BookDaniel Pedro Cardinali.
Contents:
1. Brief history of the stone of madness
2. The prescientific stage of the pineal gland
3. The beginnings of the pineal scientific era: from the late nineteenth century of melatonin's discovery
4. Sleep/wake cycle: history and facts
5. When this chronicler enters the story: the 1960s
6. The stone of madness as a neuroendocrine organ and model: the 1970s
7. Peripheral innervation of neuroendocrine-immune system: the challenges to change of physiological paradigm
8. Melatonin as a potential therapeutic agent: the 1980s
9. Melatonin as a chronobiotic that opens the "gates of sleep": the 1990s
10. Melatonin and the "diseases of the soul": the stone of madness returns
11. Twenty-first century: the 24/7 society as an environmental mutation
12. Melatonin as a medicament for the 24/7 society: metabolic syndrome
13. Melatonin as a medicament for the 24/7 society: normal and pathological aging
14. Melatonin as a medicament for the 24/7 society: cancer
15. Melatonin as a nutraceutical
Epilogue
Index.