BookMark R. Litzow, Elizabeth A. Raetz, editors.
Summary: This book provides a state-of-the-art overview of acute lymphoblastic leukemia (ALL). The first section of the book presents the translational science behind ALL, reviewing molecular pathways and targets in B- and T-cell ALL, as well as techniques and application of minimal residual disease testing. The second section spotlights ALL management strategies for patients across the spectrum, from infants to the elderly. The final section outlines current and new advances in ALL treatment, including new monoclonal antibodies and allogenic and autologous HSCT. Written by experts in the field, Clinical Management of Acute Lymphoblastic Leukemia: From Bench to Bedside is a valuable resource that will guide patient management, stimulate investigative efforts, and increase understanding of the biologic underpinnings of the disease.
Contents:
TRANSLATIONAL SCIENCE
Molecular pathways and targets in B cell progenitor acute lymphoblastic leukemia
Genetic Mechanisms in T-Cell Acute Lymphoblastic Leukemia
Minimal Residual Disease in Acute Lymphoblastic Leukemia : Techniques and Application
THERAPEUTICS
Treatment of Pediatric B and T cell ALL
Treatment of Adult B and T cell Acute Lymphoblastic Leukemia: An Overview of Current Treatments and Novel Advances
Acute Lymphoblastic Leukemia in Infants: A distinctive, high risk subtype of childhood ALL
Treatment of Elderly Patients with Acute Lymphoblastic Leukemia
Treatment of Childhood Philadelphia-Chromosome Positive Acute Lymphoblastic Leukemia
Treatment of adult Philadelphia chromosome positive ALL
Treatment of Ph-like ALL
Prophylaxis and treatment of central nervous system (CNS) ALL
Late effects of therapy of acute lymphoblastic leukemia
NEW AND EXISTING MODALITIES OF THERAPY
Monoclonal Antibody Based Treatment and Other New Agents for B-Lineage ALL
New Agents for the Treatment of T-Cell ALL
The development and management of treatment with chimeric-antigen receptor T cell (CAR-T)
Hematopoietic Stem Cell Transplantation in Adults with Acute Lymphoblastic Leukemia (ALL)
Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia.