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  • Book
    Roberto Scatena, editor.
    Summary: "At present there are a growing number of biomolecules under investigation to understand their potential role as cancer biomarker for diagnostic, prognostic and therapeutic purposes. Intriguingly, the state of art on cancer biomarkers research shows interesting and promising results together to clamorous failures. Also from a clinical point of view, there are contradictory results on routine clinical use of the present cancer biomarkers. Some patients may be simply monitored in their course by a periodic blood sample, but sometimes this monitoring shows dramatic limits. A lot of patients show serious and extensive relapses without significant change in serum concentrations of biomarkers tested. Often the physician who should utilize these biomarker does not entirely know their limits and the total potential applications as well and sometimes this knowledge is influenced by economical and marketing strategies. This limited and "polluted" knowledge may have dramatic consequences for patient. The aim of this book is to diffuse all aspects of cancer biomarkers, from their biochemical peculiarities to all clinical implications by passing through their physiology and pathophysiology. This critical approach towards old and new cancer biomarkers should foster a deepened and useful understanding of the diagnostic and prognostic index of these fundamental parameters of laboratory medicine and in the same time facilitating the research of new and more sensitive-specific signals of the cancer cell proliferation"--Back cover.

    Cancer biomarkers discovery and validation: state of the art, problems and future perspectives
    Use of biomarkers in screening for cancer
    The role of metabolomics in the study of cancer biomarkers and in the development of diagnostic tools
    The role of epigenomics in the study of cancer biomarkers and in the development of diagnostic tools
    Efficient, adaptive clinical validation of predictive biomarkers in cancer therapeutic development
    Prostate specific antigen as a tumor marker in prostate cancer: biochemical and clinical aspects
    The actual role of LDH as tumor marker, biochemical and clinical aspects
    Neuron-specific enolase as a biomarker: biochemical and clinical aspects
    Components of the plasminogen-plasmin system as biologic markers for cancer
    The role of human chorionic gonadotropin as tumor marker: biochemical and clinical aspects
    Biomarkers for hepatocellular carcinoma (HCC): an update
    Mucins and cytokeratins as serum tumor markers in breast cancer
    The role of CA 125 as tumor marker: biochemical and clinical aspects
    CA 19-9: biochemical and clinical aspects
    Non coding RNA molecules as potential biomarkers in breast cancer
    Urinary prostate cancer antigen 3 as a tumour marker: biochemical and clinical aspects
    Biomarker in cisplatin-based chemotherapy for urinary bladder cancer
    A critical approach to clinical biochemistry of chromogranin A
    The actual role of receptors as cancer markers, biochemical and clinical aspects: receptors in breast cancer
    The role of CTCs as tumor biomarkers.
    Digital Access Springer 2015