Books

Contents:
Introduction & overview of malaria and plasmodium / Virander S. Chauhan, Chetan E. Chitnis, Deepak Gaur
Exoerythrocytic development of plasmodium parasites / Volker T. Heussler, Annika Rennenberg, and Rebecca R. Stanway
Molecular basis of erythrocyte invasion by plasmodium merozoites / Deepak Gaur, Chetan E. Chitnis, Virander S. Chauhan
The biology of malaria transmission / Robert E. Sinden
Comparative and functional genomics of malaria parasites / Martine M. Zilversmit, Sittiporn Pattaradilokrat, and Xin-zhuan Su
Gene regulation : new insights and possible intervention strategies / Artur Scherf, Nicholas A. Malmquist, Rafael M. Martins, Shruthi S. Vembar, and Jose-Juan Lopez-Rubio
Molecular genetic approaches to malaria research / Brendan Elsworth, Mauro F. Azevedo, Brendan S. Crabb, and Paul R. Gilson
Transcriptomics and proteomics / Archna P. Gupta, Zbynek Bozdech, and Peter R. Preiser
The biochemistry of plasmodium falciparum : an updated overview / Hagai Ginsburg
Signaling in malaria parasites / Pushkar Sharma, and Sudhir Kumar
Membrane transport proteins as therapeutic targets in malaria / Sanjay A. Desai, Kempaiah Rayavara, Paresh Sharma, Sayeed K. Syed, Wang Nguitragool, and Praveen Balabaskaran Nina
The proteolytic repertoire of malaria parasites / Puran Singh Sijwali, and Philip J. Rosenthal
Development of medicines for the control and elimination of malaria / Jeremy N. Burrows, and Timothy N.C. Wells
Antimalarial drug resistance / Naman K. Shah, and Neena Valecha
Epidemiology of plasmodium falciparum malaria / Alberto L. García-Basteiro, Quique Bassat, and Pedro L. Alonso
Malaria pathogenesis / Bronner P. Gonzalves, Michal Fried, and Patrick E. Duffy
Host genetics / Thomas N. Williams
The immune response in mild and severe malaria : two sides of the same coin / Michael Waisberg, Peter D. Crompton, Louis H. Miller, and Susan K. Pierce
Progress in development of malaria vaccines / Chetan E. Chitnis, Deepak Gaur, and Virander S. Chauhan
Plasmodium vivax : insights on burden and patho-biology / Ivo Mueller, Quique Bassat, Marcus V.G. Lacerda, and Hernando A. del Portillo.

Summary: This book presents up-to-date information on the diagnosis and management of the spectrum of medical and surgical corneal diseases, with a special focus on new technology. The latest tools for diagnosing ocular surface disease, infectious keratitis, and ocular allergies are discussed, along with novel treatment options for these entities. The impact of progress in imaging and contact lens technology on the management of corneal conditions is fully described, and the efficacy of corneal collagen crosslinking for keratoconus and corneal ectasia is evaluated. Detailed attention is devoted to the latest surgical techniques, including lamellar keratoplasty, endothelial keratoplasty, keratoprosthesis, and laser-assisted penetrating keratoplasty. In addition, the role of the eye bank in facilitating corneal procedures is explained. Advances in Medical and Surgical Cornea is written by leading authorities who share a passion for effective, cutting-edge care. It will be invaluable for both experienced ophthalmologists and trainees.

Contents:
Diagnosis and treatment of ocular surface disease
Diagnosis and treatment of infectious keratitis (PCR, Confocal)
Diagnosis and treatment of ocular allergies
Imaging techniques for corneal disorders (non-infectious: KCN, ectasias: Pentacam, Schleimpflug, confocal, etc)
Contact lens technology for treatment of severe ocular surface disease and corneal ectasias
Collagen crosslinking for keratoconus
Anterior lamellar keratoplasty
Endothelial keratoplasty (DSEK and DMEK)
Keratoprosthesis (Boston and OOKP)
Laser assisted keratoplasty and post-keratoplasty management (AK?s)
Eye Banking: what the eye bank can do for you now (DMEK harvesting, Pre-cut, FLAK). .

Summary: The pace and sophistication of advances in medicine in the past two decades have necessitated a growing need for a comprehensive reference that highlights current issues in medicine. Each volume in the Current Issues in Medicine series is a stand⁰́₀alone text that provides a broad survey of various critical topics⁰́₄all accomplished in a user-friendly yet interconnected format. The series not only highlights current advances but also explores related topics such as translational medicine, regulatory science, neglected diseases, global pandemics, patent law, immunotoxicology, ethics, theranostics, big data, artificial intelligence, novel imaging tools, combination drug products, and novel therapies. While bridging the gap between basic research, medicine, engineering, FDA law, intellectual property law, and regulatory science, the series provides a thorough understanding of medicine's potential to address health problems from both the patient⁰́₉s and the provider's perspectives in a healthcare setting. The range of topics covered, and the expertise of the contributing authors accurately reflect the rapidly evolving areas within medicine⁰́₄from basic medical sciences to clinical specialties. Current Issues in Medicine is essential reading for physicians, medical students, nurses, fellows, residents, undergraduate and graduate students, educators, policymakers, and biomedical researchers. The book⁰́₉s multidisciplinary approach makes it a valuable reference resource for the pharmaceutical industry, academia, and governments globally. However, unlike other series on medicine or medical textbooks, this series focuses on current trends, perspectives, and issues in medicine that are central to healthcare delivery in the 21st century.Volumes 1 and 2 in this series are focused on the current issues in basic medical science, subjects that are fundamental to the practice of medicine. These subjects are traditionally taught in the first two years of medical school that precede clinical instruction and training. They provide a core of basic knowledge critical to the success in clinical medicine during rotations through surgery, internal medicine, and the other specialties of medicine. Obviously, knowledge gleaned from these subjects leads to better ways to predict, prevent, diagnose, and treat disease. Specifically, volume 1 covers biochemistry, genomics, physiology, and pharmacology. Clinical specialties are covered in Volume 3. Volume 4 is directed towards diagnosis and imaging techniques, volume 5 focuses on drug delivery, and volume 6 highlights novel therapeutics and clinical applications.

Contents:
Cover
Half Title
Title Page
Copyright Page
Dedication
Table of Contents
Corresponding Authors
Note from the Series Editor
Engraving of the Bust of Hippocrates
Papyrus Fragment Showing the Hippocratic Oath
Facade of the Temple of Asclepius
Chapter 1: The Age of COVID-19: Medical Facts and Fiction
1.1: Emerging Pathogens: A Clear and Present Danger
1.2: SARS-CoV-2: Structure and Pathogenesis
1.3: Origin of SARS-CoV-2: A Chinese Lab Leak?
1.4: Vaccines, Herd Immunity, Transmissibility, and SARS-CoV-2 Variants
1.5: Vaccine Passports: A Bad Government Idea
1.6: COVID-19 Testing
1.7: Convalescent Plasma
1.8: Looking Back and Moving Forward: Will We Win?
Section 1: Medical Biochemistry and Genomics
Chapter 2: Role of Engineered Proteins as Therapeutic Formulations
2.1: Introduction
2.2: Protein Engineering Approaches
2.3: Protein Therapeutics
2.4: Protein-Based Scaffolds for Therapeutic Applications
2.5: Concluding Remarks
Chapter 3: How Physical and Chemical Information Predicts the Action of Molecules: A Historical Overview
3.1: A Definition for Pharmacology and Toxicology
3.2: Entities Do Not Act Unless Attached
3.3: The Language of Chemical Attachment
3.4: Types of Drugs and Their Actions
Chapter 4: Three-Dimensional Chromatin in Infectious Disease: A Role for Gene Regulation and Pathogenicity?
4.1: Introduction
4.2: Conclusions
Chapter 5: Aptamers, the Nucleic Acid Antibodies, in Cancer Therapy
5.1: Introduction
5.2: General Properties of Aptamers
5.3: Advantages and Limitations of Aptamers
5.4: Principle and Procedure of SELEX
5.5: Aptamers in Cancer Therapy
5.6: Cancer Therapy Aptamers in Clinical Trials
5.7: Conclusions
Chapter 6: Identifying Genetic Markers Associated with Susceptibility to Cardiovascular Diseases. 6.1: Methods
6.2: Diet and CVD Risk
6.3: Inherited Genetic Susceptibility
6.4: Pharmacogenetics and Future Potential
6.5: Conclusion
6.6: Future Perspective
Chapter 7: Production and Application of Multicistronic Constructs for Various Human Disease Therapies
7.1: Introduction
7.2: IRES
7.3: Self-Cleaving 2A Peptides
7.4: Multicistronic Vectors for Neurodegenerative Disease Therapy
7.5: Multicistronic Vectors for Metabolic Disease Therapy
7.6: Multicistronic Vectors for the Treatment of Autoimmune Diseases
7.7: Multicistronic Vectors for Cardiovascular Disease Therapy
7.8: Multicistronic Vectors for Cancer Therapy
7.9: Multicistronic Vectors for the Prevention of Viral and Bacterial Infections
7.10: Conclusions and Future Perspectives
Chapter 8: The Nuclear Lamina: Protein Accumulation and Disease
8.1: Introduction
8.2: Basic Structure and Function of the Nuclear Lamina
8.3: Hutchinson-Gilford Progeria Syndrome: A Protein Accumulation Disease of the Nuclear Lamina?
8.4: Lamina-Associated Protein Accumulation in Neurodegenerative Disease
8.5: Mechanisms of Protein Clearance from the Lamina
8.6: Autophagy and Nucleophagy-Mediated Clearance of Lamina Proteins
8.7: Mechanisms Marking Proteins for Removal from the Lamina
8.8: Promoting Lamina Protein Clearance
8.9: Concluding Remarks
Chapter 9: The Importance of Protein Post-Translational Modifications in the Pathogenesis and Progression of Neurodegenerative Diseases
9.1: Introduction
9.2: Methods
9.3: Results
9.4: Discussion
Chapter 10: DNA Damage/Repair Management in Cancers
10.1: Introduction
10.2: Types of DNA Damage
10.3: DNA Damage Response
10.4: Components of the DNA Damage Response
10.5: DDR and Disease Treatment
10.6: DNA Repair Pathways. 10.7: Cell Cycle as a Checkpoint in DNA Damage
10.8: Effects of Chemotherapy or Radiation in Cancer Treatments
10.9: Potential Biomarkers of Chromosomal Abnormalities
10.10: Clonal Evolution in Cancer
10.11: Conclusions
Chapter 11: Advancing Clinical Cohort Selection with Genomics Analysis on a Distributed Platform
11.1: Introduction
11.2: Materials and Methods
11.3: Results
11.4: Discussion
11.5: Conclusion
Chapter 12: Pharmacogenomics of Tamoxifen
12.1: What Is Tamoxifen?
12.2: Why Is Pharmacogenomics of Tamoxifen Important?
12.3: The Controversy in the Tamoxifen-CYP2D6 Study
12.4: Future Direction of Tamoxifen Pharmacogenomics
Chapter 13: Nanocrystals: The Universal Formulation Principle to Improve the Bioactivity of Poorly Soluble Actives
13.1: Introduction
13.2: First Generation of Drug Nanocrystals
13.3: SmartCrystals: Advantages of the Second Generation
13.4: Conclusion and Perspectives
Chapter 14: Cellular Mechanisms of Human Atherogenesis: Focus on Chronification of Inflammation and Mitochondrial Mutations
14.1: Introduction
14.2: Cellular Mechanisms of Atherogenesis
14.3: Variants of the Nuclear Genome Associated with Atherosclerosis
14.4: Variants of Mitochondrial Genome Associated with Atherosclerosis
14.5: Role of Mitochondrial Mutations in Cellular Mechanism of Atherosclerosis
Chronification of Inflammtion
14.6: Conclusions
Chapter 15: Vitamin D Pathway and the Pathogenesis of Inflammatory Bowel Disease
15.1: Introduction
15.2: Results
15.3: Discussion
15.4: Materials and Methods
Chapter 16: The Structural Ensemble of the Conjugative F-like T4SS
16.1: Introduction
16.2: Regulation of Bacterial Conjugation
16.3: Structures Involved in Pilin Processing, Pilus Extension, and Retraction. 16.4: Mating Pair Stabilization Proteins and the Dynamics of Their Structural Ensemble
16.5: The Structures of Conjugative DNA Transfer Proteins
16.6: Surface and Entry Exclusion Proteins
16.7: Conclusions
Chapter 17: Polygenic Risk-Tailored Screening for Prostate Cancer: A Benefit-Harm and Cost-Effectiveness Modelling Study
17.1: Introduction
17.2: Methods
17.3: Results
17.4: Discussion
17.5: Conclusion
Chapter 18: Apoptotic Bodies: Particular Extracellular Vesicles Involved in Intercellular Communication
18.1: Introduction
18.2: Apoptosis
18.3: Extracellular Vesicles, Other than Apoptotic Bodies
18.4: Apoptotic Bodies
18.5: Conclusions
Section 2: Human Physiology and Pathology
Chapter 19: Circulating Tumor Cells and Personalized Medicine
19.1: Metastasis and Circulating Tumor Cells
19.2: Enrichment and Detection of CTCs
19.3: Clinical Implications of CTC Detection and Enumeration
19.4: Molecular Characterization of CTC and Personalized Medicine
19.5: Summary
Chapter 20: Pathology in the Era of Personalized Medicine
20.1: Why Is the Role of Pathologists in Personalized Medicine Important?
20.2: Practical Guidance for Molecular Pathology
20.3: Next-Generation Sequencing and the Pathologist
20.4: Conclusions
Chapter 21: Speech Intelligibility during Clinical and Low Frequency
21.1: Introduction
21.2: Methods
21.3: Results
21.4: Discussion
Chapter 22: Physiological Renormalization Using Systems Therapeutics
Chapter 23: Pathology Is Always Around Us: Apophenia in Pathology, a Remarkable Unreported Phenomenon
Chapter 24: The Secrets of the Mediterranean Diet. Does [Only] Olive Oil Matter?
24.1: Introduction
24.2: Definition and Composition of Mediterranean Diet
24.3: Mediterranean Diet and Diet Diversity. 24.4: Mediterranean Diet Contribution to Immunomodulation
24.5: Summary
Chapter 25: Relationship between Diet, Microbiota, and Healthy Aging
25.1: Introduction
25.2: Interplay between Aging and Microbiota
25.3: The Influence of Nutrition on the Microbiota and Aging
25.4: Conclusions
Chapter 26: Does Low-Density Lipoprotein Cholesterol Induce Inflammation? If So, Does It Mater? Current Insights and Future Perspectives for Novel Therapies
26.1: Background
26.2: Cross-Talk between Dyslipidemia and Immunity
26.3: Inflammatory Biomarkers and Atherosclerosis
26.4: Lipid-Lowering Treatment and Anti-Inflammation: Is There a Causal Relationship?
26.5: Inflammation as a Novel Therapeutic Target for Atherosclerotic CV Disease: Insights from Recent Clinical Trials
26.6: (Cholesterol-Induced) Inflammation, Diseases Other Than Atherosclerosis, and Effects of Cholesterol Lowering by Statins
26.7: Residual Inflammatory Risk versus Residual Cholesterol Risk: No More Coin Flipping
26.8: Discussion
26.9: Conclusions
Chapter 27: Role of Biomarkers in Clinical Development of Cancer Therapies
27.1: Introduction
27.2: A Few Definitions and General Concepts
27.3: Role of Biomarkers in the Different Stages of Drug Development
27.4: Conclusions and Future Directions
Chapter 28: In Sickness and Health: Effects of Gut Microbial Metabolites on Human Physiology
28.1: The Impact of Gut Bacterial Metabolites on Host Physiology
28.2: Metabolism of Drugs and Other Xenobiotics by Gut Microbes
28.3: A Way Forward in the Search for Beter Therapeutics
Chapter 29: Current Methodologies Utilized in the Conduct of Randomized Clinical Trials
29.1: Utilization of Control
29.2: Placebo Control
29.3: Sham Procedures
29.4: Randomization
29.5: Methods of Randomization
29.6: Conclusion and Future Perspective
Chapter 30: The Prion-Like Phenomenon in Alzheimer's Disease: Evidence of Pathology Transmission in Humans.

Summary: This book reviews recent advances regarding the biochemical and biophysical properties of membrane proteins and their applications in biomedicine. Divided into two thematic parts, this second volume addresses proteins' formation, signaling and malfunctions. It covers a number of important membrane proteins including receptors, cell adhesion molecules, single-transmembrane proteins and viral membrane proteins, and discusses their structures, functions, related diseases, and roles in drug discovery in detail. In turn, the book elucidates the lifecycle of membrane proteins, including their synthesis and facilitated folding process, as well as QC procedures for their production. Additional topics include fundamental concepts, the latest findings, and critical puzzles yet to be solved. Given its scope, the book will appeal to a broad readership in the field of membrane structural and functional biology. Junior scientists can use it as an introduction to the field, while advanced scientists will find a broader view of the field beyond their area of specialization.

Contents:
Lipid Homeostasis on Cell Membrane
A Historical Perspective of G Protein-Coupled Receptor Structural Biology
Membrane Proteins as Targets for Biological Drugs
Cell Adhesion Molecules
The Biosynthesis and Folding of Oily Peptide Chains
Mechanism of Quality Control of Nascent Membrane Proteins.

Summary: The book summarizes advances in biochemical and biophysical property of membrane proteins as well as their applications in biomedicine. It is organised into 2 themed parts. The first volume focuses on mass processing and transportation and provides deep and comprehensive information on specific groups of membrane proteins including channels and transporters, nuclear and cytoplasmic membrane proteins, and membrane embedded enzymes. Their structures, functions, related diseases as well as their roles in drug discovery are fully discussed. Interesting topics cover fundamental concepts, latest progress and critical puzzles yet to be solved. This work will appeal to a wide readership within the membrane structural and functional biology field. Junior scientists could use it to fast track into the field. Advanced scientists will find it helpful to gain a broader view of the field beyond their area of specialization.

Contents:
Chapter 1: Membrane As the Barrier of Life
Chapter 2: Ion Channels
Chapter 3: Membrane Asymmetry and Phospholipid Translocases in Eukaryotic Cells
Chapter 4: Membrane Phospholipid Biosynthesis in Bacteria
Chapter 5: Transport and Communication Across the Nuclear Envelope
Chapter 6: Structural and Functional Properties of Viral Membrane Proteins.

Summary: This book serves as a concise text on nail diseases and disorders, offering the most up to date information available from internationally recognized speakers and authors. This comprehensive guide examines a multitude of nail disease types manifestations, treatments, and complications. Chapters delve into specific disorders such as yellow nail syndrome, psoriasis, lichen planus, and brittle nails. Notable treatments covered include advances in MRI, anti-neoplastic drugs and ultrasound imaging. The book also features discussions on unique topics, such as the convergence of orthopedics and onychology in nail disease treatment, as well as treatment complications faced by distinct demographics. Going beyond basics and diving right into the heart of various diseases and disorders, Advances in Nail Disease and Management will serve to aid experienced dermatologists looking for advanced expertise information.

Contents:
Chapter 1: Yellow Nail Syndrome
Chapter 2: Is Peri-ungual Vitiligo an Intractable Localization?
Chapter 3: Digital Myxoid Cysts: Ganglia of the Distal Interphalangeal Joint
Chapter 4: Advances in MRI of Glomus Tumors of the Fingertips
Chapter 5: Trachyonychia
Chapter 6: In vivo and ex vivo Confocal Microscopy for Nail Diseases
Chapter 7: Innovative Gene Therapies in Nail Disorders
Chapter 8: Toenails
Where Orthopedics and Onychologists Meet.-Chapter 9: Recent Advances in Nails in Systemic Disease
Chapter 10: Brittle Nails
Chapter 11: The Nail Involvement in Leprosy and Sporotrichosis.-Chapter 12: Latest Research in Nail Psoriasis
Chapter 13: Nail Lichen Planus.-Chapter 14: What's New in Pediatric Nail Disorders?
Chapter 15: Nail Changes with Targeted Anti-Neoplastic Drugs
Chapter 16: Optical Coherence Tomography in Nail Research and Diagnosis
Chapter 17: Drug-Induced Nail Changes
Chapter 18: Current Applications and Advances in Nail Ultrasound Imaging
Chapter 19: Onychomycosis: Usefulness of Histomycology.

Contents:
1. Nanomedicine for delivery of therapeutic molecules
2. Nanoparticles as nucleic acid delivery vectors
3. Methods for charactericzation of nanoparticles
4. Nanoparticles for DNA delivery
5. Nanoparticles for siRNA-mediated gene silencing
6. Nanoparticles for locked nucleic acid delivery
7. Nanoparticles for ribozymes delivery
8. Nanoparticles for DNAzymes delivery
9. Pharmacokinetics and biodistribution of the nanoparticles
10. Nanotoxicology: evaluation of toxicity potential of nanoparticles
11. Regulatory aspects of nanoparticulate mediated nucleic acid delivery systems
12. Clinical studies and future prospects
Index.

Summary: "This book aims to provide a comprehensive overview of advances in neurolaryngology, e.g., in diagnostic approaches and techniques, and therapeutic interventions, from experts in various medical specialties. It presents the increasingly common multidisciplinary approach to patients' problems, with cross discipline interaction involving otolaryngologists, neurologists, radiologists, respiratory physicians, neurophysiologists, and speech pathologists"-- Provided by publisher.

Summary: This book comprises proceedings from the Third International Conference on Advances in Nutrition and Cancer, held in Naples in May 2012. This highly multidisciplinary meeting analyzed nutrition and cancer from different perspectives and on the basis of distinct and up-to-date experimental approaches. Knowledge on the relation between lifestyle, diet, and cancer is explored in a number of contributions, and the role of dietary intervention in cancer patients is discussed. Issues of vital interest to the research community, such as epidemiological and experimental oncology (genetics, epigenetics, and the mechanisms of action of natural compounds in the diet), receive detailed consideration. A further key topic is the emerging molecular technologies (the -omics) that can cast light on the interplay between nutrition and human malignancies. Chapters take the form of reviews that include sections presenting expert opinions. Advances in Nutrition and Cancer will be an invaluable source of topical information for all researchers and clinicians with an interest in this field.

Contents:
Part I: Lifestyle, Diet, and Cancer
The Role of Metabolic Carcinogenesis in Cancer Causation and Prevention: Evidence from the European Prospective Investigation into Cancer and Nutrition
Obesity, Energy Balance, and Cancer: A Mechanistic Perspective
Fruits and Vegetables: Updating the Epidemiologic Evidence for the WCRF/AICR Lifestyle Recommendations for Cancer Prevention
The Diet as a Cause of Human Prostate Cancer
Mediterranean Dietary Pattern and Chronic Diseases
Dietary Salt Intake and Risk of Gastric Cancer
Alcoholic Beverages and Carbonated Soft Drinks: Consumption and Gastrointestinal Cancer Risks
Part II: Natural Dietary Molecules
Anti-Inflammatory and Anticancer Drugs from Nature
Selenium and Cancer: A Story that Should not be Forgotten-Insights from Genomics
Resveratrol: From Basic Studies to Bedside
Quercetin: A Pleiotropic Kinase Inhibitor Against Cancer
Sulforaphane as a Promising Molecule for Fighting Cancer
Part III: Genetics and Epigenetics
Functions, Aberrations, and Advances for Chromatin Modulation in Cancer
Epigenetics and Epidemiology: Models of Study and Examples
Dietary Epigenetics in Cancer and Aging
Breast Cancer and the Importance of Early Life Nutrition
Part IV: Olive Oil in Cancer Prevention
Olive Oil and Other Dietary Lipids in Breast Cancer
A Holistic Approach to Study the Effects of Natural Antioxidants on Inflammation and Liver Cancer
Extra Virgin Olive Oil: From Composition to "Molecular Gastronomy"
Part V: Life Style Prevention of Cancer
Life Style Prevention of Cancer Recurrence: The Yin and the Yang
Part VI: Emerging Breakthroughs
New Perspective for an Old Antidiabetic Drug: Metformin as Anticancer Agent
Gut Microbes, Diet, and Cancer
Inflammatory Angiogenesis and the Tumor Microenvironment as Targets for Cancer Therapy and Prevention
Nutriomes and Personalised Nutrition for DNA Damage Prevention, Telomere Integrity Maintenance and Cancer Growth Control
Novel Approaches in Melanoma Prevention and Therapy
Concluding Remarks.

Summary: Serving as a practical guide to the ocular imaging modalities that are currently available to eye care providers for the care of glaucoma patients, this book provides information on advances in ocular imaging and their applications in the diagnosis and management of glaucoma. Each chapter introduces the imaging modality, highlight its strengths and weaknesses for clinical care, and discuss its integration into the clinical examination and decision-making process. The chapters also provide an in-depth description of the interpretation of images from each imaging modality. When appropriate, the chapters will summarize past and ongoing research and propose future research directions and clinical applications. This title will appeal to ophthalmologists and optometrists at all levels, from trainees to experienced clinicians looking to learn new and important information.

Summary: This book summarizes the latest advances in pain research. All the chapters were contributed by speakers from Asian Pain Symposium (APS) on Acute and Chronic Pain, which was held in Taipei in 2017. Founded in Kyoto, Japan in 2000, the APS serves as a platform for scientists to present recent findings in pain research and discuss research orientation in this field. APS 2017 focused on novel strategies for pain treatment. Written by experts from various disciplines, from molecular to functional, and from basic to clinic studies, this book is composed of 18 review articles on the physiology and pathology of pain in these research fields. Specific topics include circuitry, neurotransmitter, physiology, behavior, neuropathology, pharmacology, and the treatments for neuropathic pain disorders. The book is a valuable resource for researchers and graduate students in pain medicine and neuroscience.

Contents:
Molecular mechanisms of the sense of touch: an overview of mechanical transduction and transmission in merkel discs of whisker hair follicles and some clinical perspectives / Jianguo G. Gu
Trp channels in nociception and pathological pain / Chen-Yu Hung, Chun-Hsiang Tan
Involvement of TRPV1-ANO1 interactions in pain-enhancing mechanisms / Y. Takayama, Makoto Tominaga
Roles of ASICs in nociception and proprioception / Cheng-Han Lee, Chih-Cheng Chen
Tackling pain associated with rheumatoid arthritis: proton-sensing receptors / Wei-Hsin Sun, Shih-Ping Dai
Advances in experimental medicine and biology: intrafascicular local anesthetic injection damages peripheral nerve-induced neuropathic pain / Kuang-Yi Tseng, Hung-Chen Wang, Lin-Li Chang, Kuang-I Cheng
Microglia in the CNS and neuropathic pain / Makoto Tsuda
Descending noradrenergic inhibition: an important mechanism of gabapentin analgesia in neuropathic pain / Ken-ichiro Hayashida, James C. Eisenach
Chronic neuropathic pain protects the heart from ischemia-reperfusion injury / Yi-Fen Cheng, Chien-Chang Chen
Knowing the neuronal mechanism of spontaneous pain to treat chronic pain in the future / Xiang-Yao Li, Jing-Hua Wang, Cheng Wu
Role of neuroinflammation in opioid tolerance: translational evidence from human-to-rodent studies / Chih-Peng Lin, Dai-Hua Lu
Neural mechanisms of offset analgesia / Jiro Kurata
Cortical ltp: a synaptic model for chronic pain / Min Zhuo
Pain-associated neural plasticity in the parabrachial to central amygdala circuit / Fusao Kato, Yae K. Sugimura, Yukari Takahashi
Electrophysiological signature of pain / Zi-Fang Zhao, You Wan
Neuroimaging studies of primary dysmenorrhea / Intan Low, Shyh-Yuh Wei, Pin-Shiuan Lee, Wei-Chi Li, Lin-Chien Lee, Jen-Chuen Hsieh [and others]
Brain reward circuit and pain / Moe Watanabe, Minoru Narita
Involvement of P₂X₇ receptors and BDNF in the pathogenesis of central poststroke pain / Yung-Hui Kuan, Hsi-Chien Shih, Bai-Chuang Shyu
Melatonin: a new-generation therapy for reducing chronic pain and improving sleep disorder-related pain / Tavleen Kaur, Bai-Chuang Shyu
Central poststroke pain, comorbidity, and associated symptoms in animal and human models / Bai-Chuang Shyu, Andrew Chih Wei Huang.

Summary: This book describes practical, contemporary, and evidence-based surgical approaches for the treatment of diseases and conditions affecting the periodontium, including advanced forms of periodontal disease, gingival recession, and complex cases requiring interdisciplinary management. The book opens by identifying key considerations in periodontal surgery, for example with regard to diagnosis and prognosis, and by presenting decision trees that will be useful in daily practice. Cutting-edge resection and regeneration techniques for the treatment of periodontitis and mucogingival surgical procedures for the management of soft tissue deficiencies are then described and illustrated in detail, highlighting important tips and tricks as well as potential difficulties and complications. The final part of the book is devoted to interdisciplinary care, which is of key importance when periodontal surgery is indicated in the management of cases requiring orthodontic, endodontic, and restorative therapy. Advances in Periodontal Surgery will be of value for practitioners at all levels of experience as well as for students entering the field.

Contents:
Part 1 Key Consideration of Periodontal Surgery
The Miller McEntire Periodontal Prognostic Index
Decision Trees in periodontal surgery: resective versus regenerative periodontal surgery
Part 2 Resective Techniques of Periodontal Surgery
Periodontal flap designs for access and osseous surgery
Biologic shaping
Lasers in periodontal surgery
Part 3 Regenerative Techniques of Periodontal Surgery
Videoscope assisted minimally invasive surgery (VMIS) for bone regeneration
Regeneration of intrabony defects utilizing stem cells allograft
Management of furcation defects
Part 4 Mucogingival and Periodontal Plastic Surgery
Coronally positioned flaps and tunneling
Rationale for gingival tissue augmentation and vestibuloplasty around teeth and dental implants
Mucogingival and periodontal plastic surgery: lateral sliding flaps
Part 5 Interdisciplinary Management of Periodontal Surgery
Crown lengthening and prosthetic considerations
The adjunctive relationship between orthodontics and periodontics
Surgically facilitated orthodontic therapy
Management of endodontic-periodontic lesions.

Summary: This book is a guide to new and emerging PET technology, instrumentation, and its place in clinical practice. PET technology is currently moving from the conventional photomultiplier tube (PMT) detector based PET to the new generation, solid state light sensor detector. This is a technological leap and holds significant implications for the use of PET imaging. This book introduces and describes the emerging and new generation of PET instrumentations and technologies across manufactures, focusing on solid-state PET detector designs, system characteristics, and clinical practices as well as future advanced Time-of-Flight (TOF) PET technologies. Organized into three sections, the basics of PET imaging; solid state digital PET instrumentation, technology, and clinical practice; and a look to the future of PET imaging, chapters present a full picture of PET imaging, where we are and where we will be. Nuclear medicine physicians, physicists, and technologists can use this book to better understand future PET systems, novel PET technologies, and potential game changes of clinical PET practice.

Summary: Biotechnology refers to the use or manipulation of an organism or parts of an organism. While the early applications were certainly simpler (though still relevant), modern plant biotechnology is primarily associated with molecular biology, cloning and genetic engineering. Over the last 50 years, several key discoveries have revolutionized the biological sciences and enabled the rapid growth of the biotechnology industry. This book gathers handpicked articles presented by national and international scientists at the International Conference on Biotechnology and Biological Sciences, BIOSPECTRUM 2017. It highlights the works of researchers and students in India and abroad on plant biotechnology and its applications in addressing various agricultural and food production-related issues. The respective papers explore a range of advances in plant biotechnology, e.g.: the cytotoxic potential of Moringaoleifera lam; the use of the entomo-pathogenic fungi Cordyceps sp. as unique and valuable sources of bioactive compounds; and strain improvement strategies for Cordyceps sp. In addition, they discuss the use of low-cost blue green algal biofertilizer comprising four blue green algal strains in rice fields; and the use of lignocellulosic materials as potential renewable energy resources for the production of fuels. This book will be extremely useful for researchers and students of biotechnology and plant science, providing an essential update on the latest findings and trends.

Contents:
Introduction
Chapter 1: Dilute Acid Pretreatment Efficiency on Various Solid Loadings and Effect of Different Neutralizing Agents on Xylulosic Ethanol Production
Chapter 2: Effect of BGA Biofertilizers Using Different Carrier Materials on Rice Crop
Chapter 3: Identification of Differentially Expressed Terminal Heat Stress Associated Proteins in Developing Grains in Wheat (Triticum Aestivum L.)
Chapter 4: The genetic toxicity potential of heavy metals (Zn, Cu) on Vigna radiata, Triticum aestivum and Cicer arietinum
Chapter 5: Production, Optimization, and Charaterization of Siderophore by Pseudomonas Aeruginosa (C3) Isolated From Rhizospheric Soil
Chapter 6: Development of Marker in the Soft Gold Mushroom Cordyceps Sp. For Strain Improvement
Chapter 7: Optimization of Microwave Assisted Pretreatment of Rice Straw with Fecl3 in Combination with H3po4 for Improving Enzymatic Hydrolysis
Chapter 8: Profiling Indolic Auxins Produced by the Strains of Aspergillus Using Novel HPTLC Technique
Chapter 9: Comparative Analysis of Cytotoxic Potential of Crude Extracts and Fractionated Isolates from Moringa Oleifera Lam
Chapter 10: Hydroxy Fatty Acid from Camelina Sativa Seed Oil for Industrial Application
Chapter 11: Comparison of Different Planting Methods to Determine the Precision of Phenotyping Wheat in Field Experiments
Chapter 12: Effect of extraction temperature and different carrier agents on the physicochemical and antioxidant properties of spray dried Murraya koenigii (Linn.) leaf extract
Chapter 13: Isolation and characterization of microbial Asparaginase to mitigate Acrylamide formation in food
Chapter 14: Small Colony Variant Selection, Biofilm Induction and Interspecies Interactions of Ocular Clinical Pseudomonas aeruginosa
Chapter 15: Comparative analysis of phytochemicals of healthy and symptomatic Clerodendrum inerme
Chapter 16: Synthesis of Silver Nanoparticle of Aqueous extract of Allium Fistulosum and Its Efficiency against Bacterial Contaminants from Industrial waste water and its Photocatalytic potential
Chapter 16: Exploration of biocontrol and growth promoting activity of bacterial strains isolated from the sugarcane crop.

Summary: This book examines the development of innovative modern methodologies towards augmenting conventional plant breeding for the production of new crop varieties, under the increasingly limiting environmental and cultivation factors, to achieve sustainable agricultural production and enhanced food security. Two volumes of Advances in Plant Breeding Strategies were published in 2015 and 2016, respectively; Volume 1: Breeding, Biotechnology and Molecular Tools and Volume 2: Agronomic, Abiotic and Biotic Stress Traits. This is Volume 3: Fruits, which is focused on advances in breeding strategies for the improvement of individual fruit crops. It consists of 23 chapters grouped into three parts, according to distribution classification of fruit trees: Part I, Temperate Fruits, Part II, Subtropical Fruits, and Part III, Tropical Fruits. Each chapter comprehensively reviews the modern literature on the subject and reflects the authors' own experience.

Contents:
Preface.- List of Contributors.- Part I. Temperate Fruits.-
1. Apple (Malus spp.) Breeding: Present and Future; S. Pereira-Lorenzo et al.-
2. Cherry Breeding: Sweet Cherry (Prunus avium L.) and Sour Cherry (Prunus cerasus L.); L. Dondini et al.-
3. Mulberry (Morus spp.) Breeding for Higher Fruit Production; K. Vijayan et al.-
4. Pear (Pyrus spp.) Breeding; G.J. da Silva et al.-
5. Plum (Prunus spp.) Breeding; T. Milošević, N. Milošević.-
6. Quince (Cydonia oblonga Mill.) Breeding; S. Kafkas et al.- Part II. Subtropical Fruits.-
8. Cactus Pear (Opuntia spp.) Breeding; M.A. Mazri.-
9. Improvement of Fig (Ficus carica L.) by Conventional Breeding and Biotechnology; F. Aljane et al.-
10. Kiwifruit (Actinidia spp.) Breeding; Z. Hanley.-
11. Citrus Genetics and Breeding; J. Cuenca et al.-
12. Advanced Innovative Tools in Lemon (Citrus limon L.) Breeding; I. Polat.-
13. Mandarin (Citrus reticulate Blanco) Breeding; M. Usman, B. Fatima.-
14. Strategies for Olive (Olea eurpaea L.) Breeding: Cultivated Genetic Resources and Crossbreeding; L. Rallo et al.-
15. Pomegranate (Punica granatum L.) Breeding; D. Holland, I. Bar-Ya'akov.- Part III. Tropical Fruits.-
16. Genetics and Breeding of Fruit Crops in the Annonaceae Family: Annona spp. and Asimina spp.; J. Lora et al.-
17. Breeding of Coconut (Cocos nucifera L.): The Tree of Life; Y. Yang et al.-
18. Advances in Date Palm (Phoenix dactylifera L.) Breeding; J.M. Al-Khayri et al.-
19. Breeding of Garcinia spp.; H.N. Murthy et al.-
20. Mango (Mangifera indica L.) Breeding; I.S.E. Bally, N.L. Dillon.-
21. Genetic Improvement of Papaya (Carica papaya L.); F. Karambu Rimberia et al.-
22. Passion Fruit (Passiflora spp.) Breeding; C.B. Moreno Cerquiera-Silva et al.-
23. Genetics and Breeding of Fruit Crops in the Sapindaceae Family: Lychee (Litchi chinensis Sonn.) and Longan (Dimocarpus longan Lour.); J. Lora et al.- Index.

Summary: Plant breeders and geneticists are under constant pressure to sustain and expand food production by using innovative breeding strategies and introducing minor crops, which are well adapted to marginal lands, provide a source of nutrition, and have abiotic and biotic stress tolerance, to feed an ever-increasing human population. The basic concept of this book is to examine the use of innovative methods augmenting traditional plant breeding towards the improvement and development of new crop varieties, under the increasingly limiting environmental and cultivation factors, to achieve sustainable agricultural production and enhanced food security. In addition to developing improved crops for innovative industrial products such as pharmaceuticals and food additives, biofuels, oils and textiles. Three volumes of this book series were published in 2015, 2016 and 2018, respectively: Volume 1. Breeding, Biotechnology and Molecular Tools; Volume 2. Agronomic, Abiotic and Biotic Stress Traits and Volume 3. Fruits. In 2019, the following four volumes are concurrently being published: Volume 4. Nut and Beverage Crops, Volume 5. Cereals, Volume 6. Industrial and Food Crops and Volume 7. Legumes. This Volume 4, subtitled Nut and Beverage Crops, focuses on advances in breeding strategies using both traditional and modern approaches for the improvement of individual plantation crops. Included in Part I, eleven important nut species recognized for their economical and nutritional importance including Almond, Argan, Brazil nut, Cashew nut, Chestnut, Hazelnut, Macadamia, Peanut, Pine nut, Pistachio and Walnut. Part II covers two popular beverage species, coffee and tea. Chapters are written by 53 internationally reputable scientists from 13 countries and subjected to a review process to assure quality presentation and scientific accuracy. Each chapter begins with an introduction covering related backgrounds and provides in-depth discussion of the subject supported with 108 high quality color figures, and relevant data in 55 tables. The chapter concludes with recommendations for future research directions, appendixes of genetic resources and concerned research institutes and a comprehensive list of pertinent references to facilitate further reading. This book series is a valuable resource for advanced students, researchers, scientists, commercial producers and seed companies as well as consultants and policymakers interested in agriculture, particularly in modern breeding technologies.

Contents:
Preface.- About the Editors.- Contributors.- Part I. Nut Crops.-
1. Almond [Prunus dulcis (Miller) D.A. Webb] Breeding; Pedro J. Martínez-García et al.-
2. Genetic Diversity and Breeding of Argan Tree (Argania spinosa L. Skeels); Naima Ait Aabd et al.-
3. Brazil Nut (Bertholletia excels Bonpl.) Breeding; Aisy Botega Baldoni et al.-
4. Cashew Nut (Anacardium occidentale L.) Breeding Strategies; Suvalaxmi Palei et al.-
5. Chestnut (Castanea spp. Miller) Breeding; J. Hill Craddock, M. Taylor Perkins.-
6. Hazelnut (Corylus spp.) Breeding; Roberto Botta et al.-
7. Macadamia (Macadamia spp.) Breeding; Bruce L. Topp et al.-
8. Peanut (Arachis hypogaea L.) Breeding; Saikat Gantait et al.-
9. Advances in Edible Pine Nut Trees (Pinus spp.) Breeding Strategies; Hanguo Zhang, Zhen Zhang.-
10. Pistachio (Pistacia spp.) Breeding; Abdollatif Sheikhi et al.-
11. Advances in Walnut (Juglans regia L.) Breeding Strategies; Kourosh Vahdati et al.- Part II. Beverage Crops.-
12. Genetic Resources and Breeding of Coffee (Coffeea spp.); Manoj K. Mishra.-
13. Advances in Tea [Camellia sinensis (L.) O. Kuntze] Breeding; Mahasen A.B. Ranatunga.- Index.

Summary: Plant breeders and geneticists are under constant pressure to sustain and expand food production by using innovative breeding strategies and introducing minor crops, which are well adapted to marginal lands, provide a source of nutrition, and have abiotic and biotic stress tolerance, to feed an ever-increasing human population. The basic concept of this book is to examine the use of innovative methods augmenting traditional plant breeding towards the improvement and development of new crop varieties, under the increasingly limiting environmental and cultivation factors, to achieve sustainable agricultural production and enhanced food security. In addition to developing improved crops for innovative industrial products such as pharmaceuticals and food additives, biofuels, oils and textiles. Three volumes of this book series were published in 2015, 2016 and 2018, respectively: Volume 1. Breeding, Biotechnology and Molecular Tools; Volume 2. Agronomic, Abiotic and Biotic Stress Traits and Volume 3. Fruits. In 2019, the following four volumes are concurrently being published: Volume 4. Nut and Beverage Crops, Volume 5. Cereals, Volume 6. Industrial and Food Crops and Volume 7. Legumes. This Volume 5, subtitled Cereals, focuses on advances in breeding strategies using both traditional and modern approaches for the improvement of individual crops. It addresses important staple food crops including barley, fonio, finger millet, foxtail millet, pearl millet, proso millet, quinoa, rice, rye, tef, triticale and spelt wheat. Chapters are written by 60 internationally reputable scientists from 14 countries and subjected to a review process to assure quality presentation and scientific accuracy. Each chapter begins with an introduction covering related backgrounds and provides in-depth discussion of the subject supported with 138 high quality color figures, and relevant data in 78 tables. The chapter concludes with recommendations for future research directions, appendixes of ge netic resources and concerned research institutes and a comprehensive list of pertinent references to facilitate further reading. This book series is a valuable resource for advanced students, researchers, scientists, commercial producers and seed companies as well as consultants and policymakers interested in agriculture, particularly in modern breeding technologies.

Contents:
Preface
About the Editors
Contributors
1. Barley (Hordeum vulgare L.) Breeding; Essam Fathy El-Hashash, Karima Mohamed El-Absy
2. Fonio (Digitaria spp.) Breeding; Suleiman Dangana Abdul, Afam I.O. Jideani
3. Finger Millet (Eleusine coracana L. Gartn.) Breeding; Neelofar Mirza, Soma S. Marla
4. Foxtail Millet (Setaria italica L.): Potential of Smaller Millet for Future Breeding; Mangesh Pradip Moharil et al
5. Breeding of Pearl Millet (Pennisetum glaucum (L.) R. Br.); Ashita Bisht et al
6. Proso Millet (Panicum miliaceum L.) Breeding: Progress, Challenges and Opportunities; Dipak K. Santra et al
7. Quinoa (Chenopodium quinoa Willd.) Breeding; Luz Rayda Gomez-Pando et al
8. Molecular Breeding Strategies for Genetic Improvement in Rice (Oryza sativa L.); Ritu Mahajan, Nisha Kapoor
9. Hybrid Breeding in Rye (Secale cereale L.); Thomas Miedaner, Friedrich Laidig
10. Tef [Eragrostis tef (Zucc.) Trotter] Breeding; Solomon Chanyalew et al
11. Triticale (X Triticosecale Wittmack) Breeding; Mohamed Mergoum et al
12. CRISPR/Cas9 Genome Editing in Bread Wheat (Triticum aestivum L.) Genetic Improvement; Soleyman Dayani et al
13. Durum Wheat (Triticum turgidum ssp. durum) Breeding to Meet the Challenge of Climate Change; Pasquale De Vita, Francesca Taranto
14. Spelt Wheat [Triticum aestivum ssp. spelta (L.) Thell.] Breeding via In Vitro Androgenesis for Special Food Quality Parameters; János Pauk et al
15. Recent Advances in Wheat (Triticum spp.) Breeding; Amira M.I. Mourad et al
Index.

Summary: Plant breeders and geneticists are under constant pressure to sustain and expand food production by using innovative breeding strategies and introducing minor crops, which are well adapted to marginal lands, provide a source of nutrition, and have abiotic and biotic stress tolerance, to feed an ever-increasing human population. The basic concept of this book is to examine the use of innovative methods augmenting traditional plant breeding towards the improvement and development of new crop varieties, under the increasingly limiting environmental and cultivation factors, to achieve sustainable agricultural production and enhanced food security. In addition to developing improved crops for innovative industrial products such as pharmaceuticals and food additives, biofuels, oils and textiles. Three volumes of this book series were published in 2015, 2016 and 2018, respectively: Volume 1. Breeding, Biotechnology and Molecular Tools; Volume 2. Agronomic, Abiotic and Biotic Stress Traits and Volume 3. Fruits. In 2019, the following four volumes are concurrently being published: Volume 4. Nut and Beverage Crops, Volume 5. Cereals, Volume 6. Industrial and Food Crops and Volume 7. Legumes. This Vol 6, subtitled Industrial and Food Crops, consists of 2 parts. Included in Part I are 11 industrial plant species utilized as sources of raw materials for the production of industrial products including pulp and wood crops (acacia), fiber (cotton, jute and ramie), rubber (guayule and rubber tree), oil (jojoba and flax), biofuels and pharmaceutical (agave) and sugar source (sugarcane). Part II covers 7 food plants selected for their utilization in food industries for the production of chocolate (cacao), cooking oil (oil palm, safflower, sesame and sunflower) and natural flavors and aroma (saffron and vanilla). Chapters are written by 60 internationally reputable scientists from 14 countries and subjected to a review process to assure quality presentation and scientific accuracy. Eac h chapter begins with an introduction covering related backgrounds and provides in-depth discussion of the subject supported with 138 high quality color figures, and relevant data in 78 tables. The chapter concludes with recommendations for future research directions, appendixes of genetic resources and concerned research institutes and a comprehensive list of pertinent references to facilitate further reading. This book series is a valuable resource for advanced students, researchers, scientists, commercial producers and seed companies as well as consultants and policymakers interested in agriculture, particularly in modern breeding technologies.

Contents:
Intro; Preface; Contents; Editors and Contributors; Part I: Industrial Crops;
Chapter 1: Genetics and Breeding of Tropical Acacias for Forest Products: Acacia mangium, A. auriculiformis and A. crassicarpa; 1.1 Introduction; 1.2 Silviculture and Conventional Breeding; 1.2.1 Current Cultivation Practices; 1.2.2 Current Problems and Challenges; 1.2.3 Improvement Strategy; 1.2.4 Traditional Breeding Methodologies and Limitations; 1.2.5 Role of Biotechnology; 1.3 Germplasm Biodiversity and Conservation; 1.3.1 Germplasm Diversity; 1.3.2 Species Characterization and Phylogeny 1.3.3 Genetic Resources Conservation Approaches1.4 Hybridization; 1.5 Conclusion and Prospects; Appendices; Appendix I: Research Institutes Relevant to Acacias; Appendix II: Genetic Resources of Acacias; References;
Chapter 2: Cotton (Gossypium hirsutum L.) Breeding Strategies; 2.1 Introduction; 2.2 Cotton Sustainable Production; 2.3 Cotton Genetic Resources and Conservation; 2.3.1 Cytogenetics and Evolution; 2.3.2 World Cotton Germplasm Collections; 2.3.3 Utilization of Wild Germplasm; 2.3.4 Colored Cotton; 2.4 Traditional Cotton Breeding Programs; 2.5 Genomic Database; 2.6 Mutation Breeding 2.7 In Vitro Applications2.8 Transgenic Cotton; 2.9 Improvement of Cotton Against Abiotic Stresses; 2.10 Improvement of Cotton Against Biotic Stresses; 2.11 New Emerging Technologies; 2.12 Conclusions and Prospects; Appendices; Appendix I: Research Institutes Relevant to Cotton Breeding and Biotechnology; Appendix II: Cotton Genetic Resources; References;
Chapter 3: CRISPR/Cas9: A New Genome Editing Tool to Accelerate Cotton (Gossypium spp.) Breeding; 3.1 Introduction; 3.2 Different Versions of CRISPR/Cas Systems and Their Applications 3.3 Functional Genomics and Limitations in Cotton Breeding3.4 Difference Between Genome Editing and Classical Breeding of Cotton; 3.5 Layout Plan of CRISPR/Cas-Based Genome Editing; 3.5.1 Data Mining and Single Guide RNA (sgRNA) Designing for Target Sequence; 3.5.2 Choice of CRISPR/Cas System; 3.5.3 Delivering CRISPR/Cas Cassettes into Cotton Genome; 3.5.4 Manipulation of Targeted Mutagenesis Through In Vitro Regeneration and Screening of Transgenic Plants; 3.5.5 Detection and Confirmation of Successful Genome Modification 3.6 Potential Applications of CRISPR/Cas in the Post-Genomic Era of Cotton Breeding3.7 Multiplexed Gene Stacking Using CRISPR/Cas9; 3.8 Countering Off-targets During Genome Editing; 3.9 Production of Transgene-Free Cotton; 3.10 Genome Editing Bottlenecks in Polyploid Cotton; 3.11 Conclusions and Prospects; Appendix I: Some Research Institutes Relevant to Cotton Molecular Breeding; References;
Chapter 4: Jute (Corchorus spp.) Breeding; 4.1 Introduction; 4.2 Germplasm Conservation, Biodiversity and Utilization; 4.2.1 Germplasm Conservation; 4.2.2 Taxonomy and Germplasm Classification

Summary: Plant breeders and geneticists are under constant pressure to sustain and expand food production by using innovative breeding strategies and introducing minor crops, which are well adapted to marginal lands, provide a source of nutrition, and have abiotic and biotic stress tolerance, to feed an ever-increasing human population. The basic concept of this book is to examine the use of innovative methods augmenting traditional plant breeding towards the improvement and development of new crop varieties, under the increasingly limiting environmental and cultivation factors, to achieve sustainable agricultural production and enhanced food security. In addition to developing improved crops for innovative industrial products such as pharmaceuticals and food additives, biofuels, oils and textiles. Three volumes of this book series were published in 2015, 2016 and 2018, respectively: Volume 1. Breeding, Biotechnology and Molecular Tools; Volume 2. Agronomic, Abiotic and Biotic Stress Traits and Volume 3. Fruits. In 2019, the following four volumes are concurrently being published: Volume 4. Nut and Beverage Crops, Volume 5. Cereals, Volume 6. Industrial and Food Crops and Volume 7. Legumes. This Volume 7, subtitled Legumes, focuses on advances in breeding strategies using both traditional and modern approaches for the improvement of individual legume crops. Included in this volume are Adzuki bean, Black gram, Chickpea Cluster bean, Common bean, Cowpea, Faba bean, Hyacinth bean, Lentil, Mung bean, Pigeonpea and Soybean. Chapters are written by 57 internationally reputable scientists from 9 countries and subjected to a review process to assure quality presentation and scientific accuracy. Each chapter begins with an introduction covering related backgrounds and provides in-depth discussion of the subject supported with 81 high quality color figures, and relevant data in 47 tables. The chapter concludes with recommendations for future research directions, appendixes of genetic resources and concerned research institutes and a comprehensive list of pertinent references to facilitate further reading. This book series is a valuable resource for advanced students, researchers, scientists, commercial producers and seed companies as well as consultants and policymakers interested in agriculture, particularly in modern breeding technologies.

Contents:
Preface
About the Editors
Contributors
1. Adzuki Bean (Vigna angularis (Willd.) Ohwi & Ohashi) Breeding; Lixia Wang et al
2. Recent Advances in Breeding, Marker Assisted Selection and Genomics of Black Gram [Vigna mungo (L.) Hepper]; Farrukh Azeem et al
3. Chickpea (Cicer arietinum L.) Cytogenetics, Genetic Diversity and Breeding; Aamir Raina et al
4. Cluster Bean [Cyamopsis tetragonoloba (L.) Taub] Breeding; Aravind Kumar Jukanti et al
5. Common Bean (Phaseolus vulgaris L.) Breeding; Oswalt R. Jimenez
6. Cowpea [Vigna unguiculata (L.) Walp.] Breeding; Ousmane Boukar et al
7. Faba Bean (Vicia faba L.) Breeding; Xuxiao Zong et al
8. Hyacinth Bean (Lablab purpureus L. Sweet): Genetics, Breeding and Genomics; Panichayil V. Vaijayanthi et al
9. Lentil (Lens culinaris Medik.) Diversity, Cytogenetics and Breeding; Rafiul Amin Laskar et al
10. Mung Bean (Vigna radiate (L.) R. Wilczek) Breeding; Jungmin Ha, Suk-Ha Lee
11. Pigeonpea (Cajanus cajan L. Millsp.): An Ideal Crop for Sustainable Agriculture; Rachit K. Saxena et al
12. Soybean [Glycine max (L.) Merr.] Breeding: History, Improvement, Production and Future Opportunities; Edwin J. Anderson et al.

Summary: In the post-genomic era, several plant species have been sequenced and massive genomic information is now available which contributed to expand the development of novel technical strategies for the study of additional levels of biological information of plant species. This book focuses on the "omics" approaches together with systems analysis of several different plant species, which have revealed very interesting variations on the cellular responses at the protein, transcript and metabolite levels in response to changes environmental conditions. The volume covers recent technological advances in the area of "omics" and synthesizes recent findings of the field of plant "omics" and systems biology together along with techniques that can be applied for such studies.

Contents:
1. Introduction to plant omics and systems biology
2. Modern approaches for transcriptome analyses in plants
3. Plant proteomics and systems biology
4. Subcellular proteomics as a unified approach of experimental localizations and computed prediction data for Arabidopsis and crop plants
5. The contribution of metabolomics to systems biology: current applications bridging genotype and phenotype in plant science
6. Interactomes: Experimental and in silico approaches
7. Probabilistic graphical models applied to biological networks
8. Cataloging posttranslational modifications in plant histones
9. Current challenges in plant systems biology
10. Contribution of omics and systems biology to plant biotechnology.

Summary: The green revolution led to the development of improved varieties of crops, especially cereals, and since then, classical or molecular breeding has resulted in the creation of economically valuable species. Thanks to recent developments in genetic engineering, it has become possible to introduce genes from different sources, such as bacteria, fungi, viruses, mice and humans, to plants. This technology has made the scientific community aware of the critical role of transgenics, not only as a means of producing stress tolerant crops but also as a platform for the production of therapeutics through molecular farming. This book discusses the commercial applications of plant transgenic technologies, including the use of transgenic cell culture approachesto improve the production of metabolites and high-value therapeutics as well as transgenic plants in pest management. It also explores generation of novel vectors, protein production using chloroplast engineering and the latest developments in this area, such as genome editing in plants. Featuring general discussions and research papers by leading international experts, it is a valuable resource for scientists, teachers, students and industrialists working in the field.

Contents:
Chapter 1. Plant Tissue Culture and DNA Delivery Methods
Chapter 2. Cell Cultures and Hairy Roots as Platform for Production of High Value Metabolites: Current Approaches, Limitations and Future Prospects
Chapter 3. Integrating Bioinformatics and Omics tools for systems analysis of abiotic stress tolerance in Oryza sativa (L.)
Chapter 4. Green Biotechnology: A brief update on Plastid Genome Engineering
Chapter 5. New Generation Transformation Vectors
6 Recent Developments in Generation of Marker Free Transgenic Plants
Chapter 7. Applications of Genome Engineering/Editing Tools in Plants
Chapter 8. High Throughput Analytical Techniques to Screen Plant Transgenics
Chapter 9. Transgenic Technologies and their Potential Application in Horticultural Crop Improvement
Chapter 10. Commercial Application of Transgenic Plants in Virus Management
Chapter 11. Application of Reed Beds in Wastewater Treatment: Scope for Transgenic Plants
Chapter 12. Inspection of Crop Wild Relative (Cicer microphyllum) as Potential Genetic Resource in Transgenic Development
Chapter 13. Genome Modification Approaches to Improve Performance, Quality and Stress Tolerance of Mediterranean Fruit Species
Chapter 14. Key Challenges in Developing Products from Transgenic Plants
Chapter 15. Enhanced Production of Therapeutic Proteins in Plants: Novel Expression Strategies
Chapter 16. Transcriptional Engineering for Enhancing Valuable Metabolites in Photosynthetic Microalgae.

Contents:
Advances in postoperative pain management / Adam Young & Asokumar Buvanendran
The use of perioperative multimodal analgesia / Adam Young & Asokumar Buvanendran
The place for melatonin in postoperative analgesic regimens / Lars Peter Holst Andersen, Jacob Rosenberg & Ismail Gögenur
Perineural additives for peripheral nerve blocks / Gregory Schnepper & Sylvia H. Wilson
Linking regional anesthesia and analgesia with postoperative anticoagulation / Julie R. McSwain & Sylvia H. Wilson
Parent management of children's postoperative pain / Brooke Nicole Jenkins, Michelle A. Fortier & Zeev N. Kain
Billing and compliance for acute interventional perioperative pain / Mark E. Hudson.

Summary: The understanding and management of psoriasis have evolved dramatically over the last decades and, as a result, guidelines and treatment options have changed dramatically. To meet the need for a up-to-date practical resource in this area, the Editors have brought together a team of experts in the field to produce a highly informative and illustrated guide to the decision-making process for psoriasis. Advances in Psoriasis: A Multisystemic Guide provides physicians with a reference on the disease and its comorbidities and therapeutic options. It will help physicians further their knowledge of the science and therapy of psoriasis. As well as practicing dermatologists, fellows in dermatology will find this book to be an essential training resource to learn about the treatment and management of psoriasis.

Contents:
Introduction to Psoriasis and Psoriasis Therapy
Pathophysiology of Psoriasis/Novel Pathways
Psoriasis and Psoriasis Arthritis: Clinical Review and Update
Overview of Therapeutic Options/Pharmacology
Topical Therapy
Ultraviolet and Laser Therapy
Traditional Systemic Therapy
Biologics I: TNF Inhibitors
Biologics II: IL-12/23 and T-Cell Targeted Therapy
Research Pipeline I: Topicals and Oral Therapies
Research Pipeline II: Biologic Therapies
Summary of Published Treatment Guidelines
Reimbursement Issues/Aides
Patient Support Programs and Organizations
Conclusion
Appendix: Directory of Helpful Websites/Online Resources/Telephone Numbers.

Summary: This extensively revised second edition provides an up-to-date and highly informative textbook on psoriasis. The understanding of the mechanisms behind the disease and the available treatment options have continued to develop rapidly in recent times, with this vital resource covering the latest in these management options, including targeted T-cell therapy, the use of immunomodulators, systemic therapies, and ultraviolet and laser therapy. In addition, it provides a detailed overview of the pathophysiology, comorbidities, epidemiology and triggers of the disease. Advances in Psoriasis: A Multisystemic Guide extensively details the scientific basis and practice management of psoriasis. It is therefore a vital resource for practicing and trainee dermatologists looking to develop their clinical knowledge of how to manage and treat these patients.

Contents:
Introduction to and History of Psoriasis and Psoriasis Therapy
Pathophysiology of Psoriasis/Novel Pathways
Psoriasis: Clinical Review and Update
Psoriasis: Epidemiology, Potential Triggers, Disease Course
Topical Therapy I: Corticosteroids and Vitamin D Analogues
Topical Therapy II: Retinoids, Immunomodulators, and Others
Topical Therapy II: Retinoids, Immunomuodulators, and Others/ Ultraviolet Therapy for Psoriasis
Laser Therapy for Psoriasis
Traditional Systemic Therapy I: Methotrexate and Cyclosporine
Traditional Systemic Therapy II: Retinoids and Others
Apremilast
Etanercept
Adalimumab
Infliximab, Golimumab , and Certolizumab Pegol
Ustekinumab
Guselkumab
Tidrakizumab
Risankizumab
Secukinumab
Ixekizumab
Brodalumab
Biosimilars for Psoriasis
Research Pipeline I: Oral Therapeutics for Psoriasis
Research Pipeline II: Upcoming Biologic Therapies
Pediatric Psoriasis
Challenges in Psoriasis Treatment: Nail, Scalp, and Palmoplantar Involvement
Psoriasis and Comorbidities
Summary of Published Treatment Guidelines
Index.

Contents:
Combining radiotherapy and immunotherapy
SBRT and the treatment of oligometastatic disease
MRI guided radiotherapy
Oncologic applications of magnetic resonance guided focused ultrasound
Intensity-modulated proton beam therapy of prostate cancer- history, results, and future directions
IGRT and hypofractionation for primary tumors
The impact of IGRT on normal tissue toxicity
Biologic and image guided systemic radiotherapy
Cancer stem cells and tumor microenvironment in radiotherapy
Biomarkers and radiotherapy
The mammalian DNA damage response as a target for therapeutic gain in radiation oncology
Mathematical modeling in radiation oncology.

Contents:
Principles and developments in cancer immunotherapy and approaches for combination with tumour irradiation / Eckert, F., Huber, S.
Imageable biomarkers for radiotherapy response / van der Weg, WW., Span, P.N., Braam, P.M., Bussink, J.
Targeting tumor microenvironment and metabolism to overcome radiation resistance / Sharma, A., Pruschy, M.
Imaging for target volume definition and response assessment in lung cancer / De Ruysscher, D., van Elmpt, W.
Advances in technology and its application : radiotherapy treatment planning / Alber, M.
Stereotactic body radiotherapy / Guckenberger, M.
Clinical rationale and indications for particle therapy / Dreher, C, Combs, S.E.
Advances in radiation biology of particle irradiation / Helm, A., Tinganelli, W., Durante, M.
Preclinical mouse models for the evaluation of novel techniques in particle therapy / Schmid, T.E., Multhoff, G.

Summary: A considerable change in climate at a global level will impact the vegetable cultivation and agriculture as a whole; subsequently affecting the world's food supply. Climate change per se is not necessarily harmful; the problems arise from extreme events that are difficult to predict (erratic rainfall patterns and unpredictable high and low temperatures), and consequently reduce crop productivity. Vegetables are in general more succulent (have 90% water) and are more sensitive to climatic vagaries. Sudden changes in temperature coupled with irregular precipitation at any phase of crop growth can affect the normal growth, flowering, pollination, fruit setting, fruit development and fruit ripening can decrease the yield. The irregular precipitation can also affect the soil salinity and is a major challenge in many vegetable growing areas. To mitigate the harmful impact of climatic change there is a urgent need to develop adequate adaptation strategies for adverse effect of climate change and the preference should be given on development of heat, cold, drought, flood and salinity stress tolerant genotypes along with climate proofing through conventional and non-conventional breeding techniques. Available evidence shows that there is a high probability of increase in the frequency and intensity of climate related natural hazards due to climate change and hence increases the potential threat due to climate change related natural disasters in the world. This book (Volume- I) will be basically useful for the researchers and postgraduate students with current challenges and mitigation strategies for increasing vegetable production under a changing climate.

Contents:
Chapter 1. The Role of Research for Vegetable Production Under a Changing Climate: Future Trends and Goals
Chapter 2. Challenges and opportunities in vegetable production in changing climate: mitigation and adaptation strategies
Chapter 3. Selection of genotypes in vegetable crops for climate change adaptation
Chapter 4. Response of Solanaceous vegetables to increasing temperature and atmospheric CO2
Chapter 5. Climate change impact on cole crops and mitigation strategies
Chapter 6. Impact of climate change on root crops production and mitigation strategies
Chapter 7. Impact of climate change on leguminous vegetables productivity and mitigation strategies
Chapter 8. Impact of climate change on bulb crops production and mitigation strategies
Chapter 9. Impact of climate change on cucurbitaceous vegetables in relation to increasing temperature and drought
Chapter 10. Impact of carbon sequestration and greenhouse gasses on soils
Chapter 11. Impact of green house gasses on vegetable crops and atmosphere
Chapter 12. Impact of heat on vegetable crops and mitigation strategies
Chapter 13. Impact of drought and salinity on vegetable crops and mitigation strategies.

Contents:
The role of dysregulated microRNA expression in lung cancer / M. Krutakova [and seven others]
Laryngeal cancer: 12-year experience of a single center / V. Calkovsky, P. Wallenfels, A. Calkovska, A. Hajtman
Polymorphisms of selected DNA repair genes and lung cancer in chromium exposure / E. Halasova, [and nine others]
Associations of CYP1A2 polymorphisms with the risk haplotypes in lung cancer in the Slovak population
T. Matakova, E. Halasova, A. Dzian, R. Hruby, M. Halasa, K. Javorka, M. Skerenova
Impact of endobronchial ultrasound guided transbronchial needle aspiration on diagnostic yield of bronchoscopy in patients with mediastinal lymph node enlargement
K. Osinka, M. Zielińska-Krawczyk, P. Korczyński, B. Górnicka, R. Krenke
The effect on cognition of mitochondrial respiratory system proteins in peripheral blood mononuclear cells in the course of lung cancer
S. Michalak, J. Rybacka-Mossakowska, J. Gazdulska, I. Gołda-Gocka, R. Ramlau
Lung cancer and multiple neoplasms: a retrospective analysis
A. Romaszko, E. Świetlik, A. Doboszyńska, P. Szpruch, J. Luks
Humoral immune response against neural antigens and its effects on cognition in lung cancer patients
J. Rybacka-Mossakowska, R. Ramlau, J. Gazdulska, I. Gołda-Gocka, W. Kozubski and S. Michalak.
Active case finding among homeless people as a means of reducing the incidence of pulmonary tuberculosis in general population
J. Romaszko, A. Siemaszko, M. Bodzioch, A. Buciński, A. Doboszyńska
Cryptogenic organizing pneumonia: IL-1[beta], IL-6, IL-8, and TGF- [beta]1 serum concentrations and response to clarithromycin treatment
E. Radzikowska and [six others].

Summary: This book reviews the progress made in salivary diagnostics and identifies the likely direction of future endeavors. After an introductory section describing the histological and anatomical features of the salivary glands and salivary function, salivary collection devices and diagnostic platforms are reviewed. The field of ℓ́ℓsalivaomicsℓ́ℓ is then considered in detail, covering, for example, proteomics, the peptidome, DNA and RNA analysis, biomarkers, and methods for biomarker discovery. Salivary diagnostics for oral and systemic diseases are thoroughly discussed, and the role of salivary gland tissue engineering for future diagnostics is explored. The book closes by considering legal issues and barriers to salivary diagnostic development. Advances in Salivary Diagnostics will be an informative and stimulating reference for both practitioners and students.

Summary: Most crop plants grow in environments that are suboptimal, which prevents the plants from attaining their full genetic potential for growth and reproduction. Stress due to abiotic and biotic agents has a significant effect on world food production. Annually, an estimated 15% of global yields are lost, but this figure belies far greater losses for specific food systems and the people whose existence is dependent upon them, particularly in developing countries. Current efforts to mitigate these losses are worryingly over-reliant on the use of sophisticated and costly chemicals /measures with substantial economic and environmental costs, or on the development of efficient and smart crop varieties, which can take decades. What we need is a broad range of safe, robust and equitable solutions for food producers. One under-investigated approach is that of utilizing the crop plant's innate immune system to resist stress. More specifically, the innate immune system can be sensitized or 'primed' to respond more quickly and strongly to protect the plant against stresses. However, a strategy of employing priming in combination with reduced pesticide use can enhance protection, and help to meet commitments to reducing chemical inputs in agriculture. This book discusses in detail different segments of priming in addressing stress factors and traits to increase competitiveness against all odds. Adopting a holistic and systematic approach, it addresses priming to counter climate-change related adverse effects coupled with pest and pathogen related stress on the productivity of crops utilizing natural resources to reap sustainable environmental, economic and social benefits for potential productivity of crops, maintaining synergy between soil, water and plants in ways that mimic nature.

Contents:
Part 1. Concepts
Chapter1. Seed Priming: New Vistas and Contemporary Perspectives
Chapter 2. Impact of Seed Priming on The Modulation of Physico-Chemical and Molecular Processes During Germination, Growth and Development of Crops
Chapter 3. Seed Priming: An Emerging Technology to Impart Abiotic Stress Tolerance in Crop Plants
Chapter 4. Recent Advances in Abiotic Stress Tolerance of Plants Through Chemical Priming: An Overview
Chapter 5. Seed Priming Technology in the Amelioration of Salinity Stress in Plants
Chapter 6. Seed Priming with Plant Growth Regulators to Improve Crops Abiotic Stress Tolerance
Chapter 7. Addressing Stresses in Agriculture Through Bio-Priming Intervention
Chapter 8. Role of Microbial Seed Priming and Microbial Phytohormone in Modulating Growth Promotion and Defense Responses in Plants
Chapter 9. Potential Of Biopriming in Enhancing Crop Productivity and Stress Tolerance
Chapter 10. Stimulating Plant Tolerance Against Abiotic Stress Through Seed Priming
Part 2. Case Studies on Priming
Chapter 11. Seed Priming: A Low-Cost Technology for Resource-Poor Farmers in Improving Pulse Productivity
Chapter 12. Studies on Seed Priming in Pepper (Capsicum annuum L.)
Chapter 13. Effect of Different Seed Priming Treatments on Germination and Seedling Establishment of Two Threatened Endangered Medicinal Plant Of Darjeeling Himalaya
Chapter 14. Seed Priming on Germination, Growth and Flowering in Flowers and Ornamental Trees
Chapter 15. Role of SNP Mediated Nitric Oxide Priming in Conferring Low Temperature Tolerance in Wheat Genotype (Triticum aestivum L.): A Case Study in Indian Northern Plains
Chapter 16. Seedling Biopriming with Trichoderma spp. Enhances Nitrogen Use efficiency in Rice.

Contents:
Chapter 1. Anatomy
Chapter 2. Biomechanics
Chapter 3. Kinematics and Motion Analysis
Chapter 4. Advanced MR Imaging of the Shoulder
Chapter 5. Transosseous-Equivalent Arthroscopic Bankart Repair by Twin Anchor Footprint Fixation (TAFF) Technique using JuggerKnot Soft Anchor
Chapter 6. Complications of Arthroscopic Surgery
Chapter 7 Instability
Chapter 8. Arthroscopic Rotator Cuff Repair
Chapter 9. Mini-Open Rotator Cuff Repair
Chapter 10. Massive and Irreparable Rotator Cuff Tears
Chapter 11. Superior Capsule Reconstruction for Massive Rotator Cuff Tears
Chapter 12. Tendon Transfer for Massive Rotator Cuff Tear
Chapter 13. Frozen Shoulder
Chapter 14. Nerve Lesions Around the Shoulder
Chapter 15. Proximal Humeral Fractures - Classification and Treatment
Chapter 16. Reverse Shoulder Arthroplasty
Chapter 17. Physical Therapy- Tips and Pitfalls.

Summary: This book describes current and emerging techniques in hip surgery, providing the essential, up-to-date knowledge that will be required by the orthopaedic surgeon who plans to become a specialist hip surgeon. The opening chapter offers a concise overview of the surgical anatomy, with particular attention to details relevant to the surgical techniques outlined in the book. The increasingly popular anterior minimally invasive approach to the hip and a microinvasive variation of this approach are then described. Subsequent chapters present surgical approaches to developmental disorders of the hip, including dysplasia and femoroacetabular impingement, and promising hip preservation techniques for avascular necrosis of the hip - an often neglected but internationally relevant disease that can mutilate the hip in young patients. Finally, the latest techniques and implants for primary and revision hip arthroplasty are discussed in depth. The international author team consists of recognized leaders in the field, many of whom have developed the described classifications and new surgical techniques.

Contents:
Part I. Anatomy of the hip and its surgical application
Surgical Anatomy of the Hip
The minimally invasive direct anterior approach to the hip
Part II. Maturity disorders of the hip
Hip dysplasia: Osteotomies around the hip in childhood
Pelvic osteotomies: The Periacetabular Osteotomy Technique for Patients with Developmental Dysplasia of the Hip
Navigated Rotational Acetabular Osteotomy
Part III. Arthroscopy of the hip
Hip arthroscopy and impingement
Evolution, Current Concepts and Future Developments in Arthroscopic Surgery of the Hip
Current concepts in the management of femoroacetabular impingement
Part IV Osteonecrosis of the femoral head: Promising hip preservation surgery techniques
Current state of diagnosis and treatment of osteonecrosis of the femoral head
Femoral Osteotomies for Osteonecrosis of the Femoral Head
Stem cell therapy for the treatment of hip osteonecrosis
Alternative Head Preserving Procedure for Osteonecrosis of the Femoral Head: Tissue Engineering, Future Perspective
Part V. Arthritis of the hip: Primary hip arthroplasty
Ceramic-on-ceramic Total Hip Arthroplasty
Highly cross-linked polyethylene bearing
Metal-on-metal Total Hip Arthroplasty
First experience with ceramic-on-ceramic hip resurfacing
Cup positioning using anatomical landmarks of the acetabulum
Intra-operative measurement of cementless stem anteversion
Part VI Arthritis of the hip: Revision Hip Arthroplasty
Triflange cup and 3D-printing
Trochanteric osteotomy
Acetabular defects and their treatment
Surgical Management of Femoral Bone Loss.

Contents:
Front Matter
Structure and Function
Structure and Function. Morphology and Function of the Cruciate Ligaments / Hilde de Rooster, Eithne Comerford
Biomechanics of the Cruciate Ligaments / Susannah J Sample
Cruciate Ligament Remodeling and Repair / Connie S Chamberlain, Erin E Crowley, Ray Vanderby
Meniscal Structure and Function / Antonio Pozzi, James L Cook
Biomechanics of the Normal and Cranial Cruciate Ligament-Deficient Stifle / Antonio Pozzi, Stanley E Kim
Etiopathogenesis of Cruciate Ligament Rupture
Etiopathogenesis of Cruciate Ligament Rupture. Histology of Cruciate Ligament Rupture / Kei Hayashi
Genetics of Cruciate Ligament Rupture / Lauren A Baker, Peter Muir
Cruciate Ligament Matrix Metabolism and Development of Laxity / Eithne Comerford
Morphological Risk Factors for Cruciate Ligament Rupture / Eithne Comerford
Role of Nitric Oxide Production and Matrix Protease Activity in Cruciate Ligament Degeneration / David E Spreng, Simone Forterre
Role of Antibodies to Collagen Type I and II / Hilde de Rooster, Eithne Comerford
Synovitis Precedes Stifle Instability Associated with Cruciate Ligament Rupture / Jason A Bleedorn
Role of Synovial Immune Responses in Stifle Synovitis / Peter Muir
Clinical Features
Clinical Features. Epidemiology of Cruciate Ligament Rupture / Lauren A Baker, Peter Muir
History and Clinical Signs of Cruciate Ligament Rupture / Peter Muir
Partial Rupture of the Cranial Cruciate Ligament / Peter Muir
Caudal Cruciate Ligament Rupture / Peter Muir
Stress Imaging of the Stifle / Stanley E Kim
Stifle Ultrasonography / Cristi R Cook
Computed Tomography (CT) of the Stifle / Ingrid Gielen, Henri van Bree
Magnetic Resonance Imaging of the Stifle / Peter V Scrivani
Risk Prediction of Cruciate Ligament Rupture using Stifle Diagnostic Imaging / Peter Muir
Surgical Treatment
Surgical Treatment. Arthroscopy and Arthrotomy of the Stifle / Brian S Beale, Donald A Hulse, Antonio Pozzi, Peter Muir
Joint Lavage / Peter Muir
Extracapsular Stabilization / Selena Tinga, Stanley E Kim
Intra-Articular Repair for Cranial Cruciate Ligament Rupture in the Dog / Jeffery J Biskup, Michael G Conzemius
Tibial Plateau Leveling Osteotomy / Susan L Schaefer
Tibial Tuberosity Advancement / Randy J Boudrieau
Closing Cranial Wedge Ostectomy and Triple Tibial Osteotomy / Simon C Roe
Treatment of Excessive Tibial Plateau Angle / Michael P Kowaleski
Surgical Management of Cruciate Ligament Rupture Combined with Patella Luxation / Anke Langenbach, Denis J Marcellin-Little
Biomechanics of the Cranial Cruciate Ligament-Deficient Stifle Treated by Tibial Osteotomies / Antonio Pozzi, Stanley E Kim, Selena Tinga
Arthroscopic Follow-Up after Surgical Stabilization of the Stifle / Brian S Beale, Donald A Hulse
Cranial Cruciate Ligament Debridement / David E Spreng
Surgical Treatment of Concurrent Meniscal Injury / Samuel P Franklin, James L Cook, Antonio Pozzi
Meniscal Release / Antonio Pozzi, James L Cook
Progression of Osteoarthritis after Stifle Stabilization Surgery / Susannah J Sample
Clinical Outcomes after Surgical Treatment of Cruciate Ligament Rupture / Mary Sarah Bergh, Steven C Budsberg
Success and Failure after Stifle Stabilization Surgery / Michael G Conzemius, Richard B Evans
Diagnosis and Management of Orthopaedic Infection after Stifle Surgery / Noël MM Moens
Medical Management of Cruciate Ligament Rupture
Medical Management of Cruciate Ligament Rupture. Medical Therapy for Stifle Osteoarthritis / Steven C Budsberg
Rehabilitation for Dogs with Cruciate Ligament Rupture / Denis J Marcellin-Little, Courtney J Arnoldy
Future Directions
Future Directions. Clinical Research Design and Patient-Oriented Outcomes / Dorothy Cimino Brown
Total Knee Replacement in the Dog / Matthew J Allen, William D Liska, Valentina Brioschi
Regenerative Medicine and Cranial Cruciate Ligament Repair / Gabriel S Perrone, Martha M Murray, Patrick Vavken
Disease-Modifying Medical and Cell-Based Therapy / Susannah J Sample, Peter Muir.

Contents:
Advances in the management of peritoneal carcinomatosis / Jesus Esquivel
Peritoneal carcinomatosis: signs and symptoms / Kimberly L. Levinson & Jerome L. Belinson
Peritoneal carcinomatosis: radiologic diagnosis / Brian C. Allen & Perry Shen
Surgical management of peritoneal carcinomatosis / Aaron U. Blackham & John H. Stewart
Surgical management of peritoneal carcinomatosis in ovarian cancer / Sareena Singh, Amy Armstrong & Robert DeBernardo
Chemotherapy in peritoneal carcinomatosis of gastrointestinal origin / Jesus Esquivel & Jörg Pelz
Chemotherapy of peritoneal disseminations of colorectal origin / Dario Baratti, Shigeki Kusamura & Marcello Deraco
The use of heated intraperitoneal chemotherapy for the treatment of gynecologic carcinomatosis / Sarah K. Goodrich
Follow-up tools and strategies after CRS and HIPEC for peritoneal surface malignancies / Benedikt M.J. Lampl, Hubert Leebmann, Max Mayr & Pompiliu Piso
Prognosis / Yutaka Yonemura, Haruaki Ishibashi & Emel Canbay
Pseudomyxoma peritonei as a special subset of peritoneal carcinomatosis / Shreya Shetty, Peter Thomas, Venkatesh Govindarajan, Poonam Sharma, Gopi Sirineni & Brian W. Loggie.

Contents:
Insomnia moves front and center among sleep disorders / William Vaughn McCall
Insomnia in the setting of mental illness / Carmen G. Black & William Vaughn McCall
Insomnia comorbid with medical disorders / Stephen Lund
Insomnia in the setting of cancer / Julieta Scalo & Karen Rascati
Cognitive-behavioral therapy for insomnia / Melanie K. Leggett
Pharmacotherapy for insomnia / Julieta Scalo & Karen Rascati
Role of zolpidem in the management of primary and comorbid insomnia
Jaime M. Monti & Seithikurippu R. Pandi-Perumal
Index.

Summary: A comprehensive book that reviews advances in ocular motor research on topics of general interest, rare, specialized or unique conditions, and pertinent basic neuroscience. A rare collection with contributions from basic neuroscientists, neurologists, and ophthalmologists. Includes dedicated chapters on mathematical models, pharmacotherapy, neuromodulation, motion perception, visual influence on eye movement, physiology of strabismus, and microsaccades. This book is dedicated to David Robinson - one of the pioneers of contemporary ocular motor and vestibular neuroscience.

Summary: This book provides an informative update on scientific advances relating to transplant dermatology that may be applicable to clinical practice. Commentary is provided on the emerging role of viruses in transplant dermatology, the management of skin disease secondary to transplant medication, sunscreen use in transplant recipients, the role of revision of immunosuppression, and advances in photodynamic therapy. The latest staging and management criteria for high-risk squamous cell carcinoma and the implications for clinical practice are then analyzed. Finally, the management of other cutaneous malignancies is discussed, covering malignant melanoma, Merkel cell carcinoma, and rarer tumors that also behave aggressively and require special consideration in solid organ transplant patients. Each particular advance is addressed in an individual chapter by leaders in the field. The book both expands current knowledge and complements previous textbooks on the subject.

Contents:
Transplantation today
De novo malignancies after solid organ transplantation: focus on viral infection
Update on benign and inflammatory skin disease secondary to transplant medication
Update on photoprotection and sunscreen use in solid organ transplant recipients
Update on our understanding of HPV as a risk factor for cutaneous SCC in organ transplant recipients
Advances in our understanding of immunosuppression as a risk factor for cutaneous SCC: evidence for revision of immunosuppressive therapy
Advances in photodynamic therapy for the treatment of malignant and pre-malignant lesions in transplant dermatology
Update on staging, definition and chemoprevention of ?high risk SCC? in organ transplant recipients
Advances in management of "high risk SCC" in organ transplant recipients
Advances in management of Merkel cell carcinoma in organ transplant recipients; role of polyoma virus and immunosuppression
Update in melanoma in organ transplant recipients
Update on unusual tumors in organ transplant recipients. .

Summary: This volume describes the most relevant and cutting-edge technological news on the complex surgical procedure of acoustic neuroma. The clinical-radiological diagnosis and surgical indications are briefly presented and the surgical technique is illustrated step-by-step: video clips show the latest means of treating these patients. All these indications were prepared by highly experienced experts in the field, based on their personal experience. The new technologies discussed concern e.g. the intraoperative identification and position of the facial nerve, hearing preservation, techniques for dural closure, and the usefulness of laser and ultrasound aspirators. The book also discusses a number of ongoing projects, including those on: diluted papaverine for microvascular protection of cranial nerves, flexible endoscope for IAC control of tumor removal, fluid cement for bone closure, administering aspirin to control residual tumors larger than 7mm, and DTI for preoperative prediction of the position of the facial nerve.

Summary: This book presents the state of the art in genetic eye research in Asia and the Pacific. Though there has been an explosion of information on genetic eye research in western countries, more than sixty percent of the human genes involved in eye diseases in the Asian and Pacific population remain unknown. However, new efforts and a new awareness have sparked important discussions on the subject, and new plans are being implemented to discover the genes responsible for many eye diseases in the population. The book reviews the latest findings; its content ranges from genetic aspects of human migration to DNA sequence analysis, genome-wide association analysis, and disease phenotypes. The efforts of the Asian Eye Genetic Consortium (AEGC) are also discussed. The book's editors have been instrumental in developing strategies for discovering the new Asian genes involved in many eye diseases. All chapters were written by leading researchers working on Asian eye genetics from the fields of Human Genetics, Ophthalmology, Molecular Biology, Biochemistry, Sensory Sciences, and Clinical Research. Advances in Vision Research, Volume I will prove to be a major resource for all researchers, clinicians, clinical researchers, and allied eye health professionals with an interest in eye diseases among the Asian population.

Contents:
1. Asian eye genetics consortium (AEGC)
2. Japan eye genetics consortium (JEGC) for hereditary retinal diseases
3. Whole genome sequencing in genetic eye diseases
4. Targeted exome sequencing in japanese patients with retinitis pigmentosa
5. Genetic epidemiology of congenital cataracts and autosomal recessive retinal degenerations in Pakistan
6. Genetics of cataract in Asia: an overview of research in congenital and age-related cataract with emphasis on Indian population
7. genetic analysis of families with retinal dystrophies
8. Whole genome sequencing in patients with rretinitis pigmentosa
9. Retinitis pigmentosa in Korean patients
Retinitis pigmentosa in China
11. Retinitis pigmentosa in Japanese population
12. Cone dysfunction syndrome in the Japanese population
13. Leber Congenital amaurosis/early-onset retinal dystrophy in Japanese population
14. Paradigm of susceptibility genes in AMD and PCV
15. Genetics and pathology of inflammatory components on AMD
16. Genome-wide association study of age-related eye diseases in Chinese population
17. Clinical genetics of retinoblastoma: an Asian perspective
18. Molecular and clinical genetics of retinoblastoma
19. Current research perspectives in understanding diabetic retinopathy
20. Genome-wide association studies of glaucoma
21. Genetic complexity of primary angle-closure glaucoma in asians
22. Genotype-phenotype correlation for POAG in the Middle East and other populations
23. Corneal dystrophies in India
24. Genetics of corneal endothelial dystrophies: an Asian perspective
25. Keratoconus in Asia
26. Genetics of pediatric eye diseases and strabismus in Asia
27. Keratoconus: globally and in the Middle East (epidemiology, genetics, and future research)
28. Genetics of myopia
29. Ocular implications of gaucher disease
30. Genetic background of uveitis in chinese population
31. Usher syndrome in Chinese and Japanese population
32. Homozygosity mapping for autosomal recessive ocular diseases
33. Tools of genetic eye research and need for clinical research collaborations
34. Eye genetics: the road ahead to quality standards
35. Genetic counseling in Asia
36. Epigenetic study in asian eye diseases
37. Unique genetic signatures in Asian age-related macular degeneration: an opportunity for drug development
38. A perspective: how gene therapeutics can help address global health issues.

Summary: This third volume, with three supporting editors, broadens its focus on genetic eye research from the Asian to the global scale. New efforts and a new awareness have sparked important discussions on genetic eye research, and new plans are being implemented to identify the genes responsible for numerous eye diseases. The book introduces the latest findings on genetics in eye diseases, gene therapy, and genome-wide association analysis, and the efforts of the Global Eye Genetic Consortium (GEGC). The books editors have been instrumental in developing strategies for discovering the new genes involved in many eye diseases. All chapters were written by leading researchers working on eye genetics from the fields of Human Genetics, Ophthalmology, Molecular Biology, Biochemistry, Sensory Sciences, and Clinical Research. Advances in Vision Research, Volume III is a major resource for all researchers, clinicians, clinical researchers, and allied eye health professionals with an interest in eye diseases around the globe.

Contents:
1. Expansion of Asian Eye Genetics Consortium (AEGC) to Global Eye Genetics Consortium (GEGC), Introduction of a global Phenotype-Genotype Database "GenEye" and Launch of New Training Programs at National Eye Institute (NEI)
2. Global Womens Eye Health: a Genetic Epidemiologic perspective
3. Establishing the Chinese Arm of GEGC
4. Human material for research: Eye banking, biobanking and ethical access
5. Current Understanding of Polypoidal Choroidal Vasculopathy
6. Genetics of Age-related macular degeneration (AMD) in Asia
7. The contribution of rare allele and Junk Genome in AMD pathogenesis
8. Differential genotypes in age-related macular degeneration and polypoidal choroidal vasculopathy: a updated meta-analysis
9. Genetic Epidemiology of Quantitative Traits of Primary Open Angle Glaucoma
10. Association studies on retina diseases in Chinese population
11. Congenital stationary night blindness (CSNB) an inherited retinal disorder where clear correlations can be made
12. Genome analysis for inherited retinal disease: the state of the art
13. Generation and analysis of induced photoreceptor-like cells from fibroblasts of patients with retinitis pigmentosa
14. Genotype-phenotype of RPE65 mutations: A reference guide for gene testing and its clinical application
15. Genetic variants and impact in PDE6B rod-cone dystrophy
16. The retinitis pigmentosa genes
17. Primary Congenital Glaucoma Genetics The Experience in Brazil
18. Glaucoma genetics in Pakistan
19. Contributions of Promoter Variants to Complex Eye Diseases
20. Vascular Basement Membrane Thickening Basis of disease pathology in diabetic retinopathy
21. Molecular Genetics and Clinical aspects of Macular Corneal Dystrophy
22. Congenital and Inherited Cataracts
23. Higher order aberrations: differences among populations from various demographics
24. Genetics Of Microphthalmia: Global And Indian Perspectives
25. Regional Differences in Prevalence of Myopia: Genetic or Environmental Effects?
26. Consortium for Refractive Error and Myopia (CREAM): Vision, Mission and Accomplishments
27. Oncologic properties of retinoblastoma genes
28. Oncologic implications of genetic and epigenetic basis of pterygium
29. The need for alternative therapies in eye disorders
30. Gene Therapy and Retinal Disease
31. The use of human pluripotent stem cells (hPSCs) and CRISPR-mediated gene editing in retinal diseases.

Summary: "Advancing Diversity, Inclusion, and Social Justice through Human Systems Engineering highlights how scholars and practitioners of HSE (inclusively defined to span many fields) can apply their theories and methods to understand and support healthy communities, include and empower diverse populations, and inspire strategies for a more inclusive future. This volume brings together experts from human factors, ergonomics, psychology, human-computer interaction, and more to demonstrate how these fields can be applied to societal challenges and solutions. Through a blend of research reports, literature reviews, and personal narratives, this volume explores these issues from the individual to the global scale, across diverse populations, and across multiple continents"-- Provided by publisher.

Contents:
Preface: Inclusive scholarship for inclusive systems
Section 1. Understanding and supporting healthy communities. Human systems engineering for societal transformation : a tale of two cities
Inclusive decision-making : applying human factors methods to capture the needs and voices of marginalized populations
HFE in underdeveloped countries : how do we facilitate equitable, egalitarian, and respectful progress?
Researcher reflections on human factors and health equity
The intersection of human factors engineering and health equity
Using work domain analysis to advocate for social justice : meeting the needs of resource-constrained societies
Section 2. Including and empowering diverse people. A human factors engineer's journey into enhancing LGBT status is academia
All are welcome but terms and conditions apply
"Nothing about us without us" transforming participatory research and ethics in human systems engineering
Ergonomic analysis of working conditions of a recycler community in Medellín, Colombia
Guiding technology design to empower older adults to actively engage in society
Inclusive wearable design : developing a set of characteristics of socially acceptable BCI devices for women
Section 3. Inspiring strategies for an inclusive future. Automation, work, and racial equity : how human systems engineering can shape the future of work
The learning research and development center summer undergraduate research internship : a diversity internship in the learning sciences
Facilitating a sense of belonging for women of color in engineering : the case for virtual internships
Leading an EDI strategy in a UK university : reflections from an HFE professional
Developing an effective diversity training intervention : best practices and challenges
Reimagining community-based research and action in human factors : a dialogue across disciplines.

Summary: The book provides an introduction to the basics of fungi, discussing various types ranging from edible mushrooms to Neurospora - a model system for genetics and epigenetics. After addressing the classification and biodiversity of fungi, and fungi in different ecological niches, it describes the latest applications of fungi, their role in sustainable environments and in alleviating stress in plants, as well as their role in causing plant and animal diseases. Further chapters explore the advances in fungal interactions research and their implications for various systems, and discuss plant-pathogen interactions. The book also features a section on bioprospecting, and is an extremely interesting and informative read for anybody involved in the field of mycology, microbiology and biotechnology teaching and research.

Contents:
Intro; Foreword; References; Preface; Contents; About the Editors and Contributors; Part I: Basic Aspects of Fungi;
1: The Mystical World of Mushrooms; 1.1 Introduction; 1.2 History of Mushroom Research and Cultivation; 1.2.1 International Developments; 1.2.2 Indian Scenario of Mushroom Research and Cultivation; 1.3 Taxonomy of Mushroom; 1.3.1 Phylum: Ascomycota; 1.3.2 Phylum: Basidiomycota; 1.4 Magnitude of Mushroom Species; 1.4.1 Edible Mushroom Types; 1.5 Cultivation Potential of Mushroom; 1.5.1 Temperate Mushrooms; 1.5.1.1 Button Mushroom: Agaricus bisporus 1.5.1.2 Shiitake Mushroom: Lentinula edodes1.5.1.3 Flammulina Velutipes; 1.5.2 Subtropical Mushrooms; 1.5.2.1 Agaricus Bitorquis; 1.5.2.2 Oyster Mushrooms: Pleurotus Spp.; 1.5.2.3 Black Ear Mushroom: Auricularia Spp.; 1.5.2.4 Black Poplar Mushroom (Agrocybe aegerita); 1.5.3 Subtropical Mushrooms; 1.5.3.1 Paddy Straw Mushroom: Volvariella Spp.; 1.5.3.2 Milky Mushroom: Calocybe Indica; 1.6 Nutritional and Medicinal Properties of Mushrooms; 1.6.1 Proteins; 1.6.2 Vitamins; 1.6.3 Minerals; 1.6.4 Carbohydrate and Fiber; 1.6.5 Fat; 1.6.6 Energy Value; 1.6.7 Moisture 1.7 Medicinal Values of Mushroom1.7.1 Health Effects of Medicinal Mushroom; 1.7.2 Health and Nutritional Benefits of Eating Mushrooms; 1.8 Cultivation Methods of Different Mushrooms; 1.8.1 Oyster Mushroom Cultivation; 1.8.1.1 Advantages of Growing Oyster Mushroom; Difference of Substrates; Choice of Species; Simple Cultivation Technologies; Longer Shelf Life; High Productivity; 1.8.1.2 Steps in Oyster Mushroom Cultivation; Spawn Preparation; Preparation of Substrate; Sterilization of Substrate; Steam Sterilization; Hot Water Sterilization; Chemical Sterilization; Bed Preparation 1.8.3 Cultivation of Button Mushroom (Agaricus bisporus)1.8.3.1 Compost Preparation; Vegetative-Based Material; Animal Manure; Nitrogen Fertilizer; Carbohydrate Sources; Concentrated Meals; Supplementation to Rectify Mineral Deficiencies; 1.8.3.2 Methods of Composting; Long Method of Composting; Phase I; Phase II; 1.8.3.3 Bulk Pasteurization; Infrastructure; Machinery Required; Spawning; Casing; Casing Pasteurization and Application; Cropping; Crop Management; References;
2: The Developmental History of Ustilago maydis: A Saprophytic Yeast, a Mycelial Fungus, Mushroom-Like, and a Smut Crop Management and HarvestingIncubation; Fruit Body Induction; Temperature; Relative Humidity; Oxygen and Carbon Dioxide Requirements; Harvesting; 1.8.2 Cultivation of Milky Mushroom (Calocybe indica); 1.8.2.1 Spawn Preparation for Calocybe indica; 1.8.2.2 Substrate Preparation and Treatment; Chemical Steeping Treatment; Hot Water Treatment of the Substrate; 1.8.2.3 Bed Filling and Spawning of the Substrate; 1.8.2.4 Care and Maintenance after Spawning; 1.8.2.5 Casing; 1.8.2.6 Aftercare and Management During Production; 1.8.2.7 Harvesting; Production/Yield

Summary: This book presents a unique concept of merging nanotechnology and novel urinary biomarkers for accurate early prostate cancer detection, discussing an entire progressive pipeline of innovative new strategies in biosensor development, from a simple colorimetric system to a complex system for simultaneous multiple biomarker sensing. For newcomers to the field of nucleic acid biosensing, it also describes various isothermal amplification and amplification-free strategies, which are currently the main research areas. Lastly, the book introduces and demonstrates the notion of clinical nanobiosensor validation toward clinical translation: the ultimate aim of researchers in the biosensor field. This book is a valuable reference resource learners seeking inspiration for cancer biosensor development.

Contents:
Intro; Supervisor's Foreword; Parts of this thesis have been published in the following journal articles:; Acknowledgements; Contents; Abbreviations; 1 Unifying Next-Generation Biomarkers and Nanodiagnostic Platforms for Precision Prostate Cancer Management; 1.1 Introduction; 1.2 Next-Generation PCa Biomarkers; 1.3 Existing and Emerging Biomarker-Directed PCa Screening Diagnostics; 1.4 Nano-strategies for Next-Generation PCa Biomarker Detection; 1.5 Challenges in Clinical Translation of Novel Biomarkers and Nano-strategies; 1.6 Conclusions and Future Outlook; References 2 Colorimetric Gene Fusion Diagnostics for Visual Binary Readout2.1 Introduction; 2.2 Materials and Methods; 2.3 Results and Discussion; 2.4 Conclusions; References; 3 Label-Free Surface-Enhanced Raman Scattering Detection System for Clinical Biomarker Targets; 3.1 Introduction; 3.2 Materials and Methods; 3.3 Results and Discussion; 3.4 Conclusions; References; 4 Amplification-Free Electrochemical RNA Biomarker Sensing; 4.1 Introduction; 4.2 Materials and Methods; 4.3 Results and Discussion; 4.4 Conclusions; References 5 Simultaneous Analysis of Multiple Biomarkers via High-Throughput Parallel Profiling5.1 Introduction; 5.2 Materials and Methods; 5.3 Results and Discussion; 5.4 Conclusions; References; 6 Clinical Evaluation of Non-invasive Nanodiagnostics for PCa Risk Stratification; 6.1 Introduction; 6.2 Materials and Methods; 6.3 Results and Discussion; 6.4 Conclusions; References; 7 Summary and Future Work; 7.1 Summary; 7.2 Future Work; Curriculum Vitae

Summary: This book provides a unique perspective on the biomedical and societal implications of personalized medicine and how it helps to mitigate the healthcare crisis and rein in ever-growing expenditure. It introduces the reader to the underlying concepts at the heart of personalized medicine. An innovative second edition, this book functions as an update to the successful first edition to include new, state-of-the-art information and advancements in the fast-paced field of personalized medicine. Chapters examine pharmacogenomics, targeted therapies, individualized diagnosis and treatment, and cancer immunotherapies. The book also features an essential discussion on how the advent of genomic technologies gives clinicians the capability to predict and diagnose disease more efficiently and offers a detailed up-to-date compilation of clinical trials in cancer leading to breakthrough therapies. The book also addresses the impact of Big Data on personalized medicine and the newfound applications of digital health and artificial intelligence. A work that advocates for a patient-centered approach, Advancing Healthcare Through Personalized Medicine, Second Edition is an invaluable text for clinicians, healthcare providers, and patients.

Contents:
1. Introduction: Biomedical Innovation and Policy in the Twenty-First Century
2. The Rise of Genomics and Personalized Medicine
3. Patient Narratives: Personalized Medicine in the Field
4. Alliances: Knowledge Infrastructures, and the Digitization of Precision Health
5. Tumor Genesis and Precision Oncology
6. Trends in Precision Oncology and Precision Medicine 2.0
7.Personalized medicines impact on disease
8. The Genome in the Clinic and Boardroom: Biomarkers, Diagnosis, Treatment, and Education
9. A New Set of Clinical tools for Physicians
10. Legislation, Reimbursement and the Regulatory Landscape
11. Translational personalized medicine: Molecular profiling, druggable targets, and clinical genomic medicine
12. The Health Economics of Personalized Precision Medicine
13. Moral, Societal and Ethical Issues: Claims, Consequences, and Caveats
14. Conclusion.

Summary: This open access book gives an overview of the sessions, panel discussions, and outcomes of the Advancing the Science of Cancer in Latinos conference, held in February 2018 in San Antonio, Texas, USA, and hosted by the Mays Cancer Center and the Institute for Health Promotion Research at UT Health San Antonio. Latinos - the largest, youngest, and fastest-growing minority group in the United States - are expected to face a 142% rise in cancer cases in coming years. Although there has been substantial advancement in cancer prevention, screening, diagnosis, and treatment over the past few decades, addressing Latino cancer health disparities has not nearly kept pace with progress. The diverse and dynamic group of speakers and panelists brought together at the Advancing the Science of Cancer in Latinos conference provided in-depth insights as well as progress and actionable goals for Latino-focused basic science research, clinical best practices, community interventions, and what can be done by way of prevention, screening, diagnosis, and treatment of cancer in Latinos. These insights have been translated into the chapters included in this compendium; the chapters summarize the presentations and include current knowledge in the specific topic areas, identified gaps, and top priority areas for future cancer research in Latinos. Topics included among the chapters: Colorectal cancer disparities in Latinos: Genes vs. Environment Breast cancer risk and mortality in women of Latin American origin Differential cancer risk in Latinos: The role of diet Overcoming barriers for Latinos on cancer clinical trials Es tiempo: Engaging Latinas in cervical cancer research Emerging policies in U.S. health care Advancing the Science of Cancer in Latinos proves to be an indispensable resource offering key insights into actionable targets for basic science research, suggestions for clinical best practices and community interventions, and novel strategies and advocacy opportunities to reduce health disparities in Latino communities. It will find an engaged audience among researchers, academics, physicians and other healthcare professionals, patient advocates, students, and others with an interest in the broad field of Latino cancer.

Contents:
Chapter 1: Advancing the Science of Cancer in Latinos
Chapter 2: Disaggregated Hispanic Groups and Cancer: Importance, Methodology and Current Knowledge
Chapter 3: Colorectal Cancer Disparities in Latinos: Genes vs. Environment
Chapter 4: Breast Cancer Risk and Mortality in Women of Latin American Origin
Chapter 5: Prostate Cancer in U.S. Latinos: What Have We Learned and Where Should We Focus Our Attention
Chapter 6: Differential Cancer Risk in Latinos: The Role of Diet
Chapter 7: Biomarkers of Gastric Pre-Malignant Lesions
Chapter 8: Molecular Subtypes and Driver Mutations in Latinos with Gastric Cancer: Implications for Etiological and Translational Research
Chapter 9: The Biology of Breast Cancer Disparities in Hispanics: Current Knowledge, Gaps and Research Opportunities
Chapter 10: Molecular Profiles of Breast Cancer in Hispanic/Latina
Chapter 11: Biomarkers and Precision Medicine in Oncology Practice and Clinical Trials
Chapter 12: Overcoming Barriers for Latinos on Cancer Clinical Trials
Chapter 13: Breast Cancer Precision Medicine in Hispanics/Latinas: Focus on Luminal B Tumors
Chapter 14: Is Precision Medicine Widening Cancer Care Disparities in Latino Populations? The Rutgers Cancer Institute of New Jersey Experience
Chapter 15: A Vision for Improving Quality of Life Among Spanish-Speaking Latina Breast Cancer Survivors
Chapter 16: Research Democracy in a Randomized Controlled Trial: Engaging Multiple Stakeholders in Patient-Centered Outcomes Research
Chapter 17: Es Tiempo: Engaging Latinas in Cervical Cancer Research
Chapter 18: Reaching Latinos Through Social Media and SMS for Smoking Cessation
Chapter 19: The Need for a Holistic Approach to Prevent Reproductive Cancers among US Latinas: The Potential Impact of Normalizing Sexuality and Improving Communication
Chapter 20: Critical Steps for Engaging Hispanics in Cancer Research: Building Capacity to Enhance Participation in Biospecimen Donation with Hispanic Communities
Chapter 21: Emerging Policies in US Health Care
Chapter 22: A Way Forward: The Future of Cancer Health Disparities Research in Latinos.

Summary: This open access book is a collection of articles based on presentations from the 2020 Advancing the Science of Cancer in Latinos conference that gives an overview of conference outcomes. The vision of the conference has been to unite researchers, scientists, physicians and other healthcare professionals, patient advocates and students from across the world to discuss research advancements, identify gaps, and develop actionable goals to translate basic research findings into clinical best practices, effective community interventions, and professional training programs to decrease cancer risks and eliminate cancer disparities for Latinos. This conference comes at an especially important time when Latinos the largest and youngest minority group in the U.S. are expected to face a 142% rise in cancer cases in the coming years. Disparities continue to impact this population in critical areas: access to preventive and clinical care, changeable risk behaviors, quality of life, and mortality. Each chapter summarizes the presentation and includes current knowledge in the specific topic areas, identified gaps, and opportunities for future research. Topics explored include: Applying an Exposome-Wide (ExWAS) Approach to Latino Cancer Disparities Supportive Care Needs and Coping Strategies Used by Latino Men Cancer Survivors Optimizing Engagement of the Latino Community in Cancer Research Latino Population Growth and the Changing Demography of Cancer Implementation Science to Enhance the Value of Cancer Research in Latinos A Strength-Based Approach to Cancer Prevention in Latinxs Overcoming Clinical Research Disparities by Advancing Inclusive Research Advancing the Science of Cancer in Latinos: Building Collaboration for Action will appeal to a wide readership due to its comprehensive coverage of topics ranging from basic science and community prevention research to clinical practice to policy. The book is an essential resource for physicians and other medical professionals, researchers, scientists, academicians, patient advocates, and students. It also will appeal to policy-makers, NCI-designated cancer centers, academic centers, state health departments, and community organizations.

Contents:
Part I . Introduction
Chapter 1. Advancing the Science of Cancer in Latinos
Part II. Health Threats in the Latino Community
Chapter 2. Applying an Exposome-Wide (ExWAS) Approach to Latino Cancer Disparities
Chapter 3. Population Health Challenges for Latinos in the US
Part III. Vulnerable Populations and Cancer Health Disparities
Chapter 4. Acute and Long-Term Neurological Complications of Acute Lymphoblastic Leukemia (ALL) Therapy in Latino Children
Part IV. Cancer Outcomes and Survivorship in Latinos
Chapter 5. Supportive Care Needs and Coping Strategies Used by Latino Men Cancer Survivors
Chapter 6. Cancer Care Delivery Among Breast Cancer Patients: Is It the Same for All?
Part V. Cancer in the Era of Precision Medicine
Chapter 7. Genetic Ancestry and Breast Cancer Subtypes in Hispanic/Latina Women
Chapter 8. Precision Medicine Approaches for Stratification and Development of Novel Therapies of Latin(x) Patients at Risk of Lung Malignancy
Part VI. Engaging Latinos in Cancer Research
Chapter 9. Optimizing Engagement of the Latino Community in Cancer Research
Part VII. Emerging Policies Impacting Latino Care
Chapter 10. Latino Population Growth and the Changing Demography of Cancer
Chapter 11. Financial Hardship, Food Insecurity, and Forgone Medical Care
Part VIII. Implementation Science, Innovative Technologies and the Future of Cancer Care
Chapter 12. Implementation Science to Enhance the Value of Cancer Research in Latinos: A Perspective from the National Cancer Institute
Chapter 13. Advancing E-health Interventions in Cancer Control and Survivorship for Hispanic/Latina Breast Cancer Patients
Part IX. Latino Lifestyles: Acculturation, Nutrition, and Health
Chapter 14. Impact of Obesity and Related Factors in Breast Cancer Survivorship Among Hispanic Women
Chapter 15. A Strength-Based Approach to Cancer Prevention in Latinxs
Part X. Advances in Cancer Therapy and Clinical Trials
Chapter 16. Overcoming Clinical Research Disparities by Advancing Inclusive Research
Part XI. HPV Vaccination for Cancer Prevention
Chapter 17. The Road to Cervical Cancer Elimination
Part XII. Latino Cancer Health Disparities: Moving Forward
Chapter 18. Looking Forward: Continuing the Collaboration for Action
Appendices A-D
Index.

Summary: The entire world is in crisis with adverse childhood experiences (ACEs) and other lifetime trauma at an all-time high. This book is a valuable resource to promote optimal brain function for everyone, but especially for survivors of trauma who are particularly at risk throughout the life course. It is critical for healthcare providers, schoolteachers and administration, public safety professionals, foster and adoptive parents, employers and loved ones to understand the potential life-long consequences that ACEs can have in the lives of survivors. This book describes the complexities behind why behaviors occur if hurt people hurt themselves and others. The first half of this book addresses what can go wrong in the brain and body after trauma that potentially leads to life-long poor bio-behavioral health outcomes. The second half of this book addresses how the life-long poor bio-behavioral health outcomes can be prevented, mitigated or potentially reversed. This book is necessary for everyone who is interested in optimizing brain function, especially survivors of ACEs and other trauma throughout the life course who are at greater risk. The major focus of the book is on how to prevent long-term negative consequences of trauma and how to restore the brain, body, behavior and emotions.

Contents:
Intro
Foreword by Ann Wolbert Burgess
Foreword by Christina D. Spink
Foreword by Harold G. Koenig
Preface
Contents
About the Book
About the Author
Part I: Overview of Adverse Traumatic Experiences
1: Introduction, Epidemiology, Measurement, and the Cycle of Trauma
Epidemiology of Adverse Childhood Experiences (ACEs)
The Cost of ACEs
Measurement of Adverse Childhood Experiences (ACEs)
Healthy Stress Versus Toxic Stress
Intergenerational and Other Cycles of Trauma: Hurt People May Hurt Themselves and Others
Epigenetics
Conclusion
Resources Suicide Resources
References
Part II: The Potential Serious Nature of Adverse Childhood Experiences
2: Adverse Childhood Experiences and Neurodevelopment
Mental Health Conditions
Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD)
Post-traumatic Stress Disorder (PTSD)
Bipolar Affective Disorder (BP) and Schizophrenia (SZ)
Intrauterine Environment
Exposure to Alcohol and Other Substances
Maternal Health and the Developing Child
Summary and Conclusion
Resources
References 3: Potential Lifelong Neurobiological, Bio-behavioral, and Other Outcomes of Trauma
Post-traumatic Stress Disorder (PTSD)
Complex Trauma
High-Risk Behaviors: Lack of Regard for Self and Others
Lifestyle, Mental and Physical Outcomes
Obesity, Type 2 Diabetes, and Related Health Conditions
Risky Sexual Behavior and Sexually Transmitted Diseases
Substance Use
Other Eating Disorders
The Impact of COVID-19 Trauma on Diet and Weight
Relationships
Criminal Behavior
Antisocial Personality Disorder
Homelessness
Summary and Conclusion
Resources Suicide Resources
Eating Disorder Resources
References
Part III: The Potential Impact of Trauma on the Brain, Body, Behavior and Society
4: Childhood Physical Abuse (CPA), Childhood Sexual Abuse (CSA), Abusive Traumatic Brain Injury (TBI), Childhood Emotional Abuse (CEA), Neglect, and Other Trauma
Individual Risk Factors
Family Risk Factors
Community Risk Factors
Childhood Physical Abuse
Abusive Traumatic Brain Injuries (TBI)
Long-Term Outcomes
Childhood Sexual Abuse (CSA) and Other Sexual Trauma
Neurobiology of the Normal Stress Response Potential Lifelong Hypothalamic-Pituitary-Adrenal (HPA) Axis and Stress System Changes After ACEs
Implications of Stress Systems Changes on Bio-behavioral Health Outcomes
Childhood Emotional Abuse (CEA), Neglect, and Poverty
Human Trafficking
Secondary Vicarious Trauma
Summary, Conclusions, and Recommendations
Resources
Suicide Resources
Vicarious Trauma Resources
References
5: Absence of a Healthy Parent: Mental and Physical Illness, Substance Misuse, and Trauma in the Life of Parents, Caregivers, and Significant Others
Mental Health Conditions

Summary: This book describes adverse cutaneous drug reactions as among the most frequent events in patients receiving drug therapy. Cardiovascular drugs are an important group as there are a greater number of indications for the use of new drugs and their prescription continues to increase. The exact incidence of cutaneous side effects from cardiovascular drugs is difficult to estimate due to sporadic reporting. Moreover, a reliable connection between a certain drug and a certain type of reaction can only rarely be made, aside from the well-known angioedema/urticaria from angiotensin-converting enzyme inhibitors, lichen planus/lichenoid reaction from beta adrenergic blockers, and photosensitivity from thiazid diuretics. These reactions can extend to rare but life-threatening conditions such as erythroderma, Stevens-Johnson syndrome, toxic epidermal necrolysis and drug hypersensitivity syndrome. Adverse Cutaneous Drug Reactions To Cardiovascular Drugs reviews the reported types of reactions to cardiovascular drugs. Each is discussed according to drug class and the type of dermatologic reaction with special emphasize on cross-reactions and the role of patch testing in diagnosis. A total of 116 images are included featuring clinical appearance of common adverse cutaneous drug reactions and diagnostic procedures such as patch and photopatch testing with the suspected drugs. Complementary tables may allow to scan the most common cutaneous reactions and the related cardiovascular drugs along with the possible cross reactions at first glance. It will thus be of considerable importance to all dermatologists and medical professionals who manage the skin, while being an important reference resource for cardiologists in terms of identifying potential adverse reactions to the drugs they prescribe.

Contents:
Introduction (General information on different types of ACDR)
Angiotensin converting enzyme inhibitors
Angiotensin II receptor blockers
Alpha-2 adrenergic receptor agonists
Alpha-adrenergic receptor blockers
Adrenergic neuron blockers
Class I antiarrhythmic drugs (sodium channel blockers)
Beta adrenergic receptor blockers (class II antiarrhythmics)
Class III antiarrhythmics
Calcium channel blockers (class IV antiarrhythmics)
Diuretics
Sympathomimetics
Vasodilatory drugs
Lipid lowering drugs
Platelet inhibitors
Thrombolytics
Anticoagulants
Miscellaneous drugs
Diagnostic procedure: The role of patch. .

Summary: Bio-nano interactions / Dana Westmeier, Shirley K. Knauer, Roland H. Stauber, Dominic Docter -- Physicochemical characterization / Kristen Rasmussen, Hubert Rauscher, Agnieszka Mech -- Toxicity tests / Maria Dusinska, Elise Rundén-Pran, Jürgen Schnekenburger, Jun Kanno -- Computational approaches / Tu C. Le, Vidana Epa, Lang Tran, Dave Winkler -- Exposure Assessment / Kai Savolainen, Antonio Pietroiusti -- Biomonitoring / Enrico Bergamaschi, Irirna Guseva Canu, Adriele Prina-Mello, Regulation and legislation / Kirsten Rasmussen, Brigit Sokull-Klüttgen, IL Je Yu, Jun Kanno, Akihiro Hirose, Maureen R. Gwinn -- Risk assessment and risk management / Robert Landsiedel, Ursula G. Sauer, Wim H De Jong -- Respiratory system, part one / Craig A. Plooand, Ken Donaldson -- Respiratory system, part two / Harri Alenius, Michael R. Shurin, Galina V. Shurin, Don Beezhold, Anna A. Shvedova -- Cardiovascular system / Jennifer B. Raftis, Nicholas L. Mills, Rodger Duffin -- Neurological system / Myrtill Simkó, Mats-olof Mattsson, Robert A. Yokel -- Immune system / Diana Boraschi, Bengt Fadeel, Albert Duschl -- Endorine system / Xuefei Lu, Yong Zhu, Tao Zhu -- Skin / Nancy A. Monteiro-Riviere, Francesca Larese Filon -- Gastrointestinal system / Mark A. Jepson, Hans Bouwmeester -- Reproduction and development / Luisa Campagnolo, Karin S. Hougard -- Genotoxicitiy and cancer / Shareen H. Doak, Ying Liu, Chunying Chen.

Contents:
Introduction
Kinases
Kinase inhibitors
Adverse events
Imantinib
Gefitinib
Erlotinib
Sorafenib
Sunitinib
Dasatinib
Lapatinib
Nilotinib
Pazopanib
Vandetanib
Vemurafenib
Crizotinib
Ruxolitinib
Axitinib
Bosutinib
Regorafenib
Cabozantinib
Ponatinib
Dabrafenib
Trametinib
Afatinib
Idelaisib
Ibrutinib
Overview
Conclusion and perspectives.

Summary: This monograph gathers and evaluates data on adverse events (AEs) associated specifically with those 'biomedicines' - monoclonal antibodies, fusion proteins, and cytokines - that have recently entered therapeutic use in humans. All AEs observed when using each member of this new drug class are covered, with a view to improving understanding of pathogenesis, facilitating prevention, monitoring, and control, and contributing to the development of better drugs that provide benefits while minimizing risk. Further aspects here examined include the role of drug mechanisms of action and immunogenicity in relation to AEs outcome and induction of systemic syndromes. Additional data on AEs in off-label treatments are also considered. Electronic data sheets, downloadable from the Springer Extra Materials platform, include more detailed safety data as well as additional basic information on product characteristics, pre- and post-marketing AEs classified according to frequency, and system/organ targeting. Data on excipients and selected information on drug interactions and associations are also provided. Adverse Events with Biomedicines: Prevention Through Understanding will serve as a detailed, practical guideline to this important new area, which demands the attention of clinicians, immunologists, oncologists, allergologists, public health professionals, and drug companies.

Contents:
Part I. General Aspects: 1 Introduction
2 Adverse drug events to biomedicines
3 Systemic syndromes caused by biomedicines
Part II. Monoclonal antibodies: 4 Monoclonal antibodies
5 Abciximab
6 Adalimumab
7 Alemtuzumab
8 Basiliximab
9 Belimumab
10 Bevacizumab
11 Brentuximab
12 Canakinumab
13 Catumaxomab
14. Certolizumab
15 Cetuximab
16 Daclizumab
17 Denosumab
18 Eculizumab
19 Edrecolomab
20 Efalizumab
21 Gemtuzumab
22 Golimumab
23 Ibritumomab
24 Infliximab
25 Ipilimumab
26 Muromonab
27 Natalizumab
28 Nimotuzumab
29 Ofatumumab
30 Omalizumab
31 Palivizumab
32 Panitumumab
33 Pertuzumab
34 Ranibizumab
35 Rituximab
36 Tocilizumab
37 Tositumomab
38 Trastuzumab
39 Ustekinumab
Part III Fusion proteins: 40 Fusion proteins
41 Abatacept
42 Aflibercept
43 Alefacept
44 Belatacept
45 Etanercept
46 Rilonacept
47 Romiplostim
Part IV Cytokines : 48 Cytokines
49 Interleukins
50 Denileukin-diftitox
51 Anakinra
52 Interferons
53 Hemopoietic stimulatory factors
54 Myelopoietic stimulatory factors
55 Thrombopoietic stimulatory factor
56 Pluripotent growth factors
57 Epidermal growth factors
Part V Overview: 58 Biomedicines as adverse event inducers
59 Conclusions and perspectives.

Contents:
Adverse reactions to biologics in psoriasis / Lockwood, S.J., Prens, L.M.; Kimball, A.B.
Clinical trial and registry data / Gooderham, M., Papp, K.
Immunosuppression/infections across indications / Al-Khalili, A., Dutz, J.P.
The immunogenicity of biologic therapies / Garcias, S., Demengeot, J.
Paradoxical reaction S : anti-tumor necrosis factor alpha agents, Ustekinumab, Secukinumab, Ixekizumab, and others / Puig, L.
Bullous diseases / Corbaux, C., Joly, P.
Adverse reactions of antibody-therapy for primary cutaneous lymphomas : Rituximab, Brentuximab vedotin, Alemtuzumab, and Mogamulizumab / Saulite, I., Guenova, E., Hoetzenecker, W.
Adverse reactions to biologics : melanoma (Ipilimumab, Nivolumab, Pembrolizumab) / Hwang, S.J.E., Fernández-Peñas, P.
Skin manifestations of targeted antineoplastic therapy / Sanmartín, O.

Summary: This book describes the biochemistry and genetics of aerobic degradation of hydrocarbons and lipids by bacteria and yeasts, as well as the functional genomics of the best-known microorganisms involved in these processes. It forms part of the Handbook of Hydrocarbon and Lipid Microbiology Series, a definitive resource of current knowledge on the diverse aspects of the interactions of microbes with hydrocarbons and lipids. Chapters are mainly focused on the new discoveries of recent years. It is aimed to scientists and others interested in different aspects of the microbiology of hydrocarbons.

Contents:
A Genomic View of the Catabolism of Aromatic Compounds in Pseudomonas
A Genomic View of the Catabolism of Short Chain Alkanes
Aerobic Degradation of Aromatic Hydrocarbons
Aerobic Degradation of Aromatic Hydrocarbons: Enzyme Structures and Catalytic Mechanisms
Aerobic Degradation of Chloroaromatics
Aerobic Degradation of Gasoline Ether Oxygenates
Aerobic Degradation of Halogenated Aliphatics
Biochemistry and Molecular Biology of Methane Monooxygenase
Biosynthesis, Insertion and Function of Fe-S Cofactors
Biosynthesis, Insertion and Function of Flavin Cofactors
Biosynthesis, Insertion and Function of haem-iron Prosthetic Groups
Computational Framework for Integration of Lipidomics Data into Metabolic Pathways
Degradation of Dimethylsulfoniopropionate (DMSP) and Dimethylsulfide (DMS)
Degradation of Rubber/Polyisoprene
Diversity and Common Principles in Enzymatic Activation of Hydrocarbons: An Introduction
Energetic and Other Quantitative Aspects of Microbial Hydrocarbon Utilization: An Introduction:
Enzymes for Aerobic Degradation of Alkanes in Bacteria
Enzymes for Aerobic Degradation of Alkanes in Yeasts
Evolution of New Catabolic Functions Through Gene Assembly by Mobile Genetic Elements
Experimental Evolution of Novel Regulatory Activities in Response to Hydrocarbons and Related Chemicals
Functional Gene Diversity, Biogeography, Dynamics
Genetic Features and Regulation of n-Alkane Metabolism in Bacteria
Genetic Features and Regulation of n-Alkane Metabolism in Yeasts
Genetic Features of Methylotrophs
Genetics and Functional Genomics of Aerobic Degradation of Hydrocarbons: An Introduction
Genetics and Molecular Features of Bacterial Dimethylsulfoniopropionate (DMSP) and Dimethylsulfide (DMS) Transformations
Genetics of Biphenyl Biodegradation and Co-Metabolism of PCBs
Genetics of Rubber/Polyisoprene Degradation
Genetics and Ecology of Isoprene Degradation
Genomic View of Mycobacterial High Molecular Weight Polycyclic Aromatic Hydrocarbon Degradation
Global Aerobic Degradation of Hydrocarbons in Aquatic Systems
Global Aerobic Degradation of Hydrocarbons in Terrestrial Systems
Global Consequences of the Microbial Production and Consumption of Inorganic and Organic Sulfur Compounds
Key Features of Aerobic Hydrocarbon Biodegrader Genomes
Lipid Degradation
Lipid Cycles
Lipolytic Enzymes from Bacteria
Lipolytic Enzymes from Yeasts
Metabolism of Steroids
Oxidative Inactivation of Ring-Cleavage Extradiol Dioxygenases: Mechanism and Ferredoxin-Mediated Reactivation
Pathways for the Degradation of Fatty Acids in Bacteria
Phylogenomics of Aerobic Bacterial Degradation of Aromatics
Physiology and Biochemistry of the Aerobic Methane Oxidizing Bacteria
Potential for Microbial Interventions to Reduce Global Warming
Rational Construction of Bacterial Strains with New/Improved Catabolic Capabilities for the Efficient Breakdown of Environmental Pollutants
Regulation of the Degradation of Fatty Acids in Bacteria
Regulation of the Degradation of Fatty Acids in Yeast
Stereochemistry of Hydrocarbon-transforming Enzyme Reactions
Structure-Function Relationships and Engineering of Haloalkane Dehalogenases
Transcriptional Control of the TOL Plasmid Pathways.

Summary: Now in its fully revised and expanded second edition, this volume is the definitive resource on long-distance air transport of injured patients in both peacetime and wartime. It discusses the history of aeromedical evacuation, triage and staging of the injured patient, evacuation from site of injury to medical facility, air-frame capabilities, medical capabilities in- flight, response to in-flight emergencies, and mass emergency evacuation. Specific medical conditions are addressed in detail in the second half of the book, including general surgical casualties such as abdominal wounds and soft tissue injuries, vascular injuries, maxillofacial injuries, head and spinal cord injuries, ophthalmologic casualties, orthopedic casualties, burns, pediatric casualties, obstetric-gynecologic casualties, and more. For each medical condition, important topics are addressed such as conditions needed to be met before transportation, special concerns, supplies and needs of the specific patients and possible in-flight emergencies and their appropriated treatment. Containing several new chapters and featuring extensively updated contributions from experts in the field, Aeromedical Evacuation: Management of the Acute and Stabilized Patient, Second Edition is a must-have reference for a whole new generation of military flight surgeons and flight nurses responsible for aeromedical evacuation of casualties as well as civilian physicians and nurses involved in air transport of ill and post-operative patients. .

Contents:
Introduction
Aeromedical Evacuation: A Historical Perspective
Military Casualty Evacuation: MEDEVAC
Civilian Air Medical Transport
Aircraft Considerations for Aeromedical Evacuation
Preparation for Long-Distance Aeromedical Evacuation
Aeromedical Patient Staging
Military Aeromedical Evacuation Nursing
Critical-Care Air Transport: Patient Flight Physiology and Organizational Considerations
Aeromedical Evacuation of Patients with Abdominal, Genitourinary, and Soft Tissue Injuries
Orthopedic Patients
Aeromedical Evacuation of the Neurosurgical Patient
Otorhinolaryngology Head and Neck Surgery Patients
Care of Ophthalmic Casualties
Peripheral Vascular Casualties
Aeromedical Evacuation of Cardiothoracic Casualties
Burn Casualties
Patients Requiring Mechanical Ventilation
Medical Casualties
Aeromedical Evacuation of Patients with Contagious Infections
Aeromedical Evacuation of Obstetric and Gynecological Patients
Overview of Pediatric and Neonatal Transport
Aeromedical Evacuation of Psychiatric Casualties.

Contents:
Introduction
Anatomy and Function
The?Perfect Look?
Indications
Labia minora: Planning the Procedure
Surgical Techniques
Pitfalls & Complications
Aftercare. Labia majora: Planning the Procedure
Surgical Technique
Pitfalls & Complications
Aftercare
Before surgery
Aftercare
Consent
FAQs.

Summary: Aesthetic or cosmetic gynecology is a rapidly expanding and much in demand field worldwide. This book covers all aspects of cosmetic gynecology in great details and interdisciplinary fields. It provides information and practical tips on the new evolving and fast growing branch of aesthetic and regenerative gynecology. The book covers basics along with illustrations, practical tips and troubleshooting points. Chapters include anatomy, physiology, pathology and comprehensive management of diseases in relation to cosmetic gynecology. The book explains the basics of techniques and devices used in this field such as several energy based and high tech devices like lasers, Hifu, HIFEM, their safety profile, scope and uses in an easy to understand language supported by illustrations. It also covers complications, controversies and medicolegal issues surrounding this field. The book includes chapters from national and international experts of each technique and helps in systematic evidence based learning. The book serves as a comprehensive book for postgraduates and consultants in gynecology, plastic surgery, dermatology, urogynecology, vascular surgery, general surgery, for cosmetologists and those interested in regenerative sciences.

Contents:
Introduction to rising field of aesthetic and regenerative gynecology
Epidemiological perspective in aesthetic and regenerative gynecology
Anatomy and physiology in relation to aesthetic and regenerative gynecology
Counselling your patient of aesthetic and regenerative gynecology
Medicolegal aspects in aesthetic and regenerative gynecology
Invasive and non-invasive procedures in aesthetic and regenerative gynecology
Energy based devices - comparisons and indications
Lasers in aesthetic and regenerative gynecology - physics, types, applications, safety profiles
Laser in vaginal rejuvenation
Erbium laser in aesthetic and regenerative gynecology
Management of urinary incontinence in aesthetic and regenerative gynecology
Non-cosmetic uses of laser in aesthetic and regenerative gynecology - vulvodynia, incontinence, infections, warts
Genitourinary syndrome of menopause
Radiofrequency in aesthetic and regenerative gynecology
Carboxytherapy in aesthetic and regenerative gynecology
High intensity focused ultrasound (HIFU) in aesthetic and regenerative gynecology
High intensity focused electronic-magnetic technology (HIFEM) in aesthetic and regenerative gynecology
LED therapy in aesthetic and regenerative gynecology
Sexual rejuvenation in aesthetic and regenerative gynecology
Non-invasive treatment of varicose veins in aesthetic and regenerative gynecology
Hymenoplasty, vaginoplasty and perineoplasty in aesthetic and regenerative gynecology
Labiaplasty and cliteroplasty in aesthetic and regenerative gynecology
Butt and thigh reshaping in aesthetic and regenerative gynecology
Nanofat grafting in aesthetic and regenerative gynecology
Abdominoplasty in aesthetic and regenerative gynecology
Breast lifting and reduction in aesthetic and regenerative gynecology
Thread lift in aesthetic and regenerative gynecology
Hypo pigmentations and hyper pigmentation of face and genital area
Chemical peels and vulval whitening in aesthetic and regenerative gynecology
Scars in aesthetic and regenerative (especial reference to acne and stretch marks) gynecology
Hair transplant and hair removal in aesthetic and regenerative gynecology
Gender reassignment surgery in aesthetic and regenerative gynecology
Injectables in aesthetic and regenerative gynecology
HA for bio remodeling
Platelet rich plasma (PRP) in aesthetic and regenerative gynecology
Role of amniotic fluid in aesthetic and regenerative gynecology
Role of exosomes in aesthetic and regenerative gynecology
Stem cell therapy in aesthetic and regenerative gynecology
Anesthesia in procedures of aesthetic and regenerative gynecology
Cool sculpting in aesthetic and regenerative gynecology
Future of aesthetic and regenerative gynecology.

Summary: With coverage ranging from skin anatomy to patient selection, safety to complications, this book offers complete coverage of Intense Pulsed Light (IPL) treatments. It includes numerous illustrations, tables and color pictures.

Contents:
Skin anatomy
Light-tissue interaction
IPL safety: legal issue
Patient selection
Office-based anesthesia for IPL
Facial skin rejuvenation with IPL
IPL hair removal
IPL for stria distensae
IPL for acne vulgaris
IPL for rosacea
IPL for telangiectasia and reticular veins
IPL for portwine stain
IPL for pigmented lesions
IPL for scars
Recommendations after IPL treatment
Other IPL applications.

Summary: This book deals with the management of difficult breast augmentation revision cases. After critically reviewing the complication rate in aesthetic breast augmentation, the authors go on to discuss the importance of the inframammary fold. Moreover, this book provides detailed instructions on how to manage capsular contracture; wrinkling; animation deformity; implant rotation and waterfall deformities; symmastia; implant rupture; infection and implant exposure; double bubble; and bottoming out. Each chapter starts with a short explanation of the complication, followed by step-by-step revision procedures. Checklists, high-quality images, flowcharts and bullet point-like presentations will help surgeons solve these various problems. Well-structured chapters and a concise format make this book a quick reference guide that aids clinicians in making decisions and providing treatment.

Contents:
Aesthetic Breast augmentation complications rate, a critical review
The importance of inframammary fold (IMF) in aesthetic breast augmentation
Capsular contracture
Wrinkling
Animation deformity
Implant rotation and waterfall deformities
Symmastia
Implant rupture
Infection and Implant exposure
Double bubble and bottoming out.

Summary: Platelet rich plasma therapy uses a patient's own platelets to encourage and accelerate healing in a variety of tissues. With the growing popularity of using platelet rich plasma for aesthetic procedures, the need for a book that ties together all of the current literature in one place has become more pressing. This book fills in that gap as a comprehensive guide that covers history, basic science and clinical utility of platelet rich plasma with its uses in hair restoration, facial rejuvenation, and some wound healing. It includes the latest studies/literature from peer reviewed journals and clinical, anecdotal experience. Chapters provide an extensive look at how to describe the mechanism of action of platelet rich plasma (PRP) in the skin and hair; how to identify the difference between PRP, platelet rich fibrin, and stem cells; and identify the various PRP preparation systems and how to calculate dosing. Aesthetic Clinician's Guide to Platelet Rich Plasma is written especially for the aesthetic clinician, whether dermatologist or plastic surgeon. This book will find utility across specialties and with it's extensive coverage it is a vital reference.

Contents:
History of PRP
Basic Science of PRP
Preparation systems
Microneedling + PRP
PRP for hair loss (AGA)
PRP for scarring alopecia
PRP for immune mediated alopecias
Platelet rich fibrin (PRF)
Stem cells.

Summary: Rhytidoplasty is a palliative procedure in which face wrinkles are surgically removed to promote a more youthful appearance. This book, written by leading specialists for Brazil and abroad, discusses a wide variety of topics related to facial rejuvenation. The first sections focus on the surgical planning, including psychological considerations, preparation of the patient and anatomical and biochemical changes caused by the aging process. It also describes the surgical anatomy of the forehead, face, neck and eyelids. The third section provides a comprehensive overview of the basic techniques of facelift with details of refined surgical approaches for each segment of the face and neck. It highlights liposuction techniques, lipoinjection as well as transference of stem cells, showing their importance in reshaping the facial contours. It addresses both the treatment of soft tissue and craniofacial bone structures to improve the aesthetics of the face. The next sections present the final scars after face-lifting, minimally invasive procedures as complementary approaches during rhytidoplasty and the associated procedures during rhytidoplasty. The last section discusses postoperative care. Aesthetic Facial Surgery consists of 64 chapters focusing on all aspects of face lifting, and meticulously describes surgical details not covered in other medical books. Featuring numerous figures, photographs, software and videos, it is a valuable resource for young and experience surgeons alike around the world.

Summary: This comprehensive book covers anatomy, recent techniques, postoperative care, possible complications, and outcomes in aesthetic surgery of the abdomen. The extensive section on aesthetic procedures includes many important innovations in abdominoplasty. Detailed consideration is also given to the various potential complications, with guidance on their prevention, diagnosis, and management. The book is written by acknowledged experts in the topics on which they write. It will be of value for residents and fellows and more experienced surgeons in the fields of plastic surgery, general surgery, cosmetic surgery, and general surgery.

Summary: This book is a resource that offers guidance to nurses who are experienced or novice aesthetic practitioners and would like to improve their aesthetic practice and enhance patient safety and satisfaction. This textbook reviews skin structure and anatomy, what happens as facial structures age, the effects of aging coupled with environmental exposures, pharmacology of medications used in aesthetics, light-based device properties, patient selection, and benefits of treatments. In addition, it includes suggestions on how to communicate with patients to achieve successful outcomes. Aesthetic Procedures: Nurse Practitioner's Guide to Cosmetic Dermatology provides practitioners a one-source resource to attain more in-depth learning about cosmetic dermatology. Although there are several texts on individual aspects of aesthetic medicine, there is no all-inclusive book for nurses. This book affords the primary care practitioner the opportunity to add minimally invasive cosmetic dermatology procedures to their practice and perform the treatments safely, efficiently and effectively while avoiding common mistakes and minimizing complication risks. Education is paramount in creating a safe patient environment and as more clinicians turn to aesthetics to augment their practice, this book will be a valuable resource for nurses and practitioners all over the world.

Contents:
About the Author (Dr. Beth Haney, DNP)
Endorsements
Dedication
Acknowledgements
Important Message to Reader
Foreword
Introduction
SECTION 1: Non-Invasive Treatments
Chapter 1: Fads and Promises
Chapter 2: Skin Anatomy and Physiology
Chapter 3: Overview of Topical Treatments and Prescriptions
SECTION 2: Laser and Light-Based Procedures
Chapter 4: Laser and Light-Based Treatment Overview
Chapter 5: Indications for Laser and Light-Based Treatments (conditions treated)
Chapter 6: Laser and Light-Based Treatments: Patient Selection and Expected Outcomes
SECTION 3: Minimally Invasive Procedures
Neuromodulators
Chapter 7: Neuromodulators; pharmacology of botulinum toxins for cosmetic use
Chapter 8: Indications for Neuromodulators; Upper face
Chapter 9: Indications for Neuromodulators; Lower Face
Chapter 10: Indications for Neuromodulators; Other Uses and Future Possibilities
Chapter 11: Complications and Corrections
SECTION 4: Minimally Invasive Procedures - Dermal Fillers
Chapter 12: Dermal Fillers; pharmacology of various types of dermal fillers for cosmetic use
Chapter 13: Indications and Placement of Dermal Fillers
Chapter 14: Complications and Corrections of Dermal Filler
Section 5: Selected Novel Face and Body Treatments
Chapter 15: Facial Skin Tightening
Chapter 16: Body Shaping
Section 6: Common Skin Conditions Affecting Appearances at Any Age
Chapter 17: Acne in Adolescents and the Over 40 Age Groups
Chapter 18: Menopausal Skin Issues and Remedies
Chapter 19: When to Refer to a Plastic Surgeon
Index.

Contents:
Applied anatomy for safety in facelifting / Dino R. Elyassnia
Facial analysis for facelifting / Michael J. Sundine
Analysis of the neck / Nicholas Nikolov
Facial aging / Bryan G. Forley
Energy-based treatments for facial aging / Lawrence S. Bass and Jason N. Pozner
Facial sculpting and facial slimming with neurotoxins / Woffles T.L. Wu
Soft tissue fillers / Taiba Alrasheed, Paul Schembri, and Trevor M. Born
Years of progression in facelifting and neck lifting / Steven M. Hamilton and Bruce Connell
Male versus female facelift surgery : is there a difference? / Steven M. Hamilton
Foreheadplasty : recognizing and treating aging in the upper face / Bruce Connell
Endoscopic browlift / Scott R. Miller and Ahmad N. Saad
Primary superficial musculoaponeurotic system facelift and neck lift / Michael J. Sundine and Bruce Connell
Submental contouring / Bruce Connell
Simultaneous facelift and fat grafting / Timothy J. Marten and Dino R. Elyassnia
Midface lift / Garo Kassabian
Condition-specific rhytidectomy : an evidence-based paradigm shift in facial rejuvenation / E. Gaylon McCollough and Fred G. Fedok
Secondary facelifting / Michael J. Sundine
Avoiding complications in facelifts / G. Hunt Neurohr
Periorbital rejuvenation with autologous fat / Yifan Guo, Brian C. Drolet, and Patrick K. Sullivan
Comparison of midface rejuvenation techniques / Michael J. Sundine
Upper-eyelid blepharoplasty / Robert Flowers and Christopher Costa
Lower-eyelid blepharoplasty / William P. Chen
Lateral canthal complications in aesthetic eyelid surgery : prevention and reconstruction / M. Douglas Gossman
Treatment of the tear-trough deformity / Ramsey J. Chouchair
Management of the lateral periorbital area / Thomas A.B. Bell.

Summary: This extensively revised second edition describes how techniques previously developed by Dr. Rollin Daniel for use in open rhinoplasty can be adapted for the closed approach. The author argues that this offers greater feedback during surgery, a shorter recovery period and absence of scarring. The book includes a full explanation of preoperative preparation, including evaluation of the nasal surface aesthetics using the concept of geometric polygons as aesthetic subunits to define both the existing deformity and the aesthetic goals. Aided by a wealth of color photos, it also provides step-by-step descriptions of the surgical techniques developed and modified to achieve the desired surface appearance, and illustrates how the novel dissection and redrape control methods reduce the healing time and enhance outcomes. Further, the book presents a series of case analyses documenting the benefits of the approach. Written in a "cookbook style" this superbly illustrated book enables plastic surgeons to quickly learn how to utilize the closed approach to rhinoplasty for optimal aesthetic benefit.

Summary: This book covers all aspects of aesthetic breast surgery in an instructive, step-by-step format. The descriptions of procedures are completely up to date, encompassing newly introduced techniques and recent modifications of established techniques. Individual parts of the book are devoted to breast augmentation, mastopexy, and breast reduction. Detailed consideration is also given to risks and complications, with guidance on their avoidance and the treatment of complications. In addition, anatomy, anesthesia, and a range of miscellaneous procedures applicable in specific circumstances are all well covered. The authors are acknowledged experts in their fields who draw on a wealth of experience in describing and illustrating their personally favored techniques. Aesthetic Surgery of the Breast will be an ideal reference for both students (residents and fellows) and practicing cosmetic, plastic, and general surgeons.

Summary: "Changing trends, ethnic and regional preferences, and a hands-on teaching method make cosmetic surgery uniquely challenging for novice and experienced surgeons alike. Aesthetic Surgery Techniques: A Case-Based Approach offers expert, real-world instruction by presenting chapters and patients in a classical fashion, providing a clinical perspective as you work through case after case, honing your knowledge and skills. A diverse, international group of highly reputable faculty takes you step by step through each case"--Publisher's description.

Contents:
Part 1: Introduction. Informed consent: protecting the patient and the surgeon
Aesthetic medicine - surgical pearls
Aesthetic applications for fillers
Part 2: Head and neck. Section 1: forehead and brow
Brow lift
Endoscopic brow lift made easy
Section 2: Eyes. Upper blepharoplasty
Asian blepharoplasty
Midface descent and malar support
Anatomical relationship of SOOF and ROOF in eyelid rejuvenation
Non-surgical rejuvenation of the periorbital area
Section 3: Facelift. High SMAS facelift
Management of the neck
The turkey neck - surgical management
Platysma bands
Section 4: Rhinoplasty. Prominent nose
Aesthetic nasal tip surgery
Crooked nose
The Middle Eastern- Mediterranean nose
The Oriental rhinoplasty
Male rhinoplasty
Cosmetic dermatology of the nose and medical rhinoplasty
Part 3: Peri oral aesthetics and dentistry. Orthognathic surgery
Implantology
Aesthetic dentistry of the smile line
Part 4: Breast. Small breast
Breast reduction
Mastopexy with mesh for breast ptosis
Simultaneous augmentation and periareolar mastopexy: indications and limitations
Asymmetric breast
Male breast
Part 5: Trunk / abdominal wall. Improving the waistline with the modified Brazilian abdominoplasty
Post-bariatric abdominoplasty
Non-excisional management of the anterior abdominal wall
Body contouring following massive weight loss
Gluteal augmentation
Part 6: Upper and lower extremity. Rejuvenation of the arm
Aesthetic management of the aging hand
Inner thigh lift
Inner thigh reduction: reshaping using a two way vector technique.

Summary: This book schematically discusses the available techniques for aesthetic vaginoplasty, including vagina rejuvenation and other related surgical and non-surgical approaches. By furthering our understanding of the field, it promotes a better surgical practice on aesthetic vaginal surgeries. More specifically, this book will enable surgeons to correctly assess patients, choose and plan procedures, and reproduce the most common surgical aesthetic vaginal procedures. Each chapter is written in a pedagogical way, promoting a direct applicability. For each surgical procedure discussed, it features topics such as consultation and patients intentions, clinical examination, anatomy and important landmarks, surgical technique and possible complications. Aesthetic Vaginal Plastic Surgery: A Practical Guide is intended for any medical professional interested in vagina aesthetic and rejuvenation procedures, especially those in the fields of plastic surgery, gynecology and urology.

Contents:
Part I: Introduction
Chapter 1 Why Genital and Vaginal Rejuvenation
Chapter 2 Challenges When Starting My Vaginal Rejuvenation Practice
Part II: Vaginal Rejuvenation—External Aesthetic Surgical Techniques
Chapter 3 Wedge Labiaplasty
Chapter 4 Lazy S Labiaplasty (Edge Labiaplasty)
Chapter 5 Longitudinal Hoodplasty
Chapter 6 Horseshoe Hoodplasty
Chapter 7 Labiaplasty and Hoodplasty Combined
Chapter 8 Labia Majora Augmentation
Chapter 9 Labia Majora Resection
Chapter 10 Pubic Region
Chapter 11 Hymenoplasty
Part III Vaginal Rejuvenation: Internal Aesthetic Surgical Techniques
Chapter 12 Perineoplasty
Chapter 13 Anterior Vaginoplasty
Chapter 14 Posterior Vaginoplasty
Chapter 15 Combination of Anterior and Posterior Vaginoplasty plus Perineoplasty
Part IV: Vaginal Rejuvenation: Nonsurgical and Beyond
Chapter 16 Labia Majora Non-Surgical Options: Lightening—Fillers—Skin Tightening
Chapter 17 Non-Surgical Vaginal Tightening Procedures
Chapter 18 G Spot Enhancement.

Summary: "Expert guidance on a collaborative approach to mental health care guided by client-driven goals This volume provides fundamental and evidence-based information on working with transgender and gender diverse people in mental health services. The authors, who are experts in the field, outline the key qualities of affirming mental health services, and explore strategies for improving inclusivity and evidence-based care with trans clients. dickey and Puckett also provide insight into current topics, such as working with youth, the harmful and ill-advised approach known as rapid onset gender dysphoria, and whether and how autism might be a co-occurring diagnostic concern. Practitioners will find the printable resources provided are invaluable for their clinical practice, including sample letters of support for trans clients who are seeking gender affirming medical care."-- Provided by publisher.

Contents:
Affirmative Counseling for Transgender and Gender Diverse Clients
Table of Contents
1 Description
2 Theories and Models
3 Assessment and Treatment Indications
4 Treatment
5 Case Vignettes
6 Further Reading
7 References
8 Appendix: Tools and Resources

Contents:
Preface
About the editors
About the contributors
Acknowledgments
Foundations
Developing competence in working with LGBTQI+ communities : awareness, knowledge, skills, and action / Misty M. Ginicola, Joel M. Filmore, and Cheri Smith
The science of gender and affectional orientation / Misty M. Ginicola
Counseling considerations and counseling strategies
Developmental issues for LGBTQI+ people
Growing up LGBTQI+ : the importance of developmental conceptualizations / Anneliese A. Singh, Kristopher M. Goodrich, Amney J. Harper, and Melissa Luke
LGBTQI+ youth development / Melissa Luke, Amney J. Harper, Kristopher M. Goodrich, and Anneliese A. Singh
LGBTQI+ persons in adulthood / Amy Moore-Ramirez, Melanie Kautzman-East, and Misty M. Ginicola
Identity development, coming out, and family adjustment / Kristopher M. Goodrich and Misty M. Ginicola
Physical and mental health challenges found in the LGBTQI+ population / Misty M. Ginicola, Joel M. Filmore, Cheri Smith, and Jahaan Abdullah
Disaffirming therapy : the ascent and descent of sexual orientation change efforts / Peter Finnerty, Michael M. Kocet, Jeff Lutes, and Chad Yates
Evidence based practice for counseling the lgbtqi+ population / Kristopher M. Goodrich and Misty M. Ginicola
Affirmative, strength-based counseling with LGBTQI+ people / Peter Finnerty, Michael M. Kocet, Jeff Lutes, and Chad Yates
Specialized populations
Counseling lesbian clients / Cindy Anderton and Lindsay Woodbridge
Counseling gay male clients / Misty M. Ginicola, Sam Sanabria, Joel M. Filmore, and Michael DeVoll
Counseling bisexual/pansexual/polysexual clients / Misty M. Ginicola and Amney J. Harper
Counseling transgender clients / Robyn Brammer and Misty M. Ginicola
Counseling queer and genderqueer clients / Jeffry Moe, Jamie Bower, and Madeline Clark
Counseling clients questioning their affectional orientation / Jared S. Rose and Eric R. Baltrinic
Counseling intersex clients / Misty M. Ginicola
Counseling asexual clients / Misty M. Ginicola and Angela Ruggiero
Counseling two-spirit clients / Misty M. Ginicola
Emerging issues
Role of ethnicity
Counseling a LGBTQI+ person of color / Joel M. Filmore and Misty M. Ginicola
Counseling LGBTQI+ immigrants / David Barreto, Amy Moore-Ramirez, Melanie Kautzman-East, and Ryan Liberati
Role of religion
The role of religion and spirituality in counseling the LGBTQI+ client / Misty M. Ginicola, Brett H. Furth and Cheri Smith
The grace model of counseling : navigating intersections of affectional orientation and Christian spirituality / R. Lewis Bozard, Jr., and Cody J. Sanders
Working with LGBTQI+ clients who have experienced religious and spiritual abuse using a trauma informed approach / Misty M. Ginicola, Joel M. Filmore, and Michael Stokes
Counselor advocacy
Becoming an ally : personal, clinical, and school-based social justice interventions / Diane Estrada, Anneliese A. Singh, and Amney J. Harper
Glossary of terms.

Summary: This unique resource offers an in-depth, comprehensive look at different types of mental health needs of transgender and gender diverse youth, how these intersect with gender identity, gender expression, and sexual orientation, and provides practical information on how to ethically, responsibly, and sensitively care for these patients. Affirmative Mental Health Care for Transgender and Gender Diverse Youth: A Clinical Guide begins with three introductory chapters which contain practical information regarding assessment, psychological interventions, and the potential medical and surgical interventions that are indicated for youth with gender identity concerns. The remaining chapters are illustrated by multiple cases build around overarching chapter themes. Each case chapter opens with broad questions applicable to clinical practices, while the cases themselves focus on a particular co-occuring mental health condition. The case chapters are structured with intersectionality in mind, including elements of ethnic, racial, and cultural diversity, and the patients range over the full developmental spectrum, from pre-pubertal children to older adolescents. Chapter cases range in complexity as well, to provide readers with the tools they need to evaluate patients, and to assist in the decision of which presenting factors to prioritize in treatment at which time. Ending each chapter are clinical take-home messages, closing with additional practical knowledge that can be applied to other cases providers may see in their own practices. Written by expert clinicians in the field, Affirmative Mental Health Care for Transgender and Gender Diverse Youth: A Clinical Guide is an ideal resource not only for child and adolescent psychiatrists, but for clinicians across all mental health disciplines working with gender non-conforming youth, and who are interested in providing informed, affirmative, and intersectional care.

Contents:
Chapter 1. Affirming and Gender-Informed Assessment of Gender Diverse and/or Transgender Youth Across Development
Chapter 2. Social Gender Transition and the Psychological Interventions
Chapter 3. Transgender Adolescents and the Gender Affirming Interventions: Pubertal Suppression, Hormones, Surgery, and Other Pharmacological Interventions
Chapter 4. Gender Dysphoria and Family Dynamics, and Culture: A Case Composite
Chapter 5. The Gender Nonbinary Adolescent
Chapter 6. "I'm Here to Get Taller and Because I Want to be a Boy": A Case of Down-Turner Mosaicism in a Prepubescent Gender-Nonconforming Child
Chapter 7. Pre-pubertal Children with Gender Dysphoria: A Case to Illustrate the Management of Co-Occurring Attention Deficit Hyperactivity Disorder and Disruptive Behavior Disorders
Chapter 8. Gender Dysphoria and Autism Spectrum Disorders
Chapter 9. Anxiety and Gender Dysphoria
Chapter 10. Childhood Gender Nonconformity and Trauma Recovery in a Transgender Latina: A Retrospective Case Example
Chapter 11. Depression and Gender Dysphoria
Chapter 12. Gender Dysphoria and Psychotic Spectrum Disorders
Chapter 13. Gender Dysphoria and Multiple Co-Occurring Psychiatric Issues: Compare and Contrast.

Summary: This book examines the landmark 2010 Patient Protection and Affordable Care Act (ACA) from the perspective that health policy innovation is translational research directed at improving health. It delineates a new perspective about the creation and potential impact of the ACA and guides the development of health policy that is supported by best evidence that, in turn, transforms into practice, policy, and public benefit. Told by those involved in the creation and implementation of the ACA, the book reviews the history and impact of this ground-breaking legislation and recommends priorities, objectives, and next steps for translational research as the ACA is implemented. Featuring contributions from nationally renowned leaders in healthcare policy, this book adds to the public conversation about the ACA and its role in shaping health policy and contributes to a more realistic, nuanced, and productive understanding of this ground-breaking legislation by physicians, policy makers, and the public. It also provides a framework for next steps in continuing to improve U.S. health policy.

Contents:
Introduction: The Affordable Care Act as a National Experiment
Objectives of the ACA
Delivering on the Promise of the Affordable Care Act
What We Got (and What Might Have Been): A Distinctively American Approach
Commentary to Section II: Conducting the Experiment
The Affordable Care Act as an Experiment: Data We Have, Expect to Have, and Should Have, from a Vermont Pilot Study
The Center for Medicare and Medicaid Innovation: Its Purpose, Processes, and Desired Outcomes
The Dream of a National Health Information Technology Infrastructure
Results from a Massachusetts Pilot Study
Commentary to Section III: Engaging the Public
The Value Proposition for Individuals and the Public
Messaging, Medicine, and Obamacare
Commentary to Section IV: From Personal to Political to Policy: What Next?
Supreme Court Review of the ACA and Political Gamesmanship
Medicaid Expansion Challenges States
Next Experiments in ACA Legislation and Policy
Epilogue.

Summary: The harvesting, processing and consumption of edible insects is one of the main keys to the sustainability of food chains on the African continent. Insects are the largest and most successful group of animals on the planet and it is estimated that they comprise 80% of all animals. This makes edible insects extremely important to the future survival of large populations across Africa and the world. Insects offer a complete animal protein that includes all 9 essential amino acids and are very competitive with other protein sources. They are also a good source of beneficial unsaturated fats, and many insects have a perfect Omega 3:6 balance. African Edible Insects As Alternative Source of Food, Oil, Protein and Bioactive Components comprehensively outlines the importance of edible insects as food and animal feed and the processing of insects in Africa. The text also highlights indigenous knowledge of edible insects and shows the composition and nutritional value of these insects, plus presents reviews of current research and developments in this rapidly expanding field. All of the main types of edible insects are covered, including their nutritional value, chemical makeup, and harvesting and processing details. The various preparation technologies are covered for each insect, as are their individual sensory qualities and safety aspects. A key aspect of this work is its focus on the role of insects in edible oils and gelatins. Individual chapters focus on entomophagy in Africa and the various key aspects of the continent's growing edible insect consumption market. As it becomes increasingly clear that the consumption of insects will play a major role in the sustainability of food chains in Africa, this work can be used as a comprehensive and up-to-date singular source for researchers looking for a complete overview on this crucial topic.

Contents:
Importance of Insects as Food in Africa
African Edible Insect Consumption Market
Entomophagy In Africa
Microbiology of African Edible Insects
The food safety of edible insects
Interdisciplinary Uses of Some Edible Species
Sensory Quality of Edible Insects
Automation of Insect Mass Rearing and Processing Technologies of Mealworms
The legislative status of edible insects in the world
Sorghum bug (Agonoscelis pubescens) as a source of edible oil, protein and gelatin
Watermelon bug (Aspongopus viduatus) as a source of edible oil, protein and gelatin
The Nutritional Composition of African Edible Acridians (Grasshoppers)
Nutrient Composition of Black Soldier Fly, Hermetia illucens
Production, Nutrient Composition and Bioactive Components of Crickets (Gryllidae) for Human Nutrition
Nutrient composition and bioactive components of ants Oecophylla smaragdina Fabricius
Nutrient Composition and Bioactive Components of the Migratory Locust (Locusta migratoria)
Nutrient composition and bioactive components of Mopane worm (Gonimbrasia belina)
Nutrient composition of desert locust (Schistocerca gregaria)
Nutritional Value of Brood and Adult Workers of The Asia Honeybee Species Apis cerana and Apis dorsata
Nutrient composition of Mealworm (Tenebrio molitor)
Nutrient composition of Termites Adepoju, Oladejo Thomas
Ethiopian Termites in the Human Diet: an Investigation into their nutritional profile
Index.

Summary: "Nadia Owusu grew up all over the world--from Rome and London to Dar-es-Salaam and Kampala. When her mother abandoned her when she was two years old, the rejection caused Nadia to be confused about her identity. Even after her father died when she was thirteen and she was raised by her stepmother, she was unable to come to terms with who she was since she still felt motherless and alone. When Nadia went to university in America when she was eighteen she still felt as if she had so many competing personas that she couldn't keep track of them all without cracking under the pressure of trying to hold herself together. A powerful coming-of-age story that explores timely and universal themes of identity, Aftershocks follows Nadia's life as she hauls herself out of the wreckage and begins to understand that the only ground firm enough to count on is the one she writes into existence"-- Provided by publisher.

Contents:
First earthquake
Resettlement registration form
Foreshocks
The blue chair
Topography
The blue chair
Faults
Mainshocks
Faults
The blue chair
Aftershocks
Mainshocks
The blue chair
Terraforming.

Summary: Since the first edition of this book was published in 2004, to much acclaim, the pace of innovation in the field of skin metrology has increased and various new technologies have become available. This new, revised edition of Measuring the Skin reflects these advances by presenting the current theory and practice of noninvasive investigation and measurement of the skin and its appendices in health and disease. The first, extensive part of the book is devoted to the physiology and metrology of the various structural components of the skin. Skin functions and their measurement are then discussed in detail, with sections on mechanical protection, photoprotection, barrier function, immune function, thermoregulation, and sensory function. In addition, careful consideration is given to skin disease rating and skin maps, and a unique list of physical and biological constants and units is provided. Not only is Measuring the Skin the first comprehensive, practical handbook in this domain - it will also serve as a manual of skin physiology and collates anatomical, functional, and physical quantitative data that would otherwise be arduous to retrieve because of their dispersal throughout the literature. It will prove a valuable resource for dermatologists, cosmetologists, bioengineers, physiologists, pharmacists, and all others who deal with the skin in their work.

Contents:
Skin Structural Components
Physiology and Metrology: Skin Surface. Epidermis. Dermis. Epidermal Appendages. Skin Vasculature. Subcutis
Skin Functions and their Measurement: Mechanical Protection. Photoprotection. Barrier Function. Immune Function. Thermoregulation. Sensory Function
Skin Maps
Skin Disease Rating
Skin Constants
Physical Units
Appendix
Subject Index.

Summary: Since the first edition of this book was published in 2004, to much acclaim, the pace of innovation in the field of skin metrology has increased and various new technologies have become available. This new, revised edition reflects these advances by presenting the current theory and practice of noninvasive investigation and measurement of the skin and its appendices in health and disease. The first, extensive part of this authoritative work is devoted to the physiology and metrology of the various structural components of the skin. Skin functions and their measurement are then discussed in detail, with sections on mechanical protection, photoprotection, barrier function, immune function, thermoregulation, and sensory function. In addition, careful consideration is given to skin disease rating and skin maps, and a unique list of physical and biological constants and units is provided. Not only is this new edition the first comprehensive, practical handbook in this domain – it will also serve as a manual of skin physiology and collates anatomical, functional, and physical quantitative data that would otherwise be arduous to retrieve because of their dispersal throughout the literature. It will prove a valuable resource for dermatologists, cosmetologists, bioengineers, physiologists, pharmacists, and all others who deal with the skin in their work.

Contents:
Skin Structural Components
Physiology and Metrology: Skin Surface. Epidermis. Dermis. Epidermal Appendages. Skin Vasculature. Subcutis
Skin Functions and their Measurement: Mechanical Protection. Photoprotection. Barrier Function. Immune Function. Thermoregulation. Sensory Function
Skin Maps
Skin Disease Rating
Skin Constants
Physical Units
Appendix
Subject Index.

Summary: "This first-of-its-kind text provides a multidisciplinary overview of a significant problem in hospital-based healthcare: patients who decline inpatient medical care and leave the hospital against medical advice (AMA). Compared to standard hospital discharges, AMA discharges are associated with worse health and health services outcomes. Patients discharged AMA have been found to have disproportionately higher rates of substance use, psychiatric illness, and report stigmatization and reduced access to care. By providing a far reaching examination of AMA discharges for a wide academic and clinical audience, the book serves as a reference for clinical care, research, and the development of professional guidelines and institutional policy. The book provides both a broad overview of AMA discharges with chapters on the epidemiology, ethical and legal aspects, as well as social science perspectives. For clinicians in the disciplines of hospital medicine, pediatrics, emergency medicine, nursing, and psychiatry, the book also provides a patient-centered analysis of the problem, case-based discussions, and a discussion of best practices. This comprehensive review of AMA discharges and health care quality will interest physicians and other health care professionals, social workers, hospital administrators, quality and risk managers, clinician-educators, and health services researchers."--Back cover.

Summary: This book provides an updated overview of agammaglobulinemia, a rare form of primary immunodeficiency which is considered the prototype of the congenital humoral defects, and which is characterized by the absence of peripheral B cells and very low serum immunoglobulin levels. The book opens by discussing the highly orchestrated early B cell development in the bone marrow and the genes involved based on both human and animal models. The pathogenesis and clinical presentation of X-linked agammaglobulinemia, caused by mutations in the BTK (Bruton's tyrosine kinase) gene, are then presented in detail, followed by descriptions of the clinical manifestations and molecular basis of the less frequent autosomal recessive and autosomal dominant forms of agammaglobulinemia. Patients' management in terms of respiratory complications, gammaglobulin replacement therapy and the potential value of novel experimental therapeutic strategies are discussed. The book's closing chapters offer a comprehensive and updated description of mutations in the BTK gene, and the expression and function of BTK in cells other than B cells.

Contents:
Early B Cell Biology
Agammaglobulinemia: Basic Pathogenesis and Clinical Spectrum (Including X-Linked and Autosomal Recessive Forms)
Pulmonary Complications in Agammaglobulinemia
Immunoglobulin Replacement Therapy: Past, Present, Future
Mutational Spectrum of BTK: A Comprehensive Description
Novel Therapeutic Options for X-Linked Agammaglobulinemia
BTK in Non B Cells.

Summary: "Artificial Intelligence (AI) is transforming human society in fundamental and profound ways. Not since the Age of Reason have we changed how we approach security, economics, order, and even knowledge itself. In the Age of AI, three deep and accomplished thinkers come together to consider what AI will mean for us all."

Contents:
Where we are
How we got here: technology and human thought
From Turing to today-and beyond
Global network platforms
Security and world order
AI and human identity
AI and the future
Afterword: a new reality.

Summary: This edited book focuses on the recent advances in our understanding of age-related macular degeneration (AMD), combining epidemiology and clinical diagnosis, with genetics and immunological aspects as well as the role of proteostasis and mitochondria before diving into new therapies including stem cell based approaches. AMD is a leading cause of largely incurable blindness worldwide and projected to double from 2.07 million to 5.44 million individuals by 2050 in the United States. Globally, 288 million individuals are projected to have AMD by 2040. The disease has enormous socioeconomic impact on the affected individuals, their families and the society. This book will bring together the state of the art basic science knowledge with clinically relevant findings and address the challenges for future research in AMD. The intersection of different disciplines will provide potential areas for further investigations to reduce the burden of blindness from AMD. This book offers an appealing and insightful resource for clinicians, scientists, students and fellows.

Contents:
1. Age-Related Macular Degeneration: Epidemiology and Clinical Aspects
2. Ocular Imaging for Enhancing the Understanding, Assessment, and Management of Age-Related Macular Degeneration
3. Histopathology of Age-Related Macular Degeneration and Implications for Pathogenesis and Therapy
4. Bruchs Membrane and the Choroid in Age-Related Macular Degeneration
5. Innate Immunity in Age-Related Macular Degeneration
6. Immunological Aspects of Age-Related Macular Degeneration
7. AMD Genetics: Methods and Analyses for Association, Progression, and Prediction
8. Making Biological Sense of Genetic Studies of Age-Related Macular Degeneration
Age-Related Macular Degeneration: From Epigenetics to Therapeutic Implications
10. Mitochondria: The Retinas Achilles Heel in AMD
11. Cell-Based Therapies for Age-Related Macular Degeneration
12. Current Management of Age-Related Macular Degeneration.

Summary: "Groundbreaking exploration of the sociology of dementia -- with contributions from distinguished international scholars and practitioners. Organised around the four themes of personhood, care, social representations and social differentiation, Ageing, Dementia and the Social Mind provides a critical look at how modern concepts and assumptions regarding dementia can benefit from sociology and other disciplines. This collection addresses the gaps in our sociological knowledge of dementia and provides a forum for the development of new themes and perspectives within the health social sciences. This important work breaks new ground in giving specific attention to the social and cultural dimensions of responses to dementia"-- Provided by publisher.

Contents:
Ageing, dementia and the social mind: past, present and future perspectives / Paul Higgs, Chris Gilleard
Relational citizenship: supporting embodied selfhood and relationality in dementia care / Pia Kontos, Karen-Lee Miller, Alexis P Kontos
Shifting dementia discourses from deficit to active citizenship / Linda Birt, Fiona Poland, Emese Csipke, Georgina Charlesworth
Narrative collisions, sociocultural pressures and dementia: the relational basis of personhood reconsidered / Edward Tolhurst, Bernhard Weicht, Paul Kingston
Power, empowerment, and person-centred care: using ethnography to examine the everyday practice of unregistered dementia care staff / Kezia Scales, Simon Bailey, Joanne Middleton, Justine Schneider
Institutionalising senile dementia in 19th-century Britain / Emily Stella Andrews
Dichotomising dementia: is there another way? / Patricia Mc Parland, Fiona Kelly, Anthea Innes
When walking becomes wandering: representing the fear of the fourth age / Katherine Brittain, Cathrine Degnen, Grant Gibson, Claire Dickinson, Louise Robinson
Re-imagining dementia in the fourth age: the ironic fictions of Alice Munro / Marlene Goldman
Social class, dementia and the fourth age / Ian Rees Jones
Precarity in late life: rethinking dementia as a 'frailed' old age / Amanda Grenier, Liz Lloyd, Chris Phillipson.

Summary: The present book intends to provide an update on immunosenescence and how deficiencies in the immune system contribute to a higher susceptibility to infections, decline in organ function, reduced vaccination responses, age-related disease and the ageing process itself, negatively affecting longevity. Our focus is on the main changes in immune system cells and their products occurring during the ageing process and the possible consequences for health and disease. This includes: discussion of the modulatory and/or suppressive mechanisms associated with the alterations in T regulatory cells, B regulatory cells and Myeloid Derived Suppressor cells; changes in the immune system observed in chronic neurodegenerative diseases, cancer, lung disease and frailty will also be discussed. Most importantly we provide recent literature information about possible interventions (focusing on physical activity) that could alleviate the negative effects of immunosenescence. The Ageing Immune System and Health is a comprehensive guide on the field intended to all physicians, researchers, professors and students interested on relationship between immune system, ageing and health. .

Contents:
1. Introduction
2. Innate Immune Response and Ageing (neutrophils, monocytes, dendritic cells, DAMPs, PAMPs
3. Adaptive Immune Response and Aging (T and B lymphocytes, naïve, effector and memory phenotypes and functions)
4. Modulatory/Suppressive Cells and Ageing (T regulatory cells, B regulatory cells, Myeloid Derived Suppressor Cells, Modulatory Neutrophils, M1 and M2 macrophages)
5. Mucosal Immune System and Ageing
6. Epigenetics and Ageing
7. Cancer and Ageing
8. Infections/Vaccination and Ageing
9. Cytomegalovirus and immmunosenescence
10. Frailty and Ageing
11. Inflammation and Neurodegenerative Diseases and Ageing
12. Effects of chronic inflammatory diseases (chronic kidney disease, rheumatoid arthritis, crohns disease etc) on the ageing of the immune system
13. Interventions in Elderly focusing Immunosenescence (physical activity, nutrition, supplements).

Summary: Spending the final chapter of your life in a nursing home is considered, by many, a fate worse than death. Others, however, have found that through enlightened, imaginative care even the frailest of lives can flourish. The key to such a transformation is to replace the constricting custodial centres of the past with a more informed, research-based approach. This book is timely, responding to evidence of the urgent need for change described in the Australian Royal Commission into Aged Care Quality and Safety Final Report: Care, Dignity and Respect and its predecessor subtitled Neglect. In this book, the author proposes a model of care that places the whole person at its centre, sidestepping the constraints of a reductionist funding model that focusses on residents' deficits and the proprietors financial gain. Aged care requires a comprehensive research-based guide to fulfil this aim. Narratives are included throughout the book to reinforce the fact that nursing home care is about individual residents and their unique lives. Topics explored in various chapters include: Ageing in a Changing Community Social, Gerontological Care A Palliative Approach Community Expectations Ageing in a Nursing Home: Foundations for Care takes a realistic approach that draws on contemporary research and narratives from the unique lives of older Australians who, despite their frailty, teach us how to care. Such knowledge informs and influences their future. The book is a resource intended for all who have a stake in the provision of best practice residential aged care, and all who benefit from such care. Its academic appeal will include those who design and teach courses in aged care: gerontology, general practice medicine, nursing, attendant care, allied health, and chaplaincy. Academics and teachers will find useful, well-referenced material for their courses, together with ample scope for researchers.

Contents:
Ageing in a changing community
Communication: the key to care
Social, gerontological care
Dementia challenges
A palliative approach
Death and dying
Leadership
Community expectations.

Summary: This book demonstrates that there are wide-ranging potential challenges in addressing issues associated with ageing populations in both developed and developing countries of the region. This book brings together local, national and regional perspectives on the ageing population and sustainable development nexus in selected countries in the Asia Pacific region. The countries selected in this book include a mix of developed and developing economies that all reflect strong trade, investment and migration linkages. While the Asia Pacific region is forecast to enjoy high growth in the coming decade, a recurring common policy challenge is addressing the demographic time bomb posed by ageing populations and workforces (Montague et al., 2017). Consequently, this book focuses on strategic policies and practices of multiple stakeholders, primarily: governments, industry and education systems, together with, the range of aged care services providers in more effectively addressing these key socio-economic challenges associated with the ageing population for sustainable development.

Contents:
Part I Context and Setting the Scene
Chapter 1 Population Ageing: Challenges in the Asia Pacific and Beyond
Chapter 2 Addressing the Challenges of Ageing: Global Perspectives on Policies and Practices
Chapter 3 A Bibliometric Analysis of Ageing Literature: Global and Asia-Pacific Trends
Part II Country Case Studies
Chapter 4 Ageing, work, care in Australia: Progress and prospects in meeting Sustainable Development Goals of inclusive growth and gender equality
Chapter 5 Bridging the gap in social infrastructure for the ageing population in Bangladesh
Chapter 6 Ageing population and sustainable development: Evidence from China
Chapter 7 Sustainable development Goals and Ageing: Status, Challenges, and Strategies for Policy Implications for India
Chapter 8 Financial Stability or Instability in their Golden Years: An Analysis of the Financial Preparedness of Malaysians
Chapter 9 Ageing Population, the Poverty Nexus and Wellbeing of Elderly in Mauritius
Chapter 10 Ageing and Health Agenda for Nepal: Challenges and Policy Responses for Sustainable Development
Chapter 11 Recalibrating Social Protection for an Ageing Singapore
Chapter 12 Population ageing and societal inequalities: the case of Taiwan
Chapter 13 Ageing, work-life and lifestyle: Reflections from Thailand
Part III Comparative Analysis and Conclusion
Chapter 14 Comparative Analysis of Countries Ageing Challenges & Policies.

Summary: Based on the latest research, Aggression: Clinical Features and Treatment Across the Diagnostic Spectrum is designed to aid mental health practitioners in identifying and treating aggression in diverse patient presentations.

Contents:
Nature and psychobiology of intermittent explosive disorder / Emil F. Coccaro, Royce Lee, and Michael S. McCloskey
Treatment of intermittent explosive disorder / Michael S. McCloskey, Martha K. Fahlgren, and Emil F. Coccaro
Aggression in autism and other developmental disorders / Laura C. Politte, Sarah E. Fitzpatrick, and Craig Erikson
Aggression in disruptive behavioral disorders beginning in childhood / Beth Krone, Iliyan Ivanov, and Jeffrey Newcorn
Aggression in primary psychotic disorders / Leslie Citrome, and Jan Volavka
Aggression in bipolar disorder / Susan L. McElroy, Brian E. Martens, and Paul E. Keck, Jr
Aggression in unipolar mood disorders / Maurizio Fava, and Ellen Leibenluft
Aggression in anxiety disorders / Emily B. O'Day, M.A. and Richard G. Heimberg
Aggression and its relationship to obsessive compulsive disorder / Jon E. Grant and Samuel R. Chamberlain
Aggression in posttraumatic stress disorder / Jennifer R. Fanning
Aggression in eating disorders / Karen M. Jennings, Lindsay P. Bodell, and Jennifer E. Wildes
Aggression and alcohol use disorders / Caroline W. Grant, and David T. George
Aggression and substance use disorders / Rachel R. Gunn, Kyle R. Gerst, and Daniel J. Fridberg
Aggression in personality disorders / Royce J. Lee
Legal and forensic aspects of aggression / Michael Greenage, and Robert L Trestman.

Summary: This book summarizes current knowledge of the biology and molecular pathogenesis of aggressive lymphomas and reviews the state of the art in diagnostic and therapeutic strategies. The aim is both to provide the reader with a sound understanding of the very significant progress that has been achieved in the understanding and management of these malignancies over recent years and to facilitate appropriate choice of the therapeutic strategy in individual cases. The assessment of different prognostic parameters are clearly presented in order to permits effective risk stratification that impacts on treatment choice. Recent insights into lymphomagenesis are exemplified and may assist in identifying emerging therapeutic targets. The comprehensive and up-to-date nature of the book will make it an ideal reference for all physicians and researchers interested in lymphoma, including clinicians from various medical specialties, biologists, pathologists, radiologists and nuclear medicine specialist, as well as students.

Contents:
Epidemiology, pathology and molecular pathogenesis
Standard of care of aggressive lymphomas
Future directions in aggressive lymphomas.

Contents:
The Commitment of human cells to senescence / R. Holliday
Evolutionary theories of aging can explain why we age / E. Le Bourg
Control of cell replication during aging / A. Macieira-Coelho
Cell senescence : role in aging and age-related diseases / J. Campisi, L. Robert,
Aging of cell membranes : facts and theories / I. Zs.-Nagy
Oxidative stress, mitochondrial dysfunction, and the mitochondria theory of aging / Y. Kong, S.E. Trabucco, H. Zhang
Aging of connective tissues : experimental facts and theoretical considerations / J. Labat-Robert, L. Robert
Aging of cell communication : loss of receptor function / L. Robert, T. Fulop
On the immunological theory of aging / T. Fulop, J.M. Witkowski, G. Pawelec, C. Alan, A. Larbi
Aging of the brain, dementias, role of infectious proteins : facts and theories / F. Morinet
Aging as alteration / P.-A. Miquel
Longevity and its regulation : centenarians and beyond / L. Robert, T. Fulop.

Contents:
v. 1. Biology / edited by D. Danon, N.W. Shock, and M. Marois
v. 2. Medicine / edited by A.J.J. Gilmore, A. Svanborg, M. Marois. Social sciences and social policy / edited by Walter M. Beattie, Jr., Jerzy Piotrowski, M. Marois
v. 3. Behavioural sciences / edited by James E. Birren ... [et al.]. Conclusions and perspectives / edited by Maurice Marois.

Summary: Aging, Health and Technology takes a problem-centered approach to examine how older adults use technology for health. It examines the many ways in which technology is being used by older adults, focusing on challenges, solutions and perspectives of the older user. Using aging-health technology as a lens, the book examines issues of technology adoption, basic human factors, cognitive aging, mental health, aging and usability, privacy, trust and automation. Each chapter takes a case study approach to summarize lessons learned from unique examples that can be applied to similar projects, while also providing general information about older adults and technology.

Contents:
1. Rethinking technology development for older adults: a responsible research and innovation duty
2. Challenges associated with online health information seeking among older adults
3. Improving older adults' comprehension and use of patient portal-based health information
4. Bringing older drivers up to speed with technology: cognitive changes, training, and advances in transportation technology
5. Technological supports to increase nature contact for older adults
6. Design and development of an automated fall risk assessment system for older adults
7. Checking-in with my friends: results from an in-situ deployment of peer-to-peer aging in place technologies
8. Enhancing social engagement of older adults through technnology
9. Virtual cognitive training in healthy aging and mild cognitive impairment
10. Social agents for aging-in-place: a focus on health education and communication
11. Design of human centered augmented reality for managing chronic health conditions
Index.

Summary: "This book provides an overview of recent advances in the study of aging and aging related diseases, discussing the topics at individual, organ, tissue, cell, and molecular levels. It also presents studies on the biomarkers of aging and anti-aging interventions. Aging has been becoming a global health problem. However it was not possible to determine aging as we usually diagnose a disease because there are few biomarkers for age estimation. Since ancient times, people have been seeking anti-aging substances and methods for achieving immortality, while the scientific study of aging has only existed for 100 years. This book appeals to researchers both in institutes and in pharmaceutical companies interested in further studies in this field"--Publisher's description.

Contents:
Systems biology in aging research / Xian Xia, Jing-Dong J. Han
Circular RNA in aging and age-related diseases / Deying Yang, Katie Yang, Mingyao Yang
Noncoding RNAs in cardiovascular aging / Yongqin Li, Yujiao Zhu, Guoping Li, Junjie Xiao
Epigenetic regulation of vascular aging and age-related vascular diseases / Yang-Nan Ding, Xiaoqiang Tang, Hou-Zao Chen, De-Pei Liu
Apoe and neurodegenerative diseases in aging / Yuemiao Yin, Zhao Wang
Brain aging: HSP90 and neurodegenerative diseases / Kun Wang, Yu Shang, Fei Dou
Aging of human adult stem cells / Han Xie, Shouliang Zhao, Shangfeng Liu
Mechanisms of hematopoietic stem cell ageing and targets for hematopoietic tumour prevention / Min Liao, Jianwei Wang
Microbiota and aging / Maoyang Lu, Zhao Wang
Intestinal homeostasis and longevity: Drosophila gut feeling / Xiaolan Fan, Uma Gaur, Mingyao Yang
Aging kidney and aging-related disease / Zhongchi Li, Zhao Wang
Aging of the bone / Yu Wei, Yao Sun
Ovarian aging and osteoporosis / Liyuan Li, Zhao Wang
Biomarkers of aging / Xiaojuan Bai
Pharmaceutical intervention of aging / Minxian Qian, Baohua Liu
Application of stem cell technology in antiaging and aging-related diseases / Yanqiu Yu
Which is the most reasonable anti-aging strategy: meta-analysis / Yaru Liang, Zhao Wang

Contents:
Introduction to the theory of aging networks / Witten, T.M.
Applications to aging networks / Wimble, C., Witten, T.M.
Computational systems biology for aging research / Auley, M.T., Mooney, K.M.
How does the body know how old it is? Introducing the epigenetic clock hypothesis / Mitteldorf, J.
The great evolutionary divide : two genomic systems biologies of aging / Rose, M.R., Cabral, I.G., Philips, M.A., Rutledge, G.A., Phung, K.H., Mueller, L.D., Greer, L.F.
Development and aging : two opposite but complementary phenomena / Feltes, B.C., De Faria Poloni, J., Bonatto, D.
Aging as a process of deficit accumulation : its utility and origin / Mitnitski, A., Rockwood, K.
Low-grade systemic inflammation connects aging, metabolic syndrome and cardiovascular disease / Guarner, V., Rubio-Ruiz, M.E.
Modulating mTOR in aging and health / Johnson, S.C., Sangesland, M., Kaeberlein, M., Rabinovitch, P.
Melatonin and circadian oscillators in aging : a dynamic approach to the multiply connected players / Hardeland, R.
Diet-microbiota-health interactions in older subjects : implications for healthy aging / Lynch, D.B., Jeffery, I.B., Cusack, S., O'Connor, E.M., O'Toole, P.W.
Systems biology approaches in aging research / Chauhan, A., Liebal, U.W., Vera, J., Baltrusch, S., Junghanss, C., Tiedge, M., Fuellen, G., Wolkenhauer, O., Köhling, R.
Conservative growth hormone/IGF-1 and mTOR signaling pathways as a target for aging and cancer prevention : do we really have an antiaging drug? / Anisimov, V.N.

Summary: This book synthesizes the major research advances in molecular, biochemical, and translational aspects of aging and heart failure over the last four decades and addresses future directions in management and drug discovery. It presents clinical issues and molecular mechanisms related to heart failure, including the changing demographics in the aging population with heart failure; hypertension and prevention of diastolic heart failure in the aging population; polypharmacy and adverse drug reactions in the aging population with heart failure; changes in the heart that accompany advancing age from humans to molecules; aging-associated alterations in myocardial inflammation and fibrosis; and aging-related changes in mitochondrial function and implications for heart failure therapy. The book succinctly summarizes the large volume of data on these key topics and highlights novel pathways that need to be explored. Featuring contributions from leading clinician-scientists, Aging and Heart Failure: Mechanisms and Management is an authoritative resource on the major clinical issues in heart failure therapy in the elderly for cardiologists, gerontologists, and internists.

Contents:
Changing demographics of the aging population with heart failure and implications for therapy
Biology of aging and implications for heart failure therapy and prevention
Hypertension and prevention of diastolic heart failure in the aging population
Aging and optimal therapy of systolic heart failure in the elderly
Atrial fibrillation and heart failure in the aging population
Optimizing therapy of heart failure in the aging population with monitoring in clinics
Cardiac alterations in aging, hypertension and diastolic heart failure
Polypharmacy and adverse drug reactions in the aging population with heart failure
Aging-related changes in vascular biology and implications for heart failure therapy in the aging population
Biomarkers and optimal management of heart failure in the aging population
Benefits of Exercise in the elderly
The RAAS in heart failure: an update on clinical trials and opportunities for therapy
Aging and diastolic dysfunction {u2013} the interplay of inflammation and extracellular matrix regulation
Reperfusion and vasodilator therapy in elderly patients with STEMI and heart failure. Improving outcomes
Erythropoietin therapy for heart failure
Role of resistin in heart failure in the elderly
Role of coronary artery calcium in cardiovascular risk stratification and management in the aging population
Aging-and remodeling of the RAS and RAAS and related pathways. Implications for heart failure therapy
Aging and right ventricular failure from pulmonary hypertension: Effect of right ventricular and pulmonary artery remodeling
Biomarkers of cardiovascular aging
Changes in the heart that accompany advancing age: Humans to molecules
Aging-related changes in cell death and cell survival pathways and implications for heart failure therapy
Aging-related changes in telomeres and telomerases and implications for heart failure therapy
Aging associated alterations in myocardial inflammation and fibrosis: pathophysiological perspectives and clinical implications
Aging-related changes in extracellular matrix: implications for ventricular remodeling following myocardial infarction
Calcium handling defects and changes in cardiac function in the aging heart
Integrins: Implications for aging in heart failure therapy
Adipokines as novel biomarkers in aging and heart failure
Aging-related changes in cellular and molecular mechanisms of post-infarction remodeling. Implications for heart failure therapy
Aging-related changes in mitochondrial function and implication for heart failure therapy
Regulation of SERCA via oxidative modifications: Implications for the pathophysiology of diastolic dysfunction in the aging heart
SMP-30 and aging-related cardiac remodeling and heart failure.

Contents:
Introduction. Mental Health and Aging
Basic Gerontology for Working with Older Adults
Psychological Bases of Positive Mental Health
Models of Mental Health in Later Life. Models of Mental Health in Later Life
Psychodynamic Model / Lacey Edwards
Cognitive-Behavioral Model
Stress and Coping Model
Family Systems Model
Summary and Commentary
Introduction to Mental Disorders. Introduction to Mental Disorders
Cognitive Impairment and Neurocognitive Disorders
Major Depression and Bipolar Disorder
Serious Mental Disorders in Older Adults / Stephen J Bartels, Karen L Fortuna, John A Naslund
Anxiety Disorders, Hoarding Disorder, and Post-Traumatic Stress Disorder
Sexual Disorders, Sleep Disorders, and Chronic Pain
Substance-Related Disorders and Personality Disorders
Settings and Contexts of Mental Health. Settings and Contexts of Mental Health
Health Services Delivery Systems
Housing, Social Services, and Mental Health
Family and Friend Relationships, and Caregiving
Ethical Issues in Work with Older Adults.

Summary: Increasingly, we hear of more and more elders falling victim to financial exploitation. Although this form of elder abuse has been recognized for years, its incidence, prevalence, and impact on the common individual has been only more recently brought to the spotlight. Despite these circumstances, recognition of risk factors and indicators of financial exploitation are not widely disseminated. Additionally, once situations are identified and confronted, the knowledge of what to do next is lacking. These gaps are present within the medical community, law-enforcement, and the finance community ? areas where opportunities for recognition and intervention are common. Our elders often have no idea of what to do when they see their own risk or when they fall victim. Aging and Money: Reducing Risk of Financial Exploitation and Protecting Financial Resources helps clinicians to integrate identification of such indicators of abuse into their geriatric assessment as well as guide them in performing an assessment of an individuals? financial decision-making capacity when appropriate. Aging and Money: Reducing Risk of Financial Exploitation and Protecting Financial Resources is an essential new text that provides the practicing clinician with information on identifying risk factors and clinical clues associated with financial exploitation and how to incorporate these steps into their practice.

Contents:
Financial exploitation of the elderly: Review of the epidemic? its victims, national impact and legislative solutions
One Piece of the Puzzle ? Financial Exploitation and Elder Abuse
Barriers to Recognition
Financial Abuse of the Elderly
Risk Factors
Screening Older Patients for Risk Factors Associated with Financial Exploitation
Clinical Assessment of Financial Decision Making Capacity
Next Steps: Documentation and Accessing Community Healthcare Resources
Financial Exploitation ? The Legal Perspective
Financial and Legal Methods to Protect Individuals from Financial Exploitation
Critical Documents Associated with Aging: An Organized Guide to Personal Files
Who Can You Turn To ? the Role of Adult Protective Services (APS) and Other Community Resources
Being the Advocate ? Disseminating Knowledge About Financial Exploitation to the Community
Future Directions: Public Policy and Advocacy.

Summary: This book aims to disseminate and share knowledge about financial exploitation of elders with the purpose of protecting those individuals in our society who are most vulnerable to financial abuse and mistreatment. It instructs practicing clinicians in identification of risk factors, recognition of signs, and implementation of screening methods to protect their patients. This updated edition expands upon and advances the earlier text by including the most recent research and methods used to assess risk of financial exploitation, as well as updates in how the law approaches such cases. It also highlights ways in which community awareness can aid in identifying those most at risk, effectively protecting the elderly community, advocating for those victimized, and pursuing perpetrators to the fullest extent of the law. Professionals from law enforcement, medical clinics, financial institutions, and the legal field are now tasked with acting on suspected situations thanks to increasing recognition of financial abuse and mistreatment of an aging population. This book also guides professionals on how to discuss this information with potential victims. This second edition of Aging and Money expands the knowledge base to highlight the perspectives of different disciplines including professionals in medicine, law, the financial industry, and social services who play an important role in investigating and preventing financial abuse of the elderly.

Contents:
Financial Exploitation: Facts and figures
One Piece of the puzzle-Financial Exploitation and Elder Abuse
Why We Don't See or Do More
Barriers to Recognition and Action
Risk Factors: the Individual and the Caregiver
Screening for Financial Exploitation in Clinical Settings
Clinical Assessment of Financial Decision-Making Capacity
Next Steps: Documentation and Accessing Community Resources
Financial Exploitation-the Legal Perspective
Legal Barriers in Investigating Financial Exploitation
Being the Advocate-Disseminating Knowledge about Financial Exploitation to the Community
Documents Associated with Aging
Financial and Legal Methods to Protect Your Assets
Who Can You Run To
the Role of Adult Protective Services and Other Community Resources
Future Directions: Public Policy and Advocacy.

Summary: This is the second edition of a well received book that reviews classical epidemiological and clinical research designs, with a specific focus on aging. Chapters cover basic topics like the scientific method, ethics, and the consequences of certain exclusion criteria. The work also includes a look at clinical concepts like multimorbidity, frailty and functionality. New material includes chapters such as geroscience, health systems research, big data and data mining, financing and future of aging research. The authors reveal the issues and challenges for researchers of age and aging, and also consider, from basic to clinical, and from clinical to public policies of social and health care. The focus on aging is what gives this book its valuable perspective on research methodology. All authors have considerable experience in aging, geriatrics or gerontology, and each chapter includes both a theoretical framework and practical examples of studies in aging. Readers will discover study designs that are reviewed for basic structure, main flaws and advantages, and are analyzed for specific conditions and variables regarding aging. This text is suited to both health care professionals caring for older adults, and researchers who are new to research in aging. It is relevant across the disciplines, including medicine, psychology, social sciences and dentistry, and it supports learning with graphs and figures.

Summary: "This book discusses the aging voice, one of the interesting issues related to aging. Population aging is an issue in most developed countries, where both physicians and specialists are required to improve clinical and scientific practice for elderly adults. In particular, the need for expertise in the diagnosis and treatment of aging voice pathologies is increasing continually. New developments in regenerative medicine have taken care for the aging voice to new level, and the contributors to this book use their wealth of experience in the field of the aging voice to present the latest advances in this field. This book is a unique resource, providing new perspectives for physicians, clinicians and health care workers who are interested in the aging voice."--Back cover.

Contents:
Overview / Shigeru Hirano
Age-Related Histological Changes of the Vocal Folds / Masanobu Mizuta
Age-Related Changes in the Human Voice / Hideki Kasuya and Hajime Yoshida
Evaluation of Phonatory Function in the Elderly / Hiroumi Matsuzaki and Kiyoshi Makiyama
Clinical Assessment of Elderly Vocal Folds by Laryngoscopy / Yoichiro Sugiyama
Quantitative Analysis of High-Speed Digital Imaging for the Elderly / Akihito Yamauchi and Niro Tayama
Collagen Injection for the Elderly with Dysphonia / Hiroumi Matsuzaki and Kiyoshi Makiyama
Fat Injection for Voice Improvement in Atrophic Vocal Folds / Etsuyo Tamura
Voice Therapy for the Elderly / Mami Kaneko
Current Topics in Regenerative Medicine for the Laryngeal Tissues / Yo Kishimoto
Future Prospects / Shigeru Hirano and Shin-ichi Kanemaru.

Summary: This open access book outlines the challenges of supporting the health and wellbeing of older adults around the world and offers examples of solutions designed by stakeholders, healthcare providers, and public, private and nonprofit organizations in the United States. The solutions presented address challenges including: providing person-centered long-term care, making palliative care accessible in all healthcare settings and the home, enabling aging-in-place, financing long-term care, improving care coordination and access to care, delivering hospital-level and emergency care in the home and retirement community settings, merging health and social care, supporting people living with dementia and their caregivers, creating communities and employment opportunities that are accessible and welcoming to those of all ages and abilities, and combating the stigma of aging. The innovative programs of support and care in Aging Well serve as models of excellence that, when put into action, move health spending toward a sustainable path and greatly contribute to the well-being of older adults.

Contents:
Demographics
Healthcare in the United States
Long-term care financing
Person-centered long-term care
Home-based palliative care and aging in place and community
Coordinated primary care
Emergency medicine and hospital care in the home and community
Support for those living with dementia and their caregivers
Merging health and social services
Purpose and inclusion
Eight lessons for social inclusion and high-quality sustainable care.

Summary: Agricultural biocatalysis is of immense scientific interest nowadays owing to its increasing importance in the efforts for more sustainable agriculture while optimizing environmental impacts. Plant compatibility is essential for developing eco-friendly andsustainable microbial products.Therefore, our search for novel technologies ought to be in the foreground, for which athorough understanding of biochemical processes, application of agricultural enzymes, traits, and viruses get the highest priority. Volumes 8 to 10 in this series compile the recent research on agricultural biocatalysis by interdisciplinary teams from international institutes for chemistry, biochemistry, biotechnology, and materials and chemical engineering, who have been investigating agricultural-biocatalytic topics related to biochemical conversions or bioremediation, and modern biological and chemical applications exemplified by the use of selected and highly innovative agricultural enzymes, traits, and viruses. The editors are prominent researchers in agrochemistry and theoretical biophysical chemistry, and these three volumes are useful references for the students and researchers in the fields of agrochemistry, biochemistry, biology, biophysical chemistry, natural product chemistry, materials, and drug design. Volume 9 covers the research on plant and soil enzymes, herbicide tolerant traits, biochemical conversions, including aspects from bioremediation, plant viruses, and evaluation of the agricultural enzymes market.

Summary: Nanobiotechnology in agriculture is a new knowledge area that offers novel possibilities to achieve high productivity levels at manageable costs during the production and merchandising of crops. This book shows us how we can use the cutting-edge knowledge about agriculture, nanotechnology, and biotechnology to increase the agricultural productivity and shape a sustainable future in order to increase the social welfare in rural areas and preserve the environmental health. Specialists from several countries will provide their feedback on a range of relevant topics such as environment-friendly use of nanofertilisers, nanodevices, nano-food packaging, nanocoating and nanocarriers and their relationship with the modern agriculture.

Contents:
Part I. Agronanobiotechnology, an introduction to nanoparticles: Use of agronanobiotechnology in the agro-food industry to preserve environmental health and improve the welfare of farmers
Design and production of nanofertilizers
Part II. Fertiliszers and plant nutrients on germination, growth and development of crops: Nanofertilizers and their controlled delivery of nutrients
Incorporation of nanoparticles into plant nutrients : the real benefits
Effects of nanoparticles on germination, growth, and plant crop development
Effect of nanoparticles on the growth and development of crops for indoor agriculture applications
Part III. Improving the soil and water quality: Nanomaterials : new agrotechnology tools to improve soil quality?
Agronanobiotechnologies to improve the water quality in irrigation systems
Part IV. Environmental topics: Effects of nanoparticles on plants, earthworms, and microorganisms
Engineered nanoparticles : are they an inestimable achievement or a health and environmental concern?

Summary: A food system comprises the entire range of actors and interlinked activities related to food production, processing, distribution, marketing and trade, preparation, consumption, and disposal. When a food system operates without compromising the needs of future generations, it is considered to be a "Sustainable Food System." The present-day food systems in Sri Lanka are diverse, and the natural and physical environment, infrastructure, institutions, society and culture, and policies and regulations within which the food systems operate, as well as the technologies employed, have shaped their outcomes. Agricultural research is a key factor in terms of innovation and technological advances. Innovation has been the main driver of food systems' transformation over the past few decades and will be critical to addressing the needs of a rapidly growing population in a context of climate change and scarcity of natural resources. In addition, agricultural research must help meet the rising demand for food at affordable prices. Comprising 17 chapters written by specialist(s) in their respective subject-areas, this Contributed Volume on "Agricultural Research for Sustainable Food Systems in Sri Lanka: A Historical Perspective" shares the scientific knowledge accumulated by the National Agricultural Research System of Sri Lanka, including universities, and offers recommendations on how to make food systems more sustainable in order to address the current needs of Sri Lankan society. It presents perspectives on four key thematic areas, namely: (i) Crop and animal production, management, and improvement, (ii) Agro-product processing technologies, (iii) Natural resource management, and (iv) Socio-economic development and agri-business management.

Contents:
Intro
Acknowledgements
Contents
Editors and Contributors
About the Editors
Contributors
Abbreviations
1: Food Systems in Sri Lanka: Components, Evolution, Challenges and Opportunities
1.1 Food System: The Concept
1.1.1 What Is a Food System?
1.1.2 Why Sustainable Food Systems?
1.1.3 Why Food System Approach Is Needed to Achieve Development Targets?
1.2 Measuring Performance and Drivers of Food Systems
1.3 Evolution of Food Systems of Sri Lanka
1.3.1 The Key Components of the Food System 1.3.2 Agricultural Production System in the Economy of Sri Lanka
1.4 Performance of Food Systems in Sri Lanka
1.4.1 Agricultural Production System
1.4.2 Agricultural Marketing System
1.4.3 Food and Nutrition Security
1.4.4 Policies, Institutions and Regulations
1.5 The Way Forward for Sri Lanka: Opportunities and Challenges
References
2: Nutrition Transition in Sri Lanka: A Meta-Analysis of the Nutrition Profile
2.1 Introduction
2.2 Contextual Background
2.2.1 Key Characteristics of the Sri Lankan Economy 2.2.2 Food and Nutrition Policy Framework During 1977-2017
2.2.2.1 Food Assistance and Safety Net Programs
2.2.2.2 Nutritional Interventions
2.2.3 Diet Transformation
2.2.3.1 Dietary Nutrient Intake
2.2.3.2 Vegetable and Fruit Consumption
2.2.3.3 Meat and Fish Consumption
2.2.3.4 Sugar and Salt Intake
2.3 Methodology
2.3.1 Approach
2.3.2 Meta-Database and Eligibility Criteria
2.3.3 Tabular Analysis
2.3.4 Regression Analysis
2.4 Results
2.4.1 Trends in Nutritional Status and Determinants 2.4.1.1 Status of Undernutrition among Preschool Children
2.4.1.2 Status of Undernutrition Among Adolescents and Adults
2.4.1.3 Determinants of Undernutrition
2.4.2 Micronutrient Deficiencies
2.4.3 Overweight and Obesity
2.4.3.1 Overweight and Obesity Among Preschool Children
2.4.3.2 Overweight and Obesity Among Adult Men and Women
2.4.3.3 Determinants of Overweight and Obesity
2.5 Diagnosis of Nutrition Transition
2.5.1 Key Trends, Patterns in Malnutrition and Its Determinants
2.5.2 Results of the Econometric Analysis 2.6 Summary, Conclusions, and Way Forward
2.6.1 Summary and Conclusions
2.6.2 Way Forward
References
3: Cascaded Tank-Village System: Present Status and Prospects
3.1 Introduction
3.2 Cascaded Tanks
3.3 Early Studies of Tank Cascades
3.4 Cascade Ecology
3.5 Issues in Tank Cascade Systems
3.6 Restoration of Tank Ecosystem for Sustainable Use
References
4: Soil Survey, Classification and Mapping in Sri Lanka: Past, Present and Future
4.1 Introduction
4.2 Diversity of Soils of Sri Lanka

Summary: Microbes are ubiquitous in nature. Among microbes, fungal communities play an important role in agriculture, the environment, and medicine. Vast fungal diversity has been associated with plant systems, namely epiphytic fungi, endophytic fungi, and rhizospheric fungi. These fungi associated with plant systems play an important role in plant growth, crop yield, and soil health. Rhizospheric fungi, present in rhizospheric zones, get their nutrients from root exudates released by plant root systems, which help with their growth, development, and microbe activity. Endophytic fungi typically enter plant hosts through naturally occurring wounds that are the result of plant growth, through root hairs, or at epidermal conjunctions. Phyllospheric fungi may survive or proliferate on leaves depending on material influences in leaf diffuseness or exudates. The diverse nature of these fungal communities is a key component of soil-plant systems, where they are engaged in a network of interactions endophytically, phyllospherically, as well as in the rhizosphere, and thus have emerged as a promising tool for sustainable agriculture. These fungal communities promote plant growth directly and indirectly by using plant growth promoting (PGP) attributes. These PGP fungi can be used as biofertilizers and biocontrol agents in place of chemical fertilizers and pesticides for a more eco-friendly method of promoting sustainable agriculture and environments. This first volume of a two-volume set covers the biodiversity of plant-associated fungal communities and their role in plant growth promotion, the mitigation of abiotic stress, and soil fertility for sustainable agriculture. This book should be useful to those working in the biological sciences, especially for microbiologists, microbial biotechnologists, biochemists, and researchers and scientists of fungal biotechnology.

Contents:
Agriculturally Important Fungi: Plant
Microbe Association for Mutual Benefits
Endophytic Fungi: Diversity, Abundance, and Plant Growth Promoting Attributes
The Role of Arbuscular Mycorrhizal Fungal Community in Paddy Soil
Natural Arbuscular Mycorrhizal Colonization of Wheat and Maize Crops under different Agricultural Practices
Arbuscular Mycorrhizal Fungi, and their Potential Applications for Sustainable Agriculture
Phosphate Solubilizing Fungi: Current Perspective, Mechanisms and Potential Agricultural Applications
Fungal Phytohormones: Plant Growth-Regulating Substances and their Applications in Crop Productivity
Phytohormones Producing Fungal Communities: Metabolic Engineering for Abiotic Stress Tolerance in Crops
Fungal Biofertilizers for Sustainable Agricultural Productivity
Role of Algae-Fungi relationship in Sustainable Agriculture
Fungi as a Biological Tool for Sustainable Agriculture
Agriculturally Important Fungi for Crop Productivity: Current Research and Future Challenges.

Summary: This book examines the mechanisms and strategies farmers in North Australia adopt to manage the setbacks and challenges they face. This social research is based on farmers experiences, but also draws on the authors own experience after his tropical fruit farm was destroyed by two Category 5 cyclones in five years. Through historical analysis, the book compares historic and contemporary aspirations for northern development, and discusses the influence of the built environment on individuals as well as access to health and other social services. Exploring the implications of individual resilience strategies for policy development within the broader context of northern development and evolving environmental governance, the book also highlights the fact that this is occurring in a new geological epoch - the Anthropocene. The book will provide a unique perspective and understanding to government, individuals and industries interested in northern Australia and its relationship to the world.

Contents:
Intro; Introduction; Contents; About the Authors; List of Figures; List of Tables; Part I: North Australian Theory and Realities; Chapter 1: Agriculture as a Human Endeavour; 1.1 Northern Australia's Existing Agricultural Capacity; 1.2 Why Consider an Individual's Resilience?; 1.3 Book Structure and Chapter Logic; References; Chapter 2: Resilience Discourse and Adaption Strategies; 2.1 Introduction; 2.2 A Resilient Concept; 2.3 Conceptualising Resilience: Origins and Evolution; 2.4 What's in a Name: Theory vs the Vernacular; 2.5 Resilience, Adaptive Capacity and Transformation in Agriculture 2.6 Resilience and Policy Paradoxes2.7 Future Trends and Direction; 2.8 Conclusion; References; Chapter 3: Agricultural Development in Northern Australia; 3.1 Introduction; 3.2 The Historic Challenges of Northern Australian Agriculture; 3.3 Contemporary Challenges to North Australian Agricultural Aspirations; 3.4 National Drivers for Growth; 3.5 Global Drivers for Growth; 3.6 Agricultural Policy Paradigms; 3.7 The Importance of Infrastructure; 3.7.1 Freight and Transport Infrastructure; 3.7.1.1 Sea Freight; 3.7.1.2 Rail; 3.7.1.3 Road; 3.7.1.4 Air; 3.7.2 Communication Infrastructure 3.7.3 Water Infrastructure3.7.4 Infrastructure Summary; 3.8 Are We There Yet?; References; Chapter 4: Framing Northern Australian Agriculture's Future; 4.1 Introduction; 4.2 Australian Environmentalism and the Emergence of Sustainability; 4.3 Ecologically Sustainable Development; 4.4 Capital Ideas; 4.5 Traditional Owners and Agriculture; 4.6 Climate Change and Other Disasters; 4.7 Australian Agricultural Policy in the Anthropocene; 4.8 Global Decision-Making and Evolving Governance; 4.9 What Is Different Now?; References; Chapter 5: Why and How to Consider the Resilience of Individuals? 5.1 Introduction5.2 A Problem-Focus, as Distinct from a Topic-Focus; 5.3 A Review of Theory and Validation of the Methodological Approach; 5.4 The Ontology and Epistemology of This Work; 5.5 Methods and Strategy of Data Collection; 5.6 The Use of Orienteering Concepts to Organise and Analyse Data; 5.7 Approaching the Data; References; Part II: Lived Experience
Why People, Place, and Services Matter; Introduction; Chapter 6: The Resilience Strategies of Individuals; 6.1 Theme 1: Situational Awareness and Opportunity Seeking
The Black Art of Experience; 6.1.1 A Good Way of Life 6.1.2 Travel Broadens the Mind6.1.3 Off-Farm Influences; 6.1.3.1 Finance; 6.1.3.2 Infrastructure; 6.1.3.3 Global Drivers; 6.1.3.4 Natural Resource Management and Public Perceptions of Agriculture; 6.1.4 Acts of God, Acts of Parliament, and Other Disasters; 6.1.5 Dealing with It; 6.1.6 Discussion; 6.2 Theme 2: The Capacity to Plan; 6.2.1 Plan the Future, Not the Past; 6.2.2 The Path of Least Resistance; 6.2.3 More Than Just Me; 6.2.4 Stick to the Plan, Man; 6.2.5 Discussion and Conclusion; 6.3 Theme 3: The Capacity to Adapt; 6.3.1 Pay Attention; 6.3.2 Maintain Flexibility

Summary: Agroecological footprints are a unique and popular concept for sustainable food system. Measuring and keeping a tab on the agroecological footprints of various human activities has gained remarkable interest in the past decade. From a range of human activities, food production and agriculture are most essential as well as extremely dependent on the agroecosystems. It is therefore crucial to understand the interaction of agroecosystem constituents with the extensive agricultural practices. The environmental impact measured in terms of agroecological footprints for a healthy for the sustainable food system. The editors critically examine the status of agroecological footprints and how it can be maintained within sustainable limits. Drawing upon research and examples from around the world, the book is offering an up-to-date account, and insight into how agroecology can be implemented as a solution in the form of eco-friendly practices that would boost up the production, curbs the environmental impacts, improves the bio-capacity, and reduces the agroecological footprints. It further discusses the changing status of the agroecological footprints and the growth of other footprint tools and types, such as land, water, carbon, nitrogen, etc. This book will be of interest to teachers, researchers, government planners, climate change scientists, capacity builders, and policymakers. Also, the book serves as additional reading material for undergraduate and graduate students of agriculture, agroforestry, agroecology, soil science, and environmental sciences. National and international agricultural scientists, policymakers will also find this to be useful to achieve the 'Sustainable Development Goals'.

Contents:
Intro
Preface
Contents
About the Editors
1: Ecological Footprints in Agroecosystem: An Overview
1.1 Introduction
1.2 Concept of Ecological Footprint
1.3 Ecological Footprint and Sustainability
1.4 Ecological Footprint Analysis
1.5 Forms of Footprints
1.5.1 Water Footprint
1.5.2 Energy Footprint
1.5.3 Climate Footprint
1.5.4 Land Footprint
1.5.5 Nutrient Footprint
1.6 Carbon and Water Footprint in Agroecosystems
1.7 Research and Development in Ecological Footprint
1.8 Future Roadmap of Ecological Footprint in Agroecosystems 1.9 Policy and Legal Framework for Managing Footprint in Agroecosystem
1.10 Conclusion
References
2: Natural Resources Intensification and Footprints Management for Sustainable Food System
2.1 Introduction
2.2 Major Components of Agroecology in South Asia
2.2.1 Diversity
2.2.1.1 Diversity in Land Resources
2.2.1.2 Diversity in Water Resources
2.2.1.3 Diversity in Climate Change
2.2.1.4 Crops Diversification
2.2.1.5 Land Diversification
2.2.2 Establishment and Disseminate of Experiences
2.2.3 Government Policies, Institutions, and Public Goods 2.2.4 Synergies
2.2.5 Resource Use Efficiency
2.2.6 Recycling
2.2.7 Resilience Building
2.2.8 Social and Human Values
2.2.9 Tradition of Culture and Food
2.3 Impacts of Intensive Agriculture and Climate Change on Agroecology
2.3.1 Global Warming and Weather Migration
2.3.2 Land Value Degradation
2.3.3 Deterioration of Soil Quality
2.3.4 Worldwide Water Scarcity
2.3.5 Impact on Crop Production and Associative Environment
2.3.6 Occurrence of Extreme Events on Human
2.4 Natural Resources and Footprints in South Asia (SA)
2.4.1 Natural Resources of South Asia 2.4.2 Different Footprints
2.4.2.1 Carbon Footprint
2.4.2.2 Water Footprints
2.4.2.3 Energy Footprint
2.4.2.4 Emission Footprint
2.4.2.5 Nitrogen Footprint
2.4.2.6 Land Footprint
2.4.2.7 Biodiversity Footprint
2.4.2.8 Economic Footprint
2.4.2.9 Composite Footprint
Ecological Footprint
Sustainable Process Index
2.5 Management of Footprints for Sustainability
2.5.1 Management of Carbon Footprints
2.5.2 Crop Residues as Mulch
2.5.3 Tillage Modifications
2.5.4 Need to Change Dietary Habits
2.5.5 Reduces Wastage of Food 2.5.6 Reducing Methane Emissions from Rice Cultivation
2.5.7 Management of Water Footprints
2.6 Natural Resources Intensification for Agroecology Sustainability
2.7 Agroecology for Food Security
2.8 Adaptive Measures for Soil Ecology
2.9 Adaptive Measures for Crop Ecology Under Changing Climate
2.9.1 Adjustment in Sowing Time and Method
2.9.2 Stress Tolerant Cultivars
2.9.3 Cropping System
2.9.4 Conservation Tillage
2.9.5 Nutrient Management
2.9.6 Water Management
2.10 Conclusion
References

Summary: There is wide agreement on the need to change the prevalent agricultural models, given their negative impacts and their incompatibility with current societal issues. Agroecological transition has been promoted as a potential solution to the ecological, social and economic problems generated by these models. It however involves a systemic, multi-scale and transdisciplinary process. Due to this complexity, the overall picture of what farms and food systems "actually are" and "might be" may not be apparent at the individual level. Yet individuals' knowledge and values provide complementary insights on how to proceed in deepening ecological modernisation. Expertise can also provide landmarks to be considered in that process. Because local stakeholders' experience and skills are key resources in the adaptation and adoption of agroecological transition, new conceptual and methodological frameworks and tools have to be developed to support them in the design process of such a complex transition. This book presents feedback from the 'Territorial Agroecological Transition in Action'- TATA-BOX research project, which was devoted to these specific issues. The multidisciplinary and multi-organisation research team steered a four-year action-research process in two territories of France. This book presents: i) the key dimensions to be considered when dealing with agroecological transition: diversity of agriculture models, management of uncertainties, polycentric governance, autonomies, and role of actors' networks; ii) an operational and original participatory process and associated boundary tools to support local stakeholders in shifting from a shared diagnosis to a shared action plan for transition, and in so doing developing mutual understanding and involvement; iii) an analysis of the main effects of the methodology on research organisation and on stakeholders' development and application; iv) critical analysis and foresights on the main outcomes of TATA-BOX, provided by external researchers."

Contents:
Foreword; Dedieu Benoît
Chapter 1: General introduction; Jacques-Eric Bergez and Olivier Therond
Chapter 2: TATA-BOX at a glance; Jacques-Eric Bergez and Olivier Therond Part I: Territorial Agroecological Transition at a concept crossroads
Chapter 3: Socio-economic characterisation of agriculture models; Gaël Plumecocq, Thomas Debril, Michel Duru, Marie-Benoît Magrini, Jean-Pierre Sarthou and Olivier Therond
Chapter 4: An integrated approach to livestock farming systems' autonomy in designing and managing agroecological transition at the farm and territorial levels; Marie-Angélina Magne, Guillaume Martin, Marc Moraine, Julie Ryschawy, Vincent Thenard, Pierre Triboulet and Jean-Philippe Choisis
Chapter 5: Agroecological transition from farms to territorialised agri-food systems: issues and drivers; Marie-Benoît Magrini, Guillaume Martin, Marie-Angélina Magne, Michel Duru, Nathalie Couix, Laurent Hazard and Gaël Plumecocq
Chapter 6: A plurality of viewpoints regarding the uncertainties of the agroecological transition; Danièle Magda, Nathalie Girard, Valérie Angeon, Célia Cholez, Nathalie Raulet-Croset, Régis Sabbadin, Nicolas Salliou, Cécile Barnaud, Claude Monteil and Nathalie Peyrard
Chapter 7: Towards an integrated framework for the governance of a territorialised agroecological transition; Pierre Triboulet, Jean-Pierre Del Corso, Michel Duru, Danielle Galliano, Amélie Gonçalves, Catherine Milou and Gaël Plumecocq
Chapter 8: The key role of actors in the agroecological transition of farmers: a case-study in the Tarn-Aveyron Basin; Julie Ryschawy, Jean-Pierre Sarthou, Ariane Chabert and Olivier Therond Part II: Support methodology for territorial agroecological transition design, and feedback from the TATA-BOX project experience
Chapter 9: Participatory methodology for designing an agroecological transition at local level; Elise Audouin, Jacques-Eric Bergez and Olivier Therond
Chapter 10: Towards a reflective approach to research project management; Lorène Prost, Marie Chizallet, Marie Taverne and Flore Barcellini
Chapter 11: Evaluation of the operationalisation of the TATA-BOX process; Marie Taverne, Sarah Clément, Lorène Prost and Flore Barcellini Part III: New prospects and cross-cutting perspectives
Chapter 12: Information and communication technology (ICT) and the agroecological transition; Lola Leveau, Aurélien Bénel, Jean-Pierre Cahier, François Pinet, Pascal Salembier, Vincent Soulignac and Jacques -Eric Bergez
Chapter 13: TATA-BOX: A model for participatory processes?; Sylvie Lardon
Chapter 14: Review and Critique of the TATA-BOX Model; Charles A. Francis and Geir Lieblein
Chapter 15: Opening the TATA-BOX to raise new questions on agroecological transition; Jean-Marc Touzard, Jean-Marc Barbier, Laure Hossard.

Summary: Agronomic crops have been used to provide foods, beverages, fodders, fuels, medicines and industrial raw materials since the dawn of human civilization. Today, agronomic crops are being cultivated by employing scientific methods instead of traditional methods. However, in the current era of climate change, agronomic crops are subjected to various environmental stresses, which results in substantial yield loss. To meet the food demands of the ever-increasing global population, new technologies and management practices are being adopted to boost yield and maintain productivity under both normal and adverse conditions. Scientists are now exploring a variety of approaches to the sustainable production of agronomic crops, including varietal development, soil management, nutrient and water management, pest management, etc. Researchers have also made remarkable progress in developing stress tolerance in crops through different approaches. However, achieving optimal production to meet the increasing food demand is an open challenge. Although there have been numerous publications on the above-mentioned problems, and despite the extensive research being conducted on them, there is hardly any comprehensive book available. In response, this book offers a timely resource, addressing all aspects of production technologies, management practices and stress tolerance in agronomic crops in a single volume.

Contents:
Agronomic Crops: Types and Uses
Climate Resilient Minor Crops for Food Security
Climatic Variability and Agronomic Cropping Pattern
Soil Health in Cropping Systems: An Overview
Agronomic Cropping Systems in relation to Climatic Variability.-Growth and Development Dynamics in Agronomic Crops under Environmental Stress
Tillage and Crop Production
Effect of Planting Dates on Agronomic Crop Production
Crop production under changing climate
Past, Present and Future
Cultivation of Aromatic Rice: A review
Direct Seeding in Rice: Problems and Prospects
Advanced Production Technologies of Wheat
Advanced Production Technologies of Maize
Agrotechnologies of Baby Corn Production
Advanced Production Technologies of Millets
Advanced Production Technologies of Legumes Crops
Advanced Production Technologies of Oilseed Crops
Advanced Production Technology of Sugar Crops
Advanced Production Technologies of Potato
Advanced Production Technology and Processing of Jute
Tea production in Bangladesh: From bush to mug
Tea: a worthwhile, popular beverage crop since time immemorial
Agronomy of Betelvine Crop
Fundamentals of Crop Rotation in Agronomic Management
Cool Season Food Legumes in Rice Fallows: An Indian Perspective
Crop Diversification and Food Security
Fundamentals of Seed Production and Processing of Agronomic Crops
Seed Production Technologies of some Major Field Crops
Postharvest Technologies for Major Agronomic Crops.

Summary: Agronomic crops have provided food, beverages, fodder, fuel, medicine and industrial raw materials since the beginning of human civilization. More recently, agronomic crops have been cultivated using scientific rather than traditional methods. However, in the current era of climate change, agronomic crops are suffering from different environmental stresses that result in substantial yield loss. To meet the food demands of the ever-increasing global population, new technologies and management practices are being adopted to boost yields and maintain productivity under both normal and adverse conditions. Further, in the context of sustainable agronomic crop production, scientists are adopting new approaches, such as varietal development, soil management, nutrient and water management, and pest management. Researchers have also made remarkable advances in developing stress tolerance in crops. However, the search for appropriate solutions for optimal production to meet the increasing food demand is still ongoing. Although there are several publications on the recent advances in these areas, there are few comprehensive resources available covering all of the recent topics. This timely book examines all aspects of production technologies, management practices and stress tolerance of agronomic crops.

Contents:
Crop Rotation: Principles and Practices
Improving Water Use Efficiency in Agronomic Crop Production
Carbon Dioxide Enrichment and Crop Productivity
Soil Management for Better Crop Production and Sustainable Agriculture
Tillage Effects on Agronomic Crop Production
Alternate Wetting and Drying System for Water Management in Rice
Tools and Techniques for Nitrogen Management in Cereals
Biological Nitrogen Fixation in Nutrient Management
Use of Biofertilizers for Sustainable Crop Production
Organic Manuring for Agronomic Crops
Nitrogen Fixation in Nutrient Management
Weed Seed Bank
Impacts and Management for Future Crop Production
Weed Management for Healthy Crop Production
Integrated Weed Management for Agronomic Crops
Optimizing Herbicide Use in Herbicide-Tolerant Crops: Challenges, Opportunities, and Recommendations
Non-chemical Weed Management for Field Crops
Beneficial Effects of Weed Edophytic Bacteria: Diversity and Potentials of their Usage in Sustainable Agriculture
Pest Management for Agronomic Crops
Integrated Pest and Disease Management for Better Agronomic Crop Production
Green Manuring for Soil Health and Sustainable Production of Agronomic Crops
Plant-microbes Interactions in Agronomic Crops
Mycorrhiza in Sustainable Crop Production
The Role of Mucuna pruriens in Small Holder Farming Systems of Eastern and Southern Africa: A Review
Scientific Interventions to Improve Land and Water Productivity for Climate Smart Agriculture in South-Asia
Adaptation Strategies to Mitigate the Evapotranspiration for Sustainable Crop Production: A Perspective of Rice-Wheat Cropping System
Tools and Techniques of Post-harvest Processing of Food Grains and Seeds
Nanotechnology and its Role in Agronomic Crops
Role of ICT in Crop Management.

Summary: Agronomic crops have been a source of foods, beverages, fodders, fuels, medicines and industrial raw materials since the dawn of human civilization. Over time, these crops have come to be cultivated using scientific methods instead of traditional methods. However, in the era of climate change, agronomic crops are increasingly subjected to various environmental stresses, which results in substantial yield loss. To meet the food demands of the ever-increasing global population, new technologies and management practices are being adopted to boost yield and maintain productivity under both normal and adverse conditions. To promote the sustainable production of agronomic crops, scientists are currently exploring a range of approaches, which include varietal development, soil management, nutrient and water management, pest management etc. Researchers have also made remarkable progress in developing stress tolerance in crops through various approaches. However, finding solutions to meet the growing food demands remains a challenge. Although there are several research publications on the above-mentioned problems, there are virtually no comprehensive books addressing all of the recent topics. Accordingly, this book, which covers all aspects of production technologies, management practices, and stress tolerance of agronomic crops in a single source, offers a highly topical guide.

Contents:
Abiotic stress tolerance in field crops : integration of omics approaches / Zahide Neslihan Ozturk Gokce, Seyda Akbas, Sefa Ayten, M. Hussain Azimi, Reyhan Das, Saime Buse Guven et al.
Use of QTL in developing stress tolerance in agronomic crops / Ali Fuat Gökçe, Usman Khalid Chaudhry
Abiotic stress and applications of omics approaches to develop stress tolerance in agronomic crops / Subramani Pandian, Kasinathan Rakkammal, Arockiam Sagina Rency, Pandiyan Muthuramalingam, Shunmugiah Karutha Pandian, Manikandan Ramesh
The possible influence of climate change on agriculture / Sumera Shabir, Noshin Ilyas
Effect of agricultural pollution on crops / Fatima Bibi, Noshin Ilyas
Toxicity of soil hydrocarbon pollution in field crops and its remediation / Maimona Saeed, Noshin Ilvas
Drought and heat stress in cotton (Gossypium hirsutum L.) : consequences and their possible mitigation strategies / Ayman EL Sabagh, Akbar Hossain, Md. Sohidul Islam, Celaleddin Barutcular, Disna Ratnasekera, Ozgul Gormus et al.
Adverse effect of drought on quality of major cereal crops : implications and their possible mitigation strategies / Ayman EL Sabagh, Akbar Hossain, Celaleddin Barutçular, Mohammad Sohidul Islam, Zahoor Ahmad, Allah Wasaya et al. Growth and morphological changes of agronomic crops under abiotic stress / Aditi Shreeya Bali, Gagan Preet Singh Sidhu
Impact of climate variability on phenology of rice / Susmita Das, Adyant Kumar, Manashi Barman, Sukanta Pal, Pintoo Bandopadhyay
Abiotic stress responses and tolerance mechanisms for sustaining crop productivity in sugarcane / Sangeeta Srivastava, Pavan Kumar
Sugar beet : a sustainable crop for saline environment / Varucha Misra, A. K. Mall, A. D. Pathak
Agronomic crop responses and tolerance to drought stress / Seyed Yahya Salehi-Lisar, Hamideh Bakhshayeshan-Agdam
The response of major food crops to drought stress : physiological and biochemical responses / S. Bakht, K. Safdar, K. U. Khair, A. Fatima, A. Fayyaz, S. M. Ali et al.
Rice production, augmentation, escalation, and yield under water stress / U. Maalik, M. Farid, M. Zubair, S. Ali, M. Riwan, M. Shafqat et al.
Role of mineral nutrition in improving drought and salinity tolerance in field crops / Fahim Nawaz, Muhammad Asif Shehzad, Sadia Majeed, Khawaja Shafique Ahmad, Muhammad Aqib, Muhammad Munir Usmani et al.
Drought stress tolerance in legume crops / Savita, Ajay Tomer, Saurabh Kumar Singh
Drought tolerance : breeding efforts in sugarcane / A. K. Mall, Varucha Misra, B. D. Singh, Mukesh Kumar, A. D. Pathak
High-temperature response and tolerance in agronomic crops / Albert Maibam, Shabistana Nisar, Sajad Majeed Zargar, Reetika Mahajan
Agronomic crop responses and tolerance to metals/metalloids toxicity / Nadeem Iqbal, Nida Nazir, Muhammad Nauman, Malik Tahir Hayat, Waquar-un-Nisa
Arsenic contamination in major food crops : issues and mitigation in Indian subcontinent perspective / Sanchita Mondal, Puspendu Dutta, Pintoo Bandopadhyay, Srijani Maji Responses and tolerance of cereal crops to metal and metalloid toxicity / Iftikhar Ahmad, Muhammad Tahir, Umar Daraz, Allah Ditta, Muhammad Baqir Hussain, Zia Ul Haq Khan
Agronomic crop responses and tolerance to polycyclic aromatic hydrocarbon toxicity / Mahdieh Houshani, Seyed Yahya Salehi-Lisar
Gene pyramiding : an emerging control strategy against insect pests of agronomic crops / Muhammad Salim, Ayhan Gökçe, Muhammad Nadir Naqqash, Allah Bakhsh
Agronomic crops response and tolerance to allelopathic stress / Hamideh Bakhshayeshan-Agdam, Seyed Yahya Salehi-Lisar
Oxidative stress in crop plants / Arun Kumar Maurya
Herbicide resistance in crops and weeds / Zubair Aslam, Muhammad Saeed Ahmed, Safdar Bashir, Nabeel Khan, Zulfiqar Ahmad Saqib
Improving crop health and productivity : appraisal of induced mutations and advanced molecular genetic tools / Noor-ul-Huda Ghori, Tahir Ghori, Sameen Ruqia Imadi, Alvina Gul
Use of biostimulants to improve salinity tolerance in agronomic crops / Dell' Aversana Emilia, D' Amelia Luisa, De Pascale Stefania, Carillo Petronia
Abiotic stress tolerance in wheat and the role of silicon : an experimental evidence / Mukhtar Ahmed, Ummara Qadeer, Fayayz-ul-Hassan, Shah Fahad, Wajid Naseem, Saowapa Duangpan et al.
Molecular mechanisms associated with drought and heat tolerance in plants and options for crop improvement for combined stress tolerance / M. S. Parvathi, K. H. Dhanyalakshmi, K. N. Nataraja

Contents:
The cell and cell division / Margaret J Barch, Helen J Lawce
Cytogenetics: an overview / Helen J Lawce, Michael G Brown
Peripheral blood cytogenetic methods / Helen J Lawce, Michael G Brown
General cell culture principles and fibroblast culture / Debra F Saxe, Kristin M May, Jean H Priest
Prenatal chromosome diagnosis / Kristin M May, Debra F Saxe, Jean H Priest
Chromosome stains / Helen J Lawce
Human chromosomes: identification and variations / Helen J Lawce, Luke Boyd
ISCN: the universal language of cytogenetics / Marilyn S Arsham, Lisa G Shaffer
Constitutional chromosome abnormalities / Kathleen Kaiser-Rogers
Genomic imprinting / R Ellen Magenis
Cytogenetic analysis of hematologic malignant diseases / Nyla A Heerema
Cytogenetic methods and findings in human solid tumors / Marilu Nelson
Chromosome instability syndromes / Yassmine Akkari
Microscopy and imaging / Margaret J Barch, Helen J Lawce
Computer imaging / Christine E Haessig
Fluorescence in situ hybridization (FISH) / Helen J Lawce, Jeffrey S Sanford
Multicolor FISH (SKY and M-FISH) and CGH / Turid Knutsen
Genomic microarray technologies for the cytogenetics laboratory / Bhavana J Davé, Warren G Sanger
Mathematics for the cytogenetic technologist / Patricia K Dowling
Selected topics on safety, equipment maintenance, and compliance for the cytogenetics laboratory / Helen Jenks, Janet Krueger
A system approach to quality / Peggy J Stupca, Sheryl A Tran
Laboratory management / Mervat S Ayad, Adam Sbeiti
Laboratory information system / Peining Li, Richard Van Rheeden
Animal cytogenetics / Marlys L Houck, Teri L Lear, Suellen J Charter
Online genetic resources and references / Wahab A Khan.

Summary: "Artificial intelligence is rapidly and radically changing our lives and world. This book is a multidisciplinary engagement with the present and future impacts of AI from the standpoint of Christian faith. It provides technological, philosophical, and theological foundations for thinking about AI, as well as a series of reflections on the impact of AI on relationships, behavior, education, work, and moral action. The book serves as an accessible introduction to AI as well as a guide to wise consideration, design, and use of AI by examining foundational understandings and beliefs from a Christian perspective."-- Provided by publisher.

Contents:
Introduction / Michael J. Paulus
An introduction to artificial intelligence / Carlos R. Arias
What's so artificial and intelligent about artificial intelligence? : a conceptual framework for AI / Rebeka L.H. Rice
A theological framework for reflection on artificial intelligence / Michael D. Langford
Artificial intelligence and theological personhood / Michael D. Langford
Reinforcement in the information revolution / Phillip M. Baker
21st century learning skills and artificial intelligence / David Wicks, Michael J. Paulus / Automation, apocalypse : imagining the future of work / Michael J. Paulus
Sin and grace / Bruce D. Baker
Epilogue : A litany for faithful engagement with artificial intelligence.

Summary: The best source for cutting-edge insights into AI in healthcare operations AI in Healthcare: How Artificial Intelligence Is Changing IT Operations and Infrastructure Services collects, organizes and provides the latest, most up-to-date research on the emerging technology of artificial intelligence as it is applied to healthcare operations. Written by a world-leading technology executive specializing in healthcare IT, this book provides concrete examples and practical advice on how to deploy artificial intelligence solutions in your healthcare environment. AI in Healthcare reveals to readers how they can take advantage of connecting real-time event correlation and response automation to minimize IT disruptions in critical healthcare IT functions. This book provides in-depth coverage of all the most important and central topics in the healthcare applications of artificial intelligence, including: Healthcare IT AI Clinical Operations AI Operational Infrastructure Project Planning Metrics, Reporting, and Service Performance AIOps in Automation AIOps Cloud Operations Future of AI Written in an accessible and straightforward style, this book will be invaluable to IT managers, administrators, and engineers in healthcare settings, as well as anyone with an interest or stake in healthcare technology.

Summary: "Just months ago, millions of people were stunned by ChatGPT's amazing abilities, and its bizarre hallucinations. That was 2022. AI's next generation is coming fast : smarter, more accurate, with deeper technical knowledge. GPT-4 and its competitors are on the verge of transforming medicine. Whether you're a healthcare leader, provider, or a patient, you need to understand these technologies, stat. What can they do? What can't they do, yet? What shouldn't they ever do? To decide, experience the cutting edge for yourself. Join three insiders who've had months of early access to GPT-4 as they reveal its momentous potential ; to improve diagnoses, summarize patient visits, streamline processes, accelerate research, as well as its risks. You'll see real GPT-4 dialogues ; unrehearsed and unfiltered, brilliant and blundering alike, all annotated with invaluable context, candid commentary, real risk insights about potential downsides, and up-to-the-minute takeaways."-- taken from back cover.

Contents:
Foreword / by Sam Altman
First contact / by Peter Lee
Medicina ex machina / by Peter Lee
The big question : Does it “understand?” / by Peter Lee
Trust but verify / by Isaac "Zak" Kohane
The AI-augmented patient / by Carey Goldberg
So much more : Math, coding, and logic / by Peter Lee
The ultimate paperwork shredder / by Peter Lee
Smarter science / by Isaac "Zak" Kohane
Safety first / by Isaac "Zak" Kohane, Carey Goldberg, and Peter Lee
The big black bag / by Carey Goldberg and Isaac "Zak" Kohane
Epilogue / by Peter Lee.

Summary: "A trade book that argues that predictive AI is snake oil: it cannot and will never work. Artificial Intelligence is an umbrella term for a set of loosely related technologies. For instance, ChatGPT has little in common with algorithms that banks use to evaluate loan applicants. Both of these are referred to as AI, but in all of the salient ways - how they work, what they're used for and by whom, and how they fail - they couldn't be more different. Understanding the fundamental differences between AI technologies is critical for a technologically literate public to evaluate how AI is being used all around us. In this book, Arvind Narayanan and Sayash Kapoor explain the major strains of AI in use today: generative AI, predictive AI, and AI for content moderation. They show readers how to differentiate between them and, importantly, make a cogent argument for which types of AI can work well and which can never work, because of their inherent limitations. AI in this latter category, the authors argue, is AI snake oil: it does not and cannot work. More precisely, generative AI is imperfect but can be used for good once we learn how to apply it appropriately, whereas predictive AI can never work - in spite of the fact that it's being sold and marketed today in products - because we have never been able to accurately predict human behavior"-- Provided by publisher.

Summary: The United States has long been the leader in Artificial Intelligence. But Dr. Kai-Fu Lee--one of the world's most respected experts on AI--reveals that China has caught up to the US at an astonishingly rapid pace. As Sino-American competition in AI heats up, Lee envisions China and the US forming a powerful duopoly in AI. He outlines the upheaval of traditional jobs, how the suddenly unemployed will find new ways of making their lives meaningful, and how the Chinese and American governments will have to cope with the changing economic landscape. "Kai-Fu Lee--one of the world's most respected experts on AI and China--reveals that China has suddenly caught up to the United States at an astonishingly rapid and unexpected pace. In AI Superpowers, Kai-Fu Lee argues powerfully that because of the unprecedented developments in artificial intelligence, dramatic changes will be happening much sooner than many of us have expected. Indeed, as the U.S.-China competition in AI begins to heat up, Lee urges America and China to both accept and embrace the great responsibilities that come with significant technological power. Most experts already say that AI will have a devastating impact on blue-collar jobs. But Lee predicts that Chinese and American AI will have a strong impact on white-collar jobs as well. Is universal basic income the solution? In Lee's opinion, probably not. But he provides a clear description of which jobs will be affected and how soon, which jobs can be enhanced with AI, and, most important, how we can provide solutions to some of the most profound changes in human history that are coming soon."--Jacket.

Contents:
China's Sputnik moment
Copycats in the Coliseum
China's alternate Internet universe
A tale of two countries
The four waves of AI
Utopia, dystopia, and the real AI crisis
The wisdom of cancer
A blueprint for human co-existence with AI
Our global AI story.

Contents:
Introduction
Section I. Canada: Professionalization: Chapter 1: A Vital Response
Chapter 2: Treatment Rebellions
Section II. India: Techno-Bureaucracies: Chapter 3: Geographies of Intervention
Chapter 4: Documenting Sovereignty
Section III. Kenya: Bioexperimentalization
Chapter 5: A South-to-South Collaboration
Chapter 6:The Logic of Verification
Conclusion.

Summary: Peter Piot, founding executive director of the Joint United Nations Programme on HIV/AIDS (UNAIDS), recounts his experience as a clinician, scientist, and activist fighting the disease from its earliest manifestation to today. The AIDS pandemic was not only catastrophic to the health of millions worldwide but also fractured international relations, global access to new technologies, and public health policies in nations across the globe. As he struggled to get ahead of the disease, Piot found science does little good when it operates independently of politics and economics, and politics is worthless if it rejects scientific evidence and respect for human rights. Piot describes how the epidemic altered global attitudes toward sexuality, the character of the doctor-patient relationship, the influence of civil society in international relations, and traditional partisan divides. AIDS thrust health into national and international politics where, he argues, it rightly belongs. The global reaction to AIDS over the past decade is the positive result of this partnership, showing what can be achieved when science, politics, and policy converge on the ground. Yet it remains a fragile achievement, and Piot warns against complacency and the consequences of reduced investments. He refuses to accept a world in which high levels of HIV infection are the norm. Instead, he explains how to continue to reduce the incidence of the disease to minute levels through both prevention and treatment, until a vaccine is discovered. -- Publisher description.

Contents:
A heterogeneous and still-evolving epidemic
Hyperendemic HIV in Southern Africa : the heritage of apartheid
AIDS as an international political issue
A new type of transnational civil society movement
The right to treatment
Combination prevention
The economics of AIDS
Prominence of human rights
The long-term view.

Contents:
pt. 1. The Basic sciences
pt. 2. Clinical practice.

Contents:
pt. 1. Semeiology, specially designed for students preparing for examinations (1883 : 75 p.)
pt. 2. Physical (1881 : [2], 61 p.) / J.C. Thorowgood
pt. 3. What to ask (1882 : 66 p.).

Summary: "'Not a memoir, a biography, nor a reader. It is a reflection and a conversation. It is also a montage of forty years of documents, interviews and articles that provide useful lessons for social justice work' ... As an organizer, writer, publisher, scholar-activist and elected official, Barbara Smith has played key roles in multiple social justice movements, including Civil Rights, feminism, lesbian and gay liberation, anti-racism, and Black feminism. Her four decades of grassroots activism forged collaborations that introduced the idea that oppression must be fought on a variety of fronts simultaneously, including gender, race, class and sexuality. By combining ... historical documents with new unpublished interviews with fellow activists, this book uncovers the deep roots of today's 'identity politics' and 'intersectionality' and serves as an essential primer for practising solidarity and resistance"--Publisher's description.

Contents:
Chronicling an activist life
Home grown : early roots of activism
Building Black feminism
Building Black women's studies
Building Kitchen Table Press
Building multi-issue movements
Building progressive urban politics
"Took Root, Bore Fruit" : legacies and futures of a Black feminist life.

Contents:
1. Physiology of the Airway / Yoo Kuen Chan
2. Airway Assessment: A Critical Appraisal / Zahid H. Khan
3. Videolaryngoscopy and Indirect Intubating Aids in Airway Management / Sze-Ying Thong and Wendy H. L. Teoh
4. Perioperative Care of Ambulatory Anaesthesia / Anil Agarwal and Kamal Kishore
5. The Paediatric Airway: Normal and Abnormal / Ina Ismiarti Shariffuddin and Lucy Chan
6. Intubation of the Pediatric Patient / Josef Holzki
7. The Difficult Pediatric Airway: Management Options / Mahesh Vakamudi
8. Perioperative Management of Obstructive Sleep Apnea / Karen Mak and Edwin Seet
9. Airway Management in Traumatic Brain Injury (TBI) / Fauzia Anis Khan
10. Airway Management in Cervical Spine Injured Patients / Srikanth Sridhar and Carin A. Hagberg
11. Indigenous Devices in Difficult Airway Management / Virendra K. Arya
12. Cricothyrotomy / Virendra K. Arya
13. Surgical Airway / Jinbin Zhang and Orlando Hung
14. Surgical Approaches to Airway Management / Surender K. Malhotra
15. Difficult Airway in Obstetrics / Sunanda Gupta and Apoorva Gupta
16. Ultrasonography: Heralding a New Era in Airway Management / Michael Seltz Kristensen and Wendy H. L. Teoh.

Summary: "The AJCC Cancer Staging Manual is used by physicians and health care professionals throughout the world to facilitate the uniform description and reporting of neoplastic diseases. Proper classification and staging of cancer is essential for the physician to assign proper treatment, evaluate results of management and clinical trials, and to serve as the standard for local, regional and international reporting on cancer incidence and outcome. -- Significantly expanded and developed by international disease site expert panels, the Eighth Edition AJCC Cancer Staging Manual brings together all the currently available knowledge on staging of cancer at various anatomic sites. In this edition, evidence-based TNM staging is supplemented, as appropriate, by selected molecular markers and newly acquired insights into the molecular underpinnings of cancer. This edition features 12 entirely new staging systems, a wide range of changed or new staging definitions, and a refined emphasis on a personalized-medicine approach. To enhance the print and electronic usability of the cancer staging forms, they are now available exclusively for access and downloading at www.cancerstaging.org. -- The Eighth Edition AJCC Cancer Staging Manual remains the gold standard reference for oncologists, surgeons, pathologists, radiologists, cancer registrars and medical professionals world-wide to ensure that all those caring for cancer patients are fully versed in the language of cancer staging." -- from back of book.

Contents:
PART 1. General Information on Cancer Staging and End-Results Reporting
PART 2. Head and Neck
PART 3. Upper Gastrointestinal Tract
PART 4. Lower Gastrointestinal Tract
PART 5. Hepatobiliary System
PART 6. Neuroendocrine Tumors
PART 7. Thorax
PART 8. Bone
PART 9. Soft Tissue Sarcoma
PART 10. Skin
PART 11. Breast
PART 12. Female Reproductive Organs
PART 13. Male Genital Organs
PART 14. Urinary Tract
PART 15. Opthalmic Sites
PART 16. Central Nervous System
PART 17. Endocrine System
PART 18. Hematologic Malignancies.

Summary: This text provides a concise yet comprehensive overview of Alagille syndrome. The book reviews the pathophysiology and genetics of the disorder, discusses recent molecular advances and its impact on diagnostics, and describes management challenges and strategies. The text also touches upon future treatment options. Written by experts in the field, Alagille Syndrome: Pathogenesis and Clinical Management is a valuable resource for physicians and researchers dealing with this disorder, one that will help guide patient management and stimulate investigative efforts.

Summary: Albinism in Africa: Historical, Geographic, Medical, Genetic, and Psychosocial Aspects provides the first in-depth reference for understanding and treating patients of human albinism in Africa. Leading international contributors examine the historical, geographic, psychosocial, genetic and molecular considerations of importance in effectively and sensitively managing this genetic disorder. Foundational chapters covering the historical and psychosocial aspects of albinism are supplemented by discussions of the pathobiology of the disease, as well as a thorough analysis of the genetics of skin pigmentation, eye pigmentation, hair pigmentation, and incidents of skin cancer involved in the manifestations of this disorder. New prenatal diagnostics and genetic testing methods, genetic risk assessment for individuals, families, and communities, and novel genetic markers that may be used for developing new therapeutics for treating albinism are also discussed in detail. The book provides care management approaches that may be applied to instances of albinism in other regions, along with guiding principles for treating rare genetic disorders and stigmatized patient populations across the globe.

Contents:
1. Introduction and Historical Background / Jennifer G.R. Kromberg
2. Clinical Features, Types of Albinism, and Natural History / Jennifer G.R. Kromberg
3. Epidemiology of Albinism / Jennifer G.R. Kromberg
4. Prevalence and Population Genetics of Albinism: Surveys in Zimbabwe, Namibia, and Tanzania / Patricia M. Lund, Mark Roberts
5. Molecular Biology of Albinism / Prashiela Manga
6. Dermatological Aspects of Albinism / Sian Hartshorne, Prashiela Manga
7. Albinism and the Eye / Susan E.I. Williams
Chapter8. Low-Vision Rehabilitation and Albinism / Rebecca L. Kammer
9. Psychosocial and Cultural Aspects of Albinism / Jennifer G.R. Kromberg
10. Genetic Counseling and Albinism / Jennifer G.R. Kromberg
11. Genetic Testing, Postnatal, and Prenatal Diagnosis for Albinism / Robyn Kerr, Jennifer G.R. Kromberg
12. Albinism and Social Marginalization / Sam Clarke, Jon Beale
13. Interventions: Preventive Management, Empowerment, Advocacy, and Support Services / G.R. Kromberg
14. A Personal Perspective: Living With Albinism / Nomasonto G. Mazibuko, Jennifer G.R. Kromberg
15. Summary and Conclusion / Jennifer G.R. Kromberg, Prashiela Manga

Contents:
1. Alcohol a double-edged sword
2. Drugs of abuse
3. Designer drugs including bath salts and spices
4. Combined alcohol and drug abuse
5. Link between environmental factors, personality factors, and addiction
6. Genetic polymorphisms of alcohol metabolizing enzymes associated with protection from or increased risk of alcohol abuse
7. Pharmacogenomics of abused drugs
8. Association between polymorphisms in genes encoding various receptors, transporters, and enzymes and alcohol/drug addiction
9. Methods of alcohol measurement
10. Laboratory methods for measuring drugs of abuse in urine
11. Analysis of drug abuse in serum, hair, oral fluid, sweat and meconium.

Summary: "Following the Third Alcohol and Cancer Conference, this volume compiles the most up-to-date research on the role of alcohol consumption in carcinogenesis, from epidemiology to pathology metabolism and stem cells. More specifically, it delves into the effects of alcohol consumption and thyroid cancer, CD133+ progenitor cells, carcinogenic iron accumulation, developmental morphogens, and cancer-inducing epigenetic changes"--Publisher's description.

Contents:
Alcohol Consumption and Risk of Thyroid Cancer: A Population Based Case-Control Study in Connecticut
Roles of Cytochrome P450 in Metabolism of Ethanol and Carcinogens
Glutathione and Transsulfuration in Alcohol-associated Tissue Injury and Carcinogenesis
Fatty liver disease and hepatocellular carcinoma: The pathologist's view
Alcoholic liver disease accelerates early hepatocellular cancer in a mouse model
Chronic ethanol consumption and generation of etheno-DNA adducts in cancer-prone tissues
Role of TGF-β in Alcohol-Induced Liver Disease
NANOG-dependent metabolic reprogramming and symmetric division in tumor-initiating stem-like cells
Diet supplementation with soy protein isolate, but not the isoflavone genistein, protects against alcohol-induced tumor progression in DEN-treated male mice
ALDH1L1 and ALDH1L2 folate regulatory enzymes in cancer
Developmental Morphogens & Recovery from Alcoholic Liver Disease
Suppressed fat mobilization due to PNPLA3 rs738409 -associated liver damage in heavy drinkers: The liver damage feedback hypothesis
Aldo-Keto Reductases: Multifunctional Proteins as Therapeutic Targets in Diabetes and Inflammatory Disease
Engineered animal models designed for investigating ethanol metabolism, toxicity and cancer
Index.

Summary: "Alcohol is the most widely used drug in the world, yet alcoholism remains a serious addiction affecting nearly 20 million Americans. Our current understanding of alcohol's effect on brain structure and related functional damage is being revolutionized by genetic research, basic neuroscience, brain imaging science, and systematic study of cognitive, sensory, and motor abilities. Volume 125 of the Handbook of Clinical Neurology is a comprehensive, in-depth treatise of studies on alcohol and the brain covering the basic understanding of alcohol's effect on the central nervous system, the diagnosis and treatment of alcoholism, and prospect for recovery. The chapters within will be of interest to clinical neurologists, neuropsychologists, and researchers in all facets and levels of the neuroscience of alcohol and alcoholism"--Publisher's description.

Contents:
Section 1. Introduction
Alcoholism: diagnosis, prognosis, epidemiology, and burden of the disease / Thomas Beresford
Perspectives on the neuroscience of alcohol from the National Institute on Alcohol Abuse and Alcoholism / Kenneth Warren and Matthew Reilly
Section 2. Animal models: neurochemistry and metabolism of alcohol
Neurocircuitry of alcoholism: synthesis from animal models / George F. Koob
Metabolism / David Crabb and Martin Plawecki
Use of animal models of alcohol-related behavior / John C. Crabbe
Section 3. Molecular basis of alcoholism
Molecular basis of alcoholism / Dana Most, Laura Ferguson and R Adron Harris
Section 4. Neurological signs and consequences
Alcohol: intoxication and poisoning: diagnosis and treatment / Young-Chul Jung
Acute withdrawal: diagnosis and treatment / John CM Brust
Neurochemical mechanisms of alcohol withdrawal / Howard C. Becker
Molecular and neurological responses to chronic alcohol use / Michael F. Miles
Section 5. Neuropsychology
Methods of association and dissociation for establishing selective brain-behavior relations / Rosemary Fama and Edith V. Sullivan
Profiles of impaired, spared, and recovered neuropsychological processes in alcoholism / Marlene Oscar-Berman
Component processes of memory in alcoholism: pattern of compromise and neural substrates / Anne-Lise Pitel and Helene Beaunieux
Decision making, risky behavior, and alcoholism / George Fein
Motor systems and postural instability / Jessica Rose
Sex differences in alcohol-related neurobehavioral consequences / Sara Jo Nixon
Section 6. Neuroimaging of brain macrostructure and microstructure
Structural and microstructural imaging of the brain in alcohol use disorders / Natalie May Zahr
Section 7. Neuroimaging of neurochemical markers
Molecular imaging in alcohol dependence / Annisa Abi-Dargham
Brain proton magnetic resonance spectroscopy of alcohol use disorders / Dieter Meyerhoff
Section 8. Neuroimaging of brain function
Cognition, emotion, and attention / Tilman Schulte and Eva Muller-Oehring
The neurobiology of alcohol craving and relapse / Rajita Sinha
Compensatory recruitment of neural resources in chronic alcoholism / Sandra Chanraud
Section 9. Neuroelectrophysiology
Understanding alcohol use disorders with neuroelectrophysiology / Bernice Porjesz
Sleeping eeg / Ian Colrain
Section 10. Fetal alcohol spectrum disorder
Neurobehavioral, neurological, and neuroimaging characteristics of fetal alcohol spectrum disorders / Leila Glass, Ashley L. Ware and Sarah Mattson
Fetal alcohol spectrum disorder: pathogenesis and mechanisms / Kathleen Sulik
Current hypotheses on the mechanisms of alcoholism / Fulton Crews
Section 11. Adolescent drinking
The effect of alcohol use on human adolescent brain structures and systems / Susan F. Tapert
Section 12. Other topics
Peripheral systems: neuropathy / Robert O. Messing and Rajani Maiya
Pharmacological treatment of alcoholism / Raymond Francis Anton
Alcohol-medical drug interactions / Bankole A. Johnson and Chamindi Seneviratne
Genetics of alcoholism / Howard J. Edenberg
Co-occurring psychiatric disorders and alcoholism / J Stephen Rich and Peter R. Martin
Hepatic encephalopathy in alcoholic cirrhosis / Roger F. Butterworth
Neuropathology of alcoholism / Jillian Kril
Genetic differences in response to alcohol / Sachio Matsushita and Susumu Higuchi
Epidemiology of drinking, alcohol use disorders, and related problems / Raul Caetano, Patrice A.C. Vaeth, Karen Chartier and Britain A. Mills
Alcohol and the law / Michael J. Ostacher
Clinical management of alcohol use disorders in the neurology clinic / Anna Lembke and Mark Stanford.

Summary: In this book, new therapeutic approaches are comprehensively described, outlining the different interactions between personality, environment and the effects of the substance. In addition, the book provides a broad overview of the American and European epidemiology of alcohol and nicotine addictions. The book is written for all those who care for and offer professional therapy for alcohol and nicotine-addicted patients.

Summary: The book brings together the most up-to-date knowledge and expertise covering the whole topic of alcohol. It presents the practical skills needed to offer ethical intervention and treatment and implement ethical person-centered care. It is a practice-based text that aims to improve ethical relationships, responses, care and practice necessary to be effective in interventions and treatment with those experiencing alcohol use and health problems. The focus is on combining the principles and philosophy of alcohol prevention and intervention, in hospital and community. Each chapter provides self-assessment exercises, reflective practice exercises, key points and a "to learn more" section, and develops a theoretical framework, before broadening to include application in care and practice. This work will appeal to a wide readership, from professionals working within the mental health care and practice environment to mental health students.

Contents:
Section 1: Alcohol use: Introduction. Alcohol use. Ethical practice. Palliative care. Transcultural considerations. Lesbian, Gay, Bisexual, Transgender and Questioning. Mental health. Physical health
Section 2: Assessment: Referral. Response. Assessment. Adolescent and young adult
Female adult. Male adult. Older adult. Supporting the family. Binge drinking. Brief intervention
Section 3: Detoxification: Who needs detoxification. Assessment of risk in detoxification. Hospital detoxification. Home detoxification
Section 4: Treatment: Post-detoxification. Relapse. Motivational interviewing. End-of-life care
Section 5: Conclusion: The challenges ahead. Appendices.

Summary: Alcohol Use Disorders and the Lung: A Clinical and Pathophysiological Approach is an excellent resource for clinicians who care for individuals affected by alcohol use disorders in diverse settings. Although alcohol abuse alone does not cause acute lung injury, it renders the lung susceptible to dysfunction in response to the inflammatory stresses of sepsis, trauma, and other clinical conditions recognized to cause acute lung injury. In parallel, these same pathophysiological effects of alcohol abuse significantly increase the risk of a wide range of serious lung infections. Many clinicians involved in the primary treatment of alcohol use disorders, such as addiction psychiatrists, will find this text of interest as it will expand their understanding of the health consequences of alcohol use disorders. In parallel, clinicians who specialize in pulmonary and/or critical care medicine will have a unique resource that provides a comprehensive review of the pathophysiology of alcohol-related lung disorders and insights into evolving therapeutic options in these vulnerable individuals. Alcohol Use Disorders and the Lung: A Clinical and Pathophysiological Approach fills a gap in the literature and presents the evolving clinical research that may soon lead to novel therapies that can improve lung health in individuals with alcohol use disorders and co-existing conditions such as HIV infection.

Contents:
A Brief History of Alcohol Use and Abuse in Human History
Overview of the Evolving Recognition of the Health Effects of Excessive Alcohol Use Over the Past Two Centuries Including the Classic Citations
Current Definitions of Alcohol Use Disorders and the Use of Validated Questionnaires in Clinical Practice and Research
The Epidemiology of Alcohol Abuse and Pneumonia
The Epidemiology of Alcohol and Acute Respiratory Distress Syndrome
Alcohol, the Upper Airway, and Mucociliary Dysfunction in the Conducting Airways
Alcohol and the Alveolar Macrophage
Alcohol and the Alveolar Epithelium
Alcohol-Mediated Oxidative Stress in the Airway: The Unique Role of Thiol Depletion
Alcohol and the Adaptive Immune Response in the Airway: Dendritic Cell and Lymphocyte Impairments
Alcohol Impairment of Granulocyte Function During Lung Infection
Disruption in the Dynamic Balance Between Transforming Growth Factor- and Granulocyte/Macrophage Colony-stimulating Factor Signaling within the Alveolar Space of the Alcoholic Lung: Impact on Epithelial and Macrophage Function
Alcohol-mediated Zinc Deficiency within the Alveolar Space: A Potential Fundamental Mechanism Underlying Oxidative Stress and Cellular Dysfunction in the Alcoholic Lung
The Impact of Alcohol Abuse on Multiple Organ Dysfunction in the Surgical Patient
Alcohol and HIV: Experimental and Clinical Evidence of Combined Impact on the Lung
Maternal Alcohol Use and the Neonate.

Summary: This book describes the latest advances concerning the molecular mechanisms of and therapeutic strategies for alcohol- and non-alcohol-related digestive diseases. Alcohol abuse causes not only liver injury but can harm various organs, resulting in esophageal and colorectal cancers, GERD, pancreatitis, etc. Similar to alcoholic abuse, metabolic syndrome based on obesity and diabetes is also strongly associated with the development of various digestive diseases. Although these diseases may be differentiated by the presence or absence of alcohol intake, the pathologic findings and pathogenesis reveal a number of similarities. This volume covers clinical and basic approaches for esophageal, gastric, hepatic, colorectal and pancreatic diseases associated with alcohol abuse and metabolic syndrome; further, it discusses the roles of microbiota, oxidative stress, and apoptosis, the critical factors causing alcoholic and metabolic digestive diseases. Also, it showcases new pathological and therapeutic perspectives in gastric and pancreatic cancers. Alcoholic/Non-Alcoholic Digestive Diseases will provide invaluable information for doctors specializing in gastroenterology and hepatology and researchers seeking new research on digestive diseases based on alcohol consumption and obesity.

Contents:
v. 1. Final report
v. 2. Alcohol abuse and alcoholism
v. 4. Summary of Federal and state alcoholism programs.

Summary: Fully revised and updated based on valuable reader feedback, Aldeen and Rosenbaum's 1200 Questions to Help You Pass the Emergency Medicine Boards, Third Edition gives you the tools you need to pass the ABEM board exam on the first try. Questions are slightly more difficult than the average exam question, in order to challenge and add to your knowledge and fully prepare you for questions you're likely to see. Every question in this Third Edition has been reviewed for quality and relevance, ensuring that this unique study tool is an ideal choice to prepare for both the in-service residency exam and the board exam in emergency medicine.

Summary: This volume covers the science of ALDH enzymes in relation to chronic disease processes and the future therapeutic potentials of targeting ALDH in these processes. It thoroughly reviews the roles of ALDH family in alcohol metabolism, as well as recent findings of their emerging roles in a variety of human pathologies such as cardiovascular diseases, diabetes, obesity, stroke, cancer, liver diseases and kidney diseases. Delicate contribution of ALDH enzymes in the therapeutics against chronic diseases is also discussed. It demonstrates the unique value of targeting genetic polymorphism in ALDH enzymes in personalized medicine. The book will appeal to scientists, physicians, graduate and professional students in the fields of ALDH enzymes, alcohol metabolism, cardiometabolic and other chronic diseases. Pharmaceutical and other companies developing new tools for cardiometabolic and chronic diseases treatment will also find this a valuable resource.

Contents:
1. Role of alcohol oxidative metabolism in its cardiovascular and autonomic effects
2. Environmental aldehyde sources and the health implications of exposure
3. ALDH2 and cardiovascular disease
4. Aldehyde dehydrogenases: From alcohol metabolism to human health and precision medicine
5. Aldehyde dehydrogenase 2 and heart Failure
6. Mitochondrial aldehyde dehydrogenase in myocardial ischemic and ischemia-reperfusion injury
7. East Asian variant aldehyde dehydrogenase 2 genotype (ALDH2*2*) contributes to coronary artery spasm and acute myocardial infarction
8. Aldehyde dehydrogenases genetic polymorphism and obesity: from genomics to behavior and health
9. Aldehyde dehydrogenase (ALDH) 2 in diabetic heart diseases
10. The role of ALDH2 in sepsis and the to-be-discovered mechanisms
11. ALDH2 and stroke
12. ALDH2 and hypertension
13. ALDH2 and cancer therapy
14. ALDH2 polymorphism and ethanol consumption: A genetic-environmental interaction in carcinogenesis
15. ALDH2 and aging.

Summary: Aleocharine beetles are among the most poorly known and difficult-to-identify groups of Coleoptera worldwide. This book presents the first comprehensive synopsis of aleocharine rove beetle species (Coleoptera, Staphylinidae) from British Columbia, Canada. It is important to generate a structured inventory of species in hotspots of biodiversity like British Columbia, to provide baseline biodiversity data for monitoring species responses related to climate change. It is the first book to treat and illustrate every recorded and new species. For every species, color illustrations are provided, including color habitus and genital diagnostic structures of both sexes. Two hundred and twenty-seven valid species, including 14 new species, 16 new generic records, and 36 (excluding new species) new provincial and 6 state records, in 79 genera and 14 tribes.Tribes and subtribes are arranged in phylogenetic order as it is currently recognized, and genera and subgenera are listed alphabetically within each tribe or subtribe. Species are listed alphabetically or in species groups to better reflect their relationships. Species distribution is listed by provinces and territories in Canada and states in the United States, and the geographic origin of each species is categorized as native, Holarctic, adventive or undetermined (either adventive or Holarctic). Every species is presented with a morphological diagnosis including external and genital characters of both sexes. Collection and habitat data are presented for each species, including collecting period, and collecting methods. A list of all eastern Canadian species with their currently known distribution in North America is presented at the end of the book. -- Provided by publisher.

Contents:
Introduction
Prominent forebearers of modern Aleocharine systematics in North America
Historical review of research on Aleocharinae in Canada, with a focus on British Columbia
Material and methods
British Columbia : hotspot of Canadian biodiversity
Faunal analysis and discussion
List of recorded species of British Columbian Aleocharinae and their composition
Key to tribes of Aleocharine and their composition
Key to tribes of Aleocharine occurring in British Columbia
Tribe Gymnusini Heer, 1839
Tribe Aleocharini Fleming, 1821
Tribe Oxypodini C.G. Thomson, 1859
Tribe Tachyusini C.G. Thomson, 1859
Tribe Hypocyphtini Laporte, 1835
Tribe Myllaenini Ganglbauer, 1895
Tribe Diglottini Jakobson, 1909
Tribe Liparocephalini Fenyes, 1918
Tribe Autaliini C.G. Thomson, 1859
Tribe Homalotini Heer, 1839
Tribe Placusini Mulsant and Rey, 1871
Tribe Athetini Casey, 1910
Tribe Falagriini Mulsant and Rey, 1873
Tribe Lomechusini Fleming, 1821.