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  • Book
    Hervé Tettelin, Duccio Medini, editors.
    Summary: This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The books respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.

    Part 1: Genomic diversity and the pan-genome concept
    Chapter 1: The pan-genome: a data-drivendiscovery in biology
    Chapter 2: The prokaryotic species concept and challenges
    Chapter 3: Bacterial guide on how to design a diversified gene portfolio
    Chapter 4: A review of pan-genome tools and recent studies
    Part 2: Evolutionary biology of pan-genomes
    Chapter 5: Structure and dynamics of bacterial populations: pan-genome ecology
    Chapter 6: Bacterial microevolution and the pan-genome
    Chapter 7: Pan-genomes and selection: the public goods hypothesis
    Chapter 8: A pan-genomic perspective on the emergence, maintenance and predictability of antibiotic resistance
    Part 3: Pan-genomics: an open, evolving discipline
    Chapter 9: Metapangenome: at the crossroad of pangenomics and metagenomics
    Chapter 10: Pan-genome flux balance analysis towards pan-phenomes
    Chapter 11: Bacterial epigenomics: epigenetics in the age of population genomics
    Chapter 12: Eukaryotic pan-genomes
    Chapter 13: Computational strategies for eukaryotic pan-genome analyses.
    Digital Access Springer 2020