BookPhilip Rubin, Louis S. Constine, Lawrence B. Marks, editors.
Summary: The literature on the late effects of cancer treatment is widely scattered in different journals since all major organ systems are affected and management is based on a variety of medical and surgical treatments. The aim of ALERT Adverse Late Effects of Cancer Treatment is to offer a coherent multidisciplinary approach to the care of cancer survivors. The central paradigm is that cytotoxic multimodal therapy results in a perpetual cascade of events that affects each major organ system differently and is expressed continually over time. Essentially, radiation and chemotherapy are intense biologic modifiers that allow for cancer cure and cancer survivorship but accelerate senescence of normal tissues and increase the incidence of age-related diseases and second malignant tumors. Volume 1 of this two-volume work focuses on the general concepts and principles relevant to late effects and on the dynamic interplay of molecular, cytologic and histopathologic events that lead to altered physiologic and metabolic functions and their clinical manifestations. Chapters are also included on legal issues, economic aspects, nursing, psychological issues and quality of life.
Contents:
Prologue : Surviving cancer : SEER statistics
Biobontinuum of the pathophysiology paradigm
Biophysiopathology of the microvascular and microcirculation
Molecular mechanisms of radiation induced therapy
Biodetection and biointervention : cytokine pathways as a rationale for anti-cytokine interventions post-radiation
Quantitative/objective analyses of RT-induced late normal tissue injury using functional imaging
Biograding of normal tissue TNM toxicity taxonomy : scoring the adverse effects of of cancer treatment
Understanding and predicting radiation-associated normal tissue injury : a global and history perspective
Biotoxity of chemotherapy
BioSurveillance and longitudinal lifelong guidelines
BioPediatric complexities of growth and development
BioGenetic and host implications
Bioengineering of irradiated normal tissues by bone marrow stem cells
Radiotherapy-induced carcinogenesis and Leukemogenesis : mechanisms and quantitative moeling
The bioepidemiology of MultiplePrimary cancers
Radiation-related second primary cancers : clinical perspectives
The psychosocial and functional impact of radiation therapy
Nursing
Economic consequences of late effects
Radiological and nuclear terrorism : relevance to the radiation oncology and biology communities.