BookRichard J. Cote, Ram H. Datar, editors.
Contents:
Preface
Foreword
Section I. Technologies for CTC Identification
1. Significance of Studying Circulating Tumor Cells
2. Affinity-Based Enrichment of Circulating Tumor Cells
3. Size-Based and Non-Affinity Based Microfluidic Devices for Circulating Tumor Cell Enrichment and Characterization
4. Molecular Assays for the Detection and Molecular Characterization of CTCs
5. Cancer Stem Cells and Circulating Tumor Cells Molecular Markers, Isolation Techniques and Clinical Implications
Section II. Fundamental Studies of CTC
6. Circulating Tumor Cells and Tumor Dormancy.- 7. Prevention of Conversion of Tumor Dormancy into Proliferative Metastases
8. Genesis of Circulating Tumor Cells through Epithelial-Mesenchymal Transition as a Mechanism for Distant Dissemination
Section III. CTC Analysis
9. CTC Analysis FISH, ISH, Array-CGH and Other Molecular Assays
10. Genome-Wide Gene Copy Number Analysis of Circulating Tumor Cells
11. Perspectives on the Functional Characterization and In Vitro Maintenance of Circulating Tumor Cells
12. Prognostic Implications of CTC in Breast Cancer
Section IV. Potential Clinical Applications of CTC
13. CTC in Advanced Breast Cancer Prognosis, Monitoring and Clinical Utility
14. Evolution of Metastatic Disease: The Need for Monitoring and Emerging Therapeutic Opportunities
15. CTC for Biomarker and Companion Diagnostic Development
16. Perspectives on Clinical Applications of CTCs
Index.