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  • Book
    Benjamin F. Cravatt, Ku-Lung Hsu, Eranthie Weerapana, editors.
    Summary: "This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions."--Publisher's description.

    Contents:
    Activity-based protein profiling- enabling multimodal functional studies of microbial communities
    Activity-based protein profiling methods to study bacteria: the power of small-molecule electrophiles
    Opportunities and challenges in activity-based protein profiling of mycobacteria
    Activity-based protein profiling at the host-pathogen interface
    Chemical proteomic profiling of protein fatty-acylation in microbial pathogens
    How to target viral and bacterial effector proteins interfering with ubiquitin signaling
    ABPP and host-virus interactions
    Activity-based protein profiling for the study of parasite biology
    Deciphering T cell immunometabolism with activity-based protein profiling
    Small-molecular inhibitors of PARPs: from tools for investigating ADP-ribosylation to therapeutics
    Development of activity-based proteomic probes for protein citrullination
    Recent advances in activity-based protein profiling of proteases
    Opportunities for lipid-based probes in the field of immunology
    Activity-based protein profiling of non-ribosomal peptide synthetases
    Target identification of bioactive covalently acting natural products
    Applications of reactive cysteine profiling.
    Digital Access Springer 2019