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  • Book
    Shantanu Bhattacharya, Sanjay Kumar, Avinash K Agarwal, editors.
    Summary: This volume provides an overview of the recent advances in the field of paper microfluidics, whose innumerable research domains have stimulated considerable efforts to the development of rapid, cost-effective and simplified point-of-care diagnostic systems. The book is divided into three parts viz. theoretical background of paper microfluidics, fabrication techniques for paper-based devices, and broad applications. Each chapter of the book is self-explanatory and focuses on a specific topic and its relation to paper microfluidics and starts with a brief description of the topics physical background, essential definitions, and a short story of the recent progress in the relevant field. The book also covers the future outlook, remaining challenges, and emerging opportunities. This book shall be a tremendous up-to-date resource for researchers working in the area globally.

    Intro; Preface; Contents; About the Editors; 1 A Historical Perspective on Paper Microfluidic Based Point-of-Care Diagnostics; Abstract; 1.1 Introduction; 1.2 Paper Microfluidics: Historical Perspective; 1.3 Outline; References; 2 Fluid Transport Mechanisms in Paper-Based Microfluidic Devices; Abstract; 2.1 Introduction; 2.2 Fluid Transport; 2.2.1 Classical Lucas-Washburn Equation (Capillary Flow); 2.2.2 Darcy's Law for Fluid Flow; 2.2.3 Fluid Transport in the Porous Media of Varying Cross Section/Arbitrary Shape; 2.2.4 Radial Fluid Transport in Porous Media 2.2.5 Diffusion-Based Fluid Transport; 2.2.6 Lateral Flow Immunoassay (LFIA); 2.3 Summary; References; 3 Fabrication Techniques for Paper-Based Microfluidic Devices; Abstract; 3.1 Introduction; 3.2 Fabrication Methods; 3.2.1 2D Fabrication Methods; 3.2.2 Flexographic Printing; 3.2.3 3D Fabrication Methods; 3.3 Comparison of Various Fabrication Methods; References; 4 Flow Control in Paper-Based Microfluidic Devices; Abstract; 4.1 Introduction; 4.2 Fluid Flow Through Porous Substrates; 4.2.1 Lucas-Washburn Equation; 4.2.2 Darcy's Equation for Fluid Flow 4.2.3 Richard's Equation for Partially Saturated Flows; 4.3 Controlling the Fluid Flow in Paperfluidic Devices; 4.3.1 Techniques to Achieve Flow Control Without Valves; Changing the Channel Dimensions; Creation of Alternate Flow Paths; Changing the Surface Wettability; Changing the Properties of the Porous Substrate; Increasing the Resistance to Fluid Flow Using Physicochemical Barriers; Electrostatic Interactions Between Device Components; Varying the Channel Dimensions for Specific Introduction of Reagents 4.3.2 Techniques to Achieve Flow Control Utilizing Valve-Like Tools; Dissolvable Species; Mechanical Tools Which Connect or Disconnect Channels; Wax-Based Valves; Fluidic Diodes; Automatically Actuated External Valves; 4.4 Challenges to Translation of Flow Control-Based Paperfluidic Devices; References; 5 Paper Microfluidic Based Device for Blood/Plasma Separation; Abstract; 5.1 Introduction; 5.2 Physiological Hemodynamics and Porous Media Hemodynamics; 5.3 Recent Advances in Paper Based Blood Plasma Separation Devices; 5.4 Summary and Future Perspectives
    Digital Access Springer 2019