BookYinghong Wang, editor.
Summary: Certain organ toxicities can be severe and life-threatening. Therefore, it is crucial to recognize these disease entities early on to provide prompt and effective treatments to improve the quality of patient care, and enable the continuation of cancer therapy long-term. A clinical handbook with a particular focus in this field is lacking. This handbook focuses on the comprehensive, systematic review of clinical aspects of immunotherapy-induced toxicities in 15 major organ systems. The organs covered include endocrine, eye, gut, heart, kidney, liver, lung, muscular-skeletal, neuro, pancreas and skin etc. A unique feature about this book is the inclusion of perspectives from Anesthesiology, Infectious Disease, and Pathology besides specific organ toxicity management. The contributors are a group of experts offering routine clinical care to patients with most complex and refractory toxicity conditions, conducting pioneering research, and providing the guidance for the clinical practice to the peers and trainees in the field. The topics of each chapter include incidence, clinical presentations, evaluation, management, and long term follow up of each disease entity. There is also a simplified management algorithm or table illustrated in each chapter as well as audio PowerPoint slide deck to provide straightforward general instruction on the evaluation and treatment.
Contents:
Intro
Preface
Introduction
Contents
Contributors
Chapter 1: Anesthesia
General Recommendations
Organ-Specific Treatment Strategies
References
Chapter 2: Cardiology (Heart)
Available Immune Checkpoint Inhibitors
Cardiac Side Effect Profile of Immune Checkpoint Inhibitors
Mechanisms of Myocardial Toxicity
ICI-Associated Myocarditis
Timing Onset of Myocarditis
Diagnostic Testing Considerations in ICI-Associated Myocarditis
Troponin
Natriuretic Peptide
Electrocardiogram (ECG)
Echocardiography
Cardiac Magnetic Resonance (CMR) Imaging Endomyocardial Biopsy (EMB)
Management
Advanced Management
Conclusion
References
Chapter 3: Dermatology (Skin)
Epidemiology
Clinical Characteristics
Morbilliform/Maculopapular Rash (MPR)
Pruritus
Eczematous Dermatitis
Urticaria
Lichenoid/Lichen Planus-Like Eruption
Psoriasiform Dermatitis
Vitiligo
Granulomatous Dermatitis
Xerosis
Autoimmune Bullous Disorders
Severe Cutaneous Adverse Reactions
Erythema Multiforme (EM)
Neutrophilic Dermatoses
Sweet's Syndrome (Acute Febrile Neutrophilic Dermatosis)
Pyoderma Gangrenosum Follicular Eruptions
Rheumatologic Disease
Dermatomyositis and polymyositis
Mucosal Toxicities
Hair Toxicities
Nail irCAEs
Less Common irCAEs
Grover's Disease
Keratoacanthoma/Cutaneous Squamous Cell Carcinoma
Evaluation
Diagnostic Tests for Specific irCAEs
Bullous Pemphigoid
Dermatitis Herpetiformis
Pemphigus Vulgaris-Like Lesions
Urticaria
Hair Toxicities
Rheumatologic Diseases
Treatment
Treatment Pearls
Pruritus
Eczematous
Urticaria
Lichenoid
Psoriasiform
Vitiligo
Bullous Pemphigoid
Alopecia Mucosal Toxicities (Including Lichenoid Eruptions)
Nail Toxicities
Neutrophilic Dermatoses
Granulomatous
SCARs
Erythema Multiforme
Sarcoidosis
Treatment Recommendations
Long-Term Complication and Follow-Up
References
Chapter 4: Endocrine
Introduction
Checkpoint Inhibitor-Induced Hypophysitis
Epidemiology
Clinical Characteristics
Evaluation
Treatment
Long-Term Complications and Follow-Up
Thyroid Dysfunction
Epidemiology
Clinical Characteristics
Evaluation
Treatment
Long-Term Complications and Follow-Up Primary Adrenal Insufficiency
Epidemiology
Clinical Presentation
Treatment
Checkpoint Inhibitor-Induced Diabetes
Epidemiology
Clinical Characteristics
Evaluation
Treatment
Long-Term Complications and Follow-Up
References
Chapter 5: Gastroenterology (GI)
Epidemiology and Risk Factors
Type of ICI Agent
Type of Cancer
The Patient
Clinical Presentation and Evaluation
Clinical Presentation
Clinical Evaluation
Biochemical and Stool Evaluation
IMC, Infections, and Its Management
Imaging
Endoscopic Evaluation
Histologic Evaluation