Books

Chapter 1. Importing and exporting data -- Chapter 2. Manipulating data -- Chapter 3. Statistical analyses -- Chapter 4. Graphics -- Chapter 5. R.

Rab family of GTPases / Guangpu Li and M. Caleb Marlin -- Bioinformatic approaches to identifying and classifying Rab proteins / Yoan Diekmann and José B. Pereira-Leal -- Rab-NANOPS : FRET biosensors for Rab membrane nanoclustering and prenylation detection in mammalian cells / Arafath Kaja Najumudeen ... [et al.] -- High-throughput assay for profiling the substrate specificity of Rab GTPase-activating proteins / Ashwini K. Mishraand David G. Lambright -- Measuring Rab GTPase-activating protein (GAP) activity in live cells and extracts / Ryan M. Nottingham and Suzanne R. Pfeffer -- Analysis of the interactions between Rab GTPases and class V myosins / Andrew J. Lindsay, Stéphanie Miserey-Lenkei, and Bruno Goud -- Assaying the interaction of the Rab guanine nucleotide exchange protein Sec2 with the upstream Rab, a downstream effector, and a phosphoinositide / Danièle Stalder and Peter J. Novick -- Kinetic activation of Rab8 guanine nucleotide exchange factor Rabin8 by Rab11 / Shanshan Feng ... [et al.] -- Ypt1 and TRAPP interactions : optimization of multicolor bimolecular fluorescence complementation in yeast / Zhanna Lipatova, Jane J. Kim, and Nava Segev -- Identifying a Rab effector on the macroautophagy pathway / Juan Wang ... [et al.] -- Functional analysis of Rab27A and its effector Slp2-a in renal epithelial cells / Takao Yasuda, Paulina S. Mrozowska, and Mitsunori Fukuda -- Small GTPases in acrosomal exocytosis / Matias A. Bustos ... [et al.] -- Rab antibody characterization : comparison of Rab14 antibodies / Andrew J. Lindsay and Mary W. McCaffrey -- Selective visualization of GLUT4 storage vesicles and associated Rab proteins using IRAP-pHluorin / Yu Chen and Jennifer Lippincott-Schwartz -- 3D time-lapse analysis of Rab11/FIP5 complex : spatiotemporal dynamics during apical lumen formation / Anthony Mangan and Rytis Prekeris -- In vitro and in vivo characterization of the Rab11-GAP activity of drosophila Evi5 / Carl Laflamme and Gregory Emery -- Characterization of the role Rab25 in energy metabolism and cancer using extracellular flux analysis and material balance / Shreya Mitra ... [et al.] -- Measurement of Rab35 activity with the GTP-Rab35 trapper RBD35 / Hotaka Kobayashi ... [et al.] -- Analysis of connecdenn 1-3 (DENN1A-C) GEF activity for Rab35 / Patrick D. Allaire, Peter S. McPherson, and Brigitte Ritter -- Assay of Rab17 and its guanine nucleotide exchange factor Rabex-5 in the dendrites of hippocampal neurons / Yasunori Mori and Mitsunori Fukuda -- Methods for analysis of AP-3/Rabin4' in regulation of lysosome distribution / Viorica Ivan and Peter van der Sluijs -- Determination of Rab5 activity in the cell by effector pull-down assay / Yaoyao Qi ... [et al.] -- Identification of the Rab5 binding site in p110[beta] : assays for PI3K[beta] binding to Rab5 / Rachel S. Salamon ... [et al.] -- Role of the Rab5 guanine nucleotide exchange factor, Rme-6, in the regulation of clathrin-coated vesicle uncoating / Elizabeth Smythe -- Differential effects of overexpression of Rab5 and Rab22 on autophagy in PC12 cells with or without NGF / M. Caleb Marlin and Guangpu Li -- Determining the role of Rab7 in constitutive and ligand- mediated epidermal growth factor receptor endocytic trafficking using single cell assays / Brian P. Ceresa -- Visualizing directional Rab7 and TrkA cotrafficking in axons by pTIRF microscopy / Kai Zhang, Praveen D. Chowdary, and Bianxiao Cui -- Quantitative bead-based flow cytometry for assaying Rab7 GTPase interaction with the Rab-interacting lysosomal protein (RILP) effector protein / Jacob O. Agola ... [et al.].

History of rabies research -- Rabies virus -- Epidemiology -- Molecular epidemiology -- Rabies in terrestrial animals -- Bat rabies -- Human disease -- Pathogenesis -- Pathology -- Immunology -- Laboratory diagnosis of rabies -- Measures of rabies immunity -- Rabies vaccines -- Next generation of rabies vaccines -- Public health management of humans at risk -- Therapy of human rabies -- Dog rabies and its control -- Rabies control in wild carnivores -- Blueprint for rabies prevention and control -- Future developments and challenges.

This book reviews the recent advances in rabies research and rabies vaccine development. The reader is introduced to biology and pathology of the virus, causing agents and the history of rabies vaccination. The book presents regional rabies prophylaxis programs and discusses vaccination strategies for wildlife and humans. Further, innate immune response as well as antibody response to rabies are examined. All chapters are written by renowned experts in rabies research, some of them part of the WHO Collaboration Centre for Rabies Surveillance and Research. The book targets researchers and health professionals working in Virology, Veterinary Medicine and Biomedicine.

Rabies is the deadliest zoonotic disease that threatens humans and animals on all continents except Antarctica. Asia and Africa are worst affected as more than 95 per cent of rabies associated human deaths occur in these regions. India alone bears about 36 per cent of the global human rabies burden. Dogs are the main transmitters of rabies that potentially threaten over 3 billion people in Asia and Africa. Many developed nations have been able to successfully control dog rabies but continue to face the risk from wildlife including bats.

Race, Work, and Leadership is a rare and important compilation of essays that examines how race matters in people's experience of work and leadership. What does it mean to be black in corporate America today? How are racial dynamics in organizations changing in a post-Obama era? How do we build inclusive organizations? Inspired by and developed in conjunction with the research and programming for Harvard Business School's 2018 celebration of the 50th anniversary of the founding of the HBS African American Student Union, this groundbreaking book shines new light on these and other timely questions and illuminates the present-day dynamics of race in the workplace. Contributions from top scholars, researchers, and practitioners in leadership, organizational behavior, psychology, sociology, and education test the relevance of long-held assumptions and reconsider the research approaches and interventions needed to understand and advance African Americans in work settings and leadership roles. At a time when there are fewer African American men and women in corporate leadership roles (following a peak in 2002), Race, Work, and Leadership will stimulate new scholarship and dialogue on the organizational and leadership challenges of African Americans and become the indispensable reference for anyone committed to understanding, studying, and acting on the challenges facing leaders who are building inclusive organizations.-- Provided by publisher.

"A Race Is a Nice Thing to Have: A Guide to Being a White Person or Understanding the White Persons in Your Life is designed to help White people fully recognize and accept their racial identity, assume the proper responsibility for ending racism, and develop an understanding of how racism impacts their own racial group. This powerful text encourages positive racial adjustment and deeper levels of self-understanding. The book explores the meaning of race in society, the "color-blindness" movement, the problem of ignorance about Whiteness, the various phases of internalized racism, and other critical topics. Evocative and meaningful activities throughout the text foster reflection and increased levels of self-awareness and acceptance. The third edition features updated references and charts, as well as a new foreword by Dr. Allen Ivey"-- Publisher description.

"First published in 1993, on the one-year anniversary of the Los Angeles riots, Race Matters became a national best seller that has gone on to sell more than half a million copies. This classic treatise on race contains Dr. West's most incisive essays on the issues relevant to black Americans, including the crisis in leadership in the Black community, Black conservatism, Black-Jewish relations, myths about Black sexuality, and the legacy of Malcolm X. The insights Dr. West brings to these complex problems remain relevant, provocative, creative, and compassionate. In a new introduction for the twenty-fifth-anniversary edition, Dr. West argues that we are in the midst of a spiritual blackout characterized by imperial decline, racial animosity, and unchecked brutality and terror as seen in Baltimore, Ferguson, and Charlottesville. Calling for a moral and spiritual awakening, Dr. West finds hope in the collective and visionary resistance exemplified by the Movement for Black Lives, Standing Rock, and the Black freedom tradition. Now more than ever, Race Matters is an essential book for all Americans, helping us to build a genuine multiracial democracy in the new millennium."--Amazon.com.

This book covers the key basics of tissue engineering as well as the latest advances in the integration of both antimicrobial and osteoinductive properties. Topics covered include osteoconductive and osteoinductive biomaterials (calcium phosphate, bone morphogenetic protein, peptides, antibodies, bioactive glasses, nanomaterials, etc.) and scaffolds. Research integrating both antimicrobial/biofilm-inhibiting and osteoinductive/osteoconductive properties and their co-delivery is detailed and their roles in clinical success are discussed. Combined with its companion volume, Racing for the Surface: Antimicrobial and Interface Tissue Engineering, this book bridges the gap between infection and tissue engineering, and is an ideal book for academic researchers, clinicians, industrial engineers and scientists, governmental representatives in national laboratories, and advanced undergraduate students and post-doctoral fellows who are interested in tissue engineering and regeneration, infection, and biomaterials and devices.

This book covers the latest research in biofilm, infection, and antimicrobial strategies in reducing and treating musculoskeletal, skin, transfusion, implant-related infections, etc. Topics covered include biofilms, small colony variants, antimicrobial biomaterials (antibiotics, antimicrobial peptides, hydrogels, bioinspired interfaces, immunotherapeutic approaches, and more), antimicrobial coatings, engineering and 3D printing, antimicrobial delivery vehicles, and perspectives on clinical impacts. Antibiotic resistance, which shifts the race toward bacteria, and strategies to reduce antibiotic resistance, are also briefly touched on. Combined with its companion volume, Racing for the Surface: Pathogenesis of Implant Infection and Advanced Antimicrobial Strategies, this book bridges the gaps between infection and tissue engineering, and is an ideal book for academic researchers, clinicians, industrial engineers and scientists, governmental representatives in national laboratories, and advanced undergraduate students and post-doctoral fellows who are interested in infection, microbiology, and biomaterials and devices.

"This book outlines the relationship between racism and health, while providing public health professionals with a variety of actions, strategies, and tools to understand and address the public health implications of racism, as well as inspiration to pursue health equity"-- Provided by publisher.

Eduardo Bonilla-Silva's acclaimed Racism without Racists is a provocative book that explodes the belief that America is now a color-blind society. The fifth edition includes a new chapter addressing what readers can do to confront racism, new material on the racial climate post-Obama, new coverage of the Black Lives Matter movement, and more.

"RadCases Gastrointestinal Imaging Second Edition by Stephen Thomas and Jonathan M. Lorenz expands on the rich study experience that has been tried, tested, and popularized by radiology residents around the world. This new edition includes important variations on prior cases, updated diagnostic and management strategies, and new pathological entities. One hundred new, carefully selected GI cases are focused on helping radiology residents navigate and assimilate a daunting volume of digestive-related information. For maximum ease of self-assessment, each case begins with the clinical presentation on the right-hand page; study that and then turn the page for imaging findings, differential diagnoses with the definitive diagnosis, essential facts, pearls and pitfalls, and more"-- Provided by publisher.

"This volume on Head and Neck Imaging will complete the corpus of content for the RadCases series. As with all RadCases volumes, Head and Neck Imaging contains 100 cases in the print book and an additional 150 cases online. The content covers the imaging of the various structures of the head and neck, including the temporal bone, the skull base, all ear and orbit structures, all nanasal structures and paranasal sinuses, the neck and its structures and glands, the larynx, etc. Following the proven RadCases format, each case begins with the clinical presentation on the first page, and the second page provides image findings, differential diagnoses, definitive diagnoses, essential facts, Pearls and Pitfalls, all with high-quality images. RadCases simulates what the resident finds on rounds, rotations, and exams"--Provided by publisher.

Nuclear Radiation, Ionization, and Radioactivity -- Radiation Exposure: Consequences, Detection, and Measurements -- Mathematical Modeling of Radiation -- Medical Imaging -- Basic Principles of Radiation Detectors -- Theoretical Approach of Crystal and Film Growths of Materials Used in Medical Imaging System -- Device Fabrication (Scintillators/Radiation Detectors) -- Characterization of Radiation Detectors (Scintillators) Used in Nuclear Medicine -- Instrumentation and Its Applications in Nuclear Medicine.

The role of disaster medicine is becoming more important as the frequency and severity of natural and technological disasters increase. The triple disaster that occurred in Fukushima on March 11, 2011 calls for innovation in the training of health care professionals, pre-hospital emergency care providers, and emergency personnel in the management of the medical consequences of radiation disasters. While many books are available on disaster medicine, none is specifically devoted to the role of physicians in the management of patients exposed to radiation leakage from a damaged nuclear power plant. Radiation Disaster Medicine aims to fill this void based on the response to the Fukushima nuclear accident. Each chapter addresses principles and practices of radiation medicine within the specific context of that accident. Topics covered include the role of physicians in radiation disasters, the concepts of external and internal exposure, prehospital and hospital response, disaster behavioral health, and radiation emergency response from the perspective of national and international institutions. Most of the contributors are active educators and researchers in radiation medicine with first-hand experience in dealing with prehospital triage and management of patients within secondary and tertiary care hospitals in Japan. It is hoped that this book will assist in attaining the ultimate goal of radiation disaster medicine: to help the patients.

This book covers every aspect of radiation myelopathy and considers the evidence from all species in which it has been studied. The historical and current understanding of the pathogenesis of this rare but devastating injury is first discussed. The evidence regarding the role of a variety of factors in radiation myelopathy is then reviewed. Readers will find detailed information on the impacts of total radiation dose, radiation volume, dose fractionation, hyper fractionation, age, anatomic level, comorbidities, radiation modifiers, other therapies, and retreatment of the spinal cord. Given the similarity of the pathogenesis of radiation myelopathy in humans and experimental animals, the potential for cross-species modelling of dose response is explored, with attention to relevant species differences. Treatment of the condition is also fully considered. New theories are presented regarding retreatment, small volume response, and the final step in white matter necrosis. The final chapter addresses the medicolegal issues elicited by radiation myelopathy, which is often the result of treatment error. Radiation Myelopathy will be of high value for radiation oncologists, radiation physicists, dosimetrists, biologists, neurologists, medical oncologists, and attorneys.

This book is an evidence-based guide to current use of radiation therapy for the treatment of malignancies at major disease sites. It is designed to meet the needs of residents, fellows, and practicing radiation oncologists and will assist in selection and delineation of tumor volumes/fields and dose prescription for intensity-modulated radiation therapy, including volumetric modulated arc therapy for stereotactic radiosurgery or stereotactic body radiotherapy. Each tumor site-related chapter presents, from the perspective of an academic expert, informative cases at different stages in order to clarify specific clinical concepts. The coverage includes case presentation, a case-related literature review, patient preparation, simulation, contouring, treatment planning, image-guided treatment delivery, follow-up, and toxicity management. The text is accompanied by illustrations ranging from slice-by-slice delineations on planning CT images to finalized plan evaluations based on detailed acceptance criteria. The expert knowledge and evidence contained in this comprehensive book will give readers the confidence to manage common cancers without outside referral and to meet the clinical challenges faced in everyday practice.

Pediatrics -- Central nervous system -- Eye -- Head and neck -- Thorax -- Breast -- Gastrointestinal -- Genitourinary -- Gynecology -- Hematology -- Bone -- Soft tissue sarcoma -- Skin -- Palliative -- Benign disease

Known among radiation oncology residents as "the green book," Radiation Oncology: A Question-Based Review is a must-have learning tool for trainees and physicians who want to strengthen their long-term command of radiation oncology. The updated 3rd Edition reflects state-of-the-art advances in the field, with revised questions and answers, new professional guidelines, and new annual content updates for the eBook. Offers detailed questions on the natural history, epidemiology, diagnosis, staging, treatment recommendations, and treatment-related side effects for each cancer type. Contains a new primer section on immunotherapy. Retains popular features such as memory aids, quick-reference tables, and useful facts from other relevant disciplines such as radiology, anatomy, and medical oncology. Incorporates the latest ASTRO, AJCC, and NCCN guidelines, as well as seminal new studies and practice-changing trials, to reflect current radiation oncology practice. Includes new annual updates to the eBook for the life of the edition, with revised questions or answers that keep you current with new knowledge in the field. Ideal for both trainees and radiation oncologists as a high-yield introduction and review of the clinical management of major cancer types and conditions that are currently treated with radiation. Enrich Your eBook Reading Experience with Enhanced Video, Audio and Interactive Capabilities! Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech. Adapt for unique reading needs, supporting learning disabilities, visual/auditory impairments, second-language or literacy challenges, and more."--Provided by publisher.

"Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Updated with details on the newest therapies and sporting a new full-color design, this latest edition of Radiation Oncology: Management Decisions continues to offer comprehensive guidance for residents as well as radiation oncologists already in professional practice. You'll discover the latest treatment plans for numerous cancer sites and tumor types, including the mouth and sinus, gastrointestinal areas, lungs, bones, and blood. Concise, easy-to-read material you can use in a clinical setting immediately with patients! Combines comprehensive overviews of basic concepts with the latest radiologic treatment regimens for a wide variety of tumor types and cancer sites. Now in full color! Bursting with hundreds of illustrations, figures, and images to illuminate visually important and state-of-the-art techniques. Heavily bulleted content format and to-the-point writing style makes content easy to digest and use with patients quickly. Chapters that address tumor- or site-specific treatments cover screening, assessment, staging, therapeutic developments, and other key information. Features an up-to-date list of commonly prescribed drugs--streamlined for easier reading--and coverage of the latest pain management and palliative treatments. Enrich Your eBook Reading Experience with Enhanced Video, Audio and Interactive Capabilities! Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech. Adapt for unique reading needs, supporting learning disabilities, visual/auditory impairments, second-language or literacy challenges, and more."--Provided by publisher.

Epidemiology of childhood brain tumors / Philip J. Lupo, Surya P. Rednam, and Murali Chintagumpala -- Histopathology of primary tumors of the central nervous system / Adekunle M. Adesina -- Imaging of pediatric central nervous system tumors / Edgar G. Ordonez-Rubiano, Rachel S. Hicklen, Laura Rivera-Osorio and Jason M. Johnson -- Surgical principles in the treatment of pediatric brain tumors / Eric N. Momin, Mahmood Khan, and Andrew Jea -- Chemotherapeutic strategies in brain tumors / Soumen Khatua -- Medulloblastoma / Arnold C. Paulino and Christian Carrie -- Supratentorial primitive neuroectodermal tumor / Mary Frances McAleer -- Atypical teratoid rhabdoid tumors (AT/RT) and ETMR / Susan L. McGovern -- Ependymoma / Rosangela Correa Villar and Thomas E. Merchant -- Low-grade glioma / Rolf-Dieter Kortmann and Arnold C. Paulino -- Optic pathway glioma / Julie A. Bradley, Ronny L. Rotondo, and Daniel J. Indelicato -- High-grade glioma / Scheryll Alken, Fernando Carceller, Henry Mandeville, and Frank Saran -- Brainstem tumors / Carolyn R. Freeman, Jean-Pierre Farmer, and Nada Jabado -- Central nervous system germinoma / Yuta Shibamoto and Shinya Takemoto -- Central nervous system nongerminomatous germ cell tumors / Ji Hoon Phi, Chuhl Joo Lyu, and Joo-Young Kim -- Craniopharyngioma / Andrew J. Bishop and David R. Grosshans -- CNS leukemia / Yi An and Kenneth B. Roberts -- Spinal tumors / Natia Esiashvili, Ronica Nanda, Mohammad Khan, and Bree Eaton -- Choroid plexus tumors / Arthur K. Liu, Todd Hankinson, and Johannes E. A. Wolff -- Proton therapy for skull base chordomas in the pediatric and adolescent patient / Eugen B. Hug -- Pituitary tumors : pituitary adenomas and langerhans cell histiocytosis associated diabetes insipidus / Ralph P. Ermoian -- Pediatric brain metastases / Radhika Sreeraman Kumar and Ronny L. Rotondo -- Anesthesia for immobilization / Pascal Owusu-Agyemang -- Image guidance in pediatric brain radiotherapy / Sara Alcorn and Stephanie Terezakis -- Conformal radiation therapy for pediatric CNS tumors / Thomas B. Daniels and Nadia N. Laack -- Proton therapy for pediatric brain tumors / Anita Mahajan -- Craniospinal irradiation / Bree R. Eaton, Judith Adams, and Torunn I. Yock -- Special radiation techniques for pediatric brain tumors / Susan M. Hiniker and Iris C. Gibbs -- Reirradiation / Patricia E. Daly and Normand J. Laperriere -- Neuropsychological late effects of radiotherapy for pediatric brain tumors / Marsha Nortz Gragert, Tanya N. Antonini, and Lisa S. Kahalley -- Endocrine sequelae of central nervous system irradiation / Steven G. Waguespack and Wassim Chemaitilly -- Ophthalmic outcomes for children treated with CNS radiation / Irene T. Tung and Jane C. Edmond -- Hearing / Paul W. Gidley -- Vascular late effects of cranial radiation / Christine Hill-Kayser and Louis Constine -- Second neoplasms after successful treatment for pediatric central nervous system tumors / Mark J. Amsbaugh and Shiao Y. Woo -- Afterword / Edward C. Halperin.

Organized by site, this book covers in detail all the sites and cancer types currently treated with radiotherapy. Detailed questions, organized in a "flash-card" format are included on the natural history, epidemiology, diagnosis, staging, treatment options and treatment-related side effects for each cancer type. Written in joint collaboration by residents and staff radiation oncologists at the Department of Radiation Oncology at the Cleveland Clinic Taussig Cancer Institute, the book contains more than 900 questions addressing the full gamut of the science and art of radiation oncology today. "Radiation Oncology Self- Assessment Guide" will feature: comprehensive coverage of radiation oncology; "Flash card" format that facilitates recall of key data, treatment assessment and patient management, and important original studies; and, all covered in the question sets.

Central Nervous System Tumors: Adult and Pediatric -- Skin Cancer -- Head and Neck Cancer -- Lung Cancer -- Tumors of the Mediastinum -- Breast Cancer -- Upper Gastrointestinal Cancers -- Lower Gastrointestinal Cancers -- Urinary System Cancers -- Male Genitourinary Cancer -- Gynecologic Malignancies -- Hematologic Malignancies -- Sarcoma -- Pediatric Non-central Nervous System Cancers -- Benign and Metastatic Disease.

Now in its second edition, this popular text remains a comprehensive study and review aid for the radiation oncology trainee and practicing radiation oncologist. The updated Radiation Oncology Study Guide, 2e maintains its robust Q&A format, and has been comprehensively updated to include the latest staging information and treatment methods. Answer rationales have been modified to a more readable, high yield bulleted format. Each chapter covers a major disease site and is divided into two main parts: Questions & Answers and Rationale. Questions review the scope of clinical practice, spanning from initial presentation to complications of treatment. General content and work-up questions emphasize "pearls" of epidemiology, anatomy, pathology, clinical presentation, and staging. Treatment content questions not only review evidence-based data guiding treatment recommendations, but also practical aspects of radiation treatment planning, pertinent radiobiology and physics, and complications of treatment. This book is an ideal resource for physicians-in-training to prepare for initial written and oral exams and physicians in practice to maintain their skills and prepare for maintenance of certification longitudinal and written exams.

This book explains clearly and in detail all aspects of radiation protection in nuclear medicine. After an introductory chapter on the general role of radiation protection, measurement quantities and units are discussed, and detectors and dosimeters, described. Radiation biology and radiation dosimetry are then addressed, with the inclusion of a chapter specifically devoted to biology and dosimetry for the lens of the eye. Discussion of radiation doses to patients and to embryos, fetuses, and children forms a central part of the book. Phantom models, biokinetic models, calculations, and software solutions are all considered, and a further chapter focuses on quality assurance and reference levels. Occupational exposure also receives detailed attention. Exposure resulting from the production, labeling, and injection of radiopharmaceuticals and from contact with patients is discussed and shielding calculations are explained. The book closes by considering exposure of the public and summarizing the "rules of thumb" for radiation protection in nuclear medicine. This is an ideal textbook for students and a ready source of useful information for nuclear medicine specialists and medical physics experts.

Methods of proteomics have been shown to be powerful tools in search of target proteins - proteins that respond in cells to an internal or an external stimulus. Proteomics is widely used in biomedical research. However, in radiation biology research, following exposures of living matter to low doses of either ionizing or non-ionizing radiation, proteomics approach is only very slowly gaining support. This book, by presenting the current status of the use of proteomics in radiation biology, will help to attract attention to the field of radiation proteomics.

The book covers all the radiation safety aspects while working with unsealed radionuclides. Radiation safety plays a significant role in routine nuclear medicine practices and is necessary to protect occupational workers, patients, members of the general public and the environment. A fair knowledge of radiation safety is expected from all nuclear medicine professionals. Chapters include basics of radiation physics, biological bases of radiation protection, planning and design of nuclear medicine facilities, cyclotron and high dose therapy facilities, radiation safety considerations in nuclear medicine, cyclotron while preparing radiopharmaceuticals. It also includes the working mechanism of radiation detectors, quality assurance of positron emission tomography (PET) and gamma camera, including single photon emission computed tomography (SPECT), emergency preparedness plan, nuclear medicine and CT dosimetry, transport regulations, the role of national regulatory authorities and radioactive waste management. The last chapter provides probable model questions asked in the radiological safety officer certification examination and includes 250 multiple-choice questions (MCQs), 100 true or false, 60 fill in the blanks, and 40 match the following questions. The book is written in a simple language for a better understanding of the occupational workers of any grade. It serves as reference material for nuclear medicine professionals on radiation safety, related to planning, quality assurance, dosimetry and various regulations pertaining to nuclear medicine. It is a ready reckoner for the students pursuing a degree/diploma in nuclear medicine and preparing for certification courses in radiation safety to understand the subject matter along with options to attempt practice questions.

This book is a collection of all pertinent information on radiation safety applicable in nuclear medicine and research using radioactive materials. Radiation exposure causes harm to humans and is strictly controlled by several regulatory authorities (NRC, FDA, EPA, DOT, etc). The practice of nuclear medicine involves the use of radioactive materials in patients and research, and is well regulated by these agencies. However, information on radiation safety practice in nuclear medicine and research areas is scattered throughout the literature and federal registers. For busy nuclear technologists and professionals, it is quite time consuming to look for and acquire specific information and instructions to follow in radiation-related occasions and incidents. This guide provides ready-made, handy information on radiation safety as required in the practice of nuclear medicine, presented in a concise form for easy understanding and quick reference related to a given situation and/or incident. This is an ideal reference for nuclear medicine physicians, nuclear medicine technologists, and researchers using radioactive materials.

1 Primary Central Nervous System Lymphomas -- 2 Ocular Adnexal Lymphoma -- 3 Extranodal NK/T Cell lymphoma, Nasal Type -- 4 Thyroid Lymphoma -- 5 Pyothorax-associated lymphoma (PAL) -- 6 Stomach -- 7 Intestinal lymphomas -- 8 Primary Testicular Lymphoma -- 9 Cutaneous Lymphomas.

Basics of Chemotherapy -- Esophageal Cancer: Clinical Data -- Esophageal Cancer: Contouring and treatment planning -- Gastric Cancer: Clinical Data -- Gastric Cancer: Contouring and treatment planning -- Pancreatic Cancer: Clinical Data -- Pancreatic Cancer: Contouring and treatment planning -- Primary Liver Cancer (hepatocellular carcinoma and Intrahepatic Cholangiocarcinoma): Clinical Data -- Primary Liver Cancer (hepatocellular carcinoma and Intrahepatic Cholangiocarcinoma): Contouring and treatment planning -- Biliary Cancer (Extrahepatic Bile Duct and Gallbladder): Clinical Data -- Biliary Cancer (Extrahepatic Bile Duct and Gallbladder): Contouring and treatment planning -- Colon Cancer: Clinical Data -- Colon Cancer: Contouring and treatment planning -- Rectal Cancer: Clinical Data -- Rectal Cancer: Contouring and treatment planning -- Anal Cancer: Clinical Data -- Anal Cancer: Contouring and treatment planning -- Pelvic Recurrences: Clinical Data -- Pelvic Recurrences: Contouring, treatment planning, and Intra-operative Radiation Therapy -- Stereotactic Body Radiation Therapy to the Liver for Metastatic disease: Clinical Data -- Stereotactic Body Radiation Therapy to the Liver for Metastatic disease: Contouring and treatment planning.

This book is a comprehensive guide to the use of modern radiation therapy techniques for prostate cancer and other common and rare genitourinary malignancies. It will be an ideal resource for clinicians and trainees wishing to delve more deeply into the practical and technical aspects of radiotherapy for these malignancies and will serve to enhance day-to-day management in clinical practice. The first section is devoted to prostate cancer and includes coverage of low dose rate and high dose rate brachytherapy, conventionally fractionated, moderately hypofractionated, and ultra-hypofractionated external beam radiotherapy, and proton therapy. The second section focuses on radiotherapy considerations in relation to bladder cancer, testicular cancer, renal cell carcinoma, and rare malignancies such as penile cancer and urethral cancer. Radiotherapeutic treatment of patients with genitourinary malignancies now involves unprecedented precision and complexity, and this book will enable readers to exploit fully the exciting advances that have been achieved in recent years.

Part I: Fundamentals -- Liver Anatomy and Function -- Imaging Characteristics of Normal liver and liver tumors -- Assessment of Liver Function: Focus on the ALBI Score -- Radiation Oncology: Fundamentals and Controversies -- Radiation Sensitivity of the Liver: Models and Clinical Data -- Part II: Principles of Surgery, Intra-arterial Therapies, and Thermal Ablation -- Surgical Considerations -- Principles of Intra-arterial Therapies -- Principles of Thermal Ablation -- Part III: Principles of Radiation Therapy -- External beam radiation therapy for liver tumors: Simulation, Treatment Planning, and Advanced Delivery Techniques -- Particle Radiation Therapy for Liver Tumors: Simulation and Treatment Planning -- Yttrium-90 Selective Internal Radiation Therapy -- Interstitial Brachytherapy For Liver Tumors: Practical Issues -- Part IV: Hepatocellular Carcinoma -- Hepatocellular Carcinoma: Epidemiology, Basic Principles of Treatment, and Clinical Data -- Radiation Therapy for Hepatocellular Carcinoma: Clinical Data -- Part V: Intrahepatic and Hilar Cholangiocarcinoma -- Intrahepatic and Hilar Cholangiocarcinoma: Epidemiology, Basic Principles of Treatment, and Clinical Data -- Radiation Therapy for Intrahepatic and Hilar Cholangiocarcinoma: Clinical Data -- Part VI: Liver Metastases -- Liver Metastases: Basic Principles of Treatment and Clinical Data -- Radiation Therapy for Liver Metastases: Clinical Data -- Part VII: Perspectives on Multidisciplinary Management -- Multidisciplinary Model for Liver Tumors -- Part VIII: Future Directions -- Radiation Therapy for Liver Tumors: Future Directions.

This book provides a state-of-the-art review of the role of radiation therapy in various pelvic malignancies as well as the consequences of the radiation in the pelvic tissues. With sections covering the role of radiation therapy in the various pelvic malignancies, the pathophysiology of radiation related injury and the risk factors that increase the possibility of such an injury, and the latest in medical, endoscopic and surgical therapies for these radiation related complications the text offers a concise yet comprehensive overview of radiation therapy in the human pelvis, its role and the adverse effects on the pelvic organs. Written by experts in the field with readers in mind, Radiation Therapy for Pelvic Malignancy and its Consequences is the first of its kind standalone reference on the subject. ℗ℓ Radiation Therapy for Pelvic Malignancy and its Consequences is of great value to urologists, medical radiation and gynecological oncologists, and gastroenterologists.

This practical guide to the use of radiotherapy for the treatment of sarcomas and skin cancers covers a wide range of disease scenarios, identifying which treatment techniques are applicable in particular clinical circumstances. Among the conditions considered are extremity soft tissue sarcomas, retroperitoneal soft tissue sarcomas, bone sarcomas, uterine sarcomas, chordomas, pediatric sarcomas, squamous cell carcinomas, basal cell carcinomas, melanomas, Merkel cell carcinomas, and cutaneous lymphomas. Detailed attention is devoted to the issues and considerations of relevance in everyday practice when treating these diseases. The use of multiple radiotherapy techniques and procedures, including IMRT, brachytherapy, radiosurgery, and particle therapy, is fully explained, and the role of radiotherapy in combination with chemotherapy and emerging therapeutics such as immunotherapy and biologic anticancer agents is also addressed. The book will be of high value for practicing radiation oncologists, medical and surgical oncologists, medical physicists, medical dosimetrists, trainees, and other medical professionals.

History of radiation therapy in dermatology -- Radiobiology -- Physical aspects of dermatological radiotherapy -- Radiation protection -- Staging of squamous cell carcinoma and basal cell carcinoma -- Acute and chronic cutaneous reactions to radiotherapy -- Efficacy of superficial radiotherapy -- Treatment selection for superficial radiotherapy -- Superficial radiation therapy treatment planning -- Current use of dermatologic radiotherapy in the United States -- Grenz ray therapy -- Radiotherapy for cutaneous squamous and basal cell carcinomas -- Brachytherapy -- Cutaneous merkel cell carcinoma -- Radiotherapy for cutaneous angiosarcoma -- Radiotherapy for dermatofibrosarcoma protuberans -- Squamous and basal cell carcinomas with perineural invasion -- Getting started in superficial radiation for the dermatology practice.

Hodgkin Lymphoma / Stephanie Terezakis, John P. Plastaras, pages 1-28 -- Diffuse Large B-Cell Lymphoma / N. George Mikhaeel, Lena Specht, pages 29-43 -- Follicular Lymphoma: Treatment for Early-Stage, Grades 1 and 2, and Advanced-Stage Disease / Bradford Hoppe, pages 45-53 -- Extranodal Marginal Zone Lymphoma / Umberto Ricardi, Andrea Riccardo Filippi, Cristina Piva, Mario Levis, pages 55-71-- Primary Mediastinal (Thymic) Large B-Cell Lymphoma / Andrea K. Ng, pages 73-83 -- Plasmacytoma and Multiple Myeloma / Richard Tsang, pages 85-96 -- Role of Radiation in the Treatment of Leukemias: Lymphoblastic Lymphoma, Central Nervous System Disease, and Chloromas / Bouthaina Shbib Dabaja, pages 97-114 -- Primary CNS Lymphoma / Chelsea Pinnix, pages 115-127 -- Primary Testicular Lymphoma / Andrew Wirth, Chan Yoon Cheah, pages 129-141 -- Radiation Therapy in the Management of Mantle Cell Lymphoma / Sarah A. Milgrom, pages 143-155 -- Extranodal NK/T-Cell Lymphoma, Nasal Type / Yexiong Li, pages 157-180 -- Radiation Therapy in the Management of Cutaneous T-Cell Lymphomas / Grace L. Smith, pages 181-197.

This book is a comprehensive review and study aid for radiation therapists. Organized in a question-and-answer format, it present clinical features and principles of treatment. Topics include radiation therapy physics, radiobiology, treatment and simulation equipment, principles of patient care, clinical components of cancer care, and cancers of the brain, head and neck region, and respiratory, digestive, urinary, and male and female reproductive systems. It offers over 500 multiple-choice questions with detailed answers and rationales. Radiation Therapy Study Guide is a valuable resource for radiation therapists preparing for certification examinations as well as for practicing therapists in need of a review.

Whole Breast Radiation -- Post-Mastectomy Radiation -- Techniques for Internal Mammary Node Radiation -- Target Delineation and Contouring -- Accelerated Partial Breast Irradiation -- Deep Inspiration Breath Hold -- Intensity-Modulated Radiation Therapy -- Techniques for Proton Radiation -- Hyperthermia in Locally Recurrent Disease.

This book is a practical guide to the use of modern radiation therapy techniques in women with gynecological cancers. Step-by-step instruction is provided on simulation, contouring, and treatment planning and delivery for cancers of the cervix, endometrium, vagina, and vulva. Beyond external beam radiation delivery, full details are presented on three-dimensional brachytherapy at all sites for which it is applicable. Moreover, in-depth guidance is offered on the various advanced techniques of radiation delivery, including intensity-modulated radiation therapy, image guidance for external beam and brachytherapy, and stereotactic body radiotherapy. Radiation therapy is a critical component of the multidisciplinary management of gynecological tumors. With modern technology, both external beam radiation and brachytherapy can be delivered in a highly conformal way. This requires precise contouring and accurate planning techniques. In clearly describing the indications for and the delivery of quality radiation therapy for gynecological tumors, this book will benefit radiation oncologists, medical physicists, medical dosimetrists, radiation therapists, and radiotherapy residents.

In this book, leading experts in the dermatological and oncological field describe the use of radiation therapy for the treatment of the full range of dermatological malignancies ? including basal cell carcinoma, squamous cell carcinoma, cutaneous lymphomas, Kaposi's sarcoma, melanoma, and Merkel cell tumor ? as well as those precancerous lesions and non-malignant dermatological disorders which are amenable to radiation therapy. In each case the specific indications for the use of radiotherapy and its application are clearly explained with the aid of numerous high-quality illustrations. In addition, the book provides a concise introduction to physical and radiobiological principles, selection of radiation factors, dose definitions, radiation reactions, and risk assessments. The new edition has been thoroughly revised and updated to reflect advances in practical knowledge and clinical practice. It will be an invaluable source of information on the management of skin tumors and related non-malignant disorders for both dermatologists, oncologists and radiation oncologists.

History of radical and reconstructive surgery for gynecologic cancer -- Surgical anatomy and instrumentation -- Radical hysterectomy with en bloc vaginectomy and pelvic lymphadenectomy -- Fertility-sparing radical abdominal trachelectomy -- Radical vulvectomy -- Radical cystectomy -- Abdominoperineal excision of the rectum -- Pelvic exenteration -- Laterally extended endopelvic resection -- Bone and extended pelvic resections -- Incontinent urinary diversions -- Continent diversions -- Bladder and ureteral substitution and augmentation -- Colorectal anastomosis, colostomy, and small bowel anastomosis -- The ileal pouch anal anastamosis -- Skin grafts, omental flaps, advancement and rotational flaps -- Rectus abdominis flaps and pudendal thigh and related flaps -- Gracilis, tensor fascia lata, vastus laterlis, rectus femoris, and gluteus maximus flaps -- Tissue rearrangement techniques and regional flaps -- Bioprosthetic and prosthetic materials in abdominal wall reconstruction and hernia repair -- Rehabilitation, quality of life, and symptom management.

Renowned political scientist Terri Givens calls for 'radical empathy' in bridging racial divides to understand the origins of our biases, including internalized oppression. Deftly weaving together her own experiences with the political, she offers practical steps to call out racism and bring about radical social change.

Radical Prostatectomy: Surgical Perspectives provides surgeons with a comprehensive overview of the anatomical approach to radical prostatectomy, whether done through an open (retropubic) or robotic-assisted laparoscopic approach. All chapters are structured to provide a step-by-step approach to the most technically demanding and most common oncologic procedure in urology surgery. The book includes highly practical presentations of typical surgical patients seen in the clinical practice of urology and relies heavily on illustrations and intraoperative photographs to clearly complement the text. In addition, the book ?includes a detailed description of the management of uncommon but potentially serious intraoperative complications, including major vascular injury, ureteral transaction, and rectotomy. Written by authors from a variety of integrated disciplines, including anesthesia, cardiology, and nursing Radical Prostatectomy: Surgical Perspectives is a unique and valuable resource in the field of urology both for those currently in training and for those already in surgical practices.

Maull guides us step-by-step to shift our fear-based conditioning into the habits of courage, compassion, and positive change. With Radical Responsibility, he invites us to experience for ourselves the life-changing journey from victim to co-creator.

"Radical SAM Enzymes, Volume 606, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on the Characterization of the glycyl radical enzyme choline trimethylamine-lyase and its radical S-adenosylmethionine activating enzyme, Diphathimide biosynthesis, Radical SAM glycyl radical activating enzymes, Radical SAM enzyme BioB in the biosynthesis of biotin, Biogenesis of the PQQ cofactor, Role of MoaAC in the biogenesis of the molybdenum cofactor, Biosynthesis of the nitrogenase cofactor, Bioinformatics of the radical SAM superfamily, The involvement of SAM radical enzymes in the biosynthesis of methanogenic coenzymes, methanopterin and coenzyme F420, and more"--Publisher.

[1] Basic physics and instrumentation by E. H. Quimby [and others]--[2] Medicine, by S. S. Silver.

This book presents new information on radiobiology that more clearly refutes the linear no-threshold (LNT) assumption and supports radiation hormesis. Fresh light is cast on the mechanisms of radiation hormesis and the potential benefits of low-dose ionizing radiation in preventing and treating a wide variety of inflammatory and proliferative diseases. It is proposed that these effects may derive from cellular communication via electromagnetic waves directed by DNA, with each cell acting as a quantum computer. Readers will also find close analysis of the negative impacts of radiophobia on many aspects of modern life, including attitudes to imaging technologies, licensing of nuclear power reactors, and preparedness for survival of nuclear war. The book will be of interest to researchers and scientists in radiobiology, radiation protection, health physics, medical physics, and radiology. Specifically, it will provide medical physicians, radiation oncologists, radiation epidemiologists, gerontologists, cell biologists, toxicologists, and nuclear engineers with a wide range of interesting facts and enlightening novel perspectives. -- publisher's website.

Physics and chemistry of radiation absorption -- Molecular mechanisms of DNA and chromosome damage and repair -- Cell survival curves -- Radiosensitivity and cell age in the mitotic cycle -- Fractionated radiation and the dose-rate effect -- Oxygen effect and reoxygenation -- Linear energy transfer and relative biologic effectiveness -- Acute radiation syndrome -- Medical countermeasures to radiation exposure -- Radiation carcinogenesis -- Heritable effects of radiation -- Effects of radiation on the embryo and fetus -- Radiation cataractogenesis -- Radiologic terrorism -- Doses and risks in diagnostic radiology, interventional radiology and cardiology, and nuclear medicine -- Radiation protection -- Molecular techniques in radiobiology -- Cancer biology -- Dose-response relationships for model normal tissues -- Clinical response of normal tissues -- Model tumor systems -- Cell, tissue, and tumor kinetics -- Time, dose, and fractionation in radiotherapy -- Retreatment after radiotherapy: the possibilities and the perils -- Alternative radiation modalities -- The biology and exploitation of tumor hypoxia -- Chemotherapeutic agents from the perspective of the radiation biologist -- Hyperthermia.

Introduction and Background -- The "Radio-resistance" of Glioblastoma in the Clinical Setting, and the Present Therapeutic Options -- Radiobiological Hints from Clinical Studies -- Chemo-radiotherapy: Radiation Total Dose and Fractionation -- Clinical Evidence and Radiobiological Background of Particle Radiation Therapy -- Mathematical Modeling of Radiobiological Parameters from Clinical Studies -- Clinical, Pathology and Molecular Prognostic Parameters of Response to Chemo- and Radiotherapy from Clinical Series -- Radiation Tolerance of Normal Brain: QUANTEC 2010 and Beyond -- Basic Knowledge of Glioblastoma Radiobiology -- Molecular Radiobiology and Mathematical Modeling -- Genetic and Epigenetic Determinants in Tumor Initiation and Progression -- Tumor Microenvironment -- Cell Death Pathways, with Special Regard to Ionizing Radiation and Temozolomide Therapy -- mi-RNA Manipulation in Modifying Radiation Sensitivity in Glioblastoma Models -- Glioma Stem-like Cells and Radiation Resistance -- Hypoxia and Radiation Resistance -- Invasiveness and Radiation Failures -- Nanoparticle Technology for Research Radiobiology -- The Molecular Classification of Glioblastoma as a Translational Instrument -- Translational Perspectives for Gene Therapy -- Pre-Clinical Models of Glioblastoma in Radiobiology: Evolving Protocols and Research Methods -- From Molecular to Clinical Radiation Biology -- Perspectives of the Large Data-Bases and Ontologic Models of Correlation of Pre-clinical and Clinical Results -- Conclusive Remarks and Perspectives for Future Research.

Investigates radiocesium movement in all major components of forest ecosystems, e.g. the plants, animals, insects, microorganisms, and soils, during the initial stage of contamination after the incident at Fukushima Daiichi Nuclear Power Plant. Most of the work was conducted at a common research site. More specifically, the book examines the contribution of surface uptake by trees in the dynamics of radiocesium during the initial contamination stage; the movement of radiocesium in the form of small organic fragments that are essential to the radiocesium dynamics in forest ecosystems; and the upward movement of radiocesium due to microorganism activity, which promotes the effective decontamination of the forest floor. Lastly, it explains why spiders could be a valuable indicator of the contamination level in forest ecosystems.

Diagnosis of small Hepatocellular carcinoma -- Pathobiologic characteristics of small hepatocellular carcinoma -- Radiofrequency ablation systems and operating mechanisms -- Initial Clinical Assessment and Patient Selection -- Percutaneous Radiofrequency Thermal Ablation -- Laparoscopic and Open RFA -- Peri-RFA care and management of complications -- Combined therapies of RFA -- Radiological assessment and follow-up after radiofrequency -- Adjuvant therapy after Radiofrequency Ablation -- Surgery vs Radiofrequecy Ablation for Small Hepatocellular Carcinoma.

Radiofrequency (RF) has been used in many areas of medicine for some time, but only gained popularity in aesthetics in the early 2000s. Although initial procedures provided variable results, the field of RF has grown dramatically. Currently, a multitude of devices which offer an array of technologies, each geared to specific applications, are on the market. In this book, a comprehensive discussion of the evolving area of RF is provided, and the current and cutting-edge technologies which span from noninvasive treatments of facial wrinkles to invasive body contouring procedures are discussed in detail. The methodologies covered include thermal and ablative modalities, volumetric and fractional approaches, as well as practical aspects of application in clinical practice. Included are also pearls on patient management and prevention and treatment of complications. Finally, RF-based procedures are compared with equivalent laser and surgical approaches in a risk-benefit evaluation. Reviewing the standard of care for RF-based treatments and providing information relevant for clinical decision-making and practice management, this publication is a valuable tool for dermatologists, plastic surgeons and all practitioners who use or are contemplating the introduction of RF into practice.

This book describes the principles and applications of radiofrequency treatments for various spinal indications, including disc herniation, discogenic and radicular pain, facet joint arthropathy, and benign and malignant lesions of the vertebral column. The aim is to provide a handy guide that will acquaint readers with all aspects of radiofrequency neurotomy at different levels of the spine, enabling them to carry out treatments effectively and safely. Radiofrequency neurotomy, or radiofrequency ablation, is a minimally invasive procedure that is associated with a reduction in complications, side effects, and risks of anesthesia as well as with lower costs. This book, written by world-renowned authorities in the field, fills a significant gap in the literature by specifically focusing on the use of radiofrequency for spinal conditions. It will be of value to a range of specialists, including interventional neuroradiologists and radiologists, neurosurgeons, and orthopedists.

I. Pulmonary tuberculosis -- II. Non-tuberculous affections.

Part 1 Introduction -- The History of Radioguided Surgery: Early Historical Milestones and the Development of Later Innovative Clinical Applications -- Part 2 Detailed Methodology Part -- Physics of Radioguided Surgery -- The use of intraoperative small and large field of view gamma cameras for radioguided surgery -- Surgical Navigation -- Tracers applied in radioguided surgery -- Radiation Safety and Dosimetry -- Part 3 Clinical Application: Breast -- Radioguided sentinel lymph node mapping and biopsy in breast cancer -- Radioguided Surgery for Non-Palpable Breast Lesions: I-125 Radioactive Seed Localization.- Radioguided Surgery for Non-Palpable Breast Lesions: Technetium-99m Radioguided Occult Lesion Localization (ROLL) -- Part 4 Clinical Application: Skin -- Radioguided sentinel lymph node mapping and biopsy in cutaneous melanoma -- Part 5 Clinical Application: Head and Neck -- Sentinel lymph node mapping and biopsy in oral cancer -- Part 6 Clinical Application: Thyroid and Parathyroid -- Radioguided sentinel lymph node mapping and biopsy in thyroid cancer -- Radioguided Parathyroid Surgery -- Radioguided surgery of thyroid carcinoma recurrences -- Part 7 Clinical Application: Urogenital Tract -- Radioguided sentinel lymph node biopsy and lymphatic mapping in urogenital malignancies -- Radioguided sentinel lymph node mapping and biopsy in Gynaecological malignancies -- Part 8 Clinical Application: Gastrointestinal Tract -- Radioguided sentinel lymph node mapping and biopsy in oesophago-gastric -- Radioguided sentinel lymph node mapping and biopsy in colorectal cancer -- Radioguided surgery in gastro-entero-pancreatic neuroendocrine tumors -- Part 9 Clinical Application: Thoracic -- Radioguided sentinel lymph node mapping and biopsy in non-small-cell lung cancer (NSCLC) -- Radioguided surgery of small pulmonary nodules -- Part 10 Miscellaneous -- Radioguided localization of bone lesions -- Radioguided monitoring of systemic leakage during isolated limb perfusion -- Radioimmunoguided Surgery: Intraoperative radioimmunodetection for the radioguided localization and resection of tumors -- 18F-FDG-Directed Surgery and 18F-FDG-Directed Interventional Procedures -- Part 11 Outlook: New techniques, image fusion, optical imaging -- Fluorescent tracers, hybrid tracers -- Magnetic Advances in Cancer Surgery -- Ultrasound fusion -- Part 12 Examples (conventional techniques and innovations). .

pt. 1. Theory -- pt. 2. Experiments -- pt. 3. Neutron Experiments.

"High-yield, image-rich study guide presents complex physics concepts in reader-friendly format Physics is a key component of the American Board of Radiology core and certifying exams, therefore it is an essential area of study for radiology residents and young radiologists prepping for these exams. Radiology residents gather their medical physics knowledge from many sources, often beginning with their first encounter of a radiologic image. As such, Radiologic Physics Taught Through Cases by Jonathon A. Nye and esteemed contributors incorporates an image-rich, case-based layout conducive to learning challenging physics concepts. The book encompasses physical diagnostic radiology scenarios commonly encountered during residency in a format that fosters learning and is perfect for board preparation. Seven technology-specific chapters cover fluoroscopy, mammography, computed tomography, magnetic resonance imaging, nuclear medicine, ultrasound imaging, and image processing. Each chapter features 10 succinct case-based topics intended to quickly convey information. Key Highlights: Every chapter starts with a general introduction, followed by case background, images, findings, and a brief explanation of the physical factors underlying the image's creation and displayed contrast Schematics detail important radiation safety topics, such as potential occupational or patient hazards related to fluoroscopic-guided procedures End-of-chapter references provide inspiration for further study. Review questions with correct answers at the end of each chapter reinforce key concepts This is a must-have resource for residents prepping for the radiology core exam review and early-career radiologists looking for a robust study guide for radiology certification exam review"-- Provided by publisher.

v. 1. 1500 Multiple choice questions and referenced, selected explanatory answers; plus pretest and post-test examinations.

Three years after the publication of the first edition, Radiological Anatomy for FRCR Part 1 remains the best seller in its category based on its faithful representation of the examination. This second edition is designed to reflect the change in exam format introduced in spring 2013. It includes two new chapters as well as some new cases in the remaining chapters and tests. Under the new exam format, candidates will be presented with 100 cases, with a single question per case and a single mark for the correct answer. This book covers all core topics addressed by the exam in a series of tests and includes chapters focussing specifically on paediatric cases and normal anatomical variants. The answers to questions, along with explanations and tips, are supplied at the end of each chapter. Care has been taken throughout to simulate the exam itself. The book aims not to replace the already available literature on radiological anatomy but rather to complement it as a revision guide. It will help candidates to identify the level of anatomical knowledge expected by the Royal College of Radiologists.

This book, now in its second edition, provides a comprehensive analysis of imaging of the kidneys, upper urinary tract, and ureters, covering the normal anatomy and anatomic variants as well as all renal and urinary system pathologies. The relevant imaging modalities are first discussed, with detailed description of their applications in the kidney and upper urinary tract. The entire spectrum of kidney pathologies is then presented in a series of detailed chapters with up-to-date references, high-quality images, informative schemes, and figures showing macroscopic and microscopic surgical and pathologic specimens. Chapters relating to the latest innovations in tumor ablation, vascular and nonvascular interventional procedures, and parametric and molecular imaging have been fully updated to reflect progress in these rapidly evolving fields. This book will be of great interest to all radiologists, oncologists, nephrologists, and urologists who are involved in the management of kidney pathologies in their daily clinical practice.

This book provides a state-of-the-art review of the technical and clinical aspects of the vascular interventional radiological (IR) procedures currently employed in obstetrics and gynaecology. A particular focus is on uterine artery embolisation for fibroid disease, which is contrasted with the main alternative uterus-conserving surgical approach of myomectomy, and with ablation therapy. Detailed consideration is also given to the role of embolisation in a variety of other less common conditions, including arteriovenous malformations, post-partum haemorrhage, abnormal placentation and pelvic congestion syndrome. IR procedures are examined from a critical gynaecological perspective and with regard to surgical alternatives. The authors include leading interventional radiologists and gynaecologists from the United Kingdom, Europe and North America. .

Radiological Safety and Quality - Paradigms in Leadership and Innovation is a multi-disciplinary and inter-sectorial collaboration by international experts and leaders from academic institutions, radiology practices, professional organizations, regulatory authorities, UN and international agencies. Established principles and new concepts, challenges and opportunities, and examples of leadership and innovations are discussed to raise awareness, share experience and facilitate development of facility-based or system-wide improvements in radiation safety, quality radiology, and patient care by procedure justification, optimization of protection and imaging data, and incident minimization. The 26 chapters by 53 experts and 11 messages from international organizations and agencies convey a common theme: there is no single panacea to improve radiological safety and quality but on-going leadership, innovation, collaboration, and stakeholder participation are needed.

Introduction -- Introduction / Antonio Zicca, Alberto Tagliafico -- Upper limb -- Shoulder / Erica Fisci, Alberto Tagliafico -- Elbow / Alberto Tagliafico, Carlo Martinoli -- Wrist / Alberto Tagliafico, Carlo Martinoli -- Lower limb -- Hip / Alberto Tagliafico, Erica Fisci, Carlo Martinoli -- Knee / Alberto Tagliafico, Carlo Martinoli -- Ankle / Bianca Bignotti, Carlo Martinoli, Alberto Tagliafico -- Spine -- Spine / Erica Fisci, Alberto Tagliafico

1. Introduction -- 2. Diagnostic Imaging -- 3. Radiation Safety -- 4. X-rays and X-ray Tubes -- 5. Ultrasound -- 6. CT -- 7. MRI -- 8. Nuclear Medicine -- 9. Contrast Materials -- 10. Chest Overview -- 11. Cardiac -- 12. Abdomen -- 13. Acute Abdomen -- 14. Gastrointestinal Tract -- 15. Hepatobiliary System -- 16. Pancreas -- 17. Urinary Tract -- 18. Staging Cancer -- 19. Musculoskeletal -- 20. Severe Trauma Basics -- 21. Mammography -- 22. Interventional -- 23. Neuroradiology -- 24. Acute Care Chest -- 25. Midterm Quiz.

1. Subtotal nephrectomy and tumour ablation -- 2. Renal transplantation -- 3. Imaging after endo-urological stone treatment -- 4. Pelvi-ureteric junction reconstruction -- 5. Retroperitoneal fibrosis -- 6. Urinary diversion -- 7. Ureteric reconstruction and replacement -- 8. Conservative and reconstructive bladder surgery -- 9. Bladder augmentation in children -- 10. Radiology and follow-up of the neobladder -- 11. General consequences of lower urinary tract replacement and reconstruction -- 12. Surgery on the benign prostate -- 13. Imaging after treatment of prostate cancer -- 14. Urethroplasty -- 15. The postoperative appearance and follow-up of urinary tract prostheses -- Index.

Reading PET/CT scans is sometimes challenging. Not infrequently, abnormal findings on CT images are functionally silent and therefore difficult for nuclear medicine practitioners to interpret. Furthermore, in general only a low-dose CT scan is produced as part of the combined PET/CT study, and the resulting CT images may prove suboptimal for image interpretation. This atlas is designed to enable nuclear medicine practitioners who routinely read PET/CT scans to recognize the most common CT abnormalities. Slice-by-slice descriptions are provided of anatomical structures as visualized on CT scans obtained in PET/CT studies. The CT findings that may be detected while reviewing PET/CT scans of various body regions and conditions are then illustrated and fully described. The concluding section of the book is devoted to the principal MRI findings in diseases which cannot be evaluated using PETs/CTs.

This atlas is intended to enable nuclear medicine practitioners who routinely read PET/CT scans to recognize the most common CT abnormalities. Reading PET/CT scans can sometimes be challenging. It is not infrequent, in fact, to encounter abnormal findings in CT images (not related to the neoplastic disease under evaluation) that are functionally silent and therefore difficult to interpret for nuclear medicine practitioners. Frequently, these findings are clinically relevant and should be reported, interpreted and compared to previous scans. This may also have an impact on patient management, since expensive tests like PET/CT are expected to provide the highest level of diagnostic information. Generally, CT images associated with a PET scan are acquired in a low-dose modality, and therefore prove to be sub-optimal for CT image interpretation. Sometimes a comparison with a full-resolution and contrast-enhanced CT atlas may be difficult. Low-dose CT slices are thicker than diagnostic CT and offer less anatomical detail, which can affect accuracy in terms of recognizing both anatomical structures and pathological findings. Today it is becoming increasingly common to acquire a standard PET/CT by combining the administration of contrast media and a diagnostic CT; here, too, basic CT reporting skills are needed in clinical practice. This atlas features a chapter on "normal anatomy" (with and without contrast media) that is based on low-dose and full-dose CT images from PET/CT standard acquisition, and which identifies all the relevant anatomical structures. Other chapters (focusing on the thorax, abdomen, pelvis, and musculoskeletal system) present cases with common and uncommon anatomical abnormalities. The addition of new cases with ceCT in this revised second edition rounds out the coverage of PET/CT reporting. Given its scope, the book will be of interest to nuclear medicine physicians, radiologists, and oncologists alike.

This book is a concise introduction to the dynamic field of radiology and provides readers with general examples and brief discussions of basic radiographic principles. Introductory chapters present fundamental scientific concepts underlying the medical use of imaging modalities and technology, including ultrasound, computed tomography, magnetic resonance imaging, and nuclear medicine. Subsequent chapters are organized by anatomic region and imaging modality that highlight the radiologist?s role in diagnosing and treating common disorders. This revised edition is thoroughly updated and includes new or expanded chapters on nuclear medicine and pediatric radiology. Radiology Fundamentals, Fifth Edition, is a premier self-directed learning resource for medical students, non-radiology housestaff, physician assistants, nurse practitioners, radiologist assistants and other allied health professionals.

This book serves as an introduction to the dynamic field of radiology for medical students, non-radiology house staff, physician assistants, nurse practitioners, radiology assistants, and other allied health professionals and provides information that ranges from basic radiographic principles to advanced imaging techniques. It begins with a discussion of the fundamental concepts underlying the medical use of imaging modalities such as ultrasound, computed tomography, magnetic resonance imaging, and nuclear medicine. Subsequent chapters are organized by anatomic region and imaging modality that highlight the radiologists role in diagnosing and treating common disorders. Each chapter offers learning objectives to aid readers in recognizing important points and connecting the basic radiology concepts. The sixth edition is thoroughly updated. The editors and authors introduce the approach to SAFE radiology, explaining the concepts of S-safety in all modalities, A-appropriateness of imaging ordering, F-interpreting films and E-acting expeditiously on significant findings and executing the recommendation of the imaging findings. Easy to learn and easy to remember, SAFE reminds all health care professionals that safety and appropriateness should precede any imaging testing and that all results should be applied expeditiously and thoughtfully.

The nutcracker phenomenon (NCP) is an accentuated phenomenon of normal subtle compression of the left renal vein (LRV) between the abdominal aorta and superior mesenteric artery. The nutcracker syndrome (NCS) is a syndrome caused by NCP, resulting in hematuria, proteinuria, or left flank pain. The established diagnostic criterion of NCP is a pressure gradient more than 3 mmHG across the compression site, and NCS has been known to be rare, but probably is not rare and in fact quite common. The most important reason why NCS is known to be rare is that the diagnosis is difficult unless invasive venous catheterization and pressure measurement confirm the pressure gradient. Doppler ultrasound is useful in measuring the flow velocity of LRV. From the velocity measured by Doppler ultrasound, we may estimate the pressure gradient. Doppler ultrasound of LRV needs technical skills and experience. Computed tomography (CT) is a popular imaging technique for patients with hematuria, and we need to be familiar with the findings of the NCP at CT. There are variations of NCP associated with vascular anatomy and posture of the patients. This book will illustrate the concepts of NCP and NCS, findings at Doppler ultrasound and CT, and variations of NCP.

Illustrates how to achieve reliable diagnoses when confronted by the different abnormalities, or disease patterns, that may be visualized on CT scans of the chest.

Part 1. Pharynx/Esophagus -- 1. Benign structural and functional abnormality of the esophagus, postop. Complication of the esophagus -- 2. Esophagitis -- 3. Benign and malignant tumor of the esophagus -- Part 2. Stomach/Duodenum -- 4. Benign structural & functional abnormality of the stomach and duodenum -- 5. Inflammatory and infectious diseases of the stomach and duodenum -- 6. Mucosal tumor of the stomach -- 7. Subepithelial tumor of the stomach -- 8. Lymphoma and metastasis of the stomach -- 9. Postoperative change and complications of the stomach and duodenum -- Part 3. Small Bowel -- 10. Benign structural & functional abnormality of the small bowel -- 11. Inflammatory disease of the small bowel -- 12. Vasculitis and ischemic bowel disease -- 13. Small bowel obstruction -- 14. Benign tumor of the small bowel -- 15. Malignant tumor of the small bowel -- Part 4. Colon -- 16. Benign structural & functional abnormality of the colon -- 17. Inflammatory & infectious disease of the colon -- 18. Benign tumor of the colon -- 19. Malignant tumor of the colon -- 20. Postoperative change and complications of the colon -- Part 5. Mesentery, Peritoneum, abdominal wall -- 21. Benign diseases of mesentery and omentum -- 22. Malignant diseases of mesentery and omentum -- 23. Abdominal wall abnormality & hernia.

Radiology Illustrated: Hepatobiliary and Pancreatic Radiology is the first of two volumes that will serve as a clear, practical guide to the diagnostic imaging of abdominal diseases. This volume, devoted to diseases of the liver, biliary tree, gallbladder, pancreas, and spleen, covers congenital disorders, vascular diseases, benign and malignant tumors, and infectious conditions. Liver transplantation, evaluation of the therapeutic response of hepatocellular carcinoma, trauma, and post-treatment complications are also addressed. The book presents approximately 560 cases with more than 2100 carefully selected and categorized illustrations, along with key text messages and tables, that will allow the reader easily to recall the relevant images as an aid to differential diagnosis. At the end of each text message, key points are summarized to facilitate rapid review and learning. In addition, brief descriptions of each clinical problem are provided, followed by both common and uncommon case studies that illustrate the role of different imaging modalities, such as ultrasound, radiography, CT, and MRI.

This case-based atlas presents images depicting the findings typically observed when imaging a variety of common and uncommon diseases in the pediatric age group. The cases are organized according to anatomic region, covering disorders of the brain, spinal cord, head and neck, chest, cardiovascular system, gastrointestinal system, genitourinary system, and musculoskeletal system. Cases are presented in a form resembling teaching files, and the images are accompanied by concise informative text. The goal is to provide a diagnostic reference suitable for use in daily routine by both practicing radiologists and radiology residents or fellows. The atlas will also serve as a teaching aide and a study resource, and will offer pediatricians and surgeons guidance on the clinical applications of pediatric imaging.

Radiology Illustrated: Spine is an up-to-date, superbly illustrated reference in the style of a teaching file that has been designed specifically to be of value in clinical practice. Common, critical, and rare but distinctive spinal disorders are described succinctly with the aid of images highlighting important features and informative schematic illustrations. The first part of the book, on common spinal disorders, is for radiology residents and other clinicians who are embarking on the interpretation of spinal images. A range of key disorders are then presented, including infectious spondylitis, cervical trauma, spinal cord disorders, spinal tumors, congenital disorders, uncommon degenerative disorders, inflammatory arthritides, and vascular malformations. The third part is devoted to rare but clinically significant spinal disorders with characteristic imaging features, and the book closes by presenting practical tips that will assist in the interpretation of confusing cases.

"The only book of its kind to prepare radiology residents interested in working on global health service projects in the developing world Includes information on designing, testing, and deploying clinical strategies adapted for regions with limited resources Presents information technology models to support digital imaging in the developing world This book is designed to increase awareness of the global health problem of lack of access to medical imaging services and presents solutions to overcome disparities in the delivery of radiologic services to the developing world. Featuring an interdisciplinary framework, it discusses economic strategies for sustainable radiology; public health radiology for population-based approaches; clinical model formulation tailored to needs and resources of regions and communities; technology innovation and optimization; and public policy for healthcare system development at the government and international institutional level. It explores the role of radiology in addressing health care disparities and highlights strategies for radiology services planning and implementation in low resource settings. It also provides an overview of the clinical role of medical imaging in the developing world, including epidemiology, disaster response, and specific clinical applications for recognizing and managing illnesses unique to the developing world. Radiology in Global Health: Strategies, Implementation, and Applications examines ways to achieve sustainable long-term imaging strategies for limited resource regions and is a valuable resource for radiologists, radiology residents, radiology technologists, physicians, nurses, and healthcare administrators"--Provided by publisher.

History and current status of quality improvement in radiology -- Key concepts in quality improvement -- Quality improvement : definition and limitations -- Quality improvement tools -- Patient safety -- Quality improvement in radiology -- Radiology-related quality programs and organizations -- Highly reliable organizations/systems in healthcare and radiology -- Future of quality assurance -- Evidence-based imaging -- Patient-centered radiology -- Professionalism and ethics -- Communication -- Error in radiology -- Error management and reduction -- Accounting in radiology -- Radiology informatics -- Statistical tools and quantitative reasoning -- Imaging of pregnant and lactating women -- Safe use of contrast media -- Noninterpretive skills in ultrasound -- Noninterpretive skills in magnetic resonance imaging -- Optimizing radiation dose for computed tomography -- Interventional radiology -- Quality considerations in children -- Emergency radiology -- Malpractice and radiology : a hapless relationship -- Leadership : a manifesto for the nonclinical education of radiologists looking to succeed in difficult times -- Imaging appropriateness guidelines and clinical decision support.

Molecular Biology of HIV/AIDS and Its Clinical Management -- An Overview of Clinical Immunology of HIV/AIDS -- An Overview of Clinical Microbiology of HIV/AIDS -- Epidemiological Investigation of AIDS -- Pathogenetic and Pathological Mechanism -- Clinical Manifestations of HIV/AIDS Infection -- Laboratory Test and Special Examinations -- Diagnostic Imaging -- AIDS Imaging and Evidence Based Medicine -- Clinical Medication Against HIV/AIDS -- Introduction to Assessment and Monitoring of Critical AIDS -- HIV Related Effect Factors -- HIV/AIDS Related Nervous System Diseases -- HIV/AIDS Related Myeleterosisand Peripheral Neuropathy -- HIV/AIDS Related Eye Diseases -- HIV/AIDS Related Neck Diseases -- HIV/AIDS Related Respiratory Diseases -- HIV/AIDS Related Cardiac Diseases -- HIV/AIDS Related Gastrointestinal Diseases -- HIV/AIDS Related Hepatobiliary, Pancreatic and Splenic Diseases -- HIV/AIDS Related Peritoneal and Retroperitoneal Disease -- HIV/AIDS Related Urogenital Disease -- HIV/AIDS Related Musculoskeletal Diseases -- HIV/AIDS Related Pediatric Diseases -- HIV/AIDS Related Skin Diseases -- Functional Imaging of HIV/AIDS.

This book provides a comprehensive overview of state-of-the-art imaging in infectious and inflammatory diseases in head and neck. It starts with a brief introduction of infectious diseases in head and neck, including normal anatomy, classification, and laboratory diagnostic methods. In separate parts of eye, ear, nose, pharynx, larynx, and maxillofacial region, the common imaging techniques and imaging anatomy is firstly introduced, and then typical infectious and inflammatory diseases is presented with clinical cases. Each disease is clearly illustrated with PET and MR images and key diagnostic points. The book provides a valuable reference source for radiologists and doctors working in the area of infectious and inflammatory diseases.

This book offers a systematic coverage of diagnostic imaging in infectious and inflammatory diseases in musculoskeletal system. The first part is devoted to a general review of infectious diseases in musculoskeletal system, as well as pathogenic classification, imaging techniques, pathogenic and imaging characteristics. In the following parts, imaging interpretation of typical infectious and inflammatory diseases affecting bone, joint, and soft tissue is described. Each disease is clearly illustrated using cases combined with high-resolution CT, MRI and PET. The book provides a valuable reference source for radiologists and doctors working in the area of infectious and inflammatory diseases.

Overview of Influenza -- Etiology of Influenza -- Epidemiology of Influenza -- Pathomechanism of Influenza -- Complications of Influenza -- Radiological Modality -- Laboratory Test -- Influenza -- Type A H1N1 Influenza -- Human Infected H5N1 Avian Influenza -- Human Infected H7N9 Avian Influenza -- Human Infected H10N8 Avian Influenza.

A novel strain of influenza A (H1N1) virus emerged and an outbreak of influenza A (H1N1) occurred worldwide in 2009 and 2010, posing a severe threat to the health of human beings. The two Editors work together in Beijing You An Hospital, to combat this type of influenza. This book, Radiology of Influenza A (H1N1), is intended to provide first-hand clinical data and its scientific analysis, thus supporting sound clinical practice for influenza A (H1N1) prevention and treatment as well as related scientific research. The authors have collected over 100 critical influenza A (H1N1) virus-infected cases. For cases of influenza A (H1N1) that resulted in death, autopsies were performed for 8 cases after receiving their families' informed consent. Over 200 reports on pathological and histological analysis as well as immunohistochemical and electroscopic analysis were brought together. This book was then compiled by comparing the published data with the present first-hand data. This book includes a wealth of content, including DR, CT and MRI images, pathological and histological figures, and immunohistochemical and electroscopic figures. Related research, clinical and educational needs can be readily satisfied by its detailed data, texts and figures, as well as typical case reports. Li Hongjun, is professor and director of the diagnostic radiology department in Beijing You An Hospital, affiliated with Capital Medical University, Beijing, China. Li Ning, is professor and president of Beijing You An Hospital, affiliated with Capital Medical University, Beijing, China.

This book provides richly illustrated guidance on the ever-expanding range of implants used in orthopedic surgery. The performance of these implants is assessed on radiographs, but information is not easily available and interpretation of these radiographs is difficult. Covering and illustrating implants from the neck to the foot, readers will understand the different features, what is most critical, and how to determine the overall performance. This book offers guidance for trainees, practising orthopedic surgeons, and radiologists in assessing the radiologic appearance of implants and their potential for future performance.

General introduction to parasitic diseases -- Etiology of parasitic diseases -- Pathophysiology of parasitic diseases -- Pathomechanism of parasitic diseases -- Radiological modalities -- Laboratory diagnosis -- Protozoiasis -- Helminthiasis -- Nematodiasis -- Fluke disease.

Chapter 1. Perfect pictures, imperfect prose -- Chapter 2. Expressing an imaging observation -- Chapter 3. Radiology reporting best practices -- Chapter 4. A guide to reporting style -- Chapter 5. Mastering speech recognition -- Chapter 6. Organizing the radiology report -- Chapter 7. The history of radiology reporting -- Chapter 8. Toward structured reporting -- Chapter 9. Standard terminology for the radiology report -- Chapter 10. How to think about imaging information -- Chapter 11. Decision making for diagnostic imaging -- Chapter 12. The future of radiology reporting -- References -- Index -- Disclosures -- Acknowlegments.

Chapter 1. Perfect pictures, imperfect prose -- Chapter 2. Expressing an imaging observation -- Chapter 3. Radiology reporting best practices -- Chapter 4. A guide to reporting style -- Chapter 5. Mastering speech recognition -- Chapter 6. Organizing the radiology report -- Chapter 7. The history of radiology reporting -- Chapter 8. Toward structured reporting -- Chapter 9. Standard terminology for the radiology report -- Chapter 10. How to think about imaging information -- Chapter 11. Decision making for diagnostic imaging -- Chapter 12. The future of radiology reporting -- References -- Index -- Disclosures -- Acknowlegments.

Introduction to radiography, fluoroscopy, and tomosynthesis -- Introduction to ultrasonography, CT, and MRI -- Introduction to nuclear medicine and molecular imaging -- Introduction to image processing, visualization, and analysis -- Computers in radiology -- Introduction to contrast agents -- Radiation dose and safety considerations in imaging -- Screening mammography -- Diagnostic mammography -- Breast ultrasonography (us) and breast procedures -- Breast MRI -- Cardiac and pericardiac imaging -- Aortic imaging -- Coronary arterial imaging -- Pulmonary vascular imaging -- CT angiography and MR angiography of the peripheral and visceral vasculature -- Imaging of lung nodules and masses -- Imaging of airspace lung disease -- Radiography of interstitial lung disease -- Imaging of mediastinal disease -- Imaging of pleural disease -- Tubes, lines, catheters, and other devices -- Abdominal radiography -- Fluoroscopy of the upper gastrointestinal tract -- CT and MRI of the upper gastrointestinal tract -- Fluoroscopy of the lower gastrointestinal tract -- CT and MRI of the lower gastrointestinal tract -- CT and MRI of the liver, gallbladder, and biliary tract -- CT and MRI of the spleen -- CT and MRI of the pancreas -- CT and MRI of the peritoneum, omentum, and mesentery -- CT and MRI of the acute abdomen and pelvis -- Urography -- Genitourinary tract fluoroscopy -- CT and MRI of the kidney -- CT and MRI of the adrenal glands -- CT and MRI of the retroperitoneum -- Imaging of the female pelvis -- Imaging of the male pelvis -- Brain imaging : anatomy, trauma, and tumors -- Brain imaging : inflammatory, infectious, and vascular diseases -- Advanced neurospinal imaging -- Head and neck imaging, part 1 -- Head and neck imaging, part 2 -- Imaging of extremity trauma -- Imaging of spinal trauma -- Imaging of nontraumatic spinal disorders -- Imaging of metabolic bone disease -- Imaging of arthritis -- Imaging of musculoskeletal infection -- Imaging of musculoskeletal tumors -- MRI of the shoulder -- MRI of the elbow -- MRI of the hand and wrist -- MRI of the hip -- MRI of the knee -- MRI of the foot and ankle -- Obstetric ultrasonography in the first trimester -- Obstetric ultrasonography in the second trimester -- Advanced fetal ultrasonography and therapy -- Neck ultrasonography -- Abdominal ultrasonography -- Musculoskeletal ultrasonography -- Vascular ultrasonography -- Patient sedation and pain management -- Equipment, terms, and techniques in interventional radiology -- Inferior vena cava filters -- Image-guided percutaneous needle biopsy -- Advanced procedures in interventional radiology -- Peripheral arterial disease diagnosis and intervention -- Embolization techniques and applications -- Biliary and portal venous interventions -- Genitourinary and gastrointestinal interventional radiology -- Neurointerventional radiology -- Musculoskeletal interventional radiology -- Pet of oncological disorders -- Pet of nononcological disorders -- Bone scintigraphy -- Pulmonary scintigraphy -- Thyroid, parathyroid, and salivary gland scintigraphy -- Gastrointestinal and genitourinary scintigraphy -- Cardiac scintigraphy -- Brain scintigraphy -- Radiopharmaceutical therapeutic intervention -- Pediatric thoracic radiology -- Pediatric cardiovascular radiology -- Pediatric gastrointestinal radiology -- Pediatric genitourinary radiology -- Pediatric neuroradiology -- Pediatric musculoskeletal radiology -- Imaging of child abuse -- Training pathways in diagnostic imaging -- Medicolegal issues in diagnostic imaging -- Radiology and other imaging-related organizations.

This atlas fills a gap in the literature by documenting in detail the role of nuclear medicine imaging of infection and inflammation. The pathophysiologic and molecular mechanisms on which radionuclide imaging of infection/inflammation is based are clearly explained, but the prime focus of the book is on the clinical relevance of such procedures. Their impact is demonstrated by a collection of richly illustrated teaching cases that describe the most commonly observed scintigraphic patterns, as well as anatomic variants and technical pitfalls. Due attention is paid to the application of recently developed techniques, including multimodality fusion imaging such as SPECT/CT and PET/CT. Emphasis is placed in particular on the ability of multimodality imaging to increase both the sensitivity and the specificity of radionuclide imaging. This atlas will be an excellent learning tool for residents in nuclear medicine and illuminating for other specialists with an interest in the field. Learning tool especially useful for residents in nuclear medicine and for specialists in nuclear medicine approaching the field. Useful integration for residents and for specialists also in infectious and autoimmune diseases, as well as in orthopedics.

This atlas explores the latest advances in radionuclide imaging in the field of inflammatory diseases and infections, which now typically includes multimodality fusion imaging (e.g. in SPECT/CT and in PET/CT). In addition to describing the pathophysiologic and molecular mechanisms on which the radionuclide imaging of infection/inflammation is based, the clinical relevance and impact of such procedures are demonstrated in a collection of richly illustrated teaching cases, which describe the most commonly observed scintigraphic patterns, as well as anatomic variants and technical pitfalls. Special emphasis is placed on using tomographic multimodality imaging to increase both the sensitivity and specificity of radionuclide imaging. The aim of the second edition of this book is to update the first (published in 2013) by reflecting the changes in this rapidly evolving field. Particular attention is paid to the latest advances in the radionuclide imaging of infection and inflammation, including the expanding role of hybrid imaging with [18F]FDG PET/CT SPECT/CT, without neglecting new radiotracers proposed for the imaging of infection/inflammation. Written by respected experts in the field, the book will be an invaluable tool for residents in nuclear medicine, as well as for other specialists.

This atlas, compiled by experienced specialists in the field, is designed as a ready reference on the use of parathyroid scintigraphy in patients with hyperparathyroidism, both for the localisation of parathyroid pathology and as an aid to surgery. The introductory chapters review the basic core knowledge on the subject. Eighty case reviews are then presented, covering gamma camera planar imaging, SPECT, hybrid SPECT-CT, and also PET-CT. In total, 240 illustrations are included, comprising 160 grey-scale photos depicting nuclear medicine and CT images and 80 dual-modality fusion colour photos. This compilation of illustrative clinical cases will greatly assist clinicians and imaging specialists in image interpretation in different settings. The images replicate normal conventional formats used for routine reporting and hence facilitate fast and reliable diagnosis. Each of the case reviews includes documentation of the procedure, findings, and conclusions with relevant commentary. Surgeons, nuclear medicine physicians, and radiologists will find the Radionuclide Parathyroid Imaging: Book and Atlas to be a valuable practical tool and learning aid.

The main purpose of this book is to create a reference for the indications, contraindications, patient selection, treatment practice, treatment side effect management, and follow-up of radionuclide treatments. Besides standard methods such as surgery, chemotherapy, radiotherapy, and hormone therapy, newly developed biological treatments, targeted treatments, personalized treatments, external beam radiotherapy, and targeted radionuclide treatments have begun to take their place in professional practice. Nuclear medicine, in addition to its role as a tracer of cancer, also assumes the role of treating with radioactive molecules directed to the cancer it traces. These traceable next-generation radionuclide treatments, whose efficacy and reliability have been proven and where diagnosis, treatment, and follow-up are carried out together, are increasingly included in oncology practice together with the new developed radiopharmaceuticals, ensuring a high rate of damage to cancer cells while protecting the surrounding normal tissues. Molecular cancer treatment will become more effective with individualized next-generation traceable radionuclide treatments, which will be shaped by genetic studies in the future. Radionuclide treatments for many cancer types and benign diseases are presented by experienced nuclear medicine experts in the light of their own experience and case studies, while systemic treatments in common cancer types and side effect management of these treatments are summarized by medical oncologists. This book will be of interest to nuclear medicine physicians as well as oncologists.

This book provides detailed information on therapeutic radiopharmaceuticals and discusses emerging technologies which have potential for broad clinical implementation. Recent advances in molecular biology, radiopharmaceutical chemistry and radioisotope production have stimulated a new era for the use of radiopharmaceuticals for targeted radionuclide therapy (TRT). Emerging clinical trials include use of peptides and monoclonal antibodies radiolabeled with therapeutic radionuclides for cancer therapy. In addition, small molecules are used for the treatment of chronic diseases such as metastatic bone pain palliation and radiation synovectomy of inflammatory joints. In the interventional arena, therapy of primary and metastatic liver cancer and arterial restenosis following angioplasty of both the coronary and peripheral arteries are being explored. Reactor and accelerator production of therapeutic radioisotopes is also integrated into these discussions. The development and use of radiopharmaceutical targeting characteristics required for treatment of specific disease processes and how these are implemented for radiopharmaceutical design strategies are also described. Radiopharmaceuticals for Therapy will benefit audiences in nuclear medicine and radionuclide therapy and will thus prove an invaluable source of up-to-date information for students, radiopharmaceutical scientists and professionals working in the radiopharmacy and nuclear medicine specialties.

This book reviews the current clinical practice of leptomeningeal metastasis (LM) diagnosis and treatment, which is predominately by intrathecal chemotherapy and/or in combination with external beam radiotherapy. LM is a refractory lethal complication of many human malignancies when neoplastic cells grow in the meninges. The use of penetrating emissions from radionuclides has the advantages of visualizing cerebrospinal fluid (CSF) flow and ablating meninges at shallow depths and has been used to diagnose CSF flow anomalies and to treat LM. The scientific bases of using radionuclides inside human CSF and ablating LM will be discussed within the text, with results from established and completed clinical trials to explore optimal use of radionuclides to diagnose and treat LM. Many limitations of current practices of treating LM are also discussed, as well as potential avenues of overcoming these limitations. This book is an ideal guide for clinical researchers in the practice of treating leptomeningeal metastasis including radiologists, neurologists, oncologists and radiotherapists as well as their associates.

Overview of recent advances -- Modes of therapy -- Practical aspects of external beam therapy -- Practical aspects of endocavitary beam therapy, intraoperative radiation and brachytherapy -- Patient care before, during, and after radiotherapy -- Target delineation, normal tissue contouring, and normal tissue constraints -- Oral cavity -- Nasopharynx -- Oropharynx -- Larync -- Hypopharynx -- Nasal cavity -- Paranasal sinuses -- Salivary glands -- Thyroid -- Skin -- Neck node metastasis from unknown primary -- Treatment of locoregional recurrence.

Imaging, delineation and immobilization: MRI and MR-spectroscopy -- PET imaging in prostate cancer -- Phase contrast X-ray imaging- next generation CT imaging -- Organ contouring for IMRT -- General aspects of patient immobilization -- Internal immobilization: From rectal balloon to hyaluronic acid -- Clinical endpoints: Biochemical recurrence? a valuable endpoint? -- Overall and disease-free survival ? too long to wait? -- Late toxicity ? current scoring concepts -- Quality of life: Assessment and Correlates -- Dose escalation and new radiation techniques: Dose escalation ? an update on randomized clinical trials -- IMRT for prostate cancer -- IGRT- how and when -- Tracking in prostate cancer -- Locally advanced disease: Techniques of pelvic lymphatic irradiation -- Prophylactic treatment of the pelvic lymphatics: pro -- Prophylactic treatment of the pelvic lymphatics: contra -- Hormonal therapy and radiation therapy -- randomized and prospective trials -- Treatment of clinically involved lymph nodes -- Hypofractionation: Hypofractionation in prostate cancer- biological aspects -- Hypofractionation: Clinical data -- Simultaneous integrated boost techniques -- Brachytherapy: Principals of 3D, highly conformal brachytherapy -- Seed implantation -- HDR brachytherapy -- Adjuvant treatment and salvage treatment: Target volume definition in postoperative radiotherapy -- Randomized trials for adjuvant radiotherapy -- Salvage radiotherapy after radical prostatectomy -- Salvage prostatectomy after radiotherapy -- Use of protons and heavy ions: Proton therapy for prostate cancer: technological and clinical aspects -- There is evidence for the superiority of protons or heavy ions, pro -- There is evidence for the superiority of protons or heavy ions, contra. .

This book provides up-to-date information on all aspects of radiotherapy for liver cancer, from the basic science to clinical practice. While demand for radiotherapy of liver cancer has been increasing, the guidance available to clinicians has remained limited. Radiotherapy of Liver Cancer aims to address this deficit on the basis of the best available evidence. The first two sections explain the relevant basic science and present detailed information on the available technologies and techniques, including the most recent advances. The radiotherapy strategies appropriate in different patient groups are then fully described, covering the use of ablative, adjuvant, neoadjuvant, and definitive radiotherapy, radiotherapy as a bridge to liver transplantation, and palliative radiotherapy. The final section addresses a range of specific issues of concern to the clinician. Radiotherapy of Liver Cancer will be an ideal reference for clinical radiation oncologists, radiation oncology residents, oncologists, and hepatologists.

This book, in MCQ format, is a comprehensive tool that will help Nuclear Medicine and Radiology residents and attending physicians to understand concepts in nuclear medicine. Questions cover clinical applications of nuclear medicine techniques to the cardiovascular, pulmonary, endocrine, skeletal, gastrointestinal, genitourinary, and central nervous systems. In addition, topics in physics, radiopharmacy, and radiation safety are addressed. The MCQ format closely resembles that used in board examinations in nuclear medicine. Each question has four possible answers, only one of which is correct. About 60% of the questions are linked to clinical cases, with each case having four questions on average, along with one or two images. The remainder of the questions are free-standing, with or without an image. Answers are concise but are supported by references to the literature when necessary. Pearls in boxes are used to highlight the most important pieces of information. While the questions are scrambled, as in board exams, an index categorizes each question into one of the systems or topics. .

Introduction and overview of rainbow program -- Psychoeducation about pediatric bipolar disorder -- Affect regulation skills for parents -- Affect regulation skills for children -- Coping skills for children -- Coping and positive thinking for parents -- Respectful communication and social skills for children -- Promoting social skills and a balanced life for parents -- Family problem solving -- Creating pleasant memories and finding support -- Reflecting on rainbow experience and tools learned -- Final celebration.

"Jenna Arnold, director of strategic engagement for the historic 2017 Women's March, helps American white women (one of the most powerful demographics in the world-but too often passive) understand how their influence, power, and voice can better serve those most in need, and how you can take an active role in creating a better future"-- Provided by publisher.

Medical treatments designed to help people can also be harmful or fatal. Around 2.5 million people die this way each year. So if any kind of medicine makes someone unwell, they or their doctor should report it. Those reports, from nearly every country in the world, go to the Uppsala Monitoring Centre (UMC) in Sweden. As the Centres first director, Professor Ivor Ralph Edwards transformed it from a tiny operation with limited horizons into an internationally acclaimed scientific organization at the heart of the World Health Organizations Programme for International Drug Monitoring. He was then succeeded by his wife, Dr Marie Lindquist. This is the story of how a new science developed and a passionate and dedicated pursuit of worldwide medicines safety, with an unerring focus on the welfare of patients. The pioneering work of Ralph, Marie and their collaborators on every continent protected the lives of millions of people. It may yet improve the lives of billions more.

This introduction to random walks on infinite graphs gives particular emphasis to graphs with polynomial volume growth. It offers an overview of analytic methods, starting with the connection between random walks and electrical resistance, and then proceeding to study the use of isoperimetric and Poincar inequalities. The book presents rough isometries and looks at the properties of a graph that are stable under these transformations. Applications include the 'type problem': determining whether a graph is transient or recurrent. The final chapters show how geometric properties of the graph can be used to establish heat kernel bounds, that is, bounds on the transition probabilities of the random walk, and it is proved that Gaussian bounds hold for graphs that are roughly isometric to Euclidean space. Aimed at graduate students in mathematics, the book is also useful for researchers as a reference for results that are hard to find elsewhere.

"It is now more than ten years since the first edition of this book was published. In the intervening years, while many things have remained unchanged, there have also been many new developments over the period. This second edition refreshes the first, refining some of the sections to better explain their contents and, at the same time, replacing some examples with more current illustrations. To reflect the changes, we have created new chapters by splitting and then expanding old chapters. Thus, we now include full chapters on data and safety monitoring including interim analyses of accumulating data, cluster designs, repeated measures, and non-inferiority designs as there has been a rapid increase in the use of such trial designs along with some methodological developments and improvements in statistical software available for analysis. In addition, we have included entirely new chapters on stepped wedge designs, genomic targets and, feasibility and pilot studies. The chapter on stepped wedge designs reflects the growing importance of such complex intervention designs while that on genomic targets highlights the research focus directed towards more individualised medicine. In contrast the new chapter concerned with feasibility and pilot studies brings us back to the early planning stages of the clinical trial which is planned. The chapter is included as there is increasing recognition that perhaps a more structured approach is required at the planning stage of any proposed trial. The intention is to help avoid the conduct of clinical trials which fail due to the basic assumptions made at the planning stage being inappropriate. This edition is divided into three sections: I Basic Considerations, II Adaptions of the Basic Design, and III Further Topics. As the title suggests, the first section is intended to cover topics that are relevant to all randomised trials of whatever design and complexity. Thus, it may be the key section for those who are new to clinical trials and an aide-memoire for those more experienced in this area. For this purpose, it concentrates on the parallel two-group controlled trial with a single outcome measure where patients are randomised individually to one of the two interventions concerned. The second section expands on the individually randomised design in several ways by considering paired designs, repeated assessments of the (same) outcome measure over time, more than two interventions, and non-inferiority trials. It also includes cluster trials, and stepped wedge designs in which groups rather than individuals are randomised to the interventions concerned. The final section deals with genomic targets, feasibility and pilot studies, and a final chapter on miscellaneous topics including adaptive designs, large simple trials and very small trials with new additions describing alpha spending functions and the predictive probability test for use in interim analyses"-- Provided by publisher

Children are not just small adults -- The physis and skeletal injury -- Orthopedic literacy : fracture description and resource utilization -- Emergency fracture reduction -- Casts for children's fractures -- Clavicle -- Shoulder and humeral shaft -- Elbow : distal humerus -- Elbow : proximal radius and ulna -- Radius and ulna -- Hand and wrist -- Pelvis and hip -- Femoral shaft -- Knee -- Tibia and fibula -- Ankle -- Foot -- Spine -- Fractures in special circumstances -- Accident prevention, risk, and the evolving epidemiology of fractures.

Ranunculales is an order of flowering plants belonging to a paraphyletic group known as the basal eudicots. Medicinal plants of this order provide myriad pharmaceutically active components commonly used worldwide in ethnomedicine and traditional Chinese medicine. Interest in plant-based medicinal resources has led to discoveries of many novel compounds in various species, and to investigations on their chemodiversity, biodiversity and pharmacotherapy. Ranunculales Medicinal Plants covers this order of flowering plants comprehensively in this context; detailing the phytochemistry, chemotaxonomy, molecular biology, and phylogeny of selected medicinal plants families and genera, and their relevance to drug efficacy. The book carries out an exhaustive survey of the literature in order to characterize global trends in the application of flexible technologies. The interrelationship between Chinese species and between Chinese and non-Chinese species is inferred, in the text, through molecular phylogeny, based on nuclear and chloroplast DNA sequencing. The title discusses the conflict between chemotaxonomy and molecular phylogeny, in the context of drug discovery and development. It offers invaluable and holistic coverage for the study of Ranunculales as a pharmaceutical resource.

This volume provides practitioners with a practical, easy to read, well organized approach to the performance and analysis of urodynamics in order to optimize their usage clinically. Chapters are structured around specific types of patterns seen on urodynamic tracings. These urodynamic tracings are annotated and fully interpreted by the authors. Multiple examples of each type of tracing are provided with expert commentary. The expert commentary expands on the potential clinical significance of the tracing, provides a differential diagnosis, and, where appropriate, discusses its importance diagnostically, prognostically and the implications for clinical management. The text contains chapters on virtually all the relevant urodynamic findings and clinical conditions seen in practice, including lower urinary tract conditions in both adults and children, neurogenic and non-neurogenic dysfunction, and other commonly seen conditions such as lower urinary tract obstruction, vaginal prolapse, and detrusor overactivity. The material is also presented in a practical manner, with special consideration to the latest national and international guidelines. Written by authorities in the field, Rapid and Practical Interpretation of Urodynamics is a valuable resource that fills a key gap by providing a systematic method of interpretation of urodynamic tracings in an easy to understand textbook that will benefit urologic trainees and experienced urologists alike.

Cardiovascular -- Ear, nose & throat (ENT) -- Gastroenterology -- Genitourinary -- Infections, sepsis & infectious diseases -- Mental health emergencies -- Musculoskeletal -- Neurology -- Obstetric & gynecology -- Opthalmology -- Overdose & poisoning -- Respiratory -- Skin -- The electrocardiogram.

The Rapids are a series of reference and revision pocket books that cover key facts in a simple and memorable way. Each book contains the common conditions that students and newly qualified nurses encounter on the wards, in the community, and on placements. Only the basic core relevant facts are provided to ensure that these books are perfect and concise rapid refreshers. Rapid Infection Control Nursing is an essential read for all frontline nursing staff working in hospitals or community settings. Designed for quick reference, it explores the essential principles of infection.

This book introduces basic ROSE techniques and resources required to set up ROSE service. It reviews the cytomorphologic features that are recognizable during ROSE, including those important for sample adequacy, specimen triage, preliminary interpretation, and potential diagnostic pitfalls. Economic and regulatory aspects are discussed as well as the pros and cons of telecytology. The book is formatted for clinical settings, simulating the ROSE process that occurs in the ultrasound room, CT room, bronchoscopy suite, and endoscopy suite. Each chapter focuses on the cytomorphologic clues and pitfalls of the entities specific to that clinical setting. Rapid On-Site Evaluation: A Practical Guide will be a valuable resource for pathologists, cytotechnologists, physicians who perform biopsies and/or ROSE evaluation, and trainees for utilizing ROSE and improving diagnostic performance of biopsies.

This book demonstrates the recent advances in rapid on-site evaluation (ROSE) for differential diagnosis of interstitial lung disease (ILD). Interstitial lung disease is a group of diffuse parenchymal lung disorders affecting the interstitium, a part of the lung's anatomic structure, causing inflammation, scarring, or excess fluid. ILDs include interstitial pneumonia, idiopathic pulmonary fibrosis, nonspecific interstitial pneumonitis, cryptogenic organizing pneumonia and sarcoidosis, which are associated with various degrees of morbidity and mortality rates. ROSE has proven its value in diagnosis with routine transbronchial lung biopsy (TBLB) procedures, especially in difficult clinical cases. The first part of the book discusses the principals of performing ROSE procedures, reviews the basic concepts and summarizes the distribution and morphology of tracheal/ bronchial/ pulmonary cells. The second part covers specific interstitial disorders, including a number of difficult and rare cases, and features iCT images and cytological illustrations. Providing readers with valuable insights, the book is an important resource for practitioners involved in the care and treatment of patients with ILD. This book is part of the 4-volume collection ROSE in Diagnostic Interventional Pulmonology.

This book offers cutting-edge evidence on using rapid on-site evaluation (ROSE) for the diagnosis of neoplastic diseases in pulmonology. ROSE has become an efficient interventional diagnostics tool and important reference for lung disease differentiation, increasing the adequacy rate, diagnostic yield and accuracy of interventional pulmonary procedures. By performing a rapid stain in the bronchoscopy suite, with evaluation by a trained physician, ROSE can be used to ensure the collection of suitable and sufficient material for ancillary studies in an era of caner-targeted therapy. ROSE holds considerable value in terms of evaluating sampling adequacy for further immunohistochemistry testing, microbiology studies, flow cytometry analysis, and molecular assays, providing a preliminary diagnosis for patient care. The first part of the book discusses the key principles for performing ROSE procedures and reviews key anatomical structures in the lung. It also covers typical cellular characteristics on the ROSE scale for pulmonary solid malignancies. The second part of the book features abundant figures and illustrations of ROSE cytopathology in common neoplastic diseases, e.g. adenocarcinoma, squamous-cell carcinoma and small cell lung cancer, while also exploring more unusual types, e.g. pneumonia-type carcinoma of the lung (PTCL), mucinous adenocarcinoma, lung mixed carcinoma, pulmonary metastases from extrapulmonary primary tumors, large cell neuroendocrine carcinoma (LCNEC), and lymphoma. This book is part of the 4-volume collection ROSE in Diagnostic Interventional Pulmonology.

This book covers up-to-date evidence of Rapid on-site evaluation (ROSE) for diagnosis of rare disease and used combined with metagenomic sequencing technique in clinical scenarios. ROSE has becoming an efficient interventional diagnostics tool and important reference for lung diseases differentiation, increasing the adequacy rate, diagnostic yield and accuracy of the interventional pulmonary procedures. ROSE has its value in the field of evaluating sampling adequacy for further immunohistochemistry, microbiology studies, flow cytometry analysis, and molecular assays; DNA analysis of biopsy specimens using sequencing technique is performed to provide clue of etiology, which is an emerging pathway for clinical dilemmas. The first part of the book discusses the principals of performing ROSE procedures and reviews the basic concepts and summarized knowledge of key anatomical structures in lung. Figures of ROSE cytopathology, together with clinical data, results of metagenomic sequencing technique are presented to demonstrate how the difficulties in clinical practice could be tackled with the help of advanced techniques. Further application direction and perspective are also discussed, which provides researchers with more insights on the discipline and techniques. This book is part of the 4-volume collection ROSE in Diagnostic Interventional Pulmonology.

This book provides a comprehensive overview of the "real-time accompany technique" for diagnostic interventional pulmonology, known as rapid on-site evaluation (ROSE). It also offers readers a detailed understanding of how to interpret ROSE cytological slides, which is key to the interventional procedure itself and valuable in the analysis of the infectious disease status. The first part discusses the ROSE procedure, clarifying the role of ROSE in the diagnosis of respiratory diseases, while further sections address correct work processes and the implications of ROSE, incorporating multidisciplinary perspectives on respiratory diseases, interventional pulmonology, pathology, clinical microbiology and infectious diseases. This helps practitioners, such as pulmonologists, interventional physicians, radiologists, critical care physicians, haematologists and rheumatologists, establish standardized clinical practices. The book also covers detailed clinical workups, including presentations of lesions, which are of interest to physicians from other specialties.

This book provides an overview of the use of rapid prototyping in patients with cardiac pathology. With the exponential increase in the use of prototyping, or 3D printing technology, medical applications are becoming more widespread across specialties. Although medical centers are beginning to apply this technology for improved patient care, there is no single text to which specialists can refer for guidance about this emerging modality. The book discusses the use of rapid prototyping in medicine; model creation; image acquisition; rapid prototyping techniques; applications in congenital and structural heart disease; and development and management of a rapid prototyping service. The use of rapid prototyping for pre-procedural planning in patients with cardiac disorders such as septal defects, Tetralogy of Fallot, transcatheter aortic valve replacement, and ventricular assist devices and heart transplant significantly enhances visualization of cardiovascular anatomy. Rapid Prototyping in Cardiac Disease is a unique and valuable resource for cardiac imaging specialists, cardiothoracic surgeons, radiologists, and biomedical engineers.

The approach to total hip and total knee arthroplasty is changing around the world. There is now a strong emphasis on a more rapid recovery and on more outpatient surgery. Each step of the process is now being modified with more thorough pre-operative evaluations, streamlined surgical approaches, rapid mobilization and faster return to normal activities. These changes place new pressures on all of the health care providers in the system. This unique text - the first of its kind - is a practical guide for each member of the clinical team with updates by the leading authorities from around the country. Each chapter addresses a specific issue and will outline the important new items that need to be addressed, very similar to a handbook. Topics covered include the implementation of new payment models and outcome measurements, recommendations to streamline the pre-, peri- and post-operative protocols, the utility and application of outpatient joint replacement programs, multimodal pain management and post-acute rehabilitation strategies. There is no publication at present that addresses all of these items together in one convenient place. Rapid Recovery in Total Joint Arthroplasty is written and edited by experienced clinicians and surgeons, sharing their years of experience to create a practical, up-to-date text useful for everyday work. .

"Careful monitoring of at-risk patients, early intervention, and timely escalation to the critical care unit from a general ward has been shown to improve patient clinical outcomes. The first text of its kind in this important area, Rapid Response Events in the Critically Ill: A Case-Based Approach to Inpatient Medical Emergencies is designed to help you recognize the fundamental signs of deterioration in patients on medical wards and ensure that transfer is made to the ICU before the development of adverse clinical outcomes. Using a highly effective teaching approach preferred by both residents and fellows, this innovative text links theory to practice with a brief review of clinical cases sourced from various academic centers"-- publisher's description.

"Written for trainees who are preparing to take the Anesthesia Oral Board exam, Rapid Review Anesthesiology Oral Boards is focused on the most commonly tested topics on the ABA oral board exam. Presented in a question-and-answer format, the book covers 39 different clinical scenarios encountered in the exam, including the Parkland formula to calculate fluid resuscitation in burn patients, ICP monitoring in craniotomy and hemodynamic goals in patients with cardiac disease. Questions follow the normal course of a case, from pre-operative assessment to intra-operative management and post-operative care. The answers to the questions are carefully structured to not only help the reader understand the medicine of anesthesia but also to provide the correct terminology needed to successfully pass the exam. This book is essential reading for trainees preparing for one of the toughest exams of their careers"--Provided by publisher.

This book is by Edward F. Goljan, MD, makes it easy for you to master all of the pathology material covered on the USMLE Steps 1 and 2. It combines an updated outline-format review of key concepts and hundreds of full-color images and margin notes, PLUS more than 400 USMLE-style online questions! Get all the practice you need to succeed on the USMLEs! New to this edition: Visualize key pathologic concepts and conditions with over 1,000 full-color images, completely reviewed and updated for this new edition.

This book makes it easy for you to master all of the pathology material covered on the USMLE Steps 1 and 2. It combines an updated outline-format review of key concepts and hundreds of full-color images and margin notes, PLUS more than 400 USMLE-style online questions! Get all the practice you need to succeed on the USMLEs! Visualize key pathologic concepts and conditions with over 1,100 full-color images, completely reviewed and updated for this new edition. Also includes many new high-yield, integrated margin notes and numerous summary table for more efficient studying and understanding of disease processes. -- Publisher description

[1] Diagnostic et traitement des hémorragies digestives aiguës / par Fr. Moyson et A. de Scoville avec la collaboration de S. Godart ... [et al.].

Patients with rare diseases, affecting less than 1 in 2000 persons, frequently experience delays or errors in diagnosis, sometimes with tragic consequences. Even after the diagnosis has been established, the quality of health care delivered is often poor. This book, which is both textbook and atlas, covers the full range of rare congenital genitourinary anomalies encountered in males and females, many of which have previously been described only in sporadic case reports. In the case of the more established anomalies, variants are presented. For each anomaly, information is provided on incidence, similar cases, clinical presentation, diagnosis, possible management and outcome. Informative supporting illustrations are presented for each anomaly, and the book will serve as an excellent reference for all pediatricians, urologists and surgeons who are responsible for the care of such patients.

This book provides a broad overview of rare disease drug development. It offers unique insights from various perspectives, including third-party capital providers, caregivers, patient advocacy groups, drug development professionals, marketing and commercial experts, and patients. A unique reference, the book begins with narratives on the many challenges faced by rare disease patient and their caregivers. Subsequent chapters underscore the critical, multidimensional role of patient advocacy groups and the novel approaches to related clinical trials, investment decisions, and the optimization of rare disease registries. The book addresses various rare disease drug development processes by disciplines such as oncology, hematology, pediatrics, and gene therapy. Chapters then address the operational aspects of drug development, including approval processes, development accelerations, and market access strategies. The book concludes with reflections on the authors' case for real-world data and evidence generation in orphan medicinal drug development. Rare Disease Drug Development is an expertly written text optimized for biopharmaceutical R & D experts, commercial experts, third-party capital providers, patient advocacy groups, patients, and caregivers.

This book focuses on predictive, preventative and personalised medicine (PPPM) and how it is related to the healthcare of rare diseases. Readers will discover how advanced rare diseases healthcare provides an excellent "proof-of-principles" for the personalisation of healthcare systems on a global scale. Chapters look at national plans for rare disease, at biobanking, gene identification, rare cancers, virus gene therapy, induced pluripotency for cell therapy amongst other topics. There is a chapter dedicated to personalised medicine for hereditary deafness, and another exploring the complexity of genotype-phenotype correlations. Specific diseases such as Fabry's, Gauchers and mitochondrial cytopathies are highlighted and we look at enzyme replacement therapy in lysosomal storage diseases. This work is part of a series, produced with the involvement of the European Association for Predictive, Preventive and Personalised Medicine. The series focusses on the concept of an integrative medical approach by PPPM. This volume is dedicated to all aspects related to the prediction, prevention and personalised treatments of rare diseases, and in doing so it explores developments relevant to all medical branches. The authors cover ethical considerations, the creation of a robust platform for professional communication, synergies with patient organisations, "doctor-patient" collaboration and a new philosophy of integrative medicine by PPPM. This volume serves as a reference source for scientific and medical centres in the field and can be used both at medical curricula and graduate level in the life sciences. Those who place a special emphasis on healthcare promotion and innovations intended to combat rare diseases, save the affected lives and enhance life quality will all find this book of great value.

Oncology -- Iatrogenic -- Infectious -- Neurology -- Genetic -- Vascular -- Idiopathic -- Metabolic -- Orthopaedic -- Miscellaneous.

This second edition of the book about Rare Diseases Epidemiology aims to highlight the progress of rare diseases research and related activities since the first volume published. As with the previous book, this update provides a comprehensive list of issues and adds new authors who are leaders in their different areas of expertise related to rare diseases at national and international levels. Rare diseases and orphan drugs are challenges for patients and families but also for physicians, researchers, and policy-makers in both the public and private sectors. This book aims to help all of them to address topics like health care policies, societal issues and clinical and experimental research. Readers will discover methods and procedures to address a variety of questions like cases of undiagnosed rare diseases, patient registries and biobanks, health care and public health approach to rare diseases, orphan drugs and new therapies, cost-effectiveness analyses, prevention, clinical and epidemiology of individual and groups of related rare diseases, novel advances in study design and data analyses, national and international policies and social issues. Within each one of these general issues, advances, new challenges and opportunities to address significant health care issues are described across thirty-two chapters. Editors and all authors providing chapters include globally recognized experts in different areas of rare diseases, including epidemiology, public health, health economics and pharmacology, statistics, and basic, clinical and translational research. People engaged in policy formulation decisions on rare diseases as well as patient representatives relate their own point of view about social constraints they live under on a daily basis. Renowned research investigators, highly-skilled clinicians, and recognized patient leaders are included as contributing authors to this new book about rare diseases. In fact, two of the editors are the current President and President Elect of the International Conference on Rare Diseases and Orphan Drugs and the third one is a board member of this society. The book has been written for all stakeholders but mainly for those involved in the many issues related to rare diseases. They can discover new ways for dealing with important matters related to the prevention, diagnosis, natural history, treatments, and research of rare diseases and the development of orphan products. .

Methods in Enzymology, Volume 650 continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include Biophysical methods to study lanthanide-protein interactions, Genetically encoded sensors to study lanthanide biology, Spectrophotometric methods to determine the stability constants of lanthanide-macromolecule complexes, Lanthanide-based probes for amino acid modifications, In vitro selection and application of lanthanide-dependent DNAzymes, LRET biosensors for imaging protein interactions in living cells, Synthetic Modeling of the Structure and Function of the Lanthanide-Dependent, MDH Cofactor, EPR spectroscopy of lanthanides, Macromolecular crystallography for f-element complex characterization, and much more.

Papillary Renal Cell Carcinoma -- Renal Medullary Carcinoma -- Translocation Renal Cell Carcinomas -- Primitive Neuroectodermal Tumors and Other Sarcomas of the Kidney -- Adult Wilms' Tumor -- Urothelial Carcinoma with Variant Histology: Sarcomatoid, Plasmacytoid, and Micropapillary -- Primary Sarcomas and Other Sarcomatoid Tumors of the Bladder -- Neuroendocrine and Small Cell Carcinomas of the Urinary Tract -- Urachal and Non-urachal Adenocarcinoma of the Bladder -- Primary Urethral Carcinomas -- Adenocarcinoma of the Urethra -- Primary Urethral Melanoma -- Neuroendocrine and Small Cell Carcinomas of the Prostate: Sentinels of Lethal Evolution -- Mucinous, Signet Ring, Ductal, and Sarcomatoid Variants of Prostate Cancer -- Prostate Sarcomas and Squamous Cell Carcinomas -- Sex Cord Stromal Tumors of the Testis -- Granulosa Cell Tumors of the Testis -- Squamous Cell Carcinoma of the Penis and Scrotum -- Basal Cell Carcinoma of the Male External Genitalia -- Extra-mammary Paget?s Disease -- Kaposi?s Sarcoma of the Penis and Scrotum -- Rare Tumors of the Vulva.

Advances in genetic testing for cancer predisposing genes -- Diagnosis and management of inheritable pheochromocytomas and paragangliomas -- Diagnosis and management of inheritable kidney cancer syndromes -- Diagnosis and management of inheritable pancreatic cancers/melanomas -- Diagnosis and management of inheritable basal cell skin cancer syndromes -- Diagnosis and management of inheritable adrenal cancers -- Diagnosis and management of inheritable thyroid cancers -- Diagnosis and management of inheritable meningiomas/acoustic neuroma -- Diagnosis and management of inheritable gastric cancer syndromes -- Diagnosis and management of inheritable carcinoid syndromes -- Diagnosis and management of inheritable sarcoma syndromes -- Genetic testing for rare cancer syndromes: the wider issues for patients, families and health professionals.

The past decade has witnessed tremendous progress in the diagnostic and therapeutic approaches to malignant lymphoma as well as in understanding of the underlying molecular pathogenesis. Optimal treatment strategies are now based not only on accurate diagnosis but also on thorough evaluation of clinical and molecular risk factors. Even more importantly, molecular targeted approaches have been shown to be effective in the treatment of distinct lymphoma subtypes. Against this background, clinical management of especially the rare lymphomas remains a challenge for the general oncologist. This book provides a comprehensive overview of current treatment strategies in these rare lymphoma subtypes. Experts in the field from around the world describe the histomorphology in a clinically relevant manner, consider the role of risk factors in detail, and discuss the spectrum of therapeutic approaches. Special emphasis is placed on the translation of molecular science into clinical care, and a disease-specific algorithm is proposed for each entity. This book will prove an excellent resource for both experienced and inexperienced practitioners.

This book provides practitioners with a single volume that reviews the clinical and pathologic features of rarely encountered cutaneous neoplasms. The text includes an in-depth discussion of the clinical findings, as well as the histologic and immunologic features of these diseases that are rarely encountered, reported, or recognized. Additional laboratory data used to make and support the diagnoses with some therapeutic and prognostic hints are discussed for each entity. The volume is organized into general categories correlating with the cell(s) of origin. An atlas of clinical manifestations is presented for each entity that will serve as a bedside clinical reference, followed by a series of photomicrographs depicting the histologic changes. In all cases, recent updates on molecular tools helpful in attaining the diagnosis are added to the sections on histology and immunohistochemistry. Rare Malignant Skin Tumors is a valuable bedside reference for the practicing dermatopathologist, general pathologist reviewing skin biopsies, general dermatologists, cutaneous oncologists and Mohs? surgeons.

This is the first book to be devoted exclusively to rare tumors in children and adolescents. The completely revised and updated second edition reflects the significant progress that has been accomplished as a result of intensified international networking, deeper implementation of novel diagnostic tools, and the advent of molecular targeted therapies. Readers will find practical guidance on all aspects of clinical management, including diagnostic workup, multimodal therapy, follow-up, and management of adverse effects. The discussion of differential diagnosis encompasses both frequent and rare tumor types, enabling clinicians to take rare entities into account during diagnostic assessment of childhood tumors. Detailed therapeutic recommendations, developed in an international consensus process, are provided for specific rare tumors. In addition, general issues such as epidemiology, etiology, risk factors, biology and genetics, early detection, and screening are fully covered. The book is written by an international and multidisciplinary group of specialists and will be an important compendium for all pediatric oncologists who care for patients with rare tumors.

This volume on Rarer Arthropathies, part of the series "Rare Diseases of the Immune System" aims to fill a gap in the literature by informing and updating clinicians on the unusual and uncommon forms of arthritis and related musculoskeletal conditions. It will be a valuable go-to resource for clinicians to support them in differential diagnosis, in particular when facing unusual presentations. Nineteen chapters written by experts have covered a wide range of these conditions, providing first rate information on topics yet lacking adequate coverage; from Palindromic Rheumatism to SAPHO Syndrome and other chronic immune-mediated conditions, while also including arthritis in leprosy, tuberculosis and chikungunya. Smaller, crisp paragraphs and apt subheadings will help the readers in easily understanding the up to date information provided in the chapters. Line diagrams, original full-color clinical photographs and informative tables also support easy assimilation of information, turning this book in a useful ready reckoner on the desks and smartphones. All specialists, including rheumatologists, orthopedic surgeons, pediatricians, physicians practicing internal medicine and rehabilitation medicine will find this volume invaluable in their daily clinical work.

"Advances in Cancer Research, volume 153 provides a timely review of the biology, biochemistry, and current approaches to therapeutically target the RAS oncoprotein, the most frequently mutated oncogene family in human cancers. 2021 saw the approval of the first direct RAS inhibitor (sotorasib) for use in treating non-small cell lung cancers harboring KRAS(G12C) mutations. The successful approval and use of this drug highlights that the once "undruggable" RAS is indeed pharmacologically tractable. This volume provides an overview of efforts to develop additional approaches to therapeutically target oncogenic RAS. In addition, the reader will find excellent reviews on the history and research efforts to understand the biochemistry and oncogenic activity of RAS in human cancers."--publisher's web page, viewed February 1, 2022.

The Ras superfamily of small GTPases : the unlocked secrets / Luca Goitre [and three others] -- A novel method for the production of fully modified K-Ras 4B / Tanmay S. Chavan [and four others] -- Metabolic labeling of Ras with tritiated palmitate to monitor palmitoylation and depalmitoylation / Frederick D. Tsai [and three others] -- Ubiquitination of Rac1 by inhibitors of apoptosis (IAPs) / Tripat Kaur Oberoi-Khanuja and Krishnaraj Rajalingam -- Ras GTPases are both regulators and effectors of redox agents / Elisa Ferro [and four others] -- Biophysical and proteomic characterization strategies for cysteine modifications in Ras GTPases / G. Aaron Hobbs, Harsha P. Gunawardena, and Sharon L. Campbell -- Use of the yeast two-hybrid technology to isolate molecular interactions of Ras GTPases / Elisa Ferro, Eva Baldini, and Lorenza Trabalzini -- Screening for MAPK modulators using an In-Cell Western assay / Simon Schnaiter [and seven others] -- Behavioral methods for the study of the Ras-ERK pathway in memory formation and consolidation : passive avoidance and novel object recognition tests / Raffaele d'Isa, Riccardo Brambilla, and Stefania Fasano -- Functional phosphoproteomics of oncogenic KRAS signaling / Putty-Reddy Sudhir and Jeou-Yuan Chen -- Pull-down assay for analysis of integrin-mediated activation of Rap proteins in adherent platelets / Gianni Francesco Guidetti and Mauro Torti -- Combined pulldown and time-lapse microscopy studies for determining the role of Rap1 in the crosstalk between integrins and cadherins / Luca Goitre and Saverio Francesco Retta -- Fluorescence microscopy study of Rap1 subcellular localization / Luca Goitre, Valentina Cutano, and Saverio Francesco Retta -- An in vitro system to evaluate the scaffold function of the RalA effector protein RalBP1 / David F. Kashatus -- Analysis of the Rit subfamily GTPase-mediated signaling and neuronal differentiation and survival / Geng-Xian Shi and Catherine N. Kaminski -- Immunofluorescence methods in studies of the GTPase Ran and its effectors in interphase and in mitotic cells / Giulia Guarguaglini, Valeria de Turris, and Patrizia Lavia -- High-resolution scanning electron microscopy for the imaging of nuclear pore complexes and Ran-mediated transport / Lihi Shaulov, Boris Fichtman, and Amnon Harel -- Effector recruitment method to study spatially regulated activation of Ras and Rho GTPases / Lauren P. Huff, Molly J. DeCristo, and Adrienne D. Cox -- Real-time visualization and quantification of native Ras activation in single living cells / Christoph Biskup and Ignacio Rubio -- Nanoclustering and heterogeneous membrane diffusion of Ras studied by FRAP and RICS analysis / Camilo Guzmâan, Maja éSolman, and Daniel Abankwa -- Analyzing the roles of Rho GTPases in cancer cell migration with a live cell imaging 3D-morphology-based assay / Audrey Colomba and Anne J. Ridley -- Analysis of Rho GTPase-induced localization of nanoscale adhesions using fluorescence nanoscopy / Annica K.B. Gad [and three others] -- Yeast as a model for Ras signalling / Renata Tisi, Fiorella Belotti, and Enzo Martegani -- Methods to study the Ras2 protein activation state and the subcellular localization of Ras-GTP in Saccharomyces cerevisiae / Sonia Colombo and Enzo Martegani -- Ras proteins signaling in the early metazoan Dictyostelium discoideum / Enrico Bracco and Barbara Pergolizzi.

Raspberry is a globally-significant soft fruit crop, with increasing interest to consumers due to its versatility and health-related constituents. In this background context, it is therefore timely to consider the present and future status of the raspberry crop, particularly with the advances in the use of molecular tools and plant phenotyping to improve our understanding of improving crop quality and fruit yields. Since the 1980s a wealth of fundamental genomics and metabolomics resources have been developed for soft fruits including linkage maps, physical maps, QTLs and expression tools. However, a number of serious and emerging challenges exist for the raspberry industry, including the plants' ability to resist major pest and disease burdens and the impact of climate change on crop production, specifically water use and water availability for soft fruit crops. This book aims to address some of these challenges by updating the information known about this important crop, its health value, the major pest and diseases which affect raspberry and approaches for their control, and the speed and precision offered by selective breeding programs by the deployment of molecular tools and linkage maps for germplasm assessment. Understanding the genetic control of commercially and nutritionally important traits and the linkage of these characteristics to molecular markers on chromosomes is the future basis of plant breeding. We will also introduce the opportunity to fast track breeding by improving the speed of phenotypic selection by utilizing imaging sensor technologies, thereby reducing the cost of years of field assessment through developing this knowledge into markers linked to key fruit traits.^The chapters of this book will span the knowledge gained from the collaborations between growers, plant breeders, plant physiologists, soil scientists, geneticists, agronomists and physicists which is essential to achieve progress in improving productivity and a sustainable industry.

Written specifically for non-infectious disease specialists in both inpatient and outpatient settings, A Rational Approach to Clinical Infectious Diseases provides concise, practical guidance that mimics the decision-making process and reasoning employed by an ID physician. Using clear, understandable language, Dr. Zelalem Temesgen and his esteemed colleagues at the Mayo Clinic present the art and the context of infectious diseases together with the science, helping non-specialists apply a rational approach to the diagnosis and treatment of infectious conditions.

Introduction (McCue) -- Elderly suicide through history (McCue) -- Acceptability of elderly suicide across cultures -- Baby boomers and the wish to control life and death -- Can suicide in the elderly be rational? (Lawrence Nelson) -- Clinical criteria for rational suicide in the elderly -- Who are the elderly who want to end their lives? -- Existential issues in late-life rational suicide -- Psychological issues in late-life rational suicide (Elissa Kolva) -- Psychodynamic issues in late-life rational suicide (Balasubramaniam) -- Terminal mental illness and the wish to die (Barbara Sommer) -- The impact of spirituality on the rationality of suicide -- The impact of psychotherapy on the rationality of suicide (Elissa Kolva) -- The impact of psychopharmacology on the rationality of suicide (Balasubramaniam) -- Commentary.

Abt. 2. Knochen, Bänder -- Abt. 3. Muskeln, Gefässe -- Abt. 4. Eingeweide -- Abt. 5/6. Nervensystem, Sinnesorgane : nebst Anhang, Grundzüge der Oberflächen- und Projektions-Anatomie.

This book, the only one of its kind on ravine lands, reflects the significant advances made over the past two decades in our understanding of gully erosion, its controlling factors, and various aspects of gully erosion. It also addresses central research gaps and unanswered questions, which include historical studies on gully erosion to better understand the different stages of their formation; appropriate measuring techniques for monitoring or assessing the geological and hydrological parameters and processes involved in gully development; interaction of hydrological and other soil degradation processes; ecology and biodiversity of fragile ravines; impact of climate and environmental changes on soil erosion processes; development of effective and reliable gully erosion models; effective gully prevention and control measures; watershed-based management options; and ravine rehabilitation policies. The present book is a highly timely publication and deals with various aspects of ravine ecology and rehabilitation of degraded lands, particularly with the aid of biological approaches. As such, it offers a valuable guide for all scientists working in the fields of soil conservation / rehabilitation and agroforestry, students, environmentalists, educationists, and policymakers. More importantly, it focuses on the rehabilitation of one of the world's most degraded and fragile ecosystems, ensuring the livelihoods of resource-poor farmers and landless families living in harsh ecologies that are more vulnerable to climate change.

Normal tissue tolerance to reirradiation -- Fractionation concepts -- Hyperthermia and reirradiation -- Therapeutic ratio of reirradiation with cytotoxic drugs and other response-modifying agents -- Reduced normal tissue doses through advanced technology -- Proton beam reirradiation -- Brain tumours -- Eye tumors -- Re-irradiation in head and neck cancer -- Nasopharyngeal carcinoma -- Lung cancer -- Re-irradiation for esophageal cancer -- Re-irradiation for locally recurrent breast cancer -- Prostate cancer -- Rectal cancer -- Gynecological malignancies -- Reirradiation for soft tissue sarcomas -- Re-irridation for recurrent skin cancer -- Leukemia and lymphoma -- Bone metastases -- Brain metastases -- Index.

"Tell the doctor where it hurts." It sounds simple enough, unless the problem affects the very organ that produces awareness and generates speech. What is it like to try to heal the body when the mind is under attack? In this book, Dr. Allan Ropper and Brian Burrell take the reader behind the scenes at Harvard Medical School's neurology unit to show how a seasoned diagnostician faces down bizarre, life-altering afflictions. Like Alice in Wonderland, Dr. Ropper inhabits a world where absurdities abound: A figure skater whose body has become a ticking time-bomb. A salesman who drives around and around a traffic rotary, unable to get off. A college quarterback who can't stop calling the same play. A child molester who, after falling on the ice, is left with a brain that is very much dead inside a body that is very much alive. A mother of two young girls, diagnosed with ALS, who has to decide whether a life locked inside her own head is worth living. How does one begin to treat such cases, to counsel people whose lives may be changed forever? How does one train the next generation of clinicians to deal with the moral and medical aspects of brain disease? Dr. Ropper and his colleague answer these questions by taking the reader into a rarified world where lives and minds hang in the balance"-- Provided by publisher.

Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term 'oxidative stress' is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com

This book highlights the latest advances made in the niche area of Reactive Oxygen Species and Redox processes in plants. It offers a valuable guide for researchers and students alike, providing insights into sensing, detox scavenging, the role in oxidative deterioration, and signaling associated with redox-regulatory processes in plants. The book also dramatically demonstrates how these amazingly resourceful molecular species and radicals are poised at the core of a sophisticated network of signaling pathways, and act as vital regulators of plants cell physiology and cellular responses to the environment. The molecular language associated with ROS-mediated signal transduction, which produces modulations in gene expression that determine plants stress acclamatory performance, is also discussed. The book subsequently provides information on current trends in redox proteomics and genomics, which include efforts to gain a fuller understanding of these redox players role in cellular processes, and to further the application of this knowledge to technology and agriculture. Given its scope and format, the book offers a valuable asset for students of Plant Sciences, Agriculture, and Molecular Biology, as well as readers engaged in research on and teaching ROS Biology.

1. Introduction to scientific reading and writing and to technical modalities of augmentation -- 2. Ecrilecture and the constructino of knowledge within professional communities -- 3. "Critical spaces": a study of the necessary conditions for scholarly and multimedia reading -- 4. "Annotate the world, and improve humanity": material imageries in a web annotation program -- 5. Construction of ecrilecture standards for collaborative trsncription of digitized heritage -- 6. The challenge of platform interoperability in constructing augmented knowledge in the humanities and social sciences -- 7. The XML portal for the symogih.org Project -- 8.Issues of "hypermediating journals" for scientific publishing.

"Reading EEGs: A Practical Approach focuses on pattern recognition and pattern comparison. The concepts of pattern recognition are developed in a logical fashion based on appearance rather than disease process. The book teaches waveform recognition so that the reader can generate a differential diagnosis based on that recognition. This book also incorporates a question-and-answer format that is effective for students at multiple levels of training"-- Provided by publisher.

"This funny, candid memoir about the author's intern year at a New York hospital provides a scorchingly frank look at how doctors are made, taking readers into the critical care unit to see one burgeoning physician's journey from ineptitude to competence. After his professional baseball career failed to launch, Matt McCarthy went to Harvard Medical School and on to a coveted residency slot in New York. But when he almost lost a patient on his first day after making what he believed to be a terrible error, he found himself facing the harsh reality of a new doctor's life--one in which even overachievers find themselves humbled, and in which med school training has little to offer in navigating the emotional rollercoaster of dealing with actual patients. Luckily for McCarthy, his second-year-resident adviser (whom he calls "Baio", owing to a resemblance to a Charles in Charge-era Scott Baio) was an offbeat genius, with a knack for breaking down the complicated process of treating patients. But neither doctor could offer much help to a patient named Barney, who had been living in the hospital while waiting for a new heart, and whom McCarthy slowly befriended over the course of the year in ways that changed his perception of what it means to be a physician. Mixing the tense drama of ER with the screwball humor of Scrubs, McCarthy offers a window on to hospital life that dispenses with sanctimony and self-seriousness while emphasizing the black-comic paradox of becoming a doctor: How do you learn how to save lives in a job where there is no practice? This "One L for doctors" will inspire and entertain physicians and patients alike"-- Provided by publisher.

"A novel of rare emotional power that excavates the social intricacies of a late-summer weekend -- and a lifetime of buried pain. Almost everything about Wallace, an introverted African-American transplant from Alabama, is at odds with the lakeside Midwestern university town where he is working toward a biochem degree. For reasons of self-preservation, Wallace has enforced a wary distance even within his own circle of friends -- some dating each other, some dating women, some feigning straightness. But a series of confrontations with colleagues, and an unexpected encounter with a young straight man, conspire to fracture his defenses, while revealing hidden currents of resentment and desire that threaten the equilibrium of their community"-- Provided by publisher.

This book describes the use of real-time three-dimensional transesophageal echocardiography (3D TEE) in percutaneous interventional procedures, underlining its growing role and acceptance among interventional cardiologists, while also considering technique-related weaknesses.

Intro -- Real-World Applications in Cognitive Neuroscience -- Copyright -- Contributors -- Contents -- Preface -- Chapter 1: Science of perception, decision making and fatigue in the maritime industry -- 1. Introduction -- 2. Perception at sea -- 2.1. Attention -- 2.2. Working in night lighting conditions -- 2.3. Lighting -- 2.4. What and where -- 2.5. Visual size and distance -- 3. Decision making at sea -- 3.1. Communication and culture -- 3.2. Trusting our guts -- 3.3. Group decisions -- 3.4. Fatigue -- 4. Conclusion: Using neuroscience to improve safety at sea -- Acknowledgments 2.3.1. Menstrual cycle mapping -- 2.4. Physiological training data -- 2.4.1. Physiological data analysis -- 2.5. Decision making tests -- 2.5.1. Cambridge gambling task (CGT) -- 2.5.2. CGT analysis -- 2.6. Qualitative methodology -- 2.6.1. Semi-structured interviews -- 2.6.2. Interview analysis -- 3. Results -- 3.1. Physiological data results -- 3.1.1. Whole group -- 3.1.2. Naturally menstruating group & oral contraceptive user groups -- 3.1.3. Individual participant analysis -- 3.2. Decision making results -- 3.2.1. Impulsivity -- 3.2.2. Risk taking -- 3.2.3. Response time -- 3.2.4. Error rates 3.3. Semi-structured interviews results -- 3.4. Results summary -- 4. Discussion -- 4.1. Physiological performance -- 4.1.1. Cognitive changes -- 4.1.2. Use of oral contraceptives as a management strategy -- 4.1.3. Recommendations -- 4.1.4. Competition and the menstrual cycle -- 4.1.5. Psychological management -- 4.1.6. Oral contraceptive use -- 4.1.7. Individual monitoring -- 4.2. Some limitations -- 5. Conclusion -- References -- Chapter 4: Assessing decision-making in elite academy footballers using real-world video clips -- 1. Introduction -- 2. Methods and materials -- 2.1. Participants 2.2. Experimental design -- 2.3. Statistical analysis -- 3. Results -- 3.1. Correlation between performance on the task and coaches opinion in all participants -- 3.2. Correlation between performance on the task and coaches opinion in the U16 group -- 3.3. Correlation between performance on the task and coaches opinion in the U18 group -- 3.4. Correlation between performance on the task and coaches opinion in the U23 group -- 4. Discussion -- References -- Chapter 5: Assessing decision making using 2D animations in elite academy footballers -- 1. Introduction -- 2. Method and materials

Human motivation: "In general why do people do what they do?" -- Human motivation: "Specifically why do people do what they do?" -- The counseling environment: "How do I set the stage for self-evaluation?" -- What is the WDEP system? -- Career concerns -- Cross-cultural applications -- Dealing with loss, posttraumatic stress, self-injury, conflict, and anger -- Reality threapy FAQs -- Conclusion.

"Realizing the Promise of Precision Medicine: The Role of Patient Data, Mobile Technology, and Consumer Engagement explains the potential of personalized medicine and the value of those approaches in making that potential a reality. The book helps transform one-size-fits-all healthcare into a system that focuses on individual needs and the unique needs of each family member, discussing topics such as U.S. sponsored precision medicine initiative, genomics, the role of electronic health records and mobile medicine, patient engagement and empowerment, health information exchange and patient data protection. In addition, the book discusses the barriers and limitations of precision medicine and how to overcome them. Readers will find valuable insights into how big data, patient engagement, mobile technology, and genomics help individualize medical care and offer a pathway to help detect many undiscovered causes of diseases.Provides drawings and flow charts to help readers visualize the breadth and depth of precision medicine includes sidebars with more details on specific topics for a complementary, deeper understanding of text. Uses case studies to turn abstract concepts into flesh and blood examples of how personalized medicine benefits patients"-- Provided by publisher.