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  • Book
    Richard Bronson editor.
    Summary: Novel topics compiled in this one-of-a-kind volume provide tantalizing hints for clinical application through future translational research. Only recently have we come to ask what role the male might play in pregnancy loss and embryo implantation failure, beyond contributing an abnormal set of paternal chromosomes at fertilization. This volume explores the recent evidence that these conditions might also be related to the transmission of previously unrecognized chromosomal micro-deletions and duplications, or via the epigenetic dysregulation of early embryonic gene function by spermatozoal microRNAs or alterations in sperm DNA methylation patterning, or by DNA damage secondary to either reactive oxygen species or environmental toxicants. In addition, the composition of seminal plasma has been found to be highly complex, containing many factors that play important roles in altering the uterine environment and the female immune system permissive of embryo implantation and trophectoderm outgrowth leading to successful pregnancy. Coverage includes an examination of both spermatozoa and seminal fluid component factors.

    Contents:
    Preface
    Meiotic Non-disjunction
    Insights into the Origin and Significance of Aneuploidy in Human Spermatozoa
    Damage to Sperm DNA Mediated by Reactive Oxygen Species: Its Impact on Human Reproduction and the Health Trajectory of Offspring
    Small RNAs: Their Possible Roles in Reproductive Failure
    The Sperm Epigenome, Male Aging and Potential Effects on the Embryo
    The Role of Uterine NK Cells in Normal Reproduction and Reproductive Disorders
    Seminal fluid Signaling in the Female Reproductive Tract: Implications for Reproductive Success and Offspring Health
    Role of Seminal Plasma in Human Female Reproductive Failure: Immunomodulation, Inflammation and Infections
    Human Leukocyte Antigen-G Within the Male Reproductive System
    Implications for Reproduction
    Prostasomes
    Their Characterization: Implications for Human Reproduction
    The Paternal Contribution to Fetal Tolerance
    Index.
    Digital Access Springer 2015