BookCynthia V. Rider, Jane Ellen Simmons, editors ; foreword by Linda S. Birnbaum.
Summary: Exposure to multiple chemical and nonchemical stressors is the rule, not the exception. Nevertheless, it continues to be a significant challenge in toxicology and risk assessment to thoroughly take mixtures into account. In this book, both basic and advanced concepts for considering mixtures are discussed, from initial-exposure characterization through the evaluation of risk associated with combined exposures. Several chapters also examine the adoption of promising tools from other disciplines. Looking beyond chemical mixtures, the discussion also addresses incorporating nonchemical stressors into toxicity studies and cumulative-risk assessments. This "excellent" volume--as described by Linda S. Birnbaum, Director of the National Institute of Environmental Health Sciences and the National Toxicology Program, in her foreword to the book--forms "a comprehensive picture of the current state of mixtures science." With contributions from a host of established experts, Chemical Mixtures and Combined Chemical and Nonchemical Stressors: Exposure, Toxicity, Analysis, and Risk is an essential text for mixtures researchers in the fields of toxicology, epidemiology, exposure science, risk assessment, and statistics. Both seasoned mixtures researchers and those new to the field will appreciate the clear explanations of mixtures concepts as well as the comprehensive presentation of available tools for predicting mixture effects and estimating risk from combined exposures. This volume also serves as a useful reference book for students.
Contents:
Introduction
Combined exposures
Biomonitoring to assess exposures to mixtures of environmental chemicals
Considerations for measuring exposures to chemical mixtures
Modeling complex exposures
Prioritizing mixtures for study
Introduction to environment and exposome-wide association studies: A data-driven method to identify multiple environmental factors associated with phenotpyes in human populations
Ecological assembly of chemical mixtures
Adverse outcome pathways to support the assessment of chemical mixtures
Toxicology
Dose-response modeling
Predicting mixture toxicity with models of additivity
Mixtures: contrasting perspectives from toxicology and epidemiology
Comparing predicted additivity models to observed mixture data
Physiologically based parmacokinetic modeling of chemical mixtures
Mixture experimental design
Chemical mixtures risk assessment
Component-based risk assessment approaches with addivity and interactions
Assessing human health risks using information on whole mixtures
Nonchemical stressors
Consideration of physical stressors in cumulative risk assessment
Psychosocial and chemical stressors
Community-based cumulative impact assessment: California's approach to integrating nonchemical stressors into environmental assessment practices.