrocytic vaccines : previous experience and the challenge of selecting new candidates / Thomas L. Richie & Joanne M. Lumsden -- Plasmodium falciparum whole-parasite malaria vaccines / Else M. Bijker & Robert W. Sauerwein -- Index.

This monograph provides specialists and primary care physicians who are interested in hair with the practical know-how needed to achieve successful management of male alopecia. Guidance is first provided on the examination of hair loss in men, covering such aspects as clinical examination, the role of trichoscopy and the trichogram, laboratory work-up, and scalp biopsy. Diagnosis and treatment are then described in depth for a diverse range of conditions involving alopecia. Expert opinion is combined with the results of evidence-based medicine to provide the best current advice, highlighting the synergistic action of combination regimens and adjuvant treatments and explaining the concept of multitargeted treatment. All aspects of follow-up are covered, including compliance issues and expectation management. The role of hair care and cosmetics is also considered, with identification of potential adverse effects as well as benefits.

"This chapter describes techniques for the preparation of human spermatozoa for assisted conception. Traditional swim-up techniques depend on the intrinsic motility of human spermatozoa and have been used as the basis for new microfluidics devices that exploit the capacity of these cells for chemotaxis, rheotaxis or thermotaxis. Unfortunately, such self-migration strategies tend to lose effectiveness with pathological samples exhibiting poor levels of motility and/or diminished counts. With such compromised starting material, active selection of spermatozoa can be achieved by exploiting differences between sperm populations in their density or charge. Density gradient centrifugation selects spermatozoa with minimal residual cytoplasm that are highly motile and have good morphology, even though the induction of sperm DNA damage in certain patients may be problematical. Alternatively, methodologies based on differences in sperm charge, appear to hold promise for the rapid, efficient isolation of highly motile human spermatozoa that consistently exhibit low levels of DNA damage"-- Provided by publisher.

This book provides an up-to-date review of the risk factors and genetics influencing the development of this rare disease. This volume presents clinical features and recent advances in histopathology and molecular profiling are analysed, providing a valuable aid to clinicians in tailoring treatment to both the patient and the tumour. Readers will find important insights into the most effective strategies for making or negating a diagnosis of male breast cancer. Within this timely volume, consideration is also given to the psychological needs of men with breast cancer alongside a discussion of the most effective support methods. The surgical management of the disease is examined, together with algorithms for local and systemic therapy. Owing to the problem of late diagnosis in male breast cancer, many men have advanced or disseminated disease at diagnosis and, as such, the evidence-based management of these cases is reviewed. This book will be of interest to breast surgeons, oncologists, breast radiologists, breast histopathologists and breast care nurses worldwide.

Part 1. Fundamentals -- Embryology and Functional Anatomy of the Male External Genitalia -- Diagnosis -- Fundamentals in Dermatopathology -- Part 2. Non-Infectious Inflammatory Disorders of the Male Genitalia -- Eczematous Dermatoses -- Papulosquamous Dermatoses -- Ulcerative Dermatoses -- Vesicobullous Dermatoses -- Granulomatous Dermatoses -- Part 3. Infectious Disorders of the Male Genitalia -- Nonsexually Transmitted Infections -- Sexually Transmitted Infections -- Part 4. Benign Specialized Disorders of the Male Genitalia -- Pigmentary Lesions/Pigmentary Skin Changes -- Cystic, Nodular, and Papular Lesions -- Vascular Lesions -- Miscellaneous Benign Disorders -- Part 5. Systemic Diseases and the Male External Genitalia -- Systemic Disorders Affecting the Genital Skin -- Part 6. Premalignant and Malignant Disorders of the Male Genitalia -- Premalignant Lesions of the Penis -- Squamous Cell Carcinoma and Secondary Tumors of the Penis and Scrotum -- Nonsquamous Malignant Neoplasms of the Penis and Scrotum.

Now in a revised second edition, this comprehensive text covers all aspects of male hypogonadism from the basic science to clinical management, comprehensively explaining and applying new insights to the treatment of hypogonadal men. Chapters covering neuroendocrine control of testicular function, Leydig cell function, spermatogenesis, and normal and delayed puberty open the book. The focus then turns to the pathophysiology and treatment of hypogonadism and other forms of testicular dysfunction, such as Klinefelter syndrome, cryptorchidism, and disorders of the pituitary, as well as reproductive and endocrine consequences of cancer treatment, environmental factors, obesity and aging. Next are chapters that describe the available options for androgen replacement therapy, and the outcomes when men with hypogonadism of various causes are treated with testosterone, as well as a chapter devoted to current approaches to stimulating spermatogenesis in gonadotropin-deficient men. < Highly practical and updated with the latest available data, this second edition of Male Hypogonadism: Basic, Clinical and Therapeutic Principles cogently presents a large body of scientific information on male reproductive endocrinology to provide a thorough understanding of the pathophysiology, clinical characteristics, and treatments for disorders that adversely affect testicular function.

The book aims to bring into focus the current understanding of male reproduction and the pathological basis of failure to reproduce in men. Infertility in men is a common disorder. However, attempts at scientific study of male infertility are of very recent origin. Many questions about the physiology and pathophysiology of male reproduction are still not clear. The chapters are written by authorities in the field with great clinical experience. The primary focus would be on clinical perspective; however emphasis would also be placed on basic research and molecular biology. .

A groundbreaking contribution to the literature now in its revised and expanded second edition, this textbook offers a comprehensive review of diagnostic and treatment techniques for male infertility. This state-of-the-art, evidence-based textbook incorporates new multidisciplinary and complementary medicine approaches to create a first-of-its-kind guide to treatment strategies for male infertility and beyond. While this new edition is primarily designed as a reference for students and residents in reproductive medicine and andrology, it will be equally useful as well for professionals in urology, reproductive endocrinology, embryology, and research fields who are interested in the role that antioxidants play in male infertility. World-renowned experts in these areas have been selected to participate in this work. Careful selection of the highest quality content will span the whole range of topics in the area of male infertility, providing a complete review of well-established and current diagnostic and treatment techniques for male infertility. The incorporation of 20 new chapters will enhance the books appeal by including the most recent advances brought to the male infertility arena. Additionally, this edition incorporates new features, including bulleted key points, review criteria and select video clips demonstrating some of the most fascinating male infertility treatment modalities. A dedicated new section on current guidelines on male infertility will enlighten readers on how to most optimally manage male infertility clinical scenarios. Covering all aspects of diagnosis and management, ART, lifestyle factors and associated conditions for male infertility, Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants will be a readily accessible, high quality reference for medical students and residents, and will be of significant value to professionals working in the various fields treating this condition as well.

Etiology and pathogenesis / Robert H. Getzenberg and Prakash Kulkarni -- Lower urinary tract symptoms and benign prostatic hyperplasia : epidemiology, correlates, and risk factors / Raymond C. Rosen and Benjamin N. Breyer -- Clinical assessment and diagnosis of lower urinary tract dysfunction (LUTD) : United States / Christopher P. Filson and John T. Wei -- Clinical assessment and diagnosis of LUTS/BPH : Europe / Stavros Gravas and Jean J.M.C.H. de la Rosette -- Clinical assessment and diagnosis of LUTS/BPH : primary care / Matt T. Rosenberg, John Riley, and Marty M. Miner -- Watchful waiting / Reginald Bruskewitz -- Alpha-adrenergic antagonists for lower urinary symptoms secondary to benign prostatic hyperplasia / Nathaly Francois, Raunak D. Patel, Kevin T. McVary -- 5-Alpha reductase inhibitors (5-ARIs) / Claudius, Füllhase, and Roberto Soler -- Anti-muscarinics / Nadir I. Osman and Christopher R. Chapple -- The use of PDE-5 inhibitors in the treatment of lower urinary tract symptoms due to benign prostatic hyperplasia / Casey Lythgoe and Kevin T. McVary -- Combination medical therapy for male LUTS / Claus G. Roehrborn -- Complementary therapy / Aaron E Katz and Anne Darves-Bornoz -- Open simple prostatectomy / Annika Herlemann, Matthias Oelke, and Christian Gratzke -- Minimally invasive therapies / Mauro Gacci, Matteo Salvi, and Arcangelo Sebastianelli -- Holmium laser therapy / Peter Gilling -- Greenlight laser therapy / Alexis E. Te and Bilal Chughtai -- Monopolar and bipolar transurethral resection of the prostate / Aaron M. Bernie and Richard Lee.

Male LUTS/BPH Made Easy is an up-to-date comprehensive reference on the management of Lower Urinary Tract Symptoms (LUTS) due to Benign Prostatic Enlargement (BPE), which incorporates all of the key issues in the field of management of male lower urinary tract symptoms and benign prostatic disease. Male LUTS/BPH Made Easy aims to update the reader on the most current treatments and assist in clinical decision making based on the latest evidence.

This book represents a comprehensive, clinically oriented text covering all aspects of male osteoporosis, from the basic concepts of bone physiology and regulation of bone remodeling in men, the causes and pathophysiological mechanisms responsible for the most frequent causes of osteoporosis, to diagnostic and screening protocols, as well as prevention and treatment approaches. It offers a broad overview of male osteoporosis by specialists involved in research and clinical practice and discusses the practical issues encountered. Filling a gap in the literature, this volume is a valuable resource for general practitioners, clinical endocrinologists, geriatricians and experts in osteoporosis. .

Novel topics compiled in this one-of-a-kind volume provide tantalizing hints for clinical application through future translational research. Only recently have we come to ask what role the male might play in pregnancy loss and embryo implantation failure, beyond contributing an abnormal set of paternal chromosomes at fertilization. This volume explores the recent evidence that these conditions might also be related to the transmission of previously unrecognized chromosomal micro-deletions and duplications, or via the epigenetic dysregulation of early embryonic gene function by spermatozoal microRNAs or alterations in sperm DNA methylation patterning, or by DNA damage secondary to either reactive oxygen species or environmental toxicants. In addition, the composition of seminal plasma has been found to be highly complex, containing many factors that play important roles in altering the uterine environment and the female immune system permissive of embryo implantation and trophectoderm outgrowth leading to successful pregnancy. Coverage includes an examination of both spermatozoa and seminal fluid component factors.

This book aims to offer a comprehensive and up-to-date overview of male stress urinary incontinence that will serve as a useful tool and reference for urologists, andrologists, physiotherapists, general practitioners, and nurses. Detailed information is provided on diagnostic workup, including clinical assessment and the role of urodynamic evaluations and other instrumental examinations, and on the full range of potential treatments, from conservative and pharmacological interventions to surgical options. In addition to careful descriptions of the surgical procedures themselves, clear advice is given on the management of iatrogenic complications of incontinence surgery. Helpful treatment algorithms and recommendations offer further practical support. Relevant background knowledge is provided in expert reviews of topics such as the functional anatomy of the male pelvis and the pathophysiology, epidemiology, and classification of male urinary incontinence.

"In this critical study of current cancer therapies, Dr. Prasad, an oncologist and hematologist, examines oncology practice and policy in the United States. His book is organized into four sections: (1) an overview of cancer drugs, (2) forces that distort cancer medicine and practice, (3) details about cancer research and practice, (4) recommended solutions on multiple levels (policy, practitioners, medical education, and pharmacology)"-- Provided by publisher.

"Cancer can kill: this fact makes it concrete. Still, it's a devious knave. Nearly every American will experience it up-close and all too personally, wondering why the billions of research dollars thrown at the word haven't exterminated it from the English language. Like a sapper diffusing a bomb, Jain unscrambles the emotional, bureaucratic, medical, and scientific tropes that create the thing we call cancer. Scientists debate even the most basic facts about the disease, while endlessly generated, disputed, population data produce the appearance of knowledge. Jain takes the vacuum at the center of cancer seriously and demonstrates the need to understand cancer as a set of relationships--economic, sentimental, medical, personal, ethical, institutional, statistical. Malignant analyzes the peculiar authority of the socio-sexual psychopathologies of body parts; the uneven effects of expertise and power; the potentially cancerous consequences of medical procedures such as IVF; the huge industrial investments that manifest themselves as bone-cold testing rooms; the legal mess of medical malpractice law; and the teeth-grittingly jovial efforts to smear makeup and wigs over the whole messy problem of bodies spiraling into pain and decay. Malignant examines the painful cognitive dissonances produced by the ways a culture that has relished dazzling success in every conceivable arena have twisted one of its staunchest failures into an economic triumph. The intractable foil to American achievement, cancer hands us -- on a silver platter and ready for Jain's incisively original dissection -- our sacrifice to the American Dream"-- Provided by publisher.

This text addresses all aspects of patient evaluation and care. This includes new findings in imaging that provide a better understanding of the extent of the lesion as well as its relationship with critical neuroanatomic function. The evolution of intraoperative imaging, functional brain mapping,and technology to identify tumor from brain is covered. This has significantly improved the ability of surgeons to more safely and aggressively remove tumors.More importantly, a better understanding of tumor biology and genomics has created an opportunity to significantly revise tumor classification and better select optimal therapy for individual patients. The text covers novel and innovative treatment options including immunotherapy, tumor vaccines, antiangiogenic agents,and personalized cancer treatment. In addition, novel agent delivery techniques are covered to offer the potential for increasing the effectiveness of treatment by delivering active agents directly where they are needed most. Malignant Brain Tumors: State-of-the-Art Treatment provides a comprehensive overview of treatment for malignant gliomas, and will prove useful by updating physicians on new therapeutic paradigms and what is on the horizon for the near future. This text will be informative for surgeons, oncologists, neurologists, residents and students who treat these patients,as well as those who are training for a career in managing patients with these challenging tumors. .

This book covers different aspects of the rare neoplasms - malignant mesothelioma and pseudomyxoma peritonei. The monograph includes up-to-date information on etiology, pathogenesis and diagnostics of malignant mesothelioma and pseudomyxoma peritonei, as well as detailed description of surgical and combined treatment of patients with these diseases. The book comprises a large illustrative material presented by schemes and original micrographs that represent pathological and immunohistochemical specific features of these malignancies, demonstrate the stages of surgical operations and hyperthermic intraperitoneal chemotherapy, and show the results of experimental studies. The book includes validated discussion on etiology and pathogenesis of malignant mesothelioma and pseudomyxoma peritonei, differential diagnosis and treatment of these diseases. The scope is really extensive and involves, for instance, a description of the technique of cytoreductive surgeries and regimens of intraperitoneal hyperthermic chemoperfusion, whereas a particular section discusses experimental ground for optimal regimens of hyperthermia, local chemotherapy and adoptive immunotherapy by cytokine induced killers. The final section presents the most recent data about perspective approaches for immunotherapy of malignant mesothelioma and pseudomyxoma peritonei with cell based technologies and target drugs including inhibitors of immune checkpoints. The co-authors of the book are leading specialists in this area, surgeons and scientists who present the results of their research along with the analysis of the state-of-the-art of this problem. The book is designed for a wide audience of students and professors of medical universities and schools, specialists of research and diagnostic centers, practical oncologists and immunologists, as well as doctors of different medical areas. .

Signs and symptoms -- Diagnostic Studies of Pediatric Bone Tumors: Pathology and Imaging -- Basic Principles of Biopsy -- The evaluation of lung nodules in pediatric bone tumors -- Fertility Preservation and Reproductive Health in Pediatric Bone Tumor Patients -- Chemotherapy Regimens for Patients with Newly Diagnosed Malignant Bone Tumors -- Radiation Management -- Histologic Response and Biologic Markers -- Surgical Approach: Limb Salvage Versus Amputation -- Rehabilitation following Orthopaedic Surgery in Children with Bone Tumors -- Patient Navigation of the Pediatric Bone Tumor Patient Across the Continuum of Care -- Psychosocial Effects of Pediatric Bone Tumors and Recommendations for Supportive Care -- Post-therapy surveillance of bone tumors -- Recurrent Bone Tumors -- Novel Therapies on the Horizon -- Survivorship.

This book provides essential information on recent advances in molecular genetics, epidemiology, translational research, and the latest results of clinical trials on mesothelioma. Significant progress has been made in understanding mesothelioma biology, and in developing new therapies for this refractory tumor, malignant pleural mesothelioma (MPM). Not only does this volume summarize the latest research-based data on the disease; it also shares insights into future research directions. The book consists of 5 themed sections on: epidemiology, pathogenesis, screening and early detection, molecular genetics, and clinical aspects and management. Several chapters focus on new trends in the field, e.g. immune therapy and identification of biomarkers, molecular oncogenesis including genetic susceptibility, and molecular diagnostic pathology. The book also highlights new cancer treatment approaches, such as immunotherapy based on immune checkpoint inhibitors, which has meant a paradigm shift in other types of cancer, and given some hope to MPM patients. In turn, it discusses recent molecular pathological studies on mesothelioma, which claim to offer more accurate classifications than traditional morphology and immunohistochemistry-based approaches. All of these cutting-edge analyses provide the basis for a closing discussion on future developments and research directions. Malignant Pleural Mesothelioma -- Advances in Pathogenesis, Diagnosis, and Treatments has been edited and authored by respected researchers and will be of interest to medical, surgical and radiation oncologists; pulmonologists; pathologists and basic researchers alike. Since the disease represents a significant diagnostic and therapeutic challenge, scientists and clinicians from learners to experts, as well as fellows in training in these subspecialties, will value this book.

This book is a comprehensive analysis of the definitions, concepts, and recent research on malingering, feigning, and other response biases in psychological injury/ forensic disability populations. It presents a new model of malingering and related biases, and develops a "diagnostic" system based on it that is applicable to PTSD, chronic pain, and TBI. Included are suggestions for effective practice and future research based on the literature reviews and the new systems, which are useful also because they can be used readily by psychiatrists as much as psychologists.

This book comprehensively educates psychiatrists about malpractice and other liability. It is written to also specifically assist psychiatrists who are sued or are involved in other complaints. The first two sections discuss malpractice law and the litigation process; the litigation section mainly addresses some of the more emotionally charged issues, including do's and don'ts, how an attorney will be looking at the case, the defendant doctor's testifying at deposition and trial, and the stress of being sued. The subsequent three sections address specific topics that give rise to liability, with each section taking a different perspective such as risks in particular clinical, by practice site, and special issues, including practice in special situations such as the current pandemic. The final section discusses other forms of liability, such as complaints to medical boards or professional association ethics committees. An exceptional work, Malpractice and Liability in Psychiatry, functions as both a go-to handbook and all-encompassing read on the aforementioned topics.

Principles of medical malpractice -- Errors, incidents and complications in general surgery -- Retained surgical foreign bodies -- Quality management related to wrong-site surgery -- Towards a preventive safety culture within the hospital -- Ethical aspects of an open safety culture : towards a new physician-patient relationship in 21st century medicine.

Providing a comprehensive presentation of the diagnosis, evaluation and management of malunions, this generously illustrated text details the current principles, surgical techniques and approaches with these challenging clinical situations. Since each malunion can be fairly specific, the treatment regimens provide guidelines to effectively approach such problems. Opening with a brief overview of the principles of malunions, the remainder of the book is divided by anatomical area and provides evidence-based recommendations, case examples, and preferred treatment/algorithms for both the upper and lower extremities, including the clavicle, proximal and distal humerus, hand and wrist, proximal and distal femur, and tibia and ankle, as well as the pelvis and acetabulum. Specialized circumstances are also discussed, including periprosthetics and joint replacement. Although not every single treatment option is described for every single anatomical area and type of injury, Malunions is an excellent resource for orthopedic trauma surgeons, residents and students, not only for managing these common yet complex problems but also in preventing malunions from occurring by avoiding surgical causes and mitigating patient risk factors.

Studying recombination in mouse oocytes / Xianfei Sun and Paula E. Cohen -- Analysis of recombinants in female mouse meiosis / Esther de Boer, Maria Jasin, and Scott Keeney -- Studying meiosis-specific cohesins in mouse embryonic oocytes / Ji-hye Kim [and others] -- Immunohistochemical approaches to the study of human fetal ovarian development / Jing He [and others] -- Protein kinase assays for measuring MPF and MAPK activities in mouse and rat oocytes and early embryos / Jacek Z. Kubiak -- Time-lapse epifluorescence imaging of expressed cRNA to cyclin B1 for studying meiosis I in mouse oocytes / Janet E. Holt, Simon I.R. Lane, and Keith T. Jones -- Using FRET to study ranGTP gradients in live mouse oocytes / Julien Dumont and Marie-Hélène Verlhac -- Making cRNA for microinjection and expression of fluorescently tagged proteins for live-cell imaging in oocytes / Mark Levasseur -- RNAi-based methods for gene silencing in mouse oocytes / Paula Stein, Petr Svoboda, and Richard M. Schultz -- Micro-injection of morpholino oligonucleotides for depleting securin in mouse oocytes / Petros Marangos -- Measuring transport and accumulation of radiolabeled substrates in oocytes and embryos / Jay M. Baltz, Hannah E. Corbett, and Samantha Richard -- Immunofluorescence staining of spindles, chromosomes, and kinetochores in human oocytes / Solon Riris [and others] -- Studying the roles of aurora-C kinase during meiosis in mouse oocytes / Kuo-Tai Yang [and others] -- Chromosome spreads with centromere staining in mouse oocytes / Jean-Philippe Chambon, Khaled Hached, and Katja Wassmann -- Preparation of mammalian oocytes for transmission electron microscopy / Lynne Anguish and Scott Coonrod -- Measuring Ca² oscillations in mammalian eggs / Karl Swann -- Counting chromosomes in intact eggs / Teresa Chiang and Michael A. Lampson -- Free-hand bisection of mouse oocytes and embryos / Zbigniew Polanski and Jacek Z. Kubiak -- Microarray-CGH for the assessment of aneuploidy in human polar bodies and oocytes / Souraya Jaroudi and Dagan Wells -- Nuclear transfer in the mouse oocyte / Eiji Mizutani, Atsuo Ogura, and Teruhiko Wakayama.

v. 1. TRPs: truly remarkable proteins -- The TRCP subfamily -- TRPC1 -- TRPC2 -- TRPC3: a multifunctional signaling molecule -- TRPC4 and TRPC4-containing channels -- TRPC5 -- TRPC6: physiological function and pathophysiological relevance -- Transient receptor potential canonical 7 (TRPC7) -- The TRPV subfamily -- TRPV1 -- TRPV2 -- TRPV3 -- The TRPV4 channel -- TRPV5, a Ca2+ channel for the fine tuning of Ca2+ reabsorption -- TRPV6 channels -- The TRPM subfamily -- TRPM1 -- TRPM2 -- TRPM3 -- TRPM4 -- TRPM5 -- TRPM6 -- TRPM7 -- TRPM8 -- The TRPA1, TRPML and TRPP subfamily -- TRPA1 -- TRPML1: an ion channel in the lysosome -- TRPML2 and mucolipin evolution -- TRPML3 -- TRPP subfamily and polycystin-1 proteins -- v. 2. TRPs as special cell sensors -- Temperature sensing with TRPs -- TRPs in mechano-sensing and volume regulation -- TRPs as chemosensors (ROS, RNS, RCS, gasotransmitters) -- Photosensitive TRPs -- TRPs in taste and chemesthesis -- TRPs and Pain -- TRPs in hearing -- TRPs in olfaction -- General topics -- Evolutionary conserved, multitasking TRP channels-lessons from worms and flies -- Structural biology of TRP channels -- High-resolution views of TRPV1 and their implications for the TRP channel superfamily -- Physiological functions and regulation of TRPC channels -- The TRPCs-STIM1-orai interaction -- The TRPC family of TRP channels: roles inferred (mostly) from knockout mice and relationship to ORAI proteins -- TRPs: modulation by drug-like compounds -- TRP channels in reproductive (neuro)endocrinology -- Modulation of TRP ion channels by venomous toxins -- Phosphoinositide regulation of TRP channels -- TRP modulation by natural compounds -- What do we really know and what do we need to know: some controversies, perspectives, and surprises.

Introduction -- The man who crucified himself -- The storia della crocifissione as an epistemic genre -- Making the case travel, translation, media, reading -- Professional readings: religion -- Professional readings: madness -- Professional readings: suicide -- Popular readings: moral education through literary -- Epilogue.

"This book contains a series of chapters on various aspects of management and leadership in a health care organisation, written by some of the most experienced authors from around the world. It provides an understanding of basic management and leadership skills that are essential for clinical as well as non-clinical staff in a health care organisation, in a simple and clear fashion. The topics covered in this book range from preparing for an interview, the art of negotiation and handling difficult behaviour, to clinical leadership, evidence based management, mentorship, and conflict resolution. With its simple and reader friendly approach this unique and concise book will be useful for all staff working in a health care organisation irrespective of their faculty, position, and stage in career in becoming successful consultants, managers, supervisors, and leaders."--From the publisher.

Management and Leadership for Nurse Administrators, Seventh Edition provides professional administrators and nursing students with a comprehensive overview of management concepts and theories. This text provides a foundation for nurse managers and executives as well as nursing students with a focus on management and administration. This current edition includes 15 chapters, framed around the Scope and Standards for Nurse Administrators, American Organization of Nurse Executive competencies, and current trends in healthcare management. The American Nurses Credentialing Center.s focus on magnetism is also integrated into this edition, specifically on transformational leadership, structural empowerment, exemplary professional practice, innovation and improvement, and quality. -- Provided by publisher.

"Management and Leadership for Nurse Administrators, Eighth Edition provides professional administrators and nursing students with a comprehensive overview of management concepts and theories. This text serves as a solid foundation for nurse managers, executives and students focused on management and administration. The Eighth Edition will address a number of new topics such as financial management as it relates to reimbursement as well as updates to the Affordable Care Act as they become known. In addition, the text will also include new content on population health, the IHI quadruple aim, and translational science. Other topic areas that will be addressed in-depth include: strategic planning, communication, relationship-building, work force diversity, team building and joy in the workplace. New to the Eighth Edition New content on management strategies for mentoring and coaching a diverse nursing staff Coverage of conflict resolution, risk mitigation and leadership skill developmentDiscussion of the business of health care, resource procurement and financial viabilityEthics as it relates to patient care delivery, research and quality improvement Retention strategies Updated chapter references Crosswalks for major content areas and competencies from AONE, ACHE and other professional organizationsInstructor Resources: Test bankPowerPoint Slides Discussion questionsSyllabusTransition guideCase ExemplarsCase Studies"--Provided by publisher.

Recognizing that medical faculty face different questions or issues in different stages of their careers, this handy, practical title offers a comprehensive roadmap and range of solutions to common challenges in the complex and changing Academic Medical Center (AMC). With critical insights and strategies for both aspiring and seasoned academicians, this handbook offers a concise guide for personal career development, executive skill acquisition, and leadership principles, providing actionable, targeted advice for faculty seeking help on a myriad of new issues and situations. Pressures in today's Academic Medical Center include significant changes to the healthcare system, competition for research funding, transformation of medical education, and recruitment and retention of the ever-evolving workforce. This dynamic environment calls for razor-sharp leadership and management effectiveness to stay competitive. AMC faculty aspire to formal leadership roles for a variety of reasons: to set a new vision, to create change, or to affect policy and resource decisions. For others, weariness of past leadership styles or mistakes may catalyze wanting a chance to set a different tone. Management and Leadership Skills for Medical Faculty: A Practical Handbook is a must-have resource for faculty in AMCs and anyone with a role in healthcare leadership. .

This comprehensive, up-to-date guide to the rehabilitation care of persons with spinal cord injuries and disorders draws on the ever-expanding scientific and clinical evidence base to provide clinicians with all the knowledge needed in order to make optimal management decisions during the acute, subacute, and chronic phases. A wealth of information is presented on the diverse medical consequences and complications encountered in these patients and on the appropriate rehabilitative measures in each circumstance. The coverage encompasses all forms of spinal cord injury and all affected organ systems. Readers will also find chapters on the basics of functional anatomy, neurological classification and evaluation, injuries specifically in children and the elderly, and psychological issues. The book will be an invaluable aid to assessment and medical care for physicians and other professional personnel in multiple specialties, including physiatrists, neurosurgeons, orthopedic surgeons, internists, critical care physicians, urologists, neurologists, psychologists, and social workers.

This comprehensive, up-to-date guide to the rehabilitation care of persons with spinal cord injuries and disorders draws on the ever-expanding scientific and clinical evidence base to provide clinicians with the knowledge needed in order to make optimal management decisions during the acute, subacute, and chronic phases. The second edition re-organized contents as more clinically practical use, consisting of 48 chapters. Also, new chapters such as kinesiology and kinematics of functional anatomy of the extremities are added as well. Readers will also find chapters on the basics of functional anatomy, neurological classification and evaluation, injuries specifically in children and the elderly, and psychological issues. The book will be an invaluable aid to assessment and medical care for physicians and other professional personnel in multiple specialties, including physiatrists, neurosurgeons, orthopedic surgeons, internists, critical care physicians, urologists, neurologists, psychologists, and social workers.

1. A brief history of obstetric complications -- 2. Spontaneous abortion complications -- 3. Pathological diagnosis of abortions -- 4. Tubal pregnancy -- 5. Non-tubal ectopic pregnancies: diagnosis and management -- 6. Adnexal pathology in pregnancy -- 7. Fibroid complications in pregnancy -- 8. Cervical pregnancy -- 9. Molar and trophoblastic disease -- 10. Assisted reproductive technique complications in pregnancy -- 11. Spontaneous uterine rupture prior to twenty weeks of gestation -- 12. Cervicoisthmic incompetence -- 13. Thrombophilia and pregnancy -- 14. Diabetes in pregnancy -- 15. Hypertensive disorders of pregnancy -- Index.

This book draws on recently acquired knowledge to provide the reader with comprehensive, up-to-date information on the full range of obstetric complications that may be encountered during the third trimester of pregnancy and puerperium. For each complication, risk factors and clinical presentation are described and detailed guidance is provided on the appropriate treatment. The lucid text is complemented by a wealth of images, diagrams, flow charts, and drawings. The volume has been compiled in collaboration with a large group of gynecologists, obstetricians and internationally renowned scientists to provide an essential guide. Accordingly, the book is of interest to practitioners across the world, enabling them to deepen their knowledge and to refine their approach to complications in daily clinical practice. .

Hernia repair is one of the commonest operations in general surgery. Open or laparoscopic repair of a primary inguinal hernia is a relatively straightforward operation, but more complex abdominal wall hernias demand greater surgical skill and knowledge. The editors have assembled the world's top herniologists to describe and illustrate numerous surgical techniques in detail. The field of herniology has developed rapidly over the last few years. Since the previous edition of this book, published in 2003, new surgical techniques have been developed and many new prosthetic and biologic materials have been introduced. Management of Abdominal Hernias 4e presents an authoritative, comprehensive and fully updated account of the surgical techniques and the available prosthetic materials for performing repair of abdominal wall hernias. Both open and laparoscopic methods are included. It is aimed at general and specialist surgeons in the practice of clinical surgery, as well as trainee surgeons.

This book is designed to present a comprehensive and state-of the-art approach to the management of adrenal neoplasms that provides a resource to the broad group of providers that will encounter such a patient. Sections address issues that are faced by providers who encounter a patient with an adrenal neoplasm. These areas include an overview of the genetic basis and familial cancer syndrome-associated with adrenal neoplasms, pathobiology, advanced and tumor specific imaging approaches and technologies, biochemical analysis, standard medical and surgical therapies, and emerging technology and treatment approaches to benign and malignant adrenal neoplasms. Written by experts in the field, each of these sections address level of clinical evidence and provide recommendations and treatment algorithms. Extensive illustrations make this an interactive text. Management of Adrenal Masses in Children and Adults will serve as a very useful resource for all providers dealing with, and interested in this common but challenging tumor. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.

Overview of traumatic brain injury / Erin D. Bigler, William L. Maxwell -- Medical evaluation / David B. Arciniegas -- Neuropsychological assessment / Rodney D. Vanderploeg -- Disorders of consciousness / John Whyte, Joseph Giacino -- Cognitive impairments / David B. Arciniegas, Kimberly L. Frey, and Thomas W. McAllister -- Disorders of mood and affect / Ricardo E. Jorge, David B. Arciniegas -- Anxiety disorders / Jesse R. Fann, Matthew Jakupcak -- Posttraumatic stress disorder / Jan E. Kennedy, Michael S. Jaffee, and Douglas B. Cooper -- Posttraumatic psychosis / Perminder S. Sachdev -- Aggressive disorders / Stuart C. Yudofsky, Jonathan M. Silver, and Karen E. Anderson -- Apathy / Robert van Reekum, Emma van Reekum -- Substance use disorders / Jennifer Bogner -- Headache / Robert L. Ruff [and others] -- Seizures and epilepsy / Lauren Frey -- Sleep and fatigue / Sandeep Vaishnavi, Una McCann, and Vani Rao -- Posttraumatic sensory impairments / Nathan D. Zasler -- Traumatic brain injury in late life / William C. Walker, David X. Cifu -- Athletes and sports-related concussion / Christopher M. Bailey, Michael A. McCrea, and Jeffrey T. Barth -- Military personnel and veterans with traumatic brain injury / Kimberly Meyer, Michael S. Jaffee -- Persistent symptoms after a concussion / Jonathan M. Silver, Thomas Kay -- Forensic issues and traumatic brain injury / Robert P. Granacher Jr.

This textbook summarizes the state of the art in the management of locally advanced and metastatic prostate cancer with the aim of providing the knowledge required for optimal treatment decision making in individual cases. Readers will find comprehensive coverage of the latest developments in surgery, radiotherapy, androgen deprivation therapy (ADT), chemotherapy, and immunotherapy. The role of the hormonal therapies abiraterone and enzalutamide and docetaxel-based chemotherapy in castration-resistant prostate cancer and hormone-sensitive metastatic disease is carefully evaluated. Among the other therapies discussed are LHRH agonists and antagonists, cabazitaxel, radium-223, and various novel agents still under clinical trials. The section on surgical approaches addresses, among other topics, the use of robot-assisted radical prostatectomy, pelvic lymphadenectomy, and the benefits of adjuvant and neoadjuvant therapy. The current role of external beam radiotherapy, alone or in combination with ADT and brachytherapy, for locally advanced disease is reviewed. Management of Advanced Prostate Cancer will be a valuable resource for practitioners at all levels of expertise.

This book is designed to provide a foundation of knowledge regarding the epidemiology, pathogenesis, and clinical presentation of atopic dermatitis in both pediatric and adult patients. It provides an overview of the mechanism and presentation of atopic dermatitis and focuses on the management methods experienced dermatologists have used to successfully manage atopic dermatitis. This book provides physicians with insights into the management of atopic dermatitis, such as alternative treatments for pruritus, psychosocial impact on patients and families, assessing patient compliance, and patient resources. This book also: Provides proven strategies for treating atopic dermatitis Helps providers create a treatment plan for their atopic patients Aids physicians in developing techniques for assessing patient compliance Thoroughly addresses the significant economic and psychosocial impact of atopic dermatitis.

1. Biliary system anatomy, physiology, and embryology -- 2. Primary sclerosing cholangitis -- 3. Commentary: primary sclerosing cholangitis -- 4. Biliary manifestations of chronic pancreatitis -- 5. Commentary: biliary manifestations of chronic pancreatitis, critical uncertainties, controversies, and future considerations -- 6. Autoimmune pancreatitis -- 7. Counterpoint: biliary manifestations in autoimmune pancreatitis -- 8. Recurrent pyogenic cholangitis -- 9. Commentary: recurrent pyogenic cholangitis -- 10. Proximal biliary stricutres mimicking hilar cholangiocarcinoma -- 11. Counterpoint: proximal biliary strictures mimicking hilar cholangiocarcinoma -- 12. Traumatic biliary stricutres -- 13. Commentary: traumatic biliary strictures, comprehensive management of benign biliary stenosis and injury -- 14. Perceptual errors leading to bile duct injury during laparoscopic cholecystectomy -- 15. Commentary: perceptual errors leading to bile duct injury during laparoscopic cholecystectomy -- 16. The heuristics and psychology of bile duct injuries -- 17. Commentary: the heuristics and psychology of bile duct injuries -- 18. The classification and injury patterns of iatrogenic bile duct injury during laparoscopic cholecystectomy -- 19. Commentary: the classification and injury patterns of iatrogenic bile duct injury during laparoscopic cholecystectomy -- 20. Bile duct injuries and the law -- 21. Commentary: bile duct injuries and the law -- 22. Intraoperative management of bile duct injuries by the non-biliary surgeon -- 23. commentary: intraoperative management of bile duct injuries by non-biliary surgeon -- 24. Management of bile duct injuries within the first forty-eight hours -- 25. Commentary :Management of bile duct injuries within the first forty-eight hours -- 26. Endoscopic management of bile duct injury during laparoscopic cholecystectomy -- 27. Role of intervational radiology in managing bile duct injuries -- 28. Operative repair of common bile duct injury -- 29. Commentary: Operative repair of common bile duct injury -- 30. Management of isolated sectoral duct injury -- 31. Commentary: Management of isolated sectoral duct injury -- 32. Liver resection for bile duct injury -- 33. Commentary: Liver resection for bile duct injury -- 34. Liver transplantation for common bile duct injury -- 35. Commentary: Liver transplantation for common bile duct injury -- 36. Biliary stricutres from liver transplantation -- 37. Commentary: Biliary strictures from liver transplantation -- 38. Recurrent biliary strictures after initial biliary reconstruction.

The biceps tendon is one of the most challenging anatomic structures to completely understand. Its precise role for shoulder function has yet to be completely defined, and pathologic conditions exist at both its proximal and distal ends. In recent years, the biceps labral complex has been recognized as a common cause of shoulder pain among patients. Accurate diagnosis, utilizing both physical examination and imaging, is crucial to decision-making regarding the most effective treatment. Many controversies exist surrounding the management of biceps pathology with a myriad of potential solutions to consider. This practical text breaks down the biceps into succinct, digestible portions with expert tips and tricks to help manage bicipital problems in a wide array of patients. Sensibly divided into three thematic sections, it encompasses all aspects of the biceps tendon, including relevant anatomy, diagnosis, imaging, and non-operative management (including rehabilitation and biologic treatments). Surgical management strategies as they pertain to both proximal and distal biceps tendon pathologies will be covered, including both arthroscopic and open tenodesis, transfer, and inlay and onlay fixation methods. A review of associated complications and how to avoid them is likewise described in detail, along with post-surgical rehabilitation techniques to maximize return to play. Ideal for orthopedic surgeons and sports medicine specialists at all levels, The Management of Biceps Pathology will be a unique resource for all clinicians facing challenges treating the active patient with shoulder and elbow pain.

This book provides a single, comprehensive reference source that incorporates the epidemiology, natural history, and the latest genetic and molecular biological findings of bladder cancer. This book discusses the diagnostic and staging evaluation of both non-muscle invasive and invasive bladder cancer and incorporates the new findings on markers for the diagnosis of bladder cancer. Risk stratified treatment of non-muscle invasive bladder cancer including various approaches to intravesical therapy are reviewed. Current guideline-based approaches to management and new data regarding diagnosis and prognostication of muscle invasive bladder cancer is analyzed and summarized. This book covers the application of chemotherapy for muscle invasive and advanced disease. The evidence-based application of multimodality therapy is highlighted. Gaps in current knowledge and important areas for clinical research are highlighted. Authored by experts in their respective fields, Management of Bladder Cancer: A Comprehensive Text with Clinical Scenarios serves as an easy and complete reference source for clinicians, researchers, individuals in training, allied health professionals and medical students in the fields of Urology, Medical Oncology, Radiation Oncology, Basic and Translational Science and Epidemiology.

This latest edition provides a comprehensive, state-of-the-art overview of the major issues specific to managing bleeding patients. Like the previous edition, the sections of this new edition have been structured to review the overall scope of issues, among them bleeding associated with disease condition, bleeding from specific organs, bleeding associated with medication, and bleeding associated with procedures. In addition to thoroughly revised and updated chapters from the previous edition, the latest edition features new chapters on such topics as the basics of hemostasis, bleeding due to rare coagulation factor deficiencies, bleeding associated with connective tissue disorders, massive transfusion protocol, bleeding associated with ventricular assist device, and evaluation of bleeding risk prior to invasive procedures. The volume also includes brief etiology and a practical reference guide regarding type of blood components, medication, dose, and duration. Written by authors from a variety of integrated disciplines, Management of Bleeding Patients, Second Edition is a valuable resource for clinicians working in the area of bleeding management.

This pocket guide provides a concise yet comprehensive overview of the two most prominent clinical features of multiple myeloma (MM), bone disease and renal failure. The first half of the text reviews critical aspects of bone disease in MM, including pathophysiology, the use of imaging modalities and drugs in treatment, and the role of orthopedic surgery in MM. The latter half of the book reviews major components of kidney disease in MM, from pathophysiology to treatment. Written by experts in the field, Management of Bone Disease and Kidney Failure in Multiple Myeloma: A Pocket Guide is a valuable resource for clinicians and practitioners who manage patients afflicted with multiple myeloma.

This book offers evidence-based clinical knowledge of older patients suffering from breast cancer. It details the full armament of therapeutic options as well as the epidemiology of the disease and specific psychosocial considerations for elderly patients.

A significantly expanded third edition, this book provides a comprehensive and concise overview of cardiac arrhythmias and their ECG/telemetry manifestations, including the principles of cardiac electrophysiology, current concepts of pharmacology, clinical features, diagnoses, and state-of-the-art treatments. Additionally, the book emphasizes decision-making strategies in approaching each individual patient and the application of technical innovations in specific clinical situations. Organized into eight parts, beginning chapters introduce the concepts and principles of cardiac electrophysiology, unique rhythms, and ECG waves/signs. These chapters are designed to integrate emerging knowledge in basic science and clinical medicine. Subsequent chapters focus on the diagnosis of a variety of cardiac arrhythmias using non-invasive methodology. Throughout the book, chapters continue to analyze pharmacological and other approaches to therapy of specific arrhythmias, including supraventricular tachycardias, atrial fibrillation and flutter, ventricular arrhythmias, and bradyarrhythmias. Finally, the book closes with coverage on inherited cardiac arrhythmia syndromes including the long, short QT, and J-wave syndromes, catecholaminergic polymorphic ventricular tachycardia, and arrhythmogenic right ventricular cardiomyopathy. The third edition of Management of Cardiac Arrhythmias, is an essential resource for physicians, residents, fellows, and medical students in cardiology, cardiac surgery, vascular surgery, cardiac electrophysiology, and cardiac radiology.

"This book summarizes the great progress in the treatment of cardiovascular disease (CVD). Due to improved therapies, preventive strategies and increased public awareness, CVD mortality has been on the decline for both genders. Unfortunately, the decline has been less prominent for women, and CVD remains the leading cause of mortality for women in the United States and is responsible for a third of all deaths of women worldwide. Management of Cardiovascular Disease in Women provides a comprehensive overview of differences in cardiac problems in women including the challenges and limitations of the available literature. Unique aspects to women's heart health such as pregnancy, the impact of emotional stress and other psychosocial issues are discussed by leading experts in the field. They therefore provide important insight to cardiovascular care in women, making this book an essential resource for a wide range of practitioners including cardiologists, primary care providers, internists, and reproductive healthcare professionals."--Publisher's website.

This volume provides new data about the molecular biology of CRPC and a review of the definition, staging and prognostic factors that define CRPC. The book features an in-depth review of proven therapeutic options, including bone-targeted therapies, immunotherapy, chemotherapy and hormonal based therapies. Combination therapy as well as novel targeted approaches presently under investigation are also reviewed. The text provides up-to-date guidelines and algorithms for the management of CRPC based on international guidelines presently available as well as evidence-based medicine. As a concise yet comprehensive summary of the current status of the field, Management of Castration Resistant Prostate Cancer serves as a very useful resource for physicians and researchers dealing with this challenging malignancy.

This important title brings together a distinguished panel of thought-leaders, known for their insights into the development and application of minimally-invasive surgical and endovascular techniques, to provide a comprehensive and discerning compendium of our most current knowledge and state-of-the-art procedures in the management of cerebral vascular diseases. Written in a style that is accessible to students and experienced practitioners alike, the book covers all the important recent advances that have reshaped the field in dramatic ways. Emphasizing how surgical and endovascular techniques are complementary, the volume includes illuminating chapters on the nexus of endovascular and conventional "open" cerebrovascular surgery, including patient assessment and practice in a hybrid operating environment, utilizing the best methods to achieve optimal outcomes. A major addition to the clinical literature, Management of Cerebrovascular Disorders: A Comprehensive, Multidisciplinary Approach will be of significant interest to neurosurgeons, neurologists, neuroradiologists, neurointensivists, students, residents, fellows, and specialized attending physicians.

1. Introduction -- 2. The physiology and pharmacology of nausea and vomiting induced by anticancer chemotherapy in humans -- 3. First-generation 5-HT3 receptor antagonists -- 4. Palonosetron -- 5. The role of neurokinin-1 receptor antagonists in CINV -- 6. Olanzapine for the prevention of chemotherapy-induced nausea and vomiting -- 7. Gabapentin for the prevention of CINV -- 8. Prevention of CINV in patients receiving high-dose multiple-day chemotherapy -- 9. Clinical management of CINV -- 10. Treatment of chemotherapy-induced nausea -- 11. Conclusions -- 12. Future directions.

This book provides a comprehensive, state-of-the-art overview of chest trauma. The text reviews all aspects of chest wall, intra-thoracic organ, and great vessel injury management, with each section of the book structured anatomically to explore specific treatment options. Since injury care alone is insufficient in guiding the totality of care, the text features a robust section on inpatient critical care, which includes cutting edge evidence on resuscitation, advanced monitoring, and organ system support. The book also contains a section on disaster and mass casualty events, focusing on specifics of treatment, ethics of resource allocation, and the role of specialized centers. Written by experts in the field, Management of Chest Trauma: A Practical Guide is a valuable resource for clinicians and practitioners who treat patients afflicted with injuries to the chest.

The Challenge of Chronic Diseases -- Some Alternative Schemes for the Management of Chronic Diseases -- Difficulties in Implementing Effective Management -- Redefining Conditions for the Effective Management of Chronic Diseases -- Activities Specific to an Effective Management of Chronic Diseases -- Dynamic Processes for the Provision of Efficient Care -- Lump Sum Funding, Efficiency and Development -- An Illustration -- From Processes to Organizational Structures -- Contractual Relationship Configurations -- Implementation Strategy -- IS in Health System Restructuring.

This book presents a comprehensive and instructive management plan for physicians who care for CKD patients. Basic aspects of CKD, clinical assessment, evaluation and management of risk factors, cardiovascular disease in the context of CKD, assessment and management of CKD complications, special circumstances in CKD patients, and the path to renal replacement therapy are all thoroughly covered. Diagnostic and therapeutic approaches are presented according to the latest staging system for CKD, with patient care being discussed separately for each disease stage. The proposed management plan is both 'best available evidence based' and 'practice based'. The book also recognizes the needs of busy clinicians by including helpful boxes summarizing the evidence on diagnostic and therapeutic issues and practice pearls based on guidelines. The authors are recognized experts from across the world, ensuring global coverage of the problem, and most have participated in writing guidelines on CKD.

Distress, adjustment and anxiety disorders / Daniel McFarland and Jimmie Holland -- Depression in cancer care / Daisuke Fujisawa and Yosuke Uchitomi -- Diagnosis and treatment of demoralization / David W. Kissane -- Recognizing and managing suicide risk / Maggie Watson and Luigi Grassi -- Psychopharmacologic management of anxiety and depression / Madeline Li, Joshua Rosenblat, and Gary Rodin.

The risk of cancer increases with age and the number of older adults seeking treatment is rising dramatically in line with the aging population. The care of older patients differs from that of younger adults because of variation in the biology of the tumor, age-related variation in host physiology, co-morbidity burden and psychosocial issues, which might impact the efficacy and side effects of cancer therapy. Management of Colorectal Cancers in Older People focuses on treatment strategies of colorectal cancers and provides guidance on the issues specific to older patients, spanning background and epidemiology, special considerations in the care of older people, therapeutics, and psychosocial considerations. This book offers a thorough review of current approaches to treating older colorectal cancer patients, detailing the special issues and considerations involved. The discipline-spanning coverage outlines best practice and proposes topics for future research. The third volume in the Management of Cancer in Older People series, this book will be of interest to all surgical oncologists, medical and radiation oncologists, gerontologists, proctologists and other members of the multidisciplinary team involved in the care of elderly colorectal cancer patients.

Hyperlipidemia / Vien T. Truong [and 5 others] -- Hypertension / Udho Thadani, Nguyen Duc Cong -- Stable coronary artery disease / Mohammed Haris Umer Usman [and 5 others] -- Acute coronary syndrome / Udho Thadani, Quang Tuan Nguyen, Han Yaling -- ST segment elevation myocardial infarction / Runlin Gao [and 7 others] -- Heart failure / Dan D. Le [and 5 others] -- Decompensated heart failure / Patrick Campbell [and 5 others] -- Atrial fibrillation / Mihail Chelu [and 7 others] -- Ventricular tachycardia / Sorin Lazar [and 5 others] -- Syncope / Rajasekhar Nekkanti [and 5 others] -- Aortic stenosis / Rajiv Goswami, Phillip Tran, Nguyen Lan Hieu, Aravinda Nanjundappa, Neal Kleiman -- Mitral regurgitation / Raj Nekkanti [and 6 others] -- Cardiovascular problems in the older patients / Daniel Forman, Nanette Wenger -- Cardiovascular problems in women / Kahroba Jahan, Nisa Arshad, Nguyen Phuc Nguyen, Ainol Shareha Sahar, Amsa Arshad, Kwan Lee.

"In community settings, the most common barriers to independent living, employment, and stable interpersonal relationships for patients suffering from schizophrenia-spectrum disorders or other psychotic disorders are negative symptoms and cognitive deficits. In contrast, severely mentally ill individuals, often incarcerated or chronically institutionalized, more frequently experience substantial barriers related to positive psychotic symptoms leading to problematic behaviors such as aggression or violence. This is not to say that among the chronically institutionalized severely mentally ill population that positive psychotic symptoms are the only, or even majority, source of problematic behaviors. A survey conducted within the California Department of State Hospitals, a circa 7000-bed system dedicated to the treatment of conserved and forensically committed patients, reviewed 839 episodes of aggression or violence by 88 persistently aggressive inpatients and found that 54% of such episodes were impulsive, 39% were predatory or instrumental, and 17% were psychotically driven. Nevertheless, amelioration or control of positive psychotic symptoms commonly forms the initial treatment focus among the severely mentally ill."-- Provided by publisher.

The diversity of procedures that characterize modern refractive surgery makes it, both for the beginner and the experienced surgeon, necessary to have well established guidelines to face refractive complications. This lavishly illustrated guide is written by international opinion leaders with extensive experience in the practice of refractive surgery. It offers the reader practical pearls to the solution and prevention of the different complications of corneal and refractive surgery. This book provides ophthalmic surgeons with appropriate solutions for the most frequent problems they would face in their daily practice. Surgical complications are described and illustrated from their pathogenesis to various treatment modalities. Complications covered include: Intraoperative complications (e.g. those encountered during femtosecond laser, SMILE and LASIK, corneal refractive surgery, refractive lens exchange, and intraocular refractive procedures); early post-operative complications and late post-operative complications. This illustrated guide is written by international opinion leaders with extensive experience in the practice of refractive surgery. Devoted to refractive complications, it provides ophthalmic surgeons with the most adequate solutions for the most frequent problems.

This book describes the challenges that deep carious lesions pose for dental practitioners, including the risk of endodontic complications and the difficulty of restorative treatment, and identifies options for overcoming these challenges on the basis of the best available evidence. The opening chapter sets the scene by discussing pathophysiology, histopathology, clinical symptomatology, and treatment thresholds. The various treatment options are then systematically presented and reviewed, covering non-selective, stepwise, and selective carious tissue removal and restoration, sealing of lesions using resin sealants or crowns, and non-restorative management approaches. In each case the current evidence with respect to the treatment is carefully evaluated. Advantages and disadvantages are explained and recommendations made on when to use the treatment in question. Illustrative clinical cases and treatment pathways for clinicians are included. This book will be of value for all practitioners who treat dental caries and carious lesions, whether in the permanent or the primary dentition. It will also be of interest to under- and postgraduate students in cariology and restorative, operative, preventive, and pediatric dentistry.

This book explores the challenges of treating foot complications associated with diabetes,℗ℓ a major challenge for societies the world over. Authors include experienced podiatrists, nurses and doctors,℗ℓ all of whom℗ℓ work in the field of diabetes foot care. The book is divided into prevention and early management, management of major complications, prevention of recurrence and how to structure a team.℗ℓ In each area, the authors describe their practical experiences and discuss how they have addressed clinical challenges. Management of Diabetic Foot Complications provides useful information for anyone responsible for the care of people with diabetes who may be at risk of developing foot complications.

The burden of diabetes : emerging data / Maffi, P., Secchi, A. -- The eye as a window to the microvascular complications of diabetes / Zerbini, G., Maestroni, S., Turco, V., Secchi, A. -- Emerging insights into pathogenesis / Midena, E., Pilotto, E. -- Emerging issues for optical coherence tomography / Pierro, L., Rabiolo, A. -- Optical coherence tomography angiography in diabetic maculopathy / Coscas, G., Lupidi, M., Coscas, F. -- Emerging issues for ultra-wide field angiography / Rabiolo, A. [and 6 others] -- Emerging simplified retinal imaging / Sharma, A. -- Intravitreal ranibizumab in diabetic macular edema : long-term outcomes / Zucchiatti, I., Bandello, F. -- Intravitreal aflibercept in diabetic macular edema : long-term outcomes / Introini, U., Casalino, G. -- Intravitreal steroids in diabetic macular edema / Lattanzio, R., Cicinelli, M.V., Bandello, F. -- Practical lessons from protocol I for the management of diabetic macular edema / Mukkamala, L., Bhagat, N., Zarbin, M.A. -- Practical lessons from protocol T for the management of diabetic macular edema / Mukkamala, L., Bhagat, N., Zarbin, M.A. -- Is laser still important in diabetic macular edema as primary or deferral therapy? / Battaglia Parodi, M., Bandello, F. -- Anti-vascular endothelial growth factor injections : the new standard of care in proliferative diabetic retinopathy? / Li, X., Zarbin, M.A., Bhagat, N. -- Surgical management and techniques / Codenotti, M., Iuliano, L., Maestranzi, G. -- Enzymatic vitreolysis for vitreomacular traction in diabetic retinopathy / Rizzo, S., Bacherini, D. -- Diabetic macular edema : emerging strategies and treatment algorithms / Moisseiev, E., Loewenstein, A. -- Application of clinical trial results to clinical practice / Zarbin, M.A., Bhagat, N., Mukkamala, L.

This book provides a rapid overview of crosslinking protocols and the therapeutic guidelines to optimize the application according to patients age and ectasia staging. This book is unique in the field of crosslinking therapy, as it gives the readers a complete guide for their daily practice to understand the modern accelerated crosslinking protocols, indications and customized treatment strategies. Ophthalmic specialists, opticians, optometrists and doctors working in ophthalmic settings, will find this book to be a 'go-to' guide for furthering clinical knowledge of this specialized treatment for early progressive corneal ectasia.

Breast cancer, its causes, early detection and treatment have received considerable attention, since this widespread disease is one of the most important health concerns for women. This book provides a comprehensive overview of the diagnostic and therapeutic aspects of the management of early-stage breast cancer, including essential information on basic topics like pathology, and radiology, as well as the latest developments. Further, it discusses all aspects of surgical care, chemotherapy and radiation therapy, together with the controversies and current management guidelines. Helping readers acquire a deep, holistic understanding of the topic, the book is a valuable resource for practitioners and postgraduate students in the field of gynecologic oncology. Moreover, it is a useful aid to decision-making in day-to-day practice for oncologists, residents, fellows and experienced practitioners.

This practical reference book provides up-to-date, evidence-based multidisciplinary guidelines on the epidemiology, biology, diagnosis, and treatment of endometrial cancer. Individual chapters focus on topics such as hormonal interactions, cancer prevention, genetic classification and its clinical applications. Recent advances in diagnostic methods are described. The treatment-oriented chapters include coverage of the roles of lymphadenectomy and sentinel node dissection, surgical complications, radiation techniques, and chemotherapy in early-stage disease. Treatment options in advanced disease, including hormonal therapy and targeted therapy, are considered separately, as is the management of rare tumor types. The authors are international key opinion leaders. Summaries of the ESMO/ESGO/ESTRO guidelines on management are included. Each clinical chapter ends with a summary of recommendations with the level of evidence.

Anatomical Borders of the Parotid Region -- Extended Parotid Tumors with Origin in the Parotid Tissue -- Extended Parotid Tumors with Origin in the Parotid Lymph Nodes -- Extended Parotid Tumors with Origin in the Skin of the Head and Neck -- Parotid Tumors with Skin Extension -- Parotid Tumors with Muscle Extension -- Parotid Tumors Extended in the Facial Bones -- Parotid Tumors Extended in the Base of Skull -- Pathological Variety of Extended Parotid Tumors -- Clinical Diagnosis of Extended Parotid Tumors -- The Diagnostic Imaging of Extended Parotid Tumors -- Extended Parotidectomy -- Issues on General Anesthesia -- Arising Problems in Extended Parotidectomy -- Closing Postoperative Defects by Direct Suture -- The Use of Local Muscular Flaps -- The Use of Musculo-Cutaneous Platysma Flaps -- The Use of Muscular or Musculo-Cutaneous Pectoralis Major Flap -- The Use of Musculo-Cutaneous Latissimus Dorsi Free Flap -- The Use of Fascial-Cutaneous Radial Flap -- Attitude Toward the Facial Nerve in Extended Parotidectomy.-The Management of Lagophthalmos in Facial Nerve Paralysis -- The Value of Lipostructure in Extended Parotidectomy -- Issues on Radiotherapy -- Chemotherapy in Extended Parotidectomy.

In this book, leading European shoulder experts review the current status in the management of failures of surgical treatment of different pathological conditions around the shoulder, such as instability of the glenohumeral joint and the acromioclavicular joint, rotator cuff disease and pathology of the long head of the biceps tendon, and glenohumeral osteoarthritis. The aim is to equip readers with clear guidance on how to manage such failures in everyday practice. There is a particular focus on all aspects of the management response to failure of shoulder arthroplasty. Information is provided on the reasons for failure of the various procedures, and key points on controversial topics are highlighted. Furthermore, case examples are used to present challenging scenarios and their possible solutions. The numerous high-quality illustrations aid comprehension, and readers will also have access to supplementary online videos. The book, published in cooperation with ESSKA, will be invaluable for orthopaedic surgeons and highly relevant for other medical and health practitioners such as sports medicine doctors, physical medicine doctors, and physical therapists.

1. Anatomy -- 2. Physiology and Pathophysiology -- 3. Diagnosis and Imaging -- 4. Endoanal Ultrasound -- 5. MR -- 6. Anorectal Manometry -- 7. Electromyography -- 8. Pelvic Floor Rehabilitation -- 9. Radiofrequency (SECCA procedure) -- 10. Sacral Nerve Stimulation -- 11. Bulking agent and perspectives -- 12. Artificial Bowel Sphincter -- 13. Anal Sphincter Reconstructions and Replacements -- 14. Stoma -- 15. Stem Cells.

Management of Functional Gastrointestinal Disorders in Children presents biopsychosocial theory with respect to six groups of functional disorders: disorders of elimination, vomiting disorders, abdominal pain, infant colic, chronic non-specific diarrhea of infants and toddlers, and failure to thrive. It illustrates, through numerous clinical examples, concepts of management developed during 45 years of practice. A satisfactory clinical outcome for pediatric gastrointestinal disorders often depends on the clinician's ability to discern not only the biological factors in illness, but also the unique cognitive and emotional needs that patients bring to the task of healing. This book provides guidelines for integrating the biopsychosocial model, an approach that has been under-emphasized in the literature until now. It includes naturalistic descriptions of functional gastrointestinal disorders, clinical goals, and the theoretical bases for management techniques. Offering numerous real-world examples and tips, this book serves as a valuable resource for pediatricians, family practitioners, pediatric mental health practitioners, pediatric nurse practitioners, as well as pediatric gastroenterologists.

Pulses have played a major role in human diet and are considered a rich source of proteins. But, the major constraints in achieving the yield of pulses are the occurrences of various diseases and pests. Hence, there is a need to understand major fungal pathogens and their management strategies for sustainable agriculture. The major pulse crops in India and other Asian countries are bengal gram, pigeon pea, black gram, green gram, lentil and peas, which are attacked by several pathogens that cause considerable crop damage. Bengal gram is affected mainly by wilt (Fusarium oxysporum f. sp. ciceri), blight (Mycosphaerella pinodes) and rust (Uromyces ciceris-arietini). The main diseases of pigeon pea are wilt (Fusarium oxysporum) and Phytophtora stem blight (Phytophthora drechsleri f. sp. cajani). Powdery mildew (Erysiphe polygoni) and rust (Uromyces vicia-fabae) are the most important diseases affecting the production of pea. This volume offers details like symptoms, distribution, pathogens associated, predisposing factors and epidemiology, sources of resistance and holistic management of diseases with particular reference to those of economic importance. Several minor diseases of lentil, green gram and of black gram are discussed with their detailed and updated information. This volume provides pooled information regarding the management of major fungal phytopathogens affecting pulses. .

This book provides a comprehensive state-of-the-art overview on the established knowledge in the field of gastroesophageal reflux disease (GERD) as well as a current insight into new algorithms involving new diagnostic tools and new endoscopic and surgical techniques. The integration of these new findings in updated therapeutic decision making is demonstrated. The book reviews the latest literature on new diagnostic findings to better discriminate between different benign disorders of the esophagus and stomach. It describes the decision making to establish indications for the variety of established and new therapeutic options in the management of the disease. It also describes in detail new therapeutic techniques, which provides excellent back-up information for every clinician in daily practice. Management of Gastroesophageal Reflux Disease is a valuable resource for clinicians, surgeons, nurses, technicians, students and researchers with an interest in esophageal and upper GI- disease.

This book is especially focused on the surgical aspect on Gender Dysphoria. Male to female surgery is widely discussed as well as the female to male conversion. Full information on hormone administration and surgical procedures are provided. Mental health issues are also described, as well as ethics, the law and psychosocial issues. The text is extensively referenced and includes numerous photos, tables and figures to clearly illustrate information. Based on collaboration between international experts in transgender health, this book is an essential guide for health care professionals, educators, students, patients and patients? families concerning the psychological, hormonal, surgical and social support of transgender individuals.

The risk of cancer increases with age and the number of older adults seeking treatment is rising dramatically in line with the aging population. The care of older patients differs from that of younger adults because of variation in the biology of the tumor, age-related variation in host physiology, co-morbidity burden and psychosocial issues, which might impact the efficacy and side effects of cancer therapy.Management of Gynecological Cancers in Older Women focuses on treatment strategies of gynecological cancers and provides guidance on the issues specific to older patients, spanning background and epidemiology, special considerations in the care of older women, therapeutics, and psychosocial considerations. This book offers a thorough review of current approaches to treating older gynecological cancer patients, detailing the special issues and considerations involved. The discipline-spanning coverage outlines best practice and proposes topics for future research.The second volume in the Management of Cancer in Older People series, this book will be of interest to all surgical oncologists, medical oncologists, gerontologists, gynecologists and other members of the multidisciplinary team involved in the care of elderly gynecological cancer patients.

This book provides a simple, step-by-step guide to the identification and sequential management of vascular lesions in the body. Since most vascular lesions occur in the head and neck area, the surgical interventions present challenges with regard to facial growth, airway management and reconstruction options. This book explores the treatment of head and neck vascular malformations and tumors from the perspectives of various specialties, such as otolaryngology, and pediatric, maxillofacial and plastic surgery. It covers surgical anatomy, pathophysiology, molecular basis, medical treatment, current embolization guidelines and surgical resection and reconstruction options for each type of tumor. It also discusses interventional and diagnostic radiological techniques. Written by leading international specialists, the book is a valuable resource for craniofacial, pediatric, maxillofacial, head and neck, and plastic surgeons as well as pediatricians and otolaryngologists.

This book is a comprehensive review for practitioners of all persuasions involved in the management of patients with heart failure. Heart failure is a problem of epidemic proportions in all parts of the world. State of the art treatment may not be accessible to all, but simply creating an awareness of simple methods of diagnosis and treatment would assist in promoting a better global response to this epidemic. This revised edition, written by a panel of world-renown cardiology experts, focuses on the medical management of heart failure and outlines the causes, etiopathology and mechanisms in such a way that most health care professionals can grasp the concepts. The book details the common investigations, clinical profiles and therapeutic paths required of all clinicians with these patients under their care. Management of Heart Failure - Volume 1: Medical will be essential reading for all specialists dealing with patients with or who are at risk of heart failure, including but not limited to cardiologists, emergency medicine physicians, critical care physicians, interventionalists, physician assistants, nurse practitioners, advanced practice nurses and cardiac surgeons. Volume 2: Surgical will be essential reading for all specialists dealing with patients with or who are at risk of heart failure, including but not limited to cardiologists, emergency medicine physicians, critical care physicians, anesthesiologists, interventionalists and cardiothoracic surgeons.

This book focuses on the management of hematological cancer and provides guidance on the management issues specific to older patients, spanning background and epidemiology, special considerations in the management of older people, therapeutics and psychosocial considerations. Management of Hematological Cancers in Older People aims to provide an up-to-date review of the literature in each of the major areas relating to the management of older hematological cancer patients, and makes recommendations for best practice and future research. The authors come from a broad geographic spread including the UK, mainland Europe and North America to ensure a worldwide relevance. Management of Hematological Cancers in Older People will appeal to surgical oncologists, medical oncologists and other members of the multidisciplinary team.

This book provides a comprehensive review of the clinical management of hereditary colorectal cancer. The text focuses on six distinct patient groups: patients with elderly age-of-onset colorectal cancer and adenomas, patients with hamartomatous colorectal polyps, patients afflicted with familial adenomatous polyposis (FAP), patients with attenuated familial adenomatous polyposis (AFAP), patients with MYH associated polyposis (MAP), and patients afflicted with lynch syndrome (LS). Each chapter illustrates how clinicians utilize current technologies in genetic testing, pathological review, and endoscopic, surgical, and chemotherapeutic/immunotherapeutic approaches to manage these patient groups. Topics such as the timing of genetic testing, endoscopic screening and surveillance, prophylactic surgical options and chemo-preventive interventions are also discussed in concise yet precise detail. Written by experts in their fields, Management of Hereditary Colorectal Cancer: A Multidisciplinary Approach is a valuable and timely resource for gastroenterologists, surgeons, genetic counselors, medical oncologists, psychologists, and any health caregivers involved with the management of patients and families afflicted with a hereditary form of colorectal cancer. .

Management of High Altitude Pathophysiology presents a comprehensive overview on the various therapeutic practices and ongoing research relating to the development of more potent and novel formulations for managing high altitude pathophysiology. It provides a detailed application of both herbal and non-herbal therapeutic agents, including their nanoformulations. This important reference provides benefits to the medical and herbal scientific communities, doctors treating patients with high altitude complications, individuals travelling to high altitudes for recreation or work, and scientists working on future drug development.

This book provides a comprehensive, state-of-the-art review of the concepts vital to a modern treatment of common and opportunistic infections in the immunocompromised host. Chapters are written by experts in the field, and include their views on gaps in the field and future directions of research. This book begins with an overview of the normally functioning immune system followed by a detailed discussion of the major primary immunodeficiencies. Specific chapters are dedicated to providing practical knowledge in the prevention and treatment of infections in specific immunocompromised patients, including those with cancer, transplant recipients, HIV infection, and autoimmune disorders. Emphasis is placed on diagnostic evaluation, antimicrobial selection that includes consideration of the threat of antimicrobial-resistant pathogens, and immunotherapy tailored to specific patients. Finally, dedicated chapters on stem cell transplantation for patients with primary immunodeficiencies, adoptive cellular immunotherapy, and gene therapy will provide readers with insight into these rapidly evolving and cutting edge therapies. Management of Infections in the Immunocompromised Host is a valuable resource for infectious diseases specialists, immunologists, oncologists, hematologists, general physicians, students, researchers, and all other working with immunocompromised patients.

This handbook provides a concise, state-of-the-art overview on the management of inflammatory bowel disease (IBD) in the hospitalized patient. The book reviews epidemiology and risk factors for hospitalization in patients with ulcerative colitis (UC) and Crohns disease, as well as medical and surgical management strategies for patients hospitalized with UC or Crohn's disease. The book also highlights complex disease management cases involving co-infection from clostridium difficile and/or CMV. The volume also spotlights nutrition management, quality of care, and management of pediatric and pregnant patients hospitalized with IBD flares.

This book is a rich source of practical guidance on the management of relatively young patients with osteoarthritis of the knee that will assist physicians and allied health professionals in enabling patients to remain active and sustain their quality of life. It provides up-to-date knowledge on the available treatment options, describes the evidence base for each option, and identifies the appropriate timing and indications. The book opens by considering the basic science behind osteoarthritis, which is critical to management. The many nonsurgical treatment modalities are then discussed, with particular focus on the importance of a multidisciplinary approach. Subsequent chapters address the role of surgical management, covering both techniques that attempt to preserve and possibly restore the native knee joint, such as meniscal and chondral surgery, arthroscopic debridement, and osteotomy for realignment of the joint, and those that involve joint replacement. The arthroplasty component of the text encompasses all areas of prosthetic resurfacing, including localized resurfacing, unicompartmental replacement, and total knee replacement. The book has been produced in cooperation with ISAKOS and the authors constitute an international faculty who provide a truly global perspective on the subject.

This book is designed to present a comprehensive understanding for the rationale of neoadjuvant treatment sequencing for localized pancreatic cancer and to focus on accurate clinical staging and stage-specific treatment sequencing. Sections address important aspects of clinical management of localized pancreatic cancer from diagnosis to surgery. These areas include initial radiographic staging, management of obstructive jaundice, role of chemotherapy and chemoradiation in neoadjuvant therapy, assessment of treatment response, and operative considerations for complex vascular resections. A brief review of suggested readings addressing the particular topic follows in each section, as well as a summary of clinical "pearls". Management of Localized Pancreatic Cancer: Current Treatment and Challenges provides a comprehensive resource which clearly defines the principles of neoadjuvant therapy as well as a clinical framework for successful therapy. It serves as a valuable guide to physicians of multiple disciplines who are interested in utilizing neoadjuvant therapy for localized pancreatic cancer.

This book aims to provide an up-to-date review of the literature in each of the major areas relating to the management of older lung cancer patients, and makes recommendations for best practice and future research. The authors come from a broad geographic spread including the UK, mainland Europe and North America to ensure a worldwide relevance.

Sub- or preretinal hemorrhage involving the macula is a typical complication in a variety of ocular diseases, including age-related macular degeneration, arterial macroaneurysm, Valsalva retinopathy, and trauma. However, there is currently no consensus regarding the ideal treatment for macular hemorrhage. The purpose of this book on macular hemorrhage is twofold: it aims both to impart valuable information on pathophysiology, risk factors, diagnostic aspects, and prognostic criteria under different conditions and to provide a systematic overview of therapeutic approaches that cover the most important situations a vitreoretinal surgeon might encounter when treating patients with this disorder. Case presentations, clinical photographs, and an extensive review of the literature supplement the important information on clinical decision making, surgical techniques, and typical pitfalls and invite the reader to explore the advantages and disadvantages of various approaches to the management of macular hemorrhage.

While the management of meniscal pathology is addressed in many large sports medicine textbooks, this dedicated book on the topic is a major addition to the information currently available for orthopedic surgeons and sports medicine specialists, residents and fellows. As symptomatic meniscal tears remain among the most common musculoskeletal problems that are seen and treated, this up-to-date book on the evaluation and management of meniscal pathology, focused on current techniques and available evidence in the literature, is therefore extremely useful. To that end, The Management of Meniscal Pathology: From Meniscectomy to Repair and Transplantation is a comprehensive resource reviewing all aspects of managing symptomatic meniscal pathology. It is structured to proceed logically through an understanding of the anatomy and biomechanical importance of the meniscus in normal knee kinematics to the evaluation and treatment of meniscal tears and meniscal insufficiency. The chapters dedicated to the surgical management of meniscal pathology - including partial meniscectomy, meniscus repair, meniscal root repair and meniscal allograft transplantation - include step-by-step descriptions of various operative techniques, including pearls and pitfalls for the reader in addition to classic case examples. Non-operative approaches, as well as novel and emerging strategies and materials, are also highlighted, providing a well-rounded presentation of available techniques and outcomes.

This book provides a systematic review of the management and treatment of this disease. The concise and highly structured chapters feature essential background knowledge and commentary on recent advances within each step of a range of patient pathways. Management of Muscle Invasive Bladder Cancer provides a framework for patients' care based on the research, as well as practically and clinically oriented guidelines. This book is relevant to trainees and practicing urologists and oncologists, in addition to medical professionals involved in the treatment of bladder cancer.

Management of Musculoskeletal Injuries in the Trauma Patient summarizes the most current concepts and clinical practices for the management of the patient with musculoskeletal traumatic injuries. The text covers optimal time frames for stabilization of orthopedic injuries and strategies to mitigate systemic injury while minimizing damage due to pelvic, spine and long bone trauma. The volume covers the gamut of traumatic axial and extremity injuries, including cervico-lumbar-thoracic spine injuries, spinal cord injuries, long bone fractures with special emphasis on the femoral shaft, pelvic and acetabular injuries, open fractures, mangled extremities, upper extremity injuries, combination and severe soft tissues injuries and periarticular fractures. These are discussed in the context of isolated injury and combined with orthopedic injuries of the brain, abdomen, chest and other musculoskeletal injuries. Written by internationally recognized experts, Management of Musculoskeletal Injuries in the Trauma Patient is a valuable resource for orthopedic surgeons.

This book pursues a multidisciplinary approach, presenting chapters with updated information on various aspects of treatment for patients with neuroendocrine tumors. Authors have been selected from expert centers in Europe and the United States. The goal of this book is to comprehensively summarize recent data and provide inspiring ideas to optimize the care of patients with neuroendocrine tumors. Neuroendocrine tumors are fascinating multifaceted diseases that can primarily localize in many organs with various presentations. These tumors are rare but their increasing incidence renders likely that physicians caring for cancers may have either already faced or may be certainly exposed to diagnose and/or treat a patient with neuroendocrine tumors. Over the last years, novel therapeutic options have emerged for neuroendocrine tumors, profoundly challenging practices that had previously been the standards for decades. These include - but are not limited to - somatostatin analogues, targeted therapies such as tyrosine kinase and mTOR inhibitors, antiangiogenic compounds, but also peptide-receptor targeted therapy or radioembolization. This changing field has generated novel treatment algorithms to guide medical decisions. To better understand and handle the multidisciplinary approaches that are required for optimizing the care of neuroendocrine tumor patients, physicians are now looking for references from experts and comprehensive reviews summarizing current knowledge on treatments for patients with neuroendocrine tumors.

This book covers the latest advances in non-muscle invasive bladder cancer care. It provides a review of the available evidence base for the efficacy of a range of therapeutic techniques, diagnostic procedures and risk factors. Management of Non-Muscle Invasive Bladder Cancer features detailed guidance in uniformly formatted chapters on how to properly apply a range of available therapeutic treatments relevant for patient care. It is a valuable resource for all trainee and practising medical professionals who treat these patients.

This book covers the management of various metabolic, nutritional and hormonal complications that arise after bariatric surgery. Until now bariatric surgeons have focused on mastering the surgical technique and reducing surgical complications. A number of metabolic and nutritional complications in the post-surgical phase can remain undiagnosed or unreported with a potential for irreversible morbidity. The book is edited by a team of experienced surgeons and bariatric nutritionists to provide a balanced perspective on the subject. It includes chapters on the prevention and subsequent diagnosis and management of these complications early in the course and explaining each complication with one or more suitable case reports. This book is relevant for practicing as well as aspiring bariatric surgeons, nutritionists/dieticians and bariatric physicians.

This book provides comprehensive information on the etiology, pathophysiology, medical implications, diagnosis, and surgical and nonsurgical treatment of obstructive sleep apnea (OSA). Divided into five parts, the book begins with principles and fundamentals of OSA and its diagnostic considerations. Subsequent parts then address non-surgical management, surgical management, and maxillomandibular advancements for OSA. Chapters seek to approach this common disorder from the viewpoint of multiple specialties, thereby promoting the development of a broad strategy for the evaluation and management of OSA patients that draws on each of them. An invaluable reference, Management of Obstructive Sleep Apnea: An Evidence-Based, Multidisciplinary Textbook meets the needs of advanced dental and medical students, orthodontic, maxillofacial, ENT, neurology, and plastic surgery residents, and sleep medicine and pulmonary physicians.

This book provides a concise, state-of-the-art overview of occult GI bleeding. The text reviews the epidemiology, screening and detection methods for localization, and prominent treatment strategies for occult GI bleeding. It also features a dedicated section on special patient populations including children, premenopausal women, older adults, and patients with other predisposing, and complicating medical conditions. This volume is supplemented with numerous color illustrations, photographs, and table, and is one of the few dedicated resources on occult GI bleeding. Written by experts in the field, Management of Occult GI Bleeding: A Clinical Guide is a valuable resource for clinicians, practitioners, and students who are involved in the treatment of patients with occult GI bleeding.

This book uses a unique case-based approach to review the intra-operative and peri-operative management of patients with severe ocular trauma and open globe injuries. The case- based structure of this text allows readers to easily reference the type of injury they are treating in order to assist with management of their patients and to recognize indications to involve other ophthalmic and surgical specialties in the management of patients with open globe injuries. Management of Open Globe Injuries will be an indispensable resource for ophthalmologists who are called upon to care for patients who have suffered open globe trauma.

Tumor biology varies at different subsites in the oral cavity, and therefore carcinoma of the gingivo-buccal sulcus (also known as Indian cancer) behaves differently from carcinoma of the tongue. Oral cancer is very often diagnosed at an advanced stage with neck metastasis, and most cases have a guarded prognosis. Loco-regional recurrences are frequent and morbidity following treatment is considerable. However, results have improved in recent years, particularly in early and certain advanced stages, due to better imaging and case selection, improved surgical techniques, including those for reconstructive surgery, a multidisciplinary team approach and a better understanding of tumor biology and prognostic factors. This book comprehensively and systematically reviews all these aspects of diagnostic and therapeutic advances in oral cancer, particularly discussing early detection, epidemiology, chemoprevention and current research. Written by specialists who are active leaders in basic sciences or clinical fields, the chapters address individual and collective issues in managing patients with oral cancer, and provide insights into various treatment approaches. The authors share their knowledge and experience and provide extensive literature sources to encourage clinicians to be flexible, innovative and help them make the best, educated decisions for individual patients.

This excellently illustrated book provides a thorough overview of the management of orbito-zygomaticomaxillary fractures, which can be complex since both function and facial form may be affected. Practical guidance is offered on all aspects, including clinical examination, CT assessment, surgical planning, surgical access and techniques, soft tissue management, intra- and postoperative assessment, and management of complications. In addition, important technological advancements in planning and treatment are described, including the use of navigation systems and 3D printing. Finally, the authors discuss strategies involving delayed surgical intervention and revision surgery for the malpositioned zygomatic maxillary complex. Management of Orbito-zygomaticomaxillary Fractures will be of value for oral and maxillofacial/craniomaxillofacial surgeons at all levels of experience.

"Orthopaedic infections represent common, potentially devastating, and sometimes fatal complications that can occur after any surgery. Infections associated with orthopaedic trauma are especially prevalent, and there is an increasing incidence of bone infections linked to a greater number of joint arthroplasties being performed annually. Management of Orthopaedic Infections: A Practical Guide by renowned orthopaedic surgeon and researcher Antonia Chen is a practical clinical reference to assist clinicians in the diagnosis and treatment of challenging infections spanning the entire orthopaedic specialty"-- Provided by publisher.

This comprehensive book presents the latest evidence-based data on pancreatobiliary malignancies, including the epidemiology, examination, treatment and endoscopic management. It explores a range of topics, such as risk factors, detection strategies, and novel treatment approaches like precision medicine and immunotherapy. Although there have been rapid improvements in the management of these diseases, the survival period has not yet reached a satisfactory level. This book will help those doctors needing to share the latest information with the patients and their families. It provides a wealth of practical information to help surgeons, endoscopists and oncologists as well as physicians, basic researchers and professionals at medical device and pharmaceutical companies broaden their understanding of the current treatment and management strategies for pancreatobiliary malignancies.

This book provides the reader with a multidisciplinary approach that is state of the art and reflects input from the European Neuroendocrine Tumor Society and the North American Neuroendocrine Tumor Society. In particular, the text focuses on the pathophysiology of neuroendocrine tumors and includes a comprehensive review of the most recent developments in understanding the complex hormone and receptor signaling that is important for the future development of potent pharmacological treatments. The volume reviews the pathological grading and staging systems providing useful clinical information for the treating clinician as well as a useful reference for pathologists. The clinical management of neuroendocrine tumors is reviewed enabling the treating physician to understand the diagnostic approaches to differentiating the various types of neuroendocrine tumors. In addition, the treatments are reviewed in great detail and include novel radiological, surgical, and chemotherapeutic approaches. The reader will utilize this book as both a comprehensive and quick reference guide through the use of diagnostic and treatment algorithms. Written by international experts in their particular field of study, Management of Pancreatic Neuroendocrine Tumors will be of great value to medical oncologists, endocrinologists, gastroenterologists, pathologists, surgeons, and diagnostic and interventional radiologists.

This book provides an overall introduction to the medical management of dementia with chapters dedicated to specific topics such as pain, epilepsy, vascular risk factors in dementia and review of medication, which are often not addressed in books on the subject, and thereby filling a gap in the field. Chapters are supplemented with cases to highlight key concepts and treatment approaches, and to provide the reader with the possibility to reflect on management options and the readers own current practice. This book is aimed at clinicians of different specialties (mainly neurology, psychiatry, geriatric medicine and general practice/family medicine) who manage patients with dementia on a regular basis, and thus provides useful guidance to be used in the clinic.

Comprised of illustrative clinical cases, this unique pocket guide presents descriptions of patients who have symptoms, physical signs or laboratory abnormalities that they believe are due to disorders of the endocrine system (hormone secreting glands and overall metabolism) but which are not, or probably are not, due to an endocrine disorder. These are common situations in the clinical practice of endocrinology. Each chapter includes clinical cases illustrating differing presentations and outcomes, and each individual case description is followed by a discussion that includes the differential diagnosis of these symptoms, signs and/or lab abnormalities and why they are not likely due to endocrine disease or, alternatively, why and how a deeper exploration for endocrine disorders might be needed. In all cases, an emphasis is placed on listening to the patient and providing a respectful and compassionate response and approach to evaluation and management of the proposed disorder. Discussions are referenced whenever reference material is available, and evidence-based clinical practice guidelines are presented whenever applicable. Topics discussed include chronic and adrenal fatigue, obesity, anxiety and depression, sweating and flushing, alcohol- and opioid-induced symptoms, low testosterone, pseudo-hypoglycemia and pseudo-Cushing's syndrome, among others. Clinical endocrinologists, primary care physicians and related allied medical professionals will find Management of Patients with Pseudo-Endocrine Disorders a valuable resource in their clinical practice with these common but often challenging patients.

This book provides a comprehensive and up-to-date overview of the surgical treatment of pelvic organ prolapse, focusing especially on issues that continue to arouse controversy. In the first section, leading experts present detailed information on the surgical anatomy, pathophysiology, and epidemiology of prolapse and also the impact of concomitant functional disorders. The second section focuses on diagnostic work-up and the third is dedicated to the various treatment options aimed at resolution of the condition. The closing chapters discuss outcome measures and analyze the effects of prolapse surgery on urinary, bowel, and sexual symptoms. In 1966 Richard TeLinde stated that, "Every honest surgeon of extensive and long experience will have to admit that he is not entirely and absolutely satisfied with his long-term results of all his operations for prolapse and allied conditions." Although many uncertainties in the field have since been resolved, some major issues still require clarification. Often it can be difficult to find the right balance between treatment effectiveness in the long term and risk reduction, including with respect to complications. This book will help trainees and less experienced surgeons to make appropriate treatment choices and achieve optimal outcomes.

Management of Penile Cancer provides a comprehensive and state-of-the-art overview of the major issues specific to the field of penile cancer. The sections of the book are structured to review the overall scope of issues of penile cancer, including diagnosis and staging, surgical approaches, and the treatment of advanced disease. As multidisciplinary care is an integral part of the treatment of penile cancer, this book is unique in the inclusion of collaborating authors from a variety of integrated disciplines, including urology, radiation oncology, medical oncology, and reconstructive surgery. Written by recognized experts in their field, Management of Penile Cancer is a unique and valuable resource in the field of penile cancer, both for those currently in training and for those already in clinical or research practice.

The clinical aspects of pericardial disease encompass acute and recurrent pericarditis, pericardial effusion and pericardial tamponade, constrictive pericarditis, and effusive-constrictive pericarditis. These disorders differ not only in clinical presentation but also in the timeline of development, thus management of pericardial disease can be challenging for many clinicians. To assist medical professionals with this often complex area, this book provides an extensive review of pericardial disease evaluation and management in a unified, stepwise pathway-based approach. Management of Pericardial Disease contains a selection of defining clinical images to guide in identification and management of pericardial disease. Fellows, residents, cardiologists, thoracic medicine physicians, cardiothoracic surgeons, radiologists, and intensive care and emergency medicine physicians alike will find this book to be an essential resource for developing the skills and knowledge applicable to managing pericardial disease in patients.

This book illustrates the currently available strategies for managing phytonematodes. It discusses the latest findings on plant-pathogen-microbiome interactions and their impacts on ecosystems, and provides extensive information on the application of microorganisms in the sustainable management of phytonematodes. This is followed by an in-depth discussion of the application of potential strains of biocontrol fungi, endophytes and actinomycetes to enhance plants ability to fend off phytonematode attacks, leading to improved plant health. In conclusion, the book addresses new aspects like the biofabrication of nanoparticles and their application in plant disease management, and presents an extensive list for further reading.

This book highlights the underlying importance of post-stroke complications during recovery, allowing healthcare professionals managing stroke patients to understand their frequency and identify which patients are at risk of developing such complications. Complications are categorised into neurological and non-neurological, and the time-frame for these complications both in the short-term and long-term are discussed. The common practices in managing post-stroke complications and the skills required in their prevention are described, as is the evidence base from clinical trials around their management. The book concludes with a discussion of new developments and research priorities for the future. Management of Post-Stroke Complications is aimed at members of the multidisciplinary stroke team, stroke physicians, neurologists, general practitioners, stroke specialists in training, and medical students.

Now in a fully revised and updated fourth edition, this book remains the most comprehensive resource on Prader-Willi syndrome (PWS) available on the market. There have been significant changes in the diagnosis, clinical care and treatment of PWS since the previous edition was published in 2006, and more thorough information on understanding the cause and diagnosis of the condition, along with clinical presentation and findings with natural history data now available. The book is divided into three thematic sections. Part One discusses the genetics, diagnosis, research and overview of PWS, including current laboratory testing. The medical physiology and treatment of PWS comprise Part Two, covering the GI system, obesity as well as the use of growth hormone. Part Three, the largest section, presents a wide-ranging, multidisciplinary management approach to PWS, attending to the many manifestations of the condition. Topics here include neurodevelopmental aspects, speech and language disorders, motor issues, psychological and behavioral management, educational and transitional considerations, vocational training and residential care, and advocacy for both school discipline and sexuality. Syndrome-specific growth charts, benefits eligibility information and additional resources are included in helpful appendices. Timely and well-crafted, this latest edition of Management of Prader-Willi Syndrome remains the gold standard for clinicians and health care providers working with patients diagnosed with this rare obesity-related genetic disorder.

Epidemiology and risk factors / Ranko Miocinovic -- Twenty years and counting : is PSA still useful in 2010? / Haluk Ozen and Sertac Yazici -- Prostate cancer screening : a review of the evidence with clinical practice implications / Timothy J. Wilt -- Beyond PSA : promising new markers for prostate cancer / Leonard Marks -- Hereditary prostate cancer and genetic risk / Adam C. Reese, Graham Casey, and John S. Witte -- Prostate inflammation and prostate cancer / William G. Nelson ... [et al.] -- Molecular progression of prostate cancer : androgens and estrogens / Stephen A. Boorjian and Donald J. Tindall -- The role of obesity and diet in prostate cancer / Jean-Alfred Thomas II and Stephen J. Freedland -- Prostate cancer risk reduction by chemoprevention / Kenneth G. Nepple, Adam S. Kibel, and Gerald L. Andriole -- Current issues in pathologic evaluation / Sara M. Falzarano, Howard S. Levin, and Cristina Magi-Galluzzi -- Optimum prostate biopsy : techniques and strategies / Osama M. Zaytoun and J. Stephen Jones -- The utility of nomograms in routine clinical practice / Carvell T. Nguyen and Michael W. Kattan -- Active surveillance comes of age / Laurence Klotz -- Focal therapy : prostate hemiablation as the first historical treatment model for focal therapy of early stage prostate cancer / Vladimir Mouraviev and Thomas J. Polascik -- Contemporary external beam radiotherapy / Rahul Tendulkar and Kevin Stephans -- Surgery, brachytherapy, or external beam radiation for low- and intermediate-risk disease? / Jay P. Ciezki and Eric A. Klein -- The role for radical prostatectomy in advanced prostate cancer / R. Jeffrey Karnes and Michael L. Blute -- Radiation therapy in the management of locally advanced prostate cancer / Joseph D. Mancias and Anthony L. Zietman -- Clinical implications of measuring quality-of-life in early stage prostate cancer / Peter Chang, Mehrdad Alemozaffar, and Martin G. Sanda -- Treatment modalities of post-prostatectomy incontinence : a historical perspective as well as current therapy options / Christina Ching and Drogo K. Montague -- Management of biochemical recurrence after localized treatment for prostate cancer / Stephen B. Williams and Toni K. Choueiri -- Management of newly diagnosed metastatic disease / C. Lance Cowey and Thomas E. Hutson -- Pitfalls of androgen deprivation therapy / Alicia K. Morgans and Matthew R. Smith -- Current management of castration-resistant prostate cancer (CRPC) / Jorge A. Garcia and Robert Dreicer -- Beta-emitting radiopharmaceuticals and bone metastasis / Oliver Sartor.

This exhaustive review of prostate cancer management covers epidemiology, biology, chemoprevention, screening and diagnosis, therapies including surgery, radiation, high-intensity ultrasound, cryotherapy, and more. Includes up-to-date clinical trial data.

The Management of Scientific Integrity within Academic Medical Centers discusses the impact scientific misconduct has in eight complex case studies. Authors look at multifaceted mixtures of improper behavior, poor communication, cultural issues, adverse medical/health issues, interpersonal problems and misunderstandings to illustrate the challenge of identifying and managing what went wrong and how current policies have led to the establishment of quasi legal processes within academic institutions. The book reviews the current global regulations and concludes with a section authored by a US federal court judge who provides his perspective on the adequacy of current regulations and policies.

This book provides sound clinical guidance on the treatment of adults and children with severe head injuries, from the time of initial contact through to the rehabilitation center. Offers recommended diagnostic and therapeutic measures, and useful flow charts.

"Recent breakthroughs in the diagnosis and treatment of smell and taste disorders have dramatically altered clinical outcomes for these patients. In this important book, readers will get a full overview of the topic today, including functional anatomy, pathophysiology, diagnostic and clinical work-up, assessment techniques, medical and surgical options, and more. Focused and to-the-point, the book is especially designed for physicians treating patients in the everyday practice setting. Special Features: Written by the fields foremost leaders, who chair international working committees and run annual courses on olfaction and gustation, Covers the most important advances in diagnostic and treatment techniques, Provides a clear methodology for examining, testing, classifying, diagnosing, and treating a wide range of idiopathic, congenital, and acquired smell and taste disorders, Explores the use of MRI for improved visualization of central olfactory areas, including the lesions and other disturbances that cause olfactory disorders, Offers new information on the interaction between the chemical senses, especially important in medicolegal cases, Includes more than 130 full-color diagrams, clinical pathways, tables, photographs, and anatomic illustrations that clarify all concepts. Complete with expert foundational chapters on the anatomy and structure of the olfactory and gustatory systems, as well as compelling information on quality-of-life issues, this book makes a major contribution to the field. It is essential for otolaryngologists, neurologists, internists, residents, and other specialists treating patients with smell and taste disorders in a modern clinical setting"--Provided by publisher.

There are many books describing in detail the evaluation, diagnosis and management of OSA, but this is a first practical guide which comprehensively describes this condition. The incidence of snoring and obstructive sleep apnea is on rise and this practical guide will help not just specialists but also residents and fellows in treating their patients with Obstructive sleep apnea. Essential information is summarized in the form of charts and surgical steps are summarized in the form of diagrammatic illustration making it easy for the learners. This book additionally would help the medical practitioners to get a practical insight in the management of patients. This book will describe each entity of sleep disordered breathing, evidence based protocols , diagnostic tools required for identifying , medical therapies that will help in appropriate patients, Devices that can be used for its management . This book will also describe on how to select patients for surgery and how tailor the surgery as per the anatomy of the patient.

Management of Soft Tissue Sarcoma addresses the diagnosis and best current management of adult soft tissue sarcomas. Edited by world renonwed experts, this book dileneates and discusses each different sarcoma subtype individually -- source other than Library of Congress.

PART I. Introduction -- 1. General description -- 2. Natural history: importance of size, site, histopathology -- 3. General statement as to efficacy of surgery, chemotherapy, radiation therapy and immunotherapy -- PART II. Management By Histopathology -- 4. Gastrointestinal stromal tumors -- 5. Liposarcoma -- 6. Leiomyosarcoma -- 7. Undifferentiated pleomorphic sarcoma (UPS) (malignant fibrous histiocytoma (MFH) and myxofibrosarcoma) -- 8. Synovial sarcoma -- 9. Malignant peripheral nerve sheath tumor (MPNST) and triton tumor -- 10. Desmoid tumor/deep-seated fibromatosis (desmoid-type fibromatosis) -- 11. Soitary fibrous tumor/hemangiopericytoma -- 12. Fibrosarcoma and its variants -- 13. Vascular sarcomas -- 14. Epithelioid sarcoma -- 15. Sarcomas more common in children -- 16. Radiation-induced sarcoma -- 17. Alveolar soft part sarcoma -- 18. Clear cell sarcoma/melanoma of soft parts -- 19. Desmoplastic small round cell tumor -- 20. Extraskeletal myxoid chondrosarcoma -- 21. Other uterine sarcomas -- 22. Extraskeletal osteogenic sarcoma -- 23. Sustentacular tumors of lymph tissue -- 24. Uncommon/unique sites -- PART III. Benign And Less Aggressive Lesions -- 25. Mostly benign/rarely metastasizing -- 26. Selected benign tumors -- 27. Reactive lesions -- Index.

This book focuses on subarachnoid hemorrhage (SAH), describing in detail the neurophysiology, anatomy, epidemiology, grading, anesthesia management, coiling and interventional treatment of this dangerous disease. Written by leading international experts, it highlights the state-of-the-art techniques for the diagnosis and treatment (non-surgical and surgical) of SAH and the clinical variations. It also examines the reliability of the new techniques versus the standard clinical methods to predict problems related to SAH and its recent diagnosis and management. The book starts with a brief discussion of the epidemiology of SAH, cerebral circulation, anatomy of brain blood vessels and neurophysiology related to this fatal disease. Then, in the following chapters it covers grading of subarachnoid hemorrhage, anesthesia management of SAH, treatment, subarachnoid hemorrhage coiling and radiological intervention. Lastly, it explores surgical treatment of intracranial aneurysms in more detail, and addresses complications, critical care management and headache in SAH, traumatic SAH and prognosis. Featuring numerous images, tables, schema, illustrations and videos, the book is intended for junior and senior anesthesiologists, neuroscientists, intervention radiologists, intensivists and neurosurgeons.

Over the last several decades breast cancer management has made great strides in the improvement of oncologic treatment outcomes, particularly so in patients with early stage disease. While wide-spread access to screening resulting in early detection is undoubtedly to be credited for this trend, at the same time, the management of breast cancer has evolved to be an intricate multidisciplinary collaboration between breast imagers, surgeons, medical oncologists and radiation oncologist. As a result, with better mutual understanding of multidisplinary goals and challenges, the treatment strategies have become more individualized, with a great emphasis being placed on the intrinsic disease biology. Furthermore, the indications for neoadjuvant systemic therapy have significantly broadened, with a substantial number of patients with early stage breast cancer being able to take advantage of this strategy to decrease the extent of breast surgery they would undergo at its completion. As such, the management of the axilla in these patients has presented with new challenges as well as with new opportunities to scale down on the extent of local therapy and, consequently, its toxicity. This text will provide a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians (surgeons, medical oncologists, radiation oncologists) and researchers with an interest in breast cancer. The book will review novel and evoling strategies in neoadjuvant systemic therapy forn early stage breast cancer, provide new perspectives about appropriate axillary imaging in anticipation of neoadjuvant systemic therapy, and describe new data on innovative surgical techniques and Radiation Oncology concepts designed to deescalate the extent and toxicity of local therapy while insuring oncologic safety. Several landmark clinical trials have been published in the last few years and will be placed in context with respect to current management. Integration of novel diagnostic and interventional breast imaging, local therapy (surgery and radiation) with contemporary systemic therapy will also be discussed. This text will serve as a very useful resource for physicians and researchers dealing with, and interested in, this challenging field. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters will be written by experts in their fields and will include the most up to date scientific and clinical information.

Complications during airway management occur frequently when treating children. Although tracheal intubation is a routine procedure, there are no pediatric texts dedicated to this essential practice. The lack of specific resources and knowledge makes treating children with complex airways even more challenging. This landmark book is dedicated to the successful management of the complex pediatric airway. It explores and evaluates current research and covers novel topics such as airway ultrasonography and apneic oxygenation. It delineates the risks associated with intubating children, and their preventative measures. Aimed at clinicians involved in airway management in any form, this book covers the basics of airway management and how to perform a variety of essential techniques. Both occasional and exclusive pediatric clinicians will find this a valuable resource to support best practice. The book is supplemented by additional videos online, enhancing the demonstration of devices and techniques discussed in the text.

Management of the Patient at High Risk for Breast Cancer provides a state-of-the art review of patients who are at high risk for breast cancer, how to identify them, the tools available for risk assessment and quantification and indications for genetic counseling and testing. The book summarizes the high risk breast imaging options, including newest techniques and schedules. Pathologic evaluation of high risk lesions are featured as well as the management issues surrounding these lesions. The volume also covers the management of concomitant cancer risk and screening strategies.

Molecular risk stratification of well-differentiated thyroid cancer -- The significance of cervical lymph nodes in well-differentiated thyroid cancer -- Management of the central compartment in well-differentiated thyroid carcinoma -- Management of the lateral neck in well-differentiated thyroid cancer -- The management of recurrent/persistent well-differentiated thyroid cancer in the central compartment -- Management of distant metastases in differentiated thyroid cancer -- Risk-adjusted strategies in post-treatment surveillance of well-differentiated thyroid carcinoma -- Medullary thyroid cancer -- Anaplastic thyroid cancer: Current concepts -- External beam radiotherapy for thyroid cancer -- Targeted therapies in thyroid cancer.

Incidence and Epidemiology -- The Clinically Detected and Palpable Thyroid Nodule -- Ultrasound of the Thyroid and Soft Tissues of the Neck -- Thyroid Nodule Biopsy -- The Bethesda System of Reporting Cytopathology (BSRTC) -- Utility of Non-Ultrasound Imaging for the Evaluation of Thyroid Nodules and Cancer -- Surveillance of Benign Thyroid Nodules -- Role of Medical Management -- Role of Surgery -- Surgical Intervention for Indeterminate Nodules -- Staging -- Importance of Surgeon Experience in the Surgical Management of Thyroid Cancer -- The pediatric thyroid nodule and Papillary Thyroid Cancer Management -- Microcarcinoma -- Surgical Management of Low Risk Papillary Thyroid Cancer -- Management of the Central Neck Lymph Nodes: Prophylactic Central Lymph Node Dissection vs. Therapeutic -- Management of the Persistent and Recurrent PTC Lymph Node Metastases -- Management of Thyroid Nodules and Cancer in the Pregnant Patient -- Perioperative Management of the Voice and Calcium -- Initial Treatment/Ablation Based on Risk Stratification -- Treatment of Recurrent/Metastatic Thyroid Cancer with RAI -- Surveillance of Treated Thyroid Cancer Patients and Thyroid Hormone Replacement and Suppression -- Holistic and Integrative Approaches to Patients Undergoing Thyroid Surgery -- Follicular and Hurthle Cell Carcinoma -- Locally Advanced Differentiated Thyroid Cancer: What Are the Surgical Treatment Options? -- External Beam Radiation for Locally Advanced and Metastatic Differentiated Thyroid Cancer -- Systemic Therapy for Advanced Metastatic Thyroid Cancer.

This volume offers a comprehensive guide to the prevention, management of injury, risk factor mitigation, and rehabilitation in track and field athletes. It serves as a valuable resource for the sports medicine community, including surgeons, sports medicine physicians, physical therapists, and athletic trainers. In addition to addressing current management techniques for injuries, the book discusses various special considerations, e.g. biologics, the aging athlete, rehabilitation, nutrition, and gender. Published in collaboration with ISAKOS, this book offers an updated information authored by experts in the field, and a valuable contribution to the field of orthopedics and sports medicine.

Managing urologic cancer by preserving, as opposed to removing, affected tissue, is rapidly becoming the favoured choice for urologists and oncologists. Discover all available options and how to achieve the best possible patient management with this expert guide to the area. The editor, Mark Schoenberg, is an internationally-renown expert in this exciting new area and has recruited an outstanding team featuring some of the leading urologists/oncologists in North America and Europe to assist him.

The risk of cancer increases with age and the number of older adults seeking treatment is rising dramatically in line with the aging population. The care of older patients differs from that of younger adults because of variation in the biology of the tumor, age-related variation in host physiology, co-morbidity burden and psychosocial issues, which might impact the efficacy and side effects of cancer therapy.Management of Urological Cancers in Older People focuses on treatment strategies of urological cancers and provides guidance on the issues specific to older patients, spanning background and epidemiology, special considerations in the care of older people, therapeutics, and psychosocial considerations. This book offers a thorough review of current approaches to treating older urological cancer patients, detailing the special issues and considerations involved. The discipline-spanning coverage outlines best practice and proposes topics for future research.This first volume in the Management of Cancer in Older People series will be of interest to all surgical oncologists, medical oncologists, gerontologists, urologists and other members of the multidisciplinary team involved in the care of elderly urological cancer patients.

This book provides a comprehensive overview of contemporary evidence-based management of urothelial carcinoma. The first part of the book is devoted to urothelial carcinoma of the bladder and includes detailed description of the diagnosis and treatment of non-muscle-invasive, muscle-invasive, and advanced or metastatic disease. Attention then turns to upper tract urothelial carcinoma (UTUC), with individual chapters on diagnosis, nephron-sparing surgery, nephroureterectomy, and treatment of advanced or metastatic UTUC. The text is supported by many illustrations, photos, and tables that clarify management, and surgical video clips are also available to readers. The book will be a welcome addition to the literature as progress continues to be made in understanding the exact pathophysiology of urothelial carcinoma and in developing more effective diagnostic and therapeutic modalities. It will be useful both to researchers in the field of urothelial carcinoma and to clinicians, including especially residents and fellows.

Intro; Preface; Contents; Contributors; Chapter 1: Introduction to Copper Metabolism and Wilson Disease; Introduction; Cellular Mechanisms of Copper Transport; Wilson Disease; Abnormal Copper Metabolism and Injury in Wilson Disease; Ceruloplasmin: A Marker of Wilson Disease and Copper Status; When Copper Is in Excess; Summary and Conclusion; References; Chapter 2: Diagnosis Confirmation and Screening of Wilson Disease; Introduction; Patients to Test for Wilson Disease; Liver Disease and Extrahepatic Involvement in Wilson Disease The Neuropsychiatric Manifestations of Wilson Disease: More than Meets the EyeTremor; The Cranial Nerves; The Cerebellum; Psychiatric Symptoms; Other Organs Involved in Wilson Disease; Confirming the Diagnosis; Slit-Lamp Examination for Kayser-Fleischer (KF) Rings; Serum Ceruloplasmin; Free (Unbound) Serum Copper; Twenty-Four-Hour Urinary Copper; Genetic Analysis: Testing for ATP7B Mutations; Liver Biopsy: Histology and Hepatic Copper Concentration; Hemolysis (Breakdown of Red Blood Cells); Imaging Tests; Acute Liver Failure Secondary to Wilson Disease; Family Screening; Conclusion Dietary Modifications in Wilson DiseaseFood; Water; Cooking Methods; Nutritional Supplements; Special Considerations; Liver Disease; Neurological Involvement; Dysphagia; Nutrition Support; Resources; One-on-One RD Assistance; USDA Food/Nutrient Database; Conclusion; References; Chapter 5: Treating Other Symptoms of Wilson Disease: The Liver; Introduction; Asymptomatic or Mild Symptoms; Portal Hypertension; Varices (Esophageal and Gastric); Management of Variceal Bleed; Ascites; Treatment of Resistant Ascites; Spontaneous Bacterial Peritonitis; Sepsis; Hepatic Encephalopathy; Malignancy Acute Liver FailureBibliography; Chapter 6: Treatment of Neurological Symptoms in Wilson Disease; Introduction; Neurological Manifestations of WD; Tremor; Medications for Action Tremor; Dystonia; Treatment Options for Dystonia; Botulinum Toxin Injections; Oral Medications; Parkinsonism; Cerebellar Ataxia; Dysphagia; Neurological Manifestations in Children; Clinical Scales Used for Neurological Evaluation of WD; Neuroimaging in WD; Conclusion; Bibliography; Chapter 7: Psychiatric Aspects of Wilson Disease; Introduction; Evaluation of Psychiatric Symptoms in WD

This book is aimed at illustrating the common complicated ocular trauma with typical signs, examinations, surgical procedures and conservative management to clinical practitioners including the nurses, medical students, residents, fellows and ophthalmologists, and help them make the most appropriate decision on the diagnosis and management of such patients. There are 23 chapters introduced in the book, which covers all types of complicated ocular trauma with brief case reports combined with the most comprehensive pictures. For each disease, a brief introduction, explanation as well as management are offered to the readers. With the illustrative figures and explanations, the goal of making the right diagnose, offering the best advice or treatment to the patients, and understanding surgical procedures would be easily achieved. This book is useful for readers to be fully prepared for the challenge of complicated ocular traumatic cases. This is the fifth volume of the book series Ocular Trauma.

This quick-reference guide is designed for those who work with young children in child care and school settings. Topics cover social-emotional development, biting, napping difficulties, PTSD, gender development, self-stimulation behaviors, and more. In addition to behavioral issues commonly seen in small children, the editors touch on epigenetics, medications, toxic stress, ACEs (adverse childhood experiences), and how to help children who have undergone traumatic experiences

Featuring numerous case studies and state-of-the-art marketing models, this thorough resource provides a comprehensive overview of the new business context and marketing models for biotech companies. -- Edited summary from book.

"Managing Bipolar Disorder in Clinical Practice", Third Edition, is an up-to-date, concise practical handbook developed with the clinician in mind. Including the most recent clinical guidelines, including the British Association for Psychopharmacology (BAP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines, this handbook is intended to highlight every major aspect of this serious mental health disorder, including assessment, treatment, long-term management, and recent developments.

Obesity has become a worldwide epidemic. An increasing number of patients are undergoing weight loss procedures, resulting in an increase in patients with massive weight loss desiring body contouring surgeries. These patients can present with very challenging deformities of skin laxity, and are at higher risk of complications. Most texts only provide a chapter with basic descriptions of procedures for managing moderate deformities, with short discussions of complications. Managing Body Contouring Challenges and Complications offers comprehensive insight on the management of the most complex deformities after weight loss. Procedures are described in a step-by-step fashion, including small pearls of knowledge. This book also includes complex subjects not addressed in other books such as arm band deformities in brachioplasty, gluteal crease elongation in lower body lifting, recurrent saddlebag deformities, breast implant problems in massive weight loss, and many other topics. Managing Body Contouring Challenges and Complications focuses on the most challenging deformities and how to optimize results. Disappointing long term results are used to teach key areas of difficulty or potential pitfalls to avoid. This book also highlights evidence-based outcomes data from large studies to help guide surgical decision making.

Breathlessness Management in Clinical Practice presents evidence-based practical techniques for helping the breathless patient with advanced disease of any aetiology used in the Cambridge Breathlessness Intervention Service (CBIS). This book will help individuals in the multidisciplinary team both manage breathlessness in their current clinical setting and describe the breathlessness service model which can be adapted for use in any situation. It uses a model of care based on interventions for breathing, thinking and functioning. Breathlessness Management in Clinical Practice is an invaluable resource for those working in the respiratory medicine, oncology and cardiology and other specialties where breathlessness is commonly managed although less recognised like nephrology and neurology. It will be of help to occupational therapists, physiotherapists and specialist nurses as well as physicians. It will also be of interest to anyone who wishes to increase their knowledge of the advances in evidence that now enable clinicians to offer much improved care for those suffering with frightening symptom of breathlessness.

Managing Cancer Breakthrough Pain is a comprehensive review of cancer breakthrough pain (cBTP) and rapid-onset opioids (ROO), the only treatment approved for cBTP episodes. The book was originally commissioned due to the current rapid growth of the ROO market and the epidemic of ROO abuse. This book will review the historical background and definitions of cBTP and ROOs, assessment methods to determine types of cBTP, US- and EU-approved ROOs, case studies (which will provide practical applications of ROO treatment options), ROO abuse and screening methods, and the FDA-mandated TIRF REMS Access program (Transmucosal Immediate Release Fentanyl Risk Evaluation and Mitigation Strategies Access program). Busy healthcare professionals who have a basic understanding of cancer pain but want to learn more about cBTP and ROOs will benefit from this concise guide that will help them quickly understand the complexities of cBTP episodes and ROOs.

Overview -- 1.Epidemiology of cancer in pregnancy -- 2.Staging workup in pregnant cancer patients -- 3.General concepts on surgical management of cancer during pregnancy -- 4.Role and consequences of radiotherapy in managing cancer during pregnancy -- 5.Pharmacokinetics of systemic anti-cancer therapies during pregnancy -- 6.Obstetrical care of a pregnant woman with cancer -- 7.Psychological and psychosocial care of a pregnant woman with cancer -- 8.Supportive care during pregnancy -- 10.Neonatal care and long-term consequences of in-utero exposure to systemic anticancer therapy -- Disease-specific chapters -- 11.Managing breast cancer during pregnancy -- 12.Managing melanoma during pregnancy -- 13.Managing cervical cancer during pregnancy -- 14.Managing ovarian tumors during pregnancy -- 14.Managing lymphoma during pregnancy -- 15.Managing leukemia during pregnancy -- 16.Managing thoracic cancers during pregnancy.

The vascular endothelium in diabetes / Andrew Lansdown, Elizabeth Ellins, Julian Halcox -- New biomarkers of cardiovascular disease in diabetes / Hitesh Patel, Sujay Chandran, Kausik K. Ray -- Kidney disease in diabetes / Amanda Y. Wang, Meg Jardine, and Vlado Perkovic -- Vascular imaging / Kiyoko Uno, Jordan Andrews and Stephen J. Nicholls -- Glycaemia and CVD and its management / Jeffrey W. Stephens, Akhila Mallipedhi, Stephen C. Bain -- Hypertension and cardiovascular disease and its management / Jose A. García-Donaire and Luis M. Ruilope -- Dyslipidaemia and its management in type 2 diabetes / D. John Betteridge -- Thrombosis in diabetes and its clinical management / R.A. Ajjan and Peter J. Grant -- Diet and lifestyle in CVD prevention and treatment / Alice H. Lichtenstein -- Management of acute coronary syndrome / Christopher M. Huff and A. Michael Lincoff -- Management of peripheral arterial disease / Rüdiger-Egbert Schernthaner, Gerit-Holger Schernthaner, Guntram Schernthaner.

"This fully revised and updated resource helps teachers and caregivers address the challenges of caring for children with chronic health conditions and special health care needs in child care and school settings"--Publisher's description.

Chronic pain has a multitude of causes, many of which are not well understood or effectively treated by medical therapies. Individuals with chronic pain often report that pain interferes with their ability to engage in occupational, social, or recreational activities. Sufferers' inability to engage in these everyday activities may contribute to increased isolation, negative mood and physical deconditioning, which in turn can contribute to their experience of pain. Cognitive-behavioral therapy (CBT) has been proven effective at managing various chronic pain conditions, including rheumatoid arth.

Offering the perspective of seasoned surgeons who have seen, thought about, and worked through the common and uncommon problems that can arise in aesthetic breast surgery, this book serves as a reference to guide surgeons through the steps of understanding, potentially avoiding, and then treating these issues. Managing Common and Uncommon Complications of Aesthetic Breast Surgery is methodical in its approach, beginning with key relevant highlight of embryology and anatomy of the breast and continuing into common problems in breast surgery, implant-related surgery, breast lifts and reductions. A variety of pitfalls are also explored from rupture, capsular contracture, and implant malposition to the rare and uncommon surface-texture related lymphoma. Every process is explored in depth with carefully crafted, practical, and experientially tested solutions proposed. Featuring real patient photos, detailed tables, and high definition videos for supplemental learning, this text is a one-stop reference to help surgeons understand, manage, and treat complications in aesthetic breast surgery both common and uncommon.

Managing Common Interventional Radiology Complications: A Case Based Approach is an easy-to-use manual that will help trainees and practising radiologists by providing cases which cover most of the complications that a general interventionalist may encounter in normal practice. The cases are presented succinctly but thoroughly, so that the reader is equipped to manage the complication immediately. Managing Common Interventional Radiology Complications: A Case Based Approach aims to teach the range of procedures involved in interventional radiology, and focuses on the complications that can arise in the process.

This well-illustrated book is intended as the go-to guide for the identification and management of the complications associated with specific glaucoma procedures. All of the routinely performed procedures are covered: filtration surgery, including trabeculectomy and ExPRESS shunt, nonpenetrating surgeries such as deep sclerectomy and canaloplasty, procedures involving the placement of tube shunt devices, glaucoma laser treatments, and minimally invasive glaucoma surgeries (MIGS). The book is succinct but sufficiently detailed to provide the reader with a very well informed description of possible complications and the best way to manage them, based on the evidence from recent and seminal research. The authors are recognized experts who come from a wide geographic and varied glaucoma background. The book will be ideal for all surgeons, whether new or experienced, who seek easily accessible, reliable guidance on how to manage the intraoperative and early and late postoperative complications that may arise when performing glaucoma surgery.

Concepts and strategy -- Airway related problems -- Vascular access -- Regional anaesthesia -- Medication related problems -- Pre-existing conditions.

The book includes recommendations for COPD from published guidelines (eg, the GOLD, ATS, and NICE guidelines) and presents them in the context of relevant clinical treatment issues. This is an in-depth guide on the management of COPD, concentrating on the impact of COPD on a patient as well as how healthcare professionals can intervene and educate the patient at an early stage and thereby slow the onset of severe symptoms.

This book covers the complexity of diabetes and related complications and presents the socio-economic burden of the disease, taking into account the rising prevalence reaching pandemic proportions and the associated costs. Factors causing high diabetes prevalence and the influence of the pharmaceutical industry are evaluated and solutions for sustainable diabetes care with limited resources are provided, including national focus on providing cost-effective diabetes treatment, nutrition and physical activity, structured diabetes education and centralized National e-Health System. Moreover, elaboration of long-term efforts to curb the diabetes burden through prevention activities are presented in this book. Managing Diabetes in Low Income Countries represents an essential guide for diabetes care clinicians and researchers, medical students and clinicians in training, diabetes policy makers, regulatory authorities, international diabetes and patient organisations all of whom are involved in current clinical practice for diabetes management.

This handbook is an overview of the diagnosis, treatment and long-term management of diabetic retinopathy, within the context of overall long-term diabetes disease management. Diabetes-related eye damage (diabetic retinopathy) is one of the most common complications of diabetes, affecting approximately 30-40% of people with diabetes. The situation is so severe that in countries such as the US and UK, diabetic retinopathy is currently the leading cause of blindness in people age 20 to 74 years old. Fortunately, there are several existing and emerging treatments on the horizon and with adequate control of the underlying diabetes, this condition can be successfully managed.

An overview of the diagnosis, treatment, and long-term management of diabetic-related kidney disease in clinical practice. Includes an evidence-based discussion of currently available and experimental drug therapies currently in development, guided by international consensus guidelines. Ideal for physicians, medical trainees, nurses and other medical professional that regularly screen and treat patients with all types of diabetes.

This text is designed to present a comprehensive and state-of the-art approach to dismounted complex blast injuries. Sections address care of these patients from the point of injury through rehabilitation. The specific areas addressed include blast mechanics, stabilization and hemorrhage control at the point of injury, early resuscitation at local hospitals, a systematic approach to surgical care, and finally reconstruction and rehabilitation. Specific chapters focus on operative management of pelvic, abdominal, genitourinary, orthopedic, neurological and thoracic injuries. The authors of each chapter, are experts in treating DCBIs that have had direct hands-on experience through military deployments in Iraq and Afghanistan. Each chapter describes patient presentation and an algorithm outlining treatment with support from the literature. The text will conclude with three chapters. The first explores new advances in care that can be applied to these injuries. The second highlights the organization and team approach to care of these patients. Finally, the last chapter describes an actual case, cared for by the editors, that encompasses points from the chapters in the text. Extensive illustrations and flow diagrams are used throughout the text. This text is specifically designed to be a “how to” guide for inexperienced military and civilian providers. The chapters are organized in a step-wise fashion that mirrors the patient’s course from point of injury through their hospital course. Combining authors’ experience with illustrations and algorithm diagrams creates a text that is easy to use as a reference text or basis of training for future military and civilian surgeons.

"Managing Emergencies and Crises: Global Perspectives is primarily for graduate level students and instructors who study and research on a wide range of socio-economic and political issues related to the management of 'natural' disasters from a 'social disaster' perspective. From a broad perspective this book covers various concepts including prevention, preparedness, response, and recovery, as well as vulnerability and risk assessment that need to be understood by those in the emergency management field"-- Provided by publisher. "As the scale, frequency, and intensity of crises faced by the world have dramatically increased over the last decade, there is a critical need for a careful stocktaking on the knowledge of managing disasters. Managing Emergencies and Crises: Global Perspectives clearly and comprehensively explores the most important concepts of emergency and crisis management, such as mitigation, protection, prevention, preparedness, response, recovery, and vulnerability and risk assessment, and illustrates them with cases involving disasters and emergencies worldwide. Substantially revised, the Second Edition has been reorganized and includes two new and timely chapters on terrorism and emergency management and public health emergencies and crises. It also provides an emphasis on management and leadership and cross-sector governance from interdisciplinary and global perspectivesKey Features:- Two new chapters: Terrorism and Emergency Management and Public Health Emergencies and Crises. - Diverse scholarly perspectives are presented to guide readers' understanding of various concepts in the emergency and crisis management field. - Rich and diverse case studies illustrate how various stakeholders, including emergency program managers, respond in crisis and emergency management situation. - Navigate eBook Access (included with the print text) provides online or offline access to the digital textbook"-- Provided by publisher.

Many primary care clinicians are busy to the point of being overwhelmed and there is not time to do thorough evaluations on every patient. The outpatient clinician must be able to quickly identify and manage the overtly ill but also those with potential or even hidden issues that require a referral to the emergency department. This book provides a concise yet comprehensive summary of the various conditions the primary care practitioner could encounter in his/her office that require emergency department referral. Organized system by system, this manual provides short, readable yet detailed descriptions of situations where the clinician must make the quick decision to escalate the level of care. The book is comprised of thirteen main sections, each detailing a medical specialty and is further broken down into specific conditions within these specialties. The specialties that are featured are cardiology, dermatology, endocrinology, gastroenterology, HEENT, hematology and oncology, infectious disease, nephrology, neurology, gynecology, ophthalmology, psychiatry, pulmonology and urology. The chapters are broken down into five key aspects. First, a brief synopsis of the problem is identified covering the incidence, the risk factors and general information to give the clinician the insight to manage the situation. Next, there is a review of key elements of the history that can elucidate whether the patient has or does not have the emergent condition. Physical exam findings that the clinician can look for during the evaluation are then discussed followed by diagnostics that the clinician can get quickly the same day to help evaluate the situation. Lastly, treatments that can be provided while waiting for the urgent or emergent condition to be evaluated are identified. Written by experts in the field, Managing Emergencies in the Outpatient Setting is a valuable resource for primary care physicians, physician assistants and nurse practitioners alike. .

"Gout has been a well-known disease for over 2000 years, and is the most common cause of joint inflammation in adult males. It has become apparent that no therapeutic target based on hyperuricemia outcome had been defined. Very few controlled trials were available to test the efficacy and safety of treatments, and no research on diagnosis and management had been done despite data showing that patients with gout were generally improperly treated even in the hands of specialists. In the last 10 years, good-quality evidence on gout impact and management has grown exponentially, renal transporters have been recently identified, and a number of new drugs have been approved or are under current development. This handbook discusses these developments and the future of gout treatment, which now looks promising."--Publisher's website.

Certain organ toxicities can be severe and life-threatening. Therefore, it is crucial to recognize these disease entities early on to provide prompt and effective treatments to improve the quality of patient care, and enable the continuation of cancer therapy long-term. A clinical handbook with a particular focus in this field is lacking. This handbook focuses on the comprehensive, systematic review of clinical aspects of immunotherapy-induced toxicities in 15 major organ systems. The organs covered include endocrine, eye, gut, heart, kidney, liver, lung, muscular-skeletal, neuro, pancreas and skin etc. A unique feature about this book is the inclusion of perspectives from Anesthesiology, Infectious Disease, and Pathology besides specific organ toxicity management. The contributors are a group of experts offering routine clinical care to patients with most complex and refractory toxicity conditions, conducting pioneering research, and providing the guidance for the clinical practice to the peers and trainees in the field. The topics of each chapter include incidence, clinical presentations, evaluation, management, and long term follow up of each disease entity. There is also a simplified management algorithm or table illustrated in each chapter as well as audio PowerPoint slide deck to provide straightforward general instruction on the evaluation and treatment.

Foreword -- About this book -- What is new in this edition? -- Introduction: keeping healthy -- How infection spreads -- Infection control measures -- Health of teachers/caregivers and other staff members -- Recognizing the ill child: inclusion/exclusion criteria -- Signs and symptoms chart -- Quick reference sheets -- Role of the health consultant in child care and schools -- Immunization schedule and information -- Infectious disease outbreaks, epidemics, and bioterrorism/environmental health emergencies -- Sample letters, forms, and relevant resources -- Glossary -- Index.

This award-winning guide provides child care directors, teachers, and caregivers with essential information on the prevention and management of infectious diseases in group care settings. The newly revised and updated fifth edition is aligned with the most recent version of the premier AAP source of information on infectious diseases, Red Book®: 2018-2021 Report of the Committee on Infectious Diseases, 31st Edition.

This all-new point-of-care clinical support chart aids physicians in responding to the mental health needs of their patients encountered in everyday practice.

This text will provide readers with a thorough review of the complex condition of chronic pain and addictions. The book was originally commissioned due to the need in the field for more literature on the topic. This concise pocket book will review epidemiology, clinical features, diagnosis, and medical management of both chronic pain and addiction. Busy healthcare professionals will benefit from this text, which will not only cover the foundation of the management of both conditions and together, but discuss up-to-date national and international treatment guidelines, upcoming therapies and REMS.

Introduction to obesity -- understanding a patient with obesity -- preventative care and behaviour modification -- medical management of the patient with obesity -- surgical management of the patient with obesity -- long-term support for the patient with obesity.

As the number of people aged 65 years and above rises, physicians are increasingly confronted by elderly patients with impaired renal function, altered drug metabolism and multiple comorbidities. This book examines in detail the nature of renal injury in the elderly and its optimal management. A wide range of key topics are covered, including end-stage renal disease, diabetic nephropathy, acute kidney injury, drug metabolism and renal toxicity, dialysis and its complications and the use of renal transplantation. In addition, the assessment of glomerular filtration rate in the elderly and the role of novel renal biomarkers are carefully examined. Quality of life issues, the significance of other age-related medical problems and end of life care are also discussed. This book will be of value not only to nephrologists but also to general practitioners, medical students, intensivists, cardiologists, pharmacologists and those working in related specialties.

Low back pain is described as a very common condition that tends to affect about 70% of the population at some point in time with varying degrees of symptom severity. Although definitions vary, sciatic pain is generally defined as back-related pain radiating to the leg (normally below the knee and into the foot and toes) and is one of the commonest variations of low back pain. Patients with sciatica typically experience a more persistent and severe type of pain, a less favorable outcome, consume more healthcare resources and have more prolonged disability and absence from work than those with low back pain alone. Managing Sciatica and Radiculopathies in Primary Care Practice provides a comprehensive, up-to-date overview of the subject and key information for primary care practitioners about low back pain in patients, including definitions and causes, current management approaches, diagnostic and treatment algorithms, as well as clinical practice guidelines.

Collaborative assessment and management of suicidality: a suicide-specific clinical intervention within contemporary health care -- The SSF and the evolution of CAMS -- Systems of clinical care and optimizing the use of CAMS -- CAMS risk assessment: the collaborative use of the SSF -- CAMS treatment planning: coauthoring a suicide-specific treatment plan -- CAMS interim sessions: tracking suicide risk assessments and treatment plan updates -- CAMS clinical outcomes and disposition: lessons in living and a postsuicidal life -- CAMS as a means of decreasing malpractice liability -- CAMS adaptations and future developments.

"The menopause marks the permanent cessation of menstruation and heralds the transition in a woman's life from a reproductive state to a non-reproductive one. Whilst the average age of this landmark varies slightly across the world, the menopause generally occurs in the early 50s, and is only truly affected by factors such as smoking, and medical and surgical induction of the menopausal state. However, clinical symptoms may precede this, and the physiological changes which occur with the menopausal transition may begin several years prior to the onset of any manifestations. The basis of the clinical and biochemical changes associated with the perimenopausal period is the depletion of ovarian follicles to a critical level"-- Provided by publisher.

A pioneering guide for the management of tics and habit disorders Managing Tic and Habit Disorders: A Cognitive Psychophysiological Approach with Acceptance Strategies is a complete client and therapist program for dealing with tics and habit disorders. Groundbreaking and evidence-based, it considers tics and habit disorders as part of the same spectrum and focuses on the personal processes that are activated prior to a tic and habit rather than the tic or habit itself. By drawing on acceptance and mindfulness strategies to achieve mental and physical flexibility in preparing action, individuals can release unnecessary tension, expend less effort and ultimately establish control over their tic or habit. The authors explain how to identify the contexts of thoughts, feelings and activities that precede tic or habit onset, understand how self-talk and language can trigger tic onset, and move beyond unhelpful ways of dealing with emotions - particularly in taking thoughts about emotions literally. They also explore how individuals can plan action more smoothly by drawing on existing skills and strengths, and overcome shame by becoming less self-critical and more self-compassionate. They conclude with material on maintaining gains, developing new goals, and creating a more confident and controlled lifestyle. Managing Tic and Habit Disorders is a thoughtful and timely guide for those suffering from this sometimes all-consuming disorder, and the professionals who set out to help them.

This book is a practical guide to the performance of ultrasonography in women of reproductive age for the diagnosis and treatment of infertility. The coverage includes the use of ultrasonography for evaluation of the various disorders associated with infertility, such as endometriosis, anovulatory disorders, tubal disease, and adenomyosis; its role in assisted reproductive techniques; and its application to assess the viability and early complications of pregnancy. The more recent advances in the field are all addressed, including assessment of ovarian reserve, new classifications of uterine malformations using three-dimensional ultrasonography, and novel ultrasonographic modalities for the evaluation of tubal patency. Within each chapter, the focus is especially on the performance of the ultrasound examination, with highlighting of useful technical tips. The contributors are acknowledged experts from across the world, and the book will be of value for physicians, ultrasonographers, and other medical staff involved in caring for patients with fertility issues.

This book is a practical clinical guide to the correct diagnosis and appropriate treatment of hyperandrogenism, an extremely common endocrine disease that can affect women from adolescence to menopause. The volume covers topics ranging from the causes to the treatment, providing an expert point of view on the assessment and the differential diagnosis. Since the hyper androgenic syndromes are often associated with menstrual disorders, it is a valuable and easy-to-use resource, not only for endocrinologists but for gynecologists as well. Thanks to its clear approach, it is also useful for all specialists who deal with this women's disease.

This practical and generously illustrated text presents the current concepts regarding the management of the mangled extremity, including microsurgery, vascular surgery, free tissue, nerve, hand, and replantation surgery. Since the advent of microsurgical reconstruction, significant progress has been made in the areas of replantation, free tissue transfer, as well as the refinement of skeletal fixation techniques. The scope will encompass the initial triage of a patient with a mangled upper or lower extremity, the initial and subsequent reconstructive efforts, to include skeletal fixation, vascular and soft tissue reconstruction, muscle and tendon transfers, psychological impact, therapy requirements, amputation considerations, and current data on salvage versus amputation in these scenarios. Case examples will be included to add further depth and context to the techniques and recommendations provided. Presenting these surgical challenges in detail, The Mangled Extremity will be an ideal resource for orthopedic and trauma surgeons, residents and fellows, as well as emergency surgeons facing these intense, traumatic injuries.

This book represents the first comprehensive compilation of deliberations on botany; genetic resources; genetic diversity analysis; classical genetics & traditional breeding; in vitro culture & genetic transformation; detailed information on molecular maps & mapping of economic genes and QTLs; whole genome sequencing of the nuclear genome and sequencing of chloroplast genome; and elucidation of functional genomics. It also addresses alternate flowering, a unique problem in mango, and discusses currently available genomic resources and databases. Gathering contributions by globally reputed experts, the book will benefit the students, teachers, and scientists in academia and at private companies interested in horticulture, genetics, breeding, pathology, entomology, physiology, molecular genetics and breeding, in vitro culture & genetic engineering, and structural and functional genomics.

From the difficult to diagnose to the difficult to treat, Manson's Tropical Diseases prepares you to effectively handle whatever your patients may have contracted. Featuring an internationally recognized editorial team, global contributors, and expert authors, this revised and updated medical reference book provides you with the latest coverage on parasitic and infectious diseases from around the world. Incorporate the latest therapies into your practice, such as recently approved drugs and new treatment options.Find what you need easily and apply it quickly with highlighted key information, convenient boxes and tables, extensive cross-referencing, and clinical management diagrams.

Pt. 1. La Muestra; El Examen microscópico.--pt. 2. El Cultivo del Mycobacterium tuberculosis.--pt. 3. Sensibilidad del Mycobacterium tuberculosis a lsa drogas; La Identificación de micobacterias.--pt. 4. La Organización de los laboratorios de bacteriología de la tuberculosis; medidas de seguridad.

1. Enfermedades infecciosas y diatésicas. Intoxicaciones. Enfermedades de la sangre / [por C. Doptor, ... et al.] -- 2. Enfermedades del aparato respiratorio. Enfermedades del aparato circulatorio / por M. Loeper ... [et al.].

Introduction and overview of evidence-based CBT supervision -- Guiding principles behind our CBT supervision manual -- The context for CBT supervision -- Training CBT supervisors -- The alliance in CBT supervision -- Goal-setting in CBT supervision -- Facilitating learning in CBT supervision -- Feedback and evaluation in CBT supervision -- Support and guidance in CBT supervision -- Concluding remarks -- Appendix: Video catalogue -- Index.

Medical history -- Measurement of vision and refraction -- Neuro-ophthalmology -- External structures -- The orbit -- Slit lamp examination and glaucoma -- The retina and vitreous.

"The eye exam depends on many sophisticated, and costly instruments, together with highly trained professionals to operate them. Ophthalmologist - The ophthalmologist attended 4 years of college, 4 years of medical (MD) or osteopathic (DO) school, and 3 years of specialty eye residency training. They may remain general ophthalmologists, but now, more often than not, spend an additional 1-2 years subspecializing in corneal and external disease, vitreoretinal disease, cataracts, glaucoma, neuro-ophthalmology, oculoplastic surgery, pathology, pediatric (strabismus), or uveitis. Optometrist (OD) - The optometrist completes 4 years of college and 4 years of optometry school. They perform similar tasks to the ophthalmologist, with subspecialty fellowships similar to ophthalmology, but with stress on medical, rather than surgical skills.Opticians (ABO, American Board of Opticians) - Opticians grind the lenses and put them in frames (laboratory optician) or fit them on the patient (dispensing optician). Their training and certification is highly variable from state to state, but often includes 2 years at a community college. Ocularists (BCO, BRDO, FASO) - Ocularists are few in number and often learn their craft by apprenticeship. They have to pass tests for certification. Their job is to fit the rarely needed sclera shell after removal of an eye. (Fig. 423-426). Ophthalmic technicians - Ophthalmic technicians have varying degrees of licensure. With medical supervision, they may take medical histories; measure eye pressure; do refractions and visual field testing; take visual activities; teach contact lens fitting; and often assist in using the following diagnostic tests"-- Provided by publisher.

"Clinical Practice Manual for Pulmonary and Critical Care Medicine, by Judd W. Landsberg, MD, is a unique point-of-care manual that provides essential information on managing inpatients and outpatients with common, serious respiratory and internal medicine presentation and problems. Easy-to-follow diagnostic and therapeutic algorithms are accompanied by case-based illustrations encountered on a daily basis by attendings, fellows, residents, and students. The bulleted format, concise approach, and familiar examples provide a framework for effective teaching, learning, and patient care"--Publisher's description.

"Advances in technology, research, and evidence-based practice have led to improvements in the care of patients receiving radiation therapy. The knowledge and expertise required by nurses must focus on the needs of patients who come into their care at any point across the trajectory of the cancer journey. Nurses may work with patients at varying stages of the radiation therapy process and in a wide range of settings. Regardless, however, the need to be knowledgeable about the symptoms and side effects associated with this treatment is essential for nurses caring for this patient population. The Oncology Nursing Society has published the fifth edition of Manual for Radiation Oncology Nursing Practice and Education to support nurses who care for patients who will receive, are receiving, or have received radiation therapy. The fifth edition features significant updates and changes to the content to reflect advances in technology, treatment options, and symptom manage¬ment. New sections have been added based on input from radiation oncology nurses or as a result of changes in treatment options, the needs of specific patient populations, and observations from clinical practice. New topics include patients with cognitive changes and dementia; general distress and coping; patients with mental illness; special populations, such as women who are pregnant, ado-lescents, and young adults; special needs related to late effects of treatment and cardiac toxicities; and treatment modalities, includ¬ing cobalt therapy and immunotherapy. This manual serves as an essential resource for individual nurses new to working in a radiation therapy set¬ting as well as to nurses wanting to advance their knowledge in radiation biology and protection, diverse radiation therapy modalities, combination treatments, site- or disease-specific concerns, symptom management, special populations, and care during transition points. Additionally, this manual can be a resource to advanced practice clinicians, educators, and administrators, with a focus on support for nursing staff seeking the education and skills required to care for patients receiving radiation therapy and their families"-- Provided by publisher.

Ultrasound has rapidly become integral to the practice of emergency medicine. Over the past few years, with improvements in device size and cost, there has been increasing interest in exploring the utility of ultrasound in the prehospital environment. Much of the available literature on ultrasound in the emergency setting focuses on care delivered in emergency departments and intensive care units within the developed world. As a result, most resources are inappropriate and inadequate for doctors and non-physicians practicing in out-of-hospital environments that, by definition, are resource limited. This manual fills that gap by focusing on simplified discussions of ultrasound studies, ultrasound physics, and research that impacts out-of-hospital care in order to meet the needs of prehospital and austere providers. The manual discusses the use of ultrasound for diagnosis in out-of-hospital care, advanced noninvasive monitoring of patients, and safety in performing procedures common to the prehospital and austere environment. As is the approach for prehospital education, the chapters are complaint based and not diagnosis based where applicable. Chapters cover ultrasound image interpretation and basic physics; common image adjustments to improve image quality; unique challenges found in urban prehospital environments, austere/wilderness environments, tactical environments, and military special operations environments; and initial training, quality improvement/assurance programs, and credentialing. It also includes a section on procedures such as pericardiocentesis, vascular access, cricothyroidotomy, and others specific to austere providers. The Manual of Austere and Prehospital Ultrasound is an essential resource for physicians and related professionals, residents, and medical students in emergency medicine, civilian and military EMS providers, and critical care flight paramedics and nurses.

Cardiac Physical Examination in the Cardiac Intensive Care Unit -- Acute Myocardial Infarction -- Acute Myocardial Infarction: Adjunctive Pharmacologic Therapies -- Right Ventricular Myocardial Infarction -- Mechanical Complications of Acute Myocardial Infarction -- Cardiogenic Shock -- Acute Heart Failure and Pulmonary Edema -- Acute Fulminant Myocarditis -- Stress (Takotsubo) Cardiomyopathy -- Cardiorenal Syndrome Type 1 -- Sudden Cardiac Death -- Ventricular Tachycardia -- Diagnosis and Treatment of Unstable Supraventricular Tachycardia -- Acute Presentations of Valvular Heart Disease -- Hypertensive Emergencies -- Acute Aortic Syndromes -- Inotropic and Vasoactive Agents -- Intensive Diuresis and Ultrafiltration -- Antidysrhythmic Electrophysiology and Pharmacotherapy -- Central Venous and Arterial Access Procedures -- Temporary Cardiac Pacing -- Pericardial Tamponade -- Invasive Hemodynamic Monitoring -- Temporary Mechanical Circulatory Support Devices -- Ventricular Assist Device Therapy in Advanced Heart Failure.

I. Introductory aspects -- II. Cardiac problems as a consequence of cancer -- III. Oncologic treatments and cardiotoxicity -- IV. Cardiac tumors -- Improving the cooperation between oncologists, cardiologists, and general practitioners.

"Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. An ideal reference for residents, fellows, practitioners, and nurse practitioners, Manual of Cardiovascular Medicine, 5th Edition is a concise, up-to-date overview of key topics in cardiology. Using a practical, outline format, this best-selling title presents evidence-based approaches to cardiovascular diagnosis, diseases, and treatment - perfect for daily practice or exam preparation. A new, larger format and content that is thoroughly up to date; organized by disease and treatment so you can find what you're looking for quickly. With a focus on guidelines and the evidence basis for cardiovascular disease management, coverage includes approaches to common clinical syndromes and investigations, including drug therapy. Updated content with the latest innovations in cardiovascular medicine- including percutaneous approaches to valve disease, device management of cardiogenic shock, and the heart in the athlete. Clear diagrams, high-quality ECGs, and helpful summary tables provide excellent visual reinforcement to the text. Authoritative perspectives from the experienced staff and fellows at the Cleveland Clinic provide practical guidance in performance of common cardiovascular procedures and integration of devices.Enrich Your eBook Reading Experience with Enhanced Video, Audio and Interactive Capabilities! Read directly on your preferred device(s), such as computer, tablet, or smartphone Easily convert to audiobook, powering your content with natural language text-to-speech Adapt for unique reading needs, supporting learning disabilities, visual/auditory impairments, second-language or literacy challenges, and more"-- Provided by publisher. "The 5th edition of the Manual of Cardiovascular Medicine has been extensively updated and revised"-- Provided by publisher.

Introduction: why proteomic is important to you and the broad scientific community -- State-of-the-Art in Cardiac Proteomics -- Pitfalls to be avoided in experimental design -- Proteomic workflow: one size does not fit all -- Bottom-up Proteomics -- Top-Down Proteomics -- Targeted Proteomics -- Data Analysis and Data Mining -- Post-translational Modifications in the Cardiac Proteome -- Taylored Approaches to Study Post-translational Modifications -- Concluding Remarks: Proteomics AD 2025.

This manual gives information on the causative organisms, epidemiology and clinical features of all important childhood infections. It includes guidance on the clinical management of the infections and on steps to be taken to prevent future cases.

Section I. Practice of anesthesiology -- section II. Monitoring -- section III. Equipment and procedures -- section IV. Pharmacology -- section V. Intraoperative fluid management and blood component therapy -- section VI. Neuraxial and regional anesthesia -- section VII. Anesthesia and comorbid diseases -- section VIII. Pediatric anesthesia -- section IX. Cardiac anesthesia -- section X. Obstetric anesthesia -- Section XI. Anesthetic concerns in other subspecialty anesthesia -- section XII. Postoperative concerns in anesthesia -- section XIII. Crisis management algorithms in anesthesia -- section XIV. Atlas of clincial procedures -- section XV. Atlas of preipheral nerve block procedures -- section XVI. Atlas of echocardiography.

V. 1: Sect. I: Diagnostic strategies and general topics -- Sect. II: Bacteriology -- Sect. III: Antibacterial agents and susceptibility test methods -- V. 2: Sect. IV: Virology -- Sect. V: Antiviral agents and susceptibility test methods -- Sect. VI: Mycology -- Sect. VII: Antifungal agents and susceptibility test methods -- Sect. VIII: Parasitology -- Sect. IX: Antiparastitic agents and susceptibility test methods.

Part I: General clinical examinations and routine procedures. Principles of horse handling for veterinarians: horse handling versus horse restraint -- Physical restraint of the horse for clinical procedures -- History and physical examination of the horse -- Venous blood collection -- Arterial blood collection -- Injection techniques -- Other routes of medication administration -- Placement and care of intravenous catheters -- Chemical restraint -- Aseptic technique -- Part II: Clinical procedures by body systems: digestive system. Oral and dental examination -- Perineural anesthesia for dental procedures -- Common dental procedures -- Nasogastric intubation -- Abdominocentesis -- Rectal examination -- Percutaneous cecal trocharization -- Gastroscopy and esophagoscopy -- Part III: Clinical procedures by body systems: respiratory system. Endoscopic examination of the upper respiratory tract -- Tracheostomy -- Nasopharyngeal sampling -- Nasotracheal intubation -- Endoscopy and catheterization of the guttural pouch for sampling and lavage -- Local bronchoalveolar lavage of adults and foals -- Transtracheal aspiration of adults and foals -- Part IV: Clinical procedures by body systems: locomotor system. Lameness examination. -- Perineural anesthesia of the limbs -- Arthrocentesis and intraarticular analgesia/anesthesia -- Intravenous regional limb perfusion in adult horses -- Collection of muscle biopsy in horses -- Examination of foot conformation and balance -- Limb bandages and splints -- Cast application -- Part V: Clinical procedures by body systems: reproductive system. Reproductive evaluation of the stallion -- Reproductive evaluation of the mare -- Artificial insemination -- Placement of Caslick's suture -- Evaluation and monitoring of the pregnant mare -- Impending parturition and delivery -- Evaluation and monitoring of the post-parturient mare -- Part VI: Clinical procedures in neonatal medicine. Restraining the neonatal foal -- Physical examination of the neonatal foal -- Electrocardiography in the neonatal foal -- Arterial blood pressure measurement in the neonatal foal -- Measurement of central venous pressure in the neonatal foal -- Pulse oximetry in the neonatal foal -- Cardiopulmonary cerebral resuscitation of the neonatal foal -- Arterial blood sampling in the neonatal foal -- Venous blood sampling in the neonatal foal -- Urinary catheter placement in the neonatal foal -- Cerebral spinal fluid collection in the neonatal foal -- Intravenous catheter placement in the neonatal foal -- Intraosseus needle placement in the neonatal foal -- Placement of a nasal insufflation tube in the neonatal foal -- Placement of a nasogastric tube in the neonatal foal -- Administration of enema in the neonatal foal -- Arthrocentesis and joint lavage in the neonatal foal -- Regional limb perfusion in the neonatal foal -- Part VII: Clinical Procedures by Body Systems: Urinary System. Urinary catheterization of adult male horses -- Urinary catheterization of mares -- Part VIII: Clinical procedures by body systems: ocular procedures. Equine ocular examination -- Ophthalmic nerve blocks -- Ophthalmic diagnostic procedures -- Ophthalmic therapeutic procedures -- Part IX: Clinical procedures by body systems: dermatological procedures. Brushing/grooming -- Cellophane tape preparation -- Skin scraping -- Dermatophilus preparation -- Fungal culture of superficial skin lesions -- Skin biopsy -- Onchocerca preparation -- Intradermal sweat testing -- Part X: Clinical procedures by body systems: neurologic procedures. Neurologic examination -- Epidural anesthesia and analgesia -- Equine field anesthesia -- Part XI: Clinical procedures by body systems: miscellaneous procedures. Bone marrow aspiration -- Saddle evaluation and fitting -- Pre-purchase examination -- Euthanasia.

Role of the U.S Food and Drug Administration (FDA) in the regulation of clinical microbiology devices / Kathleen B. Whitaker, Sally A. Hojvat, and Estelle Russek-Cohen -- Commercial blood culture systems and methods / Micheal L. Wilson, Melvin P. Weinstein, and L. Barth Reller -- Rapid devices and instruments for the identification of aerobic bacteria / Laura J. Chandler, P. Rocco LaSala, and Susan Whittier -- Rapid devices and instruments for the identification of anaerobic bacteria / Christopher L. Emery, Maria D. Appleman, Jean A. Siders, Thomas E. Davis (and Stephen D. Allen, deceased) -- Rapid antigen devices and instruments for the detection and identification of viruses / Wallace H. Greene, Marilyn A. Menegus, and Allan L. Truant -- Molecular tests for the identification of viruses / Scott Duong and Christine C. Ginocchio -- Viral hepatitis / Emily Cartwright and Yun F. (Wayne) Wang -- Human papillomaviruses / N. Esther Babdy -- Human immunodeficiency virus / Richard L. Hodinka -- Chlamydia / Claudiu I. Bandea, Robert C. Jerris, and Carolyn M. Black -- Mycoplasma / Ken B. Waites and Cecile Bbar -- Commercial methods for identification and susceptibility testing of fungi / Stephen A. Moser and Jason Wicker -- Mycobacteria / Xiang Yang Han -- Diagnostic medical parasitology / Lynne S. Garcia and Gary W. Procop -- Molecular microbiology / Raghava Potula and Yi-Wei Tang -- Automated immunoassay analyzers / Richard L. Hodinka and Matthew J. Binnicker -- Molecular typing instruments and methods / Ruth Ann Luna -- Commercial methods in clinical veterinary microbiology / Thomas J. Inzana, Xiang-Jin Meng, Tanja Opriessing, and Lora Ballweber -- Microbiology laborry information systems / Raymond D. Aller and Vincent Salazar -- Emerging infectious diseases / Brett Laurence, Julie Collins, Carolyn Fernandes, Rafik Samuel, and Byungse Suh -- Automated and manual systems for antimicrobial susceptibility testing of bacteria / Alan T. Evangelista and James A. Karlowsky -- Bioterrorism / James W. Snyder and Michael A. Pentella -- Clinical microbiology : looking ahead / Natalie N. Whitfield, Raquel M. Martinez, and Donna M. Wolk.

"Manual of Coronary Chronic Total Occlusion Interventions: A Step-by-Step Approach, Second Edition, is an easy to read reference for coronary chronic total occlusion interventions (CTO). Written by recognized national and international experts in the field, this reference compiles the steps necessary to preform, what pitfalls to watch out for, and troubleshooting tactics necessary for coronary chronic total occlusion interventions (CTO). This second edition is updated with new developments in the field. The 2nd edition covers techniques like the Carlino technique, "scratch and go", "BASE", double-blind stick and swap, and subintimal crush, along with tips about how to use the latest complex PCI equipment. It also covers recently published trials, CTO scores and hybrid series"--Publisher's description.

The most comprehensive cosmetic plastic surgery manual on body contouring surgeries explains in detail how to undertake body contouring procedures to remove excess fat deposits and sagging skin so as to improve the shape as well as the tone of the abdomen, back, thighs and other areas of the body, resulting in a body with smoother contours and providing an appropriate shape. It also describes the latest procedures including high definition and fine definition liposuction with the use of various technologies and body contouring after massive weight loss. It also contains chapters on important procedures of fat grafting along with live stem cells, and how they can only be harvested from the fat during liposuction. This surgical manual discusses all possible body contouring procedures in a step by step How To manner so as to help the novice Cosmetic Surgeons as well as seasoned and experienced Surgeons alike. The risks, complications along with pearls are discussed along with individual procedures with a series of step-by-step photographs and pre and post images and short video clips. This Manual in Cosmetic Surgery and Medicine sets the standard for doctors entering the field of aesthetic surgery and medicine. It is a reference book for people who are in practice as well as a step-by-step manual for students and young doctors wanting to pursue this field. The other volumes are on: Rhinoplastic procedures Intimate Genital procedures Non-Invasive Aesthetic procedures Breast reshaping Cosmetic procedures of the Face.

It's the ideal go-to reference for the clinical setting! Compact and easy to use, Manual of Critical Care Nursing, 6th Edition presents essential information on approximately 80 disorders and conditions, as well as concepts relevant to caring for all critically ill patients and functioning in the critical care environment. Award-winning clinical nurse specialists Marianne Baird and Sue Bethel separate the content first by body system and then by disorder, with each disorder including a brief description of pathophysiology, assessment, diagnostic testing, collaborative management, nursing diagnoses, desired outcomes, nursing interventions, and patient teaching and rehabilitation. A concise format presents the material in a way that reflects a practicing nurse's thought processes. - Publisher.

Manual of Diagnostic and Therapeutic Techniques for Disorders of Deglutition is a comprehensive multidisciplinary text bringing together the research and practice of deglutition. This book is designed as a diagnostic and therapeutic reference for swallowing clinicians from such diverse backgrounds as gastroenterology, speech language pathology, otolaryngology, rehabilitation medicine, radiology and related fields. Manual of Diagnostic and Therapeutic Techniques for Disorders of Deglutition covers information on state-of-the-art diagnostic and therapeutic modalities through contributions from 28 innovators and master clinicians for the benefit of patients and providers alike. It concisely organizes the wealth of knowledge into one comprehensive information platform.This book is an essential reference for all deglutologists, clinicians, and researchers in their areas of expertise.

Volume 1 -- Chapter 1. Basic physics of ultrasound -- Chapter 2. Examination technique -- Chapter 3. Interventional ultrasound -- Chapter 4. Neck -- Chapter 5. Chest -- Chapter 6. Abdominal cavity and retroperitoneum -- Chapter 7. Liver -- Chapter 8. Gallbladder and bile ducts -- Chapter 9. Pancreas -- Chapter 10. Spleen -- Chapter 11. Gastrointestinal tract -- Chapter 12. Adrenal glands -- Chapter 13. Kidneys and ureters -- Chapter 14. Urinary bladder, urethra, prostate and seminal vesicles and penis -- Chapter 15. Scrotum -- Chapter 16. Special aspects of abdominal ultrasound. Volume 2 -- Chapter 1. Safety of diagnostic ultrasound -- Chapter 2. Obstetrics -- Chapter 3. Gynaecology -- Chapter 4. Breast -- Chapter 5. Paediatric ultrasound -- Chapter 6. Musculoskeletal ustrasound.

"Highlighted by thousands of outstanding photographs and schematic illustrations, this step-by-step guide to endoscopic sinus and skull base surgery is ideal for all specialists who need to stay current in the field. In this expanded second edition, practitioners will not only find basic and advanced procedures in endoscopic sinus surgery (including key criteria for patient selection), but also four entirely new chapters on anterior skull base surgery that reflect important recent developments. Special features of the second edition: 30% larger, with nearly 1500 endoscopic images and corresponding line drawings that make every procedure easy to visualize. Provides a practical management approach that leads to optimal outcomes: Who are the best candidates for specific procedures? When should medical treatment or surgery be used? Why should surgery be undertaken? How are the operative procedures performed? Covers the latest techniques for removal of skull base tumors and repair of skull base defects. Includes new chapters on pathophysiology of rhinosinusitis, sense of smell, applied anatomy, the endoscopically assisted bimanual operating technique (developed by the author), transorbital surgery, interdisciplinary teamwork, and more. Offers online access to 18 videos of endoscopically guided surgical procedures and patient interviews, for an excellent review and refresher. From diagnosis and preoperative counseling to evidence-based procedures, complication avoidance, and postoperative management, this book covers the gamut of topics clinicians face in everyday practice. All otolaryngologists, neurosurgeons, and maxillofacial surgeons will find it essential when making diagnostic and treatment decisions involving the skull base and paranasal sinuses"--Provided by publisher.

This book is an illustrated yet comprehensive compilation by experts in the field of fertility enhancing endoscopic surgery and assisted reproduction. This book catalogues full spectrum of diagnostic and operative hysteroscopy in the infertile population. The authors describe different techniques in various clinical conditions and review the recent evidence based literature supporting them. All procedures are explained in clear and precise text supplemented with high quality color pictures.

The Manual of Geriatric Anesthesia is a practical guide for physicians, residents, and students interested in the care of the elderly patient undergoing surgery. Although primarily written for anesthesiologists, other perioperative physicians and nurses will also find the information highly valuable. Highlights of the text include concise and clear discussions of preoperative assessment, anesthetic administration, the immediate postoperative care, as well as the more classic 'geriatric' topics such as the hip fracture patient, cataract surgery, postoperative delirium, dementia, ethics and end of life care. Clinical geriatric principles are woven into the text so that the reader can develop skills in geriatrics and develop a broader understanding of terminology and principles used in geriatric medicine.

This book provides a much-needed, internationally oriented text, focusing on specific aspects of heart disease in women. Despite the large amount of information available, there is still considerable confusion regarding female patients. As such, the book highlights the health events that occur during aging in women and that may influence the future CVD risk. For instance, pregnancy-related disorders are important predictors for CVD risk in women, and inflammatory diseases like rheumatic, thyroid disorders etc, which also interfere with CVD risk, are also more common in women. Adopting a multidisciplinary approach, including gynecology and endocrinology, it offers separate chapters on female-specific manifestations of ischemic heart disease, such as Tako Tsubo CMP and spontaneous coronary artery dissections. The book also discusses the effects and side effects of important medications. The chapters are clearly formatted, making it easy for readers to find subjects of interest.