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  • Book
    Iago Dillion Lima Cavalcanti, José Cleberson Santos Soares.
    Summary: This work covers the pathophysiology of cancer, exploring the difficulty of optimal treatment due to the complexity and diversity of cancer types. The search for distinctive molecular biology characteristics of tumor cells is especially relevant in the identification of overexpressed receptors and proteins that can be used as a target for cancer treatment. We highlight the main therapeutic modalities, particularly conventional systemic chemotherapy, addressing its mechanisms of action, therapeutic classes and even the toxic effects. We also describe the main tumor markers, their importance in the diagnosis and treatment of cancer, and the specificity of tumor cells. The first chapters serve as an introduction to the central topic of this book, targeted therapy. Key aspects of target therapy, such as classes of drugs, immunotherapy, monoclonal antibodies, checkpoint inhibitors, cancer vaccines and tyrosine kinase inhibitors are presented, and, for each one, the benefits, as well as the adverse effects are reported. Chapter 6 compares conventional systemic chemotherapy and targeted therapy, identifies the risks and benefits and also the eligibility criteria for patient care. The possibility of targeted therapy replacing conventional chemotherapy is discussed while reviewing studies that demonstrate the benefits of combining both types of treatment. Finally, the introduction of pharmaceutical nanotechnology to improve antineoplastic agents is addressed in the last chapter and sets the direction for future research in cancer treatment. This is a valuable resource for many health professionals including physicians, pharmacists, nurses, researchers and students interested in the field of oncology.

    Contents:
    Introduction
    Cancer: concepts and epidemiology
    A brief history of cancer
    What is Cancer?
    Cancer Epidemiology
    Cancer development and immunology
    Cell cycle
    Cell cycle control: the function of cyclins
    Cancer triggering agents
    Proto-oncogenes
    Tumor suppressor genes
    Development of tumor mass
    Cancer Immunology
    Discovery of tumor markers
    Cancer diagnosis
    Impact of the discovery of tumor markers
    Main tumor markers for cancer diagnosis
    Alpha-fetoprotein (AFP)
    Human Chorionic Gonadotropin (SHCG)
    Mucin-like cancer-associated antigen (MCA)
    CA 15.3
    Carcinoembryonic antigen (CEA)
    Bladder tumor antigen (BTA)
    Telomerase
    Nuclear matrix protein (NMP 22)
    Cyfra 21.1
    Prostatic acid phosphatase (PAP)
    Prostate-specific antigen (PSA)
    CA 125
    CA 19.9
    p53
    CA 72.4
    K-ras
    HER2
    Cancer staging
    Conventional cancer treatment
    Therapeutic modalities of cancer
    Surgery
    Radiotherapy
    Antineoplastic chemotherapy
    Classification of antineoplastic agents by cycle
    Specific cycle antineoplastics
    Nonspecific antineoplastic agents
    Classification of antineoplastic agents by chemical structure and function
    Alkylating agents
    Antimetabolites
    Plant-derived antineoplastics
    Antitumor antibiotics
    Chemotherapy toxicity
    Hematological toxicity
    Liver toxicity
    Cardiac toxicity
    Anthracyclines
    Fluoropyrimidine
    Taxanes
    Pulmonary toxicity
    Neurological toxicity
    Renal toxicity
    Gastrointestinal toxicity
    Metabolic changes
    Targeted therapies in cancer treatment
    Overexpressed receptors on tumor cells
    Immunotherapy
    Monoclonal antibodies
    Types of monoclonal antibodies
    Side effects of monoclonal antibodies
    Checkpoint Inhibitors
    Side effects of checkpoint inhibitors
    Cancer Vaccines
    Vaccines in cancer prevention
    Vaccines for the treatment of cancer
    Non-specific immunotherapies
    Tyrosine kinase inhibitors
    Imatinib
    Gefitinib
    Erlotinib
    Sorafenib
    Dasatinib
    Nilotinib
    Lapatinib
    Adverse events of tyrosine kinase inhibitors
    Conventional chemotherapy vs. targeted therapy
    Differences between conventional chemotherapy and targeted therapy
    Risks and benefits of conventional chemotherapy compared to targeted therapy
    Eligibility criteria for the indication of the targeted therapy
    Side effects of targeted therapy
    Can targeted therapy replace conventional chemotherapy?
    Targeted therapy associated with conventional chemotherapy
    Pharmaceutical nanotechnology applied to cancer
    Pharmaceutical nanotechnology
    Classification of nanosystems
    Liposomes
    Micelles
    Polymeric nanoparticles
    Solid lipid nanoparticles
    Magnetic nanoparticles
    Metal nanoparticles
    Main functions of nanosystems in cancer
    Pharmaceutical nanotechnology in cancer diagnosis
    Pharmaceutical nanotechnology for cancer treatment.
    Digital Access Springer 2021