BookBernd Nilius, Veit Flockerzi, editors.
Contents:
v. 1. TRPs: truly remarkable proteins
The TRCP subfamily
TRPC1
TRPC2
TRPC3: a multifunctional signaling molecule
TRPC4 and TRPC4-containing channels
TRPC5
TRPC6: physiological function and pathophysiological relevance
Transient receptor potential canonical 7 (TRPC7)
The TRPV subfamily
TRPV1
TRPV2
TRPV3
The TRPV4 channel
TRPV5, a Ca2+ channel for the fine tuning of Ca2+ reabsorption
TRPV6 channels
The TRPM subfamily
TRPM1
TRPM2
TRPM3
TRPM4
TRPM5
TRPM6
TRPM7
TRPM8
The TRPA1, TRPML and TRPP subfamily
TRPA1
TRPML1: an ion channel in the lysosome
TRPML2 and mucolipin evolution
TRPML3
TRPP subfamily and polycystin-1 proteins
v. 2. TRPs as special cell sensors
Temperature sensing with TRPs
TRPs in mechano-sensing and volume regulation
TRPs as chemosensors (ROS, RNS, RCS, gasotransmitters)
Photosensitive TRPs
TRPs in taste and chemesthesis
TRPs and Pain
TRPs in hearing
TRPs in olfaction
General topics
Evolutionary conserved, multitasking TRP channels-lessons from worms and flies
Structural biology of TRP channels
High-resolution views of TRPV1 and their implications for the TRP channel superfamily
Physiological functions and regulation of TRPC channels
The TRPCs-STIM1-orai interaction
The TRPC family of TRP channels: roles inferred (mostly) from knockout mice and relationship to ORAI proteins
TRPs: modulation by drug-like compounds
TRP channels in reproductive (neuro)endocrinology
Modulation of TRP ion channels by venomous toxins
Phosphoinositide regulation of TRP channels
TRP modulation by natural compounds
What do we really know and what do we need to know: some controversies, perspectives, and surprises.