BookWalter Isaacson.
Summary: "When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback, titled The Double Helix, on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the building blocks of life. Even though her high school counselor told her girls didn't become scientists, she decided she would. Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book's author, James Watson, told her was the most important biological advance since his codiscovery of the structure of DNA. She and her collaborators turned their curiosity into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for COVID-19 will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution: children who study digital coding will be joined by those who study the code of life. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful book that would be! And what about preventing depression? Hmm...should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species"--From dust jacket.
Contents:
Introduction. Into the breach
Part one. The origins of life. Hilo ; The gene ; DNA ; The education of a biochemist ; The human genome ; RNA ; Twists and folds ; Berkeley
Part two. CRISPR. Clustered repeats ; The Free Speech Movement Café ; Jumping in ; The yogurt makers ; Genentech ; The lab ; Caribou ; Emmanuelle Charpentier ; CRISPR-Cas9 ; Science, 2012 ; Dueling presentations
Part three. Gene editing. A human tool ; The race ; Feng Zhang ; George Church ; Zhang tackles CRISPR ; Doudna joins the race ; Photo finish ; Doudna's final sprint ; Forming companies ; Mon amie ; The heroes of CRISPR ; Patents
Part four. CRISPR in action. Therapies ; Biohacking ; DARPA and anti-CRISPR
Part five. Public scientist. Rules of the road ; Doudna steps in
Part six. CRISPR babies. He Jiankui ; The Hong Kong summit ; Acceptance
Part seven. Moral questions. Red lines ; Thought experiments ; Who should decide? ; Doudna's ethical journey
Part eight. Dispatches from the front. Quebec ; I learn to edit ; Watson revisited ; Doudna pays a visit
Part nine. Coronavirus. Call to arms ; Testing ; The Berkeley lab ; Mammoth and Sherlock ; Coronavirus tests ; Vaccines ; CRISPR cures ; Cold Spring Harbor virtual ; The Nobel Prize.
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