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  • Book
    Eric Barret, Matthieu Durand, editors.
    Summary: Focal therapy is a promising option for selected patients who have localized low or intermediate-risk prostate cancer, providing a compelling alternative between active surveillance and radical therapies by targeting the index lesion and preserving as much tissue as possible. Numerous cohort studies have already investigated multiple focal techniques, such as cryotherapy, high-intensity focused ultrasound, brachytherapy, photodynamic therapy, laser therapy, irreversible electroporation and cyberknife methods, all of which have demonstrated positive oncological outcomes with 70 to 90 % negative follow-up biopsy. These various ablative techniques have produced only minor side-effects concerning urinary function, a low rate of erectile dysfunction, and have demonstrated a limited rectal toxicity. As a result, the primary end-point has now shifted and a new strategy needs to be established for patient follow-up and for defining treatment failure. Written by international experts in the field, this book is mainly focused on new techniques, all of which are amply illustrated. Technical Aspects of Focal Therapy in Localized Prostate Cancer will be of great practical value to all urologists and oncologists.

    Contents:
    Rational for Focal Therapy
    Concept of Index lesion
    Definition and Principles of Focal Therapy
    Eligibility for Focal Therapy: Patient Selection
    Imagingfor Focal Therapy
    Biopsies strategy
    Focal Cryotherapy
    Focal HIFU
    Focal Brachytherapy
    Focal PhotoDynamic Therapy
    Focal Laser Thermal Therapy
    Cyberknife Focal Therapy
    New Energies
    Follow-up after Focal Therapy
    Failure or Recurrence Management
    Focal Therapy Limitations
    Perspective
    Conclusion.
    Digital Access Springer 2015