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  • Book
    Eugenie S. Kleinerman, editor.
    Summary: "Current Advances in Osteosarcoma summarizes molecular and genetic characteristics, new therapeutic ideas, and biological characteristics that have been uncovered in this field over the past 10 years. Osteosarcoma is an aggressive malignant neoplasm and is the most common histological form of bone cancer. Osteosarcoma accounts for approximately 56% of new bone tumors, making it the most primary malignant bone tumor in children and adolescents. The lungs are the most common site of metastases and once osteosarcoma spreads to the lungs, it is very difficult to treat. In order to improve the outcome of this disease, the biology of osteosarcoma needs to be better understood. There are numerous investigators around the world who have made seminal discoveries about the important molecular pathways and genetic alterations that contribute to the development and metastases of osteosarcoma. Other investigators have proposed novel therapeutic strategies including some based on the molecular and genetic phenotype of the disease. This volume will provide a comprehensive review of these new discoveries in one singular text, which will help move the field forward."

    Contents:
    Historical perspective on the introduction and use of chemotherapy for the treatment of osteosarcoma / Norman Jaffe
    Wnt signaling in osteosarcoma / Carol H Lin, Tao Ji, Cheng-Fong Chen, Bang H Hoang
    Receptor tyrosine kinases in osteosarcoma: not just the usual suspects / Ashley N. Rettew, Patrick J Getty, and Edward M. Greenberg
    Understanding the role of notch in osteosarcoma / Madonna M McManus, Kurt R Weiss, and Dennis PM Hughes
    Developmental pathways highjacked by osteosarcoma / Yi Zhang, Jared R Mortus, and Dennis PM Hughes
    MicroRNAs in osteosarcomagenesis / Lisa A Kafchinski and Kevin B Jones
    RECQ DNA helicases and osteosarcoma / Linchao Lu, Weidong Jin, Hao Liu, and Lisa L Wang
    Autophagy in osteosarcoma / Janice Santiago O'Farrill and Nancy Gordon
    Her-2 involvement in osteosarcoma / Jonathan Gill, David Geller, and Richard Gorlick
    Role of ezrin in osteosarcoma metastasis / Ling Ren and Chand Khanna
    Participation of the Fas/FasL signaling pathway and the lung microenvironment in the development of osteosarcoma lung metastases / Gangxiong Huang, Kazumasa Nishimoto, Yuanzheng Yang, and Eugenie S Kleinerman
    Zebrafish as a model for human osteosarcoma / AB Mohseny and Pancras CW Hogendoorn
    Using canine osteosarcoma as a model to assess efficacy of novel therapies: can old dogs teach us new tricks? / Carlos O Rodriguez
    Oncolytic viruses for potential osteosarcoma therapy / Pooja Hingorani, Valerie Sampson, Christina Lettieri, E. Anders Kolb
    Il-11r[alpha]: a novel target for the treatment of osteosarcoma / Valerae Lewis
    Bone-seeking radiopharmaceuticals as targeted agents of osteosarcoma: samarium-153-edtmp and radium-223 / Peter M Anderson, Vivek Subbiah, and Eric Rohren
    Muramyl tripeptide-phophatidyl ethanolamine encapsulated in lipomes (L-MTP-PE) in the treatment of osteosarcoma / Paul A Meyers
    Genetically modified T-cell therapy for osteosarcoma / Christopher DeRenzo and Stephen Gottschalk
    Natural killer cells for osteosarcoma / Nidale Tarek, and Dean A Lee.
    Digital Access Springer 2014