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  • Book
    C. Simon Herrington, editor.
    Summary: This is the third volume in the Essentials of Diagnostic Gynecological Pathology series sponsored by the British Association of Gynecological Pathologists. Focusing on cervical pathology, it provides an update on current diagnostic criteria, the use of biomarkers and specimen handling. It serves as a quick desktop reference facilitating accurate diagnosis, and also provides detailed descriptions and an exhaustive reference list for more in-depth study. Sections devoted to the changing landscape of cervical screening, current management and future directions are included. Standardized terminology, the biology of HPV-related pre-invasive disease, and the staging of early cervical cancers are discussed. As most histopathology departments receive many gynecological specimens, Pathology of the Cervix has been written to be useful diagnostically to general as well as specialist gynecological pathologists and pathologists in training. Gynecologists, oncologists, dermatologists, genitourinary physicians and cancer nurse specialists will find expert insights here that will help in treatment and counselling of their patients.

    Contents:
    Preface; Preface to the Series; Contents; Contributors; 1: Development of the Uterine Cervix and Its Implications for the Pathogenesis of Cervical Cancer; Introduction; Development of the Lower Female Reproductive Tract; Immunophenotypic Characterization of the Developing Human Fetal Squamocolumnar Junction; Progenitor Cells in the Adult Squamocolumnar Junction; Definition of the Cervical Transformation Zone (TZ); Squamous Metaplasia; Potential Target Cells for HPV Infection; Premalignant Lesions; Low-Grade Squamous Intraepithelial Lesion (LSIL). High-Grade Squamous Intraepithelial Lesion (HSIL) Adenocarcinoma In Situ (AIS); References; 2: Human Papillomaviruses (HPVs); Introduction; Classification; HPV Genome Organization and Life Cycle; Epidemiology; Prevalence in the General Population; Clearance and Risk; Prevalence in Disease (Histological); Prevalence in Disease (Cytologically Defined); Host Defenses; HPV Immunization; Delivery and Immunogenicity; Therapeutic Vaccines; Impact (Prophylactic Vaccines); HPV Testing; Justification for HPV Testing; Targets and Types of HR-HPV Test. Tools and Biomarkers for the Risk Stratification of HR-HPV Infection HPV Testing in Various Biospecimens; HPV Testing in Immunized Populations; References; 3: Cervical Screening: History, Current Algorithms, and Future Directions; Principles of Screening; The Condition; The Test; The Treatment; The Screening Program; Epidemiology of Cervical Cancer; Papanicolaou and the Development of Cytology-Based Population Screening; Cervical Cancer Screening in the UK (1950-1985); UK Terminology of Cervical Cytology and Histology; The NHS Cervical Screening Program (1986-2004). NHSCSP 2004 to the Present Liquid-Based Cytology (LBC); HPV Testing; Triage of Low-Grade Abnormality; Test of Cure; Automation in Cervical Screening; NHSCSP Beyond 2016: Cervical Screening in the Era of HPV Vaccination; HPV Vaccination; Primary HPV Testing; References; 4: Surgical and Nonsurgical Management of Cervical Cancer: Current Practice and Future Directions; Introduction; Stage IA Carcinoma of the Cervix; Stage IA1: Invasive Lesion d" mm Wide and d" mm Deep; Stage IA1 Plus Lymphovascular Space Invasion; Stage IA2: Width d"7 mm and Depth> 3 mm But d" mm. Adenocarcinoma Versus Squamous Cell Carcinoma in Early Cervical Cancer Stage IB1 Carcinoma of the Cervix; Stage IB1: Depth>5 mm, Or Width>7 mm, But Tumour Less Than 4 cm Diameter; or a Clinically Visible Lesion Confined to the Cervix; Stage IB1: Diameter Less Than 1 cm; Stage IB1: 1-2 cm Diameter Tumor; Trachelectomy; Stage IB1: 2-4 cm in Diameter; Stage IB2
    IV Carcinoma of the Cervix; Reducing the Risks of Treatment; Strategy 1: Assess the Risk of Recurrence Prior to Undertaking Surgical Treatment; Strategy 2: Lymph Node Assessment; Strategy 3: Radical Surgical Techniques.
    Digital Access Springer 2017