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  • Digital
    Vinood B. Patel, Victor R. Preedy, Rajkumar Rajendram, editors.
    Springer2016
    Section 1: Basic Processes at the Cellular Levels -- Arginine uptake by cells -- L-arginine and the expression of HSP70 and p-53 proteins -- AMP-activated protein kinase and L-arginine -- Amidine-based compounds affecting arginine metabolism -- Oxy- and sulfoanalogues of L-arginine -- Regulation of expression and activity of L-arginine transporters by nutrients and hormones: A focus in transcriptional mechanisms regulated by glucose and insulin -- Arginine, pancreatic beta cell function and diabetes: mechanisms of stimulated insulin release and pathways of metabolism -- Erythrocytes by-products of arginine catabolism -- Section 2: Arginine Metabolism and Functions -- Arginine synthesis from enteral proline -- Arginine and macrophages: role in classical and alternative activation -- Arginine and TNF alpha production in macrophages: a focus on metabolism, ageing, metabolic syndrome and type 2 diabetes -- Arginine metabolism impairment during sepsis and diseases: causes and consequences -- Use of arginine with Growth Hormone Releasing Hormone (GHRH) and the endocrine response -- Serum arginase in healthy subjects and nitric oxide -- Section 3: Arginine Status in Cells Related to Organ Damage and Disease -- Protein Arginine Methylation of RNA-binding Proteins and Their Impact on Human Diseases -- DNA-arginine adducts and implications in disease -- Homoarginine and L-arginine: Glycine amidinotransferase in stroke -- The L-arginine/asymmetric dimethylarginine (ADMA) ratio in health and disease: an overview -- Arginine and its transporters in colorectal cancer -- Arginine Uptake and Its Role in the Survival of Breast Cancer Cells -- Section 4: Arginine Status and Use in Healthy Individuals -- Arginine production during pregnancy -- L-arginine in the uterus and placenta and during gestation in mammals -- Oral L-arginine supplementation in young males: endocrinology, metabolic, and physiological responses at rest and during exercise -- Metabolic precursors of L-Arginine supplementation in sport: a focus on L-Citrulline and L-Ornithine -- Section 5: Arginine and Diseases of the Gastrointestinal Tract -- Arginine and its use in ameliorating Cryptosporidium parvum infection in undernourished children -- Arginine and Inflammatory Bowel Disease (IBD) -- Dietary L-arginine and intestinal recovery -- Enteral and parenteral arginine supplementation in intestinal ischemia and reperfusion injury -- Mucosal Protection by Arginine in the Upper Gastrointestinal Tract -- Enteral L-arginine and necrotizing enterocolitis -- Section 6: Therapeutic uses of Arginine: Diabetes, Obesity and Cardiovascular Diseases -- L-arginine usage in Type I diabetes: From the autoimmune event to human dietary supplementation -- Oral l-arginine supplementation and glucose metabolism and vascular function -- Arginine enriched apples and diabetic control -- Beneficial impact of cod protein, arginine and other amino acids on insulin sensitivity -- Obese subjects and supplemental L-arginine -- Mitochondrial cardiomyopathy and usage of L-arginine -- Arginine Measurement and Concentrations in Hypertension and other Cardiovascular Disease -- L-Arginine and cardiovascular disease -- Arginine therapy in sickle cell disease -- Section 7: Therapeutic Uses of Arginine: Cancer, Wound Healing and Infectious Disease -- Role of arginine in surgical patients with head and neck cancer -- Arginine-Incorporated Albumin Mesospheres: A Drug Delivery System for Cancer Therapy -- Use of L-arginine and glycine supplementation to reduce radiotherapy damage -- Arginine in Cancer Therapy -- Mechanisms of Arginine-Auxotrophic Response and Their Cancer Therapeutic Implications -- The role of arginine in wound healing -- L-arginine and bacterial translocation: implications for health -- L-arginine in Pulmonary Tuberculosis -- Arginine in Health and Disease: Recommended Resources and Further Reading.
  • Print
    Jahren, Hope.
  • Print
    Joyce LeFever Kee.
    Status: Not Checked Out
  • Digital
    Paul Flecknell.
    ScienceDirect2009
    Preparing for anaesthesia -- Anaesthesia -- Anaesthetic management -- Special techniques -- Analgesia and post-operative care -- Anaesthesia of common laboratory species : special considerations.
  • Digital
    edited by James G. Fox, editor-in-chief, Lynn C. Anderson, Glen M. Otto, Kathleen R. Pritchett-Corning, Mark T. Whary.
    ScienceDirect2015
  • Digital
    edited by Kathryn Bayne, Patricia V. Turner.
    ScienceDirect2014
    Laboratory Animal Welfare provides a comprehensive, up-to-date look into the new science of animal welfare within laboratory research. Animals specifically considered include rodents, cats and dogs, nonhuman primates, agricultural animals, avian animals and aquatic animals. The book examines the impact of experiment design and environment on animal welfare, as well as emergency situations and euthanasia practices. Readers will benefit from a review of regulations and policy guidelines concerning lab animal use, as well as information on assessing animal welfare. With discussions of the history and ethics of animals in research, and a debate on contemporary and international issues, this book is a go-to resource for laboratory animal welfare.
  • Digital
    Javier Guillén.
    ScienceDirect2014
    1. Same principles, some differences / Javier Guillen and Patri Vergara -- 2. Oversight of research animal welfare in the United States / John F. Bradfield, B. Taylor Bennett, and Cynthia S. Gillett -- 3. Canada's oversight of animal use in science / Gilly Griffin and Michael Baar -- 4. Laboratory animal science legislation in Latin America / Ekaterina Akimovna Botovchenco Rivera [and three others] -- 5. The European framework on research animal welfare regulations and guidelines / Javier Guillen [and three others] -- 6. Israeli legislation and regulation on the use of animals in biological and medical research / Rony Kalman [and three others] -- 7. Animal experimentation in Africa : legislation and guidelines / Amanda R. Hau [and five others] -- 8. Laws, regulations, and guidelines shaping research animal care and use in India / Syed SYH Qadri and Christian E. Newcomer -- 9. Oversight of animal research in China / Kathryn Bayne and Jianfei Wang -- 10. Laws, regulations, guidelines, and principles pertaining to laboratory animals in Far East Asia / Tsutomu Miki-Kurosawa, Jae Hak Park, and Chou-Chu Hong -- 11. Laws, regulations, guidelines, and principles pertaining to laboratory animals in Southeast Asia / Montip Gettayacamin [and eight others] -- 12. Laboratory animals regulations and recommendations for global collaborative research : Australia and New Zealand / John Schofield [and three others].
  • Digital
    [edited by] Brigitte Wildemann, Patrick Oschmann, Hansotto Reiber ; with contributions by J. Brettschneider [and others].
    Thieme MedOne Neurosurgery2010
    "Up-to-date, comprehensive, and beautifully illustrated, Laboratory Diagnosis in Neurology presents all the measuring parameters and methods relevant to the analysis of cerebrospinal fluid, serum, and tissues affected by neurologic disease and syndromes. Following an introduction to basic concepts, the book guides clinicians through the methods of CSF analysis, neurochemical examinations, clinical applications of neuroimmunology, microbiology and virology, neurogenetic tests, and evaluation of biopsies. Readers will learn about the equipment and various procedures, and how to effectively differentiate similar methods. In the final section of the book, the authors provide a systematic introduction to the pathophysiology and laboratory findings for specific clinical disorders, indications for particular test methods, and criteria for diagnostic interpretation"--Provided by publisher.
  • Digital/Print
    Witthaus, R. A.
    Digital : Google Books1886-
    Print1886-
  • Digital
    edited by Nenad Blau, Marinus Duran and K. Michael Gibson.
    Springer2008
  • Digital
    Sterling T. Bennett, Christopher M. Lehman, George M. Rodgers, editors ; with contributions by Kristi J. Smock and Robert C. Blaylock.
    Springer2015
  • Print
    editor, George J. Race.
    Status: Not Checked Out
    v. 1. Clinical chemistry -- v. 2. Hematology and blood banking. Medical microbiology, serology, and immunology -- v. 3. Special techniques -- v. 4. Body fluids, including urine. Cytology and cytogenetics. Laboratory management and function -- v. [5] Index.
  • Digital
    [edited by] P. Michael Conn.
    ScienceDirect2012
    Cell biology spans among the widest diversity of methods in the biological sciences. From physical chemistry to microscopy, cells have given up with secrets only when the questions are asked in the right way! This new volume of Methods in Cell Biology covers laboratory methods in cell biology, and includes methods that are among the most important and elucidating in the discipline, such as transfection, cell enrichment and magnetic batch separation. Covers the most important laboratory methods in cell biology Chapters written by experts in their fields.
  • Digital
    [edited by] P. Michael Conn.
    ScienceDirect2013
    Structural dynamics of nucleic acids by single-molecule FRET / Asger Christian Krüger, Lasse Lava Hildebrandt, Sofie Louise Kragh, Victoria Birkedal -- Visualizing the location and the dynamics of gene expression in living animals through bioluminescence imaging / Xiaojuan Chen -- Quality control protocol for confocal system / Anda Cornea -- Electron microscopy of bone / V. Everts, K.A. Hoeben -- Immunostaining : detection of signaling protein location in tissues, cells and subcellular compartments / Biswanath Maity, David Sheff, Rory A. Fisher -- Bimolecular fluorescence complementation (BiFC) analysis of protein-protein interaction : how to calculate signal-to-noise ratio / Yutaka Kodama, Chang-Deng Hu -- Immunohistochemical detection of neuropeptides/transmitters in mammalian brain / Lothar Jennes -- Intravital imaging of autoreactive T. cells in living animals / Naoto Kawakami, Ingo Bartholomäus, Marija Pesic, Nikolaos I. Kyratsous -- Genetically encoded click chemistry for single-molecule FRET of proteins / Swati Tyagi, Edward A. Lemke -- High-throughput methods for the detection of protein overexpression using fluorescence markers / Mads Gabrielsen, Andrew J. Roe, Karen McLuskey -- Correlative microscopy / Alexander A. Mironov, Galina V. Beznoussenko -- Stereology of the lung / Jan Philipp Schneider, Matthias Ochs -- Quantitative 3D cell-based assay performed with cellular spheroids and fluorescence microscopy / Nariman Ansari, Stefanie Müller, Ernst H.K. Stelzer, Francesco Pampaloni -- Optimizing fluorescence excitation and detection for intravital two-photon microscopy / Dan Suan, Henry R. Hampton, Michio Tomura, Osami Kanagawa, Tatyana Chtanova, Tri Giang Phan -- Two-dimensional crystallization by dialysis for structural studies of membrane proteins by the cryo-EM method electron crystallography / Matthew C. Johnson, Ingeborg Schmidt-Krey -- In situ hybridization / Chung-Jui Tsai, Scott A. Harding -- RNA imaging : tracking in real-time RNA transport in neurons using molecular beacons and confocal microscopy / Angélica Zepeda, Clorinda Arias, Fabian Flores-Jasso, Luis Vaca.
  • Digital
    edited by Jon Lorsch.
    ScienceDirect2013
    Section I. Cell protocols : basic microbiological techniques. Pouring agar plates and streaking or spreading to isolate individual colonies / Elizabeth Eyler ; Storage of bacteria and yeast / Cheryl M. Koh -- Section II. Cell protocols : cellular fractionation. Cellular fractionation : mammalian cells / Joerg von Hagen and Uwe Michelsen ; Cellular fractionation : yeast cells / Joerg von Hagen and Uwe Michelsen -- Section III. Cell protocols : Knock-outs and gene replacements. Yeast-gene replacement using PCR products / Megan Bergkessel, Christine Guthrie, and John Abelson ; Measuring RNAi knockdown using qPCR / Stuart Milstein, Michael Nguyen, Rachel Meyers, and Antonin de Fougerolles ; Recombineering : using drug cassettes to knock out genes in vivo / James A. Sawitzke, Lynn C. Thomason, Mikhail Bubunenko, Xintian Li, Nina Costantino, and Donald L. Court ; Gene knockouts, in vivo site-directed mutagenesis and other modifications using the delitto perfetto system in Saccharomyces cerevisiae / Samantha Stuckey and Francesca Storici ; Gene targeting and site-specific recombination in mouse ES cells / Konstantinos Anastassiadis, Frank Schnütgen, Harald von Melchner, and A. Francis Stewart ; Recombineering : highly efficient in vivo genetic engineering using single-strand oligos / James A. Sawitzke, Lynn C. Thomason, Mikhail Bubunenko, Xintian Li, Nina Costantino, and Donald L. Court -- Section IV. Cell protocols : microbiological media. Growth media for E. coli / Juliane C. Lessard ; Saccharomyces cerevisiae growth media / Jessica S. Dymond --Section V. Cell protocols : preparation of slides for microscopy. Immunohistochemistry on freely floating fixed tissue sections / Julia Bachman ; Preparation of slides for microscopy from frozen tissue sections / Julia Bachman ; Preparation of formalin-fixed paraffin-embedded tissue for immunohistochemistry / Kirstie Canene-Adams ; Preparation of cells for microscopy using cytospin / Cheryl M. Koh ; Preparation of cells for microscopy using chamber slides and coverslips / Cheryl M. Koh ; Preparation of cells for microscopy using 'cell blocks' / Cheryl M. Koh -- Section VI. Lipid and carbohydrate protocols. Enzymatic deglycosylation of glycoproteins / Min-Sung Kim and Dan Leahy -- Section VII. Lipid and carbohydrate protocol : making vesicles and micelles. Preparation of fatty acid or phospholipid vesicles by thin-film rehydration / Ting F. Zhu, Itay Budin, and Jack W. Szostak ; Vesicle extrusion through polycarbonate track-etched membranes using a hand-held mini-extruder / Ting F. Zhu, Itay Budin, and Jack W. Szostak ; Preparation of fatty acid micelles / Ting F. Zhu, Itay Budin, and Jack W. Szostak -- Section VIII. Other protocols. Reverse-phase HPLC analysis and purification of small molecules / Kirstie Canene-Adams ; Thin layer chromatography / Marina Santiago and Scott Strobel ; ATP and GTP hydrolysis assays (TLC) / Vaishnavi Rajagopal and Jon R. Lorsch.
  • Digital
    edited by Jon Lorsch.
    ScienceDirect2013
    Explanatory chapter: PCR primer design / Rubén Álvarez-Fernández -- How plasmid preparation kits work / Laura Koontz -- Introducing exogenous DNA into cells / Laura Koontz -- Agarose gel electrophoresis / Laura Koontz -- Analysis of DNA by southern blotting / Gary Glenn and Lefkothea-Vasiliki Andreou -- Purification of DNA oligos by denaturing polyacrylamide gel electrophoresis (PAGE) / Sara Lopez-Gomollon and Francisco Esteban Nicolas -- Molecular cloning / Juliane C. Lessard -- Rapid creation of stable mammalian cell lines for regulated expression of proteins using the Gateway® recombination cloning technology and Flp-In T-REx® lines / Jessica Spitzer, Markus Landthaler, and Thomas Tuschl -- Restrictionless cloning / Mikkel A. Algire -- Isolation of plasmid DNA from bacteria / Lefkothea-Vasiliki Andreou -- Preparation of genomic DNA from bacteria / Lefkothea-Vasiliki Andreou -- Preparation of genomic DNA from Saccharomyces cerevisiae / Jessica S. Dymond -- Isolation of genomic DNA from mammalian cells / Cheryl M. Koh -- Sanger dideoxy sequencing of DNA / Sarah E. Walker and Jon Lorsch -- Preparation of fragment libraries for next-generation sequencing on the applied biosystems SOLiD platform / Srinivasan Yegnasubramanian -- Next generation sequencing / Srinivasan Yegnasubramanian -- Generating mammalian stable cell lines by electroporation / Patti A. Longo, Jennifer M. Kavran, Min-Sung Kim, and Daniel J. Leahy -- Transient mammalian cell transfection with polyethylenimine (PEI) / Patti A. Longo, Jennifer M. Kavran, Min-Sung Kim, and Daniel J. Leahy -- Site-directed mutagenesis / Julia Bachman -- PCR-based random mutagenesis / Jessica S. Dymond -- Megaprimer method for mutagenesis of DNA / Craig W. Vander Kooi -- Troubleshooting PCR / Kirstie Canene-Adams -- Quantitative PCR / Jessica S. Dymond -- General PCR / Kirstie Canene-Adams -- Colony PCR / Megan Bergkessel and Christine Guthrie -- Chemical transformation of yeast / Megan Bergkessel and Christine Guthrie -- Transformation of E. coli via electroporation / Juliane C. Lessard -- Transformation of chemically competent E. coli / Rachel Green and Elizabeth J. Rogers.
  • Digital
    edited by Jon Lorsch.
    ScienceDirectpt. A
    ScienceDirectpt. B
    ScienceDirectpt. C
    ScienceDirectpt. D
  • Digital
    edited by Jon Lorsch.
    ScienceDirect2013
    Computational prediction of RNA secondary structure -- Reverse-transcription PCR (RT-PCR) -- Northern blotting -- Explanatory chapter: nuclease protection assays -- In vitro transcription from plasmid or PCR-amplified DNA -- Measurement of in vivo synthesis rates -- Method for measuring mRNA decay rate in saccharomyces cerevisiae -- Analysis of polysomes from bacteria -- Polysome profile analysis - yeast -- Polysome analysis of mammalian cells -- Polysome analysis for determining mRNA and ribosome association in saccharomyces cerevisiae -- Oligo(dT)-primed RT-PCR isolation of polyadenylated RNA degradation intermediates -- Circularized RT-PCR (cRT-PCR): analysis of the 5' ends, 3' ends, and poly(A) tails of RNA -- RNA radiolabeling -- Fluorescently labeling synthetic RNAs -- Analysis of RNA by analytical polyacrylamide gel -- RNA purification by preparative polyacrylamide gel -- Explanatory chapter: nucleic acid concentration determination -- RNA purification-precipitation methods -- Reverse transcriptase dideoxy sequencing of RNA -- RNA structure experimental analysis-chemical modification -- Structural analysis of RNA backbone using in-line probing.
  • Digital
    edited by Hans J. Hedrich.
    ScienceDirect2012
  • Digital
    Vijai Kumar Gupta, Maria G. Tuohy, editors ; Manimaran Ayyachamy, Kevin M. Turner, Anthonia O'Donovan, associate editors.
    Springer2013
    Laboratory Protocols in Fungal Biology presents the latest techniques in fungal biology. This book analyzes information derived through real experiments, and focuses on cutting edge techniques in the field. The book comprises 57 chapters contributed from internationally recognised scientists and researchers. Experts in the field have provided up-to-date protocols covering a range of frequently used methods in fungal biology. Almost all important methods available in the area of fungal biology viz. taxonomic keys in fungi; histopathological and microscopy techniques; proteomics methods; genomics methods; industrial applications and related techniques; and bioinformatics tools in fungi are covered and complied in one book. Chapters include introductions to their respective topics, list of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting. Each chapter is self-contained and written in a style that enables the reader to progress from elementary concepts to advanced research techniques. Laboratory Protocols in Fungal Biology is a valuable tool for both beginner research workers and experienced professionals.
  • Digital
    edited by Mark A. Suckow, Karla A. Stevens, Ronald P. Wilson.
    ScienceDirect2012
    The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents is a single volume, comprehensive book sanctioned by the American College of Laboratory Animal Medicine (ACLAM), covering the rabbit, guinea pig, hamster, gerbil and other rodents often used in research. This well illustrated reference includes basic biology, anatomy, physiology, behavior, infectious and noninfectious diseases, husbandry and breeding, common experimental methods, and use of the species as a research model. With many expert contributors, this will be an extremely valuable publication for biomedical researchers, laboratory animal veternarians and other professionals engaged in laboratory animal science. A new gold standard publication from the American College of Laboratory Animal Medicine series One stop resource for advancements in the humane and responsible care of: rabbit, guinea pig, hamster, gerbil, chinchilla, deer mouse, kangaroo rat, cotton rat, sand rat, and degu Includes up-to-date, common experimental methods Organized by species for easy access during bench research.
  • Digital
    by Anders Kallner.
    ScienceDirect2014
    Laboratory Statistics: Handbook of Formulas and Terms presents common strategies for comparing and evaluating numerical laboratory data. In particular, the text deals with the type of data and problems that laboratory scientists and students in analytical chemistry, clinical chemistry, epidemiology, and clinical research face on a daily basis. This book takes the mystery out of statistics and provides simple, hands-on instructions in the format of everyday formulas. As far as possible, spreadsheet shortcuts and functions are included, along with many simple worked examples. This book is a must-have guide to applied statistics in the lab that will result in improved experimental design and analysis. Comprehensive coverage of simple statistical concepts familiarizes the reader with formatted statistical expressionSimple, worked examples make formulas easy to use in real lifeSpreadsheet functions demonstrate how to find immediate solutions to common problemsIn-depth indexing and frequent use of synonyms facilitate the quick location of appropriate procedures.
  • Digital
    OHR2003
  • Digital
    edited and authored by Cynthia C. Chernecky, Barbara J. Berger.
    ClinicalKey2013
    "Look no further for quick, complete answers to questions such as which laboratory tests to order or what the results might mean. Laboratory Tests And Diagnostic Procedures, 5th Edition covers more tests than any other reference of its kind, with over 900 lab tests and diagnostic procedures in all. In Part I, you'll find a unique, alphabetical list of hundreds of diseases, conditions, and symptoms, including the tests and procedures most commonly used to confirm or rule out a suspected diagnosis. Part II presents key information on virtually every laboratory and diagnostic test available. All test entries are up-to-date, concise, complete, and consistently presented, making this resource the perfect choice for students or practitioners who need fast, accurate information on diagnostic tests."--Publisher's website.
  • Print
    Sherril L. Green.
    Status: Not Checked Out
    "Even though Xenopus is one of the two most popular non-mammalian animals used in biomedical research, their value in the lab suffers from a lack of standardization regarding their optimal care, breeding, and housing." "Filling the need for such a reference, The Laboratory Xenopus sp. provides researchers and lab managers with a practical, step-by-step manual that emphasizes the humane care and use of captive clawed frogs in basic as well as biomedical, and toxicological research." "Supported with hypothesis-driven research, this well-organized manual explores the full range of responsibilities facing individuals who work with this species. The content is divided into intentionally brief sections that allow for the quick retrieval of essential information regarding important biological features and experimental methodology, as well as compliance and veterinary care, husbandry, housing, and water quality management."--BOOK JACKET.
  • Digital
    Claudia Harper, Christian Lawrence.
    ProQuest Ebook Central2011Limited to 1 simultaneous user
    "Second only to the mouse and rat, Zebrafish are the most popular animal model in biomedical research. Rapid embryonic development and transparent organogenesis, give Zebrafish unique advantages in the study of biological pathways, vertebrate development, carcinogenicity, drug development, genomics, gene function, mutagenesis screening, and toxicology. Providing a quick reference source for basic information and common procedures, this guide is designed for a range of experience levels. It covers all aspects pertaining to the use of these organisms including humane care and management, husbandry, compliance, technical procedures, veterinary care, housing, and water quality management"--Provided by publisher.
  • Digital
    edited by Adam J. Cohen, Michael Mercandetti, Brian Brazzo.
    Springer2015
    While there are books that review lacrimal system disorders and surgery as a section of comprehensive oculoplastic textbooks, The Lacrimal System: Diagnosis, Management and Surgery solely addresses Lacrimology in one concise, practical volume. Building off of the success of the first edition, this text includes significantly updated information, new authors from around the world as well as new chapters that are complete with high quality images and illustrations. Lacrimal surgeries are commonly performed by oculoplastic surgeons and range from alleviating lacrimal system obstructions in children with congenital dysmorphology to minimally invasive lacrimal system reconstruction. The second edition of this book meets the needs of practicing physicians, fellows, and residents who are managing the tearing patient clinically and surgically.
  • Print
    edited by Bruce L. Larson and Vearl R. Smith.
    Status: Not Checked Out
    v. 1. The mammary gland: development and maintenance -- v. 2. Biosynthesis and secretion of milk. Diseases -- v. 3. Nutrition and biochemistry of milk. Maintenance.
  • Digital
    Yoshiharu Takayama.
    Springer2012
    "Lactoferrin was first identified as an iron-binding glycoprotein abundantly found in milk. It has been considered to play important roles in host defense, since lactoferrin shows broad spectrum of anti-bacterial and anti-viral activities, arising from its iron-chelating property. Furthermore, lactoferrin can regulate the function of innate and adaptive immune cells and exhibits immuno-modulating properties. These activities of lactoferrin implicate that potential use of lactoferrin as a wound healing agent. In addition, this book shows that lactoferrin is a potent regulator of dermal fibroblasts and epidermal keratinocytes, and promotes skin or corneal epithelial wound healing by increasing their proliferation, migration or deposition of extracellular matrix (ECM) components such as collagen and hyaluronan. This book provides the scientific background on use of lactoferrin as a wound healing agent. Indeed, lactoferrin exerts its biological effects by binding to specific lactoferrin receptors on target cells. This book also covers the in-depth information on roles of lactoferrin as a signaling molecule."--Publisher's website.
  • Print
    Mary R.S. Creese ; with contributions by Thomas M. Creese.
    "Published in 1998, Ladies in the Laboratory provided a systematic survey and comparison of the work of nineteenth-century American and British women in scientific research. A companion volume, published in 2004, focused on women scientists from western Europe. This third volume, includes the contributions of nineteenth- and early twentieth-century women of South Africa, Australia, New Zealand, and Canada." "The women whose lives and work are discussed here range from natural history collectors and scientific illustrators to the first generation of graduates of new colonial colleges and universities. Rarely acknowledged in the publications of British and European specialists, the contributions of these women nonetheless formed a significant part of the information retrieved and studied about the natural history of extensive, previously unexplored regions." "Rather than a biographical dictionary or a collection of self-contained essays on individuals from many time periods, Ladies in the Laboratory III is a narrative tied into the wider framework of nineteenth-and early twentieth-century science and education. A well-organized blend of individual life stories and quantitative information, this fascinating volume is for anyone interested in the story of women's participation in early science as well as women's and colonial history."--Jacket.
  • Print
    Mary R.S. Creese ; with contributions by Thomas M. Creese.
    Features biographical sketches of over 120 women in botany, chemistry, medicine, paleontology, and zoology.
  • Digital
    Jared Starman.
    Cone-beam computed tomography (CBCT), which uses much of the same hardware as traditional 2-D x-ray fluoroscopy, is now being used during patient treatment. The ability to perform CBCT scans has been driven by the development of amorphous silicon (a-Si) digital flat-panel (FP) x-ray detector technology. These detectors were originally designed for radiography and fluoroscopy, but because of their compactness, flexibility, low spatial distortion, and relative low-cost, are also practical for CBCT. One factor limiting the CBCT image quality for a-Si x-ray detectors is detector lag, stemming from charge trapping in the a-Si layer. Lag is defined as residual signal present in the detector, and can lead to a range of image artifacts in CBCT reconstructions, such as severe image shading for elliptical or off-center objects that could potentially obscure anatomy of interest. Current lag correction methods for a-Si FP detectors assume that the detector is linear and time invariant (LTI) and determine a temporal impulse response for the system. The detector output is deconvolved with the measured impulse response to compute the lag-corrected data. However a conventional FP is neither linear nor time invariant. Different techniques for measuring the FP impulse response are examined, as well as their effect on the final CBCT image reconstruction. A range of results are achieved by the different techniques, highlighting the non-linearity and time variance of the system. A novel non-LTI algorithm is then presented that better describes the x-ray detector dynamics, gives exposure independent results, and provides significant error reduction in CBCT for large objects where lag artifacts are most severe. A second method to reduce lag based on a hardware change to the a-Si detector is also described in this dissertation. The photodiode at each detector pixel is briefly operated in a forward bias mode to maintain saturation of charge trap states. Detector measurements and CBCT scans with and without the detector forward biasing are made to show image improvement and the trade-offs of using the hardware method.
  • Digital
    edited by Graham J. MacKay, Richard G. Molloy, Patrick J. O'Dwyer.
    Oxford Medicine Online2013
    Methodological considerations in surgical trials -- General surgery -- Emergency surgery -- Oesophagogastric surgery -- Hepatopancreaticobiliary surgery -- Colorectal surgery -- Vascular surgery -- Transplant surgery -- Breast surgery -- Endocrine surgery -- Trauma surgery.
  • Print
    edited by Reuben D. Johnson, Alexander L. Green.
    Status: Not Checked Out
    Neurovascular neurosurgery / A.L. Green, R.D. Johnson, R.S.C. Kerr -- Neuro-oncology / R.D. Johnson, K.J. Drummond, K.J.O.L. Khu, M. Bernstein -- Head injury / R.D. Johnson, T. Santarius, J.E. Wilberger -- Spinal surgery / R.D. Johnson, J.C.D. Leach, W.A. Liebenberg, N. Maartens, S.A. Cudlip -- Functional and epilepsy neurosurgery / A.L. Green, R.D. Johnson, A. Astradsson, R.J. Stacey, T.Z. Aziz -- Paediatric neurosurgery / R.D. Johnson, P. Richards, J. Jayamohan, S. Sinha.
  • Digital
    Santosh Yajnik.
    Springer2019
    This book describes the evolution of treatment in oncology through the lens of approximately 250 landmark clinical trials. The well-designed clinical trial is essential to the practice of medicine. There is no field that has embraced or been transformed more by the clinical trial than oncology. Each primary cancer site has a remarkable story that can be told through clinical trials. For example, patients who presented decades ago with soft tissue sarcoma of the extremities would invariably undergo limb amputation. The landmark National Cancer Institute study by Rosenberg et al. randomized patients to limb sparing surgery followed by adjuvant radiation therapy compared with limb amputation. This study helped change the standard of care by allowing most patients to retain their functioning limbs with an improvement in quality of life and no compromise in overall survival. Such major clinical trials for common malignancies including breast, prostate, lung, gastrointestinal, genitourinary, and gynecologic cancers are discussed. Because oncology is multidisciplinary, this book should be of interest for radiation oncologists, surgeons, medical oncologists, and other physicians interested in learning more about the landmark trials that have shaped oncology.
  • Digital
    Shantanu Banik, Rangaraj M. Rangayyan, Graham S. Boag.
  • Digital
    Jacob Michael Rosenberg.
    A fundamental question in immunology is what accounts for the variability observed in susceptibility to infectious diseases. For the last 150 years, galvanized by Pasteur's germ theory of disease, microbiologists and immunologists have made great progress in advancing our understanding of the pathophysiology of infectious microbes. However, animal hosts with apparently identical exposures can have divergent courses of infection. This question can be appreciated by anyone who asks why one sibling falls ill with a common cold while the other does not. In the lay public, these differences are attributed to an individual having a "better immune system, " however in the scientific community we lack a significantly more sophisticated answer to this basic question. In this dissertation, I propose the hypothesis that anti-cytokine autoantibodies (ACAAs) are a factor contributing to the observed variation in susceptibility to infectious diseases. To test this hypothesis, I carried out three specific aims. First, new technologies were needed to address this question. In order to discover novel ACAAs, I developed and validated protein microarray technologies to screen for hundreds of ACAAs in hundreds of patient samples. Second, using protein microarrays and other tools, I performed deep profiling of ACAAs across multiple diseases. I screened blood samples from healthy controls and compared them to those from cohorts of patients with immunodeficiency phenotypes. I performed screens in more than a dozen different primary immunodeficiencies, including diseases with and without known causative genetic mutations and have included some of the most interesting results in this thesis. To summarize results from multiple experiments, a wide diversity of ACAAs are present in healthy individuals and patients with primary immunodeficiencies. In agreement with published findings from other laboratories, in a handful of primary immunodeficiencies, ACAAs against one or a few specific cytokines can be found at high titers and not in healthy controls. I add to this literature with the discovery of high-titer ACAAs against Type I interferon in RAG1/2 mutation-associated immunodeficiency. For some other immunodeficiencies, specific ACAAs can be found at, on average, higher levels than in healthy controls, but these ranges of reactivity still overlap with reactivities found in healthy controls. For example, our discovery of IFN- ACAAs in Immunodysregulation Polyendocrinopathy Enteropathy X-Linked (IPEX) adds to this literature. Third, association with disease does not prove causation. In order to gather evidence for a causal role of ACAAs in contributing to immune deficiency, I purified and tested the function of ACAAs in vitro for blocking activity. I found that some ACAAs, like those against IFN- in IPEX, block in vitro, while others like those found in Wiskott Aldrich Syndrome do not. Taken together, these studies demonstrate that, in health and disease, the human immune system generates a diverse antibody response that reacts against a wide spectrum of antigens, including cytokines. ACAAs, in a few rare diseases, are capable of causing disease with full penetrance. However, our studies provide preliminary evidence that ACAAs may exert partially penetrant phenotypes, including phenotypes potentially based on combinations of ACAAs. Future studies, including immunoglobulin passive transfer studies, will be useful in assessing the contributions of ACAAs to infectious and non-infectious phenotypes.
  • Digital
    Suzanne J. Baron, Chistoph I. Lee.
    AccessMedicine2018Users must register and sign in
  • Digital
    AccessMedicine2005Stanford users must register
    Access to 3000+ exam questions.
  • Print
    T.W. Sadler ; original illustrations by Jill Leland ; computer illustrations by Susan L. Sadler-Redmond ; scanning electron micrographs by Kathy Tosney ; ultrasound images by Nancy Chescheir and Hytham Imseis.
    Status: Not Checked Out
    Embryology : old and new frontiers and an introduction to molecular regulation and signaling -- Gametogenesis : conversion of germ cells into male and female gametes -- First week of development : ovulation to implantation -- Second week of development : bilaminar germ disc -- Third week of development : trilaminar germ disc -- Third to eighth weeks : the embryonic period -- Third month to birth : the fetus and placenta -- Birth defects and prenatal diagnosis -- Skeletal system -- -- Muscular system -- Body cavities -- Cardiovascular system -- Respiratory system -- Digestive system -- Urogenital system -- Head and neck -- Central nervous system -- Ear -- Eye -- Integumentary system.
  • Digital
    T.W. Sadler ; original illustrations by Jill Leland ; computer illustrations by Susan 1. Sadler-Redmond ; scanning electron micrographs by Kathy Tosney ; ultrasound images by Nancy Chescheir and Hytham Imseis.
    LWW Health Library2012
    Reaching far beyond the 9 months of gestation and the first year of life, embryonic development has ramifications for health throughout the human lifespan. Improved reproductive outcomes and healthier babies, while the specific goals of obstetricians, are areas of clinical relevance for all healthcare professionals. This book facilitates understanding of the molecular, cellular, and structural factors contributing to human development. With its trademark approach combining economy of text with exceptional artwork, this revised 12th edition clearly and effectively presents embryology in a clinical context for students of medicine and the health professions. Enhancements to the 12th edition include: An all-new introduction that covers the history and clinical relevance of embryology; Current research and detailed coverage of molecular regulation and signaling, the cardiovascular and digestive system, and the limbs; and each chapter includes overview figures that provide a visual introduction to the material. -- from Back Cover.
  • Digital
    T.W. Sadler, Ph. D., Consultant, Birth Defects Prevention, Twin Bridges, Madison County, Montana, Adjunct Professor of Pediatrics, University of Utah, Visiting Professor of Embroyology, East Tennessee State University, Quillen School of Medicine, Senior Scholar, Greenwood Genetics Center, Greenwood, South Carolina ; computer illustrations by Susan L. Sadler-Redmond ; scanning electron micrographs by Kathy Tosney ; ultrasound images by Jan Byrne and Hytham Imseis.
    LWW Health Library2015
    Offering exceptional full color diagrams and clinical images, Langman's Medical Embryology, 13e helps medical, nursing, and health professions students develop a basic understanding of embryology and its clinical relevance. Concise chapter summaries, captivating clinical correlates boxes, clinical problems, and a clear, concise writing style make the subject matter accessible to students and relevant to instructors. The new edition is enhanced by over 100 new and updated illustrations, additional clinical images and photos of early embryologic development, and an expanded chapter on the cardiovascular system. Clinical Correlates boxes illustrated by cases and images cover birth defects, developmental abnormalities, and other clinical phenomena. More than 400 illustrations?including full-color line drawings, scanning electron micrographs, and clinical images?clarify key aspects of embryonic development. Basic genetic molecular biology principles are highlighted throughout the text to link embryology to other critical specialties. Chapter Overview figures provide a visually compelling introduction to each chapter. Problems to Solve (with detailed answers at the back of the book) help you assess your understanding. An expanded glossary defines key terms and concepts. Online learning resources for students include an interactive question bank and animations.
  • Digital
    T.W. Sadler ; computer illustrations by Susan L. Sadler-Redmond ; scanning electron micrographs by Kathy Tosney ; ultrasound images by Jan Byrne and Hytham Imseis.
    LWW Health Library2019
    "Every student will be affected by pregnancy, either their mother's, because what happens in the womb does not necessarily stay in the womb, or by someone else's. As health care professionals, you will often encounter women of childbearing age who may be pregnant, or you may have children of your own, or maybe it is a friend who is pregnant. In any case, pregnancy and childbirth are relevant to all of us, and unfortunately, these processes often culminate in negative outcomes. For example, 50% of all embryos are spontaneously aborted. Furthermore, prematurity and birth defects are the leading causes of infant mortality and major contributors to disabilities. Fortunately, new strategies can improve pregnancy outcomes, and health care professionals have a major role to play in implementing these initiatives. However, a basic knowledge of embryology is essential to the success of these strategies, and with this knowledge, every health care professional can play a role in providing healthier babies. To accomplish its goal of providing a basic understanding of embryology and its clinical relevance, Langman's Medical Embryology retains its unique approach of combining an economy of text with excellent diagrams and clinical images. It stresses the clinical importance of the subject by providing numerous clinical examples that result from abnormal embryological events. The following pedagogic features and updates in the 14th edition help facilitate student learning"--Provided by publisher.
  • Print
    edited by Michael A. Arbib.
    "This book explores the relationships between language, music, and the brain by pursuing four key themes and the crosstalk among them: song and dance as a bridge between music and language; multiple levels of structure from brain to behavior to culture; the semantics of internal and external worlds and the role of emotion; and the evolution and development of language. The book offers specially commissioned expositions of current research accessible both to experts across disciplines and to non-experts. These chapters provide the background for reports by groups of specialists that chart current controversies and future directions of research on each theme." -- [Publisher-supplied data]
  • Digital
    Valentina Cardella.
    ProQuest Ebook Central2018Limited to 3 simultaneous users
    The enigma of schizophrenia -- Language in schizophrenia -- Schizophrenic language : the cognitive perspective -- Schizophrenic language : the philosophical perspective -- An alternative view : schizophrenia as a disease of language.
  • Digital
    edited by Philip Lanzkowsky, Jeffrey M. Lipton, Jonathan D. Fish.
    ClinicalKey2017
    Diagnostic molecular and genomic methodologies for the hematologist/oncologist -- Hematologic manifestations of systemic illness -- Classification and diagnosis of anemia in children -- Lymphadenopathy and diseases of the spleen -- Anemia during the neonatal period -- Iron-deficiency anemia -- Megaloblastic anemia -- Bone marrow failure -- General considerations of hemolytic diseases, red cell membrane, and enzyme defects -- Extracorpuscular hemolytic anemia -- Hemoglobinopathies -- Polycythemia -- Disorders of white blood cells -- Disorders of platelets -- Disorders of coagulation -- Lymphoproliferative disorders -- Myelodysplastic syndromes and myeloproliferative disorders -- Acute lymphoblastic leukemia -- Acute myeloid leukemia -- Histiocytosis syndromes -- Hodgkin lymphoma -- Non-Hodgkin lymphoma -- Central nervous system malignancies -- Neuroblastoma -- Renal tumors -- Rhabdomyosarcoma and other soft-tissue sarcomas -- Malignant bone tumors -- Retinoblastoma -- Germ cell tumors -- Hepatic tumors -- Hematopoietic stem cell transplantation -- Management of oncologic emergencies -- Supportive care of patients with cancer -- Evaluation, investigations, and management of late effects of childhood cancer -- Psychosocial aspects of cancer for children and their families -- Blood banking principles and practices -- Hematological reference values -- Biological tumor markers.
  • Digital
    Reinhard Bittner [and 5 others].
    Springer2018
  • Digital
    Jens-Uwe Stolzenburg, Ingolf A. Türk, Evangelos N. Liatsikos (editors).
    Springer2011
    Upper Urinary Tract (Kidney, Ureter and Adrenal Gland) / Jens-Uwe Stolzenburg, Rowan Casey, Jens Mondry, Minh Do and Anja Dietel, et al. -- Lympadenectomy / Ingolf A. Türk, Rowan Casey, Jens-Uwe Stolzenburg, Panagiotis Kallidonis and Minh Do, et al. -- Urinary Bladder and Prostate / Thilo Schwalenberg, Jochen Neuhaus, Panagiotis Kallidonis, Evangelos N. Liatsikos and Jens-Uwe Stolzenburg, et al. -- Paediatric Urology / Holger Till, Jens-Uwe Stolzenburg and Ulrike Waldschmidt -- Miscellaneous / Jens-Uwe Stolzenburg, Evangelos N. Liatsikos, Thilo Schwalenberg, Tim Häfner and Minh Do, et al.
  • Digital
    Karl A. LeBlanc, editor.
    Springer2018
    This book provides comprehensive advice and recommendations to surgeons practicing the laparoscopic repair of incisional hernias. It opens with a brief history and evolution of the technology surrounding the repair of incisional and ventral hernias laparoscopically and includes the introduction of robotic technology, which is constantly undergoing further refinement as new devices are introduced. The text discusses areas of controversy, as well as the limits and benefits of using this technology in the laparoscopic approach. Written by the current thought leaders of minimally invasive techniques, this helpful resource provides current opinions and methods in incisional and ventral hernia repair. Laparoscopic And Robotic Incisional Hernia Repair: Current Considerations provides a valuable resource for both seasoned laparoscopic surgeons interested in the technical aspects of incisional and ventral hernia repair.
  • Digital
    Ferdinando Agresta, Fabio Cesare Campanile, Nereo Vettoretto, editors.
    Springer2014
    "his book, written by expert surgeons, offers a comprehensive and up-to-date overview of all aspects of laparoscopic cholecystectomy. Coverage includes the indications for surgery, anesthesia, establishment of pneumoperitoneum, surgical technique, and the prevention and management of complications. Performance of laparoscopic cholecystectomy in the specific contexts of biliary tree stones and acute cholecystitis is described. Extensive reference is made to the latest clinical evidence, and the real benefits of the laparoscopic approach, for example in terms of outcomes and day surgery, are carefully assessed. New technologies, including SILS, NOTES, robotic surgery, and miniaturized instruments, are reviewed. The learning curve and training are also extensively discussed, and an individual chapter is devoted to the views of international experts in the field. Some 20 years after the National Institutes of Health Consensus Conference first published recommendations regarding indications for laparoscopic cholecystectomy, it remains the gold standard approach and continues to evolve."--Publisher's website.
  • Digital
    Makio Mike.
    Springer2017
    This unique guide describes colorectal surgery procedures using medical terminology and anatomical terms originating from embryology. In the last decade, laparoscopic procedures in gastrointestinal surgery have been enhanced and their safety has significantly improved. With the number of cases of colorectal cancer surgery increasing and laparoscopic surgery no longer considered a specialized surgery, the recognition of the correct anatomy is vital in these procedures. Unfortunately, however, the understanding of clinical anatomy is frequently separate from that of basic surgical concepts. Initially, the dissecting layer should be presumed to derive from the fascial anatomy based on embryological recognition. Furthermore, the techniques currently being used by surgeons should be described in sufficient detail and the appropriate anatomical terms should always be used. In view of this, this valuable monograph benefits gastrointestinal surgeons and general surgeons who are involved in the treatment of colorectal cancer.
  • Digital
    Mahesh R. Desai, Arvind P. Ganpule, editors.
    Springer2017
  • Digital
    Andrea Tinelli, editor.
    Springer2012
    Anatomy of the abdominal wall and vaginal entry in relation to complications of access and injury in laparoscopy / Tom A.J. Schneider -- Surgical technique of traditional laparoscopic access / Gernot Hudelist and Jorg Keckstein -- Laparoscopic abdominal entry by the ternamian threaded visual system / Artin Ternamian -- Initial access to the peritoneal cavity for laparoscopic surgery in obese patients / Charlotte Rabl and Guilherme M. Campos -- The direct optical access: a feasible, reliable, and safe laparoscopic entry / Andrea Tinelli -- Robotic assisted surgery and related abdominal entry / Crisitina Falavolti, Roberto Angioli, Patrizio Damiani, and Maurizio Buscarini -- Robotic assisted surgery entry into gynecological oncology / Farr R. Nezhat and Shao-Chun R. Chang-Jackson -- Single access surgery: less is more? / Tahar Benhidjeb, Michael Stark, Jakob R. Izbicki, and Oliver Mann -- Reduced port surgery: single port access to the abdominal and pelvic cavity / Paul G. Curcillo II, Stephanie A. King, and Erica R. Podolsky -- The evolution of minimally invasive gynecological surgery: gas-less laparoscopic inspection and single hole surgery (GLISHS) / Nicola Gasbarro, Maurizio Brusati, Pietro Lupo, Sandro Gerli, and Gian Carlo Di Renzo -- First abdominal access in gynecological laparoscopy: comparison of techniques / Antonio Malvasi and Andrea Tinelli -- Blind entry at gynecological laparoscopy is substituted by entry under sight: complications in conventional laparoscopic entry / Liselotte Mettler, Wael Sammur, and Antonio Malvasi -- Natural orifice surgery: surgical procedures through natural body openings / Michael Stark and Tahar Benhidjeb -- Access in natural orifice transvaginal endoscopic surgery / Daniel A. Tsin.
  • Digital
    Chang-Ming Huang, Chao-Hui Zheng, editors.
    Springer2015
  • Digital
    author, Karl Miller ; assisted by Birgit Wahl ... [et al.].
    Springer2011
  • Digital
    Xiujun Cai.
    Springer2015
    Anatomy of the Liver in the Laparoscopic Situation -- Instruments for Laparoscopic Hepatectomy by Curettage and Aspiration -- Laparoscopic Left Lateral Segmentectomy -- Laparoscopic Left Hemihepatectomy -- Laparoscopic Right Hemihepatectomy -- Laparoscopic Resection of Caudate Lobe -- Laparoscopic Non-Anatomical Liver Resection -- Two-Stage Completely Laparoscopic Hemihepatectomy -- Laparoscopic Radical Resection of Gallbladder Cancer -- Other Techniques for Laparoscopic Hepatectomy.
  • Digital
    edited by Claudius Conrad, Brice Gayet.
    Wiley2017
  • Digital
    Rong Liu.
    Springer2017
    Laparoscopic Anatomical Hepatectomy -- Positioning and Accesses -- Preoperative Preparation and Anesthesia -- Laparoscopic Fenestration of Liver Cyst -- Laparoscopic Partial Hepatectomy -- Laparoscopic Single-site Hepatectomy -- Laparoscopic Left Lateral Sectionectomy -- Laparoscopic Left Hepatectomy -- Laparoscopic Right Posterior Sectoretomy -- Retroperitoneal Laparoscopic Hepatectomy -- Laparoscopic Right Hepatectomy -- Laparoscopic Caudate Lobectomy -- Radiofrequency Ablation Assisted Laparoscopic Hepatectomy -- Robotic Assisted Laparoscopic Hepatectomy.
  • Digital
    Peter von Theobald.
    Springer2017
    This book offers a practical surgical guide, helping surgeons learn the technique needed to perform Laparoscopic SacroColpoPexy (LSCP). To do so, it explains the surgical process in straightforward language, supplemented by images and diagrams, while also discussing why this procedure is so effective. The book has two primary goals: to provide those surgeons who have never performed LSCP before with essential insights and technical expertise, based on the author's 20 years of practical surgical experience; and to allay the common fear of possible complications. Following a 2012 FDA warning, surgeons whose work involved vaginal prolapse repair have been looking for an alternative technique. Though LSCP offers a safe alternative to current methods, the available literature on it is sparse. This book provides a comprehensive guide to the techniques and methods needed by surgeons operating on pelvic organ prolapse in a range of different specialties, including urogynecology, urology, and gynecology.
  • Digital
    Giusto Pignata, Umberto Bracale, Fabrizio Lazzara, editors.
    Springer2016
    Esophagus and Stomach -- Liver, Gallbladder, and Biliary Tree -- Abdominal Wall -- Colon, Rectum, and Appendix -- Kidney, Adrenal Gland, Ureter, and Varicocele -- Spleen and Pancreas -- Bariatic Surgery -- Gynecology.
  • Digital
    by Bertrand Guillonneau, Inderbir S. Gill, Günter Janetschek, Ingolf A. Tuerk.
    Springer2009
  • Digital
    Felix Schier, Salmai Turial.
    Springer2013
    When Laparoscopy in Children was first published in 2003, it quickly became popular with pediatric surgeons worldwide owing to its clear schematic drawings and concise text. This new edition has been revised and enlarged to cover the new procedures and other advances that have emerged in the intervening period, during which the number of operations has almost doubled. Now, the vast majority of indications for laparoscopy in children are presented and discussed. Each operation is systematically described and illustrated step by step, providing the reader with the technical guidelines required to perform laparoscopy safely even in small children. Laparoscopy in Children will be an invaluable guide for all surgeons who perform, or plan to perform, such operations.
  • Digital
    editor, Michael Laposata, MD, PhD, [edition] editors, Michael Weitz and Peter J. Boyle.
    AccessMedicine2019
    "The acclaimed full-color guide to selecting the correct laboratory test and interpreting the results covering ALL of clinical pathology Laboratory Medicine is the most comprehensive, user-friendly, and well-illustrated guide available for learning how to order the correct laboratory test and understand the clinical significance of the results. The book features an easy-to-follow, consistent presentation for each disease discussed. Chapters begin with a brief description of the disorder followed by a discussion that includes tables detailing the laboratory evaluation of specific disorders, diagnosis, baseline tests to exclude diagnostic possibilities, and clinical indications that warrant further screening and special testing. With new, increasingly expensive and complicated tests appearing almost daily, Laboratory Medicine, Third Edition is required reading for medical students, clinical laboratory scientists, and healthcare professionals who want to keep abreast of the latest testing procedures and maximize accuracy and patient safety. Features: 48 clinical laboratory methods presented in easy-to-understand illustrations that include information on the expense and complexity of the assays More than 200 tables and full-color algorithms that encapsulate important information and facilitate understanding Full-color blood-smear micrographs that demonstrate common abnormal morphologies of red blood cells Valuable learning aids in each chapter, including learning objectives, chapter outlines, and a general introduction -- and new to this edition: chapter-ending self-assessment Q&A. Logical systems-based organization that complements most textbooks Extensive table of Clinical Laboratory Reference Values that show the conversions between U.S. and SI units for -- Provided by publisher.
  • Digital
    Mark Wagner.
    The cerebellum is critical for learning skilled movements such as reaching and manipulating objects. Coordination of ensemble neuronal spiking may be key to cerebellar control of movement, but is largely unexplored during skilled behavior. Here we show that skilled reaching tasks evoke novel coordinated silence, spiking, and motor coding seen only by monitoring many Purkinje neurons simultaneously. We designed a robotic manipulandum that mice grasped while making targeted reaches during 2-photon calcium imaging. Neurons often all stopped spiking together, much more frequently than observing each neuron separately would predict. This concerted silence signaled individual reaches more effectively than ensemble average spiking. We also found that collective synchronous spiking near reach onset accompanied less jerky and variable movements. Robotic perturbations to reaching elicited collective direction-selective synchrony. These coordinated activity patterns were unavailable from individual neurons or traditional population averages and hint at a novel reaching-evoked coordinated cerebellar circuit state.
  • Digital
    edited by Bernd Blobel, Rolf Engelbrecht, and Michael A. Shifrin.
    eBook Comp Acad2012
  • Digital
    Yann Chong Tan.
    Despite tremendous progress in understanding immune responses, the ability to characterize functional antibody responses remains limited. I developed a method that utilizes barcoding to enable high-throughput sequencing of paired heavy-chain and light-chain immunoglobulin sequences. This approach enables us to generate dendrograms of functional affinity-matured antibody responses, and express selected antibodies for functional characterization. This method was applied to a human who received an influenza vaccine, humans with Staphylocuccus aureus infection, a human with rhuematoid arthritis, an autoimmune disease, and a human who has lung adenocarcinoma, and is a long term non-progressor. These are examples in vaccination, infection, autoimmune disease and cancer, respectively. In each case, we show that we were able to obtain paired heavy and light chain sequences. We expressed selected antibodies for functional characterization and showed that we were able to obtain functional antibodies that bound to target antigens in each of the above indications. Furthermore, we also showed that large clonal families dominate in influenza vaccination, and that larger antibody clonal families have higher binding affinities. Taken together, the approach provides a method to directly characterize functional antibody responses that could advance our understanding of protective and pathogenic immune responses in health and disease.
  • Digital
    Zvi Laron, John J. Kopchick, editors.
    Springer2011
    Laron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Since then, many patients worldwide have been diagnosed with LS, which involves defects in the GH receptor that cause combined congenital deficiency of GH and IGF-I activities. In this comprehensive book the authors draw upon 50 years of multidisciplinary clinical and investigative follow-up of the large Israeli cohort of LS patients. The genetic basis of the syndrome is fully considered, and all aspects of the pathophysiology of IGF-I deficiency are described. Data derived from the recently generated mouse model of LS are reviewed and compared with the human LS experience. Valuable advice is provided on treatment, and treatment effects, such as metabolic effects, adipose tissue alterations, and impact on aging, are fully explored. Together, this book condenses, consolidates, compares, and contrasts data derived from the human and mouse LS experiences and provides a unique resource for clinical and basic scientists to evaluate and compare IGF-I and GH actions.
  • Print
    Gary C. Schoenwolf, Steven B. Bleyl, Philip R. Brauer, Philippa H. Francis-West.
    Status: Not Checked Out
    Gametogenesis, fertilization, and first week -- Second week: becoming bilaminar and fully implanting -- Third week: becoming trilaminar and establishing body axes -- Fourth week: forming the embryo -- Principles and mechanisms of morphogenesis and dysmorphogenesis -- Fetal development and the fetus as patient -- Development of the skin and its derivatives -- Development of the musculoskeletal system -- Development of the central nervous system -- Development of the peripheral nervous system -- Development of the respiratory system and body cavities -- Development of the heart -- Development of the vasculature -- Development of the gastrointestinal tract -- Development of the urogenital system -- Development of the pharyngeal apparatus and face -- Development of the ears and eyes -- Development of the limbs.
  • Digital
    Gary C. Schoenwolf, Steven B. Bleyl, Philip R. Brauer, Philippa H. Francis-West.
    ClinicalKey2015
    Gametogenesis, fertilization, and first week -- Second week : becoming bilaminar and fully implanting -- Third week : becoming trilaminar and establishing body axes -- Fourth week : forming the embryo -- Principles and mechanisms of morphogenesis and dysmorphogenesis -- Fetal development and the fetus as patient -- Development of the skin and Its derivatives -- Development of the musculoskeletal system -- Development of the central nervous system -- Development of the respiratory system and body cavities -- Development of the heart -- Development of the vasculature -- Development of the gastrointestinal tract -- Development of the urinary system -- Development of the pharyngeal apparatus and face -- Development of the ears -- Development of the eyes -- Development of the limbs.
  • Digital
    Nausheen Jamal, Marilene B. Wang, editors.
    Springer2019
    This comprehensive text provides the reader with an in-depth understanding of laryngopharyngeal reflux (LPR), and presents a practical and readable evidence-based approach to the diagnosis and management of patients with this condition. It highlights options for management of those patients who fail to improve with traditional reflux treatment and assists in determining the next steps in the management of this population. Information is presented from an inter-disciplinary perspective, including input by otolaryngology, gastroenterology, speech pathology, and complementary/integrative medicine. The first section of the book is dedicated to understanding the fundamentals of laryngopharyngeal reflux as a condition. It begins with a review of the fundamental anatomy and pathophysiology of LPR and summarizes the landmark and most recent advances in the scientific understanding of this condition. Subsequent chapters delve into the typical symptoms and clinical presentations of patients, with information provided on cost-effective work-up strategies to confirm the diagnosis. The second section focuses on management of this condition. It begins with a thorough review of traditional medical management, including use of proton pump inhibitors, histamine receptor antagonists, neutralizing agents, low acid diet, alkalinizing agents, and alginates. Surgical management is reviewed as well, including partial and full fundoplication operations. It concludes with "non-traditional" treatment options for LPR, with chapters dedicated to voice therapy, probiotics, herbal therapies, and integrative East-West medicine approaches. Laryngopharyngeal Reflux Disease will be a definitive guide for otolaryngologists, gastroenterologists, speech pathologists, and general physicians with an interest in traditional and complementary/integrative treatments for patients with laryngopharyngeal reflux.
  • Digital
    Christian Raulin, Syrus Karsai (editors).
    Springer2011
    Part 1 Basics -- Basic Laser Physics -- Laser-Tissue Interactions -- Intense Pulsed Light Technology -- Part 2 Indications -- Benign Tumors and Organoid Nevi -- Facial Rejuvenation and Other Clinical Applications of Intense Pulsed Light -- Inflammatory Dermatoses: Acne -- Inflammatory Dermatoses: Other than Acne Vulgaris -- Laser-Assisted Liposuction -- Photoepilation of Unwanted Hair Growth -- Pigmentation and Hypopigmentation: Benign Pigmented Lesions -- Pigmentation and Hypopigmentation: Vitiligo and Other Disorders -- Precancerous Conditions and Malignant Tumors -- Scars, Keloids, and Stretch Marks -- Laser Treatment of Tattoos and Other Dyschromia -- Varicose Veins: Endovenous Laser Treatment -- Common Vascular Lesions -- Vascular Lesions: Port Wine Stains -- Vascular Lesions: Hemangiomas -- Rare Vascular Lesions -- Viral Infections -- Wrinkles and Acne Scars: Ablative and Nonablative Facial Resurfacing -- Wrinkles and Acne Scars: Technology-Based Treatment of Periorbital Wrinkles -- Wrinkles and Acne Scars: Fractional Ablative Lasers -- Wrinkles and Acne Scars: Fractional Nonablative Lasers -- Part 3 Special Aspects -- Complications in Laser Surgery and IPL Treatment -- Cooling Techniques -- Ethical Considerations in Aesthetic Medicine -- Photodynamic Therapy -- Quality Standards in Aesthetic Medicine -- Safety/Eye Protection -- Part 4 Afterword -- The Business of Laser Surgery How Our Lives are Challenged by Healthcare Regulations, the FDA, and Quackery -- The Hall of Shame.
  • Digital
    edited by Graeme I. Murray.
    Springer2011
    Laser capture microdissection : methods and applications / Kristen DeCarlo . [and others] -- Laser microdissection for gene expression profiling / Lori A. Field [and others] -- Gene expression using the PALM system / Jian-Xin Lu and Cheuk-Chun Szeto -- Immunoguided microdissection techniques / Michael A. Tangrea [and others] -- Optimized RNA extraction from non-deparaffinized laser-microdissected material / Danny Jonigk [and others] -- Laser capture microdissection for analysis of gene expression in formalin-fixed paraffin-embedded Tissue / Ru Jiang, Rona S. Scott, and Lindsey M. Hutt-Fletcher -- MicroRNA profiling using RNA from microdissected immunostained tissue / Clemens L. Bockmeyer [and others] -- Profiling solid tumor heterogeneity by LCM and biological MS of fresh-frozen tissue sections / Donald J. Johann [and others] -- Amplification testing in breast cancer by multiplex ligation-dependent probe amplification of microdissected tissue / Cathy B. Moelans, Roel A. de Weger, and Paul J. van Diest -- Detection and quantification of MicroRNAs in laser-microdissected formalin-fixed paraffin-embedded breast cancer tissues / Sarkawt M. Khoshnaw [and others] -- Laser capture microdissection applications in breast cancer proteomics / Rene B.H. Braakman [and others] -- Proteomic analysis of laser microdissected ovarian cancer tissue with SELDI-TOF MS / Isabelle Cadron [and others] -- LCM Assisted biomarker discovery from archival neoplastic gastrointestinal tissues / Patricia A. Meitner and Murray B. Resnick -- Purification of diseased cells from Barrett's esophagus and related lesions by laser capture microdissection / Masood A. Shammas and Manjula Y. Rao -- Laser microdissection of intestinal epithelial cells and downstream analysis / Benjamin Funke -- Application of laser microdissection and quantitative PCR to assess the response of esophageal cancer to neoadjuvant chemo-radiotherapy / Claus Hann von Weyhern and Bjorn L.D.M. Brucher -- Oligonucleotide microarray expression profiling of contrasting invasive phenotypes in colorectal cancer / Christopher C. Thorn, Deborah Williams, and Thomas C. Freeman -- Evaluation of gastrointestinal mtDNA depletion in mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) / Carla Giordano and Giulia d'Amati -- Laser microdissection for gene expression study of hepatocellular carcinomas arising in cirrhotic and non-cirrhotic livers / Maria Tretiakova and John Hart -- Laser capture microdissection of pancreatic ductal adeno-carcinoma cells to analyze EzH2 by western blot analysis / Aamer M. Qazi [and others] -- Laser-capture microdissection of renal tubule cells and linear amplification of RNA for microarray profiling and real-time PCR / Susie-Jane Noppert, Susanne Eder, and Michael Rudnicki -- Subcellular renal proximal tubular mitochondrial toxicity with tenofovir treatment / James J. Kohler and Seyed H. Hosseini -- Application of laser-capture microdissection to study renal carcinogenesis / Kerstin Stemmer and Daniel R. Dietrich -- Laser-capture microdissection and transcriptional profiling in archival FFPE tissue in prostate cancer / Ajay Joseph and Vincent J. Gnanapragasam -- Quantitative analysis of the enzymes associated with 5-Fluorouracil metabolism in prostate cancer biopsies / Tomoaki Tanaka -- Microdissection of gonadal tissues for gene expression analyses / Anne Jørgensen, Marlene Danner Dalgaard, and Si Brask Sonne -- Duplex real-time PCR assay for quantifying mitochondrial DNA deletions in laser microdissected single spiral ganglion cells / Adam Markaryan, Erik G. Nelson, and Raul Hinojosa -- Neuronal type-specific gene expression profiling and laser-capture microdissection / Charmaine Y. Pietersen . [et al.] -- Region-specific in situ hybridization-guided laser-capture microdissection on postmortem human brain tissue coupled with gene expression quantification / Rene Bernard, Sharon Burke, and Ilan A. Kerman -- UV-laser microdissection and mRNA expression analysis of individual neurons from postmortem Parkinson's disease brains / Jan Grundemann, Falk Schlaudraff, and Birgit Liss -- Transcriptome profiling of murine spinal neurulation using laser capture microdissection and high-density oligonucleotide microarrays / Shoufeng Cao, Boon-Huat Bay, and George W. Yip -- Probing the CNS microvascular endothelium by immune-guided laser-capture microdissection coupled to quantitative RT-PCR / Nivetha Murugesan [and others] -- Laser-capture microdissection for factor VIII-expressing endothelial cells in cancer tissues / Tomoatsu Kaneko [and others] -- Laser-capture microdissection and analysis of liver endothelial cells from patients with Budd-Chiari syndrome / Selcuk Sozer and Ronald Hoffman -- Laser-capture microdissection of hyperlipidemic/ApoE-/- mouse aorta atherosclerosis / Michael Beer [and others] -- Gene expression profiling in laser-microdissected bone marrow megakaryocytes / Kais Hussein -- Specific RNA collection from the rat endolymphatic sac by laser-capture microdissection (LCM) : LCM of a very small organ surrounded by bony tissues / Kosuke Akiyama [and others] -- Use of laser capture microdissection on adult human articular cartilage for gene expression analysis / Naoshi Fukui, Yasuko Ikeda, and Nobuho Tanaka -- Laser-capture microdissection of developing barley seeds and cDNA array analysis of selected tissues / Johannes Thiel, Diana Weier, and Winfriede Weschke -- Quantitative RT-PCR gene expression analysis of a laser microdissected placenta : an approach to study preeclampsia / Yuditiya Purwosunu [and others].
  • Digital
    edited by Graeme I. Murray.
    Springer2018
    This fully updated edition provides practical advice on how to carry out tissue-based laser microdissection successfully by using the different laser microdissection systems that are available and by applying a wide range of molecular technologies. The contents of the volume explore these techniques that have revolutionized carrying out molecular analysis on specific types of normal and diseased cells and fully utilizing the power of current molecular technologies including PCR, microarrays, next generation sequencing, and proteomics. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, this book seeks to aid researchers generally and pathologists in particular in moving their studies forward with these techniques.
  • Digital/Print
    edited by P. Michael Conn.
    Digital : ScienceDirect2002
    Print2002
  • Digital
    David J. Goldberg, editor.
    Springer2013
    This is the second edition of a well-received book that has been revised and updated to reflect the state of the art in laser and light source technology. After an initial chapter describing the latest understanding of laser physics and safety, subsequent chapters consider laser treatment of vascular lesions, laser treatment of pigmented lesions and tattoos, laser removal of unwanted hair, ablative and non-ablative fractional resurfacing, and use of laser treatment for medical purposes. The book is extremely practical and reader friendly. All chapters are very well illustrated, include quick and clear bullet points, and feature a homogeneous structure covering core concepts, currently available technologies, indications and contraindications, an example of a consent form, and the author's personal treatment approaches. The authors are without exception world experts in the field from North America or Europe.
  • Digital
    edited by Alberto Piqué and Pere Serra.
    Wiley2018
    1. Introduction to laser-induced transfer and other associated processes -- 2. Origins of laser-induced transfer processes -- 3. LIFT using a dynamic release layer -- 4. Laser-induced forward transfer of fluids -- 5. Advances in blister-actuated laser-induced forward transfer (BA-LIFT) -- 6. Film-free LIFT (FF-LIFT) -- 7. Laser-induced forward transfer of metals -- 8. LIFT of solid films (ceramics and polymers) -- 9. Laser-induced transfer of soft materials -- 10. Congruent LIFT with high-viscosity nanopastes -- 11. Laser printing of nanoparticles -- 12. Laser printing of electronic materials -- 13. Laser printing of chemical and biological sensors -- 14. Laser printing of proteins and biomaterials -- 15. Laser-assisted bioprinting of cells for tissue engineering -- 16. Industrial, large-area, and high-throughput LIFT/LIBT digital printing -- 17. LIFT of 3D metal structures -- 18. Laser transfer of entire structures and functional devices.
  • Digital
    edited by Lidia Bakota, Department of Neurobiology, University of Osnabrück, Osnabrück, Germany, Roland Brandt, Department of Neurobiology, University of Osnabrück, Osnabrück, Germany.
    Springer2014
  • Digital
    edited by Ronald J. Riegel, John C. Godbold, Jr.
    Wiley2017
    Part I: The History of Laser Therapy -- Part II: The Theory and Science of Laser Therapy -- Part III: Practical Applications of Laser Therapy -- Part IV: Clinical Applications of Laser Therapy in Companion Animals -- Part V: Clinical Applications of Laser Therapy in Canine Sports Medicine -- Part VI: Clinical Applications of Laser Therapy in Companion Animal Rehabilitation -- Part VII: Clinical Applications of Laser Therapy in Exotic Animals -- Part VIII: Clinical Applications of Laser Therapy in Equine Practice -- Part IX: Clinical Applications of Laser Therapy in Food Animal Practice -- Part X: Laser Therapy and Alternative and Regenerative Therapies -- Part XI: Integrating Laser Therapy into Veterinary Medicine.
  • Digital
    Christopher Koerner Sramek.
    Since its introduction nearly 40 years ago, laser photocoagulation has been the standard of care for treatment of numerous retinal pathologies. Recently, new approaches have been introduced for more selective targeting of various retinal layers, including patterned scanning photocoagulation, selective retinal therapy, and sub-lethal treatment. Despite its broad use in clinical practice, there remains a need for the quantitative description of laser-tissue interactions involved in retinal phototherapy. A unified description of various treatment regimes and associated mechanisms of tissue damage would allow for optimization of laser parameters to improve selectivity and safety of retinal photocoagulation, and for avoidance of undesirable collateral damage. The presented work describes an investigation into the dynamics of the retinal response to hyperthermia and vaporization. A finite-element computational model of photocoagulation and rupture was constructed based on experimental measurements of laser interactions with tissue, and verified in vivo in the millisecond time domain. Two approaches towards improvement of tissue heating uniformity were studied: spatial and temporal modulation of the treatment beam. After optimization using the computational model, beam shaping and pulse modulation systems were constructed. Experimental studies in vivo confirmed improvements in safety of the retinal treatment, potentially allowing for reductions in treatment time, thermal damage extent, and perceived pain. In addition, tissue response to sub-lethal thermal stress in the retina was explored using expression of heat shock protein in an animal model. Computational modeling of the corresponding treatment regime demonstrated that a similar response is likely to occur in clinical application of sub-lethal exposures. Photo-mechanical interactions in the retina were investigated in model systems and in vivo with microsecond-range exposures. The dominant mechanisms of tissue damage were identified and the corresponding limits of the safe therapeutic window were computed over a broad range of pulse durations - from microseconds to seconds. An understanding of the thermal and mechanical interactions involved in laser heating of the retina allows for the realization of safer and more selective treatment regimes. All three mechanisms investigated in the current study -- photocoagulation, photomechanical interactions and sub-lethal hyperthermia -- play a role in clinical treatment. The developed quantitative models of these interactions have immediate applicability to clinical practice, providing guidance towards optimization of retinal phototherapy, evaluation of retinal safety, and development of new clinical applications.
  • Digital
    volume editors, Susan Bard, New York, N.Y., David J. Goldberg, New York, N.Y.
    Karger2014
    Today, nearly 60 years after the invention of the first medical laser, multiple laser and light systems exist and are applied in various medical specialties such as dermatology, ophthalmology, and urology. This volume - the first in the series Aesthetic Dermatology - focuses on the laser treatment of cutaneous lesions with a vascular target. Each chapter describes a particular laser or light modality and its specific application to a variety of both vascular and nonvascular lesions. Renowned specialists in laser medicine have contributed their expertise, incorporating current evidence-based literature and their own personal treatment recommendations, as well as pearls and perils. The purpose of this book is to explore the options and parameters available to treat cutaneous lesions traditionally responsive to vascular laser therapy and to expand the application to further lesion treatments. Readers who wish to broaden their knowledge and further hone their skills in treating cutaneous vascular lesions with lasers will find this publication a valuable and comprehensive review.
  • Digital
    Maria Claudia Almeida Issa, Bhertha Tamura, editors.
    Springer2018
    The series “Clinical Approach and Procedures in Cosmetic Dermatology” intends to be a practical guide in Cosmetic Dermatology. Procedures in cosmetic dermatology are very popular and useful in medicine, indicated to complement topical and oral treatments not only for photodamaged skin but also for other dermatosis such as acne, rosacea, scars, etc. Also, full-face treatments using peelings, lasers, fillers and toxins are increasingly being used, successfully substituting or postponing the need for plastic surgeries. Altogether, these techniques not only provide immediate results but also help patients to sustain long-term benefits, both preventing/treating dermatological diseases and maintaining a healthy and youthful skin. Throughout this series, different treatments in Cosmetic Dermatology will be discussed in detail covering the use of many pharmacological groups of cosmeceuticals, the new advances in nutraceuticals and emerging technologies and procedures. This volume addresses the most important physical approaches in cosmetic dermatology, disclosing their uses and advantages. Here are discussed in detail the applicability of lasers and other lights, photodynamic therapy, radiofrequency, ultrasound and transepidermal drug delivery.
  • Digital
    [edited by] William H. Truswell.
    Thieme-Connect2016
  • Digital
    edited by George J. Hruza, Elizabeth L. Tanzi ; series editor, Jeffrey S. Dover ; associate editor, Murad Alam.
    ClinicalKey2018
    "Part of the practical and dynamic Procedures in Cosmetic Dermatology Series, Lasers and Lights, 4th Edition, brings you up to speed with today's best methods for using laser light to treat skin disorders. This well-organized text by Drs. George J. Hruza and Elizabeth L. Tanzi provides current, authoritative guidance on popular procedures including laser hair removal, tattoo removal, acne scars, vascular lesions, non-ablative fractional laser rejuvenation, ablative laser resurfacing, and tissue tightening. Drs. George Hruza and Elizabeth Tanzi offer evidence-based, procedural how-to's and step-by-step advice on proper techniques, pitfalls, and tricks of the trade, so you can successfully incorporate the latest procedures into your practice"--Publisher's description.
  • Digital
    O. Topaz, editor.
    Springer2015
    Preface -- Laser physics and laser sources for cardiovascular applications -- Optic fibers and mechanical properties of laser catheters -- Landmarks along the introduction of laser to cardiovascular therapy -- Laser-thrombus interaction: from basic research to clinical utilization in the management of cardiovascular diseases -- Laser for treatment of acute coronary syndromes -- Laser for management of ST-elevation acute myocardial infarction -- Laser for revascularization of complex targets: old SVGs, CTO, left main disease, stent restenosis -- Laser utilization for synergistic technology strategy for coronary revascularization: laser and directional rotablation; laser combined with drug eluting balloon -- Laser for revascularization of peripheral arterial disease- SFA, renal, subclavian, carotid arteries -- Laser for infra-popliteal revasculariztion -- TMR- physiology, pathology and basic research concepts -- TMR-endovascular and surgical techniques and clinical outcomes -- Laser application for venous thrombosis -- Laser for IVC filter removal -- Laser for interventional electrophysiology ? extraction and removal of pacemaker and AICD leads -- Laser for treatment of cardiac arrhythmias -- Laser application for treatment of congenital heart disease -- Nursing perspectives of cardiovascular laser procedures -- Laser safety in the cardiovascular suite and the operation room -- Laser induced cardiovascular complications : mechanisms, recognition and management -- Laser in cardiovascular veterinary medicine.
  • Digital
    Donald J. Coluzzi, Steven P.A. Parker, editors.
    Springer2017
  • Digital
    edited by Patricia M. de Freitas, Alyne Simoes.
    Wiley2015
  • Digital
    Keyvan Nouri (editor).
    Springer2011
    Laser-Tissue Interactions -- Laser Safety: Regulations, Standards and Practice Guidelines -- Lasers for Treatment of Vascular Lesions -- Laser for Scars -- Laser Treatment of Leg Veins -- Lasers and Lights for Treating Pigmented Lesions -- Laser Treatment of Tattoos -- Laser for Hair Removal -- Lasers for Resurfacing -- Fractional Photothermolysis -- Plasma Resurfacing -- Sub-Surfacing Lasers -- Non-invasive Rejuvenation/Skin Tightening: Light-Based Devices -- Laser and Light Therapies for Acne -- Lasers for Psoriasis and Hypopigmentation -- Lasers and Lights for Adipose Tissue and Cellulite -- Intense Pulse Light (IPL) -- Photodynamic Therapy -- Light-Emitting Diode Phototherapy in Dermatological Practice -- Laser and Light for Wound Healing Stimulation -- Lasers in Hair Growth and Hair Transplantation -- Reflectance-Mode Confocal Microscopy in Dermatological Oncology -- Laser Clinical and Practice Pearls -- The Selection and Education of Laser Patients -- Anesthesia for Laser Surgery -- Laser Application for Ethnic Skin -- Laser Applications in Children -- Dressings/Wound Care for Laser Treatment -- Prevention and Treatment of Laser Complications -- Ethical Issues -- Medicolegal Issues (Documentation/Informed Consent) -- Psychological Aspects to Consider Within Laser Treatments -- Photography of Dermatological Laser Treatment -- Online Resources for Dermatologic Laser Therapies -- Starting a Laser Practice -- Research and Future Directions -- Laser/Light Applications in Ophthalmology: Visual Refraction -- Laser/Light Applications in Ophthalmology: Posterior Segment Applications -- Laser/Light Application in Ophthalmology: Control of Intraocular Pressure -- Laser/Light Application in Dental Procedures -- Laser/Light Applications in Otolaryngology -- Laser/Light Applications in Gynecology -- Laser/Light Applications in General Surgery -- Laser/Light Applications in Urology -- Lasers in Cardiology and Cardiothoracic Surgery -- Laser/Light Applications in Neurology and Neurosurgery -- Laser/Light Applications in Anesthesiology.
  • Digital
    Keyvan Nouri, editor.
    Springer2018
  • Digital
    Keyvan Nouri editor.
    Springer2018
    Along with its sister dermatologic volume, this comprehensive textbook of laser technology covers the use of lasers to treat vascular anomalies and lesions, control of pigmented lesions and tattoos, hair removal, acne, facial rejuvenation, Psoriasis, hypopigmented lesions and Vitiligo. Chapters are formatted in an easy to follow format with clear concise sections with bulleted summaries to highlight key points. Lasers in Dermatology and Medicine: Dermatologic Applications provides detailed explanations of when lasers can be of use how to use them across a range of medical disciplines. Clinically relevant examples are provided along with relevant images and summary boxes to highlight key points. It therefore provides a critical resource on the applications and use of lasers across medicine for both the trainee and trained clinician.
  • Digital
    Christine E. Kasper, PhD, RN, FAAN, FACSM, Tonya A. Schneidereith, PhD, CRNP, PPCNP-BC, CPNP-AC, Felissa R. Lashley, PhD, RN, FABMGG, editors.
    R2Library2016
    Today's nurses must be able to "think genetically" to help individuals and families who are affected by genetic disease or contemplating genetic testing. This book is a classic resource for nursing students and practitioners at all levels who need to acquire the knowledge and skills for using genomics in their practice. This completely updated second edition encompasses the many recent advances in genetic research and knowledge, providing essential new information on the science, technology, and clinical application of genomics. It focuses on the provision of individualized patient care based on personal genetics and dispositions. The second edition is designed for use by advanced practice nursing programs, as well as undergraduate programs. It pinpoints new developments in prenatal, maternity, and pediatric issues and supplies new information on genomics-based personal drug therapy, environmental susceptibilities, genetic therapies, epigenetics, and ethics. The text features a practical, clinically oriented framework in line with the core competencies defined by the AACN. It delivers information according to a life-span approach used in the practice setting. The second edition continues to provide basic information on genomics, its impact on health care, and genetic disorders. It covers prevention, genetic counseling and referral, neuropsychiatric nursing, and public health. The core of the text presents information on a variety of diseases that affect patients throughout the life span, with specific guidance on the nursing role. Also included are tests for a variety of diseases and information on pharmacogenomics, which enable health care providers to select the best drugs for treatment based on a patient's genetic makeup. Plentiful case study examples support the information throughout. Additionally, an instructor's package of PowerPoint slides and a test bank are provided. New to the Second Edition: Completely updated, Personal drug therapy based on genomics, Environmental susceptibilities, Prenatal detection and diagnosis, Newborns and genetic screening, Reproductive technologies, Ethical issues, Genetic therapies, Epigenetics, Includes content for graduate-level programs, PowerPoint slides and a test bank for all student levels, Key Features: Encompasses state-of-the-art genomics from a nursing perspective, Provides a practical, clinically oriented life-span approach, Covers science, technology, and clinical application of genomics, Addresses prevention, genetic testing, and treatment methods.
  • Digital
    editor, Robert S. Feder.
    Ovid2013
    Section I. LASIK fundamentals -- section II. Diagnostic equipment -- section III. Flap-making equipment -- section IV. Excimer lasers -- section V. Management of postsurgical problems -- section VI. Other surgical considerations -- section VII. Study section -- section VIII. International perspectives in refractive surgery.
  • Print
    David G. Hunter, Constance E. West.
    Status: Not Checked Out
    Basic principles -- Vergence, lenses, objects, and images -- The model eye -- Visual acuity testing -- Refraction and optical dispensing -- Lens effectivity and vertex distance -- Accommodation, presbyopia, and bifocals -- Astigmatism -- Aberrations, distortions, and irregularities -- Contact lenses -- Intraocular lenses -- Refractive surgery -- Magnification and telescopes -- Low vision -- Mirrors -- Prisms and diplopia -- Instruments -- Good people, bad optics : the dissatisfied patient -- Important formulas.
  • Digital
    Robert A. Norman, Sharad P. Paul.
    Springer2017
    This book describes a paradigm shift for all of humanity -- We are at a point where we may be the last generation that is still partially or fully natural. We are often balancing on the precipice between science and science fiction, now ready to tip the scales and slide comfortably into the future of great discoveries and wonderful changes. Many crucial and important questions are addressed in the pages of this book, including: what are the true medical and social problems facing us? Which are the highest value targets we need to focus on to ensure our best route of success? How can we protect our futures and enhance our lives by understanding what it means to be the "last natural humans" to roam this planet? The Last Natural Man combines a fascination with the history of medicine, evolutionary biology, and medical anthropology and mix it with modern medicine and science to investigate how we evolved and where we are headed. The overall result is a clear and engaging guidebook for navigating the often confusing and cloudy waters of the future of medicine and our life on Earth.‍?‍? Cultural evolution has been the major driving force over the last several thousand years and enormous in its influence compared to almost invisible changes in our physical adaptations. If cultural and religious evolution was the driver for human history, are we now entering the phase of physical transformation ? where humanity refuses to accept mortality and seeks to make changes to defeat nature. ‍In this book the authors are describing a paradigm shift of all of humanity?just as hunter-gatherers had their stellar features, the future man will have many attractive qualities, even if many artificial. We are often balancing on the precipice between science and science fiction, now ready to tip the scales and slide comfortably into the future of great discoveries and wonderful changes. But are these changes all for the good? What will being human mean.
  • Print
    Adam Richard Rosenblatt.
    Last Rights is a political, historical, and philosophical study of the scientific investigation of mass graves in the wake of genocides and other mass killings. In the mid-1980s, an independent group of anthropologists formed in Argentina to exhume the anonymous graves of "disappeared" victims of state repression. Since then, a number of human rights organizations have built on this model, assembling teams of forensic anthropologists, archaeologists, pathologists, geneticists, and other experts capable of documenting evidence of war crimes and identifying dead victims. In the 1990s, after genocidal violence erupted in both Rwanda and the disintegrating Yugoslavia, international tribunals called upon forensic experts from Latin America, the United States, and Europe to exhume mass graves in both countries, making the forensic investigation of human rights violations a global project. Since then, expectations have steadily grown among survivor communities, as well as international institutions and observers, that mass graves will be exhumed, evidence gathered, and bodies identified. Using case studies from Argentina, the former Yugoslavia, Poland, Spain, and other post-conflict nations, as well as reports, articles, memoirs, and interviews with forensic experts, this dissertation paints a detailed portrait of the purposes international forensic investigations serve. Courts and tribunals, transitional governments, victims' families and other mourners all have different stakes in discovering the truths buried in mass graves, and thus place different expectations and demands on forensic teams. This complex landscape of stakeholders has added a whole new set of priorities to the traditional conception of forensics as science used in the service of the law: among them the "humanitarian" effort to discover the fate of missing persons and return their bodies to families, the construction of an objective and scientific historical narrative, and training local forensic experts and authorities to deal with the legacy of violence. Yet forensic teams have also met with fierce objections from some families of the missing and other communities around mass graves. These objections pose a challenge to the universalism of global forensic investigation--the idea that forensic science can serve the same purposes in every post-conflict setting. However, a detailed study of the specific arguments behind these challenges can create opportunities to develop clearer explanations of what forensic investigations accomplish, as well as foster more nuanced and democratic interactions with local stakeholders. In its final chapters, the dissertation pursues a new dimension of ethical inquiry, asking what forensic investigations do for the dead victims of atrocity. Drawing on various approaches from political and moral theory, it first explores the ethical framework most familiar to international forensic teams: human rights. Human rights are a powerful language for describing the violations that have been inflicted on the now-dead victims, as well as the claims of living mourners. As a description of the guarantees that can be made to dead bodies, however, they overreach. Dead bodies can, however, be cared for in various ways, even when they are unidentified or incomplete. Many of the practices of forensic experts are already directed towards this care-giving relationship with the dead, an intimate and powerful attempt to reestablish the connections between their bodies, possessions, and their mourners, as well as to reverse the effects of violence upon them.
  • Digital
    [edited by] Chummy S. Sinnatamby.
    ClinicalKey2011
    Upper limb -- Lower limb -- Thorax -- Abdomen -- Head and neck and spine -- Central nervous system -- Osteology of the skull and hyoid bone.
  • Digital
    P. Rubin, L.S. Constine, L.B. Marks, P. Okunieff, (eds.).
    Springer2008
  • Digital/Print
    edited by Stewart Goldman, Christopher Turner.
    Digital : Springer2009
    Print2009
    Part I. Overview of brain tumor survivorship -- Introduction to brain tumor survivorship and historical perspective / Stewart Goldman and Christopher D. Turner -- Late effects of neurosurgery / Arthur J. DiPatri, Martin Pham, and Kenji Muro -- Late effects of CNS radiation therapy / Helen A. Shih, Jay S. Loeffler, and Nancy J. Tarbell -- Late effects of chemotherapy / Sridharan Gururangan -- Late effects of stem cell transplantation in brain tumor survivors / Karina Danner-Koptik, David A. Jacobsohn, and Kimberley J. Dilley -- Effect of cancer treatment on neural stem and progenitor cells / Jörg Dietrich and Santosh Kesari -- The pediatric brain tumor late effects clinic / Kimberly J. Dilley and Barbara Lockart -- Part II. Medical late effects of brain tumor treatment -- Neurological complications in adults / Michelle Monje and Patrick Y. Wen -- Neurological complications in children / Sonia Partap and Paul Graham Fisher -- Strokes among childhood brain tumor survivors / Daniel C. Bowers -- Endocrine late effects: manifestations and treatments / Jason R. Fangusaro and Elizabeth Eaumann Littlejohn -- Ocular consequences and late effects of brain tumor treatments / María E. Echevarría and Joanna L. Weinstein -- Auditory late effects of chemotherapy / Anna K. Meyer and Nancy M. Young -- Reproductive health issues in survivors of childhood and adult brain tumors / Tress Goodwin, B. Elizabeth Delasobera, and Paul Graham Fisher -- Cancer predisposition syndromes / Joanna L. Weinstein, Kanyalakshmi Ayyanar, and Melody A. Watral -- Secondary neoplasms following treatment for brain tumors / Joanna L. Weinstein, Kanyalakshmi Ayyanar, and Melody A. Watral.
  • Digital
    Shahirose Sadrudin Premji, editor.
    Springer2019
    This volume analyses the distinct care needs of late preterm infants and their parents by reflecting on the best available evidence to inform on practice and latest innovations in care. It addresses the spectrum of issues experienced by late preterm infants and their parents to ensure their health life trajectories. We define late preterm infants as those born between 34 to 36 weeks' gestational age. The book uses creative writing prompts and a narrative style to gain insight and self-reflection in and on practice to move the reader to embracing best practices. Issues such as mother's physical and emotional health, father's burden in postpartum period and neurodevelopmental outcomes of late preterm infants are specifically addressed. Areas of innovation are shared for consideration to prompt readers thinking about continuous improvement in quality of care. The book shares local and global perspectives to address the common concerns related to care of late preterm infants and their families, and to foster a partnership in promoting their health all across the globe. It is intended to any health care providers such as nurses, midwives, physicians and other allied care professionals like health visitors, community health workers.
  • Digital
    Todd Dufresne, Lakehead University, Ontario.
    Cambridge2017
    Freud is best remembered for two applied works on society, 'The Future of an Illusion' and 'Civilization and its Discontents'. Yet the works of the final period are routinely denigrated as merely supplemental to the earlier, more fundamental "discoveries" of the unconscious and dream interpretation. In fact, the "cultural Freud" is sometimes considered an embarrassment to psychoanalysis. Dufresne argues that the late Freud, as brilliant as ever, was actually revealing the true meaning of his life's work. And so while 'The Future of an Illusion', 'Civilization and its Discontents', and his final work 'Moses and Monotheism' may be embarrassing to some, they validate beliefs that Freud always held - including the psychobiology that provides the missing link between the individual psychology of the early period and the psychoanalysis of culture of the final period. The result is a lively, balanced, and scholarly defense of the late Freud that doubles as a major reassessment of psychoanalysis of interest to all readers of Freud.
  • Digital
    edited by P.A. Poole-Wilson, L. Tavazzi.
    Oxford2006
  • Digital
    Michael Y. Wang, Andrew A. Sama, Juan S. Uribe, editors.
    Springer2017
    This well-illustrated textbook is the first comprehensive and authoritative source of information on minimally invasive lateral access spine surgery. It covers all aspects of the subject, including patient selection, approach and monitoring techniques, soft tissue management, application in a variety of pathologies, technical nuances, and the prevention and management of complications. In addition, current controversies in the field are discussed and the biomechanics of lateral spinal reconstruction, the physiologic benefits, and cost implications are explained. Over the past decade, the emergence of minimally invasive lateral access spine surgery has created a revolution in spine treatment. This trend began with the introduction of extreme lateral interbody fusion, a totally new spinal procedure. In recent years, the conversion of more than 15% of lumbar spinal fusion procedures to a lateral approach has been due to the unique advantages of this approach over conventional anterior or posterior surgery. All major purveyors of spinal products and implants have entered this market enthusiastically, and all major spinal societies now conduct annual cadaveric and didactic courses to teach the technique. As use of the lateral approach in spinal surgery has become more popular, so its diversity and complexity have increased. Nevertheless, coverage in the literature is typically limited to single chapters, and the spinal surgeon seeking to achieve optimal results must rely on chance discussions with colleagues at meetings to learn the latest information. Lateral Access Minimally Invasive Spine Surgery is designed to fill this vacuum. Written by world experts on the topic, it will be an excellent resource for both beginning and experienced surgeons.
  • Digital
    Raphael C. Wong, Harley Y. Tse, editors.
    Springer2009
  • Digital
    Uri Gophna, editor.
    Springer2013
    "Although the phenomenon of lateral gene transfer has been known since the 1940s, it was the genomics era that has really revealed the extent and many facets of this evolutionary/genetic phenomenon. Even in the early 2000s with but a handful of genomes available, it became clear that the nature of microorganisms is full of genetic exchange between lineages that are sometimes far apart. The years following this saw an explosion of genomic data, which shook the "tree of life" and also raised doubts about the most appropriate species concepts for prokaryotes. This book represents the manyfold contributions of LGT to the evolution of micro and, to an extent, macroorganisms by focusing on the areas where it has the largest impact: metabolic innovations and adaptations and speciation." Back cover.
  • Digital
    Sheryl Coombs, Horst Bleckmann, Richard R. Fay, Arthur N. Popper, editors.
    Springer2014
    The Lateral Line System provides an overview of the key concepts and issues surrounding the development, evolution, neurobiology, and function of the lateral line, a fascinating yet somewhat enigmatic flow-sensing system. The book examines the historical precedence for linking the auditory and lateral line systems, its structure and development, use of the lateral line system of zebrafish as a model system, physical principles governing the response properties of the lateral line, the behavioral relevance of this sensory system to the lives of fish, and an examination of how this information
  • Digital
    [editor-in-chief], Rick A. Friedman ; [associate editors], William H. Slattery III [and others].
    Thieme MedOne Neurosurgery2012
    It is an insightfully organized text of advanced surgical techniques that will assist any training or practicing surgeon caring for those with acoustic schwannomas and other skull base pathology.
  • Digital
    Sebastian Ocklenburg, Onur Güntürkün.
    ScienceDirect2018
    The Lateralized Brain: The Neuroscience and Evolution of Hemispheric Asymmetries is an up-to-date teaching resource for neuroscience faculty members that teach courses concerning hemispheric asymmetries. The book provides students with all relevant information on the subject, while also giving aspiring researchers in the field an up-to-date overview of relevant, previous work. It is ideal for courses on hemispheric asymmetries, that is, the functional or structural differences between the left and the right hemispheres of the brain, and also highlights how the widespread use of modern neuroimaging techniques, such as fMRI and DTI has completely changed the way hemispheric asymmetries are currently investigated.
  • Digital
    edited by Havid́́án Rodríguez, Sáenz, Rogelio, Cecilia Menjívar ; with forewords by Clara E. Rodríguez, Douglas S. Massey.
    Springer2008
    Theoretical and methodological issues of Latina/o research / Nestor Rodríguez -- New Latino destinations / Manuel A. Vásquez, Chad E. Seales, and Marie Friedmann Marquardt -- Latino incorporation in the United States in local and transnational contexts / Robert Courtney Smith -- Demographic patterns : age structure, fertility, mortality, and population growth / Jorge del Pinal -- Through children's eyes : families and households of Latino children in the United States / Jennifer E. Glick and Jennifer Van Hook -- U.S. Latinos/as and the "American dream" : diverse populations and unique challenges in housing / Eileen Diaz McConnell -- Latino health paradoxes : empirical evidence, explanations, future research, and implications / Dolores Acevedo-Garcia and Lisa M. Bates -- Latino crime and delinquency in the United States / Ramiro Martinez, Jr. -- The educational experiences of Latinos in the United States / William Vélez -- Latinos in the United States labor market / Lisa Catanzarite and Lindsey Trimble -- Latino/a entrepreneurship in the United States : a strategy of survival and economic mobility / Zulema Valdez -- Income, earnings, and poverty : a portrait of inequality among Latinos/as in the United States / Alberto Dávila, Marie T. Mora, and Alma D. Hales -- Mapping the dynamic terrain of U.S. Latina/o media research / Isabel Molina Guzmán -- As the Latino/a world turns : the literacy and cultural production of transnational latinidades / Ana Patircia Rodríguez -- Religion and religiosity / Miguel A. De La Torre -- Latinos/os (in) on the border / Emily Skop, Brian Gratton, and Myron P. Gutmann -- Entre nosotras/os : theorizing, researching, and constructing cross-Latina/o relations in the United States / Gilda L. Ochoa -- Beyond gender dichotomies : toward a new century of gendered scholarship in the Latina/o experience / Maura I. Toro-Morn -- Adelante mujer : Latina activism, feminism, and empowerment / Denise A. Segura and Elisa Facio -- Latinas and Latinos, sexuality, and society : a critical sociological perspective / Gloria González-Lopez and Salvador Vidal-Ortiz -- Latino partisanship, political activity and vote choice / Kim Geron and Melissa R. Michelson -- Political orientations and Latino immigrant incorporation / Sarah Allen Gershon and Adrian D. Pantoja -- Political mobilization and activism among Latinos/as in the United States / Christian Zlolniski -- Unions and the unionization of Latinas/os in the United States / Héctor L. Delgado.
  • Digital
    a poll conducted by the Harvard School of Public Health, the Robert Wood Johnson Foundation and NPR.
  • Digital
    a poll conducted by the Harvard School of Public Health, the Robert Wood Johnson Foundation and NPR.
  • Digital
    Gianezio Paribelli, editor.
    Springer2017
  • Digital
    Deepayan Sarkar.
    Springer2008
  • Digital
    Christopher Scott Hemphill.
    This dissertation examines the law and economics of generic drug entry, and the problems that arise from specific U.S. regulatory arrangements that govern innovation and competition in the market for patented pharmaceuticals. As Chapter 1 explains, competitive entry by generic drug makers is limited by both patents and industry-specific regulation, which together provide the means for brand-name drug makers to avoid competition and thereby recoup large investments in research, development, and testing. At the same time, the complex rules of the Hatch-Waxman Act furnish a pathway by which generic drug makers may challenge the validity or scope of brand-name patents, with a view to entering the market with a competing product prior to patent expiration. The subsequent chapters examine several aspects of the competitive interaction between brand-name and generic drug makers. Chapter 2 analyzes settlements of patent litigation between brand-name and generic drug makers, in which the brand-name firm pays the generic firm in exchange for delayed market entry. Such pay-for-delay settlements are an important, unresolved question in U.S. antitrust policy. The analysis reveals that the pay-for-delay settlement problem is more severe than has been commonly understood. Several specific features of the Act--in particular, a 180-day bounty granted to certain generic drug makers as an incentive to pursue pre-expiration entry--widen the potential for anticompetitive harm from pay-for-delay settlements, compared to the usual understanding. In addition, I show that settlements are "innovation inefficient" as a means of providing profits and hence ex ante innovation incentives to brand-name drug makers. To the extent that Congress established a preferred tradeoff between innovation and competition when it passed the Act, settlements that implement a different, less competition-protective tradeoff are particularly problematic from an antitrust standpoint. Chapter 3 synthesizes available public information about pay-for-delay settlements in order to offer a new account of the extent and evolution of settlement practice. The analysis draws upon a novel dataset of 143 such settlements. The analysis uncovers an evolution in the means by which a brand-name firm can pay a generic firm to delay entry, including a variety of complex "side deals" by which a brand-name firm can compensate a generic firm in a disguised fashion. It also reveals several novel forms of regulatory avoidance. The analysis in the chapter suggests that, as a matter of institutional choice, an expert agency is in a relatively good position to conduct the aggregate analysis needed to identify an optimal antitrust rule. Chapter 4 examines the co-evolution of increased brand-name patenting and increased generic pre-expiration challenges. It draws upon a second novel dataset of drug approvals, applications, patents, and other drug characteristics. Its first contribution is to chart the growth of patent portfolios and pre-expiration challenges. Over time, patenting has increased, measured by the number of patents per drug and the length of the nominal patent term. During the same period, challenges have increased as well, and drugs are challenged sooner, relative to brand-name approval. The analysis shows that brand-name sales, a proxy for the profitability of the drug, have a positive effect on the likelihood of generic challenge, consistent with the view that patents that later prove to be valuable receive greater ex post scrutiny. The likelihood of challenge also varies by patent type and timing of expiration. Conditional on sales and other drug characteristics, drugs with weaker patents, particularly those that expire later than a drug's basic compound patent, face a significantly higher likelihood of challenge. Though the welfare implications of Hatch-Waxman patent challenge provisions are complicated, these results suggest these challenges serve a useful purpose, in promoting scrutiny of low quality and late-expiring patents.
  • Print
    Johnson, Peter.
    Status: Not Checked Out
  • Digital/Print
    issued by Physical Therapy Examining Committee, Board of Medical Quality Assurance.
    Digital : Google Books1979-
    Print1979-
  • Digital
    edited by Catherine Picart, Frank Caruso, and Jean-Claude Voegel.
    Wiley2015
  • Digital
    edited by Loralie J. Langman and Chistine L.H. Snozek.
    Springer2012
    Introduction to drug testing : the expanding role of mass spectrometry / Catherine Hammett-Stabler and Steven W. Cotten -- LC-MS vs. GC-MS, online extraction systems, advantages of technology for drug screening assays / Pierre Marquet -- LC-MS/MS techniques for high-volume screening of drugs of abuse and target drug quantitation in urine/blood matrices / Jeff C. Eichhorst [and others] -- Benzodiazepines and metabolites from biological fluids by liquid chromatography electrospray tandem mass spectrometry / Cynthia L. Morris-Kukoski, Jason E. Schaff, and Louis J. Reda -- Opiate screening and quantitation in urine/blood matrices using LC-MS/MS techniques / Jeff C. Eichhorst [and others] -- Synthetic opioid analysis by LC-MS/MS / David M. Garby and Lynn A. Cheryk -- Determination of cannabinoids using liquid chromatography with mass spectrometric detection / Oscar Quintela and Dennis J. Crouch -- Cocaine and metabolites by LC-MS/MS / Christine L.H. Snozek, Matthew W. Bjergum, and Loralie J. Langman -- Quantitation of amphetamine-type stimulants by LC-MS/MS / Robert A. Middleberg and Joseph Homan -- Detection of prohibited substances by liquid chromatography tandem mass spectrometry for sports doping control / Brian D. Ahrens, Borislav Starcevic, and Anthony W. Butch -- LC-MS/MS screen for xenobiotics and metabolites / Francois-Ludovic Sauvage and Pierre Marquet -- Qualitative identification of rodenticide anticoagulants by LC-MS/MS / Robert A. Middleberg and Joseph Homan -- Hypoglycemic agent screening by LC-MS/MS / Eric W. Korman, Loralie J. Langman, and Christine L.H. Snozek -- LC-MS/MS method for the detection of common laxatives / Robert A. Middleberg and Joseph Homan -- Simultaneous determination of cyclosporine, sirolimus, and tacrolimus in whole blood using liquid chromatography-tandem mass spectrometry / Uttam Garg, Ada Munar, and C. Clinton Frazee III -- Quantification of tricyclic antidepressants using UPLC-MS/MS / Kamisha L. Johnson-Davis [and others] -- Quantitation of first- and second-generation antipsychotics by LC-MS/MS / Elizabeth R. Kiely and Heather M. Antonides -- Analysis of selected anticonvulsants by high performance liquid chromatography-tandem mass spectrometry / Jennifer A. Collins and Gregory C. Janis -- Therapeutic drug monitoring of tamoxifen using LC-MS/MS / Simone M. Tchu, Kara L. Lynch, and Alan H.B. Wu.
  • Digital
    edited by Pedro R. Cutillas, John F. Timms.
    Springer2010
    Approaches and applications of quantitative LC-MS for proteomics and activitomics / Pedro R. Cutillas and John F. Timms -- Overview of quantitative LC-MS techniques for proteomics and activitomics / John F. Timms and Pedro R. Cutillas -- Instrumentation for LC-MS/MS in proteomics / Robert Chalkley -- Bioinformatics for LC-MS/MS-based proteomics / Richard J. Jacob -- Analysis of post-translational modifications by LC-MS/MS / Hannah Johnson and Claire E. Eyers -- In-depth analysis of protein phosphorylation by multidimensional ion exchange chromatography and mass spectrometry / Maria P. Alcolea and Pedro R. Cutillas -- Mapping of phosphorylation sites by LC-MS/MS / Bertran Gerrits and Bernd Bodenmiller -- Analysis of carbohydrates on proteins by offline normal-phase liquid chromatography MALDI-TOF-MS/MS / Theodora Tryfona and Elaine Stephens -- Selected reaction monitoring applied to quantitative proteomics / Reiko Kiyonami and Bruno Domon -- Basic design of MRM assays for peptide quantification / Andrew James and Claus Jorgensen -- Proteome-wide quantitation by SILAC / Kristoffer T.G. Rigbolt and Blagoy Blagoev -- Quantification of proteins by iTRAQ / Richard D. Unwin -- Quantification of proteins by label-free LC-MS/MS / Yishai Levin and Sabine Bahn -- Protocol for quantitative proteomics of cellular membranes and membrane rafts / Andrew J. Thompson and Ritchie Williamson -- Organelle proteomics by label-free and SILAC-based protein correlation profiling / Joern Dengjel, Lis Jakobsen, and Jens S. Andersen -- Mapping protein-protein interactions by quantitative proteomics / Joern Dengjel, Irina Kratchmarova, and Blagoy Blagoev -- Analysis of serum proteins by LC-MS/MS / Sarah Tonack, John P. Neoptolemos, and Eithne Costello -- Urinary proteome profiling using 2D-DIGE and LC-MS/MS / Mark E. Weeks -- Analysis of peptides in biological fluids by LC-MS/MS / Pedro R. Cutillas -- Quantification of protein kinase activities by LC-MS / Maria P. Alcolea and Pedro R. Cutillas -- A protocol for top-down proteomics using HPLC and ETD/PTR-MS / Sarah R. Hart.
  • Digital
    Paul Mushak.
    ScienceDirect2011
    The book presents a detailed assessment of the health science of lead and the human health risk assessment models for lead's human health impacts, followed by an account of various regulatory efforts in the United States and elsewhere to eliminate or reduce human toxic exposures to lead. The science of lead as presented here covers releases of lead into the environment, lead's movement through the environment to reach humans who are then exposed, and the spectrum of toxic effects, particularly low-level toxic effects, on the developing central nervous system of the very young child. The section on human health risk assessment deals with quantifying not only the dose-response relationships that underlie toxic responses to lead in sensitive populations but also with the likelihood of toxic responses vis-vis environmental lead at some level of exposure. This section includes a treatment of computer models of lead exposure, particularly those that use lead in whole blood as a key measure. Various models convert lead intake via various body compartments into measures of body lead burden. Such measures are then directly related to severity of injury. The final section of the book deals with past and present regulatory efforts to control lead releases into the human environment. Current control efforts present a mixed picture. The most problematic issue is the continued presence of lead paint in older housing and lead in soils of urban and mining industry communities. Comprehensive assessment of the three major facets of the public health problem of lead: the voluminous science, the risk assessment approaches, and approaches to controlling lead as a public health problem. Integration of the above three elements to provide a coherent whole Provides a single source of information that will be extremely valuable to all professionals working in areas impacted by this toxic substance.
  • Digital
    NLM2016

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Large number of high quality software and database programming titles from O'Reilly. Other software titles are also available from Sams and Prentice Hall. Limited to 7 concurrent users.Vast collection of software and database programming titles from multiple publishers, including Microsoft Press.Largest provider of engineering-related eBooks; includes titles in computer science and biomedical engineering.Over 4,000 full-text e-books covering scientific and technical information from CRC Press and others. Many handbooks and single volume reference sources.Includes peer-reviewed life science and biomedical research protocols compiled from Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and Springer Laboratory Manuals.Contains full text access to selected biomedical and nursing books.

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