Bookedited by Robert N. Taylor, Kirk P. Conrad, Sandra T. Davidge, Anne Cathrine Staff, James M. Roberts.
Summary: Leon Chesley's Hypertensive Disorders in Pregnancy was initially published in 1978. Four decades later, hypertension complications in pregnancy are still a major cause of fetal and maternal morbidity and death, especially in less developed nations. It is also a leading cause of preterm birth now known to be a risk factor in remote cardiovascular disease. Despite this, hypertensive disorders remain marginally studied and management is often controversial. Chesley's Hypertensive Disorders in Pregnancy, Fifth Edition continues its tradition as one of the beacons to guide the field of preeclampsia research, recognized for its uniqueness and utility. This revision focuses on prediction, prevention, and management for clinicians, and is an essential reference text for clinical and basic investigators alike. It provides a superb analysis of the multiple topics that relate to hypertension in pregnancy, especially of preeclampsia.
Contents:
The spectrum of hypertensive disorders in pregnancy: Dr. Leon Chesley's legacy
Epidemiology of hypertensive disorders in pregnancy
Genetic factors in the etiology of preeclampsia/eclampsia
Preconceptional and periconceptional pathways to preeclampsia
Placentation and placental function in normal and preeclamptic pregnancies
Unbiased approaches for addressing the complexities of the placenta's role in the preeclampsia syndrome
The immunology of preeclampsia
Trophoblast extracellular vesicles in preeclampsia
Angiogenesis and preeclampsia
Vascular endothelial cell dysfunction in preeclampsia
Cardiovascular alterations in normal and preeclamptic pregnancy
Cardiometabolic antecedents of preeclampsia
Cerebrovascular pathophysiology in preeclampsia and eclampsia
The kidney in normal pregnancy and preeclampsia
Salt, aldosterone, and the renin-angiotensin system in pregnancy
Platelets, coagulation, and the liver
Clinical management and antihypertensive treatment of hypertensive disorders of pregnancy
Prediction and prevention of preeclampsia
Long-term effects of preeclampsia on mothers and offspring
Animal models used for investigating pathophysiology of preeclampsia and identifying therapeutic targets
Harmonization of data and biobanks for preeclampsia research.