Books

Dr. Georgia Young's wonderful life--great friends, family, and successful career--aren't enough to keep her from feeling stuck and restless. When she decides to make some major changes in her life, quitting her job as an optometrist, and moving house, she finds herself on a wild journey that may or may not include a second chance at love.

"The integrin family is composed of 24 members and approximately ten years ago (2003) we published a book devoted to the nine I domain integrin subunits. In this second edition, I am pleased that most of the original authors have been able to contribute to the updated version. I domain containing integrins include collagen receptors and leukocyte receptors. In 2003 the knockout mouse phenotypes for all of the I domain integrins had not yet been published; they are now, and are summarized and discussed in this edition. Interestingly, a recent 10 integrin mutation in dogs has indicated that collagen-binding integrins in the musculoskeletal system might have much more severe phenotypes in larger animals/humans compared to the mild integrin phenotypes observed in collagen-binding integrin deficient mice. This finding is further discussed in the book. In the cancer field, the microenvironment is taking center stage, and here collagen receptors on fibroblasts are predicted to play important roles in paracrine signaling, in regulating tissue stiffness and matrix remodeling. New technologies, new mouse models in combination with analyses of I integrins in larger animals/humans are thus predicted to increase our knowledge about this group of receptors. With this in mind we look forward to another 10 years of research with I domain integrins."--Publisher's wevsite.

The author's first encounter with a racialized America came at age seven, when her parents told her they named her Austin to deceive future employers into thinking she was a white man. She grew up in majority-white schools, organizations, and churches, and has spent her life navigating America's racial divide as a writer, a speaker, and an expert helping organizations practice genuine inclusion. While so many institutions claim to value diversity in their mission statements, many fall short of matching actions to words. Brown highlights how white middle-class evangelicalism has participated in the rise of racial hostility, and encourages the reader to confront apathy and recognize God's ongoing work in the world.

This open access book presents a wide portfolio of examples of positron emission tomography coupled with computer tomography (PET/CT) studies in various cardiac conditions in order to provide a rationale for the implementation of this technology in an array of clinical conditions. Cardiovascular diseases are a major contributor to premature morbidity and mortality worldwide. Low- and middle-income countries (LMICs) are particularly affected by cardiovascular diseases (CVDs), with more than 75% of all CVDs deaths occurring in these countries. For this reason, target 3.4 of the United Nations (UN) Sustainable Development Goals (SDGs) agenda aims at a 30% reduction in premature mortality due to non-communicable diseases (NCDs), which include CVDs, by 2030. Among CVDs, ischemic heart disease (IHD) plays an important role and, according to the Institute for Health Metrics and Evaluation (IHME), it was responsible for 15.96% of global deaths in 2017. Between 2000 and 2017, the number of IHD deaths worldwide increased by 0.26% per year. Several imaging tools help to non-invasively diagnose, stratify risk and guide management in cardiac disease. They include nuclear cardiology techniques, using either SPECT (single photon emission computed tomography) or PET/CT. While myocardial imaging with SPECT has been fully embraced by the cardiology community and is widely available worldwide, PET/CT introduction has been slower, due not only to its higher costs, but also to the limited availability of PET/VCT scanners, mostly utilized for oncological applications. This book is an invaluable tool for nuclear medicine physicians, cardiologists and radiologists.

This textbook includes 70 chapters contributed by an exceptional group of experts in all areas of hepato-pancreato-biliary diseases, bringing a multi-disciplinary approach to treatments. The book is designed to cover all aspects of the liver and pancreatic anatomy and pathology, as well as therapy. The topics are comprehensively reviewed, and as well as summarizing the previous works, the authors provide discussions of practice-changing techniques and approaches to therapy of HBP cancers. Treating the diseases in hepato-pancreato-biliary regions is particularly difficult due to the complex anatomy, aggressive biological behavior, and poor prognosis. Therefore, ample illustrations are included to tackle these challenges. The IASGO Textbook of Multi-Disciplinary Management of Hepato-Pancreato-Biliary Diseases aims to update the academic and non-academic medical professionals, such as surgeons, radiation oncologists, medical oncologists, gastroenterologists, interventional radiologists, radiologists, basic scientists. In collaboration with the International Association of Surgeons, Gastroenterologists and Oncologists (IASGO), delivers a valuable and well-organized textbook for medical professionals.

Classic epidemiology of lung cancer -- Tobacco control and primary prevention -- Assessing and treating tobacco use in lung cancer care -- Lung cancer in never-smokers : a different disease -- Gender-related differences in lung cancer -- Genetic susceptibility to lung cancer -- Screening for lung cancer -- Preclinical biomarkers for the early detection of lung cancer -- Chemoprevention of lung cancer and management of early lung cancer -- Copy number abnormalities and gene fusions in lung cancer : present and developing technologies -- Mutational events in lung cancer : present and developing technologies -- Epigenetic events in lung cancer : chromatin remodeling and DNA methylation -- Stem cells and lung cancer : in vitro and in vivo studies -- Microenvironment and lung cancer -- Micrornas as biomarkers for lung cancer -- Humoral and cellular immune dysregulation and lung cancer -- Classic anatomic pathology and lung cancer -- Molecular testing in lung cancer -- Management of small histologic and cytologic specimens in the molecular era -- Clinical presentation and prognostic factors in lung cancer -- Conventional imaging of lung cancer -- Positron emission tomography imaging of lung cancer -- Diagnostic workup for suspected lung cancer confined to the chest -- Preoperative and intraoperative invasive staging of the mediastinum -- The eighth edition of the tumor, node, and metastasis classification of lung cancer -- Preoperative functional evaluation of the surgical candidate -- Results of video-assisted techniques for resection of lung cancer -- Robotic surgery : techniques and results for resection of lung cancer -- Extent of surgical resection for stage i and ii lung cancer -- Extended resections for lung cancer : chest wall and pancoast tumors -- Extended resections for lung cancer : bronchovascular sleeve resections -- Multiple nodules : management of synchronous and metachronous lung cancers -- Surgical management of patients considered marginally resectable -- Technical requirements for lung cancer radiotherapy -- Radiobiology of lung cancer -- Patient selection for radiotherapy -- Stage i nonsmall cell lung cancer and oligometastatic disease -- Ablation options for localized nonsmall cell lung cancer -- Radiotherapy for locally advanced nonsmall cell lung cancer including combined modality -- Radiotherapy in the management of small cell lung cancer : thoracic radiotherapy, prophylactic cranial irradiation -- Palliative radiotherapy for lung cancer -- Acute and late toxicities of thoracic radiotherapy : pulmonary, esophagus, and heart -- Neurotoxicity related to radiotherapy and chemotherapy for nonsmall cell and small cell lung cancer -- Frontline systemic therapy options in nonsmall cell lung cancer -- Systemic options for second-line therapy and beyond -- Maintenance chemotherapy for nonsmall cell lung cancer -- Pharmacogenomics in lung cancer : predictive biomarkers for chemotherapy -- New targets for therapy in lung cancer -- Management of toxicities of targeted therapies -- Immunotherapy and lung cancer -- Adjuvant and neoadjuvant chemotherapy for early-stage nonsmall cell lung cancer -- Treatment of extensive-stage small cell lung cancer -- Malignant mesothelioma -- Mediastinal tumors -- Neuroendocrine tumors of the lung other than small cell lung cancer -- Thymic tumors -- Lung cancer emergencies -- The role of palliative care in lung cancer -- Clinical trial methodology in lung cancer : study design and end-point considerations -- How to promote and organize clinical research in lung cancer -- The role of advocacy groups in lung cancer -- The role of health services research in improving the outcomes for patients with lung cancer.

PREVENTION OF WHITE SPOT LESIONS (WSLs): Background: Incidence & Prevalence -- Detection -- Treatment -- Prevention -- Clinical Recommendations. MAINTENANCE OF PERIODONTAL HEALTH AND PREVENTION OF PERIODONTAL DETERIORATION: Extraction vs. non-extraction treatment -- Functional appliances vs. headgear -- Diagnosis and treatment of anterior open bite -- The importance of chin projection -- Stability and Post-treatment retention -- Clinical Recommendations. PREVENTION OF EXTERNAL APICAL ROOT RESORPTION (EARR): Etiologic Factors -- Controversies -- Genetic predisposition -- Evidence -- Root-Sparing Treatment Strategies -- Clinical recommendations.

Pt. 1. A-K -- Pt. 2. L-Z

v. 1. Diseases, tabular list -- v. 2. Diseases, alphabetic index.

Online version includes browsable tabular headings with search capability and instruction manual as well as links to older versions.

"ICD-10-CM is the United States' clinical modification of the World Health Organization's ICD-10. The term "clinical" is used to emphasize the modification's intent: to serve as a useful tool in the area of classification of morbidity data for indexing of health records, medical care review, and ambulatory and other health care programs, as well as for basic health statistics. To describe the clinical picture of the patient the codes must be more precise than those needed only for statistical groupings and trend analysis"--Preface

Medical and Surgical -- Obstetrics -- Placement -- Administration -- Measurement and Monitoring -- Extracorporeal or Systemic Assistance and Performance -- Extracorporeal or Systemic Therapies -- Osteopathic -- Other Procedures -- Chiropractic -- Imaging -- Nuclear Medicine -- Radiation Therapy -- Physical Rehabilitation and Diagnostic Audiology -- Mental Health -- substance Abuse Treatment -- New Technology -- Definitions -- Device Aggregation Table -- Index.

Part I Basis of ICG Fluorescence Method -- Chapter 1 Photodynamic Characteristics of ICG Fluorescence Imaging -- Chapter 2 Indocyanine Green Fluorescence Properties -- Chapter 3 Classical Signaling Pathways -- Chapter 4 Characteristics of the Photodynamic Eye Camera -- Part II Neurosurgery -- Chapter 5 ICG Video-Angiography in Neurosurgical Procedures -- Part III Head and Neck Surgery -- Chapter 6 ICG Fluorescent Image-Guided Surgery in Head and Neck Cancer -- Part IV Cardiovascular Surgery -- Chapter 7 An Innovative SPY Intraoperative Imaging and Validation Technologies for Coronary Artery Bypass Grafting -- Chapter 8 Application of an Angiographic Blood Flow Evaluation Technique in C ardiovascular Surgery Using the HyperEye Medical System -- Part V Sentinel Node Navigation Surgery and Other Applications for Gastrointestinal Tract Cancers -- Chapter 9 Principle and Development of ICG Method -- Chapter 10 Practice of Fluorescence Navigation Surgery Using Indocyanine Green for Sentinel Lymph Node Biopsy in Breast Cancer -- Chapter 11 A Perspective on Current Status and Future Directions of Sentinel Node Biopsy Using Fluorescence Imaging System in Breast Cancer -- Chapter 12 Indocyanine Green Fluorescence Axillary Reverse Mapping for Sentinel Node Navigation Surgery in Breast Cancer -- Chapter 13 A New Concept for Axillary Treatment of Primary Breast Cancer using Indocyanine Green Fluorescence Imaging -- Chapter 14 Function-Preserving Curative Gastrectomy Guided by ICG Fluorescence Imaging for Early Gastric Cancer -- Chapter 15 Fluorescent Navigation Surgery for Gastrointestinal Tract Cancers: Detection of Sentinel Nodes, Tumor Tattooing and Harvesting of Lymph Nodes -- Chapter 16 Sentinel Node Navigation Surgery for Rectal Cancer -- Indications for Lateral Pelvic Lymph Node Dissection -- Chapter 17 Indocyanine Green Fluorescence-Navigated Sentinel lymph node navigation surgery (SNNS) for skin cancers ( in cutaneous malignant melanoma and extramammary Paget's disease) -- Chapter 18 Regional Lymph Node Dissection Assisted by Indocyanine Green Fluorescence Lymphography and Angiography for Stage III Melanoma -- Part VI Assessment of Blood Supply toTissue & Reconstructed Organ with Application of Plastic Surgery -- Chapter 19 Blood Supply Visualization for Reconstruction During Esophagectomy -- Chapter 20 Evaluation of Viability of Reconstruction Organs During Esophageal Reconstruction -- Chapter 21 ICG Fluorescence Navigation Surgery in Breast Reconstruction with TRAM Flaps -- Chapter 22 Intraoperative Evaluation of Flap Circulation by ICG Fluorescence Angiography in the Breast Reconstruction with Pedicled TRAM Frap -- Chapter 23 Pre- and Intraoperative Identification of Perforator Vessels Using MRA/MDCTA, Doppler Sonography, and ICG Fluorescence Angiography -- Chapter 24 Intraoperative Assessment of Intestinal Perfusion Using Indocyanine Green Fluorescence Angiography (ICG-AG) During Pediatric Surgery -- Part VII Hepato-Pancreatic-Biliary Surgery -- Chapter 25 Basic Aspects of ICG Fluorescence Imaging of the Liver -- Chapter 26 Intraoperative Liver Segmentation Using Indocyanine Green Fluorescent Imaging -- Chapter 27 Liver Parenchymal Staining Using Fusion ICG Fluorescence Imaging -- Chapter 28 Anatomical Hepatectomy Using Indocyanine Green Fluorescent Imaging and Needle-Guiding Technique -- Chapter 29 Microscopic Findings of Fluorescence of Liver Cancers -- Chapter 30 Intraoperative Detection of Hepatocellular Carcinoma Using Indocyanine Green Fluorescence Imaging -- Chapter 31 Laparoscopic Intraoperative Identification of Liver Tumors by Fluorescence Imaging -- Chapter 32 Application of Indocyanine Green Fluorescence Imaging to Pediatric Hepatoblastoma Surgery -- Chapter 33 Indocyanine Green Related Transporters in Hepatocellular Carcinoma -- Chapter 34 Liver Transplantation guided by ICG-fluorescence imaging: assessment of hepatic vessel reconstruction -- Chapter 35 Fluorescence Imaging for Intraoperative Identification of Pancreatic leak -- Chapter 36 Intraoperative Indocyanine Green Fluorescent Imaging for Prevention of Bile Leakage after Hepatic Resection -- Chapter 37 ICG Fluorescence Cholangiography During Laparoscopic Cholecystectomy -- Chapter 38 Usefulness of ICG Fluorescence Imaging in Laparoscopic Liver resection -- Part VIII Surgery for Lymphedema -- Chapter 39 Detection of Hepatic Micrometastases from Pancreatic Cancer -- Chapter 40 Superficial Lymph Flow of the Upper Limbs Observed by an Indocyanine Green Fluorescence Method: Lymph Flow in Healthy Persons and Patients with Breast Cancer-Related Lymphedema -- Chapter 41 Indocyanine Green Fluorescent Lymphography and Microsurgical Lymphaticovenous Anastomosis -- Chapter 42 Comprehensive Lymphedema Evaluation Using Dynamic ICG Lymphography -- Chapter 43 Lymphatic Pumping Pressure in the Legs and Its Association with Aging, Edema, and Quality of Life -- Chapter 44 ICG Fluorescence Lymphography for Confirming Mid- to Long-Term Patency of Lymphatic Venous Side-to-End Anastomosis in the Treatment of Peripheral Lymphedema.

"Examining the implications and practical implementation of multi-disciplinary International Conference on Harmonization (ICH) topics, this book gives an integrated view of how the guidelines inform drug development strategic planning and decision-making. Addresses a consistent need for interpretation, training, and implementation examples of ICH guidelines via case studies. Offers a primary reference point for practitioners addressing the dual challenge of interpretation and practical implementation of ICH guidelines. Uses case studies to help readers understand and apply ICH guidelines. Provides valuable insights into guidelines development, with chapters by authors involved in generating or with experience implementing the guidelines. Includes coverage of stability testing, analytical method validation, impurities, biotechnology drugs and products, and good manufacturing practice (GMP)"-- Provided by publisher.

"Offering essential, evidence-based practice guidelines specifically for the critical care setting, ICU Quick Drug Guide contains up-to-date information in a quick-access format. This portable handbook provides fast, accurate drug therapy information needed at the point of care, including expert advice throughout to help clinicians determine optimal pharmacological therapy"--Publisher's description.

Part I: Contrasts in Global Health Care Resource Allocation -- Australia: Where Have We Been? -- Brazil: Where Have We Been? -- Canada: Where Have We Been? -- Germany: Where Have We Been? -- India: Where Have We Been? -- Israel: Where Have We Been? -- Italy: Where Have We Been? -- The Netherlands: Where Have We Been? -- New Zealand: Where Have We Been? -- South Africa: Where Have We Been? -- United Kingdom: Where Have We Been? -- United States-Private Practice: Where Have We Been? -- United States-Academic Medicine: Where Have We Been? -- Australia: Where Are We Going? -- Brazil: Where Are We Going? -- Canada: Where Are We Going? -- Germany: Where Are We Going? -- India: Where Are We Going? -- Italy: Where Are We Going? -- The Netherlands: Where Are We Going? -- New Zealand: Where Are We Going? -- South Africa: Where Are We Going? -- United Kingdom: Where Are We Going? -- United States-Private Practice: Where Are We Going? -- United States-Academic Medicine: Where Are We Going? -- Re fl ections on the Demand for Critical Care in the Global Medical Village -- First Critique of Buchman and Chalfin's Analysis -- Second Critique of Buchman and Chalfin's Analysis -- Third Critique of Buchman and Chalfin's Analysis -- Fourth Critique of Buchman and Chalfin's Analysis -- Part II: The Fair and Equitable Health Care Act -- The Fair and Equitable Health Care Act -- First Critique of the Fair and Equitable Health Care Act -- Fixing the Foundation of Critical Care at the End-Stage of Life: Second Critique of the Fair and Equitable Health Care Act -- Third Critique of the Fair and Equitable Health Care Act -- Part III: Legal and Nursing Viewpoints -- Medical Judgment Versus Capitulation -- Nursing Aspects of Inappropriate Patient Care -- Part IV: Conclusions -- Where Is "Universal" Health Care Headed in the Global Village? -- The New Shape of Intensive Care In the USA -- Health Care in the Year 2050.

This book provides step-by-step guidance on how to identify, assess and treat adults who have abused animals. The theoretical framework employed is broad, encompassing cognitive behavioral, psychodynamic, attachment, and trauma-based theories. Organized by stages of therapy, the text discusses how to frame the therapy, establish a working relationship, deal with resistance, establishing accountability, clarifying values related to animals, and teaching self-management skills such as empathy, attachment, accommodation, reciprocity and nurturance. Additional materials are included or referenced, including an appendix of cases that illustrate the variety of client presentations and electronic supplementary material demonstrates role-played interviews and a workshop presentation.

Identification and data-processing methods in metabolomics / Serge Rudaz -- Untargeted metabolomics: global in scope and potential / Ritvik Dubey, Dennis W. Hill & David F. Grant -- LC-MS data acquisition and validation in metabolomics / Damien L. Callahan -- From raw signals to identified metabolites: recent tools for enhancing LC-MS untargeted metabolomic data processing / David Tonoli, Fabienne Jeanneret, Julien Boccard & Serge Rudaz -- Identification of metabolites in LC-MS-based metabolomics / Yutai Li -- Traveling-wave ion mobility-mass spectrometry in metabolomics: workflows and bioinformatic tools / Giuseppe Paglia, Lochana Menikarachchi, James Langridge & Giuseppe Astarita -- Principal component analysis in metabolomics: from multidimensional data toward biologically relevant information / Renata Bujak & Michal Jan Markuszewski -- Machine learning algorithms for metabolomics applications / Serhiy Hnatyshyn, Umashanger Thayasivam, Vasil Hnatyshin & Curtis White -- Pathway and network analysis / Shuzhao Li -- Targeted metabolomics applied to the study of intracellular eukaryotic pathogen metabolism / Maria Belen Cassera -- Normalization and scaling effects on 1H NMR spectra in a metabolomics analysis of leukemic cells / Thomas Cruz, Julie Lalande, Stéphane Balayssac, Jérôme Kluza, Véronique Gilard, Philippe Marchetti & Myriam Malet-Martino -- Case study: urinary tract infection / Tiziana Pacchiarotta & Oleg A Mayboroda -- Potentiality of volatile organic compounds to discriminate patients with cancer by using chemometric tools / Márcia Sá Monteiro, Márcia Carvalho, Maria de Lourdes Bastos & Paula Guedes de Pinho.

The novel coronavirus 2019 (COVID-19) has caused a serious global pandemic in just one year. Nearly every country and territory in the world has been affected by the virus. The virulence and infection rate of the virus are profound, and has required extreme social distancing measures across the globe in order to prevent overwhelming the healthcare services and hospitals. COVID-19 appears to have the greatest effects on elderly individuals and those who have co-morbid diseases, such as diabetes and obesity. As the cases and death rate remain high, there are justified fears of this virus remaining for several months or years to come. To address this, a rapid and unprecedented worldwide mobilization effort has begun to identify effective treatments and develop vaccines. As these begin to be deployed and administered across the globe, many now feel the virus will be brought under control and lives will eventually return to normal. This new volume will increase readers understanding of the ongoing COVID-19 pandemic through a series of chapters that address these concerns. Leading experts will discuss new treatment approaches, vaccine development, mental health aspects of the pandemic, and convey the results of survey studies. The book will be an excellent resource for researchers studying virology, metabolic diseases, respiratory disorders, and clinical scientists, physicians, drug companies, and healthcare services and workers.

This book is a practical, compact guide for the identification of common tropical and subtropical ornamental plants by flower colour. It is intended for anyone who is interested in plants and would like to get to know the attractive flowering plants of warm regions while travelling. Certainly everyone in a foreign country has at some point admired a particularly exotic flower and wished to know which plant it is. With appealing photos and comprehensible texts, this book provides the answer - quickly and easily. The author is an experienced tour guide and is regularly asked for eye-catching, ornamental plants on the way. She photographed the frequently requested plants and arranged them according to colour in this nature guide. This book is also suitable for beginners without previous botanical knowledge due to its illustrations and simple sorting.

"This is a new and expanded edition of a classic case-study in the medicalization of ADHD, originally published in 1976. The book centres on an empirical study of the process of identifying hyperactive children, providing a perceptive and accessible introduction to the concepts and issues involved. In this revised edition, Peter Conrad sets the original study in context, demonstrating the continuing relevance of his research. He highlights the issues at stake, outlining recent changes in our understanding of ADHD and reviewing recent sociological research. Peter Conrad is Harry Coplan Professor of Social Sciences at Brandeis University, USA. He has written extensively in the area of medical sociology, publishing nine books and over eighty articles and chapters."--Provided by publisher.

In her study Elisabeth Salzer describes three novel monogenic diseases. For CD27 deficiency Elisabeth Salzer describes a large cohort of patients. Although all patients shared the same causative missense mutation, they displayed diverse clinical presentations. In another patient she was able to identify a mutation in PRKCD resulting in a primary immunodeficiency with severe Lupus-like autoimmunity. The patient exhibited increased mRNA levels of IL6. Therefore, treatment with Tocilizumab, a humanized anti-IL-6 receptor monoclonal antibody was suggested. In a family with a history of deaths due to inflammatory bowel disease she identified a missense mutation in IL21. She produced wild type and mutated IL-21 protein and demonstrated a loss of function phenotype. As IL-21 is in clinical trials, she proposed a potentially curative treatment option. These discoveries contributed to the understanding of the multifaceted regulatory mechanisms of the immune system and highlighted essential players in these complex signaling networks. Contents CD27 Deficiency-Description of a Large Patient Cohort PRKCD Deficiency with Lupus-Like Autoimmunity IL-21 Deficiency Results in Very Early-Onset Inflammatory Bowel Disease Target Groups Scientists and students in the field of pediatrics, immunology, gastroenterology, rheumatology and genetics Pediatricians About the Author Dr. Elisabeth Salzer works on the discovery and description of novel immunodeficiencies in children and adolescents at the CeMM Center for Molecular Medicine.

This book provides a valuable guide to understanding idiopathic intracranial hypertension (IIH), which is a very complex and painful disease. It is a chronic, often disabling condition resulting in headaches, visual loss, and ringing in the ears. This condition was thought to be rare but is becoming much more common, especially as the population becomes more overweight. Patients with this condition often suffer from intractable headaches with poor quality of life. Very few physicians specialize in this condition, and as a result, there is almost no information or resources available to those trying to understand this condition. The text is designed to take very complex neurosurgical anatomy, principles, and treatments and reduce them down into simple principles. The book contains 12 chapters, each organized into distinct sections. All chapters also contain key points from those paragraphs to summarize useful take home messages. Written by an expert specializing in this debilitating condition, Idiopathic Intracranial Hypertension Explained serves as a valuable guide towards understanding and treating IIH. The ultimate goal is to empower patients and families with knowledge about the disease.

Idiopathic Pulmonary Fibrosis: A Comprehensive Clinical Guide delivers a concise review of our current understanding of disease pathogenesis and provides current evidence in the medical literature regarding its diagnosis and management. Each chapter includes key points and a summary aiming to update clinicians about various issues concerning the diagnosis and management of IPF. In addition to outlining the current state of knowledge, each chapter also provides a summary of ongoing research and identifies the needs for future research in the field. Idiopathic Pulmonary Fibrosis: A Comprehensive Clinical Guide is an important new text that provides its readers with a better understanding of the pathobiology and natural history of IPF as it continues to evolve.

Intro; Preface; Contents; Contributors; Chapter 1: Classification and Nomenclature of Interstitial Lung Disease; Introduction; Current Approaches to the Classification of ILD; Idiopathic Interstitial Pneumonias; Differentiating IPF from Non-IPF ILD; Summary; References; Chapter 2: Idiopathic Pulmonary Fibrosis: The Epidemiology and Natural History of Disease; Introduction; The Epidemiology of IPF; Background; Prevalence, Incidence, and Secular Trends; Mortality Rates and Secular Trends; Risk Factors; Definitions and Limitations; Genetic Risk Factors; Cigarette Smoking; Occupational Exposures Metal DustsWood Dust; Agriculture (Farming and Livestock); Sand, Stone, and Silica; Miscellaneous Exposures; The Natural History of IPF; Background; Predicting Survival; Rate of Decline in FVC; The Underlying Cause of Death; Phenotypic Subgroups; Long-Term Survivors; Rapid Progression from Diagnosis; Stable Disease Followed by Accelerated Disease; Acute Exacerbations of IPF; Subclinical Disease; Specific Clinical Phenotypes of Disease; IPF with Pulmonary Hypertension; Combined Pulmonary Fibrosis and Emphysema; Summary; References; Chapter 3: Histopathology of IPF and Related Disorders IntroductionHistopathologic Classification of Idiopathic Interstitial Pneumonias; Usual Interstitial Pneumonia; Clinical Features; Pathologic Features; Desquamative Interstitial Pneumonia/Respiratory Bronchiolitis Interstitial Lung Disease; Clinical Features; Pathologic Features; Significance of Pathological Diagnoses of DIP or RBILD; Nonspecific Interstitial Pneumonia; Clinical Features; Pathologic Features; Pleuroparenchymal Fibroelastosis; Clinical Features; Pathologic Features; The Role of Surgical Lung Biopsy in Classification and Diagnosis of Idiopathic Interstitial Pneumonias "Pattern" Versus "Diagnosis" for Reporting the Results of Surgical Lung BiopsyDistinguishing Fibrotic NSIP from UIP; Role of Transbronchial Biopsies; Summary; References; Chapter 4: Imaging of Idiopathic Pulmonary Fibrosis; Introduction; Radiography; Technical Aspects of HRCT; Typical HRCT Pulmonary Findings; Accuracy of HRCT; Prognosis; Thoracic Complications of IPF; Atypical UIP on HRCT and How to Distinguish It from Other Common Fibrotic Lung Diseases; Summary; References; Chapter 5: Pulmonary Function Tests in Idiopathic Pulmonary Fibrosis; Pulmonary Function Tests in IPF FVC and DLco in Routine Clinical Practice and Clinical Trials: Strengths and PitfallsFuture Directions: Home Daily Spirometry in IPF; References; Chapter 6: The Role of Immunity and Inflammation in IPF Pathogenesis; Innate Immunity and Altered Host Defence Mechanisms; Chemotactic Cytokines; CXC Chemokines and Their Receptors; The Role of CXC Chemokines in Pulmonary Fibrosis; Vascular Remodelling in Pulmonary Fibrosis: The Role of CXC Chemokines; Macrophages; Neutrophils; Adaptive Immunity; Autoimmunity and IPF; Other Immunologically Active Cells; Inflammation and Acute Exacerbations of IPF

From epidemiology and pathogenesis to disease management, this book reviews our current understanding of and provides up-to-date information of Idiopathic Pulmonary Fibrosis (IPF). A subtype of Idiopathic Interstitial Pneumonias (IIP), IPF is one of the most elusive and intractable respiratory disease to date and its triggering factors remain unclear. However, new developments such as serum markers that are highly specific to IPF (i.e. KL-6, SP-A, and SP-D), the establishment of systematic diagnostic imaging (HRCT) and accumulated reports of treatment using an antifibrotic agent (pirfenidone) are slowly improving our understanding of the disease. Edited by an established authority in the field and written by experts, this book will be valuable to not only to beginning learners but also to physicians, instructors and researchers whose work involves IIPs. With each chapter exploring critical questions, with unresolved issues and future prospects, the book offers a valuable resource for understanding issues such as the newly proposed entity of interstitial pneumonia with emphysema (combined pulmonary fibrosis and emphysema: CPFE) and the mechanism of how so many IIP sufferers develop lung cancer.

The definitive practical reference on managing idiopathic scoliosis from world-renowned experts Idiopathic Scoliosis: The Harms Study Group Treatment Guide, Second Edition, edited by Peter O. Newton, Amer F. Samdani, Harry L. Shufflebarger, Randal R. Betz, and Jürgen Harms and written by an impressive group of experts reflects treatment advances made in the last decade. Greater understanding of the etiology and improved 3D anatomy has resulted in significant strides in clinical management of scoliosis. This richly illustrated book presents all facets of evaluation and treatment of abnormal cur.

Igapó forests are a common part of the Amazon whose ecosystems are critical to our shared human future. The introduction addresses the structure, function and dynamics of igapó forests in the Amazon basin, focusing on their uniqueness due to their high level of complexity defined as the many ways that different components of igapó forests in the Amazon basin ecosystem interact and also on how those interactions are on a higher-order compared to other tropical forests. The text then breaks down the igapó ecosystem using these sections: (1) Igapó forests over space and time, (2) Water, light and soils, (3) The carbon cycle, (4) Litter, fungi and invertebrates, (5) Vertebrates, (6) Plant population studies, (7) Plant community studies, and (8) Human impacts and management. Experts from around the world serve as chapter authors that review what is known about their specific part of the igapó ecosystem, what research they have done, and also what needs to be done in the future.

Biology of IgE production: IgE cell differentiation and the memory of IgE responses / Jin-Shu He, Sriram Narayanan, Sharrada Subramaniam, Wen Qi Ho, Juan J. Lafaille and Maria A. Curotto de Lafaille -- Molecular mechanisms of IgE class switch recombination / Pei Tong and Duane R. Wesemann -- Anti-IgE therapy: clinical utility and mechanistic insights / Stephanie L. Logsdon and Hans C. Oettgen -- New insights on the signaling and function of the high-affinity receptor for IgE / Ryo Suzuki, Jörg Scheffel and Juan Rivera -- Helminth-induced IgE and protection against allergic disorders / Firdaus Hamid, Abena S. Amoah, Ronald van Ree and Maria Yazdanbakhsh -- IgE immunotherapy against cancer / Lai Sum Leoh, Tracy R. Daniels-Wells and Manuel L. Penichet -- Index.

IgG4-related disease is a new systemic disease that has only recently been identified and characterized. However, most clinical practitioners are not yet familiar with it and thus are likely to misdiagnose it. The purpose of this book is to raise awareness of this disease and its diagnostic pitfalls. A wealth of radiological and histopathological images helps clinicians to understand its characteristics in various organs as well as their clinical and basic medical backgrounds. All of the authors are experts who have published numerous important papers in the field. This book will be useful to physicians in various disciplines such as gastroenterology, rheumatology, ophthalmology, otolaryngology, urology, hematology, and respiratory medicine, not only as a textbook but as an authoritative and comprehensive reference work as well.

"This volume focuses on IgG4-related disease (IgG4-RD), a novel clinical entity involving multiple organs and of unknown origin, associated with the abundant infiltration of IgG4-positive cells. It consists of nine chapters written by prominent experts in the field and discusses the disease concept, diagnosis and treatment, as well as recent findings on its pathogenesis and pathophysiology. As such, it offers an invaluable source of information for researchers and clinicians alike."--Cover.

This book offers a detailed review of the pathological and imaging features, diagnosis and treatment of IgG4-Related Kidney Disease (IgG4-RKD). IgG4-related disease (IgG4-RD), which is characterized by an elevated serum IgG4 level and infiltration of systemic organs by IgG4 positive plasma cells, is a newly recognized systemic disease. Diverse renal manifestations including specific tubulointerstitial nephritis, membranous nephropathy, and tumor-like urological diseases extending to the pelvis and urinary tract in IgG4-RD have been reported and are recently attracting attention as IgG4-RKD. In this book, leading researchers in the field present the latest insights into the broad spectrum of IgG4-RKD characteristics. In addition, they provide a detailed explanation of the pathology of IgG4-RKD including comparisons between the kidney and other affected organs, such as the lacrimal, salivary glands and pancreas in the histopathological section. IgG4-Related Kidney Disease will have a major impact on future immunological and nephrological studies and offers a useful resource not only for nephrologists but also general physicians and investigators in related fields.

The appearance and diversification of receptors for IgM during vertebrate evolution. -- Authentic IgM Fc Receptor (FcR) -- FCRLA -- A resident endoplasmic reticulum protein that associates with multiple immunoglobulin isotypes in B lineage cells -- Specific IgM and regulation of antibody responses -- Role of Natural IgM autoantibodies (IgM- NAA) and IgM anti-leucocyte antibodies (IgM-ALA) in regulating inflammation.

The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition "Th17 Cells: Role in Inflammation and Autoimmune Disease" in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naïve T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed.

This comprehensive, illustrated guide presents representative general surgery, including gastrointestinal tract, hepatobiliary and inguinal hernia. Surgery is generally based on the microanatomy; however, in practice surgery involves more dynamic and floating anatomy. In the last decade, the methods have been constantly improved, shedding new light on classical anatomical science. Laparoscopic is one such methodology. All illustrations presented in this book have been drawn by the author - a pioneering surgeon - and show real-world procedures. All the methods introduced are practical and have been refined based on the precise clinical and embryological anatomy. This unique book offers readers essential insights into efficient and high-integrity surgeries in abdominal region. As such, it is a valuable resource for all gastrointestinal surgeons.

"As a successful dentist requires manual dexterity along with knowledge, this book is written for both undergraduate and postgraduate dental students who find it difficult to carve and waxing up the anatomy of teeth. As most of the students who are beginners to dentistry might not be skillful, this book will help them learn the required skills as well as improve their manual dexterity. In dental technician courses, carving skills are helpful during the initial years of the syllabus for carving on wax blocks and plaster blocks, as well as the making of acrylic teeth and wax-up procedures. In later stages of the course, the skills would be useful in both preparing tooth morphology and adjustments for casting procedures. The carving skills for clinicians will help them in providing proper morphology to each tooth, especially in aesthetic procedures along with posterior restorative procedures. This book makes the challenging task of carving (in restorative procedures too) and waxing up teeth easy, with the help of illustrative diagrams in a stepwise manner. For undergraduates, it helps in instrumentation, preparing of wax for carving and technique to build up wax"-- Provided by publisher.

This book focuses on the morphology, exine ornamentation and the associated evolutionary trends of crabapple pollen and anatomical developmental patterns. To examine the genetic evolutionary patterns of crabapple pollen traits, we constructed an interval distribution function based on characteristic pollen parameters and used a binary trivariate data matrix (Xi Yi Zi) to reflect the exine ornamentation regularity of the pollen. Our findings should inform the taxonomic status of the genus Malus. Pollen electron micrographs from a total of 26 species and 81 cultivars of Malus were recorded in this book. All 107 figures and 642 scanned pollen images constitute primary data obtained by the authors. The images in this book are clear, three-dimensional, and aesthetically pleasing. They are accompanied with text descriptions and provided a method for the indication of the different types of information that can be expected. This book can provide a reference for scientific researchers, students, and teachers in tertiary institutions that are engaged in research concerning crabapple production.

This book was compiled by researchers of Chinese Academy of Forestry, Sichuan Agricultural University, Southwest Forestry University, Kunming University of Science and Technology, and Chinese Academy of Sciences. It has been the most comprehensive monograph about the bamboo resources in China until now. "Illustrated Flora of Bambusoideae in China" is composed of two volumes. Volume 1 contains prefaces written by Shougong Zhang and Dezhu Li and the foreword by the authors, and 28 chapters, i.e., Morphology of Bamboos, Geographical Distribution of Bambusoideae, Hardiness Zones of Bambusoideae in China, 16 genera of the tribe Bambusese (Bambusa, Bonia, Cephalostachyum, Dendrocalamopsis, Dendrocalamus, Gigantochloa, Guadua, Leptocanna, Lingnania, Melocalamus, Melocanna, Neomicrocalamus, Neosinocalamus, Pseudostachyum, Schizostachyum, Thyrsostachys), and 9 genera of the tribe Arundinarieae (Brachystachyum, Chimonobambusa, Hibanobambusa, Indosasa, Phyllostachys,Qiongzhuea, Semiarundinaria, Shibataea, Sinobambusa). Totally, 512 bamboo taxa are recorded in volume 1, including 4 hybrids, 119 forms, 38 varieties, and 351 species in 25 genera.

This book combines an exceptional wealth of precise, exquisite schematic drawings and high-quality images with clear explanatory text in order to provide readers with a crisp and clear understanding of all aspects of congenital heart disease, from diagnosis to treatment and from the fetus to the adult. In format the book appears similar to a large collection of case reports covering all types of congenital heart disease, including complex lesions such as single ventricle and atrial isomerism. For each lesion, the illustrations are placed before the text so that the reader can gain a quick and general overview before going into more detail. The contents are as practical and concise as possible. The intention is that, despite its size, the book will serve as a handy reference for cardiologists, surgeons, intensivists, obstetricians specializing in fetal sonography, nurses, trainees, students, researchers, and even patients and their families. This is a "must-have" bedside reference in the cardiac ward, the ICU, and the fetal sonography room and will even be valuable in outpatient clinics.

"It gives us great pleasure to present our book that addresses problems with respect to the teaching and learning of oral histology. The idea to write a book focussed on important details of oral histological features popped up around two years ago, when we felt there are many deficient areas in the present literature concerning the said topic. This book gives information about these features in a user-friendly format. It contains high-definition (HD) histological images of oral tissues with integrated text containing their introduction, key identifying histological features, and clinical significance. The textbook is intended for dental undergraduate and postgraduate students, license examination aspirants, and oral histology instructors. We strongly believe that the book will suit the needs of professionals in each of these disciplines. We would like to mention here that we do not wish the present book to be a substitution of more general textbooks in oral histology. It is our belief that a good dental practitioner not only needs strong clinical skills, but also a solid understanding of basic sciences. Consequently, our book should be considered as providing the first step of the ladder in learning oral histology. This book is aimed at encouraging students to pursue a more exhaustive appreciation of the subject. To counter technology needs and in-line with the digital age, a companion website for the book has also been developed"-- Provided by publisher.

Written in a simple point by point style for ease of use, this volume covers all aspects of pediatric surgery with emphasis on important points for diagnosis and management. Each chapter covers a topic with emphasis on the most common conditions in neonatal and general pediatric surgery. The text is well illustrated with clinical, operative, radiological, and histopathological color figures and illustrations. The book also presents some of the rare conditions encountered in pediatric surgery, as well as common pediatric urology conditions. An Illustrated Guide to Pediatric Surgery is a useful reference to pediatric surgeons, specialists, fellows and residents, as well as general surgeons, pediatricians, neonatologists, medical students and interns interested in pediatric surgery.

This book is vital for physicians caring for young patients with urological conditions, as a quick reference book that is easy to read and well-illustrated. An Illustrated Guide to Pediatric Urology is useful to general surgeons, pediatricians, pediatric surgeons, fellows, residents, general physicians and family physicians, medical students and nurses. .

This book is unique in that it provides the reader with the most up-to-date terminology used to describe the human nervous system (central and peripheral) and the related sensory organs, i.e., the Terminologia Neuroanatomica (TNA), the official terminology of the IFAA (International Federation of Associations of Anatomists). The book provides a succinct but detailed review of the neuroanatomical structures of the human body and will greatly benefit not only various specialists such as (neuro)anatomists, neurologists and neuroscientists, but also students taking neuroanatomy and neuroscience courses. The book offers a high yield, combined presentation of neuroanatomical illustrations and text and provides the reader a?one-stop source? for studying the intricacies of the human nervous system and its sensory organs. It includes an alphabetical list of official English terms and synonyms with the official Latin terms and synonyms from the TNA. With regard to the entries, the name of the item in standardized English is provided, followed by synonyms and the official TNA Latin term, Latin synonyms and eponyms, a short description and in many cases one or more illustrations. To facilitate the use of illustrations, certain entries such as the gyri or sulci of the cerebral cortex are presented together with extensive cross-references. Terms that form part of a certain structure (such as the amygdaloid body, the thalamus and the hypothalamus) are listed under the respective structure. Segments and branches of arteries are discussed under the main artery, for example the A1?A5 segments under the anterior cerebral artery. Most nerves can be found following their origin from the brachial, cervical and lumbosacral plexuses. However, the major nerves of the limbs are discussed separately, as are the cranial nerves. Nuclei can be found by their English name or under Nuclei by their eponym.

"This title is part of the Tips and Tricks series we are developing in the orthopaedic surgery list, based on Harborview's Illustrated Tips and Tricks in Fracture Surgery. That title is unique in its approach in that it doesn't offer a comprehensive review of surgical procedures, nor does it offer a comprehensive review of the knowledge-base underlying orthopaedic trauma and its management. Instead it offers the sort of wisdom attending surgeons pass on to residents or fellows about how to perform surgery. These tips and tricks are often highly technical and also often highly contextual: "in this type of patient, I tend to use approach X for these reasons, while in other types of patients I do it this other way..." Residents and fellows often take notes on this advice. These notes from the orthopaedic trauma fellows at Harborview served as the foundation for the first edition of the Harborview title. This format is thus an adjunct to comprehensive procedural references, not a competitor. It sits in a unique and mostly vacant market niche and represents the stream of knowledge that is sometimes evidence-based (and sometimes not) used to train surgeons. This knowledge stream often contains nuggets unique to particular to institutions. The success of the Harborview title attests to the value of this approach: ~4800 units sold to date, in what has traditionally been viewed as the highly overpublished area of orthopaedic trauma. This title will originate from the renowned orthopaedic surgery department at Mayo Clinic, Rochester. Dan Berry will oversee the hip content and Marc Pagnano, the current chair, will oversee the knee. Coverage will include total hip and knee arthroplasties, revision hip and knee arthroplasties, hip arthroscopy, hip resurfacing, osteotomies for the hip and knee, unicondylar knee replacement, and more. Currently in development: Hospital for Special Surgery's Illustrated Tips and Tricks in Foot and Ankle Surgery, Emory's Illustrated Tips and Tricks in Spine Surgery, Illustrated Tips and Tricks in Sports Medicine Surgery. Brad Henley is the series editor for this series. He has held numerous positions for AAOS in addition to his role at Harborview, and is very well-connected. As currently scoped, additional topics in the series would be: hand-wrist-elbow surgery, pediatric orthopaedics (with perhaps one volume on ped fxs and one on everything else). Because these titles will not present procedures step-by-step, the areas need to be fairly broad in order to generate enough tips and tricks for a 300-400 pp book"-- Provided by publisher

1. General toxicology -- 2. Disposition -- 3. Mechanism of toxicity -- 4. Target organ toxicity -- 5. Pesticides (agrochemicals) -- 6. Metals and micronutrients -- 7. Nonmetals and micronutrients -- 8. Solvents, vapors, and gases -- 9. Poisonous and venomous organisms -- 10. Poisonous foods and food poisonings -- 11. Poisonous plants -- 12. Drugs of use, dependence, and abuse -- 13. Radioactive materials -- 14. Environmental and ecotoxicology -- 15. Veterinary toxicology -- 16. Clinical toxicology -- 17. Brainstorming: toxicology question bank -- Index.

This book employs a wealth of high-quality illustrations to provide the reader with a detailed understanding of the anatomy and the histology of the cartilage, the etiology and the classification of the cartilage lesions, and the numerous techniques employed for cartilage repair. Detailed attention is devoted to healthy cartilage, to each stage in the degenerative process, and to the response of the cartilage to the treatment. Imaging of the damaged and the repaired cartilage, as well as the information on the biomechanics are provided in great detail. The chapters on the techniques cover a wide range of approaches: marrow stimulation techniques, osteochondral cylinder transfer techniques, first, second and third generation autologous chondrocyte implantation techniques, allografts, cell-based therapies, orthobiologic approaches, and the role of 3D printing. The chapters closes with a consideration of the success of rehabilitation devices and the long-term results of cartilage repair.The book will be invaluable for all general orthopaedic and arthroscopic surgeons seeking a deeper knowledge of cartilage science and will help to dispel the confusion that still surrounds the reparative treatment. The authors are recognized experts in the fields of cartilage histology, assessment, classification, and repair.

Part 1. Endocrine Surgery -- 1. Total Thyroidectomy and Thyroid Lobectomy -- 2. Central Neck Dissection -- 3. Modified Radical Neck Dissection -- 4. Parathyroidectomy -- 5. Open Adrenalectomy -- 6. Laparoscopic Adrenalectomy: Transperitoneal Approach -- 7. Laparoscopic Adrenalectomy: Retroperitoneal Approach -- Part 2. Breast Surgery -- 8. Breast Biopsy -- 9.Breast Conservation Surgery (Surgical Biopsy, Lumpectomy, Nipple Exploration, Partial Mastectomy -- 10. Mastectomy -- 11. Axillary Procedures for Breast Cancer -- Part 3. Esophageal and Gastric Surgery -- 12. Laparoscopic Antireflux Surgery -- 13. Laparoscopic Surgery for Para-esophageal Hernias -- 14. Minimally Invasive Treatment of Esophageal Achalasia -- 15. Laparoscopic Bariatric Surgery -- 16. Esophagectomy -- 17. Gastric and Duodenal Surgery -- Part 4 . Small Bowel and Appendix Surgery.- 18. Meckel's Diverticulum Resection -- 19. Small Bowel Resection -- 20. Laparoscopic Splenectomy -- 21. Appendectomy -- Part 5. Colorectal Surgery -- 22. Right Hemicolectomy -- 23. Sigmoid Colectomy -- 24. Low Anterior Resection and Abdominoperitoneal Resection -- 25. Stomas (Colostomy and Ileostomy) -- Part 6. Anorectal Surgery -- 26. Cryptoglandular Disease -- 27. Pilondial Disease -- 28. Anal Fissure -- 29. Hemorrhoids -- Part 7. Hernia Surgery -- 30. Lichtenstein Tens ion-Free Open Inguinal Hernia Repair -- 31. Laparascopic Inguinal Hernia Repair: Transabdominal Preperitoneal (TAPP) Approach -- 32. Laparoscopic Inguinal Hernia Repair Total Extraperitoneal (TEP) Approach -- 33. Open Umbilical Hernia Repair -- 34. Laparoscopic Ventral Hernia Repair -- 35. Open Retromuscular Ventral Hernia Repair -- Part 8. Hepatobiliary Surgery -- 36. Open Hepatic and Biliary Procedures -- 37. Minimally Invasive Liver and Biliary Procedures -- Part 9. Pancreatic Surgery -- 38. Pancreaticoduodenectomy (Whipple Procedure) -- 39. Distal Pancreatectomy -- 40. Surgical Treatment of Chronic Pancreatitis -- Part 10 . Office-based Procedures -- 41. Vascular Access for Hemodialysis -- 42. Drainage of Abcess -- 43. Biopsy of Skin Lesions -- 44. Excisional Biopsy of Dermal and Subcutaneous Lesions.

Part 1. Introduction -- 1. Introduction -- Part 2. Computerized Diagnosis for Cancer -- 2. Computer-Aided Detection of Lung Cancer -- 3. Computer-Aided Detection and Differentiation of Breast Cancer on Mammograms -- 4. Computer-Aided Differentiation for Pathology Images -- Part 3. Computer-Assisted Radiation Treatment Planning -- 5. Computer-Assisted Target Volume Determination -- 6. Computer-Assisted Treatment Planning Approaches for SBRT -- 7. Computer-Assisted Treatment Planning Approaches for Carbon-Ion Beam Therapy -- 8. Computer-Assisted Treatment Planning Approaches for IMRT -- Part 4. Image-Guided Patient Positioning 9. X-ray Image-Based Patient Positioning -- 10. Surface-Imaging-Based Patient Positioning in Radiation Therapy -- Part 5. Intelligent Radiation Treatment Approaches -- 11. Tumor Tracking Approach -- 12. Visualization of Dose Distributions for Photon Beam Radiation Therapy During Treatment -- Part 6. Computerized Prediction of Treatment Outcomes -- 14. Computerized Prediction of Treatment Outcomes and Radiomics Analysis.

Image-Guided Cancer Therapy: A Multidisciplinary Approach provides clinicians with in-depth coverage of the growing, dynamic field of interventional oncology. Combining the knowledge of expert editors and authors into one powerhouse reference, this book looks at tumor ablation, HIFU, embolic therapies, emerging technologies, and radiation therapy throughout the body (liver, bone, breast, gynecologic and prostate cancers, to name just a few), and includes discussion of different imaging modalities. In the words of Peter Mueller, MD, author of the books Foreword: The senior authors are all world renowned experts in interventional oncology, which is another example of the high quality authorship and experience that is brought to this book. The later chapters discuss therapies that are simply not covered in any other source. Everyone who is doing or wants to do ablation therapies and interventional oncology will face a time when they will be asked to use their expertise in less used and less investigated areas. There is nowhere else where the reader can get information on the prostate, breast, and gynecologic areas, and especially pediatrics. This book is an outstanding contribution to the literature and will become a must read for all physicians who are interested in Interventional Oncology.

This book showcases the latest digital skin imaging, optical/laser systems and advanced immunologic therapies including topics ranging from the basic dermatologic sciences to advanced microscopic and laser optics. The addition of radiologic breakthroughs serves as comprehensive source for the dermatologic community, helping them access sonographic, CT, MRI and nuclear medicine procedures refined for dermatologic and subcutaneous pathologies. In addition, it assists radiologists determine the appropriate imaging technologies for specific clinical dermal disorders. A detailed and up-to-date overview of image-guided treatments is provided. The initial chapters on benign and inflammatory diseases are precursors to advanced chapters on hidradenitis suppurativa and pigmented lesion analysis. A dedicated chapter on melanoma skin cancer and malignant melanoma is followed by updated concepts of melanoma treatment, including genetic markers and PET/CT to monitor therapeutic success. Further chapters address such topics as dermal trauma from foreign bodies and burns, scar imaging, fillers complications and podiatric imaging. Chapters on optical coherence tomography and reflectance confocal microscopy complete the coverage. All chapters were written by dermatologists trained in ultrasound diagnosis, interventional radiologists, dermatopathologists and specialists in advanced optical and microscopic dermatologic analysis, providing a reference guide to noninvasive diagnosis techniques and image guided minimally invasive treatment options. As such, Image Guided Dermatologic Treatments will be an invaluable asset for clinicians in medical and allied fields where dermatologic diagnosis using the least invasive option is required.

This book equips readers with detailed knowledge on the current status of image-guided radiotherapy with photons and particles and highlights issues that need to be addressed in order to further improve treatment outcomes. The opening chapters cover clinical and technical aspects of target volume definition using anatomic (computed tomography and magnetic resonance imaging; MRI) as well as functional (MRI and positron emission tomography) imaging. Up-to-date information is then provided on the full range of image-guided high-precision radiotherapy techniques, including IMRT/VMAT, stereotactic body radiation therapy, MR-guided linear accelerators, MR-guided brachytherapy, and particle therapy. The role of ultrasonography in image-guided radiotherapy is discussed, as are the available means for target volume demarcation and stabilization and adaptive radiation therapy. Finally, outcome evaluation is explored in depth, with a particular focus on the role of multimodality imaging in predicting tumor control and normal tissue toxicity. The authors are experts in different specialties and the book will be of high value for radiation oncologists, medical physicists, radiologists, nuclear medicine physicians, and radiation technicians.

"Completely revised to reflect recent, rapid changes in the field of interventional radiology (IR), Image-Guided Interventions, 3rd Edition, offers comprehensive, narrative coverage of vascular and nonvascular interventional imaging -- ideal for IR subspecialists as well as residents and fellows in IR. This award-winning title provides clear guidance from global experts, helping you formulate effective treatment strategies, communicate with patients, avoid complications, and put today's newest technology to work in your practice"--Publisher's description.

This book provides an up-to-date and comprehensive primer on image-guided interventions for cancer. Image-guided interventional oncology is gaining popularity as it is a minimally invasive and more precisely targeted approach that both proves more effective and results in fewer side effects. This book's aim is to provide a clinical guide to interventional oncology for the entire oncology team. Chapters are approached with the same interdisciplinary perspective that is used in the care itself, with each chapter written by an interventional radiologist with contributions from medical, surgical and/or radiation oncologists. Chapters cover the major cancers that can benefit from interventional oncology treatment (including lung, liver, kidney, and bone), as well as some of the physics and physiology behind these interventional modalities. This is an ideal guide for interventional radiologists, medical oncologists, surgical oncologists, radiation oncologists, as well as relevant trainees. .

This book is a comprehensive review of image guided interventions of the spine. Beginning with a chapter dedicated to the history of image guided spinal interventions, authors set the stage for the role these procedures have and will play in the field. Chapters cover the key procedures, techniques, and considerations to maximize effectiveness and patient care. Some major topics covered include: imaging osseo-ligamentous spine anatomy, percutaneous vertebroplasty, image guided tumor ablation, and vascular spine intervention. Additional features include high-quality illustrations with concise descriptions and clinical cases discussions. This is an ideal guide for interventional neuroradiologists, radiologists, pain management physicians, neurosurgeons, orthopedic spine surgeons, and related residents, fellows, and students wanting in depth information on image guided interventions of the spine.

Significant advances have been achieved in musculoskeletal injection procedures during the past two decades, supported by the rapid development of imaging technology and the resulting clear presentation of three-dimensional anatomy. However, these procedures require additional training and expertise not always provided in residency training programs. This comprehensive book covers diagnostic and therapeutic intra- and extra-articular injection procedures for all joints and musculoskeletal regions. Each procedure is explained step by step, with discussion of indications, anatomy, pre- and postprocedural medications, needles, radiological equipment (conventional X-ray, US, and, when appropriate, CT, PET-CT, and MRI), patient positioning, technique, and aftercare. Potential difficulties are identified and helpful tips and tricks, provided. The lucid text is supported by informative drawings, model photographs, and radiological images. This book will assist beginners in starting to carry out injections by providing clear, precise procedural instructions and guidance on equipment and medications. It is hoped that while using the book, the reader will gain confidence by feeling that the authors are standing alongside, ready to answer any question that may arise.

This book offers a detailed and up-to-date overview of image-guided diagnostics in COVID-19 lung disease. A range of image-guided CT and ultrasound procedures in different chest regions are described. For each procedure, the benefits of image guidance are presented and its specialized application explained in the adult (outpatient, triage and hospital setting) and the pediatric patient. Lung Ultrasound Image Guidance assesses this rapidly evolving disease in real time while CT scans may be precisely targeted. The editor provides his 50+ year experience of multidisciplinary chest imaging including battlefield experience to optimally combat this recent viral assault. Image-Guided Management will be a valuable guide and reference not only for radiologists and pulmonary practitioners, but also for imaging technicians and First Responders. The intense public interest in safety and prevention is covered in the chapters on protection and decontamination. A chapter addressing the multiplicity of organ damage is useful for cardiologists and internists given the long differential diagnosis of respiratory distress entities. The emergence of point of care ultrasound providing 24/7 diagnostic access into inflammatory processes of the lung heralds its ascendance to the top tier of acute care diagnostic tools.

1. Pre- and periprocedural planning and patient management for spine or rib biopsies -- 2. Anticoagulation management -- 3. Image-guided percutaneous spine and rib biopsy: tools and techniques -- 4. Cervical spine biopsy -- 5. Toracic spine biopsy -- 6. Lumbar spine biopsy -- 7. Sacral biopsy -- 8. Rib biopsy -- 9. Biopsy for spine infection -- 10. Spine infection mimics -- 11. Image-guided percutaneous spine and rib biopsy: pathology -- Erratum -- Index.

Image-Guided Prostate Cancer Treatments is a comprehensive reference and practical guide on the technology and application of ultrasound and MRI in the male pelvis, with special attention to the prostate. The book is organized into three main sections, the first of which is devoted to general aspects of imaging and image-guided treatments. The second section provides a systematic overview of the application of ultrasound and MRI to the diagnosis and treatment of diseases of the lower urinary tract. Performance of the ultrasound and MRI studies is explained, and the normal and abnormal pathological anatomy is reviewed. Correlation with the ultrasound in the same plane is provided to assist in understanding the MRI sequences. Biopsy and interventional procedures, ultrasound-MRI fusion techniques, and image-guided therapies, including focused ultrasound, photodynamic therapy, microwave and laser ablation, are all fully covered. The third section focuses on securing treatment effectiveness and the use of follow-up imaging to ensure therapeutic success and detect tumor recurrence at an early stage, which is vital given that prompt focal treatment of recurrence is very successful. Here, particular attention is paid to the role of Doppler ultrasound and DCE-MRI technologies. This book, containing a wealth of high-quality illustrations based on high-end equipment, will acquaint beginners with the basics of prostate ultrasound and MRI, while more advanced practitioners will learn new skills, means of avoiding pitfalls, and ways of effectively relating the imaging and image-guided treatments to the clinical situation.

"This atlas provides high-quality multiplanar and volumetric color-coded imaging techniques utilizing CT, MRI, or angiography, supplemented by cadaveric presentations and color drawings that best elucidate each specific anatomic region. Twenty-one chapters with concise text encompass thoracic wall, mediastinum, lung, vascular, and cardiac anatomy, providing readers with a virtual dissection experience. Many anatomical variants along with pathological examples are presented"-- Provided by publisher.

Section 1: Knee -- Section 2: Leg -- Section 3: Ankle -- Section 4: Foot -- Section 5: Angles and measurements -- Section 6: Normal variants -- Section 7: Needle placement for procedures.

"Normal imaging anatomy and variants, including diagnostic and surgical anatomy, are the cornerstones of radiologic knowledge. Imaging Anatomy: Text and Atlas Volume 2, Abdomen and Pelvis is the second in a series of four richly illustrated radiologic references edited by distinguished radiologist Farhood Saremi. The atlas is coedited by esteemed colleagues Damián Sánchez-Quintana, Hiro Kiyosue, Dakshesh B. Patel, Meng Law, and R. Shane Tubbs with contributions from an impressive cadre of international authors. Succinctly written text and superb images provide readers with a virtual, user-friendly dissection experience"-- Provided by publisher.

I: Brain and spine -- II: Head and neck -- III: Thorax -- IV: Abdomen -- V: Pelvis -- VI: Upper extremity -- VII: Lower extremity -- VIII: Obstetrics and developmental anatomy.

This book describes the features in structural imaging of the most important pediatric brain tumors with the aim of enabling radiologists to make the correct differential diagnosis and to provide the pediatric oncologist with all the imaging information relevant to further management. The opening chapter is devoted to the complex subject of pediatric trials at the national and international levels and the importance of staging for stratification, differential treatment, and outcome. A general imaging protocol for children with brain tumors is presented, and individual chapters then identify key points for the differential diagnosis and staging of posterior fossa tumors, low- and high-grade gliomas, germ cell tumors, and craniopharyngiomas. The relevance of aspects such as tumor site and age to diagnosis is explained, and pitfalls associated with meningeal dissemination and treatment-related complications mimicking recurrence are highlighted. The importance of ensuring comparability of follow-up by use of standard MR (or CT) imaging is emphasized. In drawing on the lessons gained both from pediatric trials and from the author's own experience, this book will be invaluable for all radiologists.

Imaging and Focal Therapy of Early Prostate Cancer evaluates the scientific evidence for the evolving trend to treat low to intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, focal therapy methods. Various ablative devices such as high intensity focused ultrasound, irreversible electroporation, photodynamic therapy, cryotherapy and laser ablation, among others, are discussed in regard to their strengths and limitations as a therapeutic modality. Emphasis is placed on tumor stage shift towards early stage disease with an increase in unilateral versus bilateral cancers validated by final pathology assessment of large prostatectomy series. Current and new approaches to image cancer foci within the prostate (3-Dimensional contrast-enhanced transrectal ultrasonography, multiparametric magnetic resonance image with spectroscopy, ETC) are presented along with biopsy techniques to map prostate cancer. Patient selection, treatment strategy, outcomes and safety concerns that may provide acceptable cancer control and improved quality of life for patients are all covered in detail. Written by experts in the field and lavishly illustrated with detailed line-art and photographs, Imaging and Focal Therapy of Early Prostate Cancer is a resourceful volume beneficial to practitioners specializing in the treatment and management of prostate cancer.

1. Introcution : historiographies of obstetrics -- 2. Diagnostic ultrasound before Thomas Brown -- 3. Ian Donald before ultrasound I : St. Thomas's Hospital and the Royal Air Force -- 4. Ian Donald before ultrasound II : Hammersmith and Glasgow -- 5. A-scope investigations in Glasgow -- 6. The First contact scanner -- 7. The Automatic scanner and the diasonograph -- 8. "Behind the Iron Curtain" : ultrasound and the fetus -- 9. Diffusion, controversy, and commodification -- 10. Ian Donald after ultrasound : contraception and abortion -- 11. Maternity and technology.

Aimed at practicing clinicians and radiologists, this volume provides up-to-date, detailed information on potentially severe urinary tract infections (UTIs), which frequently require intensive in-patient antibiotic therapy, percutaneous or surgical treatment. UTIs are the most prevalent infectious illness, and account for hundreds of thousands of emergency and hospital admissions yearly. Furthermore, UTIs are the most common (almost 40%) type of hospital-acquired infections, with bladder catheterisation being the key risk factor. According to the European Association of Urology guidelines, complicated urinary tract infections (C-UTIs) are those associated with structural or functional genitourinary abnormalities or with conditions that impair the host's defence mechanisms, leading to an increased risk of acquiring infection or therapy failure. Besides offering current perspectives from urologists, nephrologists, and specialists in infectious diseases, the book presents the techniques and highlights the role of ultrasound and contrast-enhanced ultrasound, nuclear medicine, multidetector computed tomography (CT) and magnetic resonance imaging (MRI) in providing comprehensive investigations of upper and lower tract UTIs, and of systemic infections from unknown sources. Cross-sectional imaging is currently recommended to confirm UTI, to assess severity and look for underlying treatable structural or functional abnormalities, in order to provide a consistent basis for a correct therapeutic choice. Furthermore, dedicated chapters illustrate the current status of UTI imaging in children and the expanding role and possibilities of interventional radiology in the treatment of severe urinary tract infections.

This book, edited by leading experts in radiology, nuclear medicine, and radiation oncology, offers a wide-ranging, state of the art overview of the specifics and the benefits of a multidisciplinary approach to the use of imaging in image-guided radiation treatments for different tumor types. The entire spectrum of the most important cancers treated by radiation are covered, including CNS, head and neck, lung, breast, gastrointestinal, genitourinary, and gynecological tumors. The opening sections of the book address background issues and a range of important technical aspects. Detailed information is then provided on the use of different imaging techniques for T staging and target volume delineation, response assessment, and follow-up in various parts of the body. The focus of the book ensures that it will be of interest for a multidisciplinary forum of readers comprising radiation oncologists, nuclear medicine physicians, radiologists and other medical professionals.

Although interest in pancreatic pathology is very high in the radiological and gastroenterological communities, it is still the case that less is known about pathology of the pancreas than about liver pathology, for example. Diagnosis depends on the structure of the pancreatic lesion, which can be directly visualized on US, CT or MR images. This atlas, which encompasses both the imaging and the pathology of pancreatic neoplasms, will therefore be invaluable in enabling radiologists and sonographers to understand the underlying pathology and in allowing pancreatic pathologists to understand the imaging translation. The emphasis in the atlas is very much on the pathological and imaging appearances, with most of the text concentrated at the beginning of the chapters. A comprehensive overview is provided of typical and atypical presentations and diverse aspects of common and uncommon pancreatic neoplasms, including ductal adenocarcinoma, neuroendocrine neoplasms, intraductal papillary mucinous neoplasms, cystic neoplasms, metastases and lymphoma.

The second edition of this atlas focuses on imaging methods and techniques, new diagnostic concepts and therapeutic approaches in management of pancreatic neoplasms. Although interest in pancreatic pathology is very high in the radiological and gastroenterological communities, less is known about it than about, for example, liver pathology. Diagnosis depends on the structure of the pancreatic lesion, which can be directly visualized in US, CT or MR images. The books focus is very much on the imaging and pathological appearances, with most of the text concentrated at the beginning of the book followed by images gallery. A comprehensive overview is provided of typical and atypical presentations and diverse aspects of common and rare pancreatic tumors, including ductal adenocarcinomas with dedicated chapter to ductal adenocarcinoma downstaging, neuroendocrine neoplasms, cystic pancreatic neoplasms and intraductal papillary mucinous neoplasms. The Verona Pancreas Centre, the first institute of its kind in Italy and one of very few in the world, pursues an interdisciplinary approach to treating the problems of this organ, focusing on the patient, on research, and on teaching. A dedicated center that can look back on 40 years of tradition, many of its respected specialists have made essential contributions in surgery, gastroenterology, oncology, pathology, and radiology. Given its scope, this atlas will be an invaluable asset, helping radiologists understand the underlying pathology and helping pancreatic pathologists understand the imaging translation.

Primary Culture and Live Imaging of Adult Neural Stem Cells and Their Progeny / Felipe Ortega, Benedikt Berninger, and Marcos R. Costa -- Labeling and Tracking of Human Mesenchymal Stem Cells Using Near-Infrared Technology / Marie-Therese Armentero, Patrizia Bossolasco, and Lidia Cova -- High Content Imaging and Analysis of Pluripotent Stem Cell-Derived Cardiomyocytes / Gábor Földes and Maxime Mioulane -- A High Content Imaging-Based Approach for Classifying Cellular Phenotypes / Joseph J. Kim, Sebastián L. Vega, and Prabhas V. Moghe -- Conversion of Primordial Germ Cells to Pluripotent Stem Cells: Methods for Cell Tracking and Culture Conditions / Go Nagamatsu and Toshio Suda -- Imaging and Tracking of Bone-Marrow-Derived Immune and Stem Cells / Youbo Zhao [and four others] -- Co-Visualization of Methylcytosine, Global DNA, and Protein Biomarkers for In Situ 3-D DNA Methylation Phenotyping of Stem Cells / Jian Tajbakhsh -- Noninvasive Imaging of Myocardial Blood Flow Recovery in Response to Stem Cell Intervention / HuaLei Zhang and Rong Zhou -- Live Imaging of Early Mouse Embryos Using Fluorescently Labeled Transgenic Mice / Takaya Abe, Shinichi Aizawa, and Toshihiko Fujimori -- Live Imaging, Identifying, and Tracking Single Cells in Complex Populations In Vivo and Ex Vivo / Minjung Kang [and four others] -- Quantitative Evaluation of Stem Cell Grafting in the Central Nervous System of Mice by In Vivo Bioluminescence Imaging and Postmortem Multicolor Histological Analysis / Kristien Reekmans [and eight others] -- Micro-CT Technique for Three Dimensional Visualization of Human Stem Cells / Andrea Farini [and four others] -- Noninvasive Multimodal Imaging of Stem Cell Transplants in the Brain Using Bioluminescence Imaging and Magnetic Resonance Imaging / Annette Tennstaedt [and three others] -- Magnetic Resonance Imaging and Tracking of Stem Cells / Hossein Nejadnik, Rostislav Castillo, and Heike E. Daldrup-Link -- Whole Body MRI and Fluorescent Microscopy for Detection of Stem Cells Labeled with Superparamagnetic Iron Oxide (SPIO) Nanoparticles and DiI Following Intramuscular and Systemic Delivery / Boris Odintsov, Ju Lan Chun, and Suzanne E. Berry -- Molecular Imaging and Tracking Stem Cells in Neurosciences / Toma Spiriev, Nora Sandu, and Bernhard Schaller -- Bioluminescence Imaging of Human Embryonic Stem Cells-Derived Endothelial Cells for Treatment of Myocardial Infarction / Weijun Su [and four others].

Basis of practice -- Lighting in the Operative Room: Current Technologies and Considerations -- Modalities for Intraoperative Imaging -- Fluorescents Probes -- Detectors for Intraoperative Molecular Imaging: From Probes to Scanners -- Isotopes and Procedural Imaging -- Radiologically Imageable Nanoparticles -- Flat Panel CT and the Future of OR imaging and Navigation -- Cerenkov Luminescence Imaging -- Organ Deformation and Navigation -- Clinical Milestones for Optical Imaging -- 3D in the Minimally Invasive Surgery (MIS) Operating Room: Cameras and Displays in the Evolution of MIS -- Molecular Tumor Marker Recognition: Nanotechnology for On-Line Diagnostics in the OR -- Ultra Small Fluorescent Silica Nanoparticles as Intraoperative Imaging Tools for Cancer Diagnosis and Treatment -- Image Processing Technologies for Motion Compensation -- Current Clinical Applications -- Near Infra-red Imaging in Robotic Surgery -- New Preoperative Images, Surgical Planning and Navigation -- New Generation Radiosurgery -- Breast Lesion Localization -- Intraoperative Breast Imaging and Image-Guided Treatment Modalities -- Sentinel Lymph Node Mapping: Current Practice and Future Developments -- Narrow Band Cystoscopy -- Fluorescence Imaging of Human Bile and Biliary Anatomy -- PET Guided Interventions from Diagnosis to Treatment.

Section 1. Fluorescent microscopy -- Methods for visualization of peptidoglycan biosynthesis -- Time-lapse microscopy and image analysis of Escherichia coli cells in mother machines -- Microfluidics for bacterial imaging -- Section 2. Electron microscopy -- Electron cryotomography.

This is the first book to cover all aspects of the development of imaging biomarkers and their integration into clinical practice, from the conceptual basis through to the technical aspects that need to be considered in order to ensure that medical imaging can serve as a powerful quantification instrument capable of providing valuable information on organ and tissue properties. The process of imaging biomarker development is considered step by step, covering proof of concept, proof of mechanism, image acquisition, image preparation, imaging biomarker analysis and measurement, detection of measurement biases (proof of principle), proof of efficacy and effectiveness, and reporting of results. Sources of uncertainty in the accuracy and precision of measurements and pearls and pitfalls in gold standards and biological correlation are discussed. In addition, practical use cases are included on imaging biomarker implementation in brain, oncologic, cardiovascular, musculoskeletal, and abdominal diseases. The authors are a multidisciplinary team of expert radiologists and engineers, and the book will be of value to all with an interest in the quantitative imaging of biomarkers in personalized medicine.

"Epilepsy is a prevalent and serious neurological disorder. This vital textbook addresses the role of neuroimaging as a unique tool to provide in vivo biomarkers aimed at furthering our understanding of causes and consequences of epilepsy in a day-to-day clinical context. Unique in its approach, this translational book presents a critical appraisal of advanced pre-clinical biomarkers that allows capturing epileptogenesis at molecular, cellular, and neuronal system levels. The book is divided into four sections. Part I includes a series of chapters focused on imaging of early disease stages. Part II discusses lesion detection and network analysis methods. Part III focuses on imaging methods used to predict response to antiepileptic drugs and surgery. Finally, Part IV presents imaging techniques used to evaluate disease consequence"--Provided by publisher.

This book illustrates common diseases affecting the human nervous system using different imaging modalities derived from radiology, nuclear medicine, and neuropathology.

The scalp and cortex lie like pages of an open book on which the cortex enciphers vast quantities of information and knowledge. They are recorded and analyzed as temporal and spatial patterns in the electroencephalogram and electrocorticogram. This book describes basic tools and concepts needed to measure and decipher the patterns extracted from the EEG and ECoG. This book emphasizes the need for single trial analysis using new methods and paradigms, as well as large, high-density spatial arrays of electrodes for pattern sampling. The deciphered patterns reveal neural mechanisms by which brains process sensory information into percepts and concepts. It describes the brain as a thermodynamic system that uses chemical energy to construct knowledge. The results are intended for use in the search for the neural correlates of intention, attention, perception and learning; in the design of human brain-computer interfaces enabling mental control of machines; and in exploring and explaining the physicochemical foundation of biological intelligence.

Introduction -- Part I: Complications of upper digestive endoscopy -- Complications of upper digestive endoscopy -- Imaging techniques, expected post procedural appearances, and complications after upper digestive endoscopy -- Imaging complications of esophageal and gastroduodenal stents -- Part II: Complications of percutaneous endoscopic gastrostomy -- Complications of percutaneous endoscopic gastrostomy (PEG) -- Imaging techniques, expected post-PEG appearances and PEG-related complications -- Part III: Complications of endoscopic retrograde cholangiopancreatography and endoscopic biliopancreatic interventions -- Complications of diagnostic and therapeutic endoscopic retrograde cholangiopancreatography (ERCP) -- Imaging techniques and expected post-ERCP appearances -- Imaging findings of post-ERCP complications -- Section IV: Complications of colonoscopy and colorectal interventional procedures -- Complications of diagnostic and therapeutic colonoscopy -- Imaging techniques and expected post-colonoscopy appearances -- Imaging appearances of post-colonoscopy complications -- Endoscopic perforations in inflammatory bowel diseases -- Imaging complications of colorectal stents -- Imaging complications of anorectal endoscopic procedures -- Part V: Miscellanous topics -- Complications of small bowel capsule endoscopy -- Interventional radiology in the treatment of complications after digestive and biliopancreatic endoscopy.

Clinical anatomy of the coronary circulation -- Basic techniques in the acquisition of cardiac images with CT -- Examination of the coronary arteries -- Image reconstruction -- Coronary pathophysiology -- Clinical classification of coronary artery disease : who should be treated? -- Intravascular ultrasound : from gray-scale to virtual histology -- Identification and characterization of the atherosclerotic plaque using coronary CT angiography -- Coronary CT angiography : evaluation of stenosis and occlusion -- Current strategies in cardiac surgery -- Coronary CT angiography : evaluation of coronary artery bypass grafts -- Coronary stents -- CT angiography of coronary stents -- X-ray exposure in coronary CT angiography -- Optical coherence tomography in the cathlab -- Triple rule out : the use of cardiac CT in the emergency room -- Contraindications to coronary CT angiography -- Prognostic value of coronary CT -- Clinical cases.

This book presents a comprehensive overview of the major approaches to the imaging of the coronary arteries. These modalities, which include traditional angiography as well as intravascular and non-invasive imaging techniques, are used to diagnose and quantify the extent of obstructive disease due to atherosclerosis. Featuring contributions from leading authorities in the field, Imaging Coronary Atherosclerosis describes the visualization of coronary atherosclerosis through state-of the art techniques such as intravascular ultrasound, coronary near-infrared spectroscopy, computed tomography angiography, magnetic resonance imaging, and molecular imaging. This authoritative resource discusses how these modalities enhance the understanding of the disease process and the ways in which cardiologists can integrate them into clinical practice.

This book helps physicians select from among the currently available imaging tools, promoting the correct and cost-saving diagnosis and management of common dementias. Magnetic resonance (MR) and nuclear medicine techniques are routinely used to facilitate diagnosis, select therapies, provide information regarding the prognosis, and monitor therapy response in patients with cognitive impairment and dementia. Furthermore, the advent of quantitative MR techniques, such as diffusion-weighted imaging, perfusion imaging, etc. have opened up new opportunities to diagnose neurological diseases based on objective findings, and offer unique new insights into the main neurodegenerative diseases of the human brain. However, the practical value of various neuroimaging techniques in clinical practice has yet to be clearly defined, and their potential for future development is not yet fully appreciated. To help remedy the situation, this book offers practical and useful algorithms and rules that can be directly applied in the clinical setting. It provides concise content, together with a wealth of clinical case material.

This book provides a comprehensive, state-of-the-art overview of imaging modalities used in the diagnosis, staging, and management of pancreatic cancer. In addition to profiling the most commonly-used imaging modalities for pancreatic cancer, the text reviews recent advances in endoscopic ultrasound, staging characteristics utilized in determining appropriate treatment options, and reviews the role of imaging in pancreatic cancer screening in specialized patient populations. The book also spotlights the use of radiation therapy for pancreatic cancer in patients who cannot have surgery, as well as when fiducial marker placement should be considered in targeting a malignancy. Written by experts in the field, Imaging Diagnostics in Pancreatic Cancer: A Clinical Guide is a valuable resource for gastroenterologists, surgeons, oncologists, radiologists, and other practitioners who manage patients with pancreatic cancer.

"Imaging for the Health Care Practitioner offers authoritative, engagingly written coverage of common imaging modalities and their use in evaluating, monitoring, and treating the injuries most often encountered by health care professionals. The concise, clinically focused content focuses on what is most important to patient management and education. You will find a complete review of radiography, CT, MRI, and ultrasound, along with more than 360 state-of-the-art images that depict injuries and the healing process. The authors take you through both advantages and limitations of each modality in the rehabilitation setting as well as the screening and evaluation process. Armed with the expert insights found within this book, you will gain a meaningful frame of reference from which to discuss the results of these tests with patients."--Back cover.

As imaging technologies and approaches have evolved, the scope of certain imaging techniques has moved far beyond the production of purely illustrative images or appealing time-lapse movies to providing the scientist with a rich range of ways to measure and quantify the biological process and outcome of gene expression. In Imaging Gene Expression: Methods and Protocols, expert authors offer up-to-date approaches and protocols that scientists in the field have developed, which would benefit the broader scientific community. Divided in three convenient parts, this detailed book covers the output of a gene, namely the RNA molecules that are transcribed from the gene and the way by which these molecules can be tracked or quantified in fixed or living cells, protocols that focus on the gene, DNA, or chromatin, as well as a variety of ways by which nuclear processes intertwined with gene expression can be followed and quantified in living cells as well as approaches for studying several sub-nuclear structures found in eukaryotic cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective subjects, lists of materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Imaging Gene Expression: Methods and Protocols will serve researchers working toward imaging in the context of complete organisms.

This atlas is a detailed guide to the imaging appearances of gliomas following treatment with neurosurgery, radiation therapy and chemotherapy. It features more than 40 clinical cases and 500 illustrations, making it an invaluable clinical and research tool.

Part I. Introduction to oncologic imaging -- Part II. Bone and soft tissue tumors -- Part III. CNS tumors -- Part IV. Lung cancer -- Part V. Head and neck cancer -- Part VI. Lymphomas -- Part VII. Gynecologic cancer -- Part VIII. Breast cancer -- Part IX. Gastrointestinal cancer -- Part X. Neuroendocrine tumors -- Part XI. Urogenital cancer -- Part XII. Melanoma.

Designed to promote teamwork between radiologists and clinical oncologists, this book covers the currently available imaging modalities of relevance in clinical oncology. Discusses and illustrates a broad spectrum of oncologic diseases on these modalities.

Sonography of normal and abnormal thyroid and parathyroid glands / Andrioli, M.; Valcavi R. -- Computed tomography and magnetic resonance imaging of the thyroid and parathyroid glands / Warren Frunzac, R.; Richards, M. -- Role of nuclear medicine in the diagnosis of benign thyroid diseases / Garberoglio, S.; Testori, O. -- Hybrid molecular imaging in differentiated thyroid carcinoma / Schmidt, D.; Kuwert, T. -- Endoscopic ultrasound in endocrinology : imaging of the adrenals and the endocrine pancreas / Kann, P.H. -- Adrenal imaging : magnetic resonance imaging and computed tomography / McCarthy, C.J.; McDermott, S.; Blake, M.A. -- Adrenal molecular imaging / Sundin, A. -- Gonadal imaging in endocrine disorders / Lanfranco, F.; Motta, G. -- Magnetic resonance imaging of pituitary tumors / Boneville, J.-F. -- Intraoperative magnetic resonance imaging for pituitary adenomas / Buchfelder, M.; Schlaffer, S.-M. -- Molecular imaging of pituitary pathology / de Herder, W.W. -- Imaging of neuroendocrine tumors / Öberg, K.; Sundin, A.

Thyroid -- Pituitary gland -- Adrenal gland -- Endocrine pancreas -- Bone and mineral metabolism -- Gonads.

This book is a wide-ranging guide to current and emerging applications of ultrasonography within nephrology that aims to provide readers with a sound understanding of the rationale for and the use of ultrasound techniques in various disease settings, including, for example, complications following renal transplantation, arteriovenous fistulas, renal artery stenosis, nonstenotic renal artery pathology, renal vein pathology, aortic disease, and acute renal failure. Particular emphasis is placed on newer applications, such as those involving elastosonography, contrast-enhanced ultrasonography, and color Doppler imaging. There is no doubt that ultrasound techniques can improve the standard of care in nephrology, from vascular access planning to management of uremic complications. Nevertheless, many nephrologists continue to delegate the performance of ultrasonography to radiologists or other colleagues, which is especially regrettable given the advent of affordable, portable ultrasound scanners. This book will be of value for all clinicians interested in the role of ultrasound techniques in nephrology and will be especially useful for nephrologists seeking to incorporate ultrasonography into their practice. .

Written by two renowned leaders in neuroradiology and neurology, this unique reference is a high-level imaging resource ideal for today's clinical neurologist or neuroscientist. Using straightforward, jargon-free prose, this book provides an overview of neurological disorders coupled with typical imaging findings - all designed for use at the point of care. You will be expertly guided throughout, from radiologic appearance and the significance of the imaging findings to the next appropriate steps in effective patient care"--Publisher's description.

Unique case-based reference presents high-yield images and expertise focused on vascular neuroradiology. Imaging in Neurovascular Disease: A Case-Based Approach by Waleed Brinjikji and Timo Krings is unique in its approach, detailing diagnostic and interventional neuroradiology cases based on radiologic findings. The book explores the key role vascular imaging can play in treatment decision making, prognostication, and improving the understanding of the pathophysiology of neurovascular diseases.Spread over 11 chapters, this book covers a full spectrum of neurovascular diseases spanning the age continuum, starting with acute ischemic stroke, concluding with spinal vascular disease. All vascular neuroradiology cases follow a consistent format. After a succinct introduction describing the clinical scenario with relevant case images, the authors present key facts about the disease and the integral role of different neurovascular imaging procedures in disease management. Imaging findings are discussed in depth, with insightful clinical pearls on image-guided procedures and tips on managing potential pitfalls.

This volume addresses a wide range of issues in the field of nuclear medicine imaging, with an emphasis on the latest research findings. Initial chapters set the scene by considering the role of imaging in nuclear medicine from the medical perspective and discussing the implications of novel agents and applications for imaging. The physics at the basis of the most modern imaging systems is described, and the reader is introduced to the latest advances in image reconstruction and noise correction. Various novel concepts are then discussed, including those developed within the framework of the EURATOM FP7 MADEIRA research project on the optimization of imaging procedures in order to permit a reduction in the radiation dose to healthy tissues. Advances in quality control and quality assurance are covered, and the book concludes by listing rules of thumb for imaging that will be of use to both beginners and experienced researchers.

I: Suprahyoid and infrahyoid neck -- II: Squamous cell carcinoma -- III: Pediatric and syndromic diseases -- IV: Sinonasal cavities and orbit -- V: Skull base -- VI: Temporal bone and CPA-IAC.

This book is a comprehensive guide to dentomaxillofacial imaging in paediatric dentistry and is an excellent resource for both general dental practitioners and paediatric dentists. Radiation protection, radiation doses and potential risks of ionising radiation are discussed, to provide dentists with appropriate information when they are asked about these important issues in their practice. Technical information about X-ray machines, ranging from the intraoral machine to the medical computed tomography machine, as well as the differences between digital image detectors, are explained to the extend a (paediatric) dentist should know. The latter is important to understand why certain exposure settings are used and what the advantages or disadvantages are of the machines and the image detectors. Non-ionising radiation techniques, magnetic resonance imaging and ultrasonography, are also explained, as well are their applications in the field of dentomaxillofacial radiology. Knowing which imaging technique will provide the best diagnostic images possible, is key to every clinical case a dentist is faced with. A wide range of clinical examples are displayed in this book, ranging from incidental findings to malignant pathology. All are illustrated with radiographic material and explained, in order to give the reader a good sense of what to look for when assessing radiographs in the dentomaxillofacial field.

This book, co-authored by an internationally acclaimed team of experts in the field of pediatric oncologic imaging, provides a comprehensive update on new advances in diagnostic imaging as they relate to pediatric oncology. In contrast to other oncologic imaging texts focusing on the radiology of specific tumors, this book emphasizes the important fundamentals of imaging that every child with a new or treated malignancy receives. Guidance is provided on the selection and use of appropriate imaging techniques, with individual chapters devoted to each of the major cross-sectional imaging modalities used in the detection and follow-up of pediatric cancers, including PET-CT, PET-MRI, whole-body MRI, and diffusion-weighted MRI. Additional nuclear medicine techniques are addressed, and detailed attention is paid to more advanced areas of practice such as contrast-enhanced ultrasound, pediatric interventional radiology techniques, radiation treatment planning, and radiation dose considerations (ALARA). Other areas covered include screening of children with cancer predisposition syndromes, treatment related complications, potential pitfalls during neuro-oncologic imaging, and the risks and benefits inherent in post-therapy surveillance imaging.

This fully updated second edition is a definitive guide to imaging and differential diagnosis for pediatric pulmonary diseases and disorders. This edition is fully updated to include coverage of the latest imaging and diagnostic techniques, modalities, and best practices. Beginning with clinical algorithms, chapters provide a framework for clinical diagnosis. This image-based text presents a comprehensive, multi-modality approach, with an emphasis on plain film and cross-sectional imaging. The imaging sections, including a new chapter on pediatric thoracic MRI, are correlated with pathology and clinical findings to help readers learn what the modality of choice can enable them to see. This information and guidance is applied directly to diseases and disorders seen in everyday practice, including pleural effusion, focal lung disorders, pulmonary hypertension, cystic fibrosis, and asthma, as well as a new chapter on pediatric pulmonary embolism. In addition, a new chapter on the genetics of pediatric lung disorders has been added. This essential guide gives pediatric pulmonologists and radiologists the information to identify the differentials by symptom complex, accordingly determine what test would be effective, how to proceed, and to essentially provide the best care for their patients.

Every page crafted by a collaborative team of pediatricians and pediatric radiologists, this unique title by Drs. A. Carlson Merrow, Jr. and Selena Hariharan is a practical, superbly illustrated reference designed specifically for today's pediatrician. An ideal roadmap to the fast-changing landscape of diagnostic imaging tests, Imaging in Pediatrics not only guides you through the radiologic work-up of common pediatric disorders, but also translates the appearance and language of the work-up results for more effective communication between the pediatrician and the radiologist, resulting in enhanced understanding and better patient care. ... Includes an imaging glossary, introductory prose chapters with general guidelines on imaging specific organ systems, and numerous illustrations depicting complex anatomic and pathologic relationships of individual entities. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.

Looking out the optical window : physical principles and instrumentation of imaging in photodynamic therapy / Hui Liu and Jonathan P. Celli -- Photochemistry and photophysics of PDT and photosensitizers / Marcin Ptaszek -- Phthalocyanines in photodynamic therapy / Heidi Abrahamse -- Singlet oxygen luminescence imaging : a prospective tool in bioscience? / Michael Pfitznera, Jan C. Schlothauera, Buhong Lib, and Beate Röder -- Microbial biofilms and antimicrobial photodynamic therapy / Anil Kishen -- High-content imaging for photosensitizer screening / Gisela M.F. Vaz, Mathias O. Senge, Sarah-Louise Ryan, and Anthony Davies -- Enhanced efficacy of photodynamic therapy (PDT) via an iron-lysosome-mitochondria connection : studies with phthalocyanine 4 / Anna-Liisa Nieminen, Hsin-I Hung, and John J. Lemasters -- Role of cell death pathways in response to photodynamic therapy in gliomas / Leonardo Barcelos de Paula, Fernando Lucas Primo, and Antonio Claudio Tedesco -- In the search of specific PDT photosensitizers : subcellular localization and cell death pathways / Tayana M. Tsubonea, Christiane Pavanib, Isabel O.L. Bacellara, and Maurício S. Baptistaa -- Quantum dots in PDT / Ricardas Rotomskis and Giedre Streckytea -- MRI : PDT theranostics tetrapyrrole-based theranostic combinations of photodynamic action and magnetic resonance imaging / Duygu Aydin Tekdas, Devrim Atilla, Vefa Ahsen, and Ayse Gül Gürek -- Theranostic applications of photodynamic molecular beacons / Wentao Song, Yang Zhou, and Jonathan F. Lovell -- Tumor specific imaging and photodynamic therapy targeting the urokinase receptor / Zafar Iqbal, Longguang Jiang, Zhuo Chen, Cai Yuan, Rui Li, Ke Zheng, Xiaolei Zhou, Jjincan Chen, Ping Hu, and Mingdong Huang -- Vascular imaging in photodynamic therapy / Bin Chen -- Photosensitizer activity imaging on the microscopic scale / Steffen Hackbarth -- Bioluminescence imaging for monitoring the effectiveness of photodynamic therapy for infections in animal models / Pawel Mroz and Michael R Hamblin -- Imaging of photosensitizers in skin / Marica B. Ericson, Danni Wang, Despina Kantere, John Paoli, and Ann-Marie Wennberg -- Brain tumor imaging with ALA / Herbert Stepp and Oliver Schnell -- PDT of non-muscle-invasive bladder cancer with hexylester aminolevulinate : optimization of the illumination wavelengths by fluorescence spectroscopy and imaging / Matthieu Zellweger, Claude-André Porret, Norbert Lange, Patrice Jichlinski, Hubert van den Bergh and Georges Wagnières -- Endoscopic imaging and photodynamic therapy / Harubumi Kato, Kinya Furukawa, Jitsuo Usuda, Kuniharu Miyajima and Keishi Ohtani -- Spectroscopic imaging in prostate PDT / Rozhin Penjweini, Brian C. Wilson, and Timothy C. Zhu -- Fluorescent-guided resection in clinical oncology / Ron R. Allison.

Part I. Clinical, pathologic, and imaging evaluation of the arthritides and arthropathies -- Part II. The most common arthritides and arthropathies -- Part III. Articular and periarticular abnormalities that may masquerade as arthritis.

Imaging in Spine Surgery tailors the highly regarded Diagnostic Imaging series templates with radiology images and color graphics to the needs of neurosurgeons, orthopedic spine surgeons, pain management and rehab (PM&R) physicians, and anesthesiologists. It provides clinical information for diagnosis and appropriate care for the patient, resulting in the perfect comprehensive text for spine surgeons.

What the clinician wants to know:Upper extremity -- What the clinician wants to know: Lower extremity -- Role of MRI in sport medicine -- Role of ultrasound in sport medicine -- Injuries in American football -- Injuries in Basketball -- Injuries in Handball -- Injuries in Football (Soccer) -- Injuries in Rugby -- Injuries in Baseball injuries -- Injuries in Rock Climbing -- Injuries in high altitude mountaineering -- Injuries in Golf and Racquet -- Injuries in Snow skiing and snowboarding -- Injuries in Water sports -- Injuries in Rowing/wild water canoeing -- Injuries in Cycling -- Injuries in Tennis -- Injuries in Gymnasts -- Injuries in Triathlon -- Injuries in weightlifting -- Injuries in Track and field -- Injuries in Ice hockey -- Injuries in Ballet dancing -- Injuries in Volleyball.

Machine generated contents note: SECTION 1 OVERVIEW AND INTRODUCTION -- Imaging Approaches / Mitchell Tublin -- SECTION 2 RETROPERITONEUM -- Introduction to the Retroperitoneum / Matthew T. Heller -- Congenital -- Duplications and Anomalies of IVC / Matthew T. Heller -- Inflammation -- Retroperitoneal Fibrosis / Matthew T. Heller -- Degenerative -- Pelvic Lipomatosis / Matthew T. Heller -- Treatment Related -- Coagulopathic (Retroperitoneal) Hemorrhage / Matthew T. Heller -- Postoperative Lymphocele / Matthew T. Heller -- Benign Neoplasms -- Retroperitoneal Neurogenic Tumor / Matthew T. Heller -- Malignant Neoplasms -- Retroperitoneal Sarcoma / Michael P. Federle -- Retroperitoneal and Mesenteric Lymphoma / Matthew T. Heller -- Retroperitoneal Metastases / Matthew T. Heller -- Hemangiopericytoma / Matthew T. Heller -- Perivascular Epithelioid Cell Tumor (PEComa) / Matthew T. Heller -- SECTION 3 ADRENAL -- Introduction to the Adrenals / Michael P. Federle Note continued: Metabolic Or Inherited -- Adrenal Hyperplasia / Michael P. Federle -- Adrenal Insufficiency / Michael P. Federle -- Trauma -- Neonatal Adrenal Hemorrhage / Sara M. O'Hara -- Adrenal Hemorrhage / Michael P. Federle -- Benign Neoplasms -- Adrenal Cyst / Mitchell Tublin -- Adrenal Adenoma / Mitchell Tublin -- Adrenal Myelolipoma / Michael P. Federle -- Pheochromocytoma / Mitchell Tublin -- Malignant Neoplasms -- Neuroblastoma, Adrenal/Retroperitoneal / A. Carlson Merrow, Jr. -- Adrenal Carcinoma / Michael P. Federle -- Adrenal Carcinoma Staging / Marta Heilbrun -- Adrenal Lymphoma / Mitchell Tublin -- Adrenal Collision Tumor / Michael P. Federle -- Adrenal Metastases / Mitchell Tublin -- SECTION 4 KIDNEY AND RENAL PELVIS -- Introduction to the Kidney, Renal Physiology, and Contrast / Alessandro Furlan -- Normal Variants and Pseudolesions -- Renal Fetal Lobation / Michael P. Federle -- Junctional Cortical Defect / Amir A. Borhani -- Congenital Note continued: Horseshoe Kidney / Michael P. Federle -- Renal Ectopia and Fusion / Sara M. O'Hara -- Renal Agenesis / A. Carlson Merrow, Jr. -- Ureteropelvic Junction Obstruction / Michael P. Federle -- Vesicoureteral Reflux / Sara M. O'Hara -- Ureteropelvic Duplications / Sara M. O'Hara -- Ureterocele / Sara M. O'Hara -- Congenital Megacalyces and Megaureter / Alessandro Furlan -- Megaureter-Megacystis / Judy Squires -- Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome / Sara M. O'Hara -- Prune-Belly Syndrome / Judy Squires -- Renal Lymphangiomatosis / Alessandro Furlan -- Posterior Urethral Valves / Sara M. O'Hara -- Infection -- Acute Pyelonephritis / Alessandro Furlan -- Chronic Pyelonephritis/Reflux Nephropathy / Amir A. Borhani -- Xanthogranulomatous Pyelonephritis / R. Brooke Jeffrey -- Emphysematous Pyelonephritis / R. Brooke Jeffrey -- Renal Abscess / R. Brooke Jeffrey -- Pyonephrosis / Alessandro Furlan Note continued: Opportunistic Renal Infections / Amir A. Borhani -- Renal Cystic Disease -- Renal Cyst / Alessandro Furlan -- Parapelvic/Peripelvic Cyst / Alessandro Furlan -- Autosomal Dominant Polycystic Kidney Disease / Alessandro Furlan -- Polycystic Kidney Disease, Autosomal Recessive / Sara M. O'Hara -- Multicystic Dysplastic Kidney / Sara M. O'Hara -- Acquired Cystic Renal Disease / Alessandro Furlan -- Von Hippel-Lindau Disease / Alessandro Furlan -- Lithium Nephropathy / Amir A. Borhani -- Localized Cystic Renal Disease / Michael P. Federle -- Benign Neoplasms -- Renal Angiomyolipoma (AML) / Matthew T. Heller -- Renal Oncocytoma / Matthew T. Heller -- Multilocular Cystic Nephroma / Michael P. Federle -- Metanephric Adenoma / Matthew T. Heller -- Mixed Epithelial and Stromal Tumor / Matthew T. Heller -- Malignant Neoplasms -- Renal Cell Carcinoma / Matthew T. Heller -- Renal Cell Carcinoma Staging / Vineet Krishan Khanna Note continued: Medullary Carcinoma / Matthew T. Heller -- Collecting Duct Carcinoma / Matthew T. Heller -- Renal Urothelial Carcinoma / Matthew T. Heller -- Renal Pelvis and Ureteral Carcinoma Staging / Akram M. Shaaban -- Renal Lymphoma / Matthew T. Heller -- Renal Metastases / Matthew T. Heller -- Pediatric Renal Masses -- Wilms Tumor / Hank Baskin -- Nephroblastomatosis / Judy Squires -- Mesoblastic Nephroma / A. Carlson Merrow, Jr. -- Rhabdoid Tumor / Judy Squires -- Clear Cell Sarcoma of Kidney / Ethan A. Smith -- Ossifying Renal Tumor of Infancy / Ethan A. Smith -- Metabolic -- Nephrocalcinosis / Michael P. Federle -- Urolithiasis / Matthew T. Heller -- Paroxysmal Nocturnal Hemoglobinuria / Matthew T. Heller -- Renal Failure and Medical Renal Disease -- Hydronephrosis / Alessandro Furlan -- Glomerulonephritis / Matthew T. Heller -- Acute Tubular Necrosis / Alessandro Furlan -- Renal Cortical Necrosis / Alessandro Furlan Note continued: Renal Papillary Necrosis / Mitchell Tublin -- Hemolytic Uremic Syndrome / A. Carlson Merrow, Jr. -- HIV Nephropathy / Alessandro Furlan -- Chronic Renal Failure / Alessandro Furlan -- Renal Lipomatosis / Amir A. Borhani -- Vascular Disorders -- Renal Artery Stenosis / Amir A. Borhani -- Renal Infarction / Amir A. Borhani -- Renal Artery Pseudoaneurysm/AVF / Mitchell Tublin -- Renal Vein Thrombosis / Amir A. Borhani -- Trauma -- Renal Trauma / Matthew T. Heller -- Urinoma / Matthew T. Heller -- Perinephric Hematoma / Katherine E. Maturen -- Transplantation -- Renal Transplantation / Mitchell Tublin -- Treatment Related -- Postoperative State, Kidney / Amir A. Borhani -- Radiation Nephritis / Amir A. Borhani -- Contrast-Induced Nephropathy / Amir A. Borhani -- SECTION 5 URETER -- Introduction to the Ureter / Paula J. Woodward -- Congenital -- Duplicated and Ectopic Ureter / Amir A. Borhani -- Inflammation -- Ureteritis Cystica / Michael P. Federle Note continued: Ureteral Stricture / Amir A. Borhani -- Malakoplakia / Amir A. Borhani -- Trauma -- Ureteral Trauma / Michael P. Federle -- Neoplasms -- Polyps / Amir A. Borhani -- Ureteral Urothelial Carcinoma / Amir A. Borhani -- Ureteral Metastases / Amir A. Borhani -- Miscellaneous -- Ureterectasis of Pregnancy / Amir A. Borhani -- SECTION 6 BLADDER -- Introduction to the Bladder / Paula J. Woodward -- Congenital -- Urachal Anomalies / Michael P. Federle -- Cloaca / Judy Squires -- Bladder Exstrophy / Judy Squires -- Infection -- Cystitis / Amir A. Borhani -- Bladder Schistosomiasis / Amir A. Borhani -- Degenerative -- Bladder Calculi / Michael P. Federle -- Bladder Diverticulum / Amir A. Borhani -- Fistulas of the Genitourinary Tract / Michael P. Federle -- Neurogenic Bladder / Michael P. Federle -- Trauma -- Bladder Trauma / Michael P. Federle -- Treatment Related -- Postoperative State, Bladder / Amir A. Borhani -- Benign Neoplasms Note continued: Mesenchymal Bladder Neoplasms / Amir A. Borhani -- Bladder Inflammatory Pseudotumor / Amir A. Borhani -- Bladder and Ureteral Intramural Masses / Amir A. Borhani -- Malignant Neoplasms -- Urinary Bladder Carcinoma / Amir A. Borhani -- Urinary Bladder Carcinoma Staging / Akram M. Shaaban -- Squamous Cell Carcinoma / Amir A. Borhani -- Rhabdomyosarcoma, Genitourinary / Judy Squires -- Adenocarcinoma / Amir A. Borhani -- SECTION 7 URETHRA/PENIS -- Introduction to the Urethra / Paula J. Woodward -- Neoplasms -- Urethral Carcinoma Staging / Christine O. Menias -- Infection -- Urethral Stricture / Michael P. Federle -- Urethral Diverticulum / Matthew T. Heller -- Trauma -- Urethral Trauma / Amir A. Borhani -- Erectile Dysfunction / Matthew T. Heller -- SECTION 8 TESTES NONNEOPLASTIC CONDITIONS -- Approach to Scrotal Sonography / Shweta Bhatt -- Cryptorchidism / Paula J. Woodward -- Testicular Torsion / Mitchell Tublin Note continued: Segmental Infarction / Mitchell Tublin -- Torsion of Testicular Appendage / A. Carlson Merrow, Jr. -- Tubular Ectasia / Shweta Bhatt -- Testicular Microlithiasis / Shweta Bhatt -- Neoplasms -- Germ Cell Tumors / Shweta Bhatt -- Testicular Lymphoma and Leukemia / Shweta Bhatt -- Testicular Carcinoma Staging / Akram M. Shaaban -- Stromal Tumors / Mitchell Tublin -- Epidermoid Cyst / Shweta Bhatt -- SECTION 9 EPIDIDYMIS -- Epididymitis/Epididymo-Orchitis / Amit B. Desai -- Adenomatoid Tumor / Mitchell Tublin -- Spermatocele/Epididymal Cyst / Mitchell Tublin -- Sperm Granuloma / Mitchell Tublin -- SECTION 10 SCROTUM -- Hydrocele / R. Brooke Jeffrey -- Varicocele / R. Brooke Jeffrey -- Pyocele / R. Brooke Jeffrey -- Paratesticular Rhabdomyosarcoma / Judy Squires -- Hernia / Amir A. Borhani -- Fournier Gangrene / Mitchell Tublin -- Scrotal Trauma / Shweta Bhatt -- SECTION 11 SEMINAL VESICLES -- Acquired Seminal Vesicle Lesions / Amir A. Borhani Note continued: Congenital Lesions / Amir A. Borhani -- SECTION 12 PROSTATE -- Prostatitis and Abscess / Paula J. Woodward -- Prostatic Cyst / Paula J. Woodward -- Introduction to Multiparametric MR of the Prostate / Alessandro Furlan -- Benign Prostatic Hypertrophy / R. Brooke Jeffrey -- Prostate Carcinoma / Alessandro Furlan -- Prostate Carcinoma Staging / Marta Heilbrun -- SECTION 13 PROCEDURES -- Percutaneous Genitourinary Interventions / Ashraf Thabet -- Kidney Ablation/Embolization / Ashraf Thabet -- Post Kidney Transplant Procedures / Ashraf Thabet -- Venous Sampling and Venography (Renal and Adrenal) / T. Gregory Walker.

This books brings together multi-disciplinary expertise to provide comprehensive information about molecular imaging of infectious diseases. Also described are the development of new imaging technologies for infectious disease and their translation to the clinic. The overall goal of Imaging Infections: From Bench to Bedside is to spur interest and innovation in this emerging field. We anticipate that these technologies will not only allow unique insights into understanding pathogenesis of infections but also expedite bench-to-bedside translation of new therapeutics. While molecular imaging is already in common use in the clinic, this book demonstrates how it could also become a valuable tool for clinical studies, patient care, public health, and for enabling precision medicine for infectious diseases.

This book provides an overview on the critical role of diagnostic imaging in the assessment of patients with suspected alimentary tract perforation, an emergent condition that requires prompt surgery. With the aid of numerous high-quality images, it is described how different imaging modalities, including plain film X-ray, ultrasonography, and multidetector row computed tomography (MDCT), permit correct diagnosis of the presence and cause of the perforation and of associated pathologies. Particular attention is paid to MDCT, with full description of its role in a range of scenarios at various levels of the alimentary tract. Imaging of GI tract perforation in different patient groups, such as pediatric patients, the elderly, and oncologic patients, is also addressed. This volume will greatly assist residents in radiology, radiologists, and physicians who are daily involved in the management of patients with clinically suspected alimentary tract perforation.

This book provides a detailed description of typical imaging features of bone tumors and tumor-like lesions in the shoulder and elbow. Each chapter deals with one major bone tumor or tumor-like lesions, for example, giant cell tumor, bone cyst, osteochondroma, chondrosarcoma, Ewing sarcoma, bone metastases, lymphoma, etc. Typical cases are carefully selected from thousands of clinical cases accompanying with comprehensive imaging information of X-ray, CT and MRI. In-depth analysis and differential diagnostic tips from experienced bone tumor specialists is presented at the end of each case. This book will be useful and worthy to musculoskeletal radiologists, orthopaedic surgeons, general radiologists, and oncologists.

Acute trauma and chronic strain : essentials -- Acute trauma and chronic strain (according to regions) -- Infections of the bones, joints and soft-tissues -- Tumors and tumor-like lesions of the bone, the joints and the spine -- Bone marrow -- Necroses of the skeletal system -- Osteochondroses -- Metabolic, hormonal and toxic osteopathies -- Constitutional disorders of bone and joint development -- Rheumatic disorders -- Miscellaneous bone, joint and soft-tissue disorders -- Interventions involving the bone, soft tissues and joints -- Radiology expert advisory reports on the skeleton and the joints.

Technologic innovations in MR and CT -- Normal anatomy -- Hemorrhage -- Ischemia -- Aneurysms -- Vascular malformations and other vascular lesions.

This book summarizes the imaging characteristics and theory of CNS infections, serving as a clinical guidance and having a practical significance for the understanding, prevention and diagnosis of infectious neurology. It includes extensive CT, MRI images on gross anatomy, pathological tissue, immunohistochemistry, electronic speculum, etc. It is divided into 19 chapters according to infectious types. On the basis of imaging diagnosis, through the cross research of imaging with autopsy and pathology, the imaging characteristics and evolution was revealed. This book will be a valuable reference on the clinical practice and research of neuroinfections.

Depending on their mechanism of action, the cytotoxic and targeted drugs and radiotherapy employed in oncologic treatment may cause complications and toxicities in many organ systems, with variable radiologic presentations. This comprehensive and excellently illustrated book covers the basics of therapy-induced complications and toxicities in oncologic patients, identifies their consequences for all the major organs, and describes the imaging of these impacts by means of the various radiologic modalities. By familiarizing radiologists with the most frequent and prominent toxicities that are recognizable on radiologic imaging following tumor therapy, it will facilitate identification of their early manifestations and permit differential diagnosis based on relevant findings.

This clinically-oriented collection of brain imaging results provides a unique and helpful approach to the epilepsy evaluation. The atlas is divided into sections according to general clinical categories with each category including a collection of clinical examples that span the category. Each example includes images across the relevant imaging modalities that relate to one patient, whose history accompanies the images. This case-based organization with clinical history and multiple images offers a complete visual understanding of the imaging findings and the corresponding relationship of each finding to the clinical presentation, treatment, and outcome. Images for the book are from the UCLA Seizure Disorder Center, which is a referral center that serves a large outpatient epilepsy patient population and performs approximately 500 inpatient epilepsy evaluations annually. Comprehensive and richly illustrated, this book will serve as a convenient resource in neurologic and radiologic practice, and useful for board exam review.

This book systematically covers the anatomy and pathology of the fetal brain and spine. It features a veritable treasure trove of ultrasound images illustrating every common finding, as well as rare lesions that are encountered in clinical practice. Wherever possible, it also includes 3D ultrasound and fetal MRI correlations.

Most ingested foreign bodies pass through the gastrointestinal tract without a problem. However, both ingested and inserted foreign bodies may cause serious complications, such as bowel obstruction or perforation. Foreign body aspiration is common in children, especially those under 3 years of age, and in these cases chest radiography and CT are the main imaging modalities. This textbook provides a thorough overview of the critical role of diagnostic imaging in the assessment of patients with suspected foreign body ingestion, aspiration, or insertion. A wide range of scenarios are covered, from the common problem of foreign body ingestion or aspiration in children and mentally handicapped adults through to drug smuggling by body packing and gunshot wounds. Guidance is offered on diagnostic protocols, and the value of different imaging modalities in different situations is explained. Helpful management tips are also provided. This textbook will prove invaluable for residents in radiology, radiologists, and physicians who are involved on a daily basis, within an emergency department, in the management of patients with suspected ingestion, aspiration, or insertion of foreign bodies.

This book addresses the most relevant imaging techniques in order to detect inflammation and infection in the most common cardiovascular diseases. The book presents data concerning molecular imaging (SPECT and PET) and cardiac magnetic resonance imaging (MRI) for each disease, with a special focus on the emerging role of hybrid PET/MR imaging. Different non-ischemic and ischemic diseases as well as cardiac infections are addressed in detail; these include: Cardiac sarcoidosis, Cardiac amyloidosis, the vulnerable plaque, Post-infarction inflammatory alterations, Pericarditis, Myocarditis, Cardiac devices infections, and Endocarditis. The book also provides a comprehensive discussion on new targets and new tracers, to date mostly investigated at a pre-clinical stage, thus constituting an excellent basis for translational imaging. Imaging of Inflammation and Infection in Cardiovascular Diseases will be of interest not only for experts in clinical imaging, but also pre-clinical scientists and will be invaluable for both nuclear medicine physicians and radiologists.

This book is devoted to the diagnosis and treatment of male breast pathology. It provides a comprehensive overview of current strategies for the diagnosis of breast malignancies in men, with a focus on imaging modalities. Ultrasound of male breast abnormalities is discussed in particular depth, but the roles of other imaging techniques, genetic tests, and interventional diagnostic modalities are also carefully covered. Special attention is paid to differential diagnosis of malignant and benign lesions, and the most important benign breast diseases are described and illustrated with high-quality images. A special chapter analyzes treatment strategy in men with breast malignancies and principles of follow-up after breast surgery. Individual chapters are also devoted to the diagnosis of recurrent cancer and cancer metastases. This up-to-date and richly illustrated book will interest and assist specialists in ultrasound diagnostics, radiologists, oncologists, and surgeons.

This book, now in a revised and updated second edition, provides a review of imaging abnormalities in orthopedic sports injuries. The first part of the book includes background information on relevant basic science and general imaging principles in sports traumatology, while the second part discusses the topography of various sports injuries. Each chapter highlights the merits of different imaging techniques, focusing on a specific clinical problem. The third part then examines natural history and monitoring. Several new chapters have been added, including a chapter on postoperative joint imaging in the sports patient as well as image-guided interventions in sports injuries. This well-illustrated book written by leading experts is a valuable resource for musculoskeletal as well as general radiologists, orthopedic surgeons, sports physicians, physiotherapists and anyone else involved in sports medicine.

This practical volume is intended for all radiologists, gastroenterologists, and surgeons who are responsible for, or interested in, the diagnosis and care of patients with diseases of the anal and perianal region. After an introductory section focusing on surgical, MRI, and US anatomy, up-to-date clinical and therapeutic information is provided on the full range of perianal inflammatory conditions, with special attention to Crohn's disease, ulcerative colitis, and sexually transmitted diseases. Physical and surgical examination is carefully discussed, with consideration of limitations, results, clinical needs, and the questions likely to be posed of imaging. The subsequent three sections provide detailed information on the different imaging modalities: transanal and transperineal ultrasound, contrast-enhanced MRI, and CT. Techniques, diagnostic accuracy, common and unusual disease patterns, artifacts, and pitfalls are clearly presented.

An increasing percentage of the population has at least one prosthetic joint. Imaging is required for both initial assessment and routine follow-up of the implant, and this book is intended as an informative and up-to-date guide to the subject. After an introductory section covering a range of background topics, the level of information offered by different imaging techniques in presurgical planning and postimplantation assessment is analyzed. The application of imaging to different joints is then carefully explored in chapters devoted to the foot and ankle, hip, knee, shoulder, and elbow, wrist and hand. In addition, two innovative chapters focus on periprosthetic DXA as the gold standard in monitoring implant survival and on the role of drug therapy in helping to ensure the durability of the prosthesis. A central feature of the book is its combination of the clinical and radiological perspectives; it will be of value to radiologists and orthopedic specialists, as well as residents in these disciplines.

The new series A-Z Notes in Radiological Practice and Reporting provides practical guides for residents and general radiologists, organized alphabetically, primarily according to disease or condition. All booklets are designed so as to cover a large spectrum of topics referring to different anatomical regions of interest. Entries typically include a short description of pathological and clinical characteristics, guidance on selection of the most appropriate imaging technique, a schematic review of potential diagnostic clues, and useful tips and tricks. The present booklet, enriched by illustrations and schemes, is devoted to gastrointestinal imaging. Major topics in CT and MR imaging of the small bowel, colon, rectum, and anus are treated concisely in alphabetical order. For each topic a brief review of clinical features and pathology is presented, followed by a short description of imaging technique and an accurate review of imaging findings and signs which are useful in the differential diagnosis of gastrointestinal disease.

Origin and classification of soft tissue tumors -- Soft tissue tumors in a large referral population: prevalence and distribution of diagnoses by age, sex, and location -- Imaging of soft tissue tumors -- Lipomatous tumors -- Vascular and lymphatic tumors -- Fibrous and fibrohistiocytic tumors -- Muscle tumors -- Neurogenic tumors -- Synovial tumors -- Extraskeletal osseous and cartilagenous tumors -- Tumors of uncertain histogenesis -- Superficial soft tissues masses -- Mass which may mimic soft tissue tumors -- Compartmental anatomy.

This richly illustrated book, in an extensively revised new edition, provides a comprehensive survey of the role of medical imaging studies in the detection, staging, grading, tissue characterization, and post-treatment follow-up of soft tissue tumors. The indications for and relative merits of various imaging modalities are fully described, with particular emphasis on the role of advanced MRI techniques that can improve diagnostic accuracy and evaluation of treatment response. The most recent version of the WHO Classification of Soft Tissue Tumors is introduced, and individual chapters are devoted to imaging of each of the tumor groups in that classification as well as other soft tissue masses. Numerous new illustrations of both common and rare tumors are included, providing a rich pictorial database of soft tissue masses. In addition, imaging findings are correlated with clinical, epidemiologic, and histologic data. Imaging of Soft Tissue Tumors will be of value in daily practice not only for radiologists but also for orthopedic surgeons, oncologists, and pathologists.

Section 1. Techniques for imaging -- section 2. Image and pattern analysis -- section 3. Scalp, skull, and meninges -- section 4. Normal brain anatomy -- section 5. Cerebrovascular anatomy and disease -- section 6. Craniocerebral trauma -- section 7. Cysts and tumors -- section 8. The phakomatoses -- section 9. Infection and inflammation -- section 10. Aging and degeneration -- section 11. Toxic and metabolic conditions -- section 12. Hydrocephalus -- section 13. Epilepsy.

Developmental Anatomy -- Normal Variations -- Anomalies -- Anomalies and Normal Variations of the Dens -- Trauma -- Miscellaneous Cervical Spine Problems.

"Modern imaging techniques have allowed researchers to non-invasively peer into the human brain and investigate, among many other things, the acute effects and long-term consequences of drug abuse. Here, we review the most commonly used and some emerging imaging techniques in addiction research, explain how the various techniques generate their characteristic images and describe the rational that researchers use to interpret them. In addition, examples of seminal imaging findings are highlighted that illustrate the contribution of each imaging modality to the expansion in our understanding of the neurobiological bases of drug abuse and addiction, and how they can be parlayed in the future into clinical and therapeutic applications"--Provided by publisher.

This is the first of two volumes that together provide a comprehensive analysis of the embryology, normal anatomy, and pathology of the liver and intrahepatic biliary tract as seen on modern diagnostic imaging techniques. In this volume, readers will find fundamental information on embryology, radiological anatomy, and anatomic variants. A thorough introduction is then provided to each imaging technique, including ultrasound, computed tomography, magnetic resonance imaging, nuclear medicine techniques, angiography, and interventional radiology. The remainder of the volume is devoted to non-tumoral pathology of the liver and intra-hepatic biliary tract. For each disease, readers will find full description of the roles of individual imaging modalities and extensive illustration of the imaging appearances. The authors are world-leading experts in the field, and the book will be an ideal reference for all members of the radiology community, from residents to experts. It will also aid clinicians during their daily practice.

This is the second of two volumes that together provide a comprehensive analysis of the embryology, normal anatomy, and pathology of the liver and intrahepatic biliary tract as seen on modern diagnostic imaging techniques. In this second volume, readers will find comprehensive description and illustration of the imaging appearances of tumoral pathologies, both in the "normal liver" and in the context of chronic liver disease and liver cirrhosis. In addition, the imaging findings in relation to different treatment approaches are presented, with extensive coverage of imaging of tumor response and post-treatment changes. The authors are world-leading experts in the field, and the book will be an ideal reference for all members of the radiology community, from residents to experts. It will also aid clinicians during their daily practice.

1. Introduction -- 2. Pinhole Bone Scanning -- 3. Gamma Correction -- 4. Technical Processing of Gamma Correction -- 5. Gamma Correction Pinhole Bone Scan -- 6. Experimental Gamma Correction 99mTc-HDP Pinhole Bone Scan, Diagnosis of Trabecular Microfracture in Young Rats -- 7. Preoperative Confirmatory Imaging Diagnosis of Femoral Neck Fracture -- 8. Gamma Correction Pinhole Scan of Surgical Specimen and Correlation of Thereof and H&E Stain Findings for Histological Identification -- 9. Hematoxylin-Eosin Stain of Calcifying Calluses in Trabecular Microfractures -- 10. Identification of Trabecular Microcalluses in GCPBS and H&E Stain -- 11. Quantitation of 99mTc-HDP Uptake in Microcallus Using Pixelized Method -- 12. Quantitation of Gamma Correction Pinhole Bone Scan and H&E Stain -- 13. Reciprocal Correlation of Shapes of Tracer Uptake and Findings of Surgical Specimen, GCPBS and H&E Stain -- 14. Morphobiochemical Diagnosis of Acute Trabecular Microcallus Using Gamma Correction 99mTc-HDP Pinhole Bone Scan with Histological Verification -- 15. Preoperative Diagnosis by Radiography and 99mTcHDP Pinhole Bone Scan -- 16. Surgical Specimens from Human Subjects -- 17. Preoperative Diagnosis by Radiography and 99mTcHDP Pinhole Bone Scan -- 18. Gamma Correction Pinhole Scanof Surgical Specimen and Correlation of Thereof and H&E Stain Findings for Histological Identification -- 19. Gamma Correction Pinhole Bone Scan -- 20. Identification of Trabecular Microfractures in GCPBS and H&E Stain -- 21. Quantification of Micro-Fracture Tracer Uptake Using Pixelized Measurement -- 22. Overall Considerations -- 23. Precise Differntial Diagnosis of Acute Bone Marrow Edema and Hemorrhage and Trabecular Microfracture Using Nave and Gamma Correction Pinhole Bone Scans, NIH ImageJ Densitometry, and Pixelized -- 24. Micofracture Measurement -- 25. Introduction -- 26. Clinical Materials -- 27. Techniques of Seriated Nave and Gamma Correction Pinhole Bone Scanning and Reference Conventional R adiography and Corroborative Coronal FS T2 weighted MRI -- 28. NIH ImageJ Densitometry of 99mTc-HDP Uptake Intensity Measurement in Bone Marrow Edema and Hemorrhage and Trabecular Microfracture on Seriated Naive and Gamma Correction Pinhole Bone Scans -- 29. Mathematic Measurement of Trabecular Microfracture Size with Unsuppressed 99mTc-HDP uptake -- 30. Differential 99mTc-HDP Uptake Intensity Measurement of Bone Marrow Edema and Hemorrhage Using ImageJ Densitometry -- 31. Histopathological Validation -- 32. Differential Diagnosis of Bone Marrow Edema and Hemorrhage Using ImageJ Densitometry -- 33. Innocuousness of Bone Marrow Edema to Intact Trabecula on Nave Pinhole Scan Showing Mild Tracer Uptake Which is Suppressed -- 34. Differential Image J Densitometry Intensity Values of 99mTc-HDP Uptake in Bone Marrow Edema and Hemorrhage and Trabecular Microfracture -- 35. Fractured Trabeculae with Unsuppressed Enhanced Tracer Uptake -- 36. Innocuousness of Edema to Intact Trabecula and Injuriousness of Hemorrhage to Already Broken Trabecula -- 37. H&E Stain Validation of Additive Bone Marrow Hemorrhage Which Injures Already -- 38. NIH Image J Densitometric Analysis of an Old MR Image of Histologically Proven "Edemalike"Bone Marrow Change in Knee -- 39. Discussion -- 40. Summary and Conclusions.

"Imaging of Traumatic Brain Injury is a radiological reference that covers all aspects of neurotrauma imaging and provides a clinical overview of traumatic brain injury (TBI). It describes the imaging features of acute head trauma, the pathophysiology of TBI, and the application of advanced imaging technology to brain-injured patients. Key Features: Covers acute as well as chronic traumatic brain injury Written in an easily accessible format, with pearls and summary boxes at the end of each chapter Includes state-of-the-art imaging techniques, including the multiplanar format, the utility of multiplanar reformats, perfusion imaging, susceptibility weighted imaging, and advanced MRI techniques. Contains over 250 high-quality images This book will serve as a practical reference for practicing radiologists as well as radiology residents and fellows, neurosurgeons, trauma surgeons, and emergency physicians"--Provided by publisher.

This book provides an extensive overview of the role of imaging in the detection, diagnosis, management, and follow-up of tuberculosis. Chapters cover the disease's epidemiology and pathophysiology, microbiological diagnosis and pathology relevant to radiologists, and the distinct aspects of imaging tuberculosis at various locations and body systems. This book discusses recent advances in imaging pertaining to tuberculosis, and addresses the approach to patients with tuberculosis and HIV co-infection. The final chapter offers an algorithmic approach to the diagnosis and management steps of tuberculosis. Imaging of Tuberculosis is an updated and comprehensive reference source that covers imaging of tuberculosis in a structured fashion and is valuable for radiologists.

During the past decade, the medical and surgical treatment of ulcerative colitis has undergone dramatic advances, including the widespread use of immunomodulators, biological drugs, and restorative proctocolectomy. In order to correctly balance the risks and benefits of medical therapies and surgical procedures, there is a need for improved diagnosis of colonic disease, acute complications, extraintestinal manifestations, and early and delayed postoperative complications. Cross-sectional imaging techniques are therefore playing an increasing role in the assessment of ulcerative colitis and provide an essential complement to clinical data and endoscopy. This practical, illustrated volume on the role of cross-sectional imaging is aimed at radiologists, gastroenterologists, and surgeons who are engaged or interested in the diagnosis and care of patients with inflammatory bowel disease, particularly ulcerative colitis. After an overview of diagnostic imaging techniques, state-of-the-art assessment of colorectal inflammatory disease with CT colonography using water enema and bowel MRI is discussed, followed by description of the plain radiographic and CT findings in patients with acute exacerbations and surgical complications. Subsequent chapters review the diagnostic findings and role of cross-sectional imaging in the assessment of sclerosing cholangitis (with emphasis on MR cholangiopancreatography), vascular complications (particularly portal and mesenteric thrombosis), colitis-associated colorectal cancer and perianal inflammatory disease. Normal postoperative appearances and early and delayed complications in patients treated with proctocolectomy and ileal pouch-anal anastomosis are also comprehensively reviewed.

1. Diagnostics of pelvicalyceal diverticula -- 2. Diagnostics of ureteral diverticula -- Diagnostic Imaging of urinary bladder diverticula -- 4. Urethral diverticula -- Appendix.

Radiographic imaging -- Mammographic imaging -- Fluoroscopy with image intensifiers -- Interventional radiology with flat-panel detectors -- Computed tomography imaging -- Gamma cameras -- Single-photon emission computed tomography and position emission tomography imaging -- Magnetic resonance basics -- Magnetic resonance imaging -- Ultrasound basics -- Ultrasound imaging and doppler -- Radiation doses -- Radiation safety

This book reviews in detail the role of neuroradiological imaging in the evaluation of patients who have undergone surgery or interventional radiology procedures, and particularly its value in the documentation of normal and pathological post-treatment changes, detection of complications, and follow-up. The opening sections describe pretreatment images in various conditions, including trauma, degenerative disc disease, and osteoporosis, and the different types of neurosurgical and interventional treatment that may be used. The post-treatment appearances of normal sequelae and complications on conventional radiography, CT, and MRI are then documented in detail on the basis of a large series of clinical cases, with a wealth of images. Guidance is provided on selection of one or a combination of imaging modalities. This book will be an invaluable clinical and research tool not only for neuroradiologists but also for neurosurgeons, and interventional radiologists.

This book is an up-to-date guide to the performance and interpretation of imaging studies in dental radiology. After opening discussion of the choice of X-ray equipment and materials, intraoral radiography, panoramic radiography, cephalometric radiology, and cone-beam computed tomography are discussed in turn. With the aid of many illustrated examples, patient preparation and positioning are thoroughly described for each modality. Common technical errors and artifacts are identified and the means of avoiding them, explained. The aim is to equip the reader with all the information required in order to perform imaging effectively and safely. The normal radiographic anatomy and landmarks are then discussed, prior to thorough coverage of frequent dentomaxillofacial lesions. Accompanying images display the characteristic features of each lesion. Further topics to be addressed are safety precautions for patients and staff. The book will be an ideal aid for all dental practitioners and will also be of value for dental students.

Data compiled by the Center for Disease Control and Prevention indicates an alarming and continuing increase in the prevalence of autism. Despite intensive research during the last few decades, autism remains a behavioral defined syndrome wherein diagnostic criteria lack in construct validity. And, contrary to other conditions like diabetes and hypertension, there are no biomarkers for autism. However, new imaging methods are changing the way we think about autism, bringing us closer to a falsifiable definition for the condition, identifying affected individuals earlier in life, and recognizing different subtypes of autism. The imaging modalities discussed in this book emphasize the power of new technology to uncover important clues about the condition with the hope of developing effective interventions. Imaging the Brain in Autism was created to examine autism from a unique perspective that would emphasize results from different imaging technologies. These techniques show brain abnormalities in a significant percentage of patients, abnormalities that translate into aberrant functioning and significant clinical symptomatology. It is our hope that this newfound understanding will make the field work collaborative and provide a path that minimizes technical impediments.

Work in intensive care is dynamic and often requires swift decision-making to achieve the best patient outcome. This book serves as a practical guide for professionals working in this demanding area of medicine. It reviews diagnostic options as well as strengths and weaknesses of imaging techniques in clinical scenarios familiar to most ICU clinicians. The concise format allows rapid access to key information. Imaging the ICU Patient is a true collaboration between critical care and radiology. It demystifies the process of deciding when and how to image the critically ill patient. Using a symptom-orientated approach, it addresses techniques as well as patient safety issues. It is meant to be used by critical care clinicians and radiologists and aims to foster a better appreciation of the concerns both specialties have when imaging critically ill patients.

This book provides a detailed and comprehensive overview of the role of diagnostic imaging in the assessment and management of trauma and polytrauma in children. The coverage includes imaging of injuries to the head, thorax, abdomen, bone and musculoskeletal system, with careful attention to the newest imaging techniques, imaging during the course of recovery, and imaging of complications. A series of illustrative cases underline the prognostic value of imaging. In addition, an individual chapter is devoted to diagnostic imaging in cases of child abuse. The book concludes by discussing informed consent and medicolegal issues related to the imaging of pediatric traumatic emergencies. Imaging Trauma and Polytrauma in Pediatric Patients will be invaluable in enabling radiologists and clinicians to identify the main features and signs of injuries on a wide range of imaging techniques, including X-ray, ultrasonography, computed tomography, and magnetic resonance imaging.

Part 1: Imagining the brain between body and soul. Ventricular localization in late antiquity: the philosophical and theological roots of an enduring model of brain function / Jessica Wright -- The pathological and the normal: mapping the brain in medieval medicine / William MacLehose -- Imagining the soul: Thomas Willis (1621–1675) on the anatomy of the brain and nerves / Alexander Wragge-Morley -- Gaetano Zumbo’s anatomical wax model: from skull to cranium / Rose Marie San Juan -- Part 2: Representing the brain and the nervous system: styles, media, practices. The nervous system and the anatomy of expression: Sir Charles Bell’s anatomical watercolours / Brendan Clarke and Chiara Ambrosio -- Gertrude Stein’s modernist brain / Chiara Ambrosio -- Imagining the brain as a book: Oskar and Cécile Vogt’s "library of brains" / Chantal Marazia and Heiner Fangerau -- Pinpricks: Needling, numbness, and temporalities of pain / Lan A. Li -- Part 3: Inside the brain: arguments and evidence in the making of the modern neurosciences. From images to physiology: a strange paradox at the origin of modern neuroscience / Paolo Mazzarello -- One, no-one and a hundred thousand brains: J.C. Eccles, J.Z. Young and the establishment of the neurosciences (1930s–1960s) / Fabio De Sio -- Seeing patterns in neuroimaging data / Jessey Andrew Kenneth Wright.

New opportunities for immobilization of enzymes / Jose M. Guisan -- Immobilization of enzymes : a literature survey / Beatriz Brena, Paula González-Pombo, and Francisco Batista-Viera -- Glutaraldehyde-mediated protein immobilization / Fernando López-Gallego, Jose M. Guisán, and Lorena Betancor -- Immobilization of enzymes on monofunctional and heterofunctional epoxy-activated supports / Cesar Mateo, Valeria Grazu, and Jose M. Guisan -- Stabilization of enzymes by multipoint covalent immobilization on supports activated with glyoxyl groups / Fernando López-Gallego ... [et al.] -- Oriented covalent immobilization of enzymes on heterofunctional-glyoxyl supports / Cesar Mateo ... [et al.] -- Reversible covalent immobilization of enzymes via disulfide bonds / Karen Ovsejevi, Carmen Manta, and Francisco Batista-Viera -- Immobilization of Candida rugosa lipase on superparamagnetic Fe3O4 nanoparticles for biocatalysis in low-water media / Joyeeta Mukherjee, Kusum Solanki, and Munishwar Nath Gupta -- Immobilization of enzymes by bioaffinity layering / Veena Singh, Meryam Sardar, and Munishwar Nath Gupta -- Immobilization of enzymes on magnetic beads through affinity interactions / Audrey Sassolas, Akhtar Hayat, and Jean-Louis Marty -- Tips for the functionalization of nanoparticles with antibodies / Ester Polo ... [et al.] -- Design and characterization of functional nanoparticles for enhanced bio-performance / Pablo del Pino, Scott G. Mitchell, and Beatriz Pelaz -- Immobilization of enzymes on ethynyl-modified electrodes via click chemistry / Akhtar Hayat ... [et al.] -- Modification of carbon nanotube electrodes with 1-pyrenebutanoic acid, succinimidyl ester for enhanced bioelectrocatalysis / Guinevere Strack ... [et al.] -- Enzyme immobilization by entrapment within a gel network / Audrey Sassolas, Akhtar Hayat, and Jean-Louis Marty -- Practical protocols for lipase immobilization via sol-gel techniques / Manfred T. Reetz -- Improving lipase activity by immobilization and post-immobilization strategies / Jose M. Palomo ... [et al.] -- High activity preparations of lipases and proteases for catalysis in low water containing organic solvents and ionic liquids / Ipsita Roy ... [et al.] -- Biomedical applications of immobilized enzymes : an update / Marta Pastor, Amaia Esquisabel, and José Luis Pedraz -- Immobilization of whole cells by chemical vapor deposition of silica / Susan R. Sizemore ... [et al.] -- Encapsulation of cells in alginate gels / Pello Sánchez ... [et al.] -- Microalgal immobilization methods / Ignacio Moreno-Garrido -- Therapeutic applications of encapsulated cells / Argia Acarregui ... [et al.] -- Whole cell entrapment techniques / Jorge A. Trelles and Cintia W. Rivero.

This book delves into the field of immobilizing biologically active and non-active molecules. It discusses the designing strategy of immobilization and the current state-of-the-art applications for advancing biomedical, agricultural, environmental and industrial practices. It focuses on aspects ranging from fundamental principles to current technological advances at multi-scale levels (macro, micro, and nano) which are suitable for cell, enzyme, and nano-catalyst based applications. Written by experts from across the globe, the contents deal with illustrated examples of molecular and cellular interactions with materials/scaffolds and discussions on factors that can affect the functionality and yield of the process. With its discussions on material science, design of delivery vehicles, separation science, additive manufacturing, agriculture and environmental science, this book will be a useful reference for researchers across multiple disciplines.

This text provides a concise yet comprehensive overview of the most common autoimmune cytopenias affecting adults and children. The book is divided into four sections, each of which focuses on a major autoimmune cytopenia. The first section features background, pathophysiology, presentation, evaluation, and treatment strategies for immune thrombocytopenia (ITP), the most common cause of antibody-mediated platelet destruction. The second section reviews common forms and treatment strategies for autoimmune hemolytic anemia (AIHA), including a chapter dedicated specifically to Evans Syndrome. The third section comprehensively reviews the pathophysiology, diagnosis and current management approaches to thrombotic thrombocytopenic purpura (TTP), a potentially life-threatening autoimmune syndrome. The book concludes with a final section on autoimmune neutropenia. Each section includes a review of common underlying systemic autoimmune conditions and immune deficiency syndromes that can accompany or cause autoimmune cytopenias. Written by experts in each content area, Immune Hematology: Diagnosis and Management of Autoimmune Cytopenias is a valuable resource for clinicians and professionals who treat patients afflicted with autoimmune cytopenias, including primary care providers, hematologist/oncologists, immunologists, among others.

Quantitating lymphocyte programmed cell death in vitro using simple kill assays / Lixin Zheng -- Fluorescence-activated cell sorting-based quantitation of T cell receptor restimulation-induced cell death in activated, primary human T cells / Gil Katz and Andrew L. Snow -- Evaluation of IL-2-withdrawal-induced apoptosis in human T lymphocytes / Joao Bosco Oliveira -- Determination of apoptosis sensitivity in specific T cell subsets from human peripheral blood by utilizing a multiparameter fluorescence-activated cell sorting-based technique / Bernice Lo and Madhu Ramaswamy -- Visualization of fas-mediated death-inducing signaling complex formation by immunoprecipitation / Nelia Cordeiro and Nicolas Bidere -- Analyses of programmed cell death in dendritic cells / Min Chen, Lily Huang, and Jin Wang -- Detection of necrosis by release of lactate dehydrogenase Activity / Francis Ka-Ming Chan, Kenta Moriwaki, and Maria Jose De Rosa -- Assessment of CD4+ and CD8+ T cell responses using MHC class I and II tetramers / Sema Kurtulus and David Hildeman -- Homeostatic proliferation of mature T cells / Christopher E. Martin [and others] -- Quantitating lymphocyte homeostasis in vivo in humans using stable isotope tracers / Liset Westera [and others] -- Real-time quantitative (RQ- )PCR approach to quantify the contribution of proliferation to B lymphocyte homeostasis / Menno C. van Zelm [and others] -- Molecular measurement of T cell receptor excision circles / Heather E. Lynch and Gregory D. Sempowski -- Isolation of RNA and the synthesis and amplification of cDNA from antigen-specific T cells for genome-wide expression analysis / R. Anthony Barnitz [and others] -- Designs for massively parallel sequencing approaches to identify causal mutations in human immune disorders / Yu Zhang and Helen C. Su -- Flow cytometric measurement of SLAM-associated protein and x-linked inhibitor of apoptosis / Rebecca A. Marsh, Jack J. Bleesing, and Alexandra H. Filipovich -- In vitro suppression assay for functional assessment of human regulatory T cells / Dat Q. Tran.

This book offers comprehensive coverage of both basic and clinical aspects of immune reactions responsible for infertility. It has four sections focusing on Sperm antigens, Antisperm antibodies (ASAs), Clinical impact of ASAs, and Immune contraception, and include contributions from leading experts in these fields. This new edition of the book offers a comprehensive update that reflects the very significant advances in reproductive immunology that have been achieved over the past five years, especially related to the sperm proteome, sperm-egg binding/fusion proteins, gene knockout studies, and immunocontraception. Reproductive immunology continues to be a fast-growing discipline in which new knowledge is emerging almost every day. Immune Infertility is a model source of vital and reliable information on the latest scientific developments in the field. It will be of value for clinicians, scientists, students, residents, and fellows working in reproductive biology, obstetrics and gynecology, and urology.

"This book offers a broad overview of the concepts and research findings in immunometabolism. The immune system is made up of numerous different cell types, pathways, and components that must be able to respond rapidly to a pathogen or cancer, but must also remain quiescent in the absence of challenges. Immune cells rely on metabolic pathways to adapt to changing environments and stimuli. Additionally, these cells can be modified in function or fate by fluctuations in available nutrients. The chapters in this book describe ways in which immune cells utilize and are regulated by metabolic pathways. Topics include how immune-cell metabolism shapes immune homeostasis, and how dysregulation of these pathways can lead to immune disorders. In different contexts, such as a tumor microenvironment, immune-cell function and identity may be modified not only by cytokines and checkpoint molecules, but also by nutrient availability and other metabolic stimuli. Transcriptional reprogramming confers many of the changes in immune cell metabolism that are seen when a T-cell, for example, undergoes activation or functional adaptation to different environments. Lastly, immune cells can destructively or protectively participate in human metabolic homeostasis or disorders. This book summarizes immune-metabolism from a variety of different perspectives, including the ways in which metabolic cues, pathways, and requirements of immune cells change in conditions of homeostasis and activation. The exploration of the significance of metabolic checkpoints and other cues, particularly in the context of cancer and immune disorders, may form the foundation for the development of therapeutics"--Publisher's description.

These guidelines, compiled by a panel of clinicians and scientists with a high level of expertise, aim to provide readers with the most up-to-date and comprehensive instructions on the treatment and prevention of ocular inflammation. All of the recommendations are explicitly linked to supporting evidence and graded according to the strength of that evidence, and the editors have made every effort to ensure that chapters are of a consistently high methodological quality. The guidelines for each treatment include dose and the frequency and mode of delivery. Significant side-effects of treatment are identified and distinguished from those of the disease in question. Suggestions are presented for the prevention both of the disease itself and of the treatment-related complications. In addition, likely future directions in treatment and prevention are identified. These guidelines will be of great practical value for all clinicians and clinical scientists with an interest in the subject.

Host response to implanted materials and devices, overview -- Innate and acquired immunity: umoral and cellular components (Protein adsorption, cell recruitment, tissue response) -- Acute/Chronic inflammation, foreign body reaction -- implications -- Macrophages: from immune response to tissue restoration -- Host response to cell-grafted biomaterials -- Host response to therapeutic nanoparticles -- Host response to synthetic versus natural biomaterials (The effects of the composition, structure on function, stability, and final outcome) -- Biomimicry at the cell-material interface to mitigate the immune reaction -- Bioactive materials design for immunomodulation. exploiting the patient's own body machinery to achieve functional tissue restoration -- Host response to materials for orthopaedic applications: current approaches and future perspectives -- Methods to activate cellular immunity or determine immune evasion.

1. Thromboinflammation in therapeutic medicine -- 2. Complement interactions with blood cells, endothelial cells and microvesicles in thrombotic and inflammatory conditions -- 3. Role of complement on broken surfaces after trauma -- 4. Complement involvement in periodontitis: molecular mechanisms and rational therapeutic approaches -- 5. The lectin pathway of complement and biocompatibility -- 6. Foreign body reaction to subcutaneous implants -- 7. Molecular characterization of macrophage-biomaterial interactions -- 8. Heparan sulfate proteoglycan metabolism and the fate of grafted tissues -- 9. Xenotransplantation of cells, tissues, organs and the Greman research foundation Transregio Collaborative Research Centre 127 -- 10. Macroencapsulated pig islets correct induced diabetes in primates up to 6 months -- 11. Regulation of instant blood mediated inflammatory reaction (IBMIR) in pancreatic islet xeno-transplantation: points for therapeutic interventions -- 12. Cell surface engineering for reguation of immune reactions in cell therapy -- 13. Complement interception across humoral incompatibility in solid organ transplantation: a clinical perspective -- Index.

"The Immune System, Fourth Edition, emphasizes the human immune system and synthesizes immunological concepts into a coherent, up-to-date, and reader-friendly account of how the immune system works. Written for undergraduate, medical, veterinary, dental, and pharmacy students, it makes generous use of medical examples to illustrate points. The Fourth Edition has been extensively revised and updated. Innate immunity has undergone major revision to reflect this expanding and fast-moving field, and is now divided between two chapters: Chapter 2 "Innate Immunity: The Immediate Response to Infection," which deals with complement and other soluble molecules of innate immunity such as antimicrobial peptides, and Chapter 3 "Innate Immunity: The Induced Response to Infection," which deals mainly with the cellular response. Chapters 4-9 have been updated and material has been consolidated to eliminate repetition. Mucosal immunology has exploded as a field since the Third Edition was published, thus its coverage in chapter 10, now devoted to the topic, has been significantly expanded and updated. Also, more emphasis is placed on commensal microorganisms, particularly of the gut, and their interactions with the immune system. Immunological memory and the secondary immune response is now the first part of Chapter 11. The second part of this chapter, entitled "Vaccination to Prevent Infectious Disease," will include new and more modern material. "Bridging Innate and Adaptive Immunity" will also have its own chapter. The remaining clinical chapters will be revised and updated with new immunotherapies, but their content and organization will remain largely the same. The Fourth Edition will be accompanied by an updated and greatly expanded question bank, as well as PowerPoints and JPEGs of all the figures in the text."-- Provided by publisher.

"A clear, concise, and contemporary presentation of immunological concepts. This text emphasizes the human immune system and presents concepts with a balanced level of detail to describe how the immune system works. Written for undergraduate, medical, veterinary, dental, and pharmacy students, it makes generous use of medical examples to illustrate points. This classroom-proven textbook offers clear writing, full-color illustrations, and section and chapter summaries that make the content accessible and easily understandable to students"-- Provided by publisher.

The Immune System and Mental Health fully investigates how immune-related cellular, molecular and anatomical changes impact mental functioning. The book combines human and animal studies to reveal immunological changes related to mental-health problems. In addition, users will find comprehensive information on new research related to the microbial composition of the gut, aka, the microbiome, and how it influences brain function and mental health. Common comorbidities with mental illness and their inherent immunological or inflammatory components are also covered. Written by leaders in the field, the book synthesizes basic and clinical research to provide a thorough understanding on the role of immunity in neuropsychiatry. Sociology, psychology, psychiatry, neuroscience and genetics have provided considerable explanations and solutions to some of the most intractable mental-health problems. But researchers are increasingly relying on investigations of the immune system to identify factors that can undermine and impair mental health. This book covers devastating mental-health conditions, such as depression, anxiety, schizophrenia, and autism-like spectrum disorders. In addition, degenerative disorders of the brain, such as Parkinson's and Alzheimer's-like dementia are explored.

A General Description of HSPs, The Molecular Structure of HSP70 and The HSP70 Cycle -- The Functions of HSP70 in Normal Cells -- HSP70 in Damaged Cells -- Mechanisms of Activation and Inactivation of HSP70 Synthesis -- HSP70 in the Immune Responses -- HSP70 in Carcinogenesis -- HSP70 in aging -- The role of HSP70 in the protection of: (A) The brain in alzheimer's disease and (B) The heart in cardiac surgery.

Development and antigen receptor gene assembly: TET proteins and 5-methylcytosine oxidation in the immune system / Ageliki Tsagaratou, Anjana Rao ; Control of antigen receptor diversity through spatial regulation of V(D)J recombination / Anja Ebert, Jasna Medvedovic, Hiromi Tagoh, Tanja A. Schwickert, Meinrad Busslinger ; Establishment and maintenance of B cell identity / Rudolf Grosschedl ; Transcriptional establishment of cell-type identity : dynamics and causal mechanisms of T-cell lineage commitment / Ellen V. Rothenberg, Ameya Champhekar, Sagar Damle, Marissa Morales Del Real, Hao Yuan Kueh, Long Li, Mary A. Yui ; The epigenetics of early lymphocyte development / C. Murre -- Gene regulation: Regnase-1, a ribonuclease involved in the regulation of immune responses / Shizuo Akira ; Toward an understanding of the gene-specific and global logic of inducible gene transcription / Stephen T. Smale, Scott E. Plevy, Amy S. Weinmann, Liang Zhou, Vladimir R. Ramirez-Carrozzi, Scott D. Pope, Dev M. Bhatt, Ann-Jay Tong ; Tolerization of inflammatory gene expression / John J. Seeley, Sankar Ghosh -- The 'histone mimicry' by pathogens / Uwe Schaefer, Jessica S.Y. Ho, Rab K. Prinjha, Alexander Tarakhovsky -- Development and function of myeloid subsets: Myb-independent macrophages : a family of cells that develops with their tissue of residence and is involved in its homeostasis / Elisa Gomez Perdiguero, Frederic Geissmann ; The molecular choreography of IRF4 and IRF8 with immune system partners / Harinder Singh, Elke Glasmacher, Abraham B. Chang, Bryan Vander Lugt -- The IRF family transcription factors at the interface of innate and adaptive immune responses / Hiroaki Ikushima, Hideo Negishi, Tadatsugu Taniguchi -- T-cell differentiation and function: IL-1b strikingly enhances antigen-driven CD4 and CD8 t-cell responses / S.Z. Ben-Sasson, K. Wang, J. Cohen, W.E. Paul ; A modified model of t-cell differentiation based on mTOR activity and metabolism / Jonathan D. Powell, Emily B. Heikamp, Kristen N. Pollizzi, Adam T. Waickman ; Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the Phosphatase CD45 / Ying Xim Tan, Julie Zikherman, Arthur Weiss -- NK cells and innate lymphoid cells: Dissection of signaling in inflammation : three novel inflammatory regulators / Thorsten Berger, Mary E. Saunders, Tak W. Mak ; Tissue-resident natural killer cells / Wayne M. Yokoyama, Dorothy K. Sojka, Hui Peng, Zhigang Tian -- Microbial immunity: Immunology taught by human genetics / Jean-Laurent Casanova, Laurent Abel, Lluis Quintana-Murci ; Systems approach to understand the immune response in tuberculosis : an iterative process between mouse models and human disease / Anne O'Garra ; The zebrafish guide to tuberculosis immunity and treatment / Lalita Ramakrishnan ; Microbiota : host interactions in mucosal homeostasis and systemic autoimmunity / Randy S. Longman, Yi Yang, Gretchen E. Diehl, Sangwon V. Kim, Dan R. Littman ; The promised land of human immunology / Laura F. Su, Arnold Han, Helen M. McGuire, David Furman, Evan W. Newell, Mark M. Davis -- Tolerance, TREGS, and inflammasome: Transcriptional control of regulatory t-cell differentiation / Joris van der Veeken, Aaron Arvey, Alexander Rudensky -- miR-181 and metabolic regulation in the immune system / Adam Williams, Jorge Henao-Mejia, Christian C.D. Harman, Richard A. Flavell ; Encoding immunological memory in the initiation of b-cell receptor signaling / Susan K. Pierce, Wanli Liu -- Tumor immunology and genome stability: Programmed cell death 1-directed immunotherapy for enhancing t-cell function / Koichi Araki, Ben Youngblood, Rafi Ahmed ; Immune surveillance of unhealthy cells by natural killer cells / Alexandre Iannello, David H. Raulet ; Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice / Tomoharu Yasuda, Tristan Wirtz, Baochun Zhang, Thomas Wunderlich, Marc Schmidt-Supprian, Thomas Sommermann, Klaus Rajewsky -- Closing lecture: Pathogen-sensing, regulatory t cells, and responsiveness-tuning collectively regulate foreign- and self-antigen mediated t-cell responses / William E. Paul, Joshua D. Milner, Zvi Grossman.

Module 1. Target diseases and vaccines -- Module 2. The vaccine cold chain -- Module 3. Ensuring safe injections -- Module 4. Microplanning for reaching every community -- Module 5. Managing an immunization session -- Module 6. Monitoring and surveillance -- Module 7. Partnering with communities.

This book aims to describe the achievements, policy and system of immunization management in China during the last 60 years. Immunization is one of the most effective and cost-effective means to prevent infectious diseases. The Chinese government has long attached great importance to immunization, and with several generations of effort, China has made great achievements through its immunization program. The book consists of 9 chapters, including the introduction of vaccination and immunization policy, immunization services, innovative vaccines, immunization activities in China. The book also demonstrates some of the hardships and difficulties behind the immunization achievements, and introduces the effort of Expanded Program of Immunization (EPI) staff and the support and assistance from the international community.

Immunotherapies in early and advanced renal cell cancer / Kasenda, B., Larkin, J., Gore, M. -- Immunotherapy of brain tumors / Dutoit, V., Migliorini, D., Walker, P.R., Dietrich, P.-Y. -- Immunotherapy of melanoma / Snyder, A., Zamarin, D., Wolchok, J.D. -- Immunotherapy of breast cancer / Criscitiello, C., Curigliano, G. -- Current developments in actively personalized cancer vaccination with a focus on RNA as the drug format / Diken, M., Kreiter, S., Kloke, B., Sahin, U. -- Immune checkpoint inhibitors / Haanen, J.B.A.G., Robert, C. -- Radiotherapy and immunotherapy : improving cancer treatment through synergy / Reynders, K., De Ruysscher, D. -- Combinations therapies / Reinmuth, N., Reck, M. -- Promise of immunotherapy in lung cancer / Shanker, A., Dikov, M.M., Carbone, D.P. -- T cell engineering / Pircher, M., Schirrmann, T., Petrausch, U.

This book presents a thorough and critical review of current knowledge on the role of immunology in major psychiatric disorders and its potential applications. The opening chapters offer general information on the immune influence of the brain to provide readers with a better understanding of the end of immune privilege. The book then examines possible underlying mechanisms leading to psychiatric disorders, from early infections to pro-inflammatory markers, stress, and immune genetic background, linking etiology and psychiatry. The third section describes each disorder (ie autism, schizophrenia, bipolar disorder, depression, with an overview of underlying immune dysfunctions. Lastly, the authors discuss the innovative immune-therapies that may result from the discovery of immune system biomarkers and their associated mechanisms. A better understanding of the role of the immune system in psychiatric disorders makes it possible to identify stratification biomarkers, to explain underlying mechanisms, and to develop innovative, efficient, targeted treatment strategies and management. As such, the book is of value to clinicians, mental health professionals, mental health researchers, immunologists, industry practitioners, and various stakeholders in the mental health field.

Immuno Systems Biology aims to study the immune system in the more integrated manner on how cells and molecules participate at different system levels to the immune function. Through this book Kumar Selvarajoo introduces to physicists, chemists, computer scientists, biologists and immunologists the idea of an integrated approach to the understanding of mammalian immune system. Geared towards a researcher with limited immunological and computational analytical experience, the book provides a broad overview to the subject and some instruction in basic computational, theoretical and experimental approaches.

How to use this book / David Wild -- Immunoassay for beginners / David Wild -- Immunoassay performance measures / Chris Davies -- Principles of competitive and immunometric assays (including ELISA) / Chris Davies -- Non-competitive immunoassays for small molecules : the anti-complex and selective antibody systems / Colin H. Self ... [et al.] -- Homogeneous immunoassays / Edwin F. Ullman -- Lateral flow immunoassay systems : evolution from the current state of the art to the next generation of highly sensitive, quantitative rapid assays / Brendan O'Farrell -- Ambient analyte assay / Roger Ekins -- Free analyte immunoassay / Nic D. Christofides -- Qualitative immunoassay : features and design / Jianwen He, Simon Parker -- Detection of antibodies relevant to infectious disease / Steven Binder, Jennifer A. Isler -- Microsphere-based multiplex immunoassays : development and applications using Luminex® Xmap® technology / Sherry A. Dunbar, Michaela R. Hoffmeyer -- Lab-on-a-chip, micro- and nanoscale immunoassay systems, and microarrays / Simon Rattle ... [et al.] -- Immunological biosensors / Jason Reed, James K. Gimzewski -- Surface plasmon resonance in binding site, kinetic, and concentration analyses / Robert Karlsson -- Measurement of single protein molecules using digital ELISA / David M. Rissin, David H. Wilson, David C. Duffy -- Antibodies / Eryl Liddell -- Signal generation and detection system (excluding homogeneous assays) / Ian Weeks, Larry J. Kricka, David Wild -- Separation systems / David Wild, Wlad Kusnezow -- Conjugation methods / Alastair H. Dent -- Standardization and calibration / David Wild, Chris Sheehan -- Calibration curve fitting / John Dunn, David Wild -- The foundations of immunochemistry / Robert F. Ritchie -- Immunohistochemistry and immunocytochemistry / Simon Renshaw -- Practical guide to ELISA development / Jianwen He -- Method evaluation : a practical guide / Chris Sheehan, Jianwen He, Mari Smith -- Interferences in immunoassay / Jason Y. Park, Larry J. Kricka -- Immunoassay development in the in vitro diagnostic industry / Doug Brandt, Steve Figard -- Sample collection, including participant preparation and sample handling / Colin Wilde ... [et al.] -- Quality assurance / Catharine M. Sturgeon -- Point-of-care testing / James H. Nichols -- Choosing an automated immunoassay system / Lori J. Sokoll -- Immunoassay troubleshooting guide / David Wild, Jianwen He -- Introduction to immunoassay product technology in clinical diagnostic testing / David Wild, Chris Sheehan, Steve Binder -- Market trends / David Huckle -- Lateral flow and consumer diagnostics / Sarah Tiplady -- Consumer diagnostics : Clearblue pregnancy and fertility testing / Sarah Tiplady -- The Triage® system / Thomas I. Koshy, Kenneth F. Buechler -- Stratus® CS Acute Care[TM] STAT fluorometric analyzer / Amy Sarli, W.N. McLellan -- IMX® / Kent Ford -- AXSYM® / Theresa Donahoe -- Abbott Architect® family of analyzers / Frank A. Quinn, David A. Armbruster -- Advia Centaur® XP / Jean Metzar -- Immulite® and Immulite 1000 / Arthur L. Babson -- VITROS® ECiQ Immunodiagnostic System, VITROS® 3600 Immunodiagnostic System, and VITROS® 5600 Integrated System / John W. Backus, David Wild -- VITROS® Immuno-Rate and Microtip[TM] assays / John W. Backus, Susan J. Danielson, David A. Hilborn -- Access 2 / Katherine M. Leith -- DXI 600 and DXI 800 / Katherine M. Leith -- Elecsys® immunoassay systems / Mary Beth Myers -- PRISM[TM] / Dinesh Shah, Jim Stewart -- Phadia Laboratory Systems / Angela Gore, Gareth Evans, Mats Rilvën -- Immunoassay applications in veterinary diagnostics / Thomas P. O'Connor, Jr. ... [et al.] -- Ligand binding assays in drug development / Jeffrey M. Sailstad ... [et al.] -- Clinical concepts / Chris Davies -- Thyroid / Rhys John ... [et al.] -- The adrenal cortex / Les Perry, Sami Medbak -- Bone and calcium metabolism / William D. Fraser, Kay W. Colston, John C. Stevenson -- Infertility / Michael J. Wheeler -- In vitro fertilization and embryo transfer (IVF-ET) / Richard Fleming, Sherry Faye -- Hirsutism and virilization in the female / Michael J. Wheeler -- Pregnancy / Kevin Spencer, Tim Chard -- Growth and growth hormone deficiency / Gill Rumsby ... [et al.] -- Diabetes mellitus / Penny Clark, Tim McDonald -- Hematology / Katy Evans ... [et al.] -- Cardiac markers / Deborah French, Alan H.B. Wu -- Cancer markers / Hoon H. Sunwoo, Mavanur R. Suresh -- Allergy / Marcos Alcocer, Lars Yman -- Autoimmune disease / David F. Keren -- Gastrointestinal tract / Arne Reseth ... [et al.] -- Hepatitis / Ravi Kaul -- HIV-1 and HIV-2 : causative agents of AIDS / Catherine A. Brennan, Sushil G. Devare -- Viral diseases / Carey-Ann D. Burnham, Christopher Doern, Steven R. Binder -- Bacterial diseases / Carey-Ann D. Burnham, Christopher Doern, Steven R. Binder -- Parasites and fungi / STeven R. Binder, Patrice D. Sarfati -- Therapeutic drug monitoring (TDM) / Philip A. Routledge, Alun D. Hutchings -- Drugs of abuse / Alun D. Hutchings, Brian Widdop.

Machine generated contents note: 1.The Evolution of Immunocytochemistry in the Dissection of Neural Complexity / Laura Lossi -- pt. I Immunocytochemistry in Non-Mammalian Brain -- 2.Immunofluorescence and Genetic Fluorescent Labeling Techniques in the Drosophila Nervous System / Christian Wegener -- 3.Immunohistochemical Analysis of Neuronal Networks in the Nervous System of Octopus vulgaris / Graziano Fiorito -- 4.Genetic Mosaic Labeling and Immunofluorescence Techniques in Zebrafish Brain / Yoshihiro Yoshihara -- pt. II Detection of Cell Proliferation and Neurogenesis -- 5.Immunocytochemical Phenotype of Differentiating Neurons / Antonio Carai -- 6.Immunocytochemical Identification of Mammalian Differentiating Neurons in the Process of Adult Neurogenesis in the Hippocampal Dentate Gyrus / Oliver von Bohlen und Halbach -- 7.Identification of Proliferating and Migrating Cells by BrdU and Other Thymidine Analogs: Benefits and Limitations / Pasko Rakic --

This book presents the timeline of immunodiagnostics evolution, including advancements in immunological/nucleic acid probes, assay design, labelling techniques, and devices for signal transduction and acquisition. In the past few years, enzyme and nanocatalyst-based immune assays have undergone numerous modifications to enhance their sensitivity and potential for automation. Further, to reduce production costs and the use of laboratory animals, engineering small antibodies and nucleic acid probes (aptamers) has become increasingly popular in the development of novel and powerful bioassays. In light of the notable advancements in immunodiagnostics, this book highlights the combined efforts of clinicians, biotechnologists, material scientists, nanotechnologists and basic scientists in a coherent and highly structured way. The book takes readers on the journey of immunodiagnostic technologies, from their introduction to the present.

This textbook focuses on the nascent field of Immunoepidemiology that addresses how differences in immune responses among individuals affect the epidemiology of infectious diseases, cancer, hypersensitivity, and autoimmunity. The idea for the book originated from a course entitled "Immunology for Epidemiologists" at the Yale School of Public Health. While many fine textbooks are available that address the immunological responses of individuals to pathogens, these provided very little information regarding how immunological variation among populations affects the epidemiology of disease. And yet, it has long been recognized that there is great immunologic diversity among people, which can have a profound effect on the epidemiology of disease. Careful review of the immunologic and epidemiologic literature revealed that there have been relatively few publications concerning immunoepidemiology and that no textbook is available on the subject. This textbook therefore aims to fill this void by providing a much-needed tool to comprehensively and efficiently teach immunoepidemiology. The book includes a section on the basic principles of immunology, and then applies them to particular examples of disease in human populations. The target audience for this text book are Masters of Public Health students. Others who should also find it of interest include PhD students in epidemiology, immunology, medical students, generalists, and specialists in immunology, infectious diseases, cancer, and rheumatology.

This book intends to investigate the broad spectrum of genetic changes in immunological processes involved in cutaneous diseases. One of the main goals of immunogenetic studies is finding susceptibility genes for complex diseases. This can provide an insight into the pathogenesis of the condition in a way that is not easily achievable through other kinds of studies. Thus they are a rational initial step for generating hypotheses about disease pathogenesis. This may especially benefit dermatology, a field notorious for having too many diseases with unknown etiologies. Immunogenetic investigations have made targeted treatment strategies possible for diseases such as psoriasis and pemphigus. Even though these strategies have revolutionized the management of chronic dermatological conditions such as psoriasis, still there are a lot of unanswered questions. For instance, psoriasis patients respond very differently to each of the commercially available biological agents. This diversity could be partially explained by the differences in the sets of genes responsible for disease induction in each individual. Thus whole genome sequencing strategies, if feasible at individual levels, might help in tailoring these targeted treatments based on specific genetic backgrounds. Our intention in preparing this book was to explore the broad spectrum of the genetic aspects of immunological processes involved in cutaneous diseases. We have tried to cover most areas of dermatology where enough studies were available to gather a chapter. Still, there is a substantial lack of knowledge on the immunogenetics of many dermatological conditions. We hope that this book would encourage the investigators to fill these gaps of knowledge.

Immunogenicity assay development, validation and implementation / Robert Dodge & Renuka C. Pillutla -- Current regulatory guidelines for immunogenicity assays / Xiao-Yan Cai & Constance Cullen -- New technology and solutions in immunogenicity detection : case studies / Zhandong Don Zhong -- Critical comparison of cell-based assays and immunoassays for neutralizing antibody detection / Renuka C. Pillutla & Robert Dodge -- Drug-tolerant immunogenicity testing / Dharmesh D. Desai -- Good practices for statistical estimation of cut point / Zhandong Don Zhong & Lei Zhou -- Special challenges and considerations for developing assays for the detection of antidrug neutralizing antibodies / Mark A. Kroenke & Shalini Gupta -- Tiered approach to anti-drug antibody testing / Robert Dodge & Heather Myler -- Critical reagent stability for immunogenicity assays / Arron S.L. Xu & Jessica Weant -- Index.

The book covers the basics of genetics and immunology, technical aspects of blood banking and transfusion. It offers a concise, and practical approach for different blood tests and guidelines on the best ways to take donor history, screen donors, store blood components, ensure safety, and anticipate the potentially adverse effects of blood transfusion, components and its management at the bedside. Different chapters include important topics such as collection, storage and transportation of blood, introduction to blood transfusion, blood group serology, discovery of blood groups, donor selection, interview, and its preparation, and storage, pretransfusion testing, transfusion therapy, clinical considerations, and safety, quality assurance, and data management developed specifically for medical technologists and resident doctors. The book also goes beyond preoperative patient blood management, with detailed accounts of coagulation disorder management and the administration of coagulation products and platelet concentrates. The book also defines the components of a learning health system necessary to enable continued improvement in trauma care in both the civilian and the military sectors. This book offers a succinct and user-friendly resource with key points, boxes, tables & charts and is a quick reference guide for pathology and transfusion medicine residents and doctors in blood centers and hospitals dealing with regulatory aspects, transfusion safety, production and storage and donor care.

The latest edition of this volume features an extensively revised and expanded collection of immunohematology and transfusion medicine cases, comprised of clinical vignettes and antibody panels with questions based on each case. Arranged in a workbook format, the text presents cases based on real patient problems that are typically encountered and covers a number of common issues and challenging problems in blood banking and transfusion practice. Discussion and resolution of each case is provided in a separate answer section, including up-to-date information on pertinent advances in the field. This second edition also contains new cases on topics not previously covered, including types of compatibility testing, polyagglutination, hematopoietic stem cell transplantation, immunohematology test drug interference, granulocyte transfusion, heparin-induced thrombocytopenia, and the approach to the bloodless patient. Written by experts in the field, Immunohematology and Transfusion Medicine: A Case Study Approach, Second Edition provides an interactive tool that makes blood banking and transfusion medicine memorable, practical, and relevant to residents and fellows.

Antibodies for Immunochemistry / Mark Cooper, Sheriden Lummas -- The Selection of Reporter Labels / Judith Langenick -- Immunohistochemistry and Immunocytochemistry / Simon Renshaw -- Multiple Immunochemical Staining Techniques / Sofia Koch -- Quality Assurance in Immunochemistry / Peter Jackson, Michael Gandy -- Automated Immunochemistry / Emanuel Schenck, Simon Renshaw -- Confocal Microscopy / Ann Wheeler -- Ultrastructural Immunochemistry / Jeremy Skepper, Janet Powell.

Part I: Immunoinformatics: transition from basic biology to informatics -- 1. A brief outline of the immune system / Namrata Tomar and Rajat K. De -- 2. Crosstalk between the metabolic and immune systems / Namrata Tomar and Rajat K. De -- 3. Immunoinformatics: a brief review / Namrata Tomar and Rajat K. De -- Part II: Databases -- 4. Immunoinformatics of the V, C and G domains: IMGT® definitive system for IG, TR and IgSF, MH and MhSF / Marie-Paule Lefranc -- 5. IMGT/HLA and the immuno polymorphism database / James Robinson, Jason A. Halliwell, and Steven G.E. Marsh -- 6. Databases for T-cell epitopes / Chun-Wei Tung -- 7. Databases for B-cell epitopes / Juan Liu and Wen Zhang -- 8. Antigen-Antibody Interaction Database (AgAbDb): a compendium of antigen-antibody interactions / Urmila Kulkarni-Kale, Snehal Raskar-Renuse, Girija Natekar-Kalantre, and Smita A. Saxena -- 9. Allergen databases / Gaurab Sircar, Debasree Sarkar, Swati Gupta Bhattacharya, and Sudipto Saha -- Part III: Tools for prediction -- 10. Prediction of conformational B-cell epitopes / Wen Zhang, Yanqing Niu, Yi Xiong, and Meng Ke -- 11. Computational prediction of B cell epitopes from antigen sequences / Jianzhao Gao and Lukasz Kurgan -- 12. Machine learning based methods for prediction of linear B-cell epitopes / Hsin-Wei Wang and Tun-Wen Pai -- 13. Mimotope-based prediction of B-cell epitopes / Jian Huang, Bifung He, and Peng Zhou -- 14. Hybrid methods for B-cell epitope prediction: approaches to the development and utilization of computational tools for practical applications / Salvador Eugenio C. Caoili -- 15. Building classifier ensembles for B-cell epitope prediction / Yasser El-Manzalawy and Vasant Honavar -- 16. Multiplex peptide-based B-cell epitope mapping / Sanne M.M. Hensen, Merel Derksen, and Ger J.M. Pruijn -- 17. Classification of Human Leukocyte Antigen (HLA) supertypes / Mingjun Wang and Mogens H. Claesson -- 18. Customized predictions of peptide-MHC binding and T-cell epitopes using EPIMHC / Magdalena Molero-Abraham, Esther M. Lafuente, and Pedro Reche -- 19. T-cell epitope prediction methods: an overview / Dattatraya V. Desai and Urmila Kulkarni-Kale -- 20. Computational antigenic epitope prediction by calculating electrostatic desolvation penalties of protein surfaces / Sebastien Fiorucci and Martin Zacharias -- 21. In silico prediction of allergenic proteins / Gaurab Sircar, Bodhisattwa Saha, Swati Gupta Bhattacharya, and Sudipto Saha -- 22. Prediction of virulence factors using bioinformatics approaches / Rupanjali Chaudhuri and Srinivasan Ramachandran -- Part IV: Systems biology approaches in immunoinformatics -- 23. A systems biology approach to study systemic inflammation / Bor-Sen Chen and Chia-Chou Wu -- 24. Procedures for mucosal immunization and analyses of cellular immune response to candidate HIV vaccines in murine and nonhuman primate models / Shailbala Singh, Pramod Nehete, Patrick Hanley, Bharti Nehete, Guojun Yang, Hong He, Scott M. Anthony, Kimberly Schluns, and K. Jagannadha Sastry -- 25. Immunoinformatics and systems biology in personalized medicine / Guillermo Lopez-Campos, Jesús F. Bermejo-Martin, Raquel Almansa, and Fernando Martin-Sanchez -- Part V: Applications of immunoinformatics -- 26. The role of small RNAs in vaccination / Ajeet Chaudhary and Sunil Kumar Mukherjee -- 27. Structure-based clustering of Major Histocompatibility Complex (MHC) proteins for broad-based T-cell vaccine design / Joo Chuan Tong, Tin Wee Tan, and Shoba Ranganathan -- 28. Immunoinformatics, molecular modeling, and cancer vaccines / Seema Mishra and Subrata Sinha -- 29. Investigating host pathogen behavior and their interaction using genome-scale metabolic network models / Priyanka P. Sadhukhan and Anu Raghunathan -- 30. Mathematical models of HIV replication and pathogenesis / Dominik Wodarz.

Recent years have witnessed numerous advances in stem cell research that have suggested novel strategies for the treatment of the chronic and regenerative diseases that pose a growing challenge to the provision of healthcare in the 21^st century. Nevertheless, there is little doubt that related disciplines have failed to keep pace with such developments, of which the immunology of transplant rejection is perhaps the most relevant to the nascent field of regenerative medicine. Indeed, given that after decades of research into the mechanisms of organ allograft rejection, we remain wholly dependent on immune suppression to ensure acceptance of foreign tissues, we might legitimately ask whether there is any reason why tissues differentiated from stem cells might not suffer the same fate. This volume seeks to address this issue by drawing on the principles of alloantigen recognition to assess the validity of early convictions that embryonic stem cell-derived tissues may prove invisible to the immune system of the host and the more recent belief that induced pluripotent stem cells, derived in a fully autologous manner, will circumvent the issue of immunogenicity. Having debunked such assumptions and established the magnitude of the immunological barriers to be overcome, this book then draws on the expertise of internationally-recognised laboratories around the world to provide a critical assessment of the likely success of applying strategies such as stem cell banking, silencing of genes that confer immunogenicity, and the induction of transplantation tolerance to overcoming the immunological barriers in the future. Indeed, it is only through reaching a consensus in the field that enduring solutions to such an intractable problem may ultimately emerge.

Recent research has revealed the importance of immunological mechanisms and inflammation in delaying damage and/or promoting repair after an acute injury to the central nervous system. This book provides a comprehensive and up-to-date overview of the role of immunological mechanisms and therapies for treating acute neurological injuries such as cerebral ischemia, hemorrhage, and brain and spinal cord trauma. In several sections, the contributing authors provide a review of immunological mechanisms involved in neurological injury and of various translational and clinical research aimed at harnessing those mechanisms for better patient outcomes.

"Immunological Methods in Microbiology, Volume 47 in the Methods in Microbiology series, highlights new advances in the field, with this new volume presenting interesting chapters on Immunological Techniques in the Clinical laboratory, Immunologic Diagnosis of HIV and Opportunistic Infections, Combining Antigen Detection and Serology for the Diagnosis of Selected Infectious Diseases, Immunologic Detection of Lyme Disease and Related Borrelioses, Immunodetection of Bacteria Causing Brucellosis, Immunological Diagnostic Techniques Used to Identify and Type Pasteurella, Immunological Tests for Diarrhea caused by Diarrheagenic Escherichia coli Targeting Their Main Virulence Factors, and much more."--publisher's web page (viewed April 29, 2020)

Introduction to the immune system -- Cells, tissues and organs of the immune system -- Mechanisms of innate immunity -- Complement -- Mononuclear phagocytes in immune defence -- T-cell receptors and major histocompatibility complex molecules -- Antigen presentation -- Cell-mediated cytotoxicity -- B-cell development and the antibody response -- Antibodies -- Immunological tolerance -- Regulation of the immune response -- Immune responses in tissues -- Immunity to viruses -- Immunity to bacteria and fungi -- Immunity to protozoa and worms -- Vaccination -- Primary immunodeficiencies -- Aids, secondary immunodeficiency and immunosuppression -- Autoimmunity and autoimmune disease -- Transplantation and rejection -- Immunity to cancers -- Immediate hypersensitivity (type I) -- Hypersensitivity (type II) -- Hypersensitivity (type III) -- Hypersensitivity (type IV).

"Lippincott® Illustrated Reviews: Immunology, 3e is a relatively new addition to the LIR series. Immunology content was originally covered within the LIR: Microbiology text. However, it eventually became clear that there was demand for a separate text covering immunology content in greater depth. This is especially helpful in med schools where microbiology and immunology are covered separately during basic sciences instruction"-- Provided by publisher.

Psychiatric disorders are one of the most dramatic burdens for humankind. The role of immune dysfunction in the pathophysiology of these disorders has emerged during the last years, because there has been tremendous progress in psychoneuroimmunological research. Many results are presented here by pioneers in the field. The book addresses various effects of the immune system on the pathophysiology and course of psychiatric disorders and highlights the possible future impact on treatment decisions of various psychiatric disorders, including schizophrenia and depression. The contributions cover the role of in utero immune challenges on the development of schizophrenia, the role of infections, and autoimmune diseases and mild immune activation in the development of depression and schizophrenia, the influence of immune responses in other disorders such as Tourette's, Alzheimer's, and OCD, the connections between mental and physical pain as well as between anti-inflammatory and antipsychotic drugs.

1. Introduction to the immune system -- 2. Basic concepts and components of the immune system -- 3. Introduction to the antigen recognition -- 4. Antigens and antibody structure -- 5. Antibody-antigen interaction -- 6. Antibody diversity -- 7. The T-cell receptor -- 8. Major histocompatibility complex -- 9. Review of antigen recognition -- 10. Antigen processing and presentation -- 11. Lymphocyte activation -- 12. Hematopoiesis -- 13. Organs and tissues of the immune system -- 14. B-cell development -- 15. T-cell development -- 16. T-cell interactions and T=cell help -- 17. Immunologic memory and homeostasis -- 18. Regulation of the immune system -- 19. Brief review of immune physiology -- 20. Constitutive defense including complement -- 21. Phagocytes -- 22. Killing in the immune system -- 23. Inflammation -- 24. Cytokines in the immune system -- 25. Infections and vaccines -- 26. Hypersensitivity reactions -- 27. Immediate hypersensitivity (Type I): allergy -- 28. How autoimmune disease develops -- 29. Antibody-mediated hypersensitivity (Type II) -- 30. Immune complex disease (Type III hypersensitivity ) -- 31. Delayed hypersensitivity (Type IV) and review of hypersensitivity reactions -- 32. Primary immunodeficiency -- 33. Primary immunodeficiency -- 33. Secondary immunodeficiency -- 34. Transplantation -- 35. Tumor immunology -- 36. Biopharmaceuticals.

Immunology in the Twentieth Century: From Basic Science to Clinical Application grew out of common knowledge that those who survived many of the common infectious diseases rarely contracted the same disease again. This book charts the historical development of this vital branch of medicine in a concise volume, covering both the basic science involved and the clinical applications. Immunology as a distinctive subject developed in the mid-twentieth century as researchers started to understand how the adaptive immune system aids the defense against pathogens. The subject has grown in importance and diversified into specialist fields, such as immunohistochemistry, immunogenetics and immunopathology.

An Introduction on the old age and aging of the immune system -- The immune system, a marker and modulator of the rate of aging -- Age-associated alterations of pleiotropic stem cell and the therapeutic implication of stem cell therapy in aging -- A role for epigenetic modulation of the innate immune response during aging -- Basophil, eosinophil and neutrophil functions in the elderly -- Dendritic cells and dysregulated immunity in the elderly -- Natural killer cell immunosenescence and cancer in the elderly -- Pattern recognition receptors and aging -- Impact of ageing on T cell repertoire and immunity -- T cell mediated immunity in the immunosenescence process -- Biological and phenotypic alterations of T cells in aging -- T cells seen from the metabolic and aging perspective -- Age-related alterations in regulatory T cells -- Effects of aging on B cells -- The role of MicroRNAs in immunosenescence process -- Immunogenetics of Aging -- Aging immunity and infection -- Influenza infection in the elderly -- Optimising response to vaccination in the elderly -- Nutrition, immunity and aging -- Diet and immunosenescence -- Dietary Intake and impact of zinc supplementation on the immune functions in elderly: nutrigenomic approach -- Physiological and pathological role of reactive oxygen species in the immune cells -- Oxidative stress in aging -- Skin aging and the immune system -- Aging immunity and the impact of physical exercise.

"Cardiovascular immunology is a newly emerging research area, investigating the crosstalk between the cardiovascular and the immune system. This crosstalk is evident through (1) crucial immunological capacities and functions of cardiovascular cell types, including cardiomyocytes, fibroblasts, endothelial cells, pericytes and cardiac resident macrophages, (2) the impact of aberrant immune function on the development of cardiovascular disease such as atherosclerosis, direct and indirect immune-mediated heart disease and vasculitis, and (3) the crucial role of the immune system in cardiac repair and regeneration. The Immunology of Cardiovascular Homeostasis and Pathology covers all these aspects of cardiovascular immunology, starting with homeostatic immunological functions of traditional cardiovascular cell types, and moving then to the role of the immune system in cardiovascular pathology and to recent research into targeting the immune system to boost cardiac healing and regeneration"--Publisher's description.

Fundamentals of immunology: Concepts of innate and specific immunity -- Mucosal immunology -- General immunology of the genital tract: Distinct features of the genital mucosal tissue -- Functions and regulation of innate immune responses in the human reproductive tract -- Functions and regulation of adaptive humoral and cell-mediated immunity in the female genital tract -- Immunization studies -- Immunology of menstruation {u2013} menstruation as an inflammatory process -- Immunology of genital tract infections: Viral infections of the genital tract -- Bacterial infections of the genital tract -- Candidiasis -- Trichomoniasis -- Immunology in reproductive medicine: Immunology of pregnancy -- Immunologic infertility -- Immunocontraceptive approaches.

Immunology of the Lymphatic System is a comprehensive study of the lymphatic system and its immunological role. It begins with lymphatic capillaries, their origin and development. It addresses lymph circulation, in general, with a special emphasis on lymph circulation in parenchymal organs. The next section focuses on lymph nodes, subcortical circulation and the conduit system. It discusses organs with no lymphatic system, such as the brain. Finally, it covers lymph composition and cells in the lymph. While primarily basic research, the volume touches upon elements of the clinical, as well, broadening its scope and appeal.

This book seeks to expand the horizons of vaccine design and discovery by highlighting cutting edge work in three areas of vaccinology: the rational discovery of subunit vaccines, the identification of adjuvants, and the delivery of vaccines via state-of-the-art nanotechnology.

A comprehensive overview of the current research on inflammation and immunopharmacology, with particular attention to the use of anti-inflammatory drugs, this book discusses future trends in this area of pharmacological research. It addresses an audience with basic knowledge in the inflammatory process, immune system, and pharmacology. Immunopharmacology and Inflammation meets the needs of graduate students, junior and senior researchers and is useful as a source of the most current information for those already working in these fields.

"The increasing centralisation of specialised tests and the divorce of clinical and laboratory haematology in many countries means that many haematologists now have no direct contact with an immunophenotyping laboratory. Despite this, the results from the laboratory are often crucial in the management of their patients. This book is intended to help haematologists and trainees to understand and interpret immunophenotyping results. It is not directed at those working in an immunophenotyping laboratory and technical details are therefore outlined only briefly. Such laboratories may, however, find it a useful source of information. For further reading on the subject, see the bibliography of each chapter"-- Provided by publisher.

Introduction to the immune system / Scott McComb ... [et al.] -- Immunoproteomics : current technology and applications / Kelly M. Fulton and Susan M. Twine -- Antigen identification using SEREX / Ugur Sahin and Özlem Türeci -- Antigen discovery using whole-genome phage display libraries / Elisa Beghetto and Nicola Gargano -- Methods and applications of serological proteome analysis / Kelly M. Fulton ... [et al.] -- Pre-absorbed immunoproteomics : a novel method for the detection of bacterial surface proteins / Guangjin Liu, Wei Zhang, and Chengping Lu -- Identification of the antigen content of electroimmunoprecipitates / N. Helena Beyer and Niels H.H. Heegaard -- Immunoproteomics approach to screen the antigenicity of the influenza virus / Kevin M. Downard -- In vivo microbial antigen discovery (InMAD) to identify diagnostic proteins and polysaccharides that are circulating during microbial infections / Sindy J. Chaves ... [et al.] -- Chemo-enzymatic production of O-glycopeptides for the detection of serum glycopeptide antibodies / Alexander Nøstdal and Hans H. Wandall -- Enrichment and characterization of glycopeptide epitopes from complex mixtures / Luc Tessier, Kelly M. Fulton, and Susan M. Twine -- Whole-cell MALDI-TOF mass spectrometry : a tool for immune cell analysis and characterization / Richard Ouedraogo ... [et al.] -- Cell-based arrays for the identification of interacting polypeptide domains or epitopes / Richard H. Maier, Christina J. Maier, and Kamil Önder -- Identification and quantitation of MHC class II-bound peptides from mouse spleen dendritic cells by immunoprecipitation and mass spectrometry analysis / Leonia Bozzacco and Haiqiang Yu -- Construction and screening of an antigen-derived peptide library displayed on yeast cell surface for CD4+ T cell epitope identification / Fei Wen and Huimin Zhao -- Profiling of cytokine and chemokine responses using multiplex bead array technology / Greg Harris and Wangxue Chen -- Preparation of the low molecular weight serum proteome for mass spectrometry analysis / Timothy J. Waybright ... [et al.] -- Identification of protein biomarkers in human serum using iTRAQ and shotgun mass spectrometry / Theodoros A. Koutroukides ... [et al.] -- Genome-based bioinformatic prediction of major histocompatibility complex (MHC) epitopes / Simon J. Foote -- Structure-based prediction of major histocompatibility complex (MHC) epitopes / Andrew J. Bordner -- Prioritization of therapeutic targets of inflammation using proteomics, bioinformatics, and in silico cell-cell interactomics / Arsalan S. Haqqani and Danica B. Stanimirovic -- Commercial considerations for immunoproteomics / Scott M. Ferguson.

Isolation of lipid rafts from human neutrophils by density gradient centrifugation / Carl Fortin and Tamas Fülöp -- Flow cytometry analysis of NK cell phenotype and function in aging / Raquel Tarazona ... [et al.] -- Flow cytometric identification of fibrocytes in the human circulation / Xinyuan Hu, Erin M. DeBiasi, and Erica L. Herzog -- Experimental approaches to tissue injury and repair in advanced age / Aleah L. Brubaker, Stewart R. Carter, and Elizabeth J. Kovacs -- Multicolor digital flow cytometry in human translational immunology / Samit R. Joshi, Subhasis Mohanty, and Albert C. Shaw -- Flow cytometry-based methods to characterize immune senescence in nonhuman primates / Christine Meyer ... [et al.] -- Multiparameter phenotyping of human PBMCs using mass cytometry / Michael D. Leipold, Evan W. Newell, and Holden T. Maecker -- Imaging immunosenescence / Feng Qian and Ruth R. Montgomery -- Activation-induced cytidine deaminase and switched memory B cells as predictors of effective in vivo responses to the influenza vaccine / Daniela Frasca, Alain Diaz, and Bonnie B. Blomberg -- Analyzing the effect of aging on CD8+ T-cell phenotype using flow cytometry / Min Sun Shin and Insoo Kang -- Cell-mediated immune response to influenza using ex vivo stimulation and assays of cytokine and granzyme B responses / Janet E. McElhaney and Beth Gentleman -- Assays for monitoring macroautophagy activity in T cells / Yair Botbol and Fernando Macian -- Fluorescence-based approaches for quantitative assessment of protein carbonylation, protein disulfides, and protein conformation in biological tissues / Asish R. Chaudhuri ... [et al.] -- Monitoring the DNA damage response at dysfunctional telomeres / Rekha Rai and Sandy Chang -- Single-cell analysis of T-cell receptor Αβ repertoire / Pradyot Dash, George C. Wang, and Paul G. Thomas -- Assessment of B cell repertoire in humans / Yu-Chang Wu, David Kipling, and Deborah Dunn-Walters -- Laboratory and data analysis methods for characterization of human B cell repertoires by high-throughput DNA sequencing / Chen Wang ... [et al.] -- Discovery of novel microRNAs in aging Caenorhabditis elegans / Alexandre de Lencastre and Frank Slack -- Analysis of DNA methylation by pyrosequencing / Colin Delaney, Sanjay K. Garg, and Raymond Yung.

This book presents the first multi-disciplinary approach to the understanding of immune aging, or immunosenescence; it combines biological data and clinical observations with psychological, social, and behavioral perspectives and is thus a valuable and timely contribution to the literature in this area. Contributors, all eminent scholars in their respective fields, review thoroughly the state of the art in research that examines how psychological and behavioral factors influence the rate and extent of immune system aging.

Introduction -- Signal amplification for immunosensing -- Electrochemical immunosensing -- Functional nanoprobes for immunosensing -- Chemiluminescent immunoassay -- Electrochemiluminescent immunosensing -- Multianalyte immunoassay -- Fast immunoassay -- Proximity hybridization regulated immunoassay.

Section 1: Background. History of allergen immunotherapy -- Definition of an allergen -- Allergen standardization and manufacturing -- Section 2: Allergic diseases. Allergic respiratory diseases: asthma and allergic rhinitis -- Atopic dermatitis -- Food allergy -- Stinging insects -- Section 3: Mechanisms of allergen immunotherapy. Subcutaneous immunotherapy: aeroallergen -- Sublingual immunotherapy: aeroallergen and venom -- Food tolerance, allergy, and allergen unresponsiveness -- Clinical markers to AIT response -- Biologics for COPD -- Role of biologics in pediatric asthma -- Section 4: Allergen immunotherapy (AIT) and allergen immunomodluatory (AIM) therapies. Breakthroughs in subcutaneous immunotherapy -- Breakthroughs in sublingual immunotherapy -- Food immunotherapy -- Adherence and pharmacoeconomics -- Section 5: AIT and immunomodulatories in investigation. Alternative immunotherapy routes -- Modified allergens: peptides, fragments, and recombinant allergens -- Section 6: Allergen immunomodulatories. Overview of Immunomodulatories -- Anti IGE -- Anti IL5.