Books

In this book, a group of internationally distinguished lymphoma experts provide a comprehensive review of the most important advances in the biology, diagnosis, and therapy of T cell and NK cell malignancies. In particular, it demonstrates in detail how advances in our understanding of the tumor microenvironment and molecular biology have helped to elucidate the pathogenesis of these lymphomas, improve diagnostic and prognostic accuracy, and develop novel therapies that promise improved patient outcomes. Individual chapters are devoted to particular tumor types and subtypes, and all aspects of transplantation for patients with T cell and NK cell lymphomas are discussed. As such, the book offers a valuable resource for hematologists, oncologists, hematopathologists, and all those seeking an up-to-date overview of how new, targeted therapies are delivering better disease control and improved quality of life.

200 million thymocytes and I: A beginner's survival guide to t cell development -- Development of [gamma][delta] T cells, the special-force soldiers of the immune system -- Genetic tools to study T cell development -- Assessment of T cell development by flow cytometry -- Flow cytometry analysis of thymic epithelial cells and their subpopulations -- Identifying the spatial relationships of thymic stromal and thymocyte subsets by immunofluorescence analysis -- Purification of thymocyte and T cell subsets -- Retroviral transduction of T cells and T cell precursors -- Bone marrow and fetal liver radiation chimeras -- In vitro analyses of T cell effector differentiation -- Studying T cell development in thymic slices -- FTOC-based analysis of negative selection -- Reconstituted thymus organ culture -- Induction of T cell development in vitro by delta-like (Dll)-expressing stromal cells -- In vitro analysis of thymocyte signaling -- Molecular analysis of mouse T cell receptor [alpha] and [beta] gene rearrangements -- Intrathymic injection -- Analysis of cell proliferation and homeostasis using EdU labeling -- Characterization and isolation of human T cell progenitors -- Approaches to study human T cell development -- Humanized mice to study human T cell development -- Using the zebrafish model to study T cell development.

The mature T and NK cell lymphomas are rare, comprising approximately 10% of all malignant lymphomas. The incidence of T-cell lymphoma is variable around the world, with a higher incidence compared to B-cell lymphomas in the Asian basin. While the overall incidence of B-cell lymphomas has begun to decline in the United States, the incidence of T-cell lymphomas continues to rise. Over the last decade, a number of novel agents have been developed which target T-cell lymphomas and studies have identified novel genes and pathways associated with lymphomagenesis in T-cells. This comprehensive volume examines the clinical and biological aspects of the T-cell lymphoproliferative disorders in adults and children. The book includes an overview of both the cutaneous and the systemic T-cell malignancies and addresses the classification of T-cell lymphomas, the clinical features of each subtype, and the relevant molecular and genetic studies. Clinical outcomes and treatment strategies are discussed with an emphasis on the development of novel biological and targeted therapies. An outstanding resource for hematologists and oncologists, this book gathers insights from experts in the field and provides the most up-to-date information on all of the T-cell lymphoma subgroups and current and emerging therapies.

Overview of orchestration of CD4+ T cell subsets in immune responses -- Th1/Th2 cell differentiation and molecular signals -- Th1/Th2 cell?s function in immune system -- Regulatory T Cell differentiation and their function in immune regulation -- Th17 differentiation and their pro-inflammation function -- Tfh Cell differentiation and their function in promoting B cell responses -- Differentiation, Regulation and Function of Th9 Cell -- The biology and functions of Th22 cell.

Isolation of T cells from the skin / Beate Lorenz and Esther von Stebut -- Isolation of leukocytes from mouse central nervous system / Iva Lelios and Melanie Greter -- Isolation of T cells from the gut / Sonja Reissig, Christopher Hackenbruch, and Nadine Hövelmeyer -- T cell isolation from mouse kidneys/ Isis Ludwig-Portugall and Christian Kurts -- Intracellular staining for cytokines and transcription factors / Florian Mair and Vinko Tosevski -- Tracking cells and monitoring proliferation / Vinko Tosevski and Florian Mair -- Mass cytometry analysis of human T cell phenotype and function / Evan W. Newell and Lai Li Yun -- Detection of NF-[kappa]B pathway activation in T helper cells / Oliver Gorka, Stefan Wanninger, and Jürgen Ruland -- Assessing the suppressive activity of Foxp3⁺ regulatory T cells / Christian Thomas Mayer and Tim Sparwasser -- In vitro generation of microbe-specific human Th17 cells / Julia M. Braun and Christina E. Zielinski -- In vitro polarization of T-helper cells / Julie Rumble and Benjamin M. Segal -- A method for the generation of TCR retrogenic mice / Elisa Kieback, Ellen Hilgenberg, and Simon Fillatreau -- Mouse models of allergic airway disease / Helen Meyer-Martin, Sebastian Reuter, and Christian Taube -- Induction of colitis in mice (T-cell transfer model) / Benno Weigmann -- Manipulation of T cell function and conditional gene targeting in T cells / Anna Śledzińska,Lynsey Fairbairn, and Thorsten Buch -- Aldara-induced psoriasis-like skin inflammation : Isolation and characterization of cutaneous dendritic cells and innate lymphocytes / C.T. Wohn ... [et al.] -- Induction of passive EAE using myelin-reactive CD4+ T cells / Rhoanne C. McPherson ... [et al.] -- Experimental mouse models of T cell-dependent inflammatory bowel disease / George X. Song-Zhao and Kevin J. Maloy -- Analysis of chromosomal aberrations in murine HCC / Kristian Unger and Mathias Heikenwälder.

This book summarizes the state-of-the art in the development of T cell-based in vitro assays, which offer useful tools for hazard identification, risk assessment and improvement of diagnostics. It will be of interest to scientists, the chemical and pharmaceutical industry, and regulators involved in the replacement of animal testing methods. The identification of hazardous chemicals and drugs is essential to ensuring human health. The ban on animal testing for the cosmetics industry since 2009 and international efforts to reduce and replace animal testing in research and immunotoxicology call for alternative in vitro methods. The most specific immune response to chemicals and drugs that cause allergic contact dermatitis, respiratory disease and adverse drug reactions is the highly antigen-specific T lymphocyte response. Therefore the use of T cells as tools for identifying contact allergens and drugs that may cause health problems is of great interest.

This book addresses one of the major challenges of immunology today that is being directed to the translation of the rapidly emerging volume of basic science contributions of immunology to clinical medicine. In so doing, the book systemically introduces and discusses concepts, classifications, phenotypic and functional descriptions of regulatory T (Treg) cells in health and disease. The authors of the 15 chapters were selected from among the most qualified experts in the field of Treg cell research who provide a comprehensive overview of Treg cells and their biology in the ensuing chapters. The beginning chapters provide a useful contemporary classification of Treg cell populations and then progress to chapters that explore basic mechanisms of Treg cell function and epigenetic control. In addition to descriptions of typical CD4+ Foxp3+ cells, other chapters provide detailed presentations of Treg subsets such as CD8+ Tregs and IL-10-producing Tr1 cells. The differences of various Treg subsets, as well as circulating and resident Treg cell populations, are next compared. Importantly, the next chapters provide the clinical correlation of Treg cells with autoimmune diseases, inflammatory diseases, metabolic diseases, cancer and organ transplantation and progress to chapters that highlight emerging innovative technology including nanoparticle-Treg cells and their translational values. In summary, the book will provide a valuable resource not only for graduate students and researchers in the fields of immunology, cell biology and translational medicine but also for all others interested in learning more about Treg cells and their application in human health and disease.

This book details the advances in cardiac MRI that have enabled quantitative tissue characterization of the myocardium using myocardial and blood T1 measurements, which have enabled reliable detection of diffuse pathological processes in both the cardiomyocytes and the interstitial cells of the myocardium. Evaluation of the native myocardial and interstitial fibrosis, and measurement of the extracellular volume fraction has allowed an unprecedented opportunity to elucidate the pathology, diagnosis and prognosis of cardiovascular disease. T1-Mapping in Myocardial Disease: Principles and Applications reviews a wide spectrum of significant cardiovascular disease and provides relevant guidance for the clinical implementation of this innovative technique. The specific topics covered include principles of T1-mapping in cardiovascular disease and the role of T1-mapping in hypertensive heart disease and hypertrophic cardiomyopathy, cardiotoxicity from cancer treatment, cardiacfibrosis, left ventricular hypertrophy in aortic stenosis, peri-infarct injury in ischemic cardiomyopathy, and stem cell therapy. This comprehensive coverage of the utility of T1-mapping in cardiovascular diseases will greatly appeal to the entire cardiovascular medicine and imaging communities.

I. Geistes-, Nerven-, Augen-, Ohren-, Herz- und Gefässerkrankungen sowie Verdauungsstörungen infolge Tabakmissbrauchs -- II. Der Tabak in gewerbehygienischer Bezichung.

Growth and development -- The orthopaedic history -- The orthopaedic examination : a comprehensive overview -- The orthopaedic examination : clinical application -- Gait analysis -- The limping child -- Back pain -- Disorders of the neck -- Scoliosis -- Kyphosis -- Other anatomic disorders of the spine -- Disorders of the upper extremity -- Developmental dysplasia of the hip -- Legg-calvé-perthes disease -- Slipped capital femoral epiphysis -- Congenital coxa vara -- Disorders of the femur -- Disorders of the leg -- Disorders of the foot -- Limb length discrepancy -- Limb deficiencies -- Arthritis -- Infections of the musculoskeletal system -- General principles of tumor management -- Benign musculoskeletal tumors -- Malignant bone tumors -- General principles of managing orthopaedic injuries -- Spinal injuries -- Upper extremity injuries -- Lower extremity injuries -- Disorders of the brain -- Disorders of the spinal cord -- Poliomyelitis -- Disorders of the peripheral nervous system -- Muscle diseases -- Skeletal dysplasias -- Orthopaedic-related syndromes -- Metabolic and endocrine disorders of bone -- Hematologic disorders -- Pediatric sports medicine : issues in contemporary sports participation.

This state-of-the-art book brings together the full range of issues that can inform care for patients experiencing the effects of concussion. Written by an international panel of experts and edited by a critical care physician and by a cognitive neuroscientist, the book serves as a primer of the various domains of study and application, while providing clinical insights and evidence to bring towards treatment. Chapters span the basic mechanics and pathophysiology of concussion, through its assessment, management, and complications. Comprehensive and timely, this book is accessible to healthcare professionals, and researchers eager to learn something about this field.

"We have a geographically diverse collection of authors who have helped us to present the most important topics in TIVA in a clear and easily readable style. Our vision is to empower readers to start or continue using this technique. Ideally this should be in young, healthy patients undergoing relatively straightforward surgery without the use of muscle relaxants"-- Provided by publisher.

This practical, insightful title is a must read for anyone interested in or recently appointed to a leadership role in an academic medical center. Taking the Lead: A Guide for Emerging Leaders in Academic Medical Centers represents the highly accomplished authors more than 60 years of collective insights about leadership and leading effectively in an academic medical center environment. The authors present creative and highly applicable themes synthesized from their knowledge, career experiences, unique reflections, practice, mistakes, and observations of successful (and not so successful) leaders. The result is a book of leadership wisdom a wealth of ideas, concepts, and insights to inform the readers career journey and to become the best leader they can be. Organized in five parts, this work examines the successful leadership transition in the unique (and sometimes perplexing) academic medical center environment. Informal, conversational in tone, and often engagingly humorous, Taking the Lead: A Guide for Emerging Leaders in Academic Medical Centers represents a concise and invaluable introductory read for the next generation of leaders, as well as a helpful resource for experienced healthcare leaders.

Xanthomonas and the TAL effectors: nature's molecular biologist -- TAL effector DNA-binding principles and specificity -- The development of TALE nucleases for biotechnology -- Online tools for TALEN design -- Assembly of customized TAL effectors through advanced ultimate system -- Engineering customized TALENs using the platinum gate TALEN kit -- Design, assembly, and characterization of TALE-based transcriptional activators and repressors -- A new approach to dissect nuclear organization: TALE-mediated genome visualization (TGV) -- TALEN-induced translocations in human cells -- Mutagenesis in newts: Protocol for Iberian ribbed newts -- Targeted mutagenesis in Bombyx mori using TALENs -- Geneknockout by targeted mutagenesis in a hemimetabolous insect, the two-spotted cricket Gryllus bimaculatus, using TALENs -- Methods for talen evaluation, use, and mutation detection in the mosquito Aedes aegypti -- Methods for TALEN-mediated genomic manipulations in drosophila -- Targeted mutagenesis in zebrafish by TALENs -- Mutagenesis in xenopus and zebrafish using TALENs -- Genome editing in mice using TALE nucleases -- Genome editing in rats using tale nucleases -- Designer nuclease-mediated generation of knockout THP1 cells.

Tamoxifen is a pioneering medicine for the treatment and prevention of breast cancer. It is the first drug targeted therapy in cancer to be successful. Tamoxifen targets the tumor estrogen receptor. The therapy is known to have saved the lives of millions of women over the past 40 years. This monograph, written by V. Craig Jordan - known as the "father of tamoxifen" - and his Tamoxifen Team at the Georgetown University Washington DC, illustrates the journey of this milestone in medicine. It includes a personal interview with V. Craig Jordan about his four decades of discovery in breast cancer research and treatment. V. Craig Jordan was there for the birth of tamoxifen as he is credited for reinventing a "failed morning after contraceptive" to become the "gold standard" for the treatment of breast cancer. He contributed to every aspect of tamoxifen application in therapeutics and all aspects of tamoxifen's pharmacology. He discovered the selective estrogen receptor modulators (SERMs) and explored the new biology of estrogen-induced apoptosis.

Longitudinal imaging and analysis of neurons expressing polyglutamine-expanded proteins / Andrey S. Tsvetkov, D. Michael Ando, and Steven Finkbeiner -- Atomic force microscopy assays for evaluating polyglutamine aggregation in solution and on surfaces / Kathleen A. Burke and Justin Legleiter -- Morphometric analysis of Huntington's disease neurodegeneration in Drosophila / Wan Song ... [et al.] -- Size analysis of polyglutamine protein aggregates using fluorescence detection in an analytical ultracentrifuge / Saskia Polling, Danny M. Hatters, and Yee-Foong Mok -- Method for the incremental expansion of polyglutamine repeats in recombinant proteins / Amy L. Robertson and Stephen P. Bottomley -- Pulse shape analysis (PulSA) to track protein translocalization in cells by flow cytometry : applications for polyglutamine aggregation / Yasmin M. Ramdzan, Rebecca Wood, and Danny M. Hatters -- Characterizing social behavior in genetically targeted mouse models of brain disorders / Emma L. Burrows and Anthony J. Hannan -- PCR amplification and sequence analysis of GC-rich sequences : aristaless-related homeobox example / May H. Tan, Jozef Gécz, and Cheryl Shoubridge -- Challenges of "Sticky" co-immunoprecipitation : polyalanine tract protein-protein interactions / T.R. Mattiske ... [et al.] -- Molecular pathology of polyalanine expansion disorders : new perspectives from mouse models / James N. Hughes and Paul Q. Thomas -- Yeast as a platform to explore polyglutamine toxicity and aggregation / Martin L. Duennwald -- Immuno-based detection assays to quantify distinct mutant huntingtin conformations in biological samples / Gregor P. Lotz and Andreas Weiss -- Modeling and analysis of repeat RNA toxicity in Drosophila / S.E. Samaraweera ... [et al.] -- Analyzing modifiers of protein aggregation in C. elegans by native agarose gel electrophoresis / Mats Holmberg and Ellen A.A. Nollen -- Kinetic analysis of aggregation data / Regina M. Murphy -- Bioinformatics method for identifying Q/N-rich prion-like domains in proteins / Eric D. Ross ... [et al.] -- Detecting soluble polyQ oligomers and investigating their impact on living cells using split-GFP / Patrick Lajoie and Erik Lee Snapp -- Cell biological approaches to investigate polyglutamine-expanded AR metabolism / Lori J. Cooper and Diane E. Merry.

Impact of host factors and comorbid conditions -- Preoperative pulmonary assessment and management of pulmonary complications -- Preoperative cardiac assessment and management of perioperative cardiac complications -- Preoperative hematologic assessment and management of hematologic complications -- Metabolic complications of urologic surgery -- Anesthetic complications in urologic surgery -- Infectious complications of urologic surgery -- Classification of complications and assessment of quality of care -- Complications of the incision and patient positioning -- Management of vascular complications in urology -- Management of bowel complications -- Management of urinary fistula -- Management of urine leak -- Management of ureteral injury -- Management of complications related to traumatic injuries -- Urologic surgery in the obese -- Urologic surgery in the pregnant patient -- Management of complications of gender confirmation surgery -- Complications of genitourinary surgery in the irradiated pelvis -- Prostate biopsy complications -- Complications of upper tract drainage -- Complications of intravesical therapy -- Complications of renal tissue ablation -- Complications of prostate cryosurgical ablation -- Complications of transurethral resection of bladder tumors -- Complications of endoscopic procedures for benign prostatic hyperplasia -- Complications of ureteroscopic surgery -- Complications of percutaneous renal surgery -- Complications of extracorporeal shock wave lithotripsy -- Special considerations in laparoscopy -- Special considerations in robot-assisted surgery -- Complications of robotic-assisted laparoscopic radical prostatectomy -- Complications of robotic pelvic floor reconstruction -- Complications of laparoscopic/robotic nephrectomy and partial nephrectomy -- Complications of robotic upper urinary tract reconstruction -- Complications of robotic cystectomy -- Complications of nephrectomy -- Complications of open partial nephrectomy -- Complications of adrenal surgery -- Complications of lymphadenectomy -- Complications of radical cystectomy and urinary diversion -- Complications of radical retropubic prostatectomy -- Complications of ureteral reconstructive surgery -- Complications of renal transplantation -- Complications of conduit urinary diversion -- Complications of continent cutaneous diversion -- Complications of orthotopic neobladder -- Complications of bladder augmentation and surgery for neurogenic bladder -- Complications of female incontinence surgery -- Complications of surgery for male incontinence -- Complications of urethral reconstruction -- Complications of surgery for erectile dysfunction and peyronie's disease -- Complications of surgery of the testicle, vas deferens, epididymis, and scrotum -- Special considerations in the pediatric patient -- Complications of pediatric endoscopic surgery -- Complications of pediatric laparoscopic and robotic surgery -- Complications of surgery for posterior urethral valves -- Complications of ureteral reimplantation, antireflux surgery, and megaureter repair -- Complications of exstrophy and epispadias repair -- Complications of hypospadias repair -- Complications of surgery for disorders of sex development -- Complications of pediatric urinary diversions and bladder augmentation.

Introduction -- Part I General Post-Mortem Processes: Degradation of Soft Tissue, Bone and Associated Materials -- 1 Gross Post-Mortem Changes in the Human Body -- 2 Microscopic Post-Mortem Changes: the Chemistry of Decomposition -- 3 Profiling Volatile Organic Compounds of Decomposition -- 4 Blood Degradation and Bloodstain Age Estimation -- 5 DNA Degradation: Current Knowledge and Progress in DNA Analysis -- 6 Taphonomic Alterations to Hair and Nail -- 7 Taphonomy of Teeth -- 8 The Taphonomy of Natural Mummies -- 9 Degradation of Clothing in Depositional Environments -- 10 Post-Mortem Interval Estimation: an Overview of Techniques -- Part II The Depositional Environment -- 11 Relationships between Human Remains, Graves and the Depositional Environment -- 12 Bacterial Symbionts and Taphonomic Agents of Humans -- 13 Forensic Entomology and Funerary Archaeoentomology -- 14 Forensic Botany and Stomach Contents Analysis: Established Practice and Innovation -- 15 The Effects of Weathering on Bone Preservation -- 16 The Effects of Terrestrial Mammalian Scavenging and Avian Scavenging on the Body -- 17 Decomposition in Aquatic Environments -- 18 Post-Mortem Differential Preservation and its Utility in Interpreting Forensic and Archaeological Mass Burials -- 19 Reconstructing the Original Arrangement, Organisation and Architecture of Burials in Archaeology -- Part III Anti-, Peri- and Post-Mortem Modifications to the Body -- 20 Forensic Toxicology of Decomposed Human Remains -- 21 Thermal Alteration to the Body -- 22 Concealing the Crime: the Effects of Chemicals on Human Tissues -- 23 Distinguishing between Peri- and Post-Mortem Trauma on Bone -- 24 Collection Care and Management of Human Remains -- Part IV Case Studies -- 25 The Use of Volatile Fatty Acid Biomarkers to Estimate the Post-Mortem Interval -- 26 A Taphonomic Study Based on Observations of 196 Exhumations and 23 Clandestine Burials -- 27 Case Studies on Taphonomic Variation between Cemetery Burials -- 28 Forensic Entomology Case Studies from Mexico -- 29 Recovery of Skeletonised Human Remains and Textile Degradation: a Case Study -- 30 Saponified Brains of the Spanish Civil War -- 31 Analysis and Interpretation of Burned Human Remains from a Homicide -- 32 A Soldier's Story: Forensic Anthropology and Blast Injury -- 33 Decomposition in an Unusual Environment: Body Sealed in Concrete -- 34 A Case Study from Los Angeles: Baby in Concrete -- Part V Past, Present and Future Considerations -- 35 History and Development of the First Anthropology Research Facility, Knoxville, Tennessee -- 36 Crime Scene Investigation, Archaeology and Taphonomy: Reconstructing Activities at Crime Scenes.

This book talks about developing and improvising upon medical presentations by equipping readers with critical technical tips and tricks to use popular presentation programs like PowerPoint or Keynote effectively. The book details numerous remedial measures for qualitative improvement of average medical presentations. It has three sections: first covers the general aspects of preparing a presentation; the second provides practical details and refinements of preparing a medical presentation; the last section deals with niceties of podium and webinar presentations. The chapters cover many serious mistakes and remedial measures to improve average medical presentations, such as a description of purposeful use of colors in a slide, a brief discourse on technicalities of appropriate clinical image formats for projection ensues; the use of drawing and photo-editing programs to inject excellence in the contents of a medical presentation to help it stand out in the crowd, details on the importance of lexical correctness- typography, line spacing and alignment to enhance the impact of the presented text and many more. Several short videos support and actively promote the viewpoints discussed in the text. This book elaborates on the exquisite art of creating remarkable medical presentations for a specialized audience. This book is a must-have for all healthcare professionals of all specialties and grades who make podium presentations in a medical conference webinar or submit posters for display.

The path to oncology drug target validation : an industry perspective -- Identification of aptamers as specific binders and modulators of cell-surface receptor activity -- The design and structure-functional properties of DNA-based immunomodulatory sequences -- SiRNA design principles and off-target effects -- Western blot evaluation of siRNA delivery by ph-responsive peptides -- High-throughput RNAi screening for the identification of novel targets -- Integration of RNAi and small molecule screens to identify targets for drug development -- CellProfiler and KNIME : Open source tools for high content screening -- PARP inhibition as a prototype for synthetic lethal screens -- Structure-based target druggability assessment -- Validating pharmacological disruption of protein-protein interactions by acceptor photobleaching FRET imaging -- Systematic analysis of complex signal transduction pathways using protein fragment complementation assays -- Reverse phase protein microarrays and their utility in drug development -- A cell culture system that mimics chronic lymphocytic leukemia cells microenvironment for drug screening and characterization -- Two-dimensional vs. Three-dimensional in vitro tumor migration and invasion assays -- Tumor spheroid-based migration assays for evaluation of therapeutic agents -- The neurosphere assay applied to neural stem cells and cancer stem cells -- Genetically engineered animal models for in vivo target identification and validation in oncology -- Target validation in mice by constitutive and conditional RNAi -- In vivo target validation by inducible RNAi in human xenograft mouse models -- Bright-field in situ hybridization methods to discover gene amplifications and rearrangements in clinical samples -- Combined microRNA in situ hybridization and immunohistochemical detection of protein markers.

This book introduces readers to intestinal and epidermal barriers, and to toxicity induction of environmental toxicants or stresses in the intestine, epidermis, neurons, muscle, and reproductive organs in Caenorhabditis elegans. In addition, it discusses the protective responses of various organs and nematodes' avoidance behaviour with regard to environmental toxicants or stresses. The intestinal, epidermal, neuronal, and germline signalling pathways required for the regulation of toxicity of environmental toxicants or stresses are also introduced and discussed. As a classic model animal with well-described genetic and developmental backgrounds, the nematode Caenorhabditis elegans has been successfully and widely used in both toxicity assessments and toxicological studies on various environmental toxicants and stresses. Once exposure to certain environmental toxicants has occurred, the toxicants can enter into the primary targeted organs (such as intestinal cells), and even be translocated into secondary targeted organs (such as reproductive organs and neurons). Based on related available data, this book provides a systematic understanding of target organ toxicology in C. elegans.

The main objective of this book is to provide radiation oncologists with a clear, up-to-date guide to tumor delineation and contouring of organs at risk. With this in mind, a detailed overview of recent advances in imaging for radiation treatment planning is presented. Novel concepts for target volume delineation are explained, taking into account the innovations in imaging technology. Special attention is paid to the role of the newer imaging modalities, such as positron emission tomography and diffusion and perfusion magnetic resonance imaging. All of the most important tumor entities treated with radiation therapy are covered in the book. Each chapter is devoted to a particular tumor type and has been written by a recognized expert in that topic.

This handbook is designed to enable radiation oncologists to appropriately and confidently delineate tumor volumes/fields for conformal radiation therapy, including intensity-modulated radiation therapy (IMRT), in patients with commonly encountered cancers.The orientation of this handbook is entirely practical, in that the focus is on the illustration of clinical target volume (CTV) delineation for each major malignancy. Each chapter provides guidelines and concise knowledge on CTV selection for a particular disease, explains how the anatomy of lymphatic drainage shapes the selection of the target volume, and presents detailed illustrations of volumes, slice by slice, on planning CT images. While the emphasis is on target volume delineation for three-dimensional conformal therapy and IMRT, information is also provided on conventional radiation therapy field setup and planning for certain malignancies for which IMRT is not currently suitable.

This practical guide, now in a revised and updated second edition with more clinical cases for different stages, is designed as a concise reference on the delineation of target volumes in radiation oncology. Clear guidance is provided on simulation, setup, and field design for all of the malignancies commonly encountered by practicing radiation oncologists, and slice-by-slice examples are provided for different clinical stages and scenarios. The new edition of this book fully covers modern radiotherapy field design, with inclusion of guidelines on immobilization and simulation for 3D-conformal radiotherapy, intensity-modulated radiation therapy, and stereotactic body radiation therapy. Target Volume Delineation and Field Setup: A Practical Guide for Conformal and Intensity-Modulated Radiation Therapy is written by leading radiation oncologists who provide their expert opinions on all relevant aspects.

This textbook is designed to help the busy radiation oncologist to accurately and confidently delineate tumor volumes for conformal radiation therapy (including IMRT). The book provides an atlas of clinical target volumes (CTVs) for commonly encountered cancers, with each chapter illustrating CTV delineation on a slice-by-slice basis, on planning CT images. Common anatomic variants for each tumor are represented in individual illustrations, with annotations highlighting differences in coverage. The anatomy of each site and patterns of lymphatic drainage are discussed, and their influence on the design of CTVs is explained in detail. Utilization of other imaging modalities, including MRI, to delineate volumes is highlighted. Key details of simulation and planning are briefly reviewed. Although the emphasis is on target volume delineation for conformal techniques, information is also provided on conventional radiation field setup and design when IMRT is not suitable.

Intro; Preface; Contents; 1: Central Nervous System Normal Structures; 1.1 Introduction; 1.2 Visual System; 1.2.1 Lens; 1.2.2 Retina; 1.2.3 Optic Nerves, Chiasm, and Optic Tracts; 1.2.4 Visual Impairment; 1.3 Hypothalamus/Pituitary Gland; 1.4 Temporal Lobe; 1.4.1 Hippocampus; 1.5 Brainstem; 1.6 Temporal Bone: Cochleas; 1.6.1 Ototoxicity; References; 2: Noncentral Nervous System Normal Structures; 2.1 Introduction; 2.2 Head and Neck; 2.2.1 Head and Neck OAR (Fig. 2.1); 2.3 Chest; 2.3.1 Chest OAR (Fig. 2.2); 2.3.1.1 Lungs; 2.3.1.2 Heart Subsegments (Fig. 2.3) 2.3.1.3 Major Vessels2.3.1.4 Ribs and Chest Wall; 2.3.1.5 Brachial Plexus; 2.3.1.6 Spinal Cord; 2.3.1.7 Esophagus; 2.4 Abdomen; 2.4.1 Abdominal OAR (Fig. 2.4); 2.4.1.1 Liver; 2.4.1.2 Kidneys; 2.4.1.3 Bowel; 2.4.1.4 Pancreas; 2.4.1.5 Spleen; 2.5 Pelvis; 2.5.1 Pelvic OAR (Fig. 2.5); 2.6 Extremities; 2.6.1 Extremity OAR (Fig. 2.6); References; 3: Medulloblastoma; 3.1 Background; 3.1.1 Histology; 3.1.2 Staging; 3.1.3 Principles of Management; 3.2 Craniospinal Irradiation Contouring; 3.3 Focal Boosts to Resection Bed Plus Margins in Average-Risk Medulloblastoma 3.4 Whole Posterior Fossa Boosts in High-Risk Medulloblastoma3.5 Metastases; References; 4: Ependymoma; 4.1 Background and Epidemiology; 4.1.1 Pre-radiotherapy Imaging and Evaluation; 4.2 Management and Treatment of Intracranial Childhood Ependymoma; 4.2.1 Intracranial Ependymoma: Principles of Management; 4.2.2 Intracranial Ependymoma (Nondisseminated): General Considerations for Radiotherapy; 4.3 Management and Treatment of Childhood Spinal Ependymoma; 4.3.1 Spinal Cord Ependymoma: Principles of Management; 4.3.2 Spinal Cord Ependymoma: General Considerations for Radiotherapy 4.4 Special Considerations4.4.1 Disseminated Ependymoma; References; Suggested Reading; 5: Pediatric Intracranial Germinomas; 5.1 Introduction; 5.2 Diagnostic Workup, Stratification, and Staging; 5.3 Evolution of Radiation Fields; 5.4 Treatment Paradigm; 5.5 Simulation and Daily Localization; 5.6 Radiation Technique and Target Delineation (See Figs. 5.1, 5.2, 5.3, 5.4, 5.5, 5.6, 5.7, and 5.8); 5.7 Late Toxicity; References; 6: Craniopharyngioma; 6.1 Background; 6.1.1 Epidemiology; 6.1.2 Histologic Subtypes; 6.2 Presenting Findings and Anatomic Relationships; 6.3 Imaging 6.4 Surgery6.5 Radiotherapy; 6.5.1 Radiotherapy Techniques; 6.5.2 Planning and Simulation; 6.5.3 Image Fusion; 6.5.4 Normal Tissue Delineation; 6.5.5 Gross Tumor Volume Delineation; 6.5.6 Clinical Target Volume; 6.5.7 Planning Target Volume; 6.5.7.1 Imaging; 6.5.7.2 Operative Procedure; 6.5.7.3 Radiotherapy Planning; 6.5.7.4 Imaging; References; 7: Gliomas in Children; 7.1 Introduction; 7.2 Background; 7.3 Imaging; 7.4 General Principles; 7.5 Cases; 7.5.1 Juvenile Pilocytic Astrocytoma (JPA); 7.5.2 Low-Grade (Grade 2) Glioma; 7.5.3 High-Grade Glioma

Part I: Overview. Overview of targeted quantitation of biomarkers and its applications / Naidong Weng -- Translational application of biomarkers / Ray Bakhtiar -- Current regulatory guidance pertaining biomarker assay establishment and industrial practice of fit-for-purpose and tiered approach / Naidong Weng -- Modern liquid chromatography and mass spectrometry for targeted biomarker quantitation / Wenying Jian -- Comparison between LC-MS and ligand-binding assay approaches for biomarker quantification / QingQing Wang, Lili Guo, and Ian A. Blair -- Sample preparation methods for targeted biomarker quantification by LC-MS / Shichen Shen, Bo An, and Jun Qu -- Overcome the endogenous levels in biomarker quantitation using LC-MS / Guowen Liu -- Part II: Challenges and approaches. Sample collection for targeted biomarker quantitation by LC-MS / Yuzhong Deng and Xiaorong Liang -- Nonspecific binding in LC-MS bioanalysis / Aimin Tan and John C. Fanaras -- Strategies for improving sensitivity for targeted quantitation by LC-MS / Long Yuan and Qin C. Ji -- Strategies to improve specificity for targeted biomarker quantitation by LC-MS / Yuan-Qing Xia and Jeffrey D. Miller -- Biomarker quantitation using relative approaches / Shane M. Lamos and Katrina E. Wiesner -- Part III: Applications. Targeted quantification of amino acid biomarkers using LC-MS / Barry R. Jones, Raymond F. Biondolillo, and John E. Buckholz -- Targeted quantification of peptide biomarkers: a case study of amyloid peptides / Lieve Dillen, Marc De Meulder, and Tom Verhaeghe -- Targeted protein biomarker quantitation by LC-MS / Yongle Pang, Chuan Shi, and Wenying Jian -- Glycoprotein biomarkers / Shuwei Li, Stefani N. Thomas, and Shuang Yang -- Targeted lipid biomarker quantitation using liquid chromatography-mass spectrometry (LC-MS) / Ashkan Salamatipour, Ian A. Blair, and Clementina Mesaros -- Targeted LC-MS quantification of androgens and estrogens for biomarker development / Daniel Tamae -- Steroid biomarkers / Mike (Qingtao) Huang, Shefali Patel, and Zhongping (John) Lin -- Bile acids as biomarkers / Clara John, Philipp Werner, Joerg Heeren, and Markus Fischer -- Biomarkers for vitamin status and deficiency: LC-MS based approach / Stanley (Weihua) Zhang and Jonathan Crowther -- Quantitation of acyl-coenzyme A thioesters as metabolic biomarkers / Nathaniel Snyder -- Neurotransmitter biomarkers / Guodong Zhang -- Targeted quantification of carbohydrate biomarkers using LC-MS / Cong Wei and Hong Gao -- Nucleoside/nucleotide biomarkers / Guodong Zhang -- LC-MS of RNA biomarkers / Michael G. Bartlett, Babak Basiri, and Ning Li.

This book elaborates on various aspects of targeting via intracellular delivery, specifically through the Receptor Mediated Endocytosis (RME) approach, due to the involvement of cellular receptors in various grave diseases. Targeted delivery relies on two basic approaches, passive and active targeting. While passive targeting approaches have shown great promise, the improved selectivity achieved with active targeting approaches has resulted in significantly higher efficacy. Interestingly there are numerous strategies for active targeting, many of which are already highlighted in Targeted Drug Delivery: Concepts and Applications. Nevertheless an exciting and practical strategy for active targeting, which could enable high intracellular delivery, is through exploitation of RME. Cells in the body express receptors to enable various physiological and biochemical processes. Many of these receptors are overexpressed in pathological conditions, or newer receptors expressed due to defective cellular functioning. RME is based on exploitation of such receptors to achieve intracellular delivery. While targeted delivery can have manifold applications, in this book we focus on two major and challenging therapeutic areas; i) Cancer and ii) Infectious Diseases. Targeted Intracellular Drug Delivery by Receptor Medicated Endocytosis discusses the major receptors that are useful for targeted delivery for these afflictions. An overview of pathways of intracellular uptake is presented with emphasis on RME pathways. A major section of this book is dedicated to details regarding their occurrence and location, the recognition domain of the receptor, structure activity relationship of substrate /ligand for selective binding, ligands explored, antagonists for ligand binding and relevance of these aspects for therapy of cancer and infectious diseases. These facets are elucidated with the help of specific examples from academic research and also clinical trials, wherever relevant. In vitro cellular models relied on for assessing receptor mediated cellular targeting and in vivo models depicting clinical efficacy are focused on in a separate section. This section also includes a chapter on cellular assays which was conceived to provide hands on training to young and nouveau researchers in the field of targeted nanomedicine.

Targeted intraoperative radiotherapy is a major advance in the management of cancer patients and has been attracting massive interest worldwide following publication of the results of an important randomized controlled trial in The Lancet. This textbook is designed to introduce this innovative technology in a comprehensive manner to clinicians dealing with cancer patients. Throughout, the emphasis is on practical aspects, and the text is supported by many excellent illustrations. The editors of the book have extensive experience in targeted intraoperative radiotherapy and include co-directors of the TARGIT Academy, which runs international training courses on the technology in the United Kingdom and Germany. They have brought together multidisciplinary contributors from different centers across the world who have wide experience in the field and whose work has been recognized internationally. It is the editors' hope that this book will succeed in ensuring that targeted intraoperative radiotherapy is used effectively worldwide.

This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patients genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.

This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature. Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.

This book aims to educate nurses and advanced practice providers (APP's) about known mutations, availability of targeted therapy and the management of patients with non-small cell lung cancer (NSCLC). It will educate nurses and practitioners about the scope of therapy to assure safe and effective lung cancer treatment. In this era of personalized medicine, nurses and APP's are responsible for guiding patients from diagnosis through treatment. This starts with the identification of patients that can benefit from these therapies, the key role of biopsy acquisition (ie. what to test, when and how often) and treatment selection based on the mutation identified. Readers will learn about the mechanisms of action, administration, potential adverse side effects and unique management strategies for these targeted agents. Lung cancer continues to be the leading cause of cancer death in the United States and worldwide. Recent advances in the identification of specific oncogenic mutations that drive cancer development, growth and metastasis have led to major paradigm shifts in lung cancer treatment. Sophisticated methods are required to identify specific mutations at the time of diagnosis. This book explains how molecularly targeted therapies have been developed that target these drivers. To date, several tyrosine kinase inhibitors have been approved to target the epidermal growth factor receptor (EGFR), EML4-ALK ,ROS1 and BRAF. Most recently, immune checkpoint inhibitors have been approved with some indication that efficacy may be enhanced for patients who overexpress PD-L1. While some driver mutations have been identified, there is ongoing investigation into additional mutations. In the case of driver mutations, lung cancers will develop resistance to therapy. This book provides nurses and APP's with the mechanisms of resistance that have been identified such as T790 mutation and many others in the EGFR mutation, and shows how the next level of drug development is focused on identifying mechanisms of resistance and development of new agents that overcome these mutations. With this book in hand, nurses and practitioners will be able to navigate patients through this ever expanding field of lung cancer treatment.

This book provides an unprecedented overview of targeted therapies for acute myeloid leukemias. The volume provides comprehensive coverage of the diverse therapeutic strategies that have been developed during the last decade and are now being evaluated in early clinical trials. Authoritative chapters are written by leading research scientists and clinicians, who explain basic concepts and the clinical translation of topics that include the underlying genetic and proteomic abnormalities of AML. The chapter topics include the development of novel nucleoside analogues, the roles of microRNAs, apoptosis regulators Bcl-2 and p53, and of critical cell signaling proteins such as PIM, FLT3, Raf/MEK, PI3K/AKT/mTOR and aurora kinases. In addition, chapters on epigenetic mechanisms, nuclear receptors, cell surface antigens, the hypoxic leukemia microenvironment, stem cells, and leukemia metabolism, provide insight into leukemia cell vulnerabilities. Cell therapies utilizing T-, NK- and mesenchymal stem cells and progress in hematopoietic transplantation strategies complete the overview of the multi-dimensional therapeutic landscape, where leukemia specialists develop treatment strategies, which are expected to bring forth critical breakthroughs in the field of leukemia.

Preface Chapter 1- Colorectal Cancer Subtypes- the current portrait. 1 Peter Jordan Chapter 2- Targeting colon cancers with mutated BRAF and microsatellite instability. 17 Paulo Matos and Peter Jordan Chapter 3 -- Targeting KRAS mutant CMS3 subtype by metabolic inhibitors. 50 Oscar Aguilera and Roberto Serna-Blasco Chapter 4- Targeting the PI3K Signalling as a Therapeutic Strategy in Colorectal Cancer. 77 Maria Sofia Fernandes, João Miguel Sanches and Raquel Seruca Chapter 5- Targeting PTEN in colorectal cancers. 117 Larissa Kotelevets, Mark G.H. Scott and Eric Chastre Chapter 6- Wnt signalling-targeted therapy in the CMS2 tumour subtype: a new paradigm in CRC treatment? 162 Cristina Albuquerque and Lucília Pebre Pereira Chapter 7- Impact of the microenvironment on tumour budding in colorectal cancer. 216 Laurent MC Georges, Laurine Verset, Inti Zlobec, Pieter Demetter, Olivier De Wever Chapter 8- Anti-EGFR Therapy to treat metastatic colorectal cancer: not for all 241 Marta Martins, André Mansinho, Raquel Duarte, Soraia Lobo Martins and Luís Costa Chapter 9- miRNAs as modulators of EGFR therapy in colorectal cancer. 282 Diane M. Pereira and Cecília M. P. Rodrigues Index.

Autophagy as a Therapeutic Target in Cancer.-Autophagy in Cancer Cells vs Cancer Tissues: two different stories -- Small-Molecule Regulators of Autophagy as Potential Anti-Cancer Therapy -- Regulation of autophagy by microRNAs: Implications in cancer therapy -- Targeting PI3-kinases in modulating autophagy and anti-cancer therapy -- Adult and Cancer Stem Cells:Perspectives on Autophagic Fate Determinations and Molecular Intervention -- Role of autophagy in tumor progression and regression.

This book offers a much-needed discussion on the targeting of biofilm-related infections. Chapters include discussions on the impact of biofilm on medical implants, industrial applications, as well as wound and tissue infections. It also offers discussions on regulatory management for industrial sectors and medical environments. Given that there continues to be a paucity of effective antimicrobial products, devices, and coatings in clinical and industrial use that effectively reduce rates of infection or biofilm-related problems, Targeting Biofilms in Translational Research, Device Development, and Industrial Sectors, offers a fresh and much-needed perspective aimed at helping create healthier controlled environments and safer devices. This comprehensive book is indispensable for industrial and academic translational researchers, device developers, and regulatory experts looking to create more effective antimicrobial products.

The 81st Cold Spring Harbor Symposium focused on Targeting Cancer. The implications of how the underlying science can drive improvements in diagnostic, prognostic, and therapeutic approaches was a major theme throughout the Symposium. The topics covered at the meeting included: Cancer Genes and Genomes; Cancer Pathways; Tumor Cell Biology; Cancer Growth & Progression; Innate & Adaptive Immune Responses; and Enabling Technologies. Several speakers participated in interviews during the course of the Symposium week and transcripts of those videos and the Dorcas Cummings lecture are included.

Targeting carbonic anhydrases / Clemente Capasso & Claudiu T. Supuran -- Overview of carbonic anhydrase families/isoforms / Clemente Capasso & Claudiu T. Supuran -- Classical sulfonamides and their bioisosters as carbonic anhydrase inhibitors / Jean-Yves Winum -- Next-generation primary sulfonamide carbonic anhydrase inhibitors / Suleyman Akocak & Marc A. Ilies -- Next-generation secondary/tertiary sulfonamide carbonic anhydrase inhibitors / Sébastien Thibaudeau, Hélène Carreyre, Agnès Mingot & Claudiu T. Supuran -- Next-generation polyamine human carbonic anhydrase inhibitors / Fabrizio Carta & Andrea Scozzafava -- Next-generation phenol carbonic anhydrase inhibitors / Pedro Alfonso Colinas -- Coumarins that inhibit carbonic anhydrase / Sally-Ann Poulsen -- Next-generation dithiocarbamate carbonic anhydrase inhibitors / Fabrizio Carta, Murat Bozdag, Muhammet Tanc & Claudiu T. Supuran -- Protozoan, fungal and bacterial carbonic anhydrases targeting for obtaining anti-infectives / Clemente Capasso & Claudiu T. Supuran -- Amine, amino acid and oligopeptide carbonic anhydrase activators / Giuseppina De Simone, Clemente Capasso & Claudiu T. Supuran -- Targeting carbonic anhydrases in biotechnology / Clemente Capasso & Claudiu T. Supuran.

Intro; Contents; Contributors; 1 An Introduction to the Book; Abstract; 2 Chitin: Structure, Chemistry and Biology; Abstract; 2.1 Introduction; 2.2 Chemistry; 2.3 Chemistry to Structure; 2.4 Structure to Biology; 2.5 Concluding Remarks; Acknowledgements; References; 3 Chitin Prevalence and Function in Bacteria, Fungi and Protists; Abstract; 3.1 Introduction; 3.2 Bacteria that Produce Chitin Oligosaccharides; 3.2.1 Nodulation Genes and Their Functions in Establishing Rhizobia-Legume Symbiosis; 3.3 Recognition of LCOs by Host Receptors 3.4 Fungi that Deposit Chitin (and Chitosan) as a Component of Cell (and Spore) Walls3.5 Cell and Spore Wall Structure in Fungi; 3.5.1 Structure and Regulation of the Chitin Synthase in Fungi; 3.5.2 Evolution and Classification of Fungal CHS Genes; 3.5.3 Chitin as a Target for the Immune System and Its Function in Pathogenicity and Symbiosis; 3.6 Chitin in Protists; 3.7 Methods Used for Chitin Detection in Protists; 3.8 Occurrence of Chitin in Protists; 3.9 Chitin in Pathogenic Protists; 3.10 Chitin Formation in Heterokont and Archaeplastidal Algae; 3.11 Conclusions; References 4.3.2.3 PRRs in Other Species4.3.3 Relevant Signal Transduction Pathways Involved in Chitin Perception; 4.3.3.1 Chitin-Induced Signal Transduction in Arabidopsis; AtPBL27; AtBIK1; 4.3.3.2 Chitin-Induced Signal Transduction in Rice; OsRLCK185; OsRac1; OsBSR1; 4.4 Concluding Remarks; References; 5 Chitin Organizing and Modifying Enzymes and Proteins Involved In Remodeling of the Insect Cuticle; Abstract; 5.1 Introduction; 5.2 Chitin Synthases, the Enzymes that Polymerize Precursors of Chitin; 5.2.1 A Mechanistic View on Chitin Synthesis, Translocation and Fibrillogenesis 5.2.2 Specialization Among CHS Isoforms5.3 Chitinases; 5.3.1 Group I Chitinases; 5.3.2 Group II Chitinases; 5.3.3 Group III Chitinases; 5.3.4 TEM Analyses of Cuticle; 5.3.5 Group IV Chitinases; 5.3.6 Group V Chitinases; 5.3.7 Group VI Chitinases; 5.3.8 Other Chitinase Families; 5.4 N-acetylglucosaminidases; 5.5 Molting Fluid-Associated Chitinolytic Enzymes; 5.6 Chitin Deacetylases (CDAs); 5.6.1 Arthropod/Insect CDAs; 5.7 Chitin-Remodeling Proteins; 5.7.1 Knickkopf Family of Proteins; 5.7.2 CPAP Proteins; 5.7.3 Peritrophic Matrix Proteins (PMPs); 5.7.4 CPR Family Proteins

The serendipitously discovered link between developmental biology and cancer, touched of an explosion of discoveries on the role of Notch in human malignancies, including every aspect of cancer biology, from control of differentiation, proliferation and apoptosis in transformed cells to angiogenesis, tumor-stroma interaction and anti-cancer immune responses. A number of observations have revealed that Notch even plays a role in the renewal of cancer stem cells and tumor initiating cells, which are thought to be a major cause of resistance to treatment. Targeting Notch in Cancer will provide researchers, oncologists, pharmacologists and students with a detailed understanding of the intricate cross-talk between Notch and other pathways of therapeutic interest so to better design rational drug combinations for specific diseases and disease subsets. Divided into two parts, Part I describes in detail what we know about the genetics, molecular biology, biochemistry and structural biology of Notch, as well as the role of Notch in such processes as angiogenesis and immune surveillance. Without insights gained from these basic studies, rational targeting of Notch in human disease would be impossible. Part II describes the role of Notch and ongoing experimental therapeutic efforts in the most important subtypes of human cancers, organized in a clinically oriented fashion by organs and systems affected.

Epidemiology and Management: Epidemiology -- Emerging Role of HPV -- Management of Oral Cancer. Development and Biomarkers: Molecular Progression and Signaling -- Stem Cells and Tumor Development -- Prognostic/Predictive Biomarkers -- EIF4e as Biomarker and Target. Breaking Developments and New Drug Discovery: Current Clinical Trials -- Emerging Drug Targets -- Targeting the UPR -- Targeting Meditators of Coagulation -- Resveratrol Pre-Sensitizing -- Academic High Throughput Drug Discovery.

This book provides an overview of the discovery and structure of IL-17, including its pathogenesis and role in chronic inflammation and autoimmunity. To capture the latest developments and product approvals the book also discusses the therapeutic advances and looks at emerging therapies targeting the IL-17 pathway. IL-17 is a pro-inflammatory cytokine that has a key role in inflammation, autoimmunity, and host defense in a number of inflammatory disorders such as rheumatoid arthritis, psoriatic arthritis and psoriasis, ankylosing spondylitis, multiple sclerosis, and inflammatory bowel disease. The discovery of the IL-17-Th17 pathway has seen exciting development in the field of immunology and inflammation research, which has led to a number of recent regulatory approvals.

Preface -- The tattooed and the social environment. The cultural heritage of tattooing: a brief history -- Epidemiology of tattoos in industrialized countries -- The practise of tattooing. Tattoo machines, needles and utilities -- The technique and craftsmanship of tattooing in the professional tattoo parlour -- Tattoo as art, the drivers behind the fascination and the decision to become tattooed -- Personal records from my tattoo parlour: deep emotions drawn as life-long pictures on the skin's canvas -- Tattooist-customer relationships in a diversified environment of professional tattooists and 'scratchers' -- Tattoos and adverse events. Tattoo complaints and complications: diagnosis and clinical spectrum -- Complications of cosmetic tattoos -- Chronic tattoo reactions cause reduced quality of life equaling cumbersome skin diseases -- Contraindications for tattooing -- Laser tattoo removal, precautions, and unwanted effects -- Nano-scale observations of tattoo pigments in skin by atomic force microscopy -- Manufacturing, materials and properties of marketed tattoo ink stock products. Manufacturing of tattoo ink products today and in future -- The realistic variables underlying true safety in tattoo pigment manufacturing -- Making innovative tattoo ink products with improved safety: possible and impossible ingredients in practical usage -- Tailored surface engineering of pigments by layer-by-layer coating -- Ingredients, chemical analysis and safety of marketed tattoo ink stock products. Chemical purity and toxicology of pigments used in tattoo inks -- Survey on european studies of the chemical characterisation of tattoo ink products and the measurement of potentially harmful ingredients -- Tattoo inks: legislation, pigments, metals and chemical analysis -- The challenges and limitations of chemical analysis of particulate pigments of very low solubility -- Photostability and breakdown products of pigments currently used in tattoo inks -- Carbon black nanoparticles and other problematic constituents of black ink and their potential to harm tattooed humans -- Absorption, distribution, metabolism and excretion of tattoo colorants and ingredients in mouse and man: the known and the unknown -- Towards the limiting of health risks associated with tattooing: whitelists for tattoo pigments and preservatives -- Survey of studies on microbial contamination of marketed tattoo inks -- Regulation of and intervention in the tattoo business. The European landscape of national regulations of tattoo inks and businesses -- Implementation of European Council Resolution ResAP(2008)1 in Italy. National and regional regulation of tattoo practices: diversity and challenges -- EU actions to ensure the safety of tattoos and the protection of consumers -- Surveillance of tattoo-related adverse events by the EU RAPEX System and by national monitoring -- The Amsterdam model for control of tattoo parlours and businesses -- Hygiene standards for tattooists -- Hygiene standards in the tattoo parlour and practices for prevention of infection -- Seamless prevention of adverse events from tattooing: integrated strategy emphasising the customer-tattooist interaction -- Regulation of tattoo ink production and the tattoo business.

This book presents essential studies and cutting-edge research results on tau, which is attracting increasing interest as a target for the treatment of Alzheimer's disease. Tau is well known as a microtubule-associated protein that is predominantly localized in the axons of neurons. In various forms of brain disease, neuronal loss occurs, with deposition of hyperphosphorylated tau in the remaining neurons. Important questions remain regarding the way in which tau forms hyperphosphorylated and fibrillar deposits in neurons, and whether tau aggregation represents the toxic pathway leading to neuronal death. With the help of new technologies, researchers are now solving these long-standing questions. In this book, readers will find the latest expert knowledge on all aspects of tau biology, including the structure and role of the tau molecule, tau localization and function, the pathology, drivers, and markers of tauopathies, tau aggregation, and treatments targeting tau. Tau Biology will be an invaluable source of information and fresh ideas for those involved in the development of more effective therapies and for all who seek a better understanding of the biology of the aging brain.

Volume 1. The Nervous system, immune system, diabetes and the cardiovascular system -- Volume 2. Nutrition and metabolism, protective role, and role in reproduction, development, and differientiation.

Taurine 9 contains original articles and critical reviews based on the oral and poster presentations of XIX International Taurine Meeting held in Kraków, Poland in May 2014. The purpose of the book is to present current ideas, new avenues and research regarding biological functions and clinical applications of taurine and taurine derivatives. It focuses on all aspects of taurine research including the cardiovascular system, the immune system, diabetes, the central nervous system, endocrine system and the role of taurine supplements in nutrition. It also includes presentations of novel animal experimental models using Cdo1 and CSAD knock-out mice.

This book provides comprehensive, authoritative descriptions of the microbes involved in cleaning up oil spills and degrading climate-altering hydrocarbons such as methane, and has detailed discussions about the taxonomy, ecology, genomics, physiology and global significance of these hydrocarbon-degrading microbes.

A history of pediatric ophthalmology and strabismus -- Epidemiology and the worldwide impact of visual impairment in children -- Clinical embryology and development of the eye -- Developmental biology of the eye -- Clinical aspects of normal and abnormal visual development and delayed visual maturation -- Milestones and normative data -- Examination, history and special tests in pediatric ophthalmology -- Managing refractive errors in children -- Visual electrophysiology : how it can help you and your patient -- Imaging the child's eye, orbit, and visual pathways -- Genetics and pediatric ophthalmology -- Congenital infections of the eye -- Conjunctivitis of the newborn -- Preseptal and orbital cellulitis -- Endophthalmitis -- External eye disease and the oculocutaneous disorders -- Ocular manifestations of hiv/aids in children -- Disorders of the eye as a whole -- Lids : congenital and acquired abnormalities ? practical management -- Lid and orbital infantile periocular hemangiomas (capillary hemangiomas) and other vascular diseases -- Lacrimal system -- The management of orbital disease in children -- Neurogenic tumors -- Orbital rhabdomyosarcoma -- Other mesenchymal abnormalities -- Metastatic, secondary and lacrimal gland tumors -- Histiocytic, hematopoietic, and lymphoproliferative disorders -- Craniofacial abnormalities -- Cystic lesions and ectopias -- Inflammatory disorders -- Conjunctiva and subconjunctival tissue -- Conjunctival tumors -- Anterior segment developmental anomalies including aniridia -- Corneal abnormalities in childhood -- Corneal dystrophies -- The lens -- Childhood cataracts -- Childhood glaucoma -- Pediatric iris disorders -- Uveitis -- Albinism -- Vitreous -- Retinoblastoma -- Retinopathy of prematurity -- Current treatment of retinopathy of prematurity -- Inherited retinal disorders -- Retinal dystrophies with systemic associations and the retinal ciliopathies -- Inherited macular dystrophies -- Congenital pigmentary and vascular abnormalities of the retina -- Retinal flecks, dots and crystals -- Acquired and other retinal diseases (including juvenile x-linked retinoschisis) -- Retinal detachment in childhood -- Congenital anomalies of the optic discs -- Hereditary optic neuropathies -- Other acquired optic disc abnormalities in children -- Demyelinating, inflammatory, infectious, and infiltrative optic neuropathies -- The optic chiasm -- Headache in children -- Raised intracranial pressure -- The brain and cerebral visual impairment -- Delivering bad news -- Common issues arising in children with visual impairment -- Visual conversion disorders : fabricated or exaggerated symptoms in children -- Dyslexia -- Neurometabolic disease and the eye -- Pupil anomalies and reactions -- Leukemia -- Phakomatoses (including the neurofibromatoses) -- Accidental trauma in children -- Child maltreatment, abusive head trauma, and the eye -- Refractive surgery in children -- Binocular vision -- Amblyopia : basics, questions, and practical management -- Anatomy of strabismus -- The orthoptic evaluation -- Infantile esotropias -- Accommodative esotropias -- Special esotropias (acute comitant, sensory deprivation, myopia-associated and microtropia) -- Intermittent exotropia -- Special forms of comitant exotropia -- Vertical strabismus -- "a," "v," and other pattern strabismus -- Congenital cranial dysinnervation disorders -- Ocular motor nerve palsies -- Strabismus : nonsurgical treatment -- Strabismus surgery -- Minimally invasive strabismus surgery -- Strabismus surgery complications and how to avoid them -- Nystagmus in childhood -- Supranuclear eye movement disorders, acquired and neurologic nystagmus -- "I think my baby can't see!" -- "My baby's got a red eye, doctor!" -- "My child keeps blinking and closing his eye" -- "M child seems to hate the bright light" -- "M child's eyes keep watering!" -- Proptosis at different ages -- "M child's teacher says she can't see properly!" -- "M child could see perfectly but now the vision is weak!" -- The child with a dual sensory loss (deafblind) -- "M little girl tells me she sees strange things" -- Wobbly eyes in infancy -- Abnormal head postures in children -- Hand defects and the eye -- Optimizing compliance in patching therapy -- Vision screening -- Self-inflicted ocular injuries -- Apps and all that ? (how my smartphone changed my life).

Skin of color : a historical perspective -- Defining skin of color -- Epidemiology of cutaneous diseases -- Multicultural competence in dermatologic practice -- The impact of traditional cultures on health care practices : an overview -- The impact of traditional African American cultures on heath care practices -- The impact of traditional Asian cultures on health care practices -- The impact of traditional Hispanic cultures on health care practices -- The impact of traditional Arabian Gulf cultures on health care practices -- Psychiatric aspects of skin of color -- The structure and function of skin of color -- Histology -- Genetics of skin diseases -- Biology of hair follicles -- Biology of nails -- Biology of the oral mucosa -- Biology of wounds and wound care -- Acute effects of light on the skin -- Chronic effects of light on the skin -- Nuances of skin of color -- Skin lesions : normal and pathologic -- Dermatosis papulosa nigra -- Seborrheic dermatitis -- Psoriasis -- Pityriasis rosea -- Lichen planus and lichen nitidus -- Atopic dermatitis and other eczemas -- Allergic contact dermatitis -- Photosensitivity -- Erythema chronicum perstans and related disorders -- Amyloidosis -- Acquired bullous diseases.

"Taylor's Differential Diagnosis manual is a quick-reference pocket book, written for primary care professionals who face diagnostic problems in brief office visits. It offers evidence-based guidelines on which key questions to ask and what data to obtain in order to provide sound diagnoses of common adult problems. More than 140 chapters in eighteen sections cover symptoms and signs in mental health problems, vision, ear nose and throat, cardiovascular, respiratory, urologic, female reproductive, musculoskeletal, dermatology and more. New for this edition are new chapters on abnormal mammogram, anticoagulation, bipolar disorder, corneal abrasion, dyspareunia and loss of vision as well as the latest clinical evidence and changes in clinical practice since the prior edition"--Provided by publisher.

How to use this text to pass -- Test taking strategies -- Special considerations -- Clinical practice : head and neck -- Clinical practice : trunk -- Clinical practice : extremity and wound -- Continuum of care for trauma -- Professional issues -- Environmental & pharmacology -- Special populations : pediatric, geriatric, bariatric -- Special populations : obstetrical, newborn.

This book highlights the role of the Translationally Controlled Tumor Protein (TCTP) in cell signaling, cell fate and the resulting connection to disease development. It begins by discussing the structure/function of TCTP, before exploring its role in different species ranging from plants to Drosophila and covering fields such as development, the cytoskeleton, cell division, DNA fragility and apoptosis. In turn, the book's final section is devoted to the role of TCTP in disease, namely asthma and diverse cancers, and ultimately as a target for the treatment of malignancies. What is the common denominator between all these processes and why is TCTP necessary in order for them to occur, even in the worst case such as cancer? The book seeks to provide meaningful answers to this and other key questions. Presenting a broad and revealing view on the topic, it offers an informative guide for scientists and students alike.

Operative gynecology before the era of laparoscopy: a brief history -- The ethics of pelvic surgery -- Psychological aspects of pelvic surgery -- Risk prevention, risk management, and professional liability -- The changing environment in which we practice gynecologic surgery -- Training the gynecologic surgeon: maintaining and improving surgical skills -- Surgical anatomy of the female pelvis -- Preoperative care of the gynecologic patient -- Postanesthesia and postoperative care -- Water, electrolyte, and acid-base metabolism -- Postoperative infections: prevention and management -- Shock in the gynecologic patient -- Wound healing suture material, and surgical instrumentation -- Incisions for gynecologic surgery -- Principles of electrosurgery and laser energy applied to gynecologic surgery -- Diagnostic and operative laparoscopy -- Robotic surgery -- Operative hysteroscopy -- Control of pelvic hemorrhage -- The impact of assisted reproductive technology on gynecologic surgery -- Reconstructive tubal surgery -- Endometriosis -- Surgical conditions of the vulva -- Surgical conditions of the vagina and urethra -- Surgery for anomalies of the müllerian ducts -- Normal and abnormal uterine bleeding -- Tubal sterilization -- Surgery of benign disease of the ovary -- Persistent or chronic pelvic pain -- Pelvic inflammatory disease -- Leiomyomata uteri and myomectomy -- Abdominal hysterectomy -- Vaginal hysterectomy -- Laparoscopic hysterectomy -- Management of abortion -- Ectopic pregnancy -- Surgical management of obstetric complications -- Ovarian tumors complicating pregnancy -- Pelvic organ prolapse: basic principles -- Reconstruction of the anterior vagina for prolapse -- Posterior compartment defects -- Vaginal vault prolapse -- Nonsurgical management of pelvic organ prolapse: the use of vaginal pessaries and pelvic floor muscle training -- Stress urinary incontinence -- Operative injuries to the ureter -- Vesicovaginal and urethrovaginal fistulas -- Anal incontinence and rectovaginal fistula -- Diseases of the breast -- The verminform appendix in relation to gynecology -- Intestinal surgery for the gynecologic surgeon -- Nongynecologic conditions encountered by the gynecologic surgeon -- Malignancies of the vulva -- Cervical cancer precursors and their management -- Cancer of the cervix -- Endometerial cancer -- Ovarian cancer -- Pelvic extenteration -- Surgical reconstruction of the pelvis in gynecologic cancer patients.

Section I Preparing for Surgery: Surgical anatomy of the female pelvis -- Preoperative care of the gynecologic patient -- Section II Principles of Gynecologic Surgery: Anesthesia primer for the gynecologist -- Patient positioning for pelvic surgery -- Surgical techniques, instruments, and suture -- Incisions for gynecologic surgery -- Surgical control of pelvic hemorrhage -- Principles of laparoscopy -- Principles of robotic surgery -- Section III Perioperative and Postoperative Care of the Gynecologic Patient: Postoperative care of the gynecologic patient -- Section IV Contemporary Gynecologic Surgical Procedures -- Dilation and curettage -- Hysteroscopy -- Surgical management of abortion and its complications -- Surgery for benign vulvar conditions -- Tubal sterilization -- Surgery of the ovary and fallopian tube -- Myomectomy -- Vaginal hysterectomy -- Abdominal hysterectomy -- Laparoscopic and robotic-assisted hysterectomy -- Section V: Gynecologic Oncology -- Section VI: Surgery for Pelvic Floor Disorders -- Section VII: Management of Selected Gynecologic Conditions -- Section VIII: Surgery for Obstetrical Complications.

Teaching Anatomy: A Practical Guide is the first book designed to provide highly practical advice to both novice and experienced gross anatomy teachers. The volume provides a theoretical foundation of adult learning and basic anatomy education and includes chapters focusing on specific issues that teachers commonly encounter in the diverse and challenging scenarios in which they teach. The book is designed to allow teachers to adopt a student-centered approach and to be able to give their students an effective and efficient overall learning experience. Teachers of gross anatomy and other basic sciences in undergraduate healthcare programs will find in this unique volume invaluable information presented in a problem-oriented, succinct, and user-friendly format. Developed by renowned, expert authors, the chapters are written concisely and in simple language, and a wealth of text boxes are provided to bring out key points, to stimulate reflection on the reader?s own situation, and to provide additional practical tips. Educational theories are selectively included to explain the theoretical foundation underlying practical suggestions, so that teachers can appropriately modify the strategies described in the book to fit their own educational environments. Comprehensive and a significant contribution to the literature, Teaching Anatomy: A Practical Guide is an indispensable resource for all instructors in gross anatomy.

This book considers the evolution of medical education over the centuries, presents various theories and principles of learning, and discusses different forms of medical curriculum and the strategies employed to develop them, citing examples from medical schools in developed and developing nations. Instructional methodologies and tools for assessment and evaluation are discussed at length and additional elements of modern medical teaching, such as writing skills, communication skills, evidence based medicine, medical ethics, skill labs, and webinars, are fully considered. In discussing these topics, the authors draw upon the personal experience that they have gained in learning, teaching and disseminating knowledge in many parts of the world over the past four decades. .

Clinical reasoning and diagnostic error / Robert L. Trowbridge Jr., Mark L. Graber -- Theoretical concepts to consider in providing clinical reasoning instruction / Temple A. Ratcliffe, Steven J. Durning -- Developing a curriculum in clinical reasoning / Joseph J. Rencic, Robert L. Trowbridge Jr., Steven J. Durning -- Educational approaches to common cognitive errors / James B. Reilly -- General teaching techniques / Cynthia H. Ledford, L. James Nixon -- Assessment of clinical reasoning / Valerie J. Lang, Lambert Schuwirth, Joseph J. Rencic, Steven J. Durning -- Faculty development and dissemination / Jennifer R. Kogan, Eric Holmboe -- Lifelong learning in clinical reasoning / Gurpreet Dhaliwal -- Remediation of clinical reasoning / Michael Elnicki, Joan M. von Feldt -- Novel approaches and future directions / Jeffrey S. La Rochelle, Anthony R. Artino, Dario M. Torre -- Afterword : teaching clinical reasoning : where do we go from here? / Steven J. Durning, Joseph J. Rencic, Lambert Schuwirth, Robert L. Trowbridge Jr.

Practicing evidence-based medicine is widely regarded both as best clinical practice, and as the cornerstone of meeting the ACGME competencies in Practice-Based Learning and Improvement. Training programs recognize the need to teach the skills of EBM and yet struggle with readily available content and guidance on putting together a curriculum. Time frames for delivering curricula in residency can be very tight, often restricted to scattered one hour conferences. This book provides a modular curriculum structure for instructors, with each topic area taking up one section, or one hour of instructional time. Developed over the past 14 years as an introductory course for interns in the internal medicine residency program at Duke, the curriculum will cover core content areas in evidence-based medicine and best teaching practices for them and skills such as literature searching and applying evidence to patients. Most importantly, it will center on actual patient questions and use current literature as examples that instructors can use as teaching exercises. There will also be ample diagrams that have been shown to be effective with learners and each module will include a video tutorial of a sample teaching session, including visual aids and small group teaching techniques. The curriculum can be implemented in any time frame necessary, compressed or longitudinal, to a variety of learners. This is an ideal guide for residency program directors and core faculty, either within internal medicine or more broadly in family medicine, pediatrics, surgery, OB-gyn, as well as medical school faculty for use with students.

Teaching medicine -- Meet the attending -- Building the team -- A safe, supportive environment -- Bedside and beyond -- How to think about thinking -- Role models -- The sacred act of healing -- Putting it all together.

This book uses real-world clinical case analyses of hot topics to provide insights into noninvasive mechanical ventilation (NIV). Written by leading international teachers and experts, it features a selection of "major controversial topics in clinical practice" and demonstrates how these cases can be used to teach about NIV. It then presents a discussion of the topics in various scenarios (anesthesiology, critical care, emergency and pneumology). The chapters allow readers to develop a case-by-case understanding of NIV in acute and chronic respiratory disorders, and perioperative and in intensive care patients, also thanks to Electronic Supplementary Materials. Lastly the authors summarize five key points / recommendations. This book is an attractive resource also for universities/ educational seminars/ national and international postgraduate courses and hot-topics sessions at national/international congresses.

1. Introduction -- 2. Paradigmatic shifts in the theory, practice and teaching of medicine in recent decades -- 3. Teaching behavioral and social sciences to medical students -- 4. Difficulties in learning and teaching patient interviewing -- 5. Overcoming difficulties in teaching patient interviewing -- 6. Doctor-patient relations -- 7. Barriers to doctor-patient communication -- 8. Diagnostic utility of the physical examination and ancillary tests -- 9. Physical-examination skills: learning difficulties -- 10. Learning and teaching physical-examination skills by clinical context -- 11. Recording the clinical data base -- 12. Recording personal and social data and examination of asymptomatic persons -- 13. Recording the patient's history -- 14. Intuitive vs analytic clinical reasoning -- 15. Should clinical training rely on role modeling?.

Cardiology -- Endocrinology -- Gastroenterology -- Hematology-Oncology -- Infectious Disease -- Intensive Care -- Nephrology -- Neurology -- Pulmonary -- Rheumatology.

This book discusses how effective navigation requires a team approach to oncology care and should never be considered an "add-on" resource or service. The Academy of Oncology Nurse & Patient Navigators (AONN) is the only national professional organization for navigation professionals, and has more than 6,000 members, 90% of which are oncology nurse navigators. They are the experts on creating team-based programs, which remove the risk of others trying to reinvent the wheel by designing a navigation program from scratch. They also understand the role of effective navigation across the entire continuum of care, and understand and are able to apply other key aspects of navigation, including clinical trial screenings and tumor board coordination and monitoring, as well as measurement using evidence-based navigation metrics, to name but a few.It is the only book designed to educate and support anyone developing a new navigation program, or wanting to improve one they have created.As such it offers a guide for cancer centers needing to develop and implement an oncology navigation program; understand and successfully meet and exceed the Commission on Cancer accreditation standards linked to navigation; expand or improve their current navigation program as well as demonstrate its value using reliable measurable results, including patient satisfaction and improved- quality clinical outcomes. This comprehensive book also provides insights into applying the information presented to the real world of oncology care.

Historical background -- Teamwork in theory -- Teamwork in practice -- Clinical teamwork -- Team communication -- Examples of team rehabilitation settings -- Concluding discussion.

This book is a comprehensive guide to the application of recently introduced and emerging technologies in minimally invasive spine surgery (MISS). These technologies, including 2D and 3D navigation, endoscopy, virtual and augmented reality, robotics, and 3D printing, are helping to overcome previous limitations of MISS, such as the steep learning curve and the need for a great deal of experience in order to achieve optimal outcomes. Compared with traditional techniques, their use is designed to reduce local operative tissue damage, alleviate systemic surgical stress, and enable earlier return to function. The book provides detailed and extensively illustrated accounts of the role of the new technologies and techniques in a wide range of indications. In essence, all spine conditions, whether degenerative, traumatic, or oncologic, will in the near future be amenable to MISS using these approaches. The book will be a source of insight and practical assistance for all surgeons who perform MISS, regardless of their level of experience.

Focal therapy is a promising option for selected patients who have localized low or intermediate-risk prostate cancer, providing a compelling alternative between active surveillance and radical therapies by targeting the index lesion and preserving as much tissue as possible. Numerous cohort studies have already investigated multiple focal techniques, such as cryotherapy, high-intensity focused ultrasound, brachytherapy, photodynamic therapy, laser therapy, irreversible electroporation and cyberknife methods, all of which have demonstrated positive oncological outcomes with 70 to 90 % negative follow-up biopsy. These various ablative techniques have produced only minor side-effects concerning urinary function, a low rate of erectile dysfunction, and have demonstrated a limited rectal toxicity. As a result, the primary end-point has now shifted and a new strategy needs to be established for patient follow-up and for defining treatment failure. Written by international experts in the field, this book is mainly focused on new techniques, all of which are amply illustrated. Technical Aspects of Focal Therapy in Localized Prostate Cancer will be of great practical value to all urologists and oncologists.

The Artisan, the Sage and the Irony: An Outline of Knowledge Sociogenesis -- Technicization of the Neurosciences: Uses of Image-Processing Software in Brain Research -- Cryptography, a Human Science? Models, Matrices, Tools and Frames of Reference -- The Beauty of Equation: The Anthropologist and the Engineer in Design Processes -- Conclusion: Confrontations with Confusions: Stakes to be Re-established.

"In 1990, Dr. Kenneth Krackow wrote The Technique of Total Knee Arthroplasty to teach the basics of TKA for end-stage arthritis--everything from nonsurgical to surgical intervention and postoperative rehabilitation. Now completely revised for a new generation of surgeons, the 2nd Edition of this classic text continues its original goal of helping advanced practitioners acquire more knowledge and skill in primary and revision total knee arthroplasty. This fully updated volume, revised by Dr. Krackow and his former fellows Drs. William M. Mihalko and Michael A. Mont, keeps you current with major changes and advances in field, including patient optimization, outpatient procedures, robotics and new technology, difficult decisions during surgery, and more"-- publisher's description.

"Due to close collaboration between otorhinolaryngologists and neurosurgeons, endoscopic endonasal brain surgery has become part of the surgical armamentarium for successful treatment of various cranial base pathologies. Today, it is considered the gold standard surgical technique for many types of skull base tumors. Techniques and Key Points for Endoscopic Cranial Base Reconstruction by pioneering otorhinolaryngologist Carlos D. Pinheiro-Neto and neurosurgeon Maria Peris-Celda, co-editor of Thieme's acclaimed Rhoton's Atlas of Head, Neck, and Brain, encompasses the most important endoscopic cranial base reconstruction techniques performed in the last two decades. The book features contributions from an impressive group of additional experts in this field."--Provided by publisher.

"Cartilage defects are common. Cartilage repair surgery is not only fascinating but also surgically challenging. There are books dealing with basic science and some surgical aspect. This book fills a gap in surgical techniques for cartilage repair. All of the surgical chapters are logically organised, covering patient selection, patient setup/positioning, surgical approach, potential complications and troubleshooting. An attempt is made to compare with various surgical techniques. This book also covers anaesthesia, postoperative follow-up, pain management and rehabilitation. Both the editors and the authors are renowned experts in the field. This book will be invaluable for orthopaedic and sports medicine surgeons (consultants and training doctors) and is also of potential interest to physiotherapists, medical students, general practitioners, physical medicine and rehabilitation specialists, and rheumatology specialists."--Publisher's website.

This book comprehensively covers minimally invasive laparoscopic and robotic surgical techniques suitable for use in abdominal operations. Chapters describe relevant techniques for abdominal wall reconstruction, esophageal, bariatric, hepatobiliary, and colorectal surgery. Detailed step-by-step procedural guidance is provided with relevant photographic illustrations. Techniques in Minimally Invasive Surgery is a vital resource for surgeons who perform minimally invasive gastrointestinal operations. The book is particularly addressed to trainees, fellows, and junior faculty.

This book provides a guide to the surgical techniques required in thoracic surgery. Minimally invasive surgery (MIS) has become a standard surgical technique in the field of thoracic surgery recently. In addition, the evolution of video equipment and surgical instruments, and robotic devices lead to the rapid development of surgical techniques. Providing the latest and detailed surgical techniques and reviews of video-assisted thoracic surgery and robotic surgery in commonly performed thoracic surgery, and is expected to be of great help to thoracic surgeon who starts minimally invasive surgery.

Chapter 1: Principles of Doppler ultrasound -- Chapter 2: Carotid color duplex scanning -- Chapter 3: Carotid interpretation -- Chapter 4: Vertebral & subclavian artery imaging -- Chapter 5: Venous anatomy and hemodynamics -- Chapter 6: Venous duplex imaging : lower extremities -- Chapter 7: Imaging methods for venous insufficiency -- Chapter 8: Venous imaging of upper extremities -- Chapter 9: Arterial hemodynamics, anatomy, and physiology -- Chapter 10: Physiologic arterial testing : lower extremities -- Chapter 11: Color duplex imaging : lower extremity arteries -- Chapter 12: Arterial bypass grafts & stents -- Chapter 13: Arterial evaluation of the upper extremities -- Chapter 14: Hemodialysis access fistulas & grafts -- Chapter 15: Transcranial Doppler -- Chapter 16: Abdominal Doppler fundamentals -- Chapter 17: Statistics & quality assurance -- Chapter 18: Glossary -- Lab and personal resources -- Chapter-based educational exercises -- CME post-test application information.

Front Cover -- Techniques in Ophthalmic Plastic Surgery -- Copyright Page -- Preface -- Acknowledgments -- Contents -- Video Contents -- 1 The Art of Surgical Technique -- Videos -- Introduction -- Preparation for the Operation -- Firm Plan With Contingencies -- Room Setup -- Equipment Setup -- Skin Marking and Local Anesthesia -- Preparing and Draping The Patient -- Instruments -- Cutting the Skin -- Hand Position -- Scalpel Blades -- Other Cutting Tools -- Placement of Skin Incisions -- Anxiety and Tremor -- Cutting Tissue with Scissors -- How do scissors cut? -- Types Of Scissors Scissors Length -- Scissors Caliber -- Scissors Tips -- Scissors Blade Design -- Scissors Cutting Motion -- Cutting With Scissors (You Learned this as a Child) -- Retraction and Exposure -- Fingers As Retractors -- Skin Hooks -- Forceps -- Dissection Technique -- Retractors -- Hemostasis -- Preoperative Considerations -- Tamponade -- Cautery -- Bipolar Cautery -- Unipolar Cautery -- Bone Wax -- Drugs -- Drains -- Suction -- Suturing -- Types Of Suture Material -- Types Of Needles -- Needle HolDers -- Suturing Technique -- Passing the Needle -- Superficial and Deep Sutures -- Tying the Suture The Surgical Assistant -- Suggested Reading -- 2 Clinical Anatomy -- VIDEO -- Introduction -- Periocular Anatomy -- Skin Creases And Folds -- Eyebrows -- Eyelids -- Orbital Bones -- Orbital Rim -- Bones of the Orbital Rim -- Tripod fracture -- Orbital Walls -- Boundaries of the Walls -- Blowout Fracture -- Bones of the Orbital Walls -- Fissures, Foramina, Grooves, and Canals -- Periorbita -- Muscles That Close the Eyes -- Orbicularis Muscle -- Corrugator And Procerus Muscles -- Underactive Muscles: Facial Nerve Palsy Overactive Muscles: Orbicularis Myokymia, Facial Tics, Essential Blepharospasm, And Hemifacial Spasm -- Canthal Tendons -- Lateral Canthal Tendon -- Slope of the Eyelid -- Lower Eyelid Laxity: The Cause of Ectropion -- Lateral Tarsal Strip Operation -- Lateral Canthal Dystopia -- Medial Canthal Tendon -- Medial Canthal Tendon Laxity -- Telecanthus -- Muscles That Open the Eyes -- Levator Muscle -- Whitnall's Ligament -- Horns of the Levator Aponeurosis -- Müller's Muscle -- Ptosis Of The Upper Eyelid -- Frontalis Muscle -- Lower Eyelid Retractors -- Involutional Entropion -- Horner Syndrome Preaponeurotic Fat and the Orbital Septum -- Preaponeurotic Fat -- Orbital Septum -- Conjunctiva -- Bulbar, Palpebral, And Fornix Conjunctiva -- Diseases Of The Conjunctiva -- Anterior And Posterior Lamellae Of The Eyelid -- Lacrimal System -- Tear Film -- Lacrimal Gland -- Lacrimal Drainage System -- Puncta -- Canaliculi -- Lacrimal Sac -- Nasolacrimal Duct -- Lacrimal Pump -- Nasal Anatomy -- Anatomy of the Paranasal Sinuses -- Ethmoid Sinus -- Frontal Sinus -- Maxillary Sinus -- Sphenoid Sinus -- Innervation to the Periocular Area -- Sensory Innervation

Techniques in Revision Hip and Knee Arthroplasty is the one authoritative volume that gives you an efficient, problem-based approach to revision arthroplasty of both the hip and knee. Dr. Giles Scuderi and other leading experts from North America and Western Europe present their favored surgical procedures and post-surgical management strategies in this straightforward, heavily illustrated, video-intensive reference. It's your one-stop, go-to guide for successful revision surgery for a myriad of complications, such as implant loosening, polyethylene wear, osteolysis, or infection of the hip and knee. Get expert guidance on implant choice, management of complications (including infection and wound healing), and failure of mechanisms, as well as step-by-step surgical techniques.Quickly find the exact information you need with a straightforward "just what you need to know" approach, including surgical tips and pearls.Stay up to date with new insights regarding anatomic landmarks, recommended reconstruction options in revision surgery, including management of bone defects and instability.Access the fully searchable contents of the book and an abundance of surgical videos online at Expert Consult.

1. Wrist arthroscopy portals -- 2. Trapeziometacarpal and scaphotrapezial arthroscopy portals -- 3. Triangular fibrocartilage tears -- 4. Foveal tears and arthroscopy of the distal radioulnar joint -- 5. Ulnocarpal impaction syndrome and ulnar styloid impaction syndrome -- 6. The role of wrist arthroscopy in scapholunate instability -- 7. Lunotriquetral injuries: Arthroscopic management -- 8. Arthroscopic management of dorsal radiocarpal ligament tears -- 9. The role of arthroscopy in midcarpal instability -- 10. Arthroscopic treatment of scaphoid fractures and nonunions -- 11. Arthroscopic treatment of distal radius fractures -- 12. Arthroscopic treatment of intraarticular malunions of the distal radius -- 13. The role of arthroscopy in perilunate injuries -- 14. Arthroscopic wrist capsulotomy -- 15. Arthroscopy in arthritis -- 16. The use of arthroscopy in kienböck disease -- 17. Arthroscopic wrist ganglionectomy -- 18. Arthroscopic radial styloidectomy -- 19. Arthroscopic partial scaphoidectomy for scaphoid nonunion -- 20. Arthroscopic partial wrist fusions --21. Arthroscopic proximal row carpectomy -- 22. Metacarpophalangeal joint arthroscopy -- 23. Arthroscopic treatment of first metacarpal base fractures -- 24. Arthroscopic reduction and percutaneous fixation of fifth carpometacarpal fracture dislocations --25. Arthroscopic treatment of trapeziometacarpal osteoarthritis -- 26. Arthroscopic treatment of scaphotrapeziotrapezoidal osteoarthritis.

PART I. General -- 1. The Economics of Hernia Surgery -- 2. Surgical anatomy of groin and groin hernia -- 3. Abdominal wall hernia classification -- 4. Imaging techniques for abdominal wall hernias -- 5. Future Consideration -- PART II. Groin Hernia -- 6. Biomaterials for Inguinal Hernia Repair -- 7. Anaesthesia for Laparoscopic Abdominal Wall Hernia Repair -- 8. Surgical techniques for Inguinal hernia repair: Open Technique -- Tissue repairs -- 9. Surgical techniques for inguinal hernia repair: open tension-free repairs -- 10. Total extra-peritoneal repair (TEP) -- 11. Trans-abdominal pre-peritoneal repair (TAPP) -- 12. Open and Laparoscopic Repair of Femoral Hernia -- PART IIII. Abdominal Wall Hernia -- 13. Biomaterials For Abdominal Wall Hernia Repair -- 14. Components Separation Technique For Repair Of Complex Abdominal Wall Hernia -- 15. Laparoscopic Incisional And Ventral Hernia Mesh Repair -- 16. Laparoscopic repair of Peripheral Abdominal Wall Hernias -- 17. Laparoscopic Pre-peritoneal Onlay Mesh (PPOM) repair for ventral and incisional hernia -- 18. Muscle- aponeurotic plication associated with dermolipectomy in the treatment of ventral hernias and recti diastasis -- A functional and aesthetic approach -- 19. Minimally invasive subcutaneouscopic and robotic rectus plication -- 20. Parastomal Hernia -- 21. Complications inguinal hernias: Strangulated incarcerated and obstructed hernias -- 22. Sportsman Hernia -- 23. Groin Hernia In The Elderly -- 24. Obesity and Abdominal wall hernias -- 25. Recurrent Inguinal Hernia.

This book provides a complete and thorough guide to the performance of robotic urinary tract reconstruction procedures, including the principals of successful reconstructive techniques in the kidney, ureter, bladder, prostate and urethra. Reviewing patient positioning, trocar placement, instrumentation, detailed steps of procedure, and available outcome data, it outlines both common and advanced techniques, such as revision of uretero-intestinal anastomoses, buccal mucosa graft for long segment ureteral strictures, management of complex fistulas and urethral stricture. Illuminating unusual anatomy, including horseshoe kidney, retrocaval ureter, ureteral duplication, ectopic/malrotated kidneys, and retroperitoneal fibrosis, this book also highlights potential complications, their avoidance and management. Written by experts in the field, Techniques of Robotic Urinary Tract Reconstruction: A Complete Approach guides clinical practitioners in the utilization of advanced novel technology to aid intraoperation and demonstrates the ways in which robotics enables the performance of reconstructive procedures in an area difficult to reach via open techniques.

"Technological Addictions is the first guide designed to provide insight and strategies to clinicians, patients, and families grappling with the collateral damage of technology's pervasiveness and pull. Mental health professionals are beginning to understand that video games, online pornography, internet gaming, internet gambling, and other technological pastimes can be every bit as addictive as substances such as alcohol, tobacco, and illicit drugs. Editor Petros Levounis is among the foremost experts on addiction and, together with coeditor James Sherer and a roster of prominent contributors, has created a groundbreaking book that emphasizes the lived reality of the people who struggle with these addictions every day. In 10 rigorous yet down-to-earth chapters, the book explores the psychological and cultural context of each technology and related behavior, from social media to cybersex, and examines thoroughly the difference between healthy engagement with technology and addiction. This discussion premised on the understanding that technology should not be rolled back or restricted but is an increasingly beneficial and even necessary part of modern life. Two chapters specifically focus on the way technology addictions impact particular populations, such as children and adolescents and older adults. Addiction to technology does not discriminate; no preexisting psychological or physical conditions are required, and everyone is susceptible. Technological Addictions provides guidance found nowhere else, guidance that both clinicians and laypeople will find useful and compelling"-- Provided by publisher.

The book explores how kidney disease care is being changed by new technologies, from inception and diagnosis to dialysis and kidney transplant. Massive technological advances have affected health care in the past decade, and doctors are moving quickly to change the way we provide care for kidney diseases. We are rapidly shifting from hospital- and clinic-based systems to providing care at home, with technologies that help monitor care and intervene remotely. Some of the technologies covered include genetic testing for diagnostic and therapeutic purposes, metabolism/ezposome assessment, AI-driven tool for drug dosing, and apps available to patients. This book aims to educate providers on the many new scientific and technological interventions that can help monitor and mitigate kidney disease.

Ther New Surgeon: Patient-Centered, Disease-Focused, Technology-Driven, and Team-Oriented -- The Ever-Changing Departments of Surgery: The New Paradigm-The Roadmap to a Modern Department of Surgery -- Genomics in Surgery, Trauma, and Critical Care: How Do We Control the Future? -- Nanotechnologies in Surgery: The New Paradigm -- Telemedicine for Trauma and Intensive Care: Changing the Paradigm of Telepresence -- Augmented Reality in Surgery -- The Lean Innovation Model for Academic Medical Discovery -- Changing the Protocol: Is There Still Room for the Professor's Viewpoint? -- Ethical Implications of Advanced Technologies in Surgical Care. Dedicated Resuscitation Operating Room for Trauma -- End Points Resuscitation -- Abdominal Trauma: Not Everything that Bleeds Needs and Operation -- Neurosurgical Advances in Trauma Management -- Damage Control and Organ Injury Priority Management of Trauma Patients -- Multiorgan Dysfuction in Trauma and Surgical Intensive Care Units -- Advances in Burn Care -- Biology of Nutrition Support and Gut Access in Critically Ill Patients -- Advances in Head and Neck Surgery -- Neck Cancer: Imaging Techniques and Progress on the Operative Approach -- Advances in Thyroid and Parathyroid Care -- Neuron Based Surgery: Are We There Yet? Technical Developments in the Surgical Treatment of Brain Injury and Disease -- Brain Cancer: The New Frontiers -- Advanced Thoracoscopic Surgery to Modern Pulmonary Disease: The Japanese Approach -- The Role of Robotics in Selective Throacic Surgical Problems: Technical Considerations -- Cardiac Surgery Advances: Do We Still Remember How to Do Open Bypass? -- Artificial Hearts and Cardiac Assist Devices: The Spectrum of the New Era -- New Valves: Where Do We Stand? -- Technological Advances in Endovascular Surgery -- Carotid Disease: The Stents and the Evidence-Based Medicine-What Happened to the Old Surgery? -- Laporascopic Approaches in General Surgery: Is There Anything New? -- Robotic Applications in Advancing General Surgery -- Natural Orifice Transluminal Endoscopic Surgery (NOTES) -- Bariatric Surgery: The Less, The Better -- New Minimally Invasive Treatments for Acid Reflux -- Minimally Invasive Hepato-Pancreato-Biliary Surgery and Associated GI Interventions -- Pancreatic Advances -- Laparoscopic Liver Resection for Hepatocellular Carcinoma -- Advances in Colorectal Surgery -- Technological Advances in Heart and Lung Transplantation: Concomitant Cardiac Valve Surgery -- Abdominal Organ Transplantation: An Overview -- Small Bowel Transplantation: Is There a Hope on the Horizon? -- Islet Cell Transplantation: New Techniques for an Old Disease -- Face Transplant: The Future is Better Than Current Concepts -- Limp Transplantation -- Advances in Immunosuppressive Therapy -- Tissue Repair and Wound Healing: A Trip Back to the Future -- Surgical Advances in the Treatment of Abdominal Wall Hernias -- Use of Biologic Grafts in Surgery -- Artifical Limbs for Upper Extremity Amputation -- Advanced Technologies in Pediatric Critical Care/Surgery and Fetal Surgery.

Glycemic control -- Home blood glucose monitoring -- Continuous glucose monitoring -- Insulin delivery system -- Closed-loop insulin-delivery system -- Alternatives to insulin injection -- Devices to support treatmtne decisions -- Electronic medical record.

Global climate change is one of the most serious threats to the environment of the earth and to the crop production. Crop vulnerability to climate change stress caused by the greenhouse gases emission is a serious concern. This book describes various technologies and methods including the simulation of the future climate changes, studying the response of crop plants and characterizing their responses physiologically and biochemically. It includes the latest information of protocols and technologies for climate change research on agriculture. This book is of interest to teachers, researchers, climate change scientists, capacity builders and policymakers. Also the book serves as additional reading material for undergraduate and graduate students of agriculture, forestry, ecology, soil science, and environmental sciences. National and international agricultural scientists, policy makers will also find this to be a useful read.

This comprehensive book provides a framework for healthcare providers working with the dual challenges and opportunities presented by the intersection of mental health and technology. Technology and Adolescent Mental Health provides recent, evidence-based approaches that are applicable to clinical practice and adolescent care, with each chapter including a patient case illustrating key components of the chapter contents. Early chapters address the epidemiology of mental health, while the second section of the book deals with how both offline and online worlds affect mental health, presenting both positive and negative outcomes, and focusing on special populations of at-risk adolescents. The third section of the book focuses on technology uses for observation, diagnosis or screening for mental health conditions. The final section highlights promising future approaches to technology, and tools for improving intervention and treatment for mental health concerns and illnesses. This book will be a key resource for pediatricians, family physicians, internal medicine providers, adolescent medicine and psychiatry specialists, psychologists, social workers, as well as any other healthcare providers working with adolescents and mental health care.

This book explores the pivotal role played by technology over the past decade in advancing global public health and health care. At present, the global community faces unprecedented healthcare challenges fueled by an aging population, rising rates of chronic disease, and persistent health disparities. New technologies and advancements have the potential to extend the reach of health professionals while improving quality and efficiency of service delivery and reducing costs within the public and the private health systems. The chapters highlight the barriers faced by the global healthcare workforce in using technology to promote health and human rights of communities: Role of Digital Health, mHealth, and Low-Cost Technologies in Advancing Universal Health Coverage in Emerging Economies Telehealth and Homecare Agencies Technology and the Practice of Health Education in Conflict Zones The Worldwide Digital Divide and Access to Healthcare Technology Technology for Creating Better Professional Teams to Strengthen Healthcare Systems Global Public Health Disaster Management and Technology As a resource on the evolution of technology as a valuable and integral component in the promotion and practice of public health and health care, with a focus on SDG 3 targets, Technology and Global Public Health should engage students, instructors, practitioners, and other professionals interested in public health, universal health care, health technology, digital health, and health equity. Dr. Murthy has been a respected leader and mentor on scientific health-related matters within the UN system for many years. Her book develops a theoretical system connecting concepts that have coined global public health with the rapid development of technology, all with the focus to achieve Sustainable Development Goal number three, within the time frame set by World Leaders. - Henry L. Mac-Donald, Former Permanent Representative of Suriname to the United Nations.

This book provides a complete overview on the latest available technologies in dermatology, while discussing future trends of this ever-growing field. This handy guide provides clinicians and researchers with a clear understanding of the advantages and challenges of laser and imaging technologies in skin medicine today. It also includes a section on imaging techniques for the evaluation of skin tumors, with chapters devoted to dermoscopy, in vivo and ex vivo reflectance confocal microscopy, high frequency ultrasound, optical coherence tomography, and a closing part on latest approaches to wound management. Completed by over 200 clinical images, Current Technology in Practical Dermatology: Non-Invasive Imaging, Lasers and Ulcer Management is both a valuable tool for the inpatient dermatologist and for physicians, residents, and medical students in the field.

1. An introduction to the third dimension for routine cell culture -- Part I. Aggregate-Based Technologies -- 2. Gravity-enforced microtissue engineering -- 3. Physiologically relevant spheroid models for three-dimensional cell culture -- 4. NanoCulture Plate: a scaffold-based high-throughput three-dimensional cell culture system suitable for live imaging and co-culture -- 5. Micro-moulded non-adhesive hydrogels to form multicellular microtissues- the 3D petri dish -- 6. Organotypic microtissues on an air-liquid interface -- Part II. Hydrogels -- 7. Materials and assay systems used for three-dimensional cell culture -- 8. HyStem, a customisable hyaluronan-based hydrogel matrix for 3D cell culture -- 9. 3-D life biomimetric hyrdogels: a modular system for cell environment design -- Part III. Scaffolds -- 10. Alvetex, a highly porous polystyrene scaffold for routine three-dimensional cell culture -- 11. CelluSponge and Go Matrix as innovative three-dimensional cell culture platforms -- 12. Mimetix electrospun scaffold: an easy-to-use tool for 3D cell culture in drug discovery and regenerative medicine -- Part IV. 3D Bioreactor Technologies -- 13. Quasi Vivo bioreactor technology -- 14. Three-dimensional cell-based assays in hollow fibre bioreactors -- 15. Three-dimensional engineered tissues for high-throughput compound screening: mechanical properties of skin and ageing -- 16. Three-dimensional cell culture in the Rotary Cell Culture System -- Glossary -- Index.

"Show me your teeth," the great naturalist Georges Cuvier is credited with saying, "and I will tell you who you are." In this shattering new work, veteran health journalist Mary Otto looks inside America's mouth, revealing unsettling truths about our unequal society. Teeth takes readers on a disturbing journey into America's silent epidemic of oral disease, exposing the hidden connections between tooth decay and stunted job prospects, low educational achievement, decreased social mobility, and the troubling state of our public health. Otto's subjects include the pioneering dentist who made Shirley Temple and Judy Garland's teeth sparkle on the silver screen and helped create the all-American image of "pearly whites"; Deamonte Driver, the young Maryland boy whose tragic death from an abscessed tooth sparked congressional hearings; and a marketing guru who offers advice to dentists on how to push new and expensive treatments and how to keep Medicaid patients at bay. In one of its most disturbing findings, Teeth reveal that toothaches are not an occasional inconvenience, but rather a chronic reality for millions of people, including disproportionate numbers of the elderly and people of color. Many people, Otto reveals, resort to prayer to counteract the uniquely devastating effects of dental pain. Otto also goes back in time to understand the roots of our predicament in the history of dentistry, showing how it became separated from mainstream medicine, despite a century of growing evidence that oral health and general bodily health are closely related. Muckraking and paradigm-shifting, Teeth exposes for the first time the extent and meaning of our oral health crisis. It joins the small shelf of books that change the way we view society and ourselves - and will spark an urgent conversation about why our teeth matter. -- from dust jacket.

1 Introduction -- 2 Overview and Background -- PART I -- Fields of application 3 The community: Early diagnosis and prevention -- 4 The hospital: Improving hospital care for people with cancer -- 5 Home-based care for a better quality of life: Treatment, monitoring and follow-up -- PART II -- Technical Issues 6 New technologies and new frontiers -- 7 The social web -- PART III -- Complex Scenarios and Special Settings -- 8 Rural and extreme rural settings -- 9 Tele-oncology in developing countries -- PART IV -- eLearning 10 Education and distant learning -- 11 Health education to improve prevention -- 12 Conclusions.

A timely, practical, and concise resource for advanced practice registered nursing (APRN) students, faculty, and providers, Telehealth Essentials for Advanced Practice Nursing provides readers with an understanding of and tools to embrace the emerging field of telehealth and optimize its application in clinical practice.

"Offering significant benefits to both healthcare providers and patients, telehealth is a key component in the future of urology and patient care. Telehealth in Urology is a step-by-step, illustrated guide for clinicians who are beginning a telehealth offering or are interested in adopting new digital technologies--all specific and relevant to today's urology practice. It covers the key information you need to know--from necessary equipment to the practice team--with clear explanations of how you can best use telemedicine to provide timely, effective care to every patient"-- publisher's description.

This volume provides a comprehensive, state-of-the art review of inflammatory bowel disease and its management through the use of telemedicine applications. The book reviews barriers to successful outcomes in patients with IBD and offers a rationale for how self-management and telemedicine approaches can improve care in chronic illnesses such as IBD. This volume also includes a summary of the burden of telephone encounters in patients with IBD, characteristics of frequent callers to the office, outcomes associated with high telephone use, and strategies to provide education via telephone to patients with IBD. Prior literature on implementation of teleconsultation in research and clinical practice, as well as mobile applications used to track symptoms, quality of life, diet, and medication use in IBD are also explored in the book. Written by experts in the field, Telemanagement of Inflammatory Bowel Disease is a valuable resource for gastroenterologists, surgeons, and other clinicians dealing with, and interested in, this novel adjunct to routine care for inflammatory bowel disease.

This book provides an overview of key issues with regards to implementing telemedicine services as well as an in depth overview of telemedicine in pulmonary, critical care, and sleep medicine. Topics range from specific practices to program development. Telemedicine has experienced explosive growth in recent years and yet, implementing telemedicine solutions is complex with substantial regulatory, legal, financial, logistical, and intra-organization/intra-personal barriers that must be overcome. This book provides the necessary information and guidance to address those complex issues. This book is broadly divided into two parts 1) a primer on requisite steps before embarking on telemedicine service development and 2) specific applications and examples where telemedicine is successfully utilized to improve quality of care in pulmonary, critical care, and sleep medicine. The first part includes coverage of telemedicine and finance, regulatory and legal issues, and program development. The second part delves into specifics with information on ambulatory telemedicine programs, inpatient consultations, and tele-ICU programs. All chapters are written by interprofessional authors that are leaders in the field of telemedicine with extensive knowledge of diverse telemedicine programs and robust real-world experience on the topic. This is an ideal guide for telehealth program managers, and pulmonary, critical care, and sleep medicine professionals interested in improving their telehealth practice.

This book provides an overview of the innovative concepts, methodologies and frameworks that will increase the feasibility of the existing telemedicine system. With the arrival of advanced technologies, telehealth has become a new subject, requiring a different understanding of IT devices and of their use, to fulfill health needs. Different topics are discussed - from the basics of TeleMedicine, to help readers understand the technology from ground up, to details about the infrastructure and communication technologies to offer deeper insights into the technology. The use of IoT and cloud services along with the use of blockchain technology in TeleMedicine are also discussed. Detailed information about the use of machine learning and computer vision techniques for the proper transmission of medical data - keeping in mind the bandwidth of the network - are provided. The book will be a readily accessible source of information for professionals working in the area of information technology as well as for the all those involved in the healthcare environment.

Telemedicine and telehealth have consistently been shown to be effective for remote areas or limited-resource locations, regular medical and surgical practice, primary care, second opinion, extreme conditions, major crises, and disaster management. The aim of this book is to bring all aspects of telemedicine and e-health to the reader, in a simple, make-sense approach, in one tome. The book is structured in four parts with 29 chapters written by the best experts in the field from around the world, including clinicians, scientists, and administrators of telemedicine programs. Part I deals with basic principles of telemedicine and telepresence. Historical journeys of telemedicine and strategies, building sustainable telemedicine and telehealth programs in the United States and in the Balkans, as well as incorporation of telemedicine in the current ongoing pandemic COVID-19 are well described and are must read. Current technological developments, rules and regulations, legal and business aspects and consent are also addressed. Part II describes strategies for building sustainable telemedicine and telehealth programs. Telehealth patient portals and public-private partnership modes of technology, as well the role of international telemedicine and how to make it work, are valuable chapters of great significance. Part III describes outcomes-based evidence clinical applications of telemedicine in trauma, burns, intensive care, pediatric care, psychiatry, and stroke. Finally, one important chapter for the readers is the telemedicine for prison and jail population. The final part, Part IV depicts surgical telementoring and teleproctoring, a chapter written by 18 various surgical experts, a true gem for the readers. The book ends with promises and hurdles of telemedicine in austere conditions. Telemedicine, Telehealth and Telepresence serves as a valuable resource that focuses on providing patients care from a distance using store and forward technology to live actual performance of operations at a distance.

"This book describes in detail the potential role of ICT and electronic systems, together with the application of Web 2.0 technologies, in telepediatrics and child health. Rather than simply proposing engineering solutions that may soon become outdated, it is designed to address those real needs that telemedicine and developers are asked to meet. The orientation of the book is very much toward primary care, and both low- and high-income settings as well as extreme or complex scenarios are considered. The first two sections of the book describe different fields of application, such as the community, the hospital, and children with chronic illnesses or special needs, and examine technical issues. The use of telemedicine in delivery of care in extreme rural settings and developing countries is then discussed, with attention also to major emergencies and humanitarian crises. The closing chapters consider the role of modern technologies in the education of caregivers who work with children. Child health is a crucial issue in both industrialized and developing countries. Telemedicine for Children's Health will be an excellent guide to the potential value of telemedicine devices in reducing the burden for children and parents and in offering quick and concrete solutions in low-resource scenarios"--Provided by publisher.

As the healthcare landscape evolves towards value-based treatment models, healthcare providers will be forced to find ways to deliver healthcare in a cost-effective, resource mindful way that provides good care, all the while maintaining appropriate patient satisfaction. Telemedicine offers a way to achieve this goal, in both rural and urban settings and with a varied and diverse patient population - not to mention during global health emergencies, where in-person visits and consultations are not ideal. This book will serve as an introduction to telemedicine and digital health for the orthopedic and sports medicine provider. It will provide a general overview of telemedicine as well as specific suggestions and recommendations: where and how to get started, how to implement a telemedicine program, how to do research in telemedicine, and how to develop clinical guidelines and best practices for work in telemedicine. Specific chapters cover important nuts-and-bolts topics like regulation and licensing, billing and coding, and ethics and etiquette. Suggestions and considerations for provider-to-provider, direct-to-consumer, and school-based telemedicine service are likewise presented. Finally, insights into global telemedicine implementation and research are detailed. While describing specific applications to orthopedic and sports medicine practices, Telemedicine in Orthopedic Surgery and Sports Medicine will cater to any clinician - from the individual solo practitioner to the C-suite level executive - who has a vision for implementation of telemedicine across an entire health system.

This text provides a concise, yet comprehensive overview of telemedicine in the ICU. The first part of the book reviews common issues faced by practitioners and hospital administrators in implementing and managing tele-ICU programs, including the merits of different staffing models, the challenges of building homegrown programs versus contracting for services, and the impact of state laws and payer policies on reimbursement for tele-ICU services. The second part of the book presents the current state of evidence for and against ICU telemedicine, based on clinical trials, before-and-after implementation studies, and observational data. The third part dives deeper into specific use cases for telemedicine in the ICU, including telestroke, pediatric and cardiac intensive care, and early treatment of declining patients with sepsis. Written by experts in the field, Telemedicine in the ICU is a practical guide for intensive care physicians and hospital administrators that provides all the information necessary in building and maintaining a successful tele-ICU program.

Mobile Application for Medical Diagnosis -- Emerging Paradigms in Transform-Based Medical Image Compression for Telemedicine Environment -- Adopting m-Health in Clinical Practice: A Boon or a Bane? -- Investigation of Telecardiology System to Detect Cardiac Abnormalities -- Microaneurysms Detection for Early Diagnosis of Diabetic Retinopathy Using Shape and Steerable Gaussian Features -- Telemetry System for Early Detection of Hyperbilirubinemia in Neonates -- WBAN: Driving e-healthcare Beyond Telemedicine to Remote Health Monitoring: Architecture and Protocols -- Remote Monitoring of Children With Chronic Illness Using Wearable Vest -- A Predictive Model for Hypertension Diagnosis Using Machine Learning Techniques -- From Telediagnosis to Teletreatment: The Role of Computational Biology and Bioinformatics in Tele-Based Healthcare -- m-Health in Public Health Practice: A Constellation of Current Evidence -- The Egyptian-African Telemedicine Network: The Treat and Teach Comprehensive Model -- An Extended Views Based Big Data Model Toward Facilitating Electronic Health Record Analytics -- Security and Privacy in Remote Healthcare: Issues, Solutions, and Standards -- Virtual Clinic: A CDSS Assisted Telemedicine Framework.

Introduction to telemental health and its use in resource-limited settings / Hussam Jefee-Bahloul -- Telemental health modalities : videoconferencing, store-and-forward, web-based, and Mhealth / Jessica Becker -- Telemental health in Africa / Sinclair Wynchank and Dora Wynchank -- Telemental health in South Africa / Maurice Mars -- Telemental health in the Middle East / Hussam Jefee-Bahloul and Zakaria Zayour -- Telemental health in India / Rangaswamy Thara, Sujit John, and Kotteswara Rao -- Telemental health services in Sri Lanka / Sisira Edirippulige and Rohana B. Marasinghe -- Telemental health in Taiwan / Hsui-Hsin Tsai -- Telemental health services for indigenous communities in Australia : a work in progress? / Sisira Edirippulige, Matthew Bambling, and Pablo Fernandez -- Refugee telemental health in Denmark / Davor Mucic -- Telemental health delivery for rural Native American populations in the United States / Shawn S. Sidhu, Chris Fore, Jay Shore, and Erin Tansey -- Telemental health in Latin America and the Caribbean / Tammi-Marie Phillip -- Cross-cultural telemental health / Niklas Skov Pape, Rasmus Christian Jørgensen, and Rune Weise Kofoed -- Telemental health in post disaster settings / Eugene F. Augusterfer, Richard F. Mollica, and James Lavelle -- Connecting the world : a way forward in global telemental health / Juan Rodriguez Guzman and Andres Barkil-Oteo.

Part 1. GENERAL -- History of Microsurgery / Yoshikazu Ikuta -- History of Telesurgery / James Wall and Jacques Marescaux -- Description of Robots / Jesse Creed Selber -- Instruments / Sijo Joseph Parekatti and Michael Moran -- Robot Installation in Telemicrosurgery / Thierry Lequint, Kiyohito Naito, Eric Nectoux, Sybille Facca and Philippe Liverneaux -- Part 2. TRAINING -- Earthworms / Gustavo Mantovani Ruggiero -- Vessels / Joo-Yup Lee and Alexander Y. Shin -- Nerves / Stacey H. Berner -- Part 3. EXPERIMENTAL RESEARCH -- Free Tissue Transfer / Stacey H. Berner -- Tele-endomicrosurgery / Sybille Facca, Kiyohito Naito, Thierry Lequint, Eric Nectoux and Philippe Liverneaux -- Brachial Plexus Repair / Gustavo Mantovani Ruggiero and Philippe Liverneaux -- Tendon Transfer / Michael S. Bednar -- Part 4. CLINICAL APPLICATIONS -- Nerve Entrapment / Jose Carlos Garcia Jr. -- Nerve Repair / Stacey H. Berner -- Brachial Plexus / Kiyohito Naito, Mickaël Ohana, Thierry Lequint, Sybille Facca and Philippe Liverneaux -- Skin Flaps / Thomas Lauwers, Tom Van Mulken and Darren Booi -- Muscle Flaps / Jesse Creed Selber and John C. Pedersen -- Head and Neck / Jesse Creed Selber -- Urology / Sijo Joseph Parekattil -- Part 5. PERSPECTIVES -- Supermicrosurgery / Takeshi Todokoro and Isao Koshima -- Network / Catherine Jane Mohr.

Teleneurology in the United States Veteran Health Administration -- International Teleneurology -- Military Telemedicine -- Telemedicine Technology -- Telestroke -- Teleneurointensive Care Unit (TeleneurolICU) -- Teleneurology and Neurointerventional Therapy for Acute Stroke -- Teleneurosurgery -- Hospital Teleneurology -- Telemedicine and Parkinson Disease -- Telebeuropatholgy -- Tele-Epilepsy and Tele-Electroencephalography -- The Emerging Relevance of Telemedicine in Sleep Medicine -- Teledementia -- The Emerging Role of Telemedicine in the Evaluation of Sports-related Concussion -- Teleneurology in Contemporary Graduate Medical Education -- Legal Considerations in the Use of Telemedicine in Neurology -- Reimbursement in Teleneurology.

Applications of Teleophthalmology: Systemic Diseases (Applications) -- Ocular Diseases. Methods used in Teleophthalmology: Novel Imaging Devices -- Information Technologies.

"Performing telephone triage requires the ability to make quick and effective decisions based on limited information. This rapid-access resource delivers more than 200 triage protocols for evaluating patients' symptoms over the telephone. Each symptom entry lists questions, grouped by urgency level, to determine whether the caller should seek emergency care immediately, seek medical care the same day, call back for appointment, or follow home care instructions. Detailed home care instructions are then provided. Simple, direct, and useful, this is the most comprehensive and user-friendly telephone triage book available"--Provided by publisher.

"Triage Protocols for Nurses is a resource to assist health care professionals make quick and effective decisions based on limited information using an algorithmic approach"-- Provided by publisher.

Telerehabilitation, as a subset of telehealth, is the use of telecommunications to deliver rehabilitation services at a distance and can bridge the gaps created by personnel shortages that exist in underserved and remote areas, as well as serve persons in urban settings who cannot easily leave their homes or offices to seek care. Given the mobile nature of our society, telerehabilitation can enable continuity of care while persons travel for work, vacation and/or education. While the technical capacities to conduct telerehabilitation have surged ahead in the past 10 years, there has been slower, yet ongoing progress in the development of the policies (e.g., legislation; state licensure; reimbursement) that will be required to actualize widespread telepractice service delivery. Telerehabilitation presents a wide-angle view of telerehabilitation worldwide at a seminal time in its development. The book contains contributions from authors across multiple disciplines, as well as a consumer-based perspective. This book contributes significantly to the current understanding of telerehabilitation, as well as elucidating the immense potential for telerehabilitation-based service delivery to benefit persons with disabilities.

This book details the practice of telerheumatology. Telemedicine is defined as the delivery of healthcare and the exchange of healthcare information across distances. Following, telerheumatology is the delivery of rheumatology care through telemedicine. There exists an increasing demand from patients, caregivers, and healthcare systems for access to academic specialists through telemedicine. This has been the case for the past several years and the demand has only increased with the ongoing COVID-19 pandemic. There is currently a lack of rheumatologists in rural areas and that is expected to spread to a general lack by 2025. Telerheumatology offers an excellent and timely solution to fill these gaps and provide care Telerheumatology care has been shown to be feasible and quite effective. The current COVID-19 pandemic has thrust the concept of telemedicine into the spotlight. However, not all telerheumatology care is the same and there exists many nuances and differences when examining telerheumatology care across the United States and the world. After comprehensively reviewing the origins of telerheumatology, this work defines in detail the current practice of telerheumatology, along with the specific impact of the COVID-19 pandemic and all applications of telerheumatology. Expert authors also provide a detailed roadmap for providers to initiate, sustain, and grow a telerheumatology program. The book concludes by covering future directions of telerheumatology, including areas for expansion, improvement, and innovation. After reading this work, the editor and all the contributing authors hope that it will inspire, provoke thought and discussion, and lead to increased adaptation of providing telerheumatology care by rheumatologists and rheumatology providers.

The history of telocyte discovery and understanding / Jian Wang, Meiling Jin, Wen-huan Ma, Zhitu Zhu, Xiangdong Wang -- Decoding telocytes / Junjie Xiao, Yihua Bei -- Extracellular microvesicles (EXMVs) in cell to cell communication: a role of telocytes / Mariusz Z. Ratajczak, Daniel Ratajczak, Daniel Pedziwiatr -- Telocytes in chronic inflammatory and fibrotic diseases / Lidia Ibba-Manneschi, Irene Rosa, Mirko Manetti -- Telocytes: new players in gallstone disease / Artur Pasternak, Krzysztof Gil, Andrzej Matyja -- Features of telocytes in agricultural animals / Ping Yang, Nisar Ahmed, Shakeeb Ullah, Qiusheng Chen, Yonghua Zheng -- The telocyte subtypes / Maria-Giuliana Vannucchi, Maria-Simonetta Faussone-Pellegrini -- Telocytes in cardiac tissue architecture and development / Daniele Bani -- The potential role of telocytes for tissue engineering and regenerative medicine / Raymund E. Horch, Annika Weigand, Justus P. Beier, Andreas Arkudas, Anja M. Boos -- Presence of telocytes in a non-innervated organ: the placenta / Cleofina Bosco, Eugenia Díaz -- Telocytes in exocrine glands stroma / Mihnea Ioan Nicolescu -- Telocyte behaviour during inflammation, repair and tumour stroma formation / L. Díaz-Flores, R. Gutiérrez, M. González-Gómez, L. Díaz-Flores Jr, F. Valladares [and others] -- Paracrine signaling in the prostatic stroma: a novel role for the telocytes revealed in rodents' ventral prostate / Bruno D. A. Sanches, Lara S. Corradi, Patricia S. L. Vilamaior, Sebastião R. Taboga -- Primary extragastrointestinal stromal tumours in the hepatobiliary tree and telocytes / Somanath Padhi, Hemanta Kumar Nayak -- Cardiac telocytes in regeneration of myocardium after myocardial infarction / Liao Zhaofu, Cai Dongqing -- Myocardial telocytes: a new player in electric circuitry of the heart / Winston Shim -- Roles of telocytes in the development of angiogenesis / Yonghua Zheng, Xiangdong Wang, -- Telocytes in inflammatory gynaecologic diseases and infertility / Xiao-Jun Yang -- Electrophysiological features of telocytes / Daniel Dumitru Banciu, Adela Banciu, Beatrice Mihaela Radu -- The cutaneous telocytes / Catalin G. Manole, Olga Simionescu, -- The third dimension of telocytes revealed by fib-sem tomography / Dragos Cretoiu -- Immunohistochemistry of telocytes in the uterus and fallopian tubes / Sanda Maria Cretoiu -- A tale of two cells: telocyte and stem cell unique relationship / Zeinab M. El Maadawi -- Vascular telocytes / Hongqi Zhang -- Juxtacerebral tissue regeneration potential: telocytes contribution / Laura Cristina Ceafalan, Bogdan Ovidiu Popescu -- Telocytes of fascial structures / Joanna Dawidowicz, Natalia Matysiak, Sylwia Szotek, Krzysztof Maksymowicz -- Hepatic telocytes / Yingying Zhao, Xiaoyu Chen, Fei Wang, Changqing Yang.

Temporal bone dissection laboratory -- Anatomy of the temporal bone -- Transmastoid approaches -- Translabyrinthine approaches -- Facial nerve decompression -- Middle cranial fossa approaches -- Retrosigmoid retrolabyrinthine approach -- Transotic approach -- Modified transcochlear approach (type A) -- Infratemporal fossa approaches -- Bibliography.

This volume comprehensively reviews the current literature on temporal bone cancer and the multidisciplinary approaches used to managing these rare tumors. The text will review important medical issues as they specifically relate to temporal bone cancer such as advanced imaging, pathologic classification, skull base surgery, plastic reconstructive surgery, and advances in osseointegrated implants for hearing restoration. Additional chapters are dedicated to the evaluation and management, diagnostic radiology, surgical planning and techniques, radiotherapy, chemotherapy, and rehabilitation. An emphasis is placed on the multidisciplinary approach required for the optimal care of these rare tumors. Written by leaders in the field, Temporal Bone Cancer will be an invaluable resource for residents and fellows in Otolaryngology, Neurosurgery and Neurotology, and clinicians with interest in the primary tumors of the temporal bone. .

This book, featuring more than 180 high spatial resolution images obtained with state-of-the-art MDCT and MRI scanners, depicts in superb detail the anatomy of the temporal bone, recognized to be one of the most complex anatomic areas. In order to facilitate identification of individual anatomic structures, the images are presented in the same way in which they emanate from contemporary imaging modalities, namely as consecutive submillimeter sections in standardized slice orientations, with all anatomic landmarks labeled. While various previous publications have addressed the topic of temporal bone anatomy, none has presented complete isotropic submillimeter 3D volume datasets of MDCT or MRI examinations. The Temporal Bone MDCT and MRI Anatomy offers radiologists, head and neck surgeons, neurosurgeons, and anatomists a comprehensive guide to temporal bone sectional anatomy that resembles as closely as possible the way in which it is now routinely reviewed, i.e., on the screens of diagnostic workstations or picture archiving and communication systems (PACS).

Introduction to temporal bone dissection / Howard W. Francis and John Niparko -- Anatomy of the temporal bone / Howard W. Francis and John Niparko -- Mastoidectomy / Howard W. Francis and John Niparko -- Endoscopic middle ear dissection / Alejandro Rivas -- Labyrinthectomy / Howard W. Francis and John Niparko -- Translabyrinthine exposure of the internal auditory canal / Howard W. Francis and John Niparko -- Middle cranial fossa approach to the internal auditory canal / Rick Friedman -- Infratemporal dissection / Rick Friedman -- Skill transfer to the operating room including management of complications / Melville da Cruz -- Promoting competence in temporal bone surgical dissection / Melville da Cruz, Nasir I. Bhatti, John Niparko, and Howard w. Francis.

This book provides a complete overview of imaging of normal and diseased temporal bone. After description of indications for imaging and the cross-sectional imaging anatomy of the area, subsequent chapters address the various diseases and conditions that affect the temporal bone and are likely to be encountered regularly in clinical practice. The classic imaging methods are described and discussed in detail, and individual chapters are included on newer techniques such as functional imaging and diffusion-weighted imaging. There is also a strong focus on postoperative imaging. Throughout, imaging findings are documented with the aid of numerous informative, high-quality illustrations. Temporal Bone Imaging, with its straightforward structure based essentially on topography, will prove of immense value in daily practice.

This book presents standard imaging techniques, basic anatomy and an approach to common pathology encountered in temporal bone imaging. Intended as a survival guide for residents and general radiologists, it covers all topics comprehensively, and provides intuitive point-by-point summaries, similar to those of popular radiology reference sites, for easy comprehension at a glance. The book also offers guidance on the pertinent points that need to be included in a report and how to answer basic questions that are likely to be asked by the referring clinician or supervising radiologist. This book will be a valuable resource for general radiologists, radiology residents, ENT residents, otology surgeons and anyone involved in the occasional temporal bone study.

"A valuable resource on how to diagnose and treat temporomandibular disorders (TMD) The newly and thoroughly revised 2nd Edition of Temporomandibular Disorders: A Problem-Based Approach delivers a systematic and logical approach to diagnosing and treating temporomandibular disorders. Using a case-based approach to assist readers with understanding and retention, the book discusses the practical realities of managing patients and promoting effective treatment of temporomandibular disorders. Containing full colour clinical images and diagrams throughout, the chapters include practical guides on how to make splints and samples of patient information sheets which can be used as templates. Readers will get access to topics such as: The clinical aspects of anatomy, function, pathology, and classification; Differential diagnosis of temporomandibular joint problems; Clicking joint problems and the use of preliminary investigation in disc displacement; Temporomandibular joint locking diagnosis and treatment, including final treatment plans; Facial pain examinations, differential diagnosis, and questions to ask patients regarding pain in general; Headaches, worn teeth, dislocated jaws, and more issues that arise in the treatment of temporomandibular joint problems"-- Provided by publisher.

This book on the local and systemic manifestations and correlates of temporomandibular joint disorders (TMDs) encompasses the two intertwined facets of translational science -- translational research and translational effectiveness -- as they relate specifically to TMDs. The first part of the book, on recent translational research, focuses on topics such as the neuroanatomy and neurophysiology of the trigeminal nerve and trigeminal network system, the manifestations of neuroinflammation in TMDs, and the molecular mechanisms underlying TMDs. The second part discusses the clinical effectiveness of treatment approaches from the perspective of evidence-based dentistry, with careful attention to the critical relationships between dental malocclusions, the signs and symptoms of TMDs, and airway/breathing disorders. Interventions to correct for malocclusal conditions that lead to TMDs are examined, with explanation of the ways in which they can ameliorate a variety of local and systemic symptoms. This will be an excellent reference book for established practitioners, residents, interns, and students as well as a powerful cutting-edge document for researchers in the field. .

This book is designed to provide a crisp and necessary information for all the under-graduate and post-graduate medical students, Oral and Maxillofacial Surgeons, ENT Surgeons, General Surgeons, General Dentists and other health care workers who deal with TMDs in their practise. It includes contributions from eminent surgeons across the world who treat TMJ disorders and diseases using various conventional to modern state of the art techniques. Temporomandibular joint disorders (TMDs) are familiar yet difficult to diagnose in routine practice due to the complexity of the joint and its surrounding structures. The symptoms usually associated with TMDs present with pain, joint sounds such as click or crepitus, difficulty during mastication, reduced mouth opening are some of the many presentations. Definite diagnosis of the TMDs can be challenging as the patients present with varying symptoms. These disorders of the joint can vary from a simple disc displacement to complex pathologies. Management of the TMDs can be tricky and hence need a thorough evaluation of the joint and surrounding structures. There has been a tremendous leap in managing these disorders from simple conservative management to several advanced surgeries to salvage the joint. This compilation highlights all the relevant details regarding TMDs and its management which will offer utmost details to practising surgeons who often deal with TMDs. This book will be a delight to read for all the clinicians and surgeons who are interested in treating the small yet complex jaw joint in the facial region.

Part I Introduction -- Introduction -- TMJ Biomechanics -- TMJ TJR Biomaterials Considerations -- History of TMJ TJR (Mercuri) -- Part II TMJ TJR Devices -- Stock TMJ TJR Devices -- Custom TMJ TJR Devices -- Part III Advanced TMJ TJR Techniques -- TMJ TJR in combination with orthognathic procedures -- Mandibular replacement utilizing TMJ TJR devices -- Part IV Complications -- TMJ TJR surgical Complications, prevention and management -- Material Hypersensitivity -- Tribocorrosion and TMJ TJR devices -- Management of failing and failed TMJ TJR Devices -- Part V Future Considerations -- Bioengineered Tissue TMJ TJR.

Structure of the oral tissues -- General embryology -- Embryology of the head, face, and oral cavity -- Cytoskeleton, cell junctions, fibroblasts, and extracellular matrix -- Development of the tooth and its supporting tissues -- Bone -- Enamel : composition, formation, and structure -- Dentin-pulp complex -- Periodontium -- Physiologic tooth movement : eruption and shedding -- Salivary glands -- Oral mucosa -- Temporomandibular joint -- Facial growth and development -- Repair and regeneration of oral tissues.

"Understand oral histology and learn to apply your knowledge in the clinical setting with this definitive reference. Now in full color and thoroughly updated, this 8th Edition provides insight on contemporary research and trends in oral histology, embryology, physiology, oral biology, postnatal growth and development that is essential to your success in oral health!"--Provided by publisher.

Introduction: The GW Body Story as an Example of Autoantibodies with Significant Impacts to Molecular Cell Biology -- The Discovery of GW Bodies -- The Discovery and Analysis of P Bodies -- Autoantibodies to Argonaute 2 (Su Antigen) -- GW/P-Bodies and Autoimmune Disease -- Function of GW182 and GW Bodies in siRNA and miRNA Pathways -- Post-transcriptional Stimulation of Gene Expression by MicroRNAs -- Gawky (GW) is the Drosophila melanogaster GW182 Homologue -- The Role of GW182 Proteins in miRNA-Mediated Gene Silencing -- Quantifying Argonaute Proteins In and Out of GW/P-Bodies: Implications in microRNA Activities -- Deadenylation and P-Bodies -- Relationship of GW/P-Bodies with Stress Granules -- Relationship of Other Cytoplasmic Ribonucleoprotein Bodies (cRNPB) to GW/P Bodies -- An SNP in the Trinucleotide Repeat Region of the TNRC6A Gene Maps to a Major TNGW1 Autoepitope in Patients with Autoantibodies to GW182 -- Reflections on Ten Years of History of, and Future Prospects for, GW182 and GW/P Body Research.

This comprehensive office guide will provide up-to-date diagnostic and management information for various tendinopathies seen in the clinic. Opening chapters discuss the basic science of tendons: physiology, pathophysiology and biomechanics, including mechano-transduction. Subsequent chapters focus anatomically on both the upper and lower extremities, from the rotator cuff to the wrist and hand, and from the groin and gluteus down to the foot and ankle. Each of these chapters follows a concise, easy-to-use format, consisting of an introduction followed by clinical presentation, physical examination, imaging and radiographic grading, and treatment strategies both surgical and non-surgical, including indications for surgical referral. The concluding chapters present emerging mechanical, orthobiologic and chemical in-office procedures as well as emerging operative techniques. Practical and user-friendly, Tendinopathy will be an excellent resource for sports medicine specialists, orthopedic surgeons, physical therapy and rehabilitation specialists, and any other clinicians treating these common athletic injuries.

Injuries of the foot and ankle can be debilitating and lead to chronic instabilities that can impede the daily activities of patients. As a result, it requires a solid understanding of foot and ankle anatomy and pathology in order to diagnosis these types of injuries and establish a clear treatment regimen for the patient to be functional and prevent long-term complications. For the foot and ankle specialist, the understanding of the injury patterns and treatment algorithms continues to evolve with the addition of new information on non-surgical and surgical techniques that are continuing to be introduced to the medical community. However, it is important to determine how the latest developments and treatment advances are disseminated through an evidence-based approach, to allow for proper evaluation of their usefulness as well as how to properly initiate and perform these treatments during patient care. To that end, this book provides a comprehensive overview of the diagnosis and management of muscle, tendon and ligament injuries of the foot and ankle. Opening with a review of diagnostic and imaging procedures, focused, concise chapters then describe the current evaluation and management strategies for a wide variety of soft tissue conditions, including turf toe, Lisfranc injuries, acute and chronic later ankle injuries, subtalar joint injuries, peroneal tendon injuries, and Achilles tendon injuries, among others. Each chapter brings together and reviews the latest literature on the topic, offering evidence-based guidelines for foot and ankle specialists, orthopedic surgeons and podiatrists as well as residents, fellows and all staff involved in the treatment of these injuries and conditions.

Section I: Etiology -- Definition, Causes and Epidemiology -- Tennis Elbow in Athletes: More Than Just Tennis? -- Golfer's Elbow: Treatment Distinctions -- Section II: Conservative Treatment -- Evidence for No Treatment and Self-limited Treatment -- Medical Management: The Role of NSAIDS and Topical -- Therapy -- Splints -- Steroid Injections -- Blood and PRP Injections -- Other Treatments: Prolotherapy, Acupuncture, ESWL -- Section III: Surgery -- Open Surgical Treatment -- Arthroscopic Treatment -- Denervation -- Percutaneous Release -- Outcomes of Treatment and Return to Play: The Evidence -- Complications of Surgical Treatment and Salvage Procedures for Failed Surgery.

This book will serve as a key resource for all clinicians working in orthopedics, sports medicine, and rehabilitation for the sport of tennis. It provides clinically useful information on evaluation and treatment of the tennis player, covering the entire body and both general medical and orthopedic musculoskeletal topics. Individual sections focus on tennis-related injuries to the shoulder, the elbow, wrist, and hand, the lower extremities, and the core/spine, explaining treatment and rehabilitation approaches in detail. Furthermore, sufficient sport science information is presented to provide the clinical reader with extensive knowledge of tennis biomechanics and the physiological aspects of training and rehabilitation. Medical issues in tennis players, such as nutrition and hydration, are also discussed, and a closing section focuses on other key topics, including movement dysfunction, periodization, core training, and strength and conditioning specifics. The expansive list of worldwide contributors and experts coupled with the comprehensive and far-reaching chapter provision make this the highest-level tennis medicine book ever published.

ICH S5(R2) guideline for the testing of medicinal agents / L. David Wise -- Nonclinical reproductive toxicity testing requirements for drugs, pesticides, and industrial chemicals in India and China / K.S. Rao and Jing Dong -- Developmental toxicity testing of biologics / Keith P. Hazelden -- OECD guidelines for the testing of chemicals and pesticides / Jochen Buschmann -- Teratology testing under REACH / Steve Barton -- Teratology testing of food additives / Paul C. Barrow and Francois Spezia -- Developmental toxicity testing of vaccines / Paul C. Barrow and Linda Allais -- Teratology testing of cosmetics / Francois Spézia and Paul C. Barrow -- Teratology studies in the rat / Mariline Leroy and Linda Allais -- Teratology studies in the mouse / Edward Marsden and Mariline Leroy -- Combined fertility and embryotoxicity study / Lucie Reynaud and Edward Marsden -- Teratology studies in the rabbit / Linda Allais and Lucie Reynaud -- Teratology studies in the minipig / Peter A. McAnulty -- Embryo fetal development studies in nonhuman primates / Antje Fuchs, Eberhard Buse, and Gerhard F. Weinbauer -- Enhanced pre- and postnatal development study for monoclonal antibodies / Gerhard F. Weinbauer, Joerg Luft, and Antje Fuchs -- Skeletal examination by alizarin staining / Lucie Reynaud and Audrey Jocteur-Monrozier -- Skeletal examination by double staining for ossified bone and cartilaginous tissue / Steffen Schneider -- Small animal imaging and examination by micro-CT / Sergio X. Vasquez, Neha Shah, and Alan M. Hoberman -- Fetal soft tissue examination by serial sectioning / Karon Critchell -- Fetal soft tissue examinations by microdissection / Mariline Leroy and Audrey Jocteur-Monrozier -- Soft tissue examination of the fetal rat and rabbit head by magnetic resonance imaging / Julian M. French and Neil Woodhouse -- Historical control data in reproductive and developmental toxicity studies / Eve Mylchreest and Stephen B. Harris -- Reporting of teratology studies / Paul C. Barrow and Lucie Reynaud -- Maternal toxicity / Bengt R. Danielsson -- Innovations in testing strategies in reproductive toxicology / Aldert H. Piersma -- Predictive models and computational toxicology / Thomas Knudsen, Matthew Martin, Kelly Chandler, Nicole Kleinstreuer, Richard Judson, and Nisha Sipes -- Embryonic stem cell test / Sjors H.W. Schulpen and Aldert H. Piersma -- Zebrafish teratogenicity testing / Kimberly C. Brannen, Jeffrey H. Charlap, and Elise M. Lewis -- Frog embryo teratogenesis assay on Xenopus and predictivity compared with in vivo mammalian studies / Isabelle Leconte and Isabelle Mouche -- Rat whole embryo culture assay using the dysmorphology score system / Cindy Zhang, Julie Panzica-Kelly, and Karen Augustine-Rauch -- Toxicogenomic approaches in developmental toxicology testing / Joshua F. Robinson and Aldert H. Piersma -- Validation of alternative tests for developmental and reproductive toxicology testing : an ILSI Health and Environmental Sciences Institute perspective / James H. Kim -- Regulatory assessment of reproductive toxicology data / Elizabeth Davidson -- Hazard and risk assessment of teratogenic chemicals under REACH / Wiebke Prutner -- Reproductive toxicity risk assessment for pesticides / Beate Ulbrich -- Thalidomide disaster, lessons from the past / James E. Ridings.

This set of teaching notes provides extensive guidance for educators related to its sister title and contains numerous tools and questions to help educators provide didactics and evaluation of students in this essential area of biomedical informatics. This is needed to understand the central topics of ontology, terminology and terminological systems in healthcare. Twenty-five years ago the notion that ontology would be essential to knowledge representation in healthcare was all but unknown. Almost all important terminologies and many ontologies are now in wide use and are growing in importance. With no general model of what a ontology and terminology should be, there are an increasing number of tools to support ontology / terminology development, implementation and maintenance. Steady progress since then has improved both ontology / terminology content and the technology and processes used to sustain that content. Terminology, Ontology and their Implementations: Teaching Guide and Notes provides extensive teaching materials to accompany Terminology, Ontology and their Implementations . It provides further definition of the topic and explains the use of reference terminologies needed to use them safely. It contains questions and explanations from each section of the textbook, making it easier to use the text in teaching Health Informatics students. The authors also provide supplementary information about the questions, their relevance and their relation to other concepts. This book augments Terminology, Ontology and their Implementations by assisting the understanding of terminology services and the architecture for terminological servers, and consequently serves as an essential tool for educators in their efforts to teach students in their study of health informatics.

"From injuries caused by lead poisoning to the devastating effects of atmospheric pollution, infectious disease, and industrial waste, Americans of color are harmed by environmental hazards in staggeringly disproportionate numbers. This systemic onslaught of toxic exposure and institutional negligence causes irreparable physical harm to millions of people across the country--cutting lives tragically short and needlessly burdening our health care system. But these deadly environments create another insidious and often overlooked consequence: robbing communities of color, and America as a whole, of intellectual power. The 1994 publication of The Bell Curve and its controversial thesis catapulted the topic of genetic racial differences in IQ to the forefront of a renewed and heated debate. Now, in A Terrible Thing to Waste, award-winning science writer Harriet A. Washington adds her incisive analysis to the fray, arguing that IQ is a biased and flawed metric, but that it is useful for tracking cognitive damage. She takes apart the spurious notion of intelligence as an inherited trait, using copious data that instead point to a different cause of the reported African American-white IQ gap: environmental racism--a confluence of racism and other institutional factors that relegate marginalized communities to living and working near sites of toxic waste, pollution, and insufficient sanitation services. She investigates heavy metals, neurotoxins, deficient prenatal care, bad nutrition, and even pathogens as chief agents influencing intelligence to explain why communities of color are disproportionately affected--and what can be done to remedy this devastating problem"--Dust jacket.

"This text should serve to highlight test taking weaknesses and the skills or strategies that may be useful to improve those weaknesses. Such weaknesses include a poor approach to the exam, difficulty reasoning through concepts, difficulty categorizing information, and anchoring. These weaknesses are the focus of this text. There are also skills and strategies that are important to refine as we become expert test-takers, such as time management, approach to reviewing labs, dealing with under confidence, and re-viewing answer choices at the end of an exam. You will be lead through general and specific test taking skills and weaknesses with practice questions so that upon completion of this text, you will hopefully be fully equipped to achieve the score (and career) of your dreams"--Publisher's description.

1. Biological background of testicular autoimmunity -- 2. Microcircumstance for induction and prevention of testicular autoimmunity -- 3. Human testicular autoimmunity as a result of breakdown of testicular immune privilege -- 4. Testicular autoimmunity by immunization with testicular antigens alone in experimental animals -- 5. Testicular autoimmunity by the systemic treatment with immuno-potentiating agents in experimental animals -- 6. Testicular autoimmunity by local injury of the testis in experimental animals -- 7. Testicular autoimmunity by alteration of the immune system in experimental animals -- 8. The future directions of testicular autoimmunity investigation -- Erratum.

This volume provides a brief resume of the history of testosterone research, from the early pioneers through to the most recent advances in the field. We discover how steroid hormones were first identified and how testosterone was shown to be essential for male development. Moving forward we explore how and where testosterone is produced, and how the body controls testosterone production. We then investigate the impact testosterone has on different body systems both during their development and function, and how perturbation of testosterone action is associated with disease. We complete our story with an exploration of the emerging roles of testosterone in clinical therapy, and the future potential for manipulation of the testosterone signaling system for human health benefit.

Tetraspanin proteins have recently emerged as a new class of modulators of various processes involving cell surface receptors, including cell migration and invasion, host immune responses, cell-cell fusion, and viral infection. The book summarises recent advances in the fields of biology in which the role of tetraspanins have been established and also covers the molecular evolution of the tetraspanin superfamily and structural aspects of the organisation of tetraspanin microdomains.

"Wound care is covered in the 2nd or 3rd year of Physical Therapy school and is a part of every school's curriculum. Examples of interventions that are provided by physical therapists inlcude sharp debridement, dressing selection and application, compression for both chronic venous insufficiency and lymphedema, electrical stimulation, total contact casets and orthotic fabrication for neuropathic wounds, ultrosound, pulsed lavage with suction and negative pressure wound therapy. In addition, many worund therapists are included in the diagnostic provecess, especially determining the functional and gait impairments that may contribute to wound formation"-- Provided by publisher.

This book combines clear explanatory text with a wealth of images of ECG recordings in order to provide an accessible, up-to-date source of information and guide to interpretation for all professionals seeking to increase their expertise in electrocardiography. ECG results are presented and discussed for a wide range of conditions, including all forms of arrhythmia, Wolff-Parkinson-White syndrome, bundle branch blocks, ischemic cardiomyopathy, atrial and ventricular enlargement, pericardial and myocardial diseases, diseases of the pulmonary circulation, and post pacemaker implantation. Normal ECG findings are fully described, and helpful introductory information is included on the principles of electrophysiology. The practically oriented text accompanying the ECG recordings covers both electrophysiological and clinical aspects. More than 100 years after its first use by Willem Einthoven, electrocardiography continues to be the first diagnostic tool applied in most cardiac patients. This text atlas provides a sound basis for the correct ECG interpretation essential for appropriate patient management.

v. 1. Head and neck -- v. 2. Chest -- v. 3. Abdomen -- v. 4. Bones, joints and soft tissues.

A reliable, cost-effective approach to extracting priceless business information from all sources of text Excavating actionable business insights from data is a complex undertaking, and that complexity is magnified by an order of magnitude when the focus is on documents and other text information. This book takes a practical, hands-on approach to teaching you a reliable, cost-effective approach to mining the vast, untold riches buried within all forms of text using R. Author Ted Kwartler clearly describes all of the tools needed to perform text mining and shows you how to use them to identify practical business applications to get your creative text mining efforts started right away. With the help of numerous real-world examples and case studies from industries ranging from healthcare to entertainment to telecommunications, he demonstrates how to execute an array of text mining processes and functions, including sentiment scoring, topic modelling, predictive modelling, extracting clickbait from headlines, and more. You'll learn how to: -Identify actionable social media posts to improve customer service -Use text mining in HR to identify candidate perceptions of an organisation, match job descriptions with resumes, and more -Extract priceless information from virtually all digital and print sources, including the news media, social media sites, PDFs, and even JPEG and GIF image files -Make text mining an integral component of marketing in order to identify brand evangelists, impact customer propensity modelling, and much more Most companies' data mining efforts focus almost exclusively on numerical and categorical data, while text remains a largely untapped resource. Especially in a global marketplace where being first to identify and respond to customer needs and expectations imparts an unbeatable competitive advantage, text represents a source of immense potential value. Unfortunately, there is no reliable, cost-effective technology for extracting analytical insights from the huge and ever-growing volume of text available online and other digital sources, as well as from paper documents-until now.

v. 1. Principles and methods. Cornea and anterior chamber -- v. 2. Lens and zonule -- v.3. Iris, vitreous body, conjunctiva.

This textbook is the new edition of Purnell's famous Transcultural Health Care, based on the Purnell twelve-step model and theory of cultural competence. This textbook, an extended version of the recently published Handbook, focuses on specific populations and provides the most recent research and evidence in the field. This new updated edition discusses individual competences and evidence-based practices as well as international standards, organizational cultural competence, and perspectives on health care in a global context. The individual chapters present selected populations, offering a balance of collectivistic and individualistic cultures. Featuring a uniquely comprehensive assessment guide, it is the only book that provides a complete profile of a population group across clinical practice settings. Further, it includes a personal understanding of the traditions and customs of society, offering all health professionals a unique perspective on the implications for patient care.

This book provides a systemic approach to acute trauma care in line with the ABCDE paradigm and up-to-date information on assessing and managing major trauma from the pre-hospital to the rehabilitation phase. The book's early sections are dedicated to identifying and managing pathology caused by massive haemorrhage, airway, breathing, circulation or neurological trauma and examining the current evidence base relating to their management. The book then builds from fundamental skills to advanced interventions so that each level of responder can identify and implement aspects of clinical practice that will be of benefit to them at their stage. This approach also explains advanced interventions that may be executed subsequently, explaining how each phase of care sits together. This has a further benefit of producing seamless care for patients by practitioners of different levels using this book as a reference point. Later sections deal with specifics of in-hospital trauma care by specialty, including the explanation of decision making processes by specialties, use of diagnostic and interventional radiology, rehabilitation and psychological aspects of trauma care. The Textbook of Acute Trauma Care also focuses on non-clinical issues relevant to trauma such as training and logistics of retrieval and repatriation, aviation considerations in HEMS, legal and forensic evidence considerations and ethical issues dealing with trauma patients. In addition, the book contains chapters from international experts on cognitive and human factors relating to healthcare and suggests strategies for training and minimising errors. This book is an essential resource for all grades of practitioner, from first responders to Consultant/Attending Physician level providers.

Addiction is increasingly being recognized as a major global public health issue, and an ever-growing number of medical specialties, psychological and social science training programs, and professional associations are including addiction as part of their training and continuing education curricula. The first edition of this book presented an overview of the spectrum of addiction-related problems across different cultures around the globe. Sharing the experience and wisdom of more than 260 leading experts in the field, and promoted by the International Society of Addiction Medicine, it compared and contrasted clinical practices in the field of addiction medicine on the basis of neurobiological similarities as well as epidemiological and socio-cultural differences. Building on the success of this inaugural edition, and taking into account the formal and informal comments received as well as an assessment of current need, this textbook presents general updated information while retaining the most requested sections of the first edition as demonstrated by the number of chapter downloads. It also provides a basic text for those preparing for the ISAM annual certification exam. Written by some 220 international experts, it is a valuable reference resource for anyone interested in medicine, psychology, nursing, and social science.

This primary text encompasses the full scope of AGNP primary care practice across multiple healthcare settings including telehealth. The text emphasizes the best available evidence to promote person-centered care, quality improvement of care, interprofessional collaboration, and reducing healthcare costs. The text delivers timely information about current healthcare initiatives in the U.S., including care coordination across the healthcare continuum, interprofessional collaboration, and accountable care organizations. Disease-focused chapters contain general and specific population-based assessment and interprofessional care strategies to both common and complex health issues. They offer consistent content on emergencies, relevant social determinants of health, and ethical dilemmas. The text also prepares students for the administrative aspects of practice with information on the physical exam, medications, billing, coding, and documentation. Concise, accessible information is supported by numerous illustrations, learning objectives, quality and safety alerts, clinical pearls, and case studies demonstrating best practice. A robust ancillary package includes an Instructor's Manual with case studies and teaching guides, a Test Bank reflective of clinical situations and patient conditions, PowerPoints covering key concepts, and an Image Bank of skin conditions and other figures. -- Provided by publisher.

Part I. Basic sciences/physiology/histology -- Part II. Molecular biology and metabolism -- Part III. Endogenous and exogenous factors -- Part IV. Disease state/conditions with aging -- Part V. Techniques, methods, and tools -- Part VI. Toxicology/safety and microbiology -- Part VII. Genomics -- Part VIII. Skin scales and typing system -- Part IX. Skin health, nutrition, resilience, rejuvenation, and management of aging skin -- Part X. Psychosocial implications -- Part XI. Aging perception -- Part XII. Gender, ethnicity, and lifestyle differences -- Part XIII. Sensitive skin and aging -- Part XIV. Ingredients, products, and cosmetics for aging skin beauty -- Part XV. Cosmetic surgeries -- Part XVI. Mind/skin/body interaction -- Part XVII. Global market place, social and emotional aspects for the aged -- Index.

Allergies are a significant health issue, yet few books exist on allergen tolerance of separation; here the author classifies allergen tolerance breakdown in specific types, according to the possibility that the autonomic breakdown of allergen tolerance in the unified airway depends on a deficit of pro-tolerogenic neurotransmitters at the local level. This paradigm, which explains the pathogenesis of allergic disorders, opens to new approaches to allergen-specific immunotherapy (AIT). While focusing on the new atopic disorders of the unified airway, such as local allergic rhinitis, "dual" allergic rhinitis, local allergic asthma, and local allergic conjunctivitis, the work combines clinical examples of allergic diseases and their treatment with their immunological background. The topics range from the specific immune-derived maintenance of allergen tolerance and the role of the neuroimmune network in allergic inflammation to conventional atopic diseases and more particular issues of local atopic disorders in the unified airway, oral tolerance, and its breakdown, and its translation in genitourinary aspects of allergic inflammation. Specific chapters are also devoted to allergen-specific immunotherapy (AIT) and anti-allergy treatments. Thought for upper graduate students, it will also be a valued resource for allergy practitioners, pulmonologists, ENT specialists, pediatricians, and translational researchers, Textbook of Allergen Tolerance includes classical didactic features such as abstracts, keywords, background notes, discussion points, and Q&A., as well as 20 audio files Text-to-Speech for the visually impaired, and 10 video to support the readers. .

The most current, comprehensive work available to date, the Textbook of Antisocial Personality Disorder is the definitive source of information on this difficult and often poorly understood and underdiagnosed disorder. A group of distinguished international experts, researchers, and clinicians provide their unique perspectives on what has been learned so far about antisocial personality disorder (ASPD) and other forms of antisocial behavior, including childhood conduct disorder, adult antisocial behavior, and psychopathy. Highly useful for both clinicians tasked with caring for these patients and researchers involved in probing its causes and treatments, the book looks at the phenomenology and natural course of ASPD, as well as its neuropathology, neurophysiology, genetic risk factors, epigenetics, and social determinants. The authors also explore some promising directions regarding prevention and treatment. Throughout the book, illustrative case vignettes provide a real-world view of people diagnosed with ASPD, including symptoms, course, and severity. In addition, tables, graphs, and illustrations further define the important points. Urgently needed and written with authority by those at the forefront of this vexing disorder, the Textbook of Antisocial Personality Disorder provides useful information on topics such as • The history and definition of ASPD• Clinical concepts such as epidemiology, comorbidity, symptoms, and course• Suspected causes of the disorder• Neurophysiology, neurotransmitters, and neuroimaging of the disease• The relationship of ASPD to psychopathy• Current treatment recommendations Special coverage is included on antisocial women, antisocial children, antisocial sexual offenders, forensic aspects of ASPD, and preventive strategies.-- Provided by publisher.

Groundbreaking, comprehensive, and developed by a panel of leading international experts in the field, Textbook of Assisted Reproduction provides a multidisciplinary overview of the diagnosis and management of infertility, which affects 15% of all couples around the world. The book aims to cover all aspects of assisted reproduction. Particular attention is given to topics such as the assessment of infertile couples; assisted reproductive techniques (ARTs) including ovulation induction, intra uterine insemination (IUI), in vitro fertilization (IVF) and intracytoplasmic sperm injection (clinical and laboratory aspects); reproductive genetics; and obstetric and perinatal outcomes.

"More than 40 years after the official recognition of infantile autism in DSM-III, advances continue to be made in our understanding of the possible causes, assessment and evaluation, and treatment of autism spectrum disorder (ASD). With contributions by dozens of experts in the field, this second edition of the Textbook of Autism Spectrum Disorders has been updated to reflect the latest research in ASD. Unrivaled in its thoroughness, this volume discusses issues of assessment and evaluation; examines the etiology of ASD and its recognized associations with other medical conditions; analyzes standard and experimental treatments; and delves into social policy issues pertinent to individuals with ASD and those who treat them. With summary points in each chapter and copious lists of recommended readings, this is an indispensable resource for psychiatrists, psychologists, neurologists, social workers, speech therapists, educators, and all others in the continuum of care"-- Provided by publisher.

This book, the first complete textbook on this novel field in Medicine, comprehensively covers the clinical presentation, pathogenesis, genetics, and latest management strategies for autoinflammatory disorders as well as the basic science of autoinflammation. Relevant concepts such as how translational science of genetics and immunology relates to the innate immune system and autoinflammation are covered. Descriptions of the monogenic and polygenic/complex diseases that fall under the umbrella of autoinflammatory diseases are provided. Further topics covered include the latest clinical and genetic diagnostic approaches, concepts on the relationship between autoinflammation and autoimmunity/immunodeficiency, the role of autoinflammation in cancer, treatments and management strategies for these diseases, and potential areas of future development. The Textbook of Autoinflammation systematically describes and reviews diagnostic and treatment options for autoinflammatory disorders as well as all aspects of the concept of autoinflammation, and represents a valuable resource for professionals in a variety of disciplines who encounter these patients or who study autoinflammation.

An informative and practical guide to the most common major operation in the world. Written by a distinguished team of contributors, it describes best practice for procedures, as well as important related issues.

This textbook provides a practical and board-driven resource to describe and define the emerging field of cardiorenal medicine. Covering all aspects of the topic with depth and relevance, this groundbreaking reference brings together experts at the nexus between cardiovascular and renal medicine to provide an exception reference to educate in this critical area of modern medicine. It describes how the heart and kidneys are inextricably linked via hemodynamic, neural, hormonal and cellular signaling systems and, concentrating on disease-based coverage, goes on to review emerging concepts in epidemiology, pathogenesis, screening, diagnosis and the management of cardiorenal syndromes, all extensively illustrated and containing features to support scholarship in the field. Textbook of Cardiorenal Medicine provides consistent chapter organization, clear design and engaging text to define the diagnosis, treatment, intervention and surgical aspects of the full range of conditions encountered within this area of medicine. It is therefore an essential resource to all involved in the management of cardiorenal disease.

Catheter-based interventions have evolved to address a variety of needs through innovation and clinical evidence.The field of interventional cardiology and interventional vascular medicine now comprises the dominant diagnostic and therapeutic field within cardiovascular medicine, and continues to grow in terms of patients managed and physicians trained. Given the vast expansion of technologies, techniques, and the clinical evidence base, it can be challenging for the practicing clinician, fellow-in-training, or technology developer to maintain general knowledge of the interventional cardiovascular field.The Textbook of Cardiovascular Intervention is intended to provide a practical, comprehensive and compact text on interventional cardiology for the current, rapidly evolving practice environment. It will appeal to fellows, residents and physicians in cardiology, interventional cardiology, cardiothoracic and vascular surgery, vascularand endovascular medicine, neurointerventional radiology and surgery, emergency medicine and intensive care.

This book is a fully updated and revised second edition of a highly successful text in which a new concept of knowledge mining, based on explication and transfer of interventional knowledge of experts, has been implemented. The dedicated training program that is set out will serve the needs of all interventional operators, whether cardiologists, vascular surgeons, vascular specialists, or radiologists, enabling them to achieve a consistent expert level across the entire broad spectrum of catheter-based interventions. Operator skills - and in particular decision-making and strategic skills - are the most critical factors for the outcome of catheter-based cardiovascular interventions. Currently, such skills are commonly developed by the empirical trial and error method only. The explicit teaching, training, and learning approach adopted in this book permits the rapid transfer of interventional knowledge and enables individual operators to negotiate steep learning curves and acquire complex skills in a highly efficient manner. It will thereby offer invaluable assistance in meeting successfully the challenges of modern cardiovascular care.

Glossary -- Key equations -- -- Principles of echocardiographic image acquisition and Doppler analysis -- Normal anatomy and flow patterns on transthoracic echocardiography -- Transesophageal echocardiography -- Specialized echocardiography applications -- Clinical indications and quality assurance -- Left and right ventricular systolic function -- Ventricular diastolic filling and function -- Coronary artery disease -- Cardiomyopathies, hypertensive and pulmonary heart disease -- Pericardial disease -- Valvular stenosis -- Valvular regurgitation -- Prosthetic valves -- Endocarditis -- Cardiac masses and potential cardiac source of embolus -- Diseases of the great arteries -- The adult with congenital heart disease -- Intraoperative and interventional echocardiography -- Appendices. Normal values for echocardiographic measurements -- Evidence tables.

Introduction to hemodynamic assessment in the cardiac catheterization laboratory / Michael Ragosta -- Normal waveforms, artifacts and pitfalls / Michael Ragosta and Jamie L. W. Kennedy -- Cardiac output and shunt determination / Lawrence W. Gimple and Vishal Arora -- Mitral valve diseases / Michael Ragosta -- Aortic valve diseases / Michael Ragosta -- Hypertrophic cardiomyopathy and related conditions / Michael Ragosta -- Right sided heart disorders : hemodynamics of the tricuspid and pulmonic valves and right ventricle / Michael Ragosta -- Pulmonary hypertension and related disorders / LaVone A. Smith and Jamie L. W. Kennedy -- Pericardial disease and restrictive cardiomyopathy / Michael Ragosta -- Shock and heart failure / Angela M. Taylor -- Congenital heart disease / Michael R. Hainstock -- Coronary and peripheral arterial hemodynamics / Michael Ragosta.

This textbook is in line with the latest international thinking, guidelines and research findings in the field of neurology. The treatment guidelines used in the Netherlands and Belgium have been taken into account, thus making it a useful source of information in training and clinical practice. The reader is guided from basic concepts to complex physiology. The first nine chapters are devoted to the basic neurological sciences and provide a glimpse of clinical practice. The ensuing seventeen clinical chapters are based on the illness model, thus giving the reader an overview of a large number of neurological disorders. Each chapter begins with a case study which provides a practical context for the theory. The textbook also includes many tables and diagrams to clarify the concepts discussed. The Textbook of Clinical Neurology is also available online. Readers will find the entire content on the website, along with test questions, case studies, guidelines and other additional material. The textbook is designed for use in medical and paramedical training and is also suitable for programmes in nursing, human movement sciences, and medical biology. It serves as a reference for doctors and physiotherapists in clinical practice.

This textbook provides a comprehensive overview of the state of the art in otolaryngology, discussing all the newly advances in the subspecialties of head and neck, plastics, otology, laryngology, rhinology and pediatrics, and also addressing topics like allergy, sleep medicine, trauma, and the fundamentals of systemic diseases that frequently manifest in the head and neck region. The book is divided into 9 sections, presenting the recent literature concerning all the subspecialties in otolaryngology and providing the information necessary for readers to gain an understanding of the field of otolaryngology. Each chapter includes definitions, key points and take-home messages, to aid learning. Throughout the book, tips and key features are highlighted with boxes, tables and figures, which the reader can refer back to for quick revision. Above all, the book enables medical students, residents and junior specialists in the field of ENT to develop their learning and surgical skills.

Introduction to Sexual Medicine -- The History of Modern Sexual Medicine -- Surveys of Sexual Behavior and Sexual Disorders -- The Human Sexual Response Cycle -- Facilitators and Barriers in Sexual History Taking -- Biopsychosocial Evaluation of Sexual Dysfunctions -- Biopsychosocial Treatment of Sexual Dysfunctions -- Evaluation of Male Hypoactive Sexual Desire Disorder -- Treatment of Male Hypoactive Sexual Desire Disorder -- Evaluation of Female Sexual Interest/Arousal Disorder -- Treatment of Female Sexual Interest/Arousal Disorder -- Evaluation of Erectile Disorder -- Treatment of Erectile Disorder -- Evaluation of Female Orgasmic Disorder -- Treatment of Female Orgasmic Disorder -- Evaluation of Delayed Ejaculation -- Treatment of Delayed Ejaculation -- Evaluation of Premature Ejaculation -- Treatment of Premature Ejaculation -- Evaluation of Genito-Pelvic Pain/Penetration Disorder -- Treatment of Genito-Pelvic Pain/Penetration Disorder -- Evaluation and Treatment of Sexual Disorders due to Medical Conditions -- Evaluation and Treatment of Substance/Medication-Induced Sexual Dysfunction -- Evaluation and Treatment of Hypersexual Disorder and Other Sexual Dysfunctions -- Myths About Sexual Health -- Sex and Pharmacological Sexual Enhancement -- Sex and Natural Sexual Enhancement: Sexual Techniques, Aphrodisiac Foods, and Nutraceuticals -- Sex and Sexual Orientation -- Sex and the Heart -- Sex and Cancer -- Sex and Chronic Physical Illness -- Sex and Chronic Psychiatric Illness -- Sexual Emergencies -- Sex and Quality of Life -- Alternative Medicine Approaches in Sexual Medicine -- Future Directions in Sexual Medicine.

"Bridging the gap between medical and surgical specialties in critical care, Textbook of Critical Care, 8th Edition, offers a practical, multidisciplinary approach to the effective management of adult and pediatric patients in the ICU. An outstanding editorial team, led by world-renowned intensivist Dr. Jean-Louis Vincent, assisted by Dr. Frederick A. Moore and new editors Drs. Rinaldo Bellomo and John J. Marini, provides the evidence-based guidance you need to overcome a full range of practice challenges. A full-color art program, relevant basic science and key summary points in every chapter, and expert contributing authors from all over the world make this an indispensable resource for every member of the critical care team."--Provided by publisher.

"Cultural psychiatry deals with the impact of culture on causation, perpetuation and treatment of patients suffering with mental illness. The role of culture in mental illness is increasingly being recognised, and the misconceptions that can occur as a result of cultural differences can lead to misdiagnoses, under or over-diagnosis. This second edition of the Textbook of Cultural Psychiatry has been completely updated with additional new chapters on globalisation and mental health, social media and tele-psychiatry. Written by world-leading experts in the field, this new edition provides a framework for the provision of mental health care in an increasingly globalised world. The first edition of the Textbook of Cultural Psychiatry was commended in the BMA Book Awards in 2008 and was the recipient of the 2012 Creative Scholarship Award from the Society for the Study of Psychiatry and Culture"--Provided by publisher.

This book provides a pedagogical guide to dermatologic ultrasound. As in any imaging field, dermatologic ultrasound is dynamic, and the area expands with the release of new technology. This textbook is a mix of the essential knowledge necessary to start and a detailed update to the dermatologic ultrasound field. This book is divided into three sections: The Requisites, Ultrasound Features of Common Dermatologic Conditions, and Practicalities. The first section details the basic information needed in dermatologic ultrasound, including technical recommendations and dermatologic concepts. The second covers major dermatologic conditions and their ultrasound presentation, including benign and malignant skin tumors, pediatric conditions, nail entities, inflammatory conditions, infections and infestations, and aesthetics. The final section covers tips for reporting and interventional dermatologic ultrasound procedures.Chapters present substantial clinical, ultrasonographic, and histologic correlation, including algorithms to help discriminate different conditions. The book additionally includes 150 self-assessment questions (CME), multiple key points, a plethora of state-of-the-art images with probes that go from 18 to 70 MHz, and ultrasound videos. This is a must guide for physicians, residents, and students in radiology, dermatology, plastic surgery, and any professional who wants to brush up on the dermatologic ultrasound field.

Diabetes in its Historical and Social Context. The History of Diabetes Mellitus / Robert B Tattersall -- Classification and Diagnosis of Diabetes / Ambady Ramachandran, Chamukuttan Snehalatha, Arun Nanditha -- Epidemiology of Type 1 Diabetes / Lars C Stene, Jaakko Tuomilehto -- Epidemiology of Type 2 Diabetes / Ronald CW Ma, Peter CY Tong -- The Global Burden of Diabetes / Mohammed K Ali, Karla I Galaviz, Mary Beth Weber, KM Venkat Narayan -- Normal Physiology. Islet Function and Insulin Secretion / Peter M Jones, Shanta J Persaud -- Glucagon in Islet and Metabolic Regulation / Darleen Sandoval, Jenny Tong, David D' Alessio -- Mechanism of Insulin Action / Morris F White -- Control of Weight: How Do We Get Fat? / Arianne N Sweeting, Ian D Caterson -- Pathogenesis of Diabetes. Autoimmune Type 1 Diabetes / Shehab Alshiekh, Helena Elding Larsson, Sten-A Ivarsson, Ake Lernmark -- Other Disorders with Type 1 Phenotype / Alice PS Kong, Elaine YK Chow, Juliana CN Chan -- Abnormalities of Insulin Secretion and [beta]-Cell Defects in Type 2 Diabetes / Stefano Del Prato, Cristina Bianchi, Giuseppe Daniele -- Insulin Resistance in Type 2 Diabetes / Michael Roden, Kitt Petersen, Gerald Shulman -- Genetic Architecture of Type 2 Diabetes / Rashmi B Prasad, Leif Groop -- Metabolic Disturbances in Diabetes / Adrian Vella, Robert A Rizza -- Obesity and Diabetes / Hans Hauner -- The Microbiome and Diabetes / Amanda J Cox, Nicholas P West, Allan W Cripps -- Other Types of Diabetes. Monogenic Causes of Diabetes / Shivani Misra, Andrew T Hattersley -- Drug-Induced Diabetes / Charles D Ponte, Devra K Dang -- Endocrine Disorders that Cause Diabetes / Rachel E Jennings, Neil A Hanley -- Pancreatic Diseases and Diabetes / Ranjit Unnikrishnan, Viswanathan Mohan -- Managing the Patient with Diabetes. Clinical Presentations of Diabetes / Ee Lin Lim, Roy Taylor -- The Aims of Diabetes Care / Katharine D Barnard, Richard IG Holt -- Educating the Person with Diabetes / Ingrid Willaing, Michael Vallis -- Lifestyle Issues: Diet / Nicola Guess -- Lifestyle Issues: Exercise / Mimi Z Chen, Robert C Andrews -- Monitoring Diabetes / Andrew Farmer -- Drug Therapy: Special Considerations in Diabetes / Bernard MY Cheung, Ronald CW Ma -- Treatment of Diabetes. Insulin and Insulin Treatment / Stephen Gough, Parth Narendran -- New Technologies for Glucose Monitoring and Insulin Administration / David L Horwitz, David C Klonoff -- Oral Glucose-Lowering Agents / Clifford J Bailey, Andrew J Krentz -- Non-Insulin Parenteral Therapies / Tina Vilsbøll, Mikkel Christensen, Tina Jorsal, Filip K Knop -- How to Use Type 2 Diabetes Treatments in Clinical Practice: Combination Therapies / Silvio E Inzucchi, David R Matthews -- In-Hospital Treatment and Surgery in People with Diabetes / Ketan Dhatariya, June James -- Hypoglycemia in Diabetes / Philip E Cryer, Ana María Arbeláez -- Acute Metabolic Complications of Diabetes: Diabetic Ketoacidosis and the Hyperosmolar Hyperglycemic State / Niels Møller -- Microvascular Complications in Diabetes. Pathogenesis of Microvascular Complications / Allan Flyvbjerg -- Diabetic Retinopathy / Toke Bek -- Diabetic Nephropathy / Sally M Marshall, Allan Flyvbjerg -- Diabetic Peripheral and Autonomic Neuropathy / Dan Ziegler -- Macrovascular Complications in Diabetes. Pathogenesis of Macrovascular Complications in Diabetes / Stephen P Gray, Elyse Di Marco, Riccardo Candido, Mark E Cooper, Karin AM Jandeleit-Dahm -- Cardiovascular Risk Factors: Hypertension / Peter M Nilsson -- Diabetic Dyslipidemia and Risk of Cardiovascular Disease / Adie Viljoen, Supriya Joshi, Anthony S Wierzbicki -- Ischemic Heart Disease in Diabetes / Christoph H Saely, Kourosh Vathie, Heinz Drexel -- Congestive Heart Failure / Anna Norhammar, Isabelle Johansson, Inga S Thrainsdottir, Lars Rydén -- Cerebrovascular Disease / Colum F Amory, Jesse Weinberger -- Peripheral Vascular Disease / Henrik H Sillesen -- Other Complications of Diabetes. Foot Problems in People with Diabetes / Andrew JM Boulton -- Sexual Function in Men and Women with Diabetes / David Price -- Gastrointestinal Manifestations of Diabetes / Adil E Bharucha, Michael Camilleri -- Diabetes and Non-Alcoholic Fatty Liver Disease / Shivakumar Chitturi, Geoffrey C Farrell -- The Skin in Diabetes / Graham R Sharpe, Paul D Yesudian -- Bone and Rheumatic Disorders in Diabetes / Andrew Grey, Nicola Dalbeth -- Diabetes and Cancer: Evidence for Risk, Methodology and Implications / Ellena Badrick, Andrew G Renehan -- Diabetes and Infections / Clive S Cockram, Bonnie CK Wong -- Psychosocial Aspects of Diabetes. Psychological Factors and Diabetes Mellitus / Frans Pouwer, Jane Speight -- Psychiatric Disorders and Diabetes / Richard IG Holt, Leslie Citrome -- Social Aspects of Diabetes / Brian M Frier, Mark WJ Strachan -- Diabetes in Special Groups. Diabetes in Childhood / Shideh Majidi, Christine M Chan, Marian Rewers -- Adolescence and Emerging Adulthood: Diabetes in Transition / Rebecca K Snelgrove, Dayna E McGill, Lori MB Laffel -- Diabetes in Pregnancy / Tim Cundy -- Diabetes in Old Age / Ahmed H Abdelhafiz, Alan J Sinclair -- Diabetes at the End of Life / June James, Jean MacLeod, Robert Gregory -- Delivery and Organization of Diabetes Care. The Role of the Multidisciplinary Team Across Primary and Secondary Care / Samuel I Seidu, Kamlesh Khunti, Melanie J Davies -- Models of Diabetes Care Across Different Resource Settings / Naomi S Levitt, Sam Surka, Andrew Farmer, Bob Mash -- Future Directions. Future Drug Treatments for Type 1 Diabetes / Jennifer L Sherr, Eda Cengiz, Michelle A Van Name, Stuart A Weinzimer, William V Tamborlane -- Future Drug Treatments for Type 2 Diabetes / Clifford J Bailey -- Stem Cell Therapy in Diabetes / Angelo Avogaro, Gian Paolo Fadini -- Islet Transplantation / Angela Koh, Peter E Senior, AM James Shapiro -- Gene Therapy for Diabetes / Virginia Haurigot, Veronica Jimenez, Fatima Bosch -- Future Models of Diabetes Care / Sanjeev N Mehta, Robert A Gabbay.

The second edition of this illustrated book equips practitioners with all the information that they will require in order to perform echocardiography appropriately and to interpret findings correctly. After clear exposition of fundamentals of the examination technique via both the transthoracic and the transesophageal approach, the functional anatomy of all normal and pathologic thoracic structures as observed on echocardiography is presented in detail. A wide range of basic and advanced applications of echocardiography in the emergency, perioperative, and intensive care settings are then described. A final supplementary section considers further applications of ultrasound in the ICU, such as in patients with respiratory failure, trauma, or venous thrombosis. This edition has been extensively revised and updated and includes entirely new chapters on various techniques and applications. It will be a tremendous aid to current best practice for all intensivists, emergency physicians, and anesthesiologists who intend to use echocardiography and ultrasound for diagnosis and guidance of optimal management in the critically ill.

This textbook presents for the first time a comprehensive body of the latest knowledge in the field of neuropeptides and their action on energy balance. It contains a detailed and comprehensive account of the specific hypothalamic peptides in regards to their roles in energy balance, food intake control and co-morbidities, to better understand the patho-physiology of obesity. The textbook includes an examination the history of the evolution of human society from a thin to the obese phenotype and, within that context, how modern society habits and industrial food production did not respect the evolutionary trait resulting in changes in the energy balance set point. It provides a novel conceptualization of the problem of obesity when considering the biochemistry of peptide hormones and entertaining novel ideas on multiple approaches to the problems of energy balance, as well as demonstrates and explains why alterations in pro-hormone processing are paramount to understand metabolic disease. This text is excellent material for teaching graduate and medical school courses, as well as a valuable resource for researchers in biochemistry, cell, and molecular biology, neuroscientists, physician endocrinologists, and nutritionists.

This ninth edition of the Textbook of Family Medicine, edited by Drs. Robert E. Rakel and David P. Rakel, remains your #1 choice for complete guidance on the principles of family medicine, primary care in the community, and all aspects of clinical practice. Ideal for both residents and practicing physicians, this medical reference book includes evidence-based, practical information to optimize patient care and prepare you for the ABFM exam. A clean, quick-reference layout makes it easy for you to put information to work immediately in your practice.

History of the international society for the study of women's sexual health / Sue W. Goldstein -- Sexual medicine education and training / Sharon J. Parish and Johannes Bitzer -- Nosology and epidemiology of hypoactive sexual desire disorder / Leonard R. Derogatis -- Central nervous system anatomy and neurochemistry of sexual desire / James G. Pfaus and Sherri L. Jones -- Psychological management of hypoactive sexual desire disorder / Sheryl A. Kingsberg and Stanley Althof -- Pathophysiology and medical management of hypoactive sexual desire disorder / Anita H. Clayton and Linda Vignozzi -- Nosology and epidemiology of arousal disorders in women / Leonard R. Derogatis -- Anatomy and physiology of arousal / Kwangsung Park and Noel N. Kim -- Psychological management of arousal disorders / Isbelia Segnini and Tuuli M. Kukkonen -- Pathophysiology and medical management of female genital arousal disorder / Irwin Goldstein -- Pathophysiology and medical management of persistent genital arousal disorder / Barry R. Komisaruk and Irwin Goldstein -- Nosology and epidemiology of female orgasm disorder / Leonard R. Derogatis -- Peripheral and central neural bases of orgasm / Emmanuele A. Jannini, Nan Wise, Eleni Frangos, Barry R. Komisaruk -- Psychological management of orgasm disorders / Sara Nasserzadeh -- Musculoskeletal management of female orgasm disorder / Karen Brandon -- Pathophysiology and medical management of female orgasm disorder / Irwin Goldstein and Barry Komisaruk -- Pathophysiology and medical management of female orgasmic illness syndrome / Irwin Goldstein and Barry R. Komisaruk -- Nosology and epidemiology of dyspareunia and vulvodynia / Tami S. Rowen and Andrew T. Goldstein -- Anatomy and physiology of sexual pain / Melissa A. Farmer -- Psychological management of provoked vestibulodynia / Caroline F. Pukall and Sophie Bergeron -- Musculoskeletal management of pelvic and sexual pain disorders / Sara K. Sauder, Fiona McMahon, and Amy Stein -- Medical management of dyspareunia and vulvovaginal pain / Andrew T. Goldstein and Susan Kellogg Spadt -- Future developments and research / James A. Simon.

This textbook discusses core principles and practices in gastrointestinal oncology and covers a wide range of practice areas such as pathology and radiologic images, epidemiology, genetics, staging, multidisciplinary management of specific gastrointestinal cancer, and pathology for each primary tumor site. The comprehensive coverage makes Textbook of Gastrointestinal Oncology a useful resource for the practitioner wishing to gain a greater understanding of the principles of managing malignant gastrointestinal disease, as well as medical oncology fellows, surgeons, radiation oncologists, gastroenterologists and fellows, and residents.

"H1N1. Diabetes. Ebola. Zika. Each of these health problems is rooted in a confluence of social, political, economic, and biomedical factors that together inform our understanding of global health. The imperative for those who study global health is to understand these factors individually and, especially, synergistically. Fully revised and updated, this fourth edition of Oxford's Textbook of Global Health offers a critical examination of the array of societal factors that shape health within and across countries, including how health inequities create consequences that must be addressed by public health, international aid, and social and economic policymaking"--Provided by publisher.

This textbook addresses the growing international need for a practical manual that teaches physicians how to apply cold atmospheric pressure plasma (CAP) in the day-to-day provision of patient healthcare. The book introduces readers to the concept of CAP, how it works, and how safe it is, before describing several diseases and other medical indications for its application. The book subsequently provides guidelines for daily clinical practice, e.g. for treating chronic wounds, decontaminating infected skin lesions, and rendering multi-resistant bacteria inert, as well as a detailed overview of plasma devices. In closing, it addresses organizational aspects, which are essential to cultivating and maintaining quality standards in the application of cold medical plasma. This textbook offers a unique educational resource and provides relevant information on plasma medicine as an emerging multidisciplinary discipline. Practitioners will appreciate this integrated, comprehensive guide, which is also suitable for advanced students of medicine and dentistry, and for nurses serving on plasma-assisted medical teams.

Hand eczema is a major complaint worldwide and a frequent occupational disorder. This book provides a comprehensive and detailed overview of the classification, etiology, diagnosis, prevention, and therapy of hand eczema. It is innovative, up to date, and practical. The links with particular occupations are explained, the various diagnostic tests are presented, and the role of different topical and systemic treatments is clearly described. The authors are world leaders in the field. The Textbook of Hand Eczema reflects a new era in hand dermatitis and will be invaluable for all who deal with the condition in their clinical practice.

Sinonasal Tract -- Anatomy and Histology -- Sinonasal Tract, Nonneoplastic -- Sinonasal Tract, Benign -- Sinonasal Malignancies -- Nasopharynx and skull base.