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  • Book
    Nicola J. Curtin, Ricky A. Sharma, editors.
    Contents:
    History of the discovery of poly (ADP-ribose)
    Discovery of the PARP superfamily and focus on the lesser exhibited but not lesser talented members
    The role of PARPs in DNA Strand Break Repair
    TIPs: Tankyrase Interacting Proteins
    PARP and Carcinogenesis
    Multitasking roles for poly(ADP-ribosyl)ation in aging and longevity
    Overview of PARP Inhibitor Design and Optimization
    Structure Based Design of PARP Inhibitors
    Preclinical chemosensitization by PARP inhibitors
    Classification of PARP inhibitors based on PARP trapping and catalytic inhibition, and rationale for combinations with topoisomerase I inhibitors and alkylating agents
    Radiosensitisation by poly(ADP-ribose) polymerase inhibition
    The vasoactivity of PARP inhibitors
    Synthetic lethality with Homologous Recombination Repair defects
    Targeting tumour hypoxia with PARP Inhibitors: Contextual synthetic lethality
    Other determinants of sensitivity
    Synthetic sickness with molecularly targeted agents against the EGFR pathway
    Disruption of DNA repair by cell cycle and transcriptional CDK inhibition
    Resistance to PARP Inhibitors Mediated by Secondary BRCA1/2 Mutations
    PARP inhibitor resistance
    what is beyond BRCA1 or BRCA2 restoration
    Introduction to PARPi clinical trials and future directions
    Clinical trials investigating PARP inhibitors as single agents
    Clinical trials of PARP inhibitors with chemotherapy
    Combination of PARP inhibitors with clinical radiotherapy
    Biomarkers for PARP Inhibitors.
    Digital Access Springer 2015