BookMadhumita Roy, Amitava Datta.
Summary: The book discusses cancer and the potential use of phytochemicals as cancer therapeutics. It begins with the basics of cancer, including the definition, types, etiology and molecular mechanisms involved, before discussing the fundamentals of diagnosis, treatment and associated problems as well as remedial measures. Since cancer is not a single disease, and the mechanisms of carcinogenesis are different for different cancers, it examines the genes and proteins involved in carcinogenesis, and signal transduction pathways for each individual cancer type. Further, the book reviews the latest research on phytochemicals for cancer treatment, highlighting their anti-cancer properties, sources, structure, active biomolecules and probable mechanisms of action, and describing their biochemical properties in the context of cancer prevention and treatment.
Contents:
Intro; Foreword; Preface; Contents; About the Authors; 1 Cancer: Types and Hallmarks; 1.1 What Is Cancer?; 1.1.1 Types of Cancer; 1.1.1.1 Carcinoma; 1.1.1.2 Sarcoma; 1.1.1.3 Leukemia; 1.1.1.4 Lymphoma; 1.1.1.5 Myeloma; 1.1.1.6 Melanoma; 1.1.1.7 Brain and Spinal Cord Tumors; 1.2 Hallmarks of Cancer; 1.2.1 Sustaining Proliferative Signaling; 1.2.2 Evading Growth Suppressors; 1.2.2.1 Disruption of Contact Inhibition; 1.2.3 Resisting Cell Death; 1.2.4 Enabling Replicative Immortality; 1.2.5 Inducing Angiogenesis; 1.2.6 Activating Invasion and Metastasis; 1.2.7 Reprogramming Energy Metabolism 1.2.8 Evading Immune Destruction1.2.9 Genetic Instability and Mutation; 1.2.10 Tumor-Promoting Inflammation; 1.3 Cancer Diagnosis and Treatment; 1.3.1 Risk Factors and Causes of Cancer; 1.3.2 Symptoms; 1.3.3 Diagnosis; 1.3.3.1 Biopsy; 1.3.3.2 Imaging; 1.3.4 Treatment; 1.4 Conclusion; References; 2 Cancer: Genetics and Important Pathways; 2.1 Introduction; 2.2 Degree of Gene Mutations in Tumorigenesis; 2.3 Driver and Passenger Mutations; 2.4 Cancer-Specific Genomic Landscapes; 2.4.1 Genomic Landscape of Breast Cancer; 2.4.1.1 Summary; 2.5 Genomic Landscape of Other Cancers 3.5 Classification of Phytochemicals3.5.1 Phenolics; 3.5.1.1 Phenolic Acids; 3.5.1.2 Tannins; 3.5.1.3 Stilbenes; 3.5.1.4 Coumarins; 3.5.2 Flavonoids; 3.5.3 Carotenoid; 3.5.4 Alkaloid; 3.5.5 Nitrogen-Containing Compounds; 3.5.6 Organosulfur Compounds; 3.5.7 Benefits of Dietary Phytochemicals; 3.6 Conclusion; References; 4 Drugs and Phytochemicals; 4.1 Introduction; 4.2 Classification of Chemotherapy Drugs; 4.2.1 Alkylating Agents; 4.2.2 Antimetabolites; 4.2.3 Antitumor Antibiotics; 4.2.4 Topoisomerase Inhibitors; 4.2.5 Mitotic Inhibitors; 4.2.6 Corticosteroids 4.3 Mode of Action of Chemotherapeutic Drugs4.4 Benefits of Plant-Derived Medicines; 4.5 Plant-Derived Anticancer Drugs; 4.6 Other Phytochemicals as Anticancer Agents; 4.7 Conclusion; References; 5 Molecular Mechanisms of Phytochemical Actions in Cancer; 5.1 Introduction; 5.2 Epigenetic Control; 5.2.1 Histone Modification; 5.2.2 DNA Methylation; 5.2.3 miRNAs; 5.3 Keap1-Nrf2 Pathway; 5.4 Oxidative Stress; 5.5 Inflammation; 5.6 Roles of Dietary Phytochemicals in Oxidative Stress; 5.6.1 Phytochemicals and Oxidative Stress; 5.6.1.1 Phenolic Phytochemicals and Oxidative Stress