BookGyan Prakash, Takeshi Iwata, editors.
Summary: This book presents the state of the art in genetic eye research in Asia and the Pacific. Though there has been an explosion of information on genetic eye research in western countries, more than sixty percent of the human genes involved in eye diseases in the Asian and Pacific population remain unknown. However, new efforts and a new awareness have sparked important discussions on the subject, and new plans are being implemented to discover the genes responsible for many eye diseases in the population. The book reviews the latest findings; its content ranges from genetic aspects of human migration to DNA sequence analysis, genome-wide association analysis, and disease phenotypes. The efforts of the Asian Eye Genetic Consortium (AEGC) are also discussed. The book's editors have been instrumental in developing strategies for discovering the new Asian genes involved in many eye diseases. All chapters were written by leading researchers working on Asian eye genetics from the fields of Human Genetics, Ophthalmology, Molecular Biology, Biochemistry, Sensory Sciences, and Clinical Research. Advances in Vision Research, Volume I will prove to be a major resource for all researchers, clinicians, clinical researchers, and allied eye health professionals with an interest in eye diseases among the Asian population.
Contents:
1. Asian eye genetics consortium (AEGC)
2. Japan eye genetics consortium (JEGC) for hereditary retinal diseases
3. Whole genome sequencing in genetic eye diseases
4. Targeted exome sequencing in japanese patients with retinitis pigmentosa
5. Genetic epidemiology of congenital cataracts and autosomal recessive retinal degenerations in Pakistan
6. Genetics of cataract in Asia: an overview of research in congenital and age-related cataract with emphasis on Indian population
7. genetic analysis of families with retinal dystrophies
8. Whole genome sequencing in patients with rretinitis pigmentosa
9. Retinitis pigmentosa in Korean patients
Retinitis pigmentosa in China
11. Retinitis pigmentosa in Japanese population
12. Cone dysfunction syndrome in the Japanese population
13. Leber Congenital amaurosis/early-onset retinal dystrophy in Japanese population
14. Paradigm of susceptibility genes in AMD and PCV
15. Genetics and pathology of inflammatory components on AMD
16. Genome-wide association study of age-related eye diseases in Chinese population
17. Clinical genetics of retinoblastoma: an Asian perspective
18. Molecular and clinical genetics of retinoblastoma
19. Current research perspectives in understanding diabetic retinopathy
20. Genome-wide association studies of glaucoma
21. Genetic complexity of primary angle-closure glaucoma in asians
22. Genotype-phenotype correlation for POAG in the Middle East and other populations
23. Corneal dystrophies in India
24. Genetics of corneal endothelial dystrophies: an Asian perspective
25. Keratoconus in Asia
26. Genetics of pediatric eye diseases and strabismus in Asia
27. Keratoconus: globally and in the Middle East (epidemiology, genetics, and future research)
28. Genetics of myopia
29. Ocular implications of gaucher disease
30. Genetic background of uveitis in chinese population
31. Usher syndrome in Chinese and Japanese population
32. Homozygosity mapping for autosomal recessive ocular diseases
33. Tools of genetic eye research and need for clinical research collaborations
34. Eye genetics: the road ahead to quality standards
35. Genetic counseling in Asia
36. Epigenetic study in asian eye diseases
37. Unique genetic signatures in Asian age-related macular degeneration: an opportunity for drug development
38. A perspective: how gene therapeutics can help address global health issues.