BookHarald H.H.W. Schmidt, Pietro Ghezzi, Antonio Cuadrado, editors.
Summary: Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term 'oxidative stress' is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com
Contents:
Part I: ROS Revisited: Changing the Focus from Oxidative Stress and Redox Biology to Redox Medicine
Demystifying oxidative stress
Oxidants in Physiological Processes
Network Medicine-Based Unbiased Disease Modules for Drug and Diagnostic Target Identification in ROSopathies
Part II Targeting antioxidant responses
Development of Telintra as an Inhibitor of Glutathione S-Transferase P
Perspectives on the Clinical Development of NRF2-Targeting Drugs
Part III: Inhibiting ROS formation and toxification
NOX Inhibitors: From Bench to Naxibs to Bedside
Nitric Oxide Synthase Inhibitors into the Clinic at Last
Xanthine Oxidoreductase Inhibitors
Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches
Inhibition of Myeloperoxidase
Part IV: Stimulating/substituting ROS
Effects of Mammalian Thioredoxin Reductase Inhibitors
Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO" and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation
Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers
Part V: Repairing ROS damage
Soluble Guanylate Cyclase Stimulators and Activators
Peter Sander
Inhibitors of Advanced Glycation End Product (AGE) Formation and Accumulation.