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  • Book
    Hiroyuki Isayama, Yousuke Nakai, Takashi Sasaki, editors.
    Summary: This comprehensive book presents the latest evidence-based data on pancreatobiliary malignancies, including the epidemiology, examination, treatment and endoscopic management. It explores a range of topics, such as risk factors, detection strategies, and novel treatment approaches like precision medicine and immunotherapy. Although there have been rapid improvements in the management of these diseases, the survival period has not yet reached a satisfactory level. This book will help those doctors needing to share the latest information with the patients and their families. It provides a wealth of practical information to help surgeons, endoscopists and oncologists as well as physicians, basic researchers and professionals at medical device and pharmaceutical companies broaden their understanding of the current treatment and management strategies for pancreatobiliary malignancies.

    Part I: Current Topics in Epidemiology and Examinations of Pancreatic Cancer and Cholangiocarcinoma
    1: Risk Factors for Pancreatic Cancer and Cholangiocarcinoma
    1.1 Risk Factors for Pancreatic Cancer
    1.1.1 Introduction
    1.1.2 Genetic Factors
    1.1.3 Pancreatic Disorders (Cystic Lesions and Chronic Pancreatitis)
    1.1.4 Epidemiological Factors
    1.1.5 Microbiome
    1.1.6 Discussion
    1.2 Risk Factors for Cholangiocarcinoma
    1.2.1 Introduction
    1.2.2 Microbiome (Infectious Diseases)
    1.2.3 Genetic Factors 1.2.4 Pancreatobiliary and Inflammatory Disorders
    1.2.5 Epidemiological Factors
    1.2.6 Discussion
    2: Detection Strategies and Examination of Early Pancreatic Cancer
    2.1 Introduction
    2.2 Clinical Features and Image Findings of Early-Stage PC
    2.3 Cytological Diagnosis of Early-Stage PC
    2.4 Pathological Features of Early-Stage PC
    2.5 Statements and Detection Strategies of Early-Stage PC in Japan
    2.6 Collaborations Between Specialists and General Practitioners for Early-Stage PC in Japan
    References 3: Biomarkers for Pancreatic Cancer and Cholangiocarcinoma
    3.1 Introduction
    3.2 Currently Used Biomarkers for PDAC and CCA
    3.3 Other Protein Markers for PDAC and CCA
    3.4 Circulating Tumor Cells
    3.5 Extracellular Vesicles
    3.6 Biomarker-Based Selection of Targeted Therapies
    3.7 Conclusion and Future Perspectives
    4: Recent Advances of Precision Medicine in Pancreatic Cancer and Cholangiocarcinoma
    4.1 Introduction
    4.2 Features of Two Reimbursed CGP Tests
    4.3 Required Tissue Samples
    4.4 Liquid Biopsy 4.5 Eligible Patients for CGP Test and Optimal Timing of Its Application
    4.6 Clinical Benefit of CGP Tests in Pancreatic Cancer
    4.7 Clinical Benefit of CGP Tests in Biliary Tract Cancer
    Part II: Anti-cancer Treatments for Pancreatic Cancer
    5: Chemotherapy for Locally Advanced and Metastatic Pancreatic Cancer
    5.1 Introduction
    5.2 Metastatic Pancreatic Cancer
    5.2.1 FOLFIRINOX
    5.2.2 Gemcitabine Plus Nab-Paclitaxel
    5.2.3 Selection Between FOLFIRINOX and Gemcitabine Plus Nab-Paclitaxel 5.2.4 Intraperitoneal Chemotherapy in Patients with Peritoneal Dissemination
    5.3 Locally Advanced Pancreatic Cancer
    5.4 The Role of Monotherapy
    5.5 Second-Line Chemotherapy
    5.6 Future Perspective
    6: Neoadjuvant Therapy for Resectable and Borderline Resectable Pancreatic Cancer
    6.1 Introduction
    6.2 Preoperative Estimation for Surgical Resectability
    6.3 Potentially Resectable Tumors
    6.4 Prospective Studies for NAT and Adjuvant Therapy
    6.5 Optimal Agent or Regimens for NAT for Potentially Resectable PA 6.6 Optimal Regimens for NAT: Chemotherapy or CRT?
    Digital Access Springer 2021