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  • Book
    Yinghong Wang, editor.
    Summary: Certain organ toxicities can be severe and life-threatening. Therefore, it is crucial to recognize these disease entities early on to provide prompt and effective treatments to improve the quality of patient care, and enable the continuation of cancer therapy long-term. A clinical handbook with a particular focus in this field is lacking. This handbook focuses on the comprehensive, systematic review of clinical aspects of immunotherapy-induced toxicities in 15 major organ systems. The organs covered include endocrine, eye, gut, heart, kidney, liver, lung, muscular-skeletal, neuro, pancreas and skin etc. A unique feature about this book is the inclusion of perspectives from Anesthesiology, Infectious Disease, and Pathology besides specific organ toxicity management. The contributors are a group of experts offering routine clinical care to patients with most complex and refractory toxicity conditions, conducting pioneering research, and providing the guidance for the clinical practice to the peers and trainees in the field. The topics of each chapter include incidence, clinical presentations, evaluation, management, and long term follow up of each disease entity. There is also a simplified management algorithm or table illustrated in each chapter as well as audio PowerPoint slide deck to provide straightforward general instruction on the evaluation and treatment.

    Contents:
    Intro
    Preface
    Introduction
    Contents
    Contributors
    Chapter 1: Anesthesia
    General Recommendations
    Organ-Specific Treatment Strategies
    References
    Chapter 2: Cardiology (Heart)
    Available Immune Checkpoint Inhibitors
    Cardiac Side Effect Profile of Immune Checkpoint Inhibitors
    Mechanisms of Myocardial Toxicity
    ICI-Associated Myocarditis
    Timing Onset of Myocarditis
    Diagnostic Testing Considerations in ICI-Associated Myocarditis
    Troponin
    Natriuretic Peptide
    Electrocardiogram (ECG)
    Echocardiography
    Cardiac Magnetic Resonance (CMR) Imaging Endomyocardial Biopsy (EMB)
    Management
    Advanced Management
    Conclusion
    References
    Chapter 3: Dermatology (Skin)
    Epidemiology
    Clinical Characteristics
    Morbilliform/Maculopapular Rash (MPR)
    Pruritus
    Eczematous Dermatitis
    Urticaria
    Lichenoid/Lichen Planus-Like Eruption
    Psoriasiform Dermatitis
    Vitiligo
    Granulomatous Dermatitis
    Xerosis
    Autoimmune Bullous Disorders
    Severe Cutaneous Adverse Reactions
    Erythema Multiforme (EM)
    Neutrophilic Dermatoses
    Sweet's Syndrome (Acute Febrile Neutrophilic Dermatosis)
    Pyoderma Gangrenosum Follicular Eruptions
    Rheumatologic Disease
    Dermatomyositis and polymyositis
    Mucosal Toxicities
    Hair Toxicities
    Nail irCAEs
    Less Common irCAEs
    Grover's Disease
    Keratoacanthoma/Cutaneous Squamous Cell Carcinoma
    Evaluation
    Diagnostic Tests for Specific irCAEs
    Bullous Pemphigoid
    Dermatitis Herpetiformis
    Pemphigus Vulgaris-Like Lesions
    Urticaria
    Hair Toxicities
    Rheumatologic Diseases
    Treatment
    Treatment Pearls
    Pruritus
    Eczematous
    Urticaria
    Lichenoid
    Psoriasiform
    Vitiligo
    Bullous Pemphigoid
    Alopecia Mucosal Toxicities (Including Lichenoid Eruptions)
    Nail Toxicities
    Neutrophilic Dermatoses
    Granulomatous
    SCARs
    Erythema Multiforme
    Sarcoidosis
    Treatment Recommendations
    Long-Term Complication and Follow-Up
    References
    Chapter 4: Endocrine
    Introduction
    Checkpoint Inhibitor-Induced Hypophysitis
    Epidemiology
    Clinical Characteristics
    Evaluation
    Treatment
    Long-Term Complications and Follow-Up
    Thyroid Dysfunction
    Epidemiology
    Clinical Characteristics
    Evaluation
    Treatment
    Long-Term Complications and Follow-Up Primary Adrenal Insufficiency
    Epidemiology
    Clinical Presentation
    Treatment
    Checkpoint Inhibitor-Induced Diabetes
    Epidemiology
    Clinical Characteristics
    Evaluation
    Treatment
    Long-Term Complications and Follow-Up
    References
    Chapter 5: Gastroenterology (GI)
    Epidemiology and Risk Factors
    Type of ICI Agent
    Type of Cancer
    The Patient
    Clinical Presentation and Evaluation
    Clinical Presentation
    Clinical Evaluation
    Biochemical and Stool Evaluation
    IMC, Infections, and Its Management
    Imaging
    Endoscopic Evaluation
    Histologic Evaluation
    Digital Access Springer 2022