BookAlisa G. Woods, Costel C. Darie, editors.
Summary: This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease, and psychiatry. Additional chapters focus on methodology, technologies and instrumentation, as well as on analysis of protein-protein interactions, protein quantitation, and protein post-translational modifications. Various omics fields such as proteomics, metabolomics, glycomics, lipidomics, and adductomics are also covered. Applications of mass spectrometry in biotechnological and pharmaceutical industry are also discussed. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research, but also to initiate and improve their own work. This book acts as a technical guide as well as a conceptual guide to the newest information in this exciting field.
Contents:
Mass Spectrometry for Proteomics-based Investigation
MALDI profiling and applications in medicine
Applications of Matrix-Assisted Laser Desorption Ionization In-Source Decay Mass Spectrometry
Proteome imaging: from classic to modern mass spectrometry-based molecular histology
Mass Spectrometry-Based Tissue Imaging of Small Molecules
Sequencing Proteins from Bottom to Top: Combining Techniques for Full Sequence Analysis of Glucokinase
Proteomics and non-proteomics approaches to study stable and transient protein-protein interactions
Contribution of Mass spectrometry-based Proteomics to Discoveries in Developmental Biology
Profiling optimal conditions for capturing EDEM proteins complexes in melanoma using mass spectrometry
The Methods employed in Mass Spectrometric Analysis of Posttranslational Modifications (PTMs) and Protein-Protein Interactions (PPIs)
Identification of post-translational modifications (PTMs) of proteins by mass spectrometry
Sequence Variant and Post-translational Modification Analysis During Cell Line Selection via High-throughput Peptide Mapping
Selective derivatization of hexahistidine-tagged recombinant proteins
Investigation of Antibody-Drug Conjugates by Mass Spectrometry
Mass Spectrometry- and Computational Structural Biology-Based Investigation of Proteins and Peptides
Strategies for Membrane Protein Analysis by Mass Spectrometry
The Potential for Ion Mobility in Pharmaceutical and Clinical Analyses
Application of Ion Mobility Mass Spectrometry in Lipidomics
Mass Spectrometry in Advancement of Redox Precision Medicine
Applications for mass spectrometry in the study of ion channel structure and function
Immuno
affinity Mass Spectrometry: A Novel Approaches with Biomedical Relevance
Developing well-annotated species-specific protein databases using comparative proteogenomics
Stoichiometry of heavy metal binding to peptides involved in Alzheimer's disease: mass spectrometric evidence
Role of mass spectrometry in investigating a novel protein: the example of Tumor Differentiation Factor (TDF)
Mass Spectrometry-Based Biomarkers in Drug Developmen
Combinatorial Electrophoresis and Mass Spectrometry-Based Proteomics in Breast Milk for Breast Cancer Biomarker Discovery
Proteomic approaches to dissect neuronal signalling pathways
Mass Spectrometry for the Study of Autism and Neurodevelopmental Disorders
Simplifying the proteome: Analytical strategies for improving peak capacity
Exploration of nicotine metabolism in Paenarthrobacter nicotinovorans pAO1 by microbial proteomics
Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) for Quantitative Proteomics
Mass spectrometry based comparative proteomics using one dimensional and two dimensional SDS-PAGE of rat atria induced with obstructive sleep apnea
2D SDS PAGE in combination with western blotting and mass spectrometry is a robust method for protein analysis with many applications
Pulse SILAC approaches to the measurement of cellular dynamics
Protein Biomarkers in Major Depressive Disorder: an Update
A Pilot Exploratory Proteomics Investigation of Mental Fatigue and Mental Energy
Metabolomics and biomarker discovery
Analytical Methods for Mass Spectrometry-Based Metabolomics Studies
Trends in analysis of cortisol and its derivatives
Detection of biomedically relevant stilbenes from wines by mass spectrometry
Mass spectrometry as a complementary approach for noncovalently bound complexes based on cyclodextrins
Trends in glycolipid biomarker discovery in neurodegenerative disorders by mass spectrometry
Non-targeted Screening in Environmental Monitoring Programs
Mass Spectrometric DNA Adduct Quantification by Multiple Reaction Monitoring and its Future Use for the Molecular Epidemiology of Cancer
Bottlenecks in proteomics: an update
Recent Applications of Mass Spectrometry at Clarkson University
Index.