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  • Book
    Olivier Glehen, Aditi Bhatt, editors.
    Summary: This book covers some well-known and some unexplored pathological aspects of management of peritoneal metastases and should be read by both surgeons and pathologists involved in the management of peritoneal surface malignancies. The evaluation of cytoreductive surgery specimens is explored for the prognostic information it can provide and recommendations for evaluation of such specimens are provided. The pathways and patterns of peritoneal dissemination and their clinical implications on the extent of surgery performed and other aspects of management are discussed for some common peritoneal tumours. The exploratory studies presented here provide a new perspective on the surgical resection of peritoneal metastases. Other important aspects of pathological evaluation like pathological response to chemotherapy, diagnosis and classification of rare peritoneal tumors have also been covered in different chapters. Keeping in sync with the progress in molecular oncology, the role of molecular oncology in the current and future management of peritoneal metastases is addressed for different tumors. .

    About the Editors
    1: Mechanisms of Peritoneal Metastasis Formation
    1.1 Introduction
    1.2 Mechanisms of Trans-mesothelial Metastasis
    1.2.1 Mechanisms of Cancer Cell Spillage into the Peritoneal Cavity
    1.2.2 Adhesion of PFCCs and Mesothelial Cells (Fig. 1.1, Process 1)
    1.2.3 Morphological Changes of Mesothelial Cells (Fig. 1.1, Process 1), Submesothelial Invasion of PFCCs, Attachment of PFCCs to the Basement Membrane (Fig. 1.1, Process 2)
    1.2.4 Adhesion of PFCCS to the Submesothelial Basement Membrane (Fig. 1.1, Process 2 and Fig. 1.6) 1.2.5 Invasion into the Submesothelial Tissue (Fig. 1.1, Process 3)
    1.2.6 Destruction of Submesothelial Basement Membrane and Extracellular Matrix (ECM) and Invasion into Submesothelial Tissue (Fig. 1.1, Process 3)
    1.2.7 Proliferation in the Subperitoneal Tissue (Fig. 1.1, Process 4: Angiogenesis and Proliferation)
    1.3 Trans-lymphatic Metastasis
    1.4 Mechanisms of Superficial Growing Metastasis
    2: Extent of Peritoneal Resection for Peritoneal Metastases: Inferences from Pathophysiology
    2.1 Background and Introduction 2.1.1 Evolution of Peritoneal Surface Oncology
    2.2 Pathophysiology of Peritoneal Metastases and Its Clinical Implications
    2.2.1 Peritoneal Metastatic Cascade
    2.2.2 Distribution of Disease in the Peritoneal Cavity Epithelial Ovarian Cancer
    2.2.3 Implications of Mechanism of Peritoneal Dissemination on Surgical Resection
    2.2.4 Morphology of Peritoneal Deposits and Morphological Evolution of Peritoneal Metastases Morphological Evolution of PM Alteration in Morphology After Systemic Chemotherapy Histological Subtype 2.2.5 Impact on the Extent of Surgical Resection
    2.2.6 Resection of Uninvolved Regions
    2.2.7 Primary Tumor Type
    2.2.8 Lymphadenectomy in Addition to Cytoreductive Surgery
    2.2.9 Prognostic Implications of Lymph Node Involvement
    2.3 Extent of Peritoneal Resection for PM Arising from Various Primary Tumors
    2.3.1 Studies Looking at the Extent of Peritoneal Resection
    2.3.2 Application in Clinical Practice and Question for Future Research
    2.4 Conclusions
    3: Therapeutic Rationale and Data Set for Reporting Cytoreductive Surgery Specimens 3.1 Introduction
    3.2 Anatomical Considerations
    3.2.1 Peritoneal Regions
    3.2.2 Lymphatic Drainage
    3.2.3 Subperitoneal Nodes
    3.2.4 Omental Nodes
    3.2.5 Retroperitoneal Nodes
    3.2.6 Paracardiac and Mediastinal Nodes
    3.3 Pathological Evaluation of Cytoreductive Surgery Specimens
    3.3.1 The Surgeon's Role Labelling of Surgical Specimens by the Surgeon Morphological Description
    3.3.2 The Pathologist's Role Handling of Specimens by the Pathologist Gross Description and Sectioning
    Peritonectomy Specimen(s)
    Digital Access Springer 2020