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  • Book
    Alisa G. Woods, Costel C. Darie, editors.
    Summary: This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease, and psychiatry. Additional chapters focus on methodology, technologies and instrumentation, as well as on analysis of protein-protein interactions, protein quantitation, and protein post-translational modifications. Various omics fields such as proteomics, metabolomics, glycomics, lipidomics, and adductomics are also covered. Applications of mass spectrometry in biotechnological and pharmaceutical industry are also discussed. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research, but also to initiate and improve their own work. This book acts as a technical guide as well as a conceptual guide to the newest information in this exciting field.

    Contents:
    Mass Spectrometry for Proteomics-based Investigation
    MALDI profiling and applications in medicine
    Applications of Matrix-Assisted Laser Desorption Ionization In-Source Decay Mass Spectrometry
    Proteome imaging: from classic to modern mass spectrometry-based molecular histology
    Mass Spectrometry-Based Tissue Imaging of Small Molecules
    Sequencing Proteins from Bottom to Top: Combining Techniques for Full Sequence Analysis of Glucokinase
    Proteomics and non-proteomics approaches to study stable and transient protein-protein interactions
    Contribution of Mass spectrometry-based Proteomics to Discoveries in Developmental Biology
    Profiling optimal conditions for capturing EDEM proteins complexes in melanoma using mass spectrometry
    The Methods employed in Mass Spectrometric Analysis of Posttranslational Modifications (PTMs) and Protein-Protein Interactions (PPIs)
    Identification of post-translational modifications (PTMs) of proteins by mass spectrometry
    Sequence Variant and Post-translational Modification Analysis During Cell Line Selection via High-throughput Peptide Mapping
    Selective derivatization of hexahistidine-tagged recombinant proteins
    Investigation of Antibody-Drug Conjugates by Mass Spectrometry
    Mass Spectrometry- and Computational Structural Biology-Based Investigation of Proteins and Peptides
    Strategies for Membrane Protein Analysis by Mass Spectrometry
    The Potential for Ion Mobility in Pharmaceutical and Clinical Analyses
    Application of Ion Mobility Mass Spectrometry in Lipidomics
    Mass Spectrometry in Advancement of Redox Precision Medicine
    Applications for mass spectrometry in the study of ion channel structure and function
    Immuno
    affinity Mass Spectrometry: A Novel Approaches with Biomedical Relevance
    Developing well-annotated species-specific protein databases using comparative proteogenomics
    Stoichiometry of heavy metal binding to peptides involved in Alzheimer's disease: mass spectrometric evidence
    Role of mass spectrometry in investigating a novel protein: the example of Tumor Differentiation Factor (TDF)
    Mass Spectrometry-Based Biomarkers in Drug Developmen
    Combinatorial Electrophoresis and Mass Spectrometry-Based Proteomics in Breast Milk for Breast Cancer Biomarker Discovery
    Proteomic approaches to dissect neuronal signalling pathways
    Mass Spectrometry for the Study of Autism and Neurodevelopmental Disorders
    Simplifying the proteome: Analytical strategies for improving peak capacity
    Exploration of nicotine metabolism in Paenarthrobacter nicotinovorans pAO1 by microbial proteomics
    Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) for Quantitative Proteomics
    Mass spectrometry based comparative proteomics using one dimensional and two dimensional SDS-PAGE of rat atria induced with obstructive sleep apnea
    2D SDS PAGE in combination with western blotting and mass spectrometry is a robust method for protein analysis with many applications
    Pulse SILAC approaches to the measurement of cellular dynamics
    Protein Biomarkers in Major Depressive Disorder: an Update
    A Pilot Exploratory Proteomics Investigation of Mental Fatigue and Mental Energy
    Metabolomics and biomarker discovery
    Analytical Methods for Mass Spectrometry-Based Metabolomics Studies
    Trends in analysis of cortisol and its derivatives
    Detection of biomedically relevant stilbenes from wines by mass spectrometry
    Mass spectrometry as a complementary approach for noncovalently bound complexes based on cyclodextrins
    Trends in glycolipid biomarker discovery in neurodegenerative disorders by mass spectrometry
    Non-targeted Screening in Environmental Monitoring Programs
    Mass Spectrometric DNA Adduct Quantification by Multiple Reaction Monitoring and its Future Use for the Molecular Epidemiology of Cancer
    Bottlenecks in proteomics: an update
    Recent Applications of Mass Spectrometry at Clarkson University
    Index.
    Digital Access Springer 2019