BookHirohiko Tsujii, Tadashi Kamada, Toshiyuki Shirai, Koji Noda, Hiroshi Tsuji, Kumiko Karasawa, editors.
Summary: This book serves as a practical guide for the use of carbon ions in cancer radiotherapy. On the basis of clinical experience with more than 7,000 patients with various types of tumors treated over a period of nearly 20 years at the National Institute of Radiological Sciences, step-by-step procedures and technological development of this modality are highlighted. The book is divided into two sections, the first covering the underlying principles of physics and biology, and the second section is a systematic review by tumor site, concentrating on the role of therapeutic techniques and the pitfalls in treatment planning. Readers will learn of the superior outcomes obtained with carbon-ion therapy for various types of tumors in terms of local control and toxicities. It is essential to understand that the carbon-ion beam is like a two-edged sword: unless it is used properly, it can increase the risk of severe injury to critical organs. In early series of dose-escalation studies, some patients experienced serious adverse effects such as skin ulcers, pneumonitis, intestinal ulcers, and bone necrosis, for which salvage surgery or hospitalization was required. To preclude such detrimental results, the adequacy of therapeutic techniques and dose fractionations was carefully examined in each case. In this way, significant improvements in treatment results have been achieved and major toxicities are no longer observed. With that knowledge, experts in relevant fields expand upon techniques for treatment delivery at each anatomical site, covering indications and optimal treatment planning. With its practical focus, this book will benefit radiation oncologists, medical physicists, medical dosimetrists, radiation therapists, and senior nurses whose work involves radiation therapy, as well as medical oncologists and others who are interested in radiation therapy.
Contents:
Part I. The History of Carbon-Ion Radiotherapy
1. History of Charged Particle Radiotherapy / Hirohiko Tsujii
Part II. An Overview of Carbon-Ion Radiotherapy
2. The Characteristics of Carbon-Ion Radiotherapy / Tadashi Kamada
3. Overview of the Heavy-Ion Medical Accelerator in Chiba (HIMAC) Practices / Tadashi Kamada
Part III. Radiobiology of Carbon-Ion Radiotherapy
4. Heavy-Ion Radiobiology / Yoshiya Furusawa
5. Biophysical Models and RBE / Naruhiro Matsufuji
Part IV. Carbon-Ion Radiotherapy System
6. Workflow of Carbon-Ion Radiotherapy / Toshiyuki Shirai and Yuka Takei
7. Beam-Delivery Systems / Shigekazu Fukuda, Takuji Furukawa, and Yoshiyuki Iwata
8. Dosimetry / Manabu Mizota and Akifumi Fukumura
9. Motion Management / Shinichiro Mori
10. Quality Assurance / Takuji Furukawa and Shinichiro Mori
Part V. Treatment Planning of Carbon-Ion Radiotherapy
11. Treatment Planning of Carbon-Ion Radiotherapy / Nobuyuki Kanematsu and Taku Inaniwa
Part VI. Facility Design
12. Facility Design of Carbon-Ion Radiotherapy / Koji Noda
Part VII. Oncology Information System
13. Oncology Information System / Yutaka Ando
Part VIII. Evaluation of Treatment Outcome
14. Evaluation of Treatment Outcomes Using the Heavy-Ion Medical Accelerator in Chiba (HIMAC) Approach / Tadashi Kamada
Part IX. Head and Neck Tumors
15. Cancer of the Head and Neck / Azusa Hasegawa
16. Malignant Melanoma of the Head and Neck / Ryo Takagi
17. Soft Tissue Sarcoma of the Head and Neck / Masashi Koto
Part X. Skull Base and Paracervical Tumors
18. Skull Base and Upper Cervical Spine Tumors / Masashi Koto
Part XI. Eye Tumors
19. Uveal Melanoma / Hiroshi Tsuji, Shingo Toyama, and Takuma Nomiya
20. Lacrimal Gland Tumors / Hiroshi Tsuji, Nobutaka Mizoguchi, and Takuma Nomiya
Part XII. Lung Tumors
21. Lung Cancer / Naoyoshi Yamamoto and Mio Nakajima
22. Metastatic Lung Tumors and Lymph Nodes / Naoyoshi Yamamoto and Mio Nakajima
Part XIII. GI Tract Tumors
23. Esophageal Cancer / Shigeo Yasuda
24. Postoperative Recurrence of Rectal Cancer / Shigeu Yamada, Satoshi Endo, Kohtaro Terashima, Makoto Shinoto, Shigeo Yasuda, Miho Shiomi, and Tetsuro Isozaki
Part XIV. Liver Tumors
25. Hepatocellular Carcinoma / Shigeo Yasuda
Part XV. Pancreatic Cancer
26. Pancreatic Cancer / Shigeu Yamada, Kohtaro Terashima, Makoto Shinoto, Shigeo Yasuda, Miho Shiomi, and Tetsuro Isozaki
Part XVI. Genitourinary Tumors
27. Prostate Cancer / Hiroshi Tsuji, Hitoshi Ishikawa, and Takuma Nomiya
28. Renal Cell Carcinoma / Takuma Nomiya and Hiroshi Tsuji
Part XVII. Gynecologic Tumors
29. Uterine Cancer / Masaru Wakatsuki
30. Gynecological Melanoma / Kumiko Karasawa
Part XVIII. Bone and Soft Tissue Sarcomas
31. Bone and Soft-Tissue Sarcomas / Reiko Imai
Part XIX. Other Tumors
32. Previously Irradiated Tumors / Masashi Koto
33. Metastatic Tumors / Kumiko Karasawa
34. Brain Tumors / Masashi Koto
35. Breast Cancer / Kumiko Karasawa.