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  • Book
    Fred Saad, Mario A. Eisenberger, editors.
    Summary: This volume provides new data about the molecular biology of CRPC and a review of the definition, staging and prognostic factors that define CRPC. The book features an in-depth review of proven therapeutic options, including bone-targeted therapies, immunotherapy, chemotherapy and hormonal based therapies. Combination therapy as well as novel targeted approaches presently under investigation are also reviewed. The text provides up-to-date guidelines and algorithms for the management of CRPC based on international guidelines presently available as well as evidence-based medicine. As a concise yet comprehensive summary of the current status of the field, Management of Castration Resistant Prostate Cancer serves as a very useful resource for physicians and researchers dealing with this challenging malignancy.

    Castration Resistant Prostate Cancer: A Rapidly Expanding Clinical State and a Model for New Therapeutic Opportunities
    Evolution of Clinical States and the Castration Resistant Clinical Paradigm
    Molecular Mechanisms of Prostate Cancer Progression after Castration
    New Imaging Modalities
    Androgen Receptor Biology in Castration Resistant Prostate Cancer
    The Androgen Receptor as a Therapeutic Target for Castration-Resistant Prostate Cancer
    Approaches Targeting Androgen Synthesis (CYP 17 inhibitors)
    Cytotoxic Chemotherapy (Taxanes and Taxane Combinations)
    The Emerging Role of Immunotherapy in Castrate Resistant Prostate Cancer
    Bone Targeted Therapy: Rationale and Current Status
    Radium-223 and Other Radiopharmaceuticals in Prostate Cancer
    Phase I/II targeted treatments
    Defining Clinical Endpoints in Castration-resistant Prostate Cancer
    Angiogenesis Inhibition in Castration Resistant Prostate Cancer
    Co-targeting Adaptive Survival Pathways
    Targeting the PI3K/AKT/mTOR Pathway in Prostate Cancer
    PARP Inhibitors
    Targeting C-Met/VEGF in Castration Resistant Prostate Cancer
    Epigenetics in Castration Resistant Prostate Cancer
    Undifferentiated Prostate Cancer and the Neuroendocrine Phenotype
    Strategies Addressing Quality of Life: Patient Reported Outcome and Symptoms Management
    Evidence-Based Therapeutic Approaches for mCRPC patients: Rational Sequence of Standard Treatment Options and Design for Future Drug Development.
    Digital Access Springer 2014