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all 1023 "E" titles


  • E. coli gene expression protocols 2002
    Springer Protocols
  • A textbook in the Illustrated Colour Text series on ENT, aimed at medical students and junior doctors. Concise presentation of ENT in the attractive ICT format - clear line diagrams, colour photos of clinical conditions, summary boxes etc. Covers a topic which is important in primary care - medical students and junior doctors are motivated to buy a book in this area. Basic anatomy and physiology is reviewed - useful revision for students in clinical years. Comprehensive coverage of both presenting symptoms and specific diseases, with more detail on the commoner conditions. Clear description of examination and investigation techniques.
  • Ear -- Nose, nasal sinuses, and face -- Mouth and pharynx -- Larynx and hypopharynx -- Voice, speech, and language -- Tracheobronchial tree -- Esophagus -- Neck (including the thyroid gland) -- Salivary glands.
  • Ear reconstruction 2013
    Ear reconstruction is required in a variety of patients, including especially those with congenital anomalies and associated deformities. In this book, a renowned practitioner in ear reconstruction explains the approaches that he has personally developed over the past 40 years in order to improve surgical results and also presents important new concepts. The proposed techniques offer tailored solutions to specific problems and are applicable in settings including severe microtia, moderate microtia, anotia, traumatic amputation, and unsatisfactory prominent ear surgery. Complications during and after ear reconstruction are also discussed, with guidance on their treatment. Throughout the book, the aim of the author is to share the fruits of his extensive experience with fellow surgeons in an informative and practically oriented way. The clearly written text is complemented by numerous helpful color photographs.
  • Ear surgery 2008
    Otosclerosis Surgery Complications, p. 1-12 -- Tympanoplasty/Ossiculoplasty, p. 13-27 -- Surgery for Chronic Otitis Media, p. 29-31 -- Complications of Chronic Otitis Media, p. 33-42 -- Petrous Apex Lesions, p. 43-53 -- Cholesteatoma, p. 55-60 -- External Auditory Canal Lesions, p. 61-65 -- Spontaneous Cerebral Spinal Fluid Otorrhea, p. 67-75 -- Facial Nerve Surgery, p. 77-88 -- Surgery for Vertigo, p. 89-98 -- Tumor Surgery, p. 99-110 -- Cochlear Implant Surgery, p. 111-115 -- Differential Diagnosis of Unilateral Serous Otitis Media, p. 117-120.
  • Print Material
  • The contemporary context of young adulthood. The contemporary context of young adulthood in the USA : from demography to development, from private troubles to public issues / Richard A. Settersten Jr. ; Transition to adulthood, parental support, and early adult well-being : recent findings from the youth development study / Jeylan T. Mortimer ; "First principles" : components, holism, and context of the transition to adulthood / Ross Macmillan ; Young adults in a wireless world / Eva S. Lefkowitz, Shelley N. Vukman, and Eric Loken -- Parent-child relationships and successful transitions. Relationships between young adults and their parents / Karen L. Fingerman ... [et al.] ; The implications of family context for the transition to adulthood / Monica Kirkpatrick Johnson and Janel Benson ; Child well-being and the long reach of family relationships / Kelly Musick and Ann Meier ; Young adults' "need" : in the eye of the beholder? / D. Wayne Osgood and Sonja E. Siennick -- Romantic and sexual relationships. Developmental shifts in the character of romantic and sexual relationships from adolescence to young adulthood / Peggy C. Giordano .. [et al.] ; Challenges in charting the course of romantic relationships in adolescence and emerging adulthood / Frank D. Fincham ; I just want your kiss? : sexual relationships in young adulthood / Kelly Raley -- Family contexts and timing of fertility. Becoming a parent : the social contexts of fertility during young adulthood / Kathryn Edin and Laura Tach ; Childbearing among cohabiting women : race, pregnancy, and union transitions / Daniel T. Lichter ; Understanding young fertility in the context of economic disadvantage / Marcia J. Carlson -- The study of young adulthood. New horizons in research on emerging and young adulthood / Jeffrey Jensen Arnett ; The role of family context in early adulthood : where we've been and where we're going / Jessica Halliday Hardie and Christine E. Stanik.
  • Also available: Print – 2011
    More than 40 articles provide an extensive coverage of advances over the last three years of research on subarachnoid hemorrhage-induced brain injuries and cerebral vasospasm. Early brain injury, the new frontier of subarachnoid hemorrhage research, which may be a key contributor to the high mortality and morbidity, promotes collaborative efforts from neurosurgery, neurology, neuro-ICU into other interrelated fields and basic neurosciences. For the first time, subarachnoid hemorrhage research is almost equally divided by early brain injury and cerebral vasospasm, mechanistic investigations and therapeutic approaches, demonstrating a translational feature of the future direction.
  • Print Material
    Contents. - pt. 1. Embryos of the first five weeks (to stage 15).
  • Early disease detection v. 1-2, 1970-71.
    Print Material
  • Clinically relevant study end points in rectal cancer -- Neoadjuvant treatment in rectal cancer : do we always need radiotherapy or can we risk assess locally advanced rectal cancer better? -- Treatment dilemmas in patients with synchronous colorectal liver metastases -- Pancreatic surgery : beyond the traditional limits -- Adjuvant therapy for pancreatic cancer -- Radiotherapy of the pancreas : state of the art in 2012 -- Adenocarcinoma of the GEJ : gastric or oesophageal cancer? -- Why is there a change in patterns of GE cancer? -- Endoscopic treatment for esophageal squamous cell carcinoma -- Open or minimally invasive resection for oesophageal cancer? -- Choosing the best treatment for esophageal cancer -- Multimodal therapy of GEJ cancer : when is the definitive radiochemotherapy the treatment of choice? -- Radiotherapy of gastroesophageal junction cancer -- Optimizing neoadjuvant chemotherapy through the use of early response evaluation by positron emission tomography -- Optimal surgery for gastric cancer : is more always better? -- Can adjuvant chemoratiotherapy replace extended lymph node dissection in gastric cancer? -- Predicting the response to chemotherapy in gastric adenocarcinoma : who benefits from neoadjuvant chemotherapy? -- Prediction of response and prognosis by a score including only pretherapeutic parameters in 410 neoadjuvant treated gastric cancer patients -- Adjuvant chemotherapy : an option for Asian patients only? -- Selecting the best treatment for an individual patient.
  • "This Recent Results in Cancer Research volume provides an up-to-date overview of the multidisciplinary management of locally confined rectal cancer as well as colorectal cancer with synchronous resectable liver metastases. The contents comprise the majority of the invited contributions from the Second St. Gallen EORTC Gastrointestinal Cancer Conference, held on 6-8 March 2014 in St. Gallen, Switzerland. Written by some of the world's leading experts in the imaging, endoscopy, pathology, molecular biology, surgery, radiotherapy, and medical oncology of rectal cancer and liver metastases, the chapters offer a comprehensive view on the latest recommendations in diagnosis and multidisciplinary treatment. Every clinician involved in the care of patients with rectal cancer will find this book interesting and helpful."--Publisher's description.
  • Also available: Print – 2001
  • Also available: Print – 2006
    1. The Developmental origins of health and disease: the breadth and importance of the concept / Peter D. Gluckman and Mark A. Hanson -- 2. Developmental origins of cardiovascular disease, type 2 diabetes, and obesity in humans / Caroline H.D. Fall -- 3. Studies of twins: what can they tell us about the developmental origins of adult health and disease? / Ruth Morley, Terence Dwyer, and John B. Carlin -- 4. Prenatal programming of human motor function / Julia B. Pitcher, David J. Henderson-Smart, and Jeffrey S. Robinson -- 5. Adaptive responses of early embryos to their microenvironment and consequences for post-implantation development / Jeremy Thompson, Michelle Lane, and Sarah Robertson -- 6. Modification of epigenetic state through dietary manipulation in the developing mammalian embryo / Nicola Vickaryous and Emma Whitelaw -- 7. Critical experiments to determine if early nutritional influences on epigenetic mechanisms cause metabolic imprinting in humans / Robert A. Waterland -- 8. Manipulation of the maternal diet in rat pregnancy: different approaches to the demonstration of the programming principle / Simon C. Langley-Evans [et al.] -- 9. Programming hypertension-animal models: causes and mechanisms / Kate M. Denton, Michelle M. Kett, and Miodrag Dodic -- 10. Developmental programming of cardiovascular dysfunction / Lucilla Poston, James A. Armitage, and Paul D. Taylor -- 11. Kidney development and fetal programming / Karen M. Moritz and Luise A. Cullen-McEwen -- 12. Programming of obesity-experimental evidence / Bernhard H. Breier, Stefan O. Krechowec, and Mark H. Vickers -- 13. Perinatal programming of adult metabolic homeostasis: lessons from experimental studies / Kathryn l. Gatford ... [et al.] -- 14. Programming effects of excess glucocorticoid exposure in late gestation / Timothy J.M. Moss and Deborah M. Sloboda -- 15. Programming effects of moderate and binge alcohol consumption / Jeff Schwartz and Luke C. Carey -- 16. Vitamin D in pregnancy and offspring health / Marianne Tare, Helena C. Parkington, and Ruth Morley -- 17. The Fetal origins of adult mental illness / Laura Bennet and Alistair J. Gunn -- 18. Hypoxia, fetal growth and developmental origins of health and disease / Dino A. Giussani.
  • Foreword / J.H. Schwartz, I. Tattersall -- Szombathy's excavations in the Mladeč Cave and the first presentations of the results / W. Antl-Weiser -- In search of prototypes - historical soft-tissue reconstructions of Mladeč 1 / M. Teschler-Nicola -- The structure of the cave, stratigraphy, and depositional context / J.A. Svoboda -- The Upper Paleolithic finds from the Mladeč Cave / M. Oliva -- Taphonomic aspects of the human remains from the Mladeč Caves / M. Teschler-Nicola -- Large mammal remains from the Mladeč Caves and their contribution to site formation processes / M. Pacher -- ¹⁴C dating of early Upper Palaeolithic human and faunal remains from Mladeč / E.M. Wild ... [et al.] -- Inventory and photo-documentation of the Mladeč hominid remains / M.H. Wolpoff ... [et al.] -- Aurignacian male crania, jaws and teeth from the Mladeč Caves, Moravia, Czech Republic / D.W. Frayer ... [et al.] -- Aurignacian female crania and teeth from the Mladeč Caves, Moravia, Czech Republic / M.H. Wolpoff, D.W. Frayer and J. Jelínek -- Electronic segmentation methods reveal the preservation status and otherwise unobservable features of the Mladeč 1 cranium / H. Prossinger and M. Teschler-Nicola -- The Mladeč 3 infant / N. Minugh-Purvis, Th. Bence Viola and M. Teschler-Nicola -- The human postcranial remains from Mladeč / E. Trinkaus ... [et al.] -- Lost, destroyed or misidentified postcranial specimens from Mladeč / M.H. Wolpoff, D.W. Frayer and J. Jelínek -- External geometry of Mladeč neurocrania compared with anatomically modern humans and Neanderthals / G.W. Weber ... [et al.] -- Pathological alterations and traumas in the human skeletal remains from Mladeč / M. Teschler-Nicola ... [et al.] -- No evidence of Neandertal mtDNA contribution to early modern humans / D. Serre ... [et al.] -- Non-destructive determination of ⁸⁷Sr/⁸⁶Sr isotope ratios in early Upper Paleolithic human teeth from the Mladeč Caves - preliminary results / T. Prohaska ... [et al.].
  • Endoscopic Screening and Surveillance-Indications and Standards -- Histopathology of Early Mucosal Neoplasias-Morphologic Carcinogenesis in the GI Tract -- Principles of Endoscopic Resection-Diagnostic and Curative Resection of Mucosal Neoplasias -- Endoscopic Detection and Analysis of Mucosal Neoplastic Lesions -- Enhanced Imaging and Tumor Morphology -- High-resolution Endoscopic Ultrasound -Clinical T-staging of Mucosal Neoplasms -- Squamous Cell-lined Esophagus and Hypopharynx -- Mucosal Neoplasias -- Columnar Epithelium-lined (Barrettś) Esophagus -- Mucosal Neoplasias -- Stomach-Mucosal Neoplasias -- Duodenum and Small Bowel -- Mucosal Neoplasias -- Colorectum-Mucosal Neoplasias -- Chronic Inflammatory Bowel Disease in Remission -Mucosal Neoplasias.
  • Animal studies of the effects of early nutrition on long-term health / Harding, J.E. ... [et al.] -- Dietary lipid quality and long-term outcome / Novak, E.M., Keller, B.O. and Innis, S.M. -- How proteins improve the development of preterm infants / Corpeleijn, W.E. ... [et al.] -- The knowns and unknowns of human milk banking / Simmer, K. -- Short- and long-term effects of probiotics administered early in life / Szajewska, H. -- New findings from the feeding infants and toddlers study 2008 / Siega-Riz, A.M. ... [et al.] -- Weaning practices in other parts of the world : case study India / Agarwal, K.N. -- Weaning practices in other parts of the world : case study Russia / Baturin, A.K. -- Micronutrient deficiencies and effect of supplements on correcting them / Zlotkin, S. -- Food allergy and complementary feeding / Shreffler, W.G. and Radano, M. -- Early feeding : setting the stage for healthy eating habits / Mennella, J.A. and Ventura, A.K. -- Early feeding practices and development of food allergies / Lack, G. and Penagos, M. -- Learning to prefer the familiar in obesogenic environments / Birch, L.L. and Anzman-Frasca, S. -- Early feeding practices and their impact on development of celiac disease / Fasano, A. and Catassi, C. -- Infant feeding practices and subsequent development of adipose tissue / Stettler, N. -- Early life nutrition and bone development in children / Jones, G. -- IGF-I signaling and effects on longevity / Holzenberger, M.
  • Also available: Print – 2005
    What is the EU infant nutrition cluster? -- Early nutrition and its later consequences: new opportunities -- The developmental origins of adult health and well-being -- Long term effects of breastfeeding on the infant and mother -- Experimental evidence for long-term programming effects of early diet -- Candidate genes for obesity--how might they interact with environment and diet? -- Rate of growth in early life: a predictor of later health? -- Protective effect of breast-feeding against obesity in childhood-- Discussion forum: from innovation to implementation -- Challenges and opportunities in pan-European collaboration for researchers from Central and Eastern Europe -- Best practice in communicating the results of European research to the public -- Longterm effects of pre- and postnatal exposure to low and high dietary protein levels / Cornelia C. Metges -- Protein intake in the first year of life: a risk factor for later obesity? -- The role of long-chain poly-unsaturated fatty acids (LCPUFA) in growth and development -- Experimental models for studying perinatal lipid metabolism -- Effect of N-3 polyunsaturated fatty acid supplementation in pregnancy: the Nuheal trial -- Young researchers' workshop -- Consumer needs regarding dietetic products for pregnant and lactating women and for baby foods -- Focus group: breakfast meeting: SMES and their co-operation with academia -- Ethical issues in perinatal nutrition research -- Early programming of diabetes risk--an introduction -- Early nutrition and later diabetes risk -- Is type 1 diabetes a disease of the gut immune system triggered by cow's milk insulin? -- Gluten-free diet in subjects at risk for type 1 diabetes: a tool for delaying progression to clinical disease? -- Insulin like growth factor regulation of body mass in breastfed and milk formula fed infants -- Inverse association between trans isomeric and long-chain polyunsaturated fatty acids in erythrocyte membrane lipids in pregnant women -- Comparison of essential fatty acid status among German, Hungarian and Spanish women at mid-gestation -- Trans isomeric fatty acids as confounding variables in studies on perinatal LC-PUFA supply -- An eight years prospective study of iron deficiency anaemia in infancy -- New insights in the potential mechanism of action of nucleotides to modulate immunity -- Thriving of malnourished breastfed infants after additional formula milk feeding -- Role of mammary gland lipoprotein lipase in the availablilty of polyunsaturated fatty acids for milk synthesis -- Is the crying behaviour in infants up to the age of 3 months influenced by the type of early nutrition? -- Dietary gangliosides: beneficial effects for the neonate and potential mechanism of action -- Leptin in breast-fed and formula-fed infants -- Dietary fatty acids during pregnancy determines maternal fatty acid profile during late pregnancy and their availability to the fetus even during fasting condtions -- Effects of oil-supplemented diets on liver expression of PPAR alpha-related genes in pregnant rats -- Effect of a new infant formula enriched with prebiotics, probiotics, nucleotides and LC-PuFA on recovery after infection -- Does habitual protein intake in early childhood influence age and body mass index at adiposity rebound? -- Dietary compliance in diabetes prevention project in Finland -- Changes of plasma fatty acid profile and antioxidant vitamins during normal pregnancy -- Optimal design for the recruitment of participants as a factor for the effective implementation of a clinical trial -- The effect of ponderal index on plasma concentration of insulin-like growth factor-1 (IGF-1) in neonatal pigs -- Effects of prenatal exposure to low and high dietary protein levels on maternal and fetal amino acid metabolism in rats -- Cow's milk introduction in Spanish infants -- Longer term effects of early cholesterol intake on cholesterol biosynthesis and plasma lipids: a randomized clinical trial -- Patterns of growth and energy utilization of the diet after a period of dietary restriction during the weaning period -- Infant formula feeding pattern and weaning introduction in Spanish infants -- Visual evoked potentials in infants after dietary supply of docosahexaenoic acid and 5-methyltetrahydrofolate during pregnancy -- Electronic data capture and use of internet technologies in a double-blind randomised intervention trial -- Breastfeeding and baby friendly hospital initiative in Slovenia -- Nutritional status in young adults with screen-detected silent/sub-clinical coeliac disease -- Liporotein lipase (LPL) MRNA expression in placentas from normal and IUGR (intrauterine growth restricted) pregnancies by real-time PCR -- Maternal fasting effect on neonatal health -- The quality of schoolchildren's nutrition in Serbia -- Tendency towards obesity in Sydney school children -- Monitoring and supervising a dietary intervention trial using modern data processing system -- Analysis of drop-outs in a longitudinal study -- Recruitment strategies of the Spanish group in the "EU childhood obesity: programming by infant nutrition" -- Diet and nutritional risk factors in schoolchildren -- Influence of two forms of caseinophosphopeptide on iron bio availability -- Model of childhood obesity primary prevention programme -- Problems related to recruitment of participants for the triger project -- Vitamin D status at birth in Brussels--preliminary results -- Obesity among young adolescent Kuwaitis -- Dynamic changes in adiposity from fetal to postnatal life are involved in the adult metabolic syndrome associated with reduced fetal growth -- Excess fetal adiposity is associated with programming of placental lipid genes -- Appetite control in breastfed and formula fed infants -- What are the Danone Institutes.
  • Also available: Print – 2009
  • Early writings v. 1-, 1975-
    Print Material
    v. 2. Genitality in the theory and therapy of neurosis.
  • User-friendly and well organized, Easy EMG is designed to help residents learn the fundamental principles of electrodiagnostic testing (including nerve conduction studies and needle EMG). This one-of-a-kind resource offers expert guidance on performing and interpreting EMGs, as well as how to test the most common conditions encountered in daily practice. At-a-glance tables combine with clear illustrations and a pocket-sized format to make Easy EMG ideal for on-the-go reference!
  • Easy injections 2007
    Introduction to injections -- Medications and injection supplies -- Joints -- Tendons -- Bursae -- Nerves -- Trigger point injections -- Botulinum toxin -- Prolotherapy -- Acupuncture -- Sympathetic injections -- Spinal injections.
  • Print Material
    Perspectives -- Introduction -- 1. Classification -- 2. Epidemiology -- 3. Etiology and pathogenesis -- 4. Diagnosis -- 5. General management principles -- 6. Treatment of anorexia -- 7. Treatment of bulimia -- 8. Course and prognosis -- 9. Other eating disorders -- 10. Research areas -- 11. Case studies -- Useful resources -- Index.
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  • Eating disorders, addictions, and substance use disorders are each challenging in their own right, but they also commonly co-occur, causing major challenges for clinicians. Emerging research suggests that there are common substrates at the neuroanatomical, neurochemical, and psychological levels. While randomized controlled trials have revealed a number of effective psychotherapeutic and psychopharmacologic treatments for the individual conditions, little is known about integrative interventions for these comorbidities. This book presents cutting-edge research on the overlap of these complex disorders and reviews integrative assessment strategies and treatment approaches, including enhanced cognitive behavioral therapy, dialectical behavior therapy, abstinence approaches, motivational enhancement, mindfulness meditation, and pharmacotherapy. The issue of whether eating-disordered behaviors such as dieting, binge eating, and excessive exercise are merely other forms of addictive behavior is examined. The authors argue both for and against the concept of food addiction in research, clinical treatment, and public policy.
  • At least 40 skin signs are associated with eating disorders (EDs), and some of them are considered guiding signs because they are indicative of an otherwise hidden ED. These skin signs may arise due to starvation, self-induced vomiting, drug consumption, and concomitant psychiatric illness. The role of the dermatologist in this context is to suspect the presence of a hidden ED based on the guiding signs. With this in mind, the most important specialists in the field come together in this book to document all of the dermatological aspects of EDs. General topics such as classification of EDs, epidemiology, and medical complications are first addressed, and skin signs attributable to various causes are then discussed in a series of detailed chapters. Characteristic changes in the hair, nails, and oral cavity are also carefully documented. The closing chapters address various other related issues of interest, including pain sensitivity in patients with EDs and the effects of anorexia nervosa on skin thickness and skin collagen. Eating Disorders and the Skin will be an invaluable source of up-to-date information for both novice and experienced dermatologists, as well as other practitioners with an interest in EDs, psychiatrists, and nurses.
  • "Foreword When I was a young woman being treated for an eating disorder, certain assumptions were made: if you had an eating disorder, you would be a white adolescent girl from a family with a controlling mother and an absent father. You would display a passive personality and low self-esteem. You would in all likelihood have signs of depression; whether you did or not, you would probably be treated for it. Your treatment team would see and treat you as childish and immature, and hold a variety of vague and often unfounded opinions about who you were, where you'd been, and what kind of chances of recovery you had. Those chances were considered, almost across the board, very low indeed. I was treated for eating disorders in the 1980s and 1990s. The medical and therapeutic understanding of the etiology, nature, and treatment of disordered eating and body image had not changed markedly since the early days of eating disorder research 20 years before. Likewise, the limited understanding of the demographics of eating disordered populations ensured that thousands would go undiagnosed and untreated. While the eating disordered population exploded, research and treatment providers held fast to their notions of what they were dealing with and how they should proceed. Their abysmal success rates bewildered them; they attributed these low rates of recovery to the intractable, probably incurable nature of the diseases. This second edition of Eating Disorders in Women and Children: Prevention, Stress Management, and Treatment is being released into a therapeutic community that has changed in many critical ways, and I believe the community will see further change as a result of the research done here"--Provided by publisher.
  • A synthesis of the best available evidence on diagnosis, management and treatment of frequent and high-cost problems occurring in primary care, inpatient and emergency department settings. Includes the top conditions; recommends a course of action for diagnosis, disease management and drug therapy.
  • Introduction -- Roles of EBNA1 at EBV Episomes -- EBNA1-DNA Interactions -- EBNA1 Contributions to EBV-Associated Tumours -- Cellular Effects of EBNA1 -- Conclusion.
  • The Overview of Needs and Requirements covers the costs of the Ebola response and preparedness activities. The needs and requirements are based on the latest information available from each of the most affected countries. The national plans and budgets comprise the framework and the Overview of Needs and Requirements defines the contributions planed by the UN system as well as the major international civil society organizations.
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    The ECG in healthy people -- The ECG in patients with palpitations and syncope -- The ECG in patients with chest pain -- The ECG in patients with breathlessness -- The effect of other conditions on the ECG -- The ECG in pacemakers, defibrillators and electrophysiology/ David Adlam -- Conclusions : four steps to making the most of the ECG
  • Section 1: The ECG in Prehospital Patient Care. Clinical Applications of the Electrocardiogram (ECG) / Robert C Schutt, William J Brady, Steven H Mitchell -- Clinical Impact of the Electrocardiogram (ECG) / Robert C Schutt, William J Brady, Steven H Mitchell -- Interpretation of the Electrocardiogram : Single-, Multi-, and 12-Lead Analysis / Robert C Reiser, Robert C Schutt, William J Brady -- Variants of the Normal, Lead Misplacement, and Electrocardiographic Artifact Encountered in Clinical Practice / Robert C Reiser, Robert C Schutt, William J Brady -- Section 2: Cardiac Rhythms and Cardiac Dysrhythmias. Cardiac Rhythms with Normal Rates / Korin B Hudson, William J Brady -- Narrow QRS Complex Tachycardia / Courtney B Saunders, Jeffrey D Ferguson -- Wide QRS Complex Tachycardia / Michael Levy, Francis X Nolan -- Bradycardia / Korin B Hudson, J Aidan Boswick, William J Brady -- Atrioventricular Conduction Block / Steven H Mitchell, Korin B Hudson, William J Brady -- Intraventricular Conduction Block: Bundle Branch Block and Other Conduction Abnormalities / Steven H Mitchell, Richard B Utarnachitt, William J Brady -- Atrial and Ventricular Ectopic Beats / Jeffrey D Ferguson, Michael Levy, J Aidan Boswick, William J Brady -- Section 3: Acute Coronary Syndrome and the 12-Lead ECG. Ischemic Heart Disease: Anatomic and Physiologic Considerations / Peter Pollak, Peter Monteleone, Kelly Williamson, David Carlberg, William J Brady -- Historical Development of the Prehospital Electrocardiogram (ECG) / Erik Iszkula, David Carlberg, William J Brady -- Electrocardiographic Findings in Acute Coronary Syndrome / Peter Monteleone, Peter Pollak, David Carlberg, William J Brady -- Section 4: Special Populations, High-Risk Presentation Scenarios, and Advanced Electrocardiographic Techniques. The Electrocardiogram in the Pediatric Patient / Robert Rutherford, Robin Naples, William J Brady -- The Electrocardiogram in the Poisoned Patient / Steven H Mitchell, Christopher P Holstege, William J Brady -- The Electrocardiogram in Hyperkalemia / Steven H Mitchell, William J Brady -- Life-Threatening Electrocardiographic Patterns / Steven H Mitchell, Richard B Utarnachitt, William J Brady -- The Electrocardiogram in Patients with Implanted Devices / Amita Sudhir, William J Brady -- Electrocardiographic Tools in Prehospital Care / Robin Naples, Alvin Wang, William J Brady -- Wolff-Parkinson-White Syndrome / William J Brady -- Cardiac Arrest Rhythms / Amita Sudhir, William J Brady -- Section 5: Electrocardiographic Differential Diagnosis of Common ECG Presentations. Electrocardiographic Differential Diagnosis of Narrow Complex Tachycardia / Megan Starling, William J Brady -- Electrocardiographic Differential Diagnosis of Wide Complex Tachycardia / Amita Sudhir, William J Brady -- Electrocardiographic Differential Diagnosis of Bradyarrhythmia / Megan Starling, William J Brady -- Electrocardiographic Differential Diagnosis of ST Segment Elevation / Megan Starling, William J Brady -- Electrocardiographic Differential Diagnosis of ST Segment Depression / Amita Sudhir, William J Brady -- Electrocardiographic Differential Diagnosis of T Wave Abnormalities: The Prominent T Wave and T Wave Inversions / Amita Sudhir, William J Brady.
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    What the ECG is about -- Conduction and its problems -- The rhythm of the heart -- Abnormalities of P waves, QRS complexes and T waves -- How to use the ECG -- Reminders -- Now test yourself.
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    Anatomy and physiology of the heart -- Electrophysiology -- Waveforms, intervals, segments, and complexes -- Cardiac monitors -- Analyzing a rhythm strip -- Sinus arrhythmias -- Atrial arrhythmias -- AV junctional arrhythmias and AV blocks -- Ventricular arrhythmias and bundle-branch block -- Pacemakers -- Posttest.
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  • Echinodermata 2005
    Are echinoderms of interest to biotechnology? / C. Petzelt -- Cell adhesion and communication : a lesson from echinoderm embryos for the exploitation of new therapeutic tools / F. Zito ... [et al.] -- Cell signalling during sea urchin development : a model for assessing toxicity of environmnetal contaminants / C. Angelini ... [et al.] -- Echinoderm reactive oxygen species (ROS) production measured by peroxidase, luminol-enhanced chemiluminescence (PLCL) as an immunotoxicological tool / G. Coteur, B. Danis, P. Dubois -- Monitoring chemical and physical stress using sea urchin immune cells / V. Matranga ... [et al.] -- DNA damage and developmental defects after exposure to UV and heavy metals in sea urchin cells and embryos compared to other invertebrates / H.C. Schröder ... [et al.] -- Echinoderms : their culture and bioactive compounds / M.S. Kelly -- Regenerative response and endocrine disrupters in crinoid echinoderms : an old experimental model, a new ecotoxicological test / M.D. Candia Carnevali -- Echinoderm adhesive secretions : from experimental characterization to biotechnological applications / P. Flammang, R. Santos, D. Haesaerts -- Mutable collagenous tissue : overview and biotechnological perspective / I.C. Wilkie -- Bioresources from echinoderms / Y. Yokota.
  • Also available: Print – 2006
    How to obtain a good echocardiography examination: ultrasound physics, technique, and medical knowledge -- Transthoracic echocardiography: M-mode, two-dimensional, and three-dimensional -- Transesophageal and intracardiac echocardiography / Jae K. Oh ... [et al.] -- Doppler echocardiography and color flow imaging: comprehensive noninvasive hemodynamic assessment -- Tissue doppler imaging, strain imaging, and dyssynchrony assessment / Brian D. Powell ... [et al.] -- Contrast echocardiography -- Assessment of systolic function and quantification of cardiac chambers -- Assessment of diastolic function and diastolic heart failure -- Pulmonary hypertension and pulmonary vein stenosis -- Coronary artery disease and acute myocardial infarction -- Stress echocardiography -- Valvular heart disease -- Prosthetic valve evaluation -- Infective endocarditis -- Cardiomyopathies -- Cardiac diseases due to systemic illness, genetics, medication, or infection -- Pericardial diseases -- Tumors and masses -- Diseases of the aorta -- Echocardiography in congenital heart disease: an overview / Frank Cetta, Jr., James B. Seward, Patrick W. O'Leary -- Intraoperative echocardiography / Roger L. Click, Jae K. Oh -- Vascular imaging and tonometry / A. Rauoof Malik, Iftikhar J. Kullo -- Goal-directed and comprehensive examination.
  • This atlas of echocardiography presents more than 100 cases of adult congenital heart disease, from diagnosis to treatment follow-up. The coverage is broad, encompassing atrial and ventricular septal defects, patent ductus arteriosus, cyanotic adult congenital heart disease, and numerous other anomalies, as well as findings on fetal echocardiography. For each disease, all echocardiographic images and views which proved of diagnostic value are arranged sequentially, with inclusion of transesophageal echocardiographic images whenever appropriate. Additional pertinent information is provided relating to diagnosis and treatment, and key teaching points are highlighted. The superb quality of the illustrations and the range of cases considered (including many rare ones) ensure that this atlas will be of great value for cardiology residents and fellows and highly relevant to day-to-day practice.
  • Echocardiography has become an invaluable tool in intensive care medicine because of its ease of use and instantaneous provision of precise information on cardiovascular functional anatomy at the bedside. This book contains all the information that readers will require in order to perform echocardiography and lung ultrasound, and to interpret the findings correctly, permitting optimal guidance of the hemodynamic management of unstable patients. Furthermore, lung ultrasound is dealt with for both diagnosis and treatment of respiratory failure requiring mechanical ventilation. After an introductory chapter on the essential physics of ultrasonography, standard echocardiographic examination via both the transthoracic and the transesophageal approach is described. In the third section, the functional anatomy of all normal and pathologic thoracic structures as observed on echocardiography is presented in detail. A wide range of basic and advanced applications of echocardiography in the emergency and intensive care setting are then described. A final supplementary section considers further applications of ultrasound in the intensive care unit, such as ultrasound-guided vein cannulation, Doppler renal evaluation, transcranial Doppler, and lung and pleural ultrasound. This superbly illustrated book has been specifically designed to meet the needs of all intensivists, emergency physicians, and anesthesiologists who intend to use ultrasound extensively to guide optimal management of the critically ill.
  • A volume in the exciting new Practical Echocardiography Series edited by Dr. Catherine M. Otto - provides practical how-to-do-it guidance on echocardiography for an ever-growing number of pediatric and adult congenital heart disease patients. Drs. Mark B. Lewin and Karen Stout offer you definitive, expert instruction with a highly visual, case-based approach that facilitates understanding and equips you to accurately acquire and interpret images while avoiding pitfalls. Master challenging and advanced techniques including 3-D echocardiography and transesophageal echocardiography through a practical, step-by-step format that provides a practical approach to data acquisition and analysis, technical details, pitfalls, and case examples. Expand your knowledge and apply the latest findings on congenital cardiovascular abnormalities and adult congenital heart disease. Reference the information you need quickly thanks to easy-to-follow, templated chapters, with an abundance of figures and tables that facilitate visual learning. Master echocardiography techniques for pediatric and adult patients with Congenital Heart Disease.
  • Distinguishing systolic vs. diastolic heart failure : a practical approach by echocardiography / Tasneem Z. Naqvi -- Evaluation of the patient with systolic heart failure / Maurice Enriquez Sarano and Sorin Pislaru -- Echo parameters important for clinical decision making in HF / Bob McNamara -- Evaluation of the patient with diastolic dysfunction / Ted Abraham, Jacob Abraham, and Kristian Eskesen -- Hypertensive heart failure / Richard Devereux and Fay Lin -- Heart failure due to coronary disease / Martin St. John Sutton, Yan Wang, and Ted Plappert -- Hypertrophic cardiomyopathy / Anna Woo and Sean Jedrzkiewicz -- Role of echocardiography in patients treated with cardiotoxic drugs / Bonnie Ky -- Assessment of treatment for systolic CHF / Judy Hung -- Echocardiography in the patient with right heart failure / Susan Wiegers and Anjali Tiku Owens -- Heart failure due to congenital heart disease / Meryl Cohen -- Echocardiographic evaluation of ventricular support devices / James Kirkpatrick -- The role of echocardiography for OHT / Amresh Raina.
  • This book provides a comprehensive account of the role of echocardiography in patients with mitral valve disease. The normal echocardiographic anatomy of the mitral valve is first presented, and the applications of echocardiography in mitral valve disease are then covered in detail by experts from different subspecialties in cardiology. Topics include etiology, pathophysiology, diagnosis, assessment of severity, and role of echocardiography in percutaneous and surgical techniques. The highly readable text is supported by a wealth of color images obtained with 3D echocardiography, currently the gold standard for the evaluation of mitral valve disease. The interdisciplinary approach used in describing the diagnostic and therapeutic applications will make this book useful for the clinical cardiologist as well as the echocardiographer. It will allow cardiologists to advance their knowledge in the field and will serve as an excellent updating tool for professionals engaged in echocardiography and cardiac diagnostic imaging.
  • Ultrasounds, a much reflected system -- The doctor in front of the machine -- The doctor and the machine in front of the patient -- The doctor, the machine, and the patient in front of the screen -- Learning methods -- Self-training procedure.
  • Also available: Print – 1885.
  • Extracorporeal membrane oxygenation (ECMO) has been in clinical use for some 40 years, but it is only in the past decade that its application in the treatment of life-threatening circulatory and respiratory failure has truly flourished. This book presents a comprehensive overview of both pathophysiological and practical aspects of circulatory and respiratory extracorporeal support. The basics of ECMO, including its history, the "ECMO team", cannulation, materials, and blood-surface interactions, are first discussed. The various indications for and particular characteristics of circulatory and respiratory extracorporeal life support are then described in detail in the main part of the book. Patient care during ECMO and monitoring of the ECMO patient are also carefully covered, with explanation of the management of technical and clinical complications and transport-related problems. Further topics include long-term therapy options beyond ECMO, such as ventricular assist devices and transplants, outcome, the new frontiers of ECMO for organ procurement and future challenges. The authors are well-known experts in the field whose authoritative contributions and attention to practical aspects will be invaluable for novices and experienced practitioners alike.
  • Understanding the causes and consequences of biological diversity remains the unifying goal of ecology and evolutionary. One promising avenue to understand the causes and consequences of genetic diversity within populations is to consider correlations between that genetic diversity and species diversity of the community in which it resides. Both genetic and species diversity can respond to locality characteristics, or each level can influence and be influenced by the other. First, I investigate how area connectivity and gene flow affects the population genetic diversity patterns in the California vole (Microtus californicus). I show that migration across the landscape produces an identical genetic patterns at the local and regional spatial scales in this small mammal (Chapter 1). Next, I explored two ways in which genetic and species diversity influence each other. In one approach, I examine the effects of a species-rich competitor community on the genotypic diversity of a focal community when genetic diversity allows for differential strength of competition with different species. Using computer simulations, I show that species diversity of competitors can act as an important promoter of genotypic diversity within species (Chapter 2). Next, moving to a riparian community in northern Utah, I demonstrate that the genetic diversity of a foundation tree correlates positively with the species diversity of understory plants, including forbs, grasses, and vines (Chapter 3). Finally, I show that both genetic diversity and species richness across the globe show a similar pattern: genetic markers in over 70 vertebrate species show a significant trend of higher diversity at low latitudes than at higher latitudes (Chapter 4). By taking a broad approach to understanding the causes and consequences of intraspecific genetic diversity, with a particular focus on links to species diversity patterns, my dissertation finds general principles that operate across systems. The two levels of diversity can influence each other by creating spatially-varied selection regimes, but gene flow and mutation are two processes operating on the genetic level whose power to scale up to influence species-level patterns is highly contextual.
  • Also available: Print – 2014
    "Researchers in the field of ecological genomics aim to determine how a genome or a population of genomes interacts with its environment across ecological and evolutionary timescales. Ecological genomics is trans-disciplinary by nature. Ecologists have turned to genomics to be able to elucidate the mechanistic bases of the biodiversity their research tries to understand. Genomicists have turned to ecology in order to better explain the functional cellular and molecular variation they observed in their model organisms. Ecological genomics covers 3 fields of research that have most benefited from the recent technological and conceptual developments in the field of ecological genomics: the study of life-history evolution and its impact of genome architectures; the study of the genomic bases of phenotypic plasticity and the study of the genomic bases of adaptation and speciation"-- Publisher's description.
  • Disturbance, survival, and succession : understanding ecological responses to the 1980 eruption of Mount St. Helens / Virginia H. Dale, Frederick J. Swanson and Charles M. Crisafulli -- Geological and ecological settings of Mount St. Helens before May 18, 1980 / Frederick J. Swanson, Charles M. Crisafulli and David K. Yamaguchi -- Physical events, environments, and geological-ecological interactions at Mount St. Helens : March 1980-2004 / Frederick J. Swanson and Jon J. Major -- Plant responses in forests of the tephra-fall zone / Joseph A. Antos and Donald B. Zobel -- Plant succession on the Mount St. Helens debris-avalanche deposit / Virginia H. Dale ... [et al.] -- Geomorphic change and vegetation development on the Muddy River mudflow deposit / Peter M. Frenzen ... [et al.] -- Proximity, microsites, and biotic interactions during early succession / Roger del Moral, David M. Wood and Jonathan H. Titus -- Remote sensing of vegetation responses during the first 20 years following the 1980 eruption of Mount St. Helens : a spatially and temporally stratified analysis / Rick Lawrence -- Arthropods as pioneers in the regeneration of life on the pyroclastic-flow deposits of Mount St. Helens / John S. Edwards and Patrick M. Sugg -- Posteruption arthropod succession on the Mount St. Helens volcano : the ground-dwelling beetle fauna (Coleoptera) / Robert R. Parmenter ... [et al.] -- Causes and consequences of herbivory on prairie lupine (Lupinus lepidus) in early primary succession / John G. Bishop ... [et al.] -- Responses of fish to the 1980 eruption of Mount St. Helens / Peter A. Bisson ... [et al.] -- Amphibian responses to the 1980 eruption of Mount St. Helens / Charles M. Crisafulli ... [et al.] -- Small-mammal survival and colonization on the Mount St. Helens volcano : 1980-2002 / Charles M. Crisafulli, James A. MacMahon and Robert R. Parmenter -- Mycorrhizae and Mount St. Helens : story of a symbiosis / Michael F. Allen ... [et al.] -- Patterns of decomposition and nutrient cycling across a volcanic disturbance gradient : a case study using rodent carcasses / Robert R. Parmenter -- Lupine effects on soil development and function during early primary succession at Mount St. Helens / Jonathan J. Halvorson, Jeffrey L. Smith and Ann C. Kennedy -- Response and recovery of lakes / Clifford N. Dahm ... [et al.] -- Ecological perspectives on management of the Mount St. Helens landscape / Virginia H. Dale, Frederick J. Swanson and Charles M. Crisafulli -- Overview of ecological responses to the eruption of Mount St. Helens : 1980-2005 / Charles M. Crisafulli, Frederick J. Swanson and Virginia H. Dale.
  • Ecological studies v. 1-, 1970-
  • Recent work on the human microbiome represents the essence of community ecology: "What makes assemblages of species more or less similar to each other at different places and times?" (Vellend 2010; Anderson et al. 2011). The complex microbial communities of the human subgingival crevice are particularly relevant since multiple, spatially distinct but ecologically similar sites are found in a single subject. Healthy sites and sites affected by periodontitis (gum disease) can coexist in the same mouth simultaneously; periodontal disease may reflect community processes since it is thought to have a polymicrobial etiology rather than a single species etiology in the tradition of Koch's postulates. Subgingival communities therefore provide a unique, clinically relevant context to apply ecological concepts. The goal of this work was to advance our ecological understanding of the human subgingival microbiota, drawing on two fields of ecological research: biogeography and the stability of complex communities. The first half of this work explored oral biogeography and treating subgingival sites as isolated, island-like patches of similar habitat distributed within a mouth. A survey of twenty-three to thirty subgingival sites per mouth within five periodontally healthy subjects uncovered non-random, spatially relevant patterns of community distributions. Specifically, a left-right symmetric pattern of community similarity and a positive correlation between physical distance between sites and the dissimilarity of their respective communities were observed. However, these patterns were only discernable among deeply sequenced communities. Additional applications of co-occurrence analysis and neutral theory models to the data indicated that both competitive interactions and stochastic, demographic processes influence distributions of subgingival taxa. The second half of this work assessed the temporal stability of health and periodontitis-associated subgingival and salivary microbial communities before and after a single disturbance event of professional teeth cleaning. Communities were surveyed in 8 subjects (4 healthy, 4 with moderate chronic periodontitis), at 4 sites per subject, and at four sampling times ranging from 2 weeks to 1 day before the cleaning to assess baseline spatial and temporal variation. Samples collected at seven time points ranging from 1 hour to 3 months after the cleaning were also examined in order to monitor the compositional response to the perturbation. The results of this work demonstrated that healthy and periodontitis-associated subgingival communities are resilient to a teeth-cleaning perturbation, but the displacement of community composition immediately after cleaning was greater in periodontitis than in health. Periodontitis-associated subgingival communities more closely resembled a health-like composition as they recovered from the cleaning, although this change was transient. Salivary communities were also shown to be resilient to a teeth cleaning perturbation, but the impact of the cleaning on community composition is less pronounced in saliva. The results further suggest that post-cleaning residual subgingival communities contribute more to subgingival recolonization than salivary communities. The results of this work generated testable hypotheses about the ecological mechanisms governing observed spatial and temporal patterns. I hope these findings will contribute to the development of novel, ecologically informed approaches to the clinical treatment of the subgingival environment.
  • Human immunodeficiency virus (HIV) is a significant problem worldwide as well as in the United States (US), despite ongoing efforts to limit HIV transmission. In the US, men who have sex with men (MSM) account for over half of new HIV infections every year, and thus are an important group to consider for HIV interventions. Both prevention and treatment options are available to combat HIV transmission, but decision makers must prioritize among the available disease control strategies. Mathematical modeling frameworks can be used to assess the value and efficiency of various disease control measures and help inform resource allocation decisions. This dissertation describes research on economic analysis of HIV prevention and treatment portfolios, primarily for MSM in the US. We develop two independent mathematical modeling frameworks, both intended to assist decision makers with minimizing HIV transmission in the most cost-effective manner. First, in Chapter 2, we present a dynamic compartmental model of the HIV epidemic that we built and instantiated for MSM in the US. This model can be used to assess the effectiveness and cost-effectiveness of prevention and treatment programs for MSM. In particular, in Chapter 3 we examine testing for and treating acute HIV infection, and in Chapter 4 we examine preexposure prophylaxis for HIV prevention. We find that symptom-based testing for acute HIV infection is cost-effective for MSM in the US, but incorporating testing for acute infection into the standard HIV screening protocol is not. For preexposure prophylaxis, we find that it is not cost-effective for the general MSM population, but it provides good value in high-risk MSM. In Chapter 5, we present a resource allocation framework for determining the optimal mix of HIV treatment and prevention programs, given a fixed budget. We develop methods of linearly estimating health benefits and costs that account for epidemic effects of reducing disease transmission. We illustrate our model with the examples of preexposure prophylaxis and community-based education compared with antiretroviral therapy for MSM in the US. We show both analytically and with the examples that HIV budgets are often best spent on the program that offers the greatest "bang for the buck.".
  • The magnitude of the problem of malnutrition in Europe / Kondrup, J. -- Malnutrition in North America : where have we been? Where are we going? / Jensen, G. -- The economics of malnutrition / Elia, M. -- The need for consistent criteria for identifying malnutrition / Hoffer, J. -- Enteral nutrition reimbursement : the rationale for the policy : the US perspective / Parver, A.K. -- Enteral nutrition reimbursement : the rationale for the policy : the German perspective / Pahne, N. -- Food modification versus oral liquid nutrition supplementation / Silver, H. -- Cost-effectiveness analysis and health policy / Torgerson, D. -- Implementing nutritional standards : the Scottish experience / McKinlay, A. -- Innovative models for clinical nutrition and financing / Van Emelen, J. -- ENHA : what is it and what does it do? Reimbursement is not the solution / De Man, F. -- Brief history of parenteral and enteral nutrition in the hospital in the USA / Bistrian, B. -- What went right? The story of US Medicare medical nutrition therapy / Patrick, S.
  • The book presents a basic introduction to epidemiology from the perspective of economics, using economic modeling to better understand and describe how infectious disease spreads. Three main elements are introduced: epidemiology, social network analysis, and the economics needed to model the behavior of individuals in the presence of infectious disease. The book aims to provide a starting point for discussion between medical professionals, social scientists and public health officials, the three groups interested in the spread of disease.
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    "In response to the growing concern about equity issues and their implications for overall development, WHO established the Commission on Social Determinants of Health (CSDH) in 2005, which focused on the "social justice" or human rights arguments for health investments. CSDH investigated the factors involved in the so-called "social gradient in health", which refers to the large observable differences in health outcomes within and between countries that are determined by avoidable inequalities in the access to resources and power. CSDH aimed to further investigate the causes of health inequities, with a deliberate detachment from economic considerations, and provide advice on how to tackle them effectively. CSDH also reviewed evidence for action on a wider scope of interventions than CMH, many of which require intersectoral collaboration or advocacy. With CMH and CSDH having adopted different but perhaps complementary standpoints, it soon became clear that greater synergies had to be forged between the two. This WHO resource book on the economics of social determinants of health and health inequalities seeks to begin to build a bridge between the two approaches by explaining, illustrating and discussing the economic arguments that could (and could not) be put forth to support the case for investing in the social determinants of health on average and in the reduction in socially determined health inequalities. The resource book has two main objectives: -- to provide an overview and introduction into how economists would approach the assessment of the economic motivation to invest in the social determinants of health and socially determined health inequities, including what the major challenges are in this assessment; -- to illustrate the extent to which an economic argument can be made in favour of investment in three major social determinants of health areas: education, social protection, and urban development and infrastructure."--WHO website
  • EcoSal 2004
    Am Soc Microbiol
    An archive of the entire corpus of knowledge on the enteric bacterial cell, comprised of several hundred modules of information and interpretation, including the genome database.
  • Exploring the linkages between ecosystems and human health -- Evolution towards an ecosystem approach to public health -- Ecosystem approaches to human health: key concepts and principles -- Community-based participatory research for ecohealth -- The process of conducting an ecohealth research project: a participatory action research approach -- Applying an ecosystem approach to community health research in Ghana: a case study -- Planning for a healthy community: a case study: phase II -- Challenges and ethical dilemmas in conducting participatory ecohealth research -- Ecosystem approaches to indigenous health -- Policy frameworks on health and environmental linkages -- Applying critical theory to environmental and health issues -- Examining environmental problems from a critical perspective -- Examining public health concerns from a critical perspective -- Towards a critical approach to ecohealth research and practice.
  • "The third edition of a bestseller, this book describes how chemical toxins and biological hazards impact the environment and people. Addressing how pollutants can alter the environment by contributing to global climate change, the author explores a broad range of environmental and health aspects of chemical and biological hazards. He includes numerous examples of the intimate relationship between ecosystem health and human health and emphasizes the need to consider this relationship whenever human activities are likely to have a significant environmental impact"-- Provided by publisher.
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    Why do ecosystems matter to human health? -- How have ecosystems changed and what are the health implications? -- What actions are required to address the health consequences of ecosystem change? -- How can priorities be established for actions to address the health consequences of ecosystem change? -- What are the policy implications of the most robust findings and key uncertainties?
  • I. Hierarchical ecotoxicology. The hierarchical science of ecotoxicology -- II. Organismal ecotoxicology. The organismal ecotoxicology context -- Biochemistry of toxicants -- Cells and tissues -- Organs and organ systems -- Physiology -- Bioaccumulation -- Models of bioaccumulation and bioavailability -- Lethal effects -- Sublethal effects -- Conclusion -- III. Population ecotoxicology. The population ecotoxicology context -- Epidemiology : the study of disease in populations -- Toxicants and simple population models -- Toxicants and population demographics -- Phenogenetics of exposed populations -- Population genetics : damage and stochastic dynamics of the germ line -- Population genetics : natural selection -- Conclusion -- IV. Community ecotoxicology. Introduction to community ecotoxicology -- Biotic and abiotic factors that regulate communities -- Biomonitoring and the responses of communities to contaminants -- Experimental approaches in community ecology and ecotoxicology -- Application of multimetric and multivariate approaches in community ecotoxicology -- Disturbance ecology and the responses of communities to contaminants -- Community responses to global and atmospheric stressors -- Effects of contaminants on trophic structure and food webs -- Conclusions -- V. Ecosystem ecotoxicology. Introduction to ecosystem ecology and ecotoxicology -- Overview of ecosystem processes -- Descriptive approaches for assessing ecosystem responses to contaminants -- The use of microcosms, mMesocosms, and field experiments to assess ecosystem responses to contaminants and other stressors -- Patterns and processes : the relationship between species diversity and ecosystem function -- Fate and transport of contaminants in ecosystems -- Effects of global atmospheric stressors on ecosystem processes -- VI. Ecotoxicology : a comprehensive treatment--conclusion -- Conclusion.
  • "ENOX Proteins" documents a unique family of cell surface proteins which are the exclusive discovery (subsequently confirmed by others) of the authors, their students and their colleagues. An ENOX-based mechanism is provided for how cells increase in size that is both unique and applicable not only to cancer and cancer therapy but also to production agriculture and biomass increase. The role of ENOX proteins in biological time-keeping is described along with evidence for oscillations in the ratios of electron spin pairs defining ortho and para water states that form highly coordinated populations of coherent water of interest to physicists as the underlying mechanism. The age-related NADH oxidases that appear around age 30 and increase steadily thereafter with potentially causal involvements in atherogenesis and skin aging have been identified as five members of the TM-9 protein superfamily of all with different chromosomal locations. The arNOX proteins initially are membrane anchored but functionally-active N-terminal fragments that are shed into body fluids. Except for critical functional motifs, all of the ENOX protein family members have distinct protein sequences and chromosomal origins. A fourth member of the ENOX protein family occurs in plants as the primary target for both natural and synthetic growth hormone (auxin)-stimulated rapid cell enlargement. Despite masquerading as intractable and difficult to clone and characterize, ENOX proteins offer remarkable opportunities for research, commercial development and outside confirmation of new paradigms to help explain complex biological processes.
  • Comprised exclusively of clinical cases covering ectopic pregnancy, this concise, practical casebook will provide clinicians in reproductive medicine and obstetrics/gynecology with the best real-world strategies to properly diagnose and treat the various forms of the condition they may encounter. Each chapter is a case that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and management techniques used to treat it, as well as the case outcome and clinical pearls and pitfalls. Cases included illustrate different management strategies ? from treatment with methotrexate to surgical interventions ? as well as types of ectopic pregnancy, such as ovarian, interstitial, heterotopic and abdominal forms, among others. Pragmatic and reader-friendly, Ectopic Pregnancy: A Clinical Casebook will be an excellent resource for reproductive medicine specialists, obstetricians and gynecologists, and family and emergency medicine physicians alike.
  • Introduction -- When does a human being become a person? -- All human beings are persons -- How is the dignity of the person as agent recognized? Distinguishing intention from foresight -- An ethical assessment of Bush's guidelines for stem cell research -- Moral absolutism and ectopic pregnancy -- Could artificial wombs end the abortion debate? -- Solomon's dilemma: should conjointed twins Jodie and Mary have been separated? -- Capital punishment and the Catholic tradition: contradiction, circumstantial application, or development of doctrine?
  • v. 1. Fruits -- v. 2. Fruits -- v. 3. Fruits -- v. 4. Fruits -- v. 5. Fruits -- v. 6. Fruits -- v. 7. Flowers -- v. 8. Flowers
  • Also available: Print – 2010
    Based on a study of physician education by the Carnegie Foundation for the Advancement of Teaching. Calls for a major overhaul of the present approach to preparing doctors for their careers. The text addresses issues for the future of the field and takes a comprehensive look at the most pressing concerns in physician education today.-- excerpted from publisher notes.
  • Also available: Print – 2015
    1. Introduction -- 2. Characterizing physicians' information needs at the point of care -- 3. Access of primary and secondary literature by health personnel in an academic health center : implications for open access -- 4. Evidence-based medicine training in undergraduate medical education : a review and critique of the literature published 2006-2011 -- 5. Challenges to learning evidence-based medicine and education approaches to meet them : a qualitative study of selected EBM curricula in North American medical schools -- 6. Designing evidence-based medicine training to optimize transfer of skills from the classroom to clinical practice : apply the Four Component Instructional Design Model -- 7. Discussion.
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    Health care from the inside out : bringing the self of the healer into the practice of medicine : an interview with Parker J. Palmer / Marcy Jackson -- From freedom to learn to freedom to innovate : the Harvard Macy Institute story / Elizabeth J. Armstrong with Sylvia Barsion -- Facilitating the effectiveness of medical teachers : improving teaching through faculty development / Kelley M. Skeff, Georgette A. Stratos -- Education of a teacher / William T. Branch Jr. -- Influencing the culture of educational assessment in academic health science centers / Eric Holmboe, William Iobst -- A quality improvement management model for curriculum evaluation and integration / Thomas R. Viggiano -- The dissemination of relationship-centered care approaches to enhance the informal curriculum of academic health science centers / Ann H. Cottingham [and others] -- Partners in global health medical education : learner-centered curriculum in resource-poor environments / Paul O. Ayuo, [et al.] -- An academic health science center's journey toward teaching and delivering patient-centered care / Dale Smith -- The power of doing meaningful work together / Shirley M. Moore -- Reforming medical education : confessions of a battered humanist / DeWitt C. Baldwin Jr. -- Concluding reflections on creating enduring change / Linda A. Headrick, Ann H. Cottingham, Debra K. Litzelman.
  • Contains a database of approximately 70,000 reactions and 4000 of the most frequently consulted reagents. Fully searchable by structure and sub-structure, reagent, reaction type, experimental conditions, and keyword. Also includes a searchable interface: Acronym finder (an interface for Scientific and technical acronyms, symbols, and abbreviations).
  • Effective Java. 2nd ed. 2008
    ProQuest Safari
    Introduction -- Creating and destroying objects -- Methods common to all objects -- Classes and interfaces -- Generics -- Enums and annotations -- Methods -- General programming -- Exceptions -- Concurrency -- Serialization.
  • Understanding migraine and pregnancy -- Safety rating systems for drugs used in pregnancy and lactation -- Non-pharmacological headache treatments -- Acute treatment options for the pregnant headache patient -- Acute treatment options for the lactating headache patient -- Preventive treatment options for the pregnant headache patient -- Preventive treatment options for the lactating headache patient -- Urgent care/emergency treatment of the acute, severe headache in pregnant and lactating patients -- Work-up for headache during pregnancy and lactation -- Patient headache resources.
  • This book explains how training in arthroscopic skills is best carried out in order to keep up to date with advances in arthroscopy, meet the ever-increasing demand for high-quality care, and respond to changes in available training time. State of the art developments regarding tools, performance monitoring, and learning strategies are presented, and practical guidelines provided for direct implementation in daily clinical practice. The coverage of simulation-based training ranges from the use of wet labs and box trainers through to sophisticated virtual reality simulators. Subsequent sections on objective performance tracking of training outside and in the operating room cover a variety of key aspects, including psychomotor learning, the adequacy of performance measures, evidence-based thresholds, preclinical training strategies, the role of global rating scales, and video tools. As a result of the success of arthroscopy, its role in the orthopaedic armamentarium is continuously increasing and ever more complex surgeries are being performed arthroscopically. Effective training in arthroscopy is essential to good outcomes. The guidance provided in this book by acknowledged experts in the field will assist in improving the efficiency and effectiveness of arthroscopic training and in enhancing patient safety.
  • Print Material
  • Rupture of the anterior cruciate ligament (ACL) is one of the most common injuries to the knee. Unfortunately, individuals who experience this injury are likely to develop osteoarthritis of the knee much earlier than would be expected due to the normal ageing process, and this remains true even after surgical reconstruction of the ligament. Research has suggested that a major contributing factor to the development of premature osteoarthritis is altered knee mechanics which change the loading conditions of the cartilage in the joint. Furthermore, it has been shown that altered knee mechanics are present following rupture of the ACL and persist after reconstruction surgery. Despite initial reports, there still remains a need for a comprehensive understanding of both altered knee mechanics in both ACL deficient and ACL reconstructed knees as well as changes in cartilage morphology following ACL injury. Therefore, the goal of this dissertation is to address the question of the relationship between certain changes in knee mechanics and cartilage morphology as they relate to the development of osteoarthritis following both ACL injury and reconstruction. The first study presented involves an analysis of the knee mechanics in individuals with unilateral ACL deficiencies. This group was important in that they were free of knee pain and had no sign of osteoarthritis on MRI over a time frame that ranged up to three decades from injury. This provided a unique opportunity to explore the potential for a protective functional adaption. The results of this study suggest that alteration in knee mechanics may act as a protective mechanism against osteoarthritis development since when subjects were separated into "Short Term" and "Long Term", based upon the time from injury, only those in the "Long Term" group demonstrated a relationship between the external knee flexion moment, which is representative of the interaction between quadriceps and hamstrings muscle to control rotation and translation during walking. This is indicative of an adaptive control mechanism present in some subjects who were able to last many years after the injury without reconstruction surgery. These results suggest the potential for new methods for rehabilitation following ACL injury. The second study presented involves an analysis of the knee mechanics of individuals with unilateral ACL reconstructions during gait, stair ascent, and stair descent at two years from surgery. The results demonstrate a reduction in the external joint moments of ACL reconstructed knees and an increase in the joint moments of uninjured contralateral knees during each activity compared to healthy controls. This suggests two things: 1.) compensation for residual muscle weakness in the affected limb is needed by the contralateral knee during ambulation and 2.) a decrease in daily joint loading in ACL reconstructed knees and an increase in joint loading in contralateral knees. Decreased loading of the ACL reconstructed knee may seem counterintuitive to what was expected in patients who will likely develop premature osteoarthritis in this knee. However, this finding is consistent with the suggestion that changes in joint kinematics and even decreased joint loading following the injury may contribute to the initial cartilage breakdown. Note: Taken together the results of study 1 and 2 suggest that the interaction between muscle function and kinematics should be further considered in the development of knee OA in this population. The third and final study involves articular cartilage morphology analysis of individuals with unilateral ACL reconstructions at two and four years from surgery. The results illustrate differences between cartilage thickness of ACL reconstructed and healthy contralateral knees at both times of testing. The findings show significantly thinner cartilage in the lateral tibial compartment of ACL reconstructed knees at two years from surgery. These differences became more pronounced at four years from surgery and include the addition of a significantly thicker medial region of the tibia of ACL reconstructed knees compared to healthy contralateral knees. The results indicate that patterns of cartilage thickness change are detectable as early two years following ACL reconstruction, and these patterns become more pronounced at 4 years which suggests cartilage begins a degenerative pathway substantially in advance of clinically detectable OA. This finding is important since it provides a basis for assessing early interventions to reduce the risk of knee OA following ACL injury. This dissertation helps to further the understanding of altered knee mechanics following both ACL rupture and reconstruction. In addition, a possible pattern of OA initiation has been reported. Each of these studies will benefit future studies with the ultimate goal of a complete understanding of OA initiation and development in ACL ruptured and reconstructed knees.
  • Drug use and abuse continues to thrive in contemporary society worldwide and the instance and damage caused by addiction increases along with availability. The Effects of Drug Abuse on the Human Nervous System presents objective, state-of-the-art information on the impact of drug abuse on the human nervous system, with each chapter offering a specific focus on nicotine, alcohol, marijuana, cocaine, methamphetamine, MDMA, sedative-hypnotics, and designer drugs. Other chapters provide a context for drug use, with overviews of use and consequences, epidemiology and risk factors, genetic.
  • Print Material
    Preclinical data relating to estrogen's effects on cognitive performance / Robert B. Gibbs -- The short-lived effects of hormone therapy on cognitive function / Eva Hogervorst -- Clinical data from structural and functional brain imaging on estrogen's effects in the central nervous system / Daniel H.S. Silverman, Cheri L. Geist, and Natalie L. Rasgon -- Clinical data on estrogen's effects on mood / Natalie L. Rasgon, Laurel N. Zappert, and Katherine E. Williams -- Preclinical efforts to develop effective neuroSERMs for the brain / Roberta Diaz Brinton and Liqin Zhao -- Basic and clinical data on the effects of SERMs on cognition / Kristine Yaffe, Pauline M. Maki, and Peter J. Schmidt.
  • The project reported here, sponsored by the American Medical Association (AMA), aimed to describe the effects that alternative health care payment models (i.e., models other than fee-for- service payment) have on physicians and physician practices in the United States. These payment models included capitation, episode-based and bundled payment, shared savings, pay for performance (PFP), and retainer-based practice. Accountable care organizations and medical homes, which are two recently expanding practice and organizational models that are based on one or more of these alternative payment models, were also included. Project findings are intended to help guide efforts by the AMA and other stakeholders to make improvements to current and future alternative payment programs and help physician practices succeed in these new payment models--i.e., to help practices simultaneously improve patient care, preserve or enhance physician professional satisfaction, satisfy multiple external stakeholders, and maintain economic viability as businesses
  • T cells will usually recognize any pathogen that threatens the body, despite the many different and constantly changing forms these pathogens can take. This is accomplished by the enormous diversity of T-cell receptors that are randomly generated during T-cell maturation. There are a number of distinct mechanisms that drive this diversity: one is the recombination of gene segments, (designated V, D, and J), from pools of many possible gene segments. Another is the addition and deletion of nucleotides at the gene segments joints (between the V, D, and J segments). This yields ~10^15 different possible T-cell receptors, which is many times greater that the number of T cells in the periphery of either mice (~10^8) or humans (~10^11). The T-cell receptor is formed from two polypeptide chains, α and β, each derived from separately rearranged gene segments. Each chain is composed of semi-randomly chosen gene segments. We utilized three transgenes, one limiting the α chain and two limiting the β chain. These progressively limited the number available gene segments of 100 Vα's to 1; 50 Jα's to 2; 30 Vβ's to 1; 2Dβ's to 1 and 13 Jβ's to 2. This reduced the number of gene segment combinations from a theoretical 3,900,000 to 4 combinations. The addition and deletion of nucleotides at the gene segment joints is unaffected. In an in vivo CTL killing assay, the mice with these limited T cell repertoires are able to recognize most but not all of the antigenic peptides tested (9 of 11, in the most restricted mice). Their immunity to Listeria monocytogenes was reduced somewhat; but the LD50 of Yersinia pseudotuberculosis was not diminished by limiting T-cell repertoire, and viral load after murine cytomegalovirus infection was similar to wild type. The limited repertoire mice also exhibited less vigorous alloreactive responses to some haplotypes, indicating that alloreactive responses are influenced by V gene segment compatibility with the MHC. We conclude that N and P nucleotide addition is sufficient for the bulk of T-cell immunity, at least in the laboratory setting. Limiting V(D)J gene segment choice, despite eliminating some T-cell specificities, does not have a dramatic effect on T-cell immunity.
  • The development of atherosclerosis, a chronic inflammatory disease of the arteries, can usually be attributed to specific regions of the blood vessel. In the straight segments of an artery, endothelial cells (ECs) align with the unidirectional blood flow which commonly occurs in these simple geometries. The elongated and aligned ECs are generally found to have a healthy, athero-resistant phenotype. In contrast, branches or curved vessel geometries have regions of disturbed flow, characterized by low shear stress and high shear stress gradients. In these regions of complicated flow patterns, ECs are non-aligned and have a cobblestone cellular morphology. The non-aligned ECs elicit biological properties that promote atherosclerosis, as the location of atherosclerotic fatty plaque is often found at these bends, branches, or bifurcations. Therefore, this correlation highly suggests that the morphology and biological function are inextricably linked in ECs. The ability to regulate both EC morphology and motility, with the aim to influence EC biology, might be highly beneficial in the prevention or treatment of vascular disease. In this dissertation, anisotropic matrices of collagen nanofibrils were fabricated with a simple flow processing technique and used to investigate fundamental cell-matrix interactions with ECs. The aligned fibrils were able to regulate both the morphology and biology of ECs, thereby suggesting the nanofibrillar collagen can be a useful tool to maintain vascular homeostasis. The ECs elongated and organized their actin cytoskeleton along the direction of the aligned collagen fibrils, as demonstrated by organized actin, microtubule networks, and focal adhesions. The nanofibrillar collagen also promoted increased cellular migration along the direction of the nanofibrils. The quantification of monocyte adhesion and expression level of adhesion molecules, known testing indicators of atherosclerosis development, suggested the aligned nanofibrils also promoted an athero-resistant phenotype in the ECs. ECs are subject to biophysical cues in vivo, either in the form of surface topography (provided by the basement membrane of the ECM) or the hemodynamic effects of blood flow. The combination of these cues regulate the organization and immunogenicity of ECs and is representative of the in vivo environment. Therefore, we also investigated the endothelial behavior when both types of cues (topography and flow) were simultaneously present. At physiological levels of high shear stress (14-17 dynes/cm2), the matrix-aligned ECs were able to resist reorientation despite shear flow perpendicular to the matrix direction. The anisotropic collagen matrix could preserve the alignment and elongation of ECs as well as promote an athero-resistant phenotype after exposure to antagonistic perpendicular flow. The ability of the anisotropic nanofibrillar collagen to regulate cell morphology and especially EC immunogenicity highlights its potential in the treatment of vascular diseases. Therefore, an aligned conduit of collagen nanofibrils was fabricated to address the need for a small-diameter vascular graft capable of regulating cellular function. The vascular graft was designed to have a mechanical integrity comparable to that of native vessels and was able to regulate EC attachment, morphology, and phenotype. In addition, the aligned collagen grafts could support an anti-thrombogenic surface modification, providing short-term patency in the carotid artery model of Sprague-Dawley rats.
  • Also available: Print – 2012
    Part I. Introduction -- Part II. Sound Detection by Aquatic Animals -- Part III. Sound Production by Aquatic Animals -- Part IV. Physiological Effects of Sounds -- Part V. Anthropogenic Sounds and Behavior -- Part VI. Population Effects -- Part VII. Anthropogenic Sound Sources and Their Measurement -- Part VIII. Science, Regulation and Sound Exposure Criteria -- Part IX. Monitoring, Management and Mitigation -- Part X. Workshops and Concluding Remarks.
  • In the last 100,000 years, humans have been subjected to multiple different evolutionary pressures. Migration events, changing food sources, climate change, and technological advances are some of the ways environmental changes have applied pressure on human populations to undergo change. Recent advances in methods to measure differences in DNA sequences have led to new powerful techniques to measure the effect of evolution on different human populations. Also due to the availability of recent explosion of genomic data, our understanding of genetic basis of human disease has grown significantly. However, our knowledge regarding the effect that recent evolution has had on the genetic susceptibility to disease has grown to a much lesser extent. There is a lack of studies attempting to place the genetic basis of disease in the context of recent evolutionary changes. I describe multiple ways in which recent evolutionary pressures on the human genome can lead to insights to understanding how evolution has impacted complex disease. I show that GWAS (Genome-Wide Association Studies) are particularly well suited to measure the effect of recent evolution in complex disease. I provide methodology to detect positive selection in human disease and are able to ascertain whether recent evolution has disproportionately increased or decreased the risk of inherited disease. In addition, I introduce a method to approximate when and where genetic risk differentiation for specific disease has occurred, starting when humans began migration out of Africa. Environmental changes in the last 10,000 years known to have created novel, diverse, and pervasive pathogens. I provide methodology to find positive selection in communicable disease. I identify populations that have most likely been severely impacted by specific pathogens in recent human history. I develop and apply methods to identify specific genetic variants important to both communicable and inherited disease that have been affected by evolutionary pressures. I find that type 1 diabetes has recently undergone strong positive selection towards increasing genetic risk in European derived populations. In addition type 2 diabetes and pancreatic cancer is associated with migration trajectories and I find genetic risk differentiation exceeding what is expected by genetic drift in a total of 11 complex diseases. Finally, I find evidence of positive selection in many distinct populations within proteins interacting bacillus anthracis and yersinia pestis, which cause anthrax and the bubonic plague, respectively. I have shown how recent evolution can lead to an increased understanding of both inherited and infectious disease.
  • The bryostatins are a family of structurally complex natural products isolated from the marine bryozoan Bugula neritina. Bryostatin 1 is currently being investigated for cancer, Alzheimer's and HIV/AIDS indications. Despite these remarkable activities, research on the bryostatins is hampered by their low natural abundance. Efficient access by total chemical synthesis has been in large part precluded by the bryostatins' structural complexity. This dissertation describes the design, synthesis, and preliminary biological evaluation of functional bryostatin analogs that possess biological activities comparable or superior to the natural product. These fully synthetic analogs were convergently assembled in a uniquely step-economical manner using novel macrocyclization strategies, including macroacetalization and Prins-driven macrocyclization approaches. Bryostatin analogs were identified that possess unique affinities (subnanomolar) and selectivities for protein kinase C (PKC). Synthetic bryostatin analogs also exhibit subnanomolar antileukemic activity in in vitro assays. The convergent total synthesis of bryostatin 9, a highly potent congener of the natural product family, is also described.
  • The heart is an essential heterogeneous organ that depends on strong coupling between electrical, chemical, and mechanical dynamics to properly function as a pump that supplies blood to the rest of the body. Cardiac arrhythmias are common disorders characterized by irregular beating of the heart that lead to serious clinical conditions. It is estimated that approximately 2.2 million adults in the United States are affected by atrial fibrillation, a prevalent arrhythmia. Unfortunately, a clinician often does not have enough information to diagnose a patient's heart condition to determine the optimal treatment procedure. This is an area that computational mechanics can address. While development of mechanical and electrophysiological models of cardiac tissue primarily started in the 1950s, fully-coupled models have only more recently been developed due to factors regarding computational cost, difficulty in quantifying material properties, and difficulty in integrating complex models in a cohesive and efficient manner. Therefore, in order for simulation tools to have impact in the clinical or experimental setting, these tools must be efficient, fast, robust, and accessible. The focus of this thesis is to develop methods of addressing the aforementioned issues and then illustrate how efficient electromechanical finite element models can be developed for the heart such that their use in the clinical and experimental setting can be realized in several examples. In this thesis, a global-local variable splitting formulation borrowed from the field of plasticity is used to address the issues of complex model integration, and to maintain numerical stability at low costs. Through careful examination of classical phenomenological models and detailed biophysical ionic models of the electrophysiology of the heart, almost all models can be reformulated into this global-local splitting framework. The numerical properties of cost-expensive ionic models are briefly analyzed within the context of this framework. Use of implicit-time stepping in tandem with a simple iteration and error tolerance based adaptive time-stepping algorithm allows for reduction of computation time from hours to minutes. Flexibility and modularity of the framework are illustrated through the development of electrical, electro-chemical, electro-chemical-mechanical, and opto-electro-mechanical models of cardiac tissue. The heart is modeled efficiently using custom finite element ventricular cell models for physiological electrical simulations and large deformation excitation-contraction dry-pumping simulations of the heart. The results accurately model the physiological condition of the heart. The flexibility and multiscale nature of the framework is also leveraged in developing novel optical-induced cardiac cell excitation models of new genetically engineered Channelrhodpsin-2 (ChR2) cardiac myocytes. An ionic model was developed for these particular bio-engineered stem cells, calibrated with experimental data from collaborators, and was able to predict the electrical excitation behavior of the cells to a reasonable degree of accuracy. This model was then combined with ionic pacemaker cell models and also with ventricular cell models into respective finite elements to simulate experiments and predict future therapies using ChR2 genetically modified cardiac tissue. The thesis also addresses difficulties relating to identification and characterization of material parameter identification in inhomogeneous cardiac tissue. Metrics for determining smoothness in electrical conduction in tissue cultures were validated with stochastic finite element models of microelectrode array cell conduction experiments. The results indicate that these metrics are useful in characterizing different conduction patterns based on two metrics borrowed from texture analysis. Difficulties in obtaining structural fiber data from clinical images were addressed by developing an algorithmic method for designating approximate physiologically accurate fiber distributions for the heart using only geometrical information obtained from MRI scans of the surfaces of the heart. Poisson interpolation is used and results in a smooth continuous rotating fiber description that matches experimentally obtained fiber directions from MRI scans. The main benefits of this algorithm are its simplicity of implementation, physiologically accuracy, and generality in interpolating fiber distributions. Lastly, the thesis demonstrates possible benefits of GPU computing in order to achieve near-real-time electrical simulations of arrhythmias in the heart. The assembly and solver routines from the finite element code, FEAP from Berkeley, were ported to the GPU using CUDA. Even with a minimally optimized proof-of-concept, the GPU-only finite element code achieves performance comparable to twelve cores using only one GPU. To increase the overall efficiency of the method, current sparse matrix vector multiplication GPU algorithms are analyzed, and possible alternative algorithms are developed specifically with unstructured finite element meshes in mind. Altogether, the different methods developed in this thesis have been shown to be effective in addressing issues related to efficiency, numerical stability, modularity, and flexibility in real computational applications of the heart. Special consideration was taken in designing the different methods to be compatible with one another, such that a majority of the methods could be integrated and the benefits of each method could be leveraged with each other to gain maximum efficiency. While these developed methods can still be improved, the thesis work as a whole serves to demonstrate and highlight future uses for computational models within experimental and clinical settings.
  • The central theme of this work revolves around the genetics of admixed individuals---individuals who derive their ancestry from two or more different ancestral populations.The genomes of admixed individuals exhibit unique properties that make them both fascinating and challenging to study using existing statistical methods. Their uniqueness lies in their block-like structure, a feature that is the direct result of generations of recombination events. An important advance in the field of admixture genetics has been the development of algorithms capable of determining the ancestry of different regions in the admixed genome. As we will illustrate in this work, local ancestry information can readily be harnessed towards the investigation of subcontinental structure, by which we attempt to determine the specific ancestral populations that gave rise to the admixed genomes under study, and whether differences exist in the ancestral makeup of these admixed samples. The latter line of investigation is of particular relevance to genome-wide association studies, which are prone to confounding if structure in a population has not been explicitly corrected for. This work is thus divided into three parts. We first apply some straightforward multivariate statistical methods such as PCA to gain insights into the African ancestry of African Americans. To this end, we introduce a novel method for the study of specific components of admixture in admixed individuals. We then expand on this work to introduce more sophisticated algorithms for the study of admixed genomics. These methods entail the development of an improved method for local ancestry deconvolution, and the implementation of a PCA approach designed to handle large amounts of missing data. We illustrate the power of using these methods in conjunction with one another with the study of two Latino populations. Finally, we describe a novel phasing algorithm designed to incorporate sequencing information into the process of haplotype reconstruction---an important upstream step for many of the analyses described here.
  • We present models and algorithms that can be applied to common problems in analysis of genomic data. These include CNV (Copy Number Variation) detection, local ancestry inference in admixed populations, and haplotype inference in panels of unrelated individuals. Chapter 2 proposes a new algorithm for the Fused Lasso Signal Approximator which was recently been proposed as an alternative to HMM's for CNV detection. Chapter 3 describes new models for local ancestry inference when high density genotype data is available, and our focus is on a higher order Autoregressive Hidden Markov Model (ARHMM). We give solutions to problems that have thus far prevented the use of higher order ARHMM's for this task, and we demonstrate the model on real and simulated data. Finally, in chapter 4 we given an approach for inferring haplotypes from unphased genotype data. We optimize a likelihood closely related to the PHASE model (which is considered one of the most accurate), and we show that the proposed approach is substantially more accurate than recent alternatives. The work in these chapters contributes to common and important tasks in analysis of genomic data for association studies.
  • EGFR inhibitors in cancer treatment / Fortunato Ciardiello -- Mechanisms of action of EGFR inhibitors / Nicola Normanno, Maria Pergameno, Alessia Iannaccone & Antonella De Luca -- Selection of NSCLC patients to treat with EGFR inhibitors in the era of personalized medicine / Rafael Rosell, Laura Bonanno & Miquel Taron -- Clinical results with EGFR inhibitors in NSCLC and their use in the treatment of metastatic disease / Cesare Gridelli & Antonio Rossi -- Clinical results with EGFR inhibitors in colorectal cancer / Erika Martinelli, Teresa Troiani, Floriana Morgillo & Fortunato Ciardiello -- EGFR-directed therapies in squamous cell carcinoma of the head and neck / Pol Specenier & Jan B. Vermorken -- Optimal use of EGFR inhibitors : challenges, new drugs and future directions / Sara De Dosso, Rodrigo Dienstmann & Josep Tabernero.
  • The debate over eHealth is alive as never before. Supporters suggest that it will result in dramatic innovations in healthcare, including a giant leap towards patient-centered care, new opportunities to improve effectiveness, and enhanced wellness and quality of life. In addition, the growing market value of investments in health IT suggests that eHealth can offer at least a partial cure for the current economic stagnation. Detractors counter these arguments by claiming that eHealth has already failed: the UK Department of Health has shut down the NHS National Program for IT, Google has discontinued its Health flagship, and doubts have arisen over privacy safeguards for both patients and medical professionals. This book briefly explains why caregivers, professionals, technicians, patients, politicians, and others should all consider themselves stakeholders in eHealth. It offers myth-busting responses to some ill-considered arguments from both sides of the trench, in the process allowing a fresh look at eHealth. In addition, it describes how the technical failures of previous eHealth systems can be avoided, examines the legal basis of eHealth, and discusses associated ethical issues.
  • An overview of healthcare disparities -- Provider factors in healthcare disparities -- Patient factors in healthcare disparities -- Healthcare system factors in healthcare disparities -- The social "nonmedical" determinants of health -- The role of the Internet in American life -- The iHealth revolution -- Digital disparities -- The role of eHealth in patient engagement and quality improvement -- Medical informatics -- Public health informatics -- Beyond traditional paradigms in disparities research -- Health information technology policy perspectives and healthcare disparities -- Disparities and eHealth: achieving the promise and the potential.
  • Eiger is the sole TNF family member found in Drosophila melanogaster. This signaling molecule is induced during infection and is required for an appropriate immune response to many microbes; however, little is known concerning where eiger is produced and what genes are regulated by eiger. Here we show that eiger is made in the fly's fat body during a Salmonella typhimurium infection. Using tissue specific knockdowns we found that eiger expression in the fat body is required for all of the phenotypes we observed in eiger null mutant flies. This includes reduced melanization, altered antimicrobial peptide expression and reduced feeding rates. The effect of eiger on feeding rates alone may account for the entire phenotype seen in eiger mutants infected with S. typhimurium. We further characterized the eiger response using transcriptional arrays. We found that the eiger regulates a number of genes involved in metabolism and hormonal signaling during an immune response. How these genes are involved in the immune response is not clear. Finally we examined the role of age related decline of the immune system in D. melanogaster during bacterial infection. We found that vigor and tolerance are reduced when old flies are challenged with a variety of bacterial pathogens.
  • Also available: Print – 1908-
    T. 1. Einführung in das Wesen der Magen-, Darm- und Stoffwechsel-Krankheiten.
  • Print Material
  • Also available: Print – 2009
  • Elbow arthroscopy 2013
    Anatomy and Portals -- Arthroscopic Technique -- Osteochondritis Dissecans Lesions and Loose Bodies of the Elbow -- Arthroscopic Treatment of Lateral Epicondylitis -- Elbow Arthroscopy in Stiff Elbow -- The Role of Arthroscopy in Elbow Instability -- Endoscopy Around the Elbow -- Arthroscopic Treatment of Elbow Fractures -- Elbow Arthroscopy Complications -- Elbow Arthroscopy: The Future.
  • Part I. Exposures -- part II. Fractures and trauma -- part III. Complications of trauma -- part IV. Soft tissue injuries and management -- part V. Nonreplacement and reconstructive surgery -- part VI. Joint replacement arthroplasty -- part VII. Postoperative management.
  • Clinically Relevant Elbow Anatomy and Surgical Approaches -- Ulnar Collateral Ligament: Throwing Biomechanics -- Valgus Extension Overload -- Ulnohumeral Chondral and Ligamentous Overload -- Epidemiology of Elbow Ulnar Collateral Ligament Injuries -- History and Physical Exam on the Thrower{u2019}s Elbow -- Radiographic Imaging of the Elbow -- MR Imaging in Patients with Ulnar Collateral Ligament Injury -- Ultrasound Imaging of Ulnar Collateral Ligament Injury -- The Conservative Treatment of Ulnar Collateral Ligament Injuries -- Injections Including Platelet Rich Plasma -- Ulnar Collateral Ligament Reconstruction: Graft Selection and Harvest Technique -- Primary Repair of Ulnar Collateral Ligament Injuries of the Elbow -- The Role of Arthroscopy in Athletes with Ulnar Collateral Ligament Injuries -- Biomechanics of Reconstruction Constructs -- Figure of 8 Technique and Outcomes -- Ulnar Collateral Ligament Reconstruction: Docking Technique -- American Sports Medicine Institute Techniques and Outcomes -- Ulnar Collateral Ligament Reconstruction: Alternative Surgical Techniques -- Combined Flexor-Pronator Mass and Ulnar Collateral Ligament Injuries -- Ulnar Nerve Issues in Throwing Athletes -- Revision Ulnar Collateral Ligament Reconstruction -- Ulnar Collateral Ligament Injuries in High School-Aged Athletes -- Ulnar Collateral Ligament Injury in Female Athletes -- Complications of Ulnar Collateral Ligament Repair -- Sports Specific Outcomes for Ulnar Collateral Ligament Reconstruction -- Rehabilitation of the Overhead Athlete{u2019}s Elbow -- Sport Specific Rehabilitation after Ulnar Collateral Ligament Surgery.
  • Electric Cell-Substrate Impedance Sensing Concept to Commercialization / Ivar Giaever and Charles R. Keese -- Protein Kinase C Isoforms in the Formation of Focal Adhesion Complexes: Investigated by Cell Impedance / Havovi Chichger, Katie L. Grinnell and Elizabeth O. Harrington -- ECIS as a Tool in the Study of Metastasis Suppressor Genes: Epithelial Protein Lost In Neoplasm (EPLIN) / Andrew J. Sanders, Vladimir M. Saravolac, Malcolm D. Mason and Wen G. Jiang -- Electrical Cell-Substrate Impedance Sensing for Measuring Cellular Transformation, Migration, Invasion, and Anticancer Compound Screening / Bryan Plunger, Chang Kyoung Choi and Tim E. Sparer -- Epithelial-Mesenchymal Transition and the Use of ECIS / Jane Lane and Wen G. Jiang -- Cell Growth and Cell Death Studied by Electric Cell-Substrate Impedance Sensing / Judith Anthea Stolwijk, Stefanie Michaelis and Joachim Wegener -- Tight Junctions in Cancer Metastasis and Their Investigation Using ECIS (Electric Cell-Substrate Impedance Sensing) / Tracey A. Martin and Wen G. Jiang -- Epithelial Wound Healing and the Effects of Cytokines Investigated by ECIS: Electric Cell-Substrate Impedance Sensing in Epithelial Research / Katalin Szaszi, Matthew Vandermeer and Yasaman Amoozadeh -- Tumour-Endothelial and Tumour-Mesothelial Interactions Investigated by Impedance Sensing Based Cell Analyses / Wen G. Jiang, Lin Ye, Haiying Ren, Ann Kift-Morgan and Nicholas Topley, et al. -- Application of Electric Cell-Substrate Impedance Sensing in Evaluation of Traditional Medicine on the Cellular Functions of Gastric and Colorectal Cancer Cells / Lin Ye, Ke Ji, Jiafu Ji, Rachel Hargest and Wen G. Jiang -- Electric Cell-Substrate Impedance Sensing as a Screening Tool for Wound Healing Agents / Cheuk Lun Liu, Jacqueline Chor Wing Tam, Andrew J. Sanders, David G. Jiang and Chun Hay Ko, et al. -- ECIS, Cellular Adhesion and Migration in Keratinocytes / David C. Bosanquet, Keith G. Harding and Wen G. Jiang -- Current and Future Applications of ECIS Models to Study Bone Metastasis / Lin Ye, Sivan M. Bokobza, Howard G. Kynaston and Wen G. Jiang.
  • The past two decades have witnessed an explosion of knowledge and radical changes in our understanding of the molecular, ionic, genetic, and pharmacologic basis of electrical diseases of the heart. Electrical diseases of the heart are heritable arrhythmogenic clinical entities that may share common clinical and genetic features, yet may be distinctly different in their genesis, prognosis, and management. Notably, both congenital and acquired electrical diseases of the heart are receiving increased recognition as a result of important advances in genetic analysis. In this second edition of Electrical Diseases of the Heart, the Editors' goal has been to embrace and highlight the explosion of knowledge that our field has witnessed since the publication of the first edition. The approach continues to be one of bridging basic and clinical science in an attempt to advance meaningfully our understanding of heart disease and identify the knowledge gaps that exist. This volume covers the basic foundations and primary electrical diseases and with the companion volume provides the latest developments in the field of experimental and clinical cardiac electrophysiology, genetics, pharmacology and interventional therapies of various clinical arrhythmogenic entities. Residents, fellows and physicians in cardiology and electrophysiology will gain valuable insight into the latest developments in the field of cardiac electrophysiology and clinical electrocardiology by reading this book, including expert review of the genetic and epidemiologic considerations, diagnostic and therapeutic modalities of the newly discovered clinical syndromes and electrocardiographic phenomena, and their correlation with the most recent advances in the basic science.
  • Part I. Secondary Hereditary and Acquired Cardiac Channelopathies and Sudden Cardiac Death. Introduction to Part Three: Cardiac Remodeling / N. A. Mark Estes III -- Arrhythmias and Arrhythmia Management in Hypertrophic Cardiomyopathy / J. Martijn Bos, Steve R. Ommen, Michael J. Ackerman -- Sudden Cardiac Death in Dilated Cardiomyopathy and Skeletal Muscular Dystrophy / Ingrid A. W. van Rijsingen, Anneke J. van der Kooi, Yigal M. Pinto -- Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia / Hugh Calkins, Frank Marcus -- The Wolff-Parkinson-White Syndrome and the Risk of Sudden Death / Michael H. Gollob ... [et al.] -- Acquired (Drug-Induced) Long and Short QT Syndromes / Rashmi R. Shah, Ihor Gussak -- Acquired Form of Brugada Syndrome / Wataru Shimizu -- Part II. Clinical Rhythmology: Diagnostic Methods and Tools. Introduction to Part IV: Abnormal Electrical Functions of the Heart and Their Diagnoses in Clinic / Benjamin C. Eloff -- Diagnostic Electrocardiography / Preben Bjerregaard -- Microvolt T Wave Alternans: Mechanisms and Implications for Prediction of Sudden Cardiac Death / Florian Rader, Lance D. Wilson, Ottorino Costantini -- Heart Rate Variability: Measurements and Risk Stratification / Yi Gang -- Orthostatic Challenge Tests: Active Standing and Head-Up Tilt / Louise R. A. Olde Nordkamp, Nynke van Dijk, Wouter Wieling -- Signal Averaged ECG / Gioia Turitto ... [et al.] -- Surface Mapping and Magneto-Electrocardiography / Satsuki Yamada, Akihiko Kandori -- Ambulatory Monitoring: (Holter, Event Recorders, External, and Implantable Loop Recorders and Wireless Technology) / Rajesh N. Subbiah, Pow-Li Chia, Peter Leong-Sit -- Device Therapy for Remote Patient Management / Dwight W. Reynolds, Christina M. Murray, Robin Germany -- Invasive Electrophysiologic Testing: Role in Sudden Death Prediction / Jan Němec, Win-Kuang Shen -- Provocative (Drug) Testing in Inherited Arrhythmias / Wataru Shimizu, Michael J. Ackerman -- Novel Predictors of Sudden Cardiac Death / Sumeet S. Chugh, Rasmus Havmöller, Carmen Teodorescu -- Genetic Testing / David J. Tester, Michael J. Ackerman -- Part III. Risk Stratification of Sudden Cardiac Death in Acquired Clinical Conditions. Introduction to Part Five: Screening for Risk of Sudden Cardiac Death / John B. Kostis -- Risk Stratification for Sudden Death in Patients with Coronary Artery Disease / Emerson H. Liu, Lilian P. Joventino, Alfred E. Buxton -- Sudden Death in Athletes / Domenico Corrado, Anna Baritussio, Mariachiara Siciliano -- Cardiac Channelopathies and Sudden Infant Death Syndrome / Peter J. Schwartz, Marco Stramba-Badiale, John R. Giudicessi -- Heart Failure and Sudden Death / Yong-Mei Cha, Win-Kuang Shen -- Neurologic Conditions and Sudden Death / David M. Ficker, Elson L. So -- Sudden Cardiac Death and Alcohol / Vincent M. Figueredo, Bhaskar Purushottam -- Sudden Cardiac Death and Addictive Chemical Substances / Bhaskar Purushottam, Vincent M. Figueredo -- Obstructive Sleep Apnea and Sudden Death / Apoor S. Gami, Virend K. Somers -- Sudden Cardiac Arrest in Chronic Kidney Disease / Rod Passman, Mai Ots-Rosenberg, Ihor Gussak -- Clinical Trials in Sudden Cardiac Death Prevention: Principles and Endpoints / Andrzej S. Kosinski -- Part IV. Treatment and Prevention Modalities. Introduction to Part IV: Treatment Modalities / Mark E. Josephson -- Clinical Role of Antiarrhythmic Drugs in the Prevention of Sudden Death / Hon-Chi Lee, Kristin T. L. Huang -- Non-antiarrhythmic Drugs in Sudden Death Prevention / Leonard Ilkhanoff, Alan H. Kadish, Jason T. Jacobson -- Non-surgical Treatment and Prevention of Atrial Fibrillation / Patricia Tung, Peter J. Zimetbaum -- Surgical Treatment of Atrial Fibrillation / John M. Stulak, Hartzell V. Schaff -- Catheter Ablation for Triggered Ventricular Fibrillation and Polymorphic Ventricular Tachycardia / Frédéric Sacher ... [et al.] -- Catheter Ablation for Scar-Dependent Ventricular Tachycardia / Roy M. John, William G. Stevenson -- The Implantable Cardioverter Defibrillator: Technical and Clinical Considerations / Bruce L. Wilkoff, Sergio G. Thal -- Beyond Sudden Death Prevention: Minimizing ICD Shocks and Morbidity, and Optimizing Efficacy / Eyal Nof ... [et al.] -- Pacing and Cardiac Resynchronization / Robert F. Rea.
  • "This book will enable the reader to gain a sound understanding of contemporary and futuristic evidence-based interventions and assessment procedures for pelvic floor disorders. It gathers the experiences of some of the most important experts on electrical stimulation techniques, offering a multidisciplinary and problem-oriented approach organized according to therapeutic goals. Interventions are recommended that are consistent with theory and display clinical efficacy for specific disorders, including urinary incontinence or retention, fecal incontinence, constipation, pelvic pain, sexual dysfunction, and neurological diseases involving the pelvic floor. All of the surgical or rehabilitative techniques requiring electrical stimulation for the treatment of these disorders are explored, and essential background information is provided on functional anatomy, neurophysiology, and concepts in electrotherapy. This volume will be a very useful tool for urologists, general or colorectal surgeons, gynecologists, and anesthesiologists, and also physiotherapists and alternative medicine practitioners (a specific chapter focuses on electroacupuncture). It will assist in their clinical practice as they seek to help the very many patients who suffer from any of the wide range of functional pelvic floor disorders"--Publisher's description.
  • Also available: Print – 2001
  • Print Material
  • Important concepts -- Sinus node dysfunction -- Atrioventricular conduction abnormalities -- Junctional tachycardia -- Atrioventricular nodal reentrant tachycardia (AVNRT) -- Atrioventricular reentrant tachycardias : concealed -- Accessory pathways and Wolff-Parkinson-White (WPW) -- Syndrome and variants -- Atrial tachycardias -- Atrial flutter -- Atrial fibrillation -- Wide complex tachycardia (supraventricular with abberancy -- Vs.ventricular tachycardia) -- Ventricular tachycardia (VT) in structural heart disease -- Ventricular tachycardia in patients with normal hearts -- Polymorphic VT and ventricular fibrillation (VF).
  • Electrocardiography of Laboratory Animals is the only book covering electrocardiography of laboratory animals, including dogs, mini-pigs, and cynomologus monkeys. As more countries institute requirements for the care of laboratory animals in research, this publication offers an effective standard on performing and analyzing ECGs. Topics covered include safety electrocardiography, toxicology, safety pharmacology, and telemetry. Electrocardiography of Laboratory Animals will assist biological and medical researchers, veterinarians, zoologists, and students in understanding electrocardiography of various species of animals used in research. Covers safety electrocardiography of large laboratory animals. Offers comprehensive analysis of ECGs for practical laboratory use. Includes a self-evaluation section for testing of ECG reading and analysis.
  • An introduction to electrochemical methods in neuroscience / Laura M. Borland and Adrian C. Michael -- Rapid dopamine release in freely moving rats / Donita L. Robinson and R. Mark Wightman -- Presynaptic regulation of extracellular dopamine as studied by continuous amperometry in anesthetized animals / Marianne Benoit-Marand, Marie-Francoise Suaud-Chagny, and François Gonon -- Fast scan cyclic voltammetry of dopamine and serotonin in mouse brain slices / Carrie E. John and Sara R. Jones -- High-speed chronoamperometry to study kinetics and mechanisms for serotonin clearance in vivo / Lynette C. Daws and Glenn M. Toney -- Using high-speed chronoamperometry coupled with local dopamine application to assess dopamine transporter function / Joshua M. Gulley, Gaynor A. Larson, and Nancy R. Zahniser -- Determining serotonin and dopamine uptake rates in synaptosomes using high-speed chronoamperometry / Xiomara A. Perez, Amanda J. Bressler, and Anne Milasincic Andrews -- Using fast-scan cyclic voltammetry to investigate somatodendritic dopamine release / Sarah Threlfell and Stephanie J. Cragg -- From interferant anion to neuromodulator : ascorbate oxidizes its way to respectability / George V. Rebec -- Biophysical properties of brain extracellular space explored with ion-selective microelectrodes, integrative optical imaging and related techniques / Sabina Hrabetová and Charles Nicholson -- Hydrogen peroxide as a diffusible messenger : evidence from voltammetric studies of dopamine release in brain slices / Margaret E. Rice, Marat V. Avshalumov, and Jyoti C. Patel -- In vivo voltammetry with telemetry / Paul A. Garris ... [et al.] -- Oxidative stress at the single cell level / Christian Amatore and Stephane Arbault -- Electrochemistry at the cell membrane/solution interface / Nathan Wittenberg ... [et al.] -- The patch amperometry technique : design of a method to study exocytosis of single vesicles / Gregor Dernick, Guillermo Alvarez de Toledo, and Manfred Lindau -- Amperometric detection of dopamine exocytosis from synaptic terminals / Roland G.W. Staal, Stephen Rayport, and David Sulzer -- Scanning electrochemical microscopy as a tool in neuroscience / Albert Schulte and Wolfgang Schuhmann -- Principles, development and applications of self-referencing electrochemical microelectrodes to the determination of fluxes at cell membranes / Peter J.S. Smith, Richard H. Sanger, and Mark A. Messerli -- Second-by-second measures of L-glutamate and other neurotransmitters using enzyme-based microelectrode arrays / Kevin N. Hascup ... [et al.] -- Telemetry for biosensor systems / David A. Johnson and George S. Wilson -- The principles, development and application of microelectrodes for the in vivo determination of nitric oxide / Michael J. Serpe and Xueji Zhang -- In vivo fast-scan cyclic voltammetry of dopamine near microdialysis probes / Hua Yang and Adrian C. Michael.
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  • 1. Principles and methods. Full-field electroretinograms -- Focal macular ERGs -- Multifocal ERGs -- Electrooculography -- Optical coherence tomography -- 2. Hereditary retinal and allied diseases. Retinitis pigmentosa -- Crystalline retinopathy (Bietti) -- Batten disease -- Kearns-Sayre syndrome -- Choroideremia -- Gyrate atrophy -- Enhanced s-cone syndrome -- X-linked retinoschisis -- Nettleship-falls x-linked ocular albinism -- Complete and incomplete types of CSNB -- Fundus albipunctatus -- Oguchi's disease -- Cone dystrophy -- Rod monochromacy -- Blue cone monochromacy -- Congenital tritanopia - differential diagnosis of dominantly inherited juvenile optic atrophy -- Rod-cone dysfunction syndrome with an unusual form of ERG -- Association of negative ERG with diseases of unknown etiology -- Occult macular dystrophy -- Stargardt's disease (fundus flavimaculatus) -- Best's disease -- 3. Acquired retinal diseases. Diabetic retinopathy -- Retinal circulatory disturbances -- Retinal and choroidal detachment -- Inflammatory diseases of retina and choroid -- 4. Acquired macular diseases. Central serous chorioretinopathy -- Aphakic or pseudophakic cystoid macular edema -- Idiopathic epimacular membranes -- Foveal thickness and focal macular ERG -- Idiopathic macular hole -- Macular pseudohole -- Age-related macular degeneration.
  • Also available: Print – 2005
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  • 2013 ClinicalKey
    Approach to Nerve Conduction Studies and Electromyography -- Anatomy and Neurophysiology -- Basic Nerve Conduction Studies -- Late Responses -- Blink Reflex -- Repetitive Nerve Stimulation -- Anomalous Innervations -- Artifacts and Technical Factors -- Basic Statistics for Electrodiagnostic Studies -- Routine Upper Extremity, Facial, and Phrenic Nerve Conduction Techniques -- Routine Lower Extremity Nerve Conduction Techniques -- Basic Overview of Electromyography -- Anatomy for Needle Electromyography -- Basic Electromyography: Analysis of Spontaneous Activity -- Basic Electromyography: Analysis of Motor Unit Action Potentials -- Clinical-Electrophysiologic Correlations: Overview and Common Patterns -- Median Neuropathy at the Wrist -- Proximal Median Neuropathy -- Ulnar Neuropathy at the Elbow -- Radial Neuropathy -- Peroneal Neuropathy -- Femoral Neuropathy -- Tarsal Tunnel Syndrome -- Facial and Trigeminal Neuropathy -- Polyneuropathy -- Amyotrophic Lateral Sclerosis and its Variants -- Atypical Motor Neuron Disorders -- Radiculopathy -- Brachial Plexopathy -- Proximal Neuropathies of the Shoulder and Arm -- Lumbosacral Plexopathy -- Sciatic Neuropathy -- Neuromuscular Junction Disorders -- Myopathy -- Myotonic Muscle Disorders and Periodic Paralysis Syndromes -- Approach to Electrodiagnostic Studies in the Intensive Care Unit -- Approach to Pediatric Electromyography -- Basics of Electricity and Electronics for Electrodiagnostic Studies -- Electrical Safety and Iatrogenic Complications of Electrodiagnostic Studies.
  • Also available: Print – 2007
    The scope of the EMG examination -- Routine clinical electromyography -- Specialized electrodiagnostic studies -- Electrodiagnostic findings in neuromuscular disorders.
  • Introduction to electron crystallography / Werner Kuhlbrandt -- Practical aspects in expression and purification of membrane proteins for structural analysis / Kutti R. Vinothkumar, Patricia C. Edwards, and Joerg Standfuss -- Two-dimensional crystallization of membrane proteins by reconstitution through dialysis / Matthew C. Johnson [and others] -- Monolayer two-dimensional crystallization of membrane proteins / Luc Lebeau and Catherine Venien-Bryan -- Screening for two-dimensional crystals by transmission electron microscopy of negatively stained samples / Tina M. Dreaden [and others] -- Low dose techniques and cryo-electron microscopy / Yoshinori Fujiyoshi -- Grid preparation for cryo-electron microscopy / Nobuhiko Gyobu -- Recording high-resolution images of two-dimensional crystals of membrane proteins / Agustin Avila-Sakar [and others] -- Collection of high-resolution electron diffraction data / Tamir Gonen -- Image processing of 2D crystal images / Marcel Arheit [and others] -- Merging of image data in electron crystallography / Marcel Arheit [and others] -- Evaluation of electron crystallographic data from images of two-dimensional crystals / Vinzenz M. Unger -- Modeling, docking, and fitting of atomic structures to 3D maps from cryo-electron microscopy / Gregory S. Allen and David L. Stokes -- Phasing electron diffraction data by molecular replacement : strategy for structure determination and refinement / Goragot Wisedchaisri and Tamir Gonen -- High-throughput methods for electron crystallography / David L. Stokes [and others] -- Automated grid handling and image acquisition for two-dimensional crystal screening / Anchi Cheng -- Automation of data acquisition in electron crystallography / Anchi Cheng -- Automation of image processing in electron crystallography / Marcel Arheit [and others] -- Choice and maintenance of equipment for electron crystallography / Deryck J. Mills and Janet Vonck -- Future developments in instrumentation for electron crystallography / Kenneth H. Downing -- Tubular crystals and helical arrays : structural determination of HIV-1 capsid assemblies using iterative helical real-space reconstruction / Peijun Zhang, Xin Meng, and Gongpu Zhao -- Single particle electron microscopy / Wilson C.Y. Lau and John L. Rubinstein -- Electron tomography of paracrystalline 2D arrays / Hanspeter Winkler, Shenping Wu, and Kenneth A. Taylor -- High-resolution imaging of 2D outer membrane protein F crystals by atomic force microscopy / Dimitrios Fotiadis and Daniel J. Muller -- Determination of soluble and membrane protein structures by x-ray crystallography / Raquel L. Lieberman, Mary E. Peek, and J. Derrick Watkins -- Solution nuclear magnetic resonance spectroscopy / James J. Chou and Remy Sounier -- Structure-function insights of membrane and soluble proteins revealed by electron crystallography / Tina M. Dreaden [and others] -- Lipid monolayer and sparse matrix screening for growing two-dimensional crystals for electron crystallography : methods and examples / Mark Yeager, Kelly A. Dryden, and Barbie K. Ganser-Pornillos -- Processing of electron diffraction patterns with the XDP program / Kaoru Mitsuoka -- Future directions of electron crystallography / Yoshinori Fujiyoshi.
  • Conventional specimen preparation techniques for transmission electron microscopy of cultured cells / John J. Bozzola -- Processing biological tissues for ultrastructural study / José A. Mascorro and John J. Bozzola -- Processing plant tissues for ultrastructural study / John Kuo and Ivan Kuo -- Microwave-assisted processing and embedding for transmission electron microscopy / Paul Webster -- Ultramicrotomy for biological electron microscopy / Herbert K. Hagler -- Poststaining grids for transmission electron microscopy : conventional and alternative protocols / E. Ann Ellis -- Negative staining of thinly spread biological samples / J. Robin Harris -- Recent advances in high-pressure freezing : equipment- and specimen-loading methods / Kent L. McDonald ... [et al.] -- Cryo-ultramicrotomy : cryo-electron microscopy of vitreous sections / Dimitri Vanhecke, Luca Studer, and Daniel Studer -- Cell-free extract systems and the cytoskeleton : preparation of biochemical experiments for transmission electron microscopy / Margaret Coughlin, William M. Brieher, and Ryoma Ohi -- Electron microscopy/in situ hybridization tracking of DNA and RNA sequences at high resolution / Dusan Cmarko and Karel Koberna -- Correlative light and electron microscopy using immunolabeled resin sections / Heinz Schwarz and Bruno M. Humbel -- Cryosectioning fixed and cryoprotected biological material for immunocytochemistry / Paul Webster and Alexandre Webster -- F-TEM images : integrating fluorescence microscopy with transmission electron microscopy / Paul A. Sims and Jeff D. Hardin -- Quantitative immunoelectron microscopy : alternative ways of assessing subcellular patterns of gold labelling / Terry M. Mayhew -- Electron crystallography of membrane proteins / Hui-Ting Chou, James Evans, and Henning Stahlberg -- Cryo-electron microscopy of icosahedral virus particle / Wen Jiang and Wah Chiu -- 3D reconstructions of chromosomes with electron tomography / Peter Engelhardt -- Whole-mount immuno-electron tomography of chromosomes and cells / Peter Engelhardt ... [et al.] -- 3D cryo-transmission electron microscopy of cells and organelles / Michael Marko and Chyong-Ere Hsieh -- Electron energy-loss spectroscopy (EELS) as a tool for elemental analysis in biological specimens / Nadine Kapp ... [et al.] -- Conventional specimen preparation techniques for scanning electron microscopy of biological specimens / John J. Bozzola -- Variable pressure and environmental scanning electron microscopy : imaging of biological samples / Brendan J. Griffin -- Cryoplaning technique for visualizing the distribution of water in woody tissue by cryo-scanning electron microscopy / Yasuhiro Utsumi and Yuzou Sano -- X-ray microanalysis in the scanning electron microscope / Godfrield M. Roomans and Anca Dragomir -- Botanical SEM X-ray microanalysis in cryo-scanning electron microscopy / Beat Frey -- Static secondary ion mass spectrometry for biological and biomedical research / Nicholas P. Lockyer -- Using secondary ion mass spectrometry and multi-isotope imaging mass spectrometry in biological materials : application to higher plants / Nicole Grignon.
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  • Chapter 1. Electron Microscopy of Viruses -- Chapter 2. Bacterial TEM : New Insights from Cryo-Microscopy -- Chapter 3. Analysis of the Ultrastructure of Archaea by Electron Microscopy -- Chapter 4. Chlamydomonas : Cryopreparation Methods for the 3-D Analysis of Cellular Organelles -- Chapter 5. Ultrastructure of the Asexual Blood Stages of Plasmodium falciparum -- Chapter 6. Electron Tomography and Immuno-labeling of Tetrahymena thermophila Basal Bodies -- Chapter 7. Electron Microscopy of Paramecium (Ciliata).
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  • The Human Genome Project was accomplished by a reduction in the cost of DNA sequencing by three orders of magnitude. Further cost reductions are required for sequencing to become a standard tool in clinical medicine and to enable personalized medicine via individual genome sequencing. The current cost varies between $50k to $100k over a period of months; depend on the technology, accuracy and read-length. It is desired to reduce the cost to $1000 per genome to enable profiling of individuals genome. To achieve this goal, a highly integrated platform with simplified chemistry is required. In this dissertation, we introduce a novel method for DNA sequencing based on electrical detection of polymerization reaction, called "Thermo/pH sequencing". Our proposed method is based on the direct measurement of the heat release or the pH modulation (change of H+ ion concentration in the solution) during DNA extension. For high throughput DNA sequencing, DNA strands are immobilized to small micron-size beads in a microfluidic platform. The DNA-beads are in a reaction mixture in contact with an array of sensitive micro-machined heat or pH sensors, which detect the electrical signature from incorporation of a complementary base (dNTP) in the presence of appropriate reagents (DNA polymerase, and polymerase reaction buffer). This results to a label-free, long-read and fast chemistry; 10x reduction in reagent cost with 10x increase in throughput can potentially yield to significant improvement in the cost of genome sequencing to less than $1000. In addition, substituting optical detection set-up with microelectronic sensor reduces the capital cost of sequencing instruments from $500k to less than $50k. We demonstrate the proof of concept for this technology at large scale. Then we describe the development of an appropriate microfluidic platform and two micromachined electrical biosensors that employ electrical detection for heat or pH detection. Both versatile platforms can be multiplexed and have the potential of providing rapid and inexpensive measurements without any compromise in the sensitivity, making them good potential candidates for use in the clinical setting. We report a chip-based integrated differential microfluidic nanocalimeters with on-chip injection and multiplexing unit, capable of characterizing the heat of reaction with unprecedented 2-nW resolution in 1 Hz bandwidth for nanoliter scale samples. We successfully demonstrate DNA Thermosequencing with sequential injection of different nucleotides into the integrated microfluidic calorimeter device. In addition, the device can serve as a powerful tool to characterize a variety of the biomedical processes, such as metabolic activities of microorganisms, living cells and catalyzed reactions. We also present a microfabricated device in microfluidics for pH sequencing, called nanoneedle biosensor. The key element for this device is a 10nm wide gap on the end of the needle of total diameter about 100nm. Any change in the population of molecules in this gap results in a change of impedance across the gap; single molecule detection should be possible. In addition, DNA-beads can be allocated iv near the sensors to measure the pH change during DNA extension. The design, fabrication, testing, optimization and a modified structure of the device for higher signal to noise ratio are presented. Toward an integrated sequencer platform, automation and reduced labor cost, higher throughput, accuracy and efficiency for genomics and proteomics analysis; further integration and optimization of the presented systems are required. We envision the integration of our CMOS-compatible devices with a CMOS integrated circuitry into a high throughput gene sequencer or proteomics system. The proteomics system enables multiplex analysis using an array of micro-channels for probing clinically relevant samples such as the human serum for various protein and nucleic acid biomarkers for cancer detection, and also the detection of pathogenic bacteria in solution.
  • "This book introduces readers to structured systems analysis and the medications domains. It starts off with top-down decomposition of workflows and data. It applies structured systems analysis methodology and tools to electronic prescription, computerized physician order entry, drug dispensation, medication administration, and clinical decision support. Providing a comprehensive view of the EHR/EMR, the text covers user interface considerations, reporting requirements, and standards and vocabularies for meaningful use. Assuming no previous clinical and/or informatics knowledge, the author uses accessible language and includes over 250 figures and 100 review questions with answers"--Provided by publisher.
  • Part 1. Introduction -- part 2. Identifying and preventing EHR safety concerns -- part 3. EHR users and usability -- part 4. Clinical decision support -- part 5. Referrals -- part 6. Laboratory test result management -- part 7. Bar coded medication administration -- part 8. Computer-based provider order entry.
  • Introduction to e-Healthcare Information Security / Charles A. Shoniregun, Kudakwashe Dube and Fredrick Mtenzi -- Securing e-Healthcare Information / Charles A. Shoniregun, Kudakwashe Dube and Fredrick Mtenzi -- Laws and Standards for Secure e-Healthcare Information / Charles A. Shoniregun, Kudakwashe Dube and Fredrick Mtenzi -- Secure e-Healthcare Information Systems / Charles A. Shoniregun, Kudakwashe Dube and Fredrick Mtenzi -- Towards a Comprehensive Framework for Secure e-Healthcare Information / Charles A. Shoniregun, Kudakwashe Dube and Fredrick Mtenzi -- Towards a Unified Security Evaluation Framework for e-Healthcare Information Systems / Charles A. Shoniregun, Kudakwashe Dube and Fredrick Mtenzi -- Discussions / Charles A. Shoniregun, Kudakwashe Dube and Fredrick Mtenzi.
  • Also available: Print – 2012
    Chapter 1. Identifying general requirements -- Chapter 2. Identifying detailed requirements -- Chapter 3. Selecting a solution -- Chapter 4. Implementing an electronic recording and reporting system .
  • "The new edition of Electrophysiological Disorders of the Heart helps you diagnose and treat a full range of heart rhythm disorders using today's latest technologies and therapies. It provides practical, hands-on coverage of hot topics such as pediatric EP, imaging, echocardiography-guided EP procedures, regenerative therapies, cardiac pacing, and more. Now available in a new full-color format, the title also includes easy online access at "--Publisher's website.
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  • Field Potential Generation and Current Source Density Analysis / L. Stan Leung -- Current Source Density Analysis of Ongoing Neural Activity: Theory and Application / Yonghong Chen, Mukesh Dhamala, Anil Bollimunta, Charles E. Schroeder, Mingzhou Ding -- The Juxtacellular Recording-Labeling Technique / Didier Pinault -- Neural Recording Using Digital Telemetry / André A. Fenton, Kathryn J. Jeffery, James G. Donnett -- Large-Scale Neural Ensembles in Mice: Methods for Recording and Data Analysis / Hui Kuang, Joe Z. Tsien -- Behavioral Correlates of Neuronal Activity Recorded as Single-Units: Promises and Pitfalls as Illustrated by the Rodent Head Direction Cell Signal / Robert W. Stackman -- Event-Related Potentials of the Cerebral Cortex / Steven L. Bressler -- Multisite Spike-Field Coherence, Theta Rhythmicity, and Information Flow Within Papez's Circuit / Zimbul Albo, Gonzalo Viana Prisco, Robert P. Vertes -- Cognitively Relevant Recoding in Hippocampus: Beneficial Feedback of Ensemble Codes in a Closed Loop Paradigm / Robert E. Hampson, John D. Simeral, Theodore W. Berger, Dong Song, Rosa H. Chan, Vasilis Z. Marmarelis, Sam A. Deadwyler -- An Intact Septo-Hippocampal Preparation for Investigating the Mechanisms of Hippocampal Oscillation / Romain Goutagny, Jesse Jackson, Sylvain Williams -- Targeted Modulation of Neural Circuits: A New Treatment Strategy for Neuropsychiatric Disease / Helen S. Mayberg, Paul E. Holtzheimer.
  • Psychophysiology is an ever expanding field. The application of psychophysiological investigations to psychiatric disorders is likewise expanding and has in fact shed much light on some of the neural processes contributing to the development of psychiatric symptoms and/or their amelioration following treatment. The first part of this volume deals with a number of conditions where psychophysiological investigations have recently provided some insight into the pathophysiology of a particular manifestation (e.g., dissociation) or a disorder. Although this volume has a main focus on electrophysiological investigative modalities where neuroimaging was complimentary this added insight was included. The second part of the volume focuses on novel uses of psychophysiological measures, combining it with neuropsychology and imaging where possible, in the context of neuropsychiatric research and describes advanced analytical tools. Both basic and clinical investigators in this field should find the reviews and interpretations provided clear and informative. Clinicians will find this volume easy to assimilate. While direct clinical applications may be down the road, the insights provided should help the practicing clinicians to have firmer understanding of the complexity of the disorder they manage in everyday practice.
  • Pt. I. Basic concepts of DNA transfer via electroporation. Application of electroporation gene therapy: past, current, and future / Lluis M. Mir -- Mechanism by which electroporation mediates DNA migration and entry into cells and targeted tissues / Marie-Pierre Rols -- Applicator and electrode design for in vivo DNA delivery by electroporation / Dietmar Rabussay -- Electrode assemblies used for electroporation of cultured cells / Leda Raptis and Kevin L. Firth -- Formulations for DNA delivery via electroporation in vivo / Khursheed Anwer -- Overview of drug delivery and alternative methods to electroporation / Sek-Wen Hui -- Nanoelectroporation: a first look / Raji Sundararajan -- Pt. II. In vitro targeted gene delivery via electroporation. Nucleofection of human embryonic stem cells / Henrike Siemen ... [et al.] -- Delivery of whole tumor lysate into dendritic cells for cancer vaccination / Linda N. Liu ... [et al.] -- Delivery of tumor-antigen-encoding mRNA into dendritic cells for vaccination / Annelies Michiels ... [et al.] -- Delivery of DNA into natural killer cells for immunotherapy / Kathrin Schoenberg, Hans-Ingo Trompeter, and Markus Uhrberg -- Electroporation of adherent cells in situ for the study of signal transduction and gap junctional communication / Leda Raptis ... [et al.] -- Delivery of DNA into adipocytes within adipose tissue / James G. Granneman -- Pt. III. In vivo targeted gene delivery via electroporation. Delivery of DNA into muscle for treating systemic diseases: advantages and challenges / Capucine Trollet, Daniel Scherman, and Pascal Bigey -- Delivery of DNA into skeletal muscle in large animals / Patricia A. Brown, Amir S. Khan, and Ruxandra Draghia-Akli -- Delivery of DNA into skin via electroporation / Babu M. Medi and Jagdish Singh -- Electroporation-mediated gene delivery to the lungs / Rui Zhou, James E. Norton, and David A. Dean -- Delivery of DNA into bladder via electroporation / Masaki Yoshida ... [et al.] -- Analysis of gene function in the retina / Takahiko Matsuda and Constance L. Cepko -- Optical in vivo imaging of electrically mediated delivery of siRNA into muscle for gene function analysis / Muriel Golzio and Justin Teissie -- Electroporation of adult zebrafish / N. Madhusudhana Rao, K. Murali Rambabu, and S. Harinarayana Rao -- Pt. IV. Treatment of cancer via electroporation gene therapy. Flow electroporation with pulsed electric fields for purging tumor cells / Abie Craiu and David Scadden -- Delivery of DNA into tumors / Shulin Li -- Intraturmoral bieomycin and IL-12 electrochemogenetherapy for treating head and neck tumors in dogs / Jeffry Cutrera ... [et al.] -- Systemic IL-12 gene therapy for treating malignancy via intramuscular electroporation / Shiguo Zhu and Shulin Li -- Treatment of SCCVII tumors with systemic chemotherapy and interleukin-12 gene therapy combination / Marina Torrero and Shulin Li -- Electroporation for drug and gene delivery in the cliic: doctors go electric / Julie Gehl -- IL-2 plasmid electroporation: from preclinical studies in phase I clinical trial / Holly M. Horton, Peggy A. Lalor, and Alain P. Rolland -- Pt. V. Treatment of other diseases via electroporation gene therapy. Factor IX gene therapy for hemophilia / James G. Fewell -- KGF-1 for wound healing in animal models / Guy P. Marti ... [et al.] -- Hapatocyte growth factor gene therapy for hypertension / Kazuo Komamura ... [et al.] -- Electroporation of corrective nucleic acids (CNA) in vivo to promote gene correction in dstrophic muscle / Robert M.I. Kapsa, Sharon H.A. Wong, and Anita F. Quigley -- Gene delivery to dystrophic muscle / Kim E. Wells ... [et al.] -- Effect of electroporation on cardiac electrophysiology / Vadim V. Fedorov, Vladimir P. Nikolski, and Igor R. Efimov -- Muscle and fat mass modulation in different clinical models / Ruxandra Draghia-Akli and Amir S. Khan -- Pt. VI. Applications of electroporation for DNA vaccination. DNA vaccination for prostate cancer / Anna-Karin Roos, Alan King, and Pavel Pisa -- HER2/neu DNA vaccination for breast tumors / Arianna Smorlesi ... [et al.] -- Electroporation-mediated HBV DNA vaccination in primate models / Yong-Gang Zhao and Yuhong Xu -- Taking electroporation-based delivery of DNA vaccination into humans: a generic clinical protocol / Torunn Elisabeth Tjelle ... [et al.] -- Production of monoclonal antibody by DNA immunization with electroporation / Kaw Yan Chua, John D.A. Ramos, and Nge Cheong.
  • Electroreception 2005
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  • ch. 1. Introduction and preview -- ch. 2. Entropy, relative entropy, and mutual information -- ch. 3. Asymptotic equipartition property -- ch. 4. Entropy rates of a stochastic process -- ch. 5. Data compression -- ch. 6. Gambling and data compression -- ch. 7. Channel capacity -- ch. 8. Differential entropy -- ch. 9. Gaussian channel -- ch. 10. Rate distortion theory -- ch. 11. Information theory and statistics -- ch. 12. Maximum entropy -- ch. 13. Universal source coding -- ch. 14. Kolmogorov complexity -- ch. 15. Network information theory -- ch. 16. Information theory and portfolio theory -- ch. 17. Inequalities in information theory.
  • ch. 1. Introductory orientation -- ch. 2. The Conformation of informational macromolecules -- ch. 3. Information processing in cells -- ch. 4. Molecular evolution -- ch. 5. Manipulating biomolecules -- ch. 6. Genomics -- ch. 7. Biomembranes -- ch. 8. G-protein-coupled receptors -- ch. 9. Pumps -- ch. 10. Ligand-gated ion channels -- ch. 11. Voltage-gated channels -- ch. 12. Resting potentials and cable conduction -- ch. 13. Sensory transduction -- ch. 14. The Action potential -- ch. 15. The Neuron as a secretory cell -- ch. 16. Neurotransmitters and neuromodulators -- ch. 17. The Postsynaptic cell -- ch. 18. Developmental genetics of the brain -- ch. 19. Epigenetics of the brain -- ch. 20. Memory -- ch. 21. Some pathologies.
  • Rick's Big Adventure -- All My Trials -- Fish Ate My Cancer -- Smoker's Cough -- Conference With Counsel -- Coming Through -- Here's Henry -- Why Me? -- How Do They Know What I've Got? -- Doctors and Cancer: Firewall.
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  • I. Underlying causes of healthcare disparities -- 1. Historical perspectives on healthcare disparities : is the past prologue? / Richard Allen Williams -- 2. Epidemiology of racial and ethnic disparities in health and healthcare / George A. Mensah and Maleeka J. Glover -- 3. Cultural diversity in medicine and in healthcare delivery / Richard Allen Williams -- II. Current problems -- 4. Healthcare and the politics of race / M. Gregg Bloche -- 5. Barriers to eliminating disparities in clinical practice: lessons from the IOM report "Unequal Treatment" / Joseph R. Betancourt and Angela Maina -- 6. Second-class medicine: implications of evidence-based medicine for improving minority access to the correct pharmaceutical therapy / Randall W. Maxey and Richard Allen Williams -- 7. The diversity benefit: how does diversity among health professionals address public needs? / Brian D. Smedley -- III. Approaches to correcting the problems -- 8. Eliminating disparities in healthcare through quality improvement / Kevin Fiscella -- 9. Eliminating racial discrimination in healthcare: a call for state healthcare anti-discrimination law / Vernellia R. Randall -- 10. Quality of care and health disparities: the evolving role of government / Garth N. Graham -- 11. The role of communities in eliminating healthcare disparities: getting down to the grass roots / JudyAnn Bigby -- 12. The potential impact of performance incentive programs on racial disparities in healthcare / Alyna T. Chien -- IV. Examples of what works -- 13. Monitoring socioeconomic determinants for healthcare disparities: tools from the Public Health Disparities Geocoding Project / Nancy Krieger ... [et a.] -- 14. The Association of Black Cardiologists: a small-group success story / Richard Allen Williams -- 15. Breathe easy in Seattle: addressing asthma disparities through healthier housing / James W. Krieger ... [et al.] -- 16. Access Health Solutions: a minority physician network model that works / Kathy B. Jackson -- 17. Carolinas Association for Community Health Equity-CACHE: a community coalition to address health disparities in racial and ethnic minorities in Mecklenburg County North Carolina / Yele Aluko -- V. Concluding recommendations -- 18. Principles for eliminating racial and ethnic disparities in healthcare / John Z. Ayanian and Richard Allen Williams.
  • ELISA guidebook. 2nd ed. 2009
    Springer Protocols
  • A biographical sketch of Elisha Bartlett. Early life and education -- Medical education -- Life in Lowell -- The peripatetic professor -- Return to Rhode Island -- Philosophy of medicine in the nineteenth century. Early nineteenth century American medicine -- The Paris Clinical School -- Influence of the Paris Clinical School in America -- Elisha Bartlett's philosophy of medicine. An introductory lecture on the objects and nature of medical science -- An essay on the philosophy of medical science -- An inquiry into the degree of certainty of medicine, and into the nature and extent of its power over disease -- The philosophy of therapeutics -- Bartlett's other writings -- Elisha Bartlett / TEXTS.
  • A key resource for coaches, scientists and clinicians.
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    A certain sense of self -- Shedding encumbrances -- One of Gall's gals -- Revelations -- Opportunism -- Gold rush -- Entering the fray -- An interlocking system -- Dr. Jekyll or Mr. Hyde? -- Members of a guild -- Citizen scientist -- Political fallout -- "You have to think it's fun" -- Notes -- Bibliography.
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    pt. A. General medicine -- pt. B. Anatomy -- pt. C. Biology, genetics and biochemistry -- pt. D. Therapeutic substances.
  • Bonus Student Consult access - included with the text - allows readers to conveniently access the book's content online. This concise and user-friendly reference provides crucial knowledge for the early years of medical training, as well as for exam preparation.
  • This concise, high-yield title in the popular Integrated Review Series focuses on the core knowledge in genetics while linking that information to related concepts from other basic science disciplines. Case-based questions at the end of each chapter enable you to gauge your mastery of the material, and a color-coded format allows you to quickly find the specific guidance you need. This concise and user-friendly reference provides crucial guidance for the early years of medical training and USMLE preparation. Effectively review for problem-based courses with the help of text boxes that help you clearly see the clinical relevance of the material.
  • This concise, high-yield title in the popular Integrated Review Series focuses on the core knowledge in immunology and microbiology while linking that information to related concepts from other basic science disciplines. Case-based questions at the end of each chapter enable you to gauge your mastery of the material, and a color-coded format allows you to quickly find the specific guidance you need. This concise and user-friendly reference provides crucial guidance for the early years of medical training and USMLE preparation. Effectively review for problem-based courses with the help of text boxes that help you clearly see the clinical relevance of the material.
  • Pharmakokinetics -- Pharmacodynamics and signal transduction -- Toxicology -- Treatment of infectious diseases -- Cancer and immunopharmacology -- Autonomic nervous system -- Hematology -- Cardiovascular system -- Renal system -- Inflammatory disorders -- Gastrointestinal pharmacology -- Endocrine pharmacology -- Central nervous system.
  • Ewing's sarcoma is the second most common malignant bone cancer in children. The prominent defining feature of Ewing's sarcoma is a translocation event between a member of the FET family of RNA binding proteins and a member of the Ets transcription factor family. The majority of patients have a translocation event between the EWSR1 gene and the FLI1 gene. The EWS-FLI1 translocation was first discovered in 1992 and to date, the mechanism by which EWS-FLI1 induces the formation of Ewing's sarcomas remains unclear. Understanding the role of EWS-FLI1 in oncogenesis is critical for Ewing's sarcoma and would have broad implications for other cancers as well. Translocations involving members of the FET or Ets families are also found in leukemia, prostate cancer and other sarcomas. A primary goal of my graduate work has been to develop tools to express EWS-FLI1 in primary human cells as well as in genetically engineered mice to understand how EWS-FLI1 induces oncogenesis and determine the cell of origin in Ewing's sarcoma. As recent work suggested that Ewing's sarcomas arise from a mesenchymal stem/progenitor cell (MSC), we examined the effects of EWS-FLI1 expression in primary human MSCs. We isolated MSCs from pediatric patients at Lucile Packard Children's Hospital to establish human bone marrow derived MSC lines (which we call HBMs). Through a series of experiments, we learned that the precise expression levels of EWS-FLI1 were critical in determining the effect of this oncogene on primary cells. High expression of EWS-FLI1 was not tolerated in HBMs. In contrast, when expressed at lower levels, stable EWS-FLI1 expression was maintained in HBMs. To elucidate transcriptional targets of EWS-FLI1 in HBMs, we used next-generation sequencing (RNAseq) to identify genes dysregulated by EWS-FLI1. Using this approach we identified 170 targets that constitute an EWS-FLI1 expression signature, including novel target genes. Expression of a subset of these genes was dependent on EWS-FLI1 expression in Ewing's sarcoma cell lines, validating their regulation by EWS-FLI1. The majority of these target genes were required for growth in soft agar of Ewing's sarcoma cell lines and some also showed an effect on cell growth. Among these EWS-FLI1 target genes we focused on a novel long non-coding RNA, lnc277, which is induced and regulated by EWS-FLI1 in Ewing's sarcoma cell lines and in other human cell lines ectopically expressing EWS-FLI1. Expression of lnc277 is highly specific to Ewing's sarcoma and is required for cell growth and transformation by EWS-FLI1. To decipher a mechanism for how lnc277 functions in Ewing's sarcoma cells, we have used protein arrays to identify interacting proteins. Lnc277 appears to interact with several proteins involved in transcription, splicing, RNA stability and translation, including STAU1, HNRPK1 and several others. Additionally, we performed RNAseq analysis of lnc277 knock-down to identify specific genes whose expression is altered upon depletion of lnc277. To elucidate the cell of origin for Ewing's sarcoma and create a model that can be used to test novel strategies for treatment, we have genetically engineered mice to conditionally express the EWS-FLI1 translocation from the endogenous EWSR1 locus. We have generated mice that contain lox sites within both the EWSR1 locus and the FLI1 locus such that upon Cre recombinase expression, some cells will undergo a reciprocal recombination event, generating both the EWS-FLI1 and FLI1-EWS chromosomes. We have genomic DNA and mRNA confirmation that this recombination occurs in vitro and in vivo after expression of Cre recombinase. This is the first example to our knowledge of a mouse model that faithfully recapitulates a translocation mechanism in a solid tumor. The reciprocal translocation model relies on two chromosomes recombining with each other, an event that we have found to be highly rare with these two chromosomes in the mouse. Therefore, we focused our efforts on a second mouse model where the recombination event occurs much more efficiently, our EWS-FLI1-V5 mouse model. The EWS-FLI1-V5 mouse model expresses a V5-epitope tagged version of EWS-FLI1 also from the EWSR1 locus. To create this model, a FLI1 cDNA was introduced downstream of the EWSR1 gene on the same chromosome. The expression of Cre recombinase results in the formation of the translocation by splicing the N-terminal EWSR1 exons to a FLI1 cDNA containing the C-terminal exons. This model leads to expression of EWS-FLI1-V5 in the majority of cells where Cre is expressed. We have carried out in vitro studies expressing EWS-FLI1-V5 in mouse embryo fibroblasts (MEFs) and mouse MSCs. Whereas EWS-FLI1-V5 expression inhibits proliferation in MEFs, MSCs expressing EWS-FLI1-V5 continue to proliferate. We have demonstrated that several of the new target genes identified in the human system were also regulated by EWS-FLI1-V5 in mouse cells. We have crossed both our Ewing's sarcoma mouse models to four Cre strains that express Cre recombinase in mesenchymal tissues as well as one that expresses Cre recombinase in the neural crest lineage. Mice from the reciprocal translocation model failed to develop tumors, most likely because the translocation event was so rare either no cell recombined the EWSR1 and FLI1 loci or that EWS-FLI1 expression was not tolerated in the cells that did recombine the loci. The EWS-FLI1-V5 mice expressing EWS-FLI1 in the mesenchymal lineage using Dermo1-Cre, Col1[alpha]2-Cre, Prx1-Cre or Sox9-Cre died embryonically. Interestingly, we only obtained mice that could potentially be expressing EWS-FLI1-V5 in the neural crest lineage using P0-Cre, suggesting the expression of EWS-FLI1-V5 in these cells was not toxic or that other cells can compensate for loss of the cells expressing EWS-FLI1-V5. Whether these adult mice actually express EWS-FLI1-V5 in the tissues derived from the neural crest lineage and whether these mice are tumor prone are areas for future study. Through this thesis work, we have used a combined approach that leverages both human and mouse model systems to create an in vivo model of Ewing's sarcomagenesis. These models could be used to define the cell of origin for Ewing's sarcoma and gain an understanding of the genetic requirements for oncogenesis downstream of EWS-FLI1. Through our studies of pediatric human mesenchymal stem cells expressing EWS-FLI1 in Chapters 2 and 3, we have discovered a number of novel EWS-FLI1 target genes and identified a lncRNA that is highly specific to and required for EWS-FLI1 mediated oncogenesis. In Chapters 4 and 5, two novel transgenic mouse strains were generated to express the EWS-FLI1 gene fusion from the endogenous EWSR1 locus in a way that is physiologically relevant to Ewing's sarcoma. These tools should help define the effects of EWS-FLI1 expression in primary and cancer cells and hopefully result in new therapies to benefit children diagnosed with this disease.
  • The genome is under constant threat by DNA damage arising from endogenous and exogenous sources, and it is particularly susceptible to damage during DNA replication. Using a genome-wide siRNA screen to identify proteins necessary for genome maintenance in the presence of replication stress, we identified NEK8/NPHP9, a ciliary protein kinase associated with two renal ciliopathies in humans and mice, nephronophthisis (NPHP) and polycystic kidney disease (PKD). Renal ciliopathies are a leading cause of kidney failure, but their exact etiology is poorly understood. Recent findings have shown that several genes linked to the DNA damage signaling are mutated in patients with NPHP or NPHP-like diseases. However, whether loss of the DNA damage response (DDR) itself played a causal role in NPHP is not clear, and the underlying mechanism linking these genes to NPHP is not addressed. This thesis work provides new mechanistic insight into the functions of the NIMA-related kinase, NEK8, in suppressing DNA damage arising from replication stress, and for the first time connects the replication stress response to cystic kidney diseases and renal ciliopathies. Here we directly demonstrate that replication stress, caused by the DNA polymerase inhibitor aphidicolin, as well as NEK8 loss, affects renal cell architecture in a 3D-culture system. Moreover, NEK8 mutation leads to replication stress and DNA damage in the pre-cystic kidney. We further establish that NEK8 is a crucial effector of the replication stress response and that it functions as part of the ATR-dependent signaling pathway, regulating replication fork dynamics and fork stability through effects on CDK activity. We also show NEK8's role in the replication stress response is compromised by ciliopathy-causing mutations. Thus, our study strongly suggests that excessive replication stress or a defect in the ability of cells to respond to replication stress leads to chronic damage in renal epithelial cells and kidney failure in ciliopathies. The major contributions of this dissertation are: (1) We validated NEK8 as a high confidence hit from a previously described unbiased siRNA screen designed to uncover genes that help maintain genome stability during DNA replication stress. (2) Cells lacking NEK8 form spontaneous DNA double-strand breaks (DSBs) which further accumulate when replication forks stall. (3) NEK8 acts at the replication fork to regulate fork dynamics and replication origin firing, particularly under conditions of replication stress. (4) NEK8 functions in the ATR pathway, interacting with ATR and other components of the replication checkpoint, and it suppresses S-phase CDK activity during replication to prevent premature origin firing. (5) NEK8 mutations, which produce kinase-inactive protein or juvenile cystic kidneys (jck), abolish the interaction of NEK8 with ATR and fail to prevent DNA damage accumulation in NEK8-deficient cells. (6) Disruption of NEK8, as well as replication stress induced by aphidicolin, perturbs both ciliogenesis and spheroid structure in a 3D assay that models renal kidney architecture and NPHP. This study therefore provides the first direct evidence that replication stress contributes to renal ciliopathies and mechanistic insight into how it does so. Furthermore, it identifies a new critical component of the replication stress response: NEK8.
  • The ubiquitous parasite Toxoplasma gondii has developed an exquisite arsenal of effectors to support its intracellular lifestyle and its persistence within its diverse hosts. In order to survive and resist clearance, this obligate intracellular parasite must contend with the host immune response. Different strains of the parasite vary dramatically in their interaction with the immune system, and studying these strain differences has furthered our understanding of the spectrum of host-pathogen interactions and led to the identification of parasite effectors. The work described here dissects the interactions between different strains of the parasite and host macrophages: innate immune cells that paradoxically both serve as a niche for parasite replication and defend the host against parasite infection. Chapter 1 introduces Toxoplasma, the immune response to infection, and discusses the role of known parasite effectors. Experiments described in Chapter 2 identify a novel secreted parasite factor, GRA25, which modulates cytokine secretion in macrophages and controls parasite virulence in mice. In Chapter 3, high throughput methods are used to characterize the transcriptional and phosphorylation landscape of macrophages infected with different Toxoplasma strains. These analyses demonstrate that a secreted polymorphic tyrosine kinase, ROP16, directs murine macrophage polarization towards an alternatively activated phenotype. They also reveal that Toxoplasma parasites activate the Type I interferon response, a response classically associated with cytosolic pathogens. Chapter 4 describes work demonstrating that Toxoplasma strain-specifically modulates the innate immune response via secretion of a parasite factor, MAF1, which recruits host mitochondria to the parasitophorous vacuole. Finally, Chapter 5 discusses the future directions and implications of this work in the broader context of host-pathogen interactions.
  • "Completely updated and expanded, 'Emans, Laufer, and Goldstein's Pediatric and Adolescent Gynecology', Sixth Edition, covers the medical and surgical approaches to common pediatric and adolescent clinical problems. The book discusses the importance of the history and physical examination and the physiology of puberty and its associated disorders and complications"--Provided by publisher.
  • Features of embitterment -- Embitterment -- a larger perspective on a forgotten emotion / Hansjö̲rg Znoj -- Hope and embitterment / Beate Schrank, Astrid Grant Hay -- Embitterment -- from the perspective of justice psychology / Claudia Dalbert -- Revenge after trauma; theoretical outline / Ira Gäbler, Andreas Maercker -- "She looks back without bitterness": Wisdom as a developmental opposite of embitterment / Judith Glück -- Personality as risk and resilience in embitterment reactions / Anja Dodek, Sven Barnow -- Neurobiological correlates of social exclusion and social pain / Anna K. Berkefeld, Dieter F. Brauss -- Context of embitterment -- Relationships and embitterment / Kurt Hahlweg, Donald H. Baucom -- Self-regulation of bitterness across the lifespan / Carsten Wrosch, Jesse Renaud -- Cancer patients: loss of meaning, demoralization and embitterment / Anja Mehnert, Sigrun Vehling -- Embitterment and the workplace / Beate Muschalla, Michael Linden -- Embittermenta in Asia: losing face, inequality and alienation under historical and modern perspectives / Changsu Han -- Embitterment and personality disorder / Max Rotter -- Context of embitterment -- Embitterment syndrome: options for psychopharmacological management / Borwin Bandelow -- Forgiveness therapy to treat embitterment: a review of relevant research / Nathaniel G. Wade, Brian C. Post, Marilyn A. Cornish -- Wisdom psychotherapy / Barbara Lieberei, Michael LInden -- Embitterment and forgiveness in the context of the conflict in Northern Ireland / Ed Cairns, Miles Hewstone -- Classification of embitterment -- PTSD and beyond: embitterment and relevant concepts of nosology / Andreas Maercker -- Embitterment in suicide and homicide-sucide / Kenneth R. Conner, Robert L. Weisman -- Should embitterment be included among mental disorders? / Norman Sartorius -- Posttraumatic embitterment disorder, PTED / Michael Linden -- Classification of "reactive" mental disorders in ICD and DSM / Michael B. First -- Contextual facators and reacative disorders in the International Classification of Functioning, Disability and Health / Cille Kennedy, T. Bedirhan Üstün -- Reactive mental disorders: stressors, personality and symptoms / Patricia Casey.
  • Also available: Print – 2005
  • Embolisation 2012
  • Embolization 2014
    Innovations in catheterization techniques and embolization agents have considerably contributed to the development of endovascular occlusion techniques in arterial and venous trunks as much as distal parenchymal capillar beds. Mini invasive therapies, endovascular embolization and chemo-embolization now constitute valuable therapeutic alternatives in various fields: on a purely palliative or on a curative basis in oncology, but also in traumatology, functional diseases, and for the treatment of benign tumors, or when dealing with post-operative complications. As in-depth and detailed descriptions of these techniques are all ready available in specialized books, our ambition is to provide a basic handbook for the young vascular radiologists in training and a checklist for the more experienced interventional radiologists, by providing for each of the constantly increasing indications a synthetic approach of the technique and its expected results. The first part of this book relates to the tool box (the materials) and the procedure techniques as well as the physiopathological requirements for carrying out embolization; the second part is an analytical description of the main situations and anatomo-clinical strategies. This handy book should to be a valuable memory aid for clinicians and interventional radiologists, readily available in the multidisciplinary staff rooms and in angiography suites.
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    How does an embryo form? -- How do the placenta and fetal membranes form? -- The body cavities and the diaphragm -- The integumentary, skeletal, and muscular systems -- The respiratory system -- The cardiovascular system -- The digestive system -- The urinary system -- The reproductive system -- The nervous system -- Development of the head and neck, the eye, and the ear.
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  • Immune privilege of stem cells / Naoki Ichiryu and Paul J. Fairchild -- Immunogenicity of in vitro maintained and matured populations : potential barriers to engraftment of human pluripotent stem cell derivatives / Chad Tang, Irving L. Weissman, and Micha Drukker -- Hematopoietic and nature killer cell development from human pluripotent stem cells / Zhenya Ni, David A. Knorr, and Dan S. Kaufman -- Evaluation of immunogenicity of rat ES-cell derived endothelial cells / Martina Seifert and Juliane Ladhoff -- Interaction of ES cell derived neural progenitor cells with natural killer cells and cytotoxic T cells / Casimir de Rham and Jean Villard -- Strategies to generate induced pluripotent stem cells / Michael Hayes and Nicholas Zavazava -- Differentiation and lineage commitment of murine embryonic stem cells into insulin producing cells / Sudhanshu P. Raikwar and Nicholas Zavazava -- Mouse ES cell-derived hematopoietic progenitor cells / Eun-Mi Kim, Gohar Manzar, and Nicholas Zavazava -- Directed differentiation of embryonic stem cells to the T-lymphocyte lineage / Haydn C.-Y. Liang, Roxanne Holmes, and Juan Carlos Zúñiga-Pflücker -- Development of hematopoietic stem and progenitor cells from mouse embryonic stem cells, in vitro, supported by ectopic human HOXB4 expression / Sandra Pilat, Sebastian Carotta, and Hannes Klump -- Histone modification profiling in normal and transformed human embryonic stem cells using micro chromatin immunoprecipitation, scalable to genome-wide microarray analyses / Angelique Schnerch, Shravanti Rampalii, and Mickie Bhatia -- Combined total proteomic and phosphoproteomic analysis of human pluripotent stem cells / Junjie Hou ... [et al.] -- Transcriptional regulatory mechanisms that govern embryonic stem cell fate / Satyabrata Das and Dana Levasseur.
  • Embryonic stem cell protocols. 2nd ed. v. 1-2, 2006
    Springer Protocols
    v. 2, 2006 Springer Protocols
    v. 1. Isolation and characterization -- v. 2. Differentiation models.
  • Embryonic stem cells 2006
    Also available: Print – 2006
    Derivation and maintenance of embryonic stem cells -- Differentiation of embryonic stem cells.
  • Defined culture media for human embryonic stem cells / T. Ludwig and J. Thomson -- Generation of disease-specific human embryonic stem cell lines / S. Minger -- Characterization and differentiation of human embryonic stem cells / A. Laslett ... [et al.] -- Genetic modification of human embryonic stem cells / T. Zwaka -- Hematopoietic differentiation / C. Cerdan ... [et al.] -- Neural differentiation / Z.-J. Zhang ... [et al.] -- Germ cell differentiation / V. Angeles and R. Pera -- Mesodermal differentiation / N. Sharon and N. Benvenisty -- Three-dimensional culture of human embryonic stem cells / S. Gerecht ... [et al.] -- Extraembryonic cell differentiation / L. Armstrong and M. Lako -- Pancreatic cell differentiation / B. Fishman ... [et al.] -- Cardiomyocyte differentiation / D. Singla ... [et al.] -- Human embryonal carcinoma (EC) cells: Complementary tools for embryonic stem cell research / P. Tonge and P. Andrews -- Quality control of human stem cell lines / G. Stacey.
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    Procedures for deriving ES cell lines from the mouse / Frances A. Brook -- Production of ES cell-derived mice / Yoko Kato and Yukio Tsunoda -- Generating animal models of human mitochondrial genetic disease using mouse ES cells / Grant R. MacGregor ... [et al.] -- Controlling the differentiation of mouse ES cells in vitro / Michael V. Wiles and Gabriele Proetzel -- In vitro differentiation of mouse ES cells into muscle cells / Yelena S. Tarasova [et al.] -- In vitro differentiation of mouse ES cells into haematopoietic cells / Osamu Ohneda and Masayuki Yamamoto -- Lineage selection and transplantation of mouse ES cell-derived neural precursors / Tanja Schmandt, Tamara Glaser and Oliver Brüstle -- In vitro differentiation of mouse ES cells into pancreatic and hepatic cells / Przemyslaw Blyszczuk, Gabriela Kania and Anna M. Wobus -- Isolation and characterization of human ES cells / Martin F. Pera -- Differentiation of human ES cells / Sharon Gerecht-Nir and Joseph Itskovitz-Eldor -- ES cell lines from the cynomolgus monkey (Macaca fascicularis) / Hirofumi Suemori [et al.].
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    The relationship between genotype and phenotype : some basic concepts / Philip Stanier and Gudrun Moore -- Uses of databases in dysmorphology / Michael Baraitser -- Human cytogenetics / J.D.A. Delhanty -- Identification and analysis of genes involved in congenital malformation syndromes / Peter J. Scambler -- Transgenic technology and its role in understanding normal and abnormal mammalian development / Valerie Vidal and Andreas Schedl -- Chemical teratogens : hazards, tools, and clues / Nigel A. Brown -- The limbs / Patrizia Ferretti and Cheryll Tickle -- Brain and spinal cord / Andrew J. Copp -- Birth defects affecting the eye / Jane C. Sowden -- The ear / Sarah L. Spiden and Karen P. Steel -- Development of the enteric nervous system in relation to Hirschsprung's Disease / Heather M. Young, Donald F. Newgreen and Alan J. Burns -- The head / Gillian M. Morriss-Kay -- The heart / Deborah Henderson, Mary R. Hutson and Margaret L. Kirby -- The skin / Ahmad Waseem and Irene M. Leigh -- The vertebral column / David Rice and Susanne Dietrich -- The kidney / Paul J.D. Winyard -- The teeth / Irma Thesleff.
  • This comprehensive guide answers commonly asked questions about neurosurgical conditions related to brain and spinal cord. Emergency Approaches to Neurosurgical Conditions fills the gap which arises after a diagnosis is made on the loved one, explaining the basics of neurosurgical diseases and their management. Emergency Approaches to Neurosurgical Conditions concentrates on the brain and spine, both in surgery and radiotherapy, as well as congenital and accident-related conditions. This comprehensive book which is part of a book-set including Comprehensive Guide to Neurosurgical Conditions, informs the reader on various symptoms to look for, and helps with the management of brain and spine surgery in chapters written by reputed neurosurgeons to help the physicians, the patients and their families.
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  • Introduction to emergency imaging -- Brain -- Head and neck -- Spine -- Chest -- Abdomen and pelvis -- Musculoskeletal -- Pediatrics.
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    Section I. Resuscitation skills and techniques -- Section II. Special considerations in the pediatric patient -- Section III. Head and neck injuries -- Section IV. Gastrointestinal diseases -- Section V. Pulmonary diseases -- Section VI. Cardiac diseases -- Section VII. Vascular diseases -- Section VIII. Injuries to bones and organs -- Section IX. Neurologic diseases -- Section X. Allergic inflammatory, and autoimmune disorders -- Section XI. Genitourinary and renal diseases -- Section XII. Women's health and gynecologic diseases -- Section XIII. Environmental injuries -- Section XIV. Toxicologic emergencies -- Section XV. Bites, stings, and injuries from animals -- Section XVI. Metabolic and endocrine disorders -- Section XVII. Infections -- Section XVIII. Wounds and skin injuries -- Section XIX. Rashes -- Section XX. Emergency psychiatric disorders -- Section XXI. Hematology and oncology management -- Section XXII. Leadership, communication, and administration -- Index.
  • Be prepared to manage increasingly prevalent problems seen in the ED, such as emergent complications of fertility treatment and management of patients who have had bariatric surgery. Deliver high-quality care to your younger patients with expanded pediatrics content. Stay up to date with new chapters on Clotting Disorders and Hemophilia, Patient-Centered Care, Health Disparities and Diversity in Emergency Medicine, Cost-Effectiveness Analysis, Antibiotic Recommendations for Empirical Treatment of Selected Infectious Diseases, and Cardiac Emergency Ultrasound: Evaluation for Pericardial Effusion & Cardiac Activity.
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    Resuscitation -- Cardiovascular emergencies -- Pulmonary emergencies -- Gastrointestinal emergencies -- Urogenital emergencies -- Infectious disease emergencies -- Metabolic emergencies -- Endocrine emergencies -- Neurologic emergencies -- Rheumatologic and allergic emergencies -- Dermatologic emergencies -- Eye, ear, nose, throat, and dental emergencies -- Psychiatric emergencies -- Obstetric and gynecologic emergencies -- Pediatric emergencies -- Hematologic and oncologic emergencies -- Trauma emergencies -- Orthopedic emergencies -- Wound emergencies -- Toxicologic emergencies -- Environmental emergencies -- Emergency medical services -- Disaster medicine -- Legal issues.
  • Emergency medicine-- PreTest self-assessment and review. 3rd ed. 2012
    AccessEmergency Medicine, Users must register and sign in to take a test
    Also available: Print – 2012
    Chest Pain and Cardiac Dysrhythmias -- Shortness of Breath -- Abdominal and Pelvic Pain -- Trauma, Shock and Resuscitation -- Fever -- Poisoning and Overdose -- Altered Mental Status -- Gastrointestinal Bleeding -- Musculoskeletal Injuries -- Headache, Weakness, and Dizziness -- Pediatrics -- Vaginal Bleeding -- Ultrasound in the Emergency Department -- Environmental Exposures -- Eye Pain and Visual Change -- Wound Care -- Prehospital, Disaster, Administration -- Endocrine Emergencies -- Psychosocial Disorders.
  • Emergency medicine procedures. 2nd ed. 2015
    AccessEmergency Medicine
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  • "This book is written and designed to provide medical educators in emergency medicine with resource for integrating medical simulation into their teaching practices. Material is provided in the form of clinical cases which are drawn from a diverse group of faculty authors from a range of major teaching centers. The cases provide readers with a full spectrum of pathology. Moreover, each case is formatted and annotated so that it can be tailored to novice or advanced learners, and easily deployed in a diversity of settings. Valuable "tips or tricks" accompany images patient data. Overall, this book is deal for use by EM educators as part of a tailored teaching and assessment portfolio"--Provided by publisher.
  • This book is a practical guide to the radiologic evaluation of acute musculoskeletal injuries of the upper and lower extremities in children. It covers the detection of more subtle and frequently missed fractures and injuries such as buckle fractures, Salter Harris I and II fractures, and epiphyseal and metaphyseal fractures. It also emphasizes the assessment of soft tissues and periarticular fat pads, which can lead to discovery of the sites of bony injuries. Other pathologies that affect the musculoskeletal system, such as infections and tumors, are also discussed. It includes over 600 magnetic resonance, computed tomography, ultrasound, and radiographic images organized by anatomic region.
  • Emergency neurology 2012
    1. Headache in the Emergency Department / Carrie E. Robertson, David F. Black and Jerry W. Swanson -- 2. Low Back Pain Emergencies / Luis A. Serrano, Tim Maus and J.D. Bartleson -- 3. Dizziness and Vertigo Presentations in the Emergency Department / Kevin A. Kerber and Robert W. Baloh -- 4. Syncope / Mark D. Carlson -- 5. Acute Visual Loss / Cédric Lamirel, Nancy J. Newman and Valérie Biousse -- 6. Diplopia, Third Nerve Palsies, and Sixth Nerve Palsies / Janet C. Rucker -- 7. Facial Nerve Palsy / James M. Gilchrist -- 8. Acute Stroke Evaluation and Management / Ty Tiesong Shang, Dileep R. Yavagal, Jose G. Romano and Ralph L. Sacco -- 9. Intracerebral Hemorrhage / Pratik Vishnu Patel, Lucas Elijovich and J. Claude Hemphill -- 10. Seizures and Status Epilepticus / Sandipan Pati and Joseph I. Sirven -- 11. Central Nervous System Infections / Karen L. Roos -- 12. Weakness (Guillain-Barré Syndrome) / Mengjing Huan and A. Gordon Smith -- 13. Spinal Cord Compression and Myelopathies / William F. Schmalstieg and Brian G. Weinshenker -- 14. Movement Disorder Emergencies / Robert L. Rodnitzky -- 15. Encephalopathy / Steven L. Lewis -- 16. Acute Respiratory Failure in Neuromuscular Disorders / Cynthia L. Bodkin and Robert M. Pascuzzi -- 17. Coma and Brain Death / Robert E. Hoesch and Romergryko G. Geocadin -- 18. Neurotoxicology Emergencies / Laura M. Tormoehlen -- 19. Substance Abuse, Somatization, and Personality Disorders / Ronald Kanner.
  • Emergency Orthopedics is a practical, up-to-date, and comprehensive manual on the diagnosis and treatment of emergency injuries and disorders of the locomotor system. Its problem-based structure, with each chapter addressing a particular symptom, is designed to allow the reader to rapidly locate hands-on advice. For each symptom, facts and findings that will assist in diagnosis are highlighted. Possible diagnoses are suggested according to the ICD-10 code, and the proposed treatment recommendations consider both short- and long-term aspects. The text is supported by exceptionally instructive illustrations, e.g., of examination techniques and reduction maneuvers. The author has extensive practical experience in emergency rooms as well as in sports medicine, research, and education. This book will be a treasure trove of information for all who work in the emergency room and will also be very useful for general practitioners, physiotherapists, and chiropractors.
  • Imaging of Acute Aortic Conditions -- Emergencies of the Biliary Tract -- Acute Appendicitis -- Imaging of Small Bowel -- Imaging of Bowel Obstruction -- Imaging of Acute Colonic Disorders -- Imaging of Genitourinary Emergencies -- Imaging of Acute Conditions of Male Reproductive Organs -- Imaging of Blunt and Penetrating Abdominal Trauma -- Acute Nontraumatic Imaging in the Liver and Spleen -- Imaging of Acute Pancreas -- Imaging of Acute Obstetric Disorders -- Imaging of Acute Gynecologic Disorders -- Emergency Radionuclide Imaging of the Thorax and Abdomen -- Imaging of Neck Emergencies -- Imaging of Acute Head Emergencies -- Imaging of Facial Fractures -- Stroke and Its Imaging Evaluation -- Imaging of Acute Orbital Pathologies -- Imaging of Upper Extremity -- Lower Extremity Trauma -- Imaging of Spinal Trauma -- Imaging of Nontraumatic Mediastinal and Pulmonary Processes -- Imaging of Acute Thoracic Trauma -- Imaging of Lines and Tubes -- Imaging of Pediatric Emergencies.
  • Opening Round -- Fair Game -- Challenge.
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  • Emergency radiology-- case studies 2015
    AccessEmergency Medicine
    Text is specifically designed to help fine-tune emergency radiographic interpretation and problem-solving abilities. Illustrated with hundreds of high-resolution images, this reference covers the full range of clinical problems in which radiographic studies play a key role. Tha author takes you step-by-step through the radiographic analysis of medical, surgical, and traumatic disorders, giving you an unparalleled review of the use and interpretation of radiographic studies in emergency diagnosis.
  • The term "acute abdomen" refers to a serious, often progressive clinical situation that calls for immediate diagnostic and therapeutic action. Today, diagnosis via imaging has basically replaced the physical examination in the emergency room and the Radiologist has become of primary importance in this setting. However, close co-operation among the various specialists involved is essential for successful patient management, and thus the Radiologist needs to have a full understanding of the imaging modalities and technical skills required, as well as appropriate clinical knowledge of t
  • The Requisites series for studying and rotation preparation presents this essential text on emergency radiology. It provides the foundation and the heart of the information you need for the Board exam and every day clinical use. With key features like emergent findings tables and differential diagnoses tables plus 600 high-quality images, this book makes it easy to review important information. Experts on various body systems and modalities of emergency radiology bring you a concise reference that meets all of your study needs.
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  • Also available: Print – 2006
  • Global effects and prevention of emerging and epidemic pathogens: cholera and citrus greening as examples -- Surveillance -- Epidemiological surveillance of highly pathogenic diseases in Kazakhstan -- Surveillance on plague in Natural foci in Georgia -- Application of modern techniques for studying bacterial pathogens in Georgia -- Especially dangerous infections in Azerbaijan -- Strengthening the early-warning function of the surveillance system: the Macedonian experience -- Integrating geographic information systems and ecological niche modeling into disease ecology: a case study of Bacillus anthracis in the United States and Mexico -- Molecular analysis and tools -- Applications of paleomicrobiology to the understanding of emerging and re-emerging infectious diseases -- Characterization of a putative hemagglutinin gene in the caprine model for brucellosis -- Pathoadaptation of especially dangerous pathogens -- Detection of pathogens via high-throughput sequencing -- Environmental infuences on the relative stability of baculoviruses and Vaccinia virus: a review.
  • The role of HLA in MS susceptibility and phenotype -- Sex-based differences in multiple sclerosis (Part I): biology of disease incidence -- Sex-based difference in multiple sclerosis (MS): Part II: rising incidence of multiple sclerosis in women and the vulnerability of men to progression of this disease -- The role of environment and lifestyle in determining the risk of multiple sclerosis -- Evidence for an association between Vitamin D and multiple sclerosis -- Photoimmunology and multiple sclerosis -- Modelling MS: chronic-relapsing EAE in the NOD/Lt mouse strain -- Developing biomarkers for MS -- Helminth Therapy for MS -- Self-assembling peptides form immune suppressive amyloid fibrils effective in autoimmune encephalomyelitis -- Index.
  • Emerging applications of colloidal noble metals in cancer nanomedicine / Jian Zhang & Joseph R. Lakowicz -- Particle characterizations and synthesis methods / Jian Zhang & Joseph R. Lakowicz -- Diagnostics and treatments / Anna M. Sitarski, Jeremy L. Grant, Sanjeev Kumar Kandpal & Michael D. Mason -- Photothermal agents for cell theranostics / Dmitri O. Lapotko -- Drug delivery carriers / Marie-Christine Daniel -- Other applications and future directions / Ismail Ocsoy, Tao Chen & Weihong Tan -- Applications of noble metal nanoparticles in fluorescence sensing / Yi Fu -- Index.
  • Ch. 1. Quantitative radiology: applications to oncology -- Ch. 2. The intricate role of CXCR4 in cancer -- Ch. 3. Recent advances in nanoparticle-based nuclear imaging of cancers -- Ch. 4. Molecular-genetic imaging of cancer -- Ch. 5. Real-time fluorescence image-guided oncologic surgery -- Ch. 6. Cerenkov Imaging -- Ch. 7. Molecular imaging of the tumor microenvironment for precision medicine and theranostics -- Ch. 8. Tracking cellular and immune therapies in cancer -- Ch. 9. Developing MR probes for molecular imaging -- Ch. 10. Clinical translation of molecular imaging agents used in PET studies in cancer -- Index.
  • Neuro-oncology is one of the most exciting and rapidly evolving areas of oncology. In recent years there has been a remarkable increase in activity in the field, from basic science through to the clinic. This is reflected by advances in the understanding of the biology of CNS malignancies which have informed the development of novel and successful therapies. In this environment it is essential to facilitate communication and understanding of new ideas and concepts. Emerging Concepts in Neuro-Oncology is written with this in mind: to encourage collaboration across traditional boundaries and promote translational research for patient benefit. The book moves from concepts in the scientific basis of neuro-oncology in part one, through models of brain cancer in part two, to emerging concepts in clinical practice in part three, with a focus on translational research. This book will be an essential read for neuroscience researchers, cancer researchers, neurosurgeons and clinical oncologists as well as anyone with an interest in this exciting, dynamic field.
  • A global perspective on the management and prevention of emerging and re-emerging diseases Emerging infectious diseases are newly identified or otherwise previously unknown infections that cause public health challenges. Re-emerging infectious diseases are due to both the reappearance of and an increase in the number of infections from a disease that is known, but which had formerly caused so few infections that it was no longer considered a public health problem. The factors that cause the emergence or re-emergence of a disease are diverse. This book takes a look at the worl
  • pt. 1. Identifying emerging pathogens -- pt. 2. Individual pathogens.
  • Store-operated calcium (SOC) entry and channel play a central role in regulating intracellular calcium concentrations in a variety of cell types. SOC is critical for many physiological processes, most notably activation of the immune system, where its lack of function is known to cause severe combined immunodeficiency (SCID) in human patients. In lymphocytes, where SOC has been extensively studied, it has been shown that SOC is mediated by the calcium channel Orai that is activated by its direct binding to STIM, a calcium sensor localized in the endoplasmic reticulum. While it was previously thought that SOC serves an important role only in immune and non-excitable cells, it is now clear that SOC and the proteins that regulate its function are ubiquitously expressed in variety of tissues, including muscle and the nervous system, and serve a diverse set of biological functions. More recently, SOC has been shown to act in a several pathological processes, ranging from muscular dystrophy to cancer, underscoring the significance of gaining a better understanding of its mechanism of action. Here we set out to develop pharmacological blockers of SOC, in order to gain insights into its molecular mechanism and physiological role. Such blockers could allow for acute inhibition of SOC, allowing for a temporal control that is essential for mechanistic studies. If successfully developed, such reagents could also be of therapeutic use as immunosuppressants or anti thrombotic agents in human patients. We designed a novel methodology for generating SOC blockers based on the identification and targeting of minimal functional domains (MFDs) of STIM and Orai. Using this approach, we identified small molecule blockers that can inhibit SOC at high nanomolar concentrations and can also block T cell activation in vitro and in vivo. These studies not only provide an important set of tools for better understanding STIM and Orai function, but also identify compounds that could potentially be developed into therapeutic agents for the treatment of pathological conditions such as autoimmune disease.
  • Emerging oral medications for multiple sclerosis / Sten Fredrikson & Jan Hillert -- Unmet medical needs with current standard treatments / Fredrik Piehl -- Potential drug targets for oral medications / Felix Luessi & Frauke Zipp -- Oral agents for the treatment of RR-MS / Douglas R. Jeffery -- Other therapeutics in the pipeline and future directions / Yuval Karmon, Bijal Mehta & Bianca Weinstock-Guttman -- Index.
  • 1. Introduction -- 2. Investigative Toxicology: The State of the Art -- 3. Screening Technologies I: Human Cell-Based Approaches -- 4. Screening Technologies II: Toxicogenomics -- 5. Screening Technologies III: Metabolomics -- 6. Screening Technologies IV: Pharmacogenetics -- 7. Qualifying Biomarkers -- 8. Pharmacovigilance -- 9. Integration -- 10. The Future of Safety Science.
  • Global changes in diet and activity patterns as drivers of the nutrition transition / Popkin, B.M. -- Regional case studies : India / Reddy, K.S. -- Regional case studies : China / Yin, S. -- Regional case studies : Africa / Prentice, A.M. -- Obesity in emerging nations : evolutionary origins and the impact of a rapid nutrition transition / Prentice, A.M. -- Prenatal origins of undernutrition / Christian, P. -- Postnatal origins of undernutrition / Prost, M.-A. -- Malnutrition, long-term health, and the effect of nutritional recovery / Sawaya, A.L. ... [et al.] -- The role of epigenetics in mediating environmental effects on phenotype / Morgan, D.; Whitelaw, E. -- Metabolism of methionine in vivo : impact of pregnancy, protein restriction, and fatty liver disease / Kalhan, S.C. -- Adiposity and comorbidities : favorable impact of caloric restriction / Ravussin, E.; Redman, L.M. -- Obesity, inflammation, and macrophages / Subramanian, V.; Ferrante, A.W., Jr. -- Obesity, hepatic metabolism and disease / Edmison, J.M.; Kalhan, S.C.; McCullough, A.J. -- Imperative of preventive measures addressing the life-cycle / Yajnik, C.S. -- New approaches to optimizing early diets / Polberger, S. -- Prevention of low birthweight / Alam, D.S. -- Community-based approaches to address childhood undernutrition and obesity in developing countries / Shetty, P.
  • Hepatitis C virus infection : from discovery to eradication / Masao Omata & Tatsuo Kanda -- Interferons in clinical trials / Tatsuo Kanda, Osamu Yokosuka & Masao Omata -- Protease inhibitors / Marion Corouge, Philippe Sogni & Stanislas Pol -- NS5A inhibitor : daclatasvir / Kazuaki Chayama & C. Nelson Hayes -- Toll-like receptor agonists for nonresponders to HCV treatment : hope versus promise? / Valérie Martel-Laferrière & Douglas Dieterich -- Treatment options in HIV-HCV-coinfected patients / Philippe Sogni, Marion Corouge & Stanislas Pol -- Treatment options for dual HCV/HBV coinfection / Chun-Jen Liu & Jia-Horng Kao -- HCV treatment in patients with metabolic syndrome / Luigi E. Adinolfi, Rosa Zampino, Luciano Restivo, Amedeo Lonardo & Paola Loria -- Future directions in hepatitis C therapy / Stevan A. Gonzalez -- Index.
  • Systemic Therapy for Ovarian Cancer, Current Treatment, Recent Advances, and Unmet Needs / Susana Banerjee, Michael A. Bookman, and Martin Gore -- Discovery of Novel Targets / John Farley and Michael J. Birrer -- Novel Anti-angiogenic Therapies in Ovarian Cancer / Jurjees Hasan and Gordon Jayson -- Targeting the AKT Pathway in Ovarian Cancer / Euan A. Stronach ... [et al.] -- Inhibition of the Src Oncogene : Therapeutic Potential in Ovarian Carcinoma / Liz Y. Han and Anil K. Sood -- Tumour-Specific Synthetic Lethality : Targeting BRCA Dysfunction in Ovarian Cancer / Timothy A. Yap ... [et al.] -- Targeting Inflammatory Pathways in Epithelial Ovarian Cancer / Jermaine Coward and Frances Balkwill -- Epithelial-to-Mesenchymal Transition and Cellular Membrane Receptors in Ovarian Cancer : Moving Forward in the Era of Molecularly Targeted Therapy / Lainie P. Martin, Julia J. Perkins, and Russell J. Schilder -- Epigenetic Therapies / Robert Brown, Nadine Chapman-Rothe, and Ros Glasspool -- Ovarian Cancer Immunology and Immunotherapy / Sadaf Ghaem-Maghami and Martin Gore -- Ovarian Cancer Progenitor/Stem Cells: Therapeutic Potential / Susan K. Murphy and Andrew Berchuck -- Potential for α-Folate Receptor-Targeted Treatment for Ovarian Cancer / Chau H.M. Ng and Ann L. Jackman -- New Insights into Tubulin Binders / Carles Escriu and James D. Brenton.
  • Emerging therapeutics for melanoma / Francesco M. Marincola, Paolo Ascierto & John M. Kirkwood -- Melanoma pathophysiology and drug targets / Giuseppe Palmieri, Carla Rozzo, Giusy Gentilcore & Paolo Antonio Ascierto -- Melanoma classification, diagnosis and staging / Mohammed Kashani-Sabet -- Melanoma prevention / Pamela B. Cassidy, Douglas Grossman & Sancy A. Leachman -- Surgical treatment of melanoma : from excision to sentinel node biopsy / Nicola Mozzillo & Corrado Caracò -- Adjuvant therapy in melanoma / Diwakar Davar, Ahmad A. Tarhini & John M. Kirkwood -- Immunostimulatory monoclonal antibodies for melanoma treatment / Miguel Fernandez de Sanmamed, Jose L. Perez-Gracia, Salvador Martín-Algarra & Ignacio Melero -- New signal transduction inhibitors / Keith T. Flaherty -- Melanoma vaccines in development / Ruggero Ridolfi, Laura Ridolfi, Stefania V.L. Nicoletti & Massimo Guidoboni -- Melanoma and biomarkers of immunoresponsiveness : predicting the clinical outcome of immunotherapy / Davide Bedognetti, Ena Wang, Mario Roberto Sertoli & Francesco M. Marincola -- Uveal melanoma / Paola Queirolo, Graziano Caltabiano & Francesco Spagnolo -- Management of melanoma brain metastases in the era of targeted therapies / Daniela Gonsalves Shapiro, Michael T. Shapiro & Wolfram E. Samlowski -- Which therapy for which patient? / Antoni Ribas -- Index.
  • The Singapore contribution in the battle against the severe acute respiratory syndrome / Fielding, B.C., Tan, Y.-J. -- Avian influenza in Thailand / Puthavathana, P. ... [et al.] -- Emerging viral diseases of fish and shrimp / Wang, M. ... [et al.] -- Avian influenza H5N1 virus: an emerging global pandemic / Lal, S.K., Chow, V.T.K. -- Henipaviruses: new threats for Southeast Asia and Australia / McCormack, J., Smith, G. -- Ross River virus: an arthritogenic alphavirus of significant importance in the Asia Pacific / Tupanceska, D. ... [et al.] -- Emerging and re-emerging infectious diseases in our global village / Heymann, D.L. -- Role of a pathology laboratory in SARS and other emerging infections / Nicholls, J., Peiris, J.S.M. -- The fight against emerging viral diseases in Asia / Lam, S.K.
  • 2013 ClinicalKey
    For decades, Emery & Rimoin's Principles and Practice of Medical Genetics has provided the ultimate source for practicing clinicians to learn how the study of genetics can be integrated into practice. With advances in high-throughput technologies propelling the closer integration of lab and clinical work, this sixth edition bridges the gap between high-level molecular genetics and individual application. This comprehensive yet practical resource emphasizes theory and research fundamentals related to applications of medical genetics across the full spectrum of inherited disorders.
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  • Master the genetics you need to know with the updated 14th Edition, by Drs. Peter Turnpenny and Sian Ellard. Review the field's latest and most important topics with user-friendly coverage designed to help you better understand and apply the basic principles of genetics to clinical situations. Learning is easy with the aid of clear, full-color illustrative diagrams, a wealth of clinical photographs of genetic diseases, multiple-choice and case-based review questions, end-of-chapter summaries, and convenient.
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    The history and impact of genetics in medicine -- The cellular and molecular basis of inheritance -- Chromosomes and cell division -- DNA technology and applications -- Mapping and identifying genes for monogenic disorders -- Developmental genetics -- Patterns of inheritance -- Mathematical and population genetics -- Polygenic and multifactorial inheritance -- Hemoglobin and the hemoglobinopathies -- Biochemical genetics -- Pharmacogenetics -- Immunogentics -- Cancer genetics -- Genetic factors in common diseases -- Congenital abnormalities and dysmorphic syndromes -- Genetic counseling -- Chromosome disorders -- Single-gene disorders -- Screening for genetic disease -- Prenatal testing and reproductive genetics -- Risk calculation -- Treatment of genetic disease -- Ethical and legal issues in medical genetics.
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  • Introduction: Emotions, emotion regulation, and health / Johan Denollet, Ivan Nyklíček, Ad J.J.M. Vingerhoets -- Coping styles and aggression : a biobehavioral approach / Jaap M. Koolhaas, Sietse F. de Boer -- New avenues in alexithymia research : the creation of alexithymia types / Peter Paul Moormann ... [et al.] -- Current issues in repressive coping and health / Lynn B. Myers ... [et al.] -- Why crying improves our well-being : an attachment-theory perspective on the functions of adult crying / Michelle C.P. Hendriks .. [et al.] -- Emotional intelligence : relationships to stress, health, and well-being / Guus L. van Heck, Brenda L. den Oudsten -- Emotion expression in depression : emerging evidence for emotion context-insensitivity / Jonathan Rottenberg, Christine Vaughan -- Emotion regulation and the anxiety disorders : adopting a self-regulation perspective / Thomas L. Rodebaugh, Richard G. Heimberg -- The clinical assessment and treatment of trauma-related self and affect dysregulation / Annemiek van Dijke -- Emotional inhibition, health, gender, and eating disorders : the role of (over) sensitivity to others / Marrie H.J. Bekker, Sonja T.P. Spoor -- Emotional competence and health in children / Carolien Rieffe, Mark Meerum Terwogt, Francine C. Jellesma -- Crying in psychotherapy : its meaning, assessment, and management based on attachment theory / Judith K. Nelson -- Expressive writing in the clinical context / Joshua M. Smyth, Deborah Nazarian, Danielle Arigo -- Writing for all, for some, or for no one? Some thoughts on the applications and evaluations of the writing technique / Luigi Solano, Maria Bonadies, Michela Di Trani.
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    "Marion Allsopp maps the emergence of a powerful psycho-social idea out of its historical and social circumstances, as the concept of injury or trauma has moved, over the twentieth century, from the description of a physical, visible lesion to a more abstract, psychic harm -- often thought of as an 'invisible wound'. She looks at examples of this 'inward turn' in different academic, professional and administrative contexts in the Anglophone world: US psychiatry; UK tort law; Child Protection and the psychological/psychotherapeutic world of attachment theory, both of which span the Atlantic. How have 'psy' academics and professionals, with all their varied theories and techniques of intervention, contributed to the making of new ideas about an injured inner space? How have they explored the psychic interior; what are the emerging fields of knowledge and political conditions which facilitated the growth of this problem category of psychic harm, creating new claims to injury and new forms of state and non-state power? This mapping is not a description of a march towards some inexorable truth. On the contrary, by showing the ideas ' historical or contingent nature, it questions the inevitability of our 21st century present, in which the concept of psychological harm is so pervasive and taken for granted." -- [Publisher-supplied data]
  • This book describes different kinds of psychological, physical and sexual maltreatment and explains their possible consequences, especially as regards quality of life, psychopathology and sexual life. The focus is specifically on the victims of abuse, who are among the more frail and vulnerable members ofsociety. The book examines the impacts of maltreatment of both children and social minorities, such as homosexuals and gender dysphoric individuals or those affected by disabilities and describes skills that are of value in supporting victims of maltreatment and preventing discrimination. The work will be useful to sexual medicine specialists, medical doctors, psychologists and psychiatrists, as well as graduate students in these disciplines. By fostering a better understanding of discrimination triggers and effects, it will help clinicians to provide improved support through the tailoring of therapies to the needs of maltreated individuals.
  • Moral heuristics and risk / Cass R. Sunstein -- Here's how I feel : don't trust your feelings! / Ronald de Sousa -- If I look at the mass I will never act : psychic numbing and genocide / Paul Slovic -- Marketing risk : emotional appeals can promote the mindless acceptance of risk / Ross Buck and Whitney A. Davis -- Emotions as aids and obstacles in thinking about risky technologies / Dylan Evans -- Risk assessment as virtue / Sabine Döring and Fritz Feger -- Emotions and judgments about risk / Robert C. Roberts -- The moral risks of risky technologies / Peter Goldie -- Ethical imagination : broadening laboratory deliberations / Simone van der Burg -- Emotion in risk regulation : competing theories / Dan M. Kahan -- Emotions within the bounds of pure reason : emotionality and rationality in the acceptance of technological risks / Dieter Birnbacher -- Emotions involved in risk perception : from sociological and psychogical risk studies towards a neosentimentalist meta-ethics / Felicitas Kraemer -- Risk emotions and risk judgments : passive bodily experience and active moral reasoning in judgmental constellations / Mark Coecklebergh -- Emotional reflection about risks / Sabine Roeser.
  • Prologue -- Concepts and approaches -- Empirical studies: Shame and pride : prototypical emotions between biology and culture.
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    "Of blacke cholor, without boyling" -- An impatient war -- "Will you turn me out if I can't get better?" -- Prevention is the cure -- "A distorted version of our normal selves" -- The fruits of long endeavors -- Atossa's war.
  • Empirical likelihood 2001
  • Also available: Print – 2010
    "This annual survey of employers provides a detailed look at trends in employer-sponsored health coverage, including premiums, employee contributions, cost-sharing provisions, and other relevant information. The survey continued to document the prevalence of high-deductible health plans associated with a savings option and included questions on wellness benefits and health risk assessments. The 2010 survey included 3,143 randomly selected public and private firms with three or more employees (2,046 of which responded to the full survey and 1,097 of which responded to an additional question about offering coverage). Researchers at the Kaiser Family Foundation, the National Opinion Research Center at the University of Chicago, and Health Research & Educational Trust designed and analyzed the survey"--Website.
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  • Emulsion-based vaccine adjuvants / Christopher Fox, Darrick Carter & Steven G. Reed -- MF59® : an oil-in-water adjuvant / Jennifer Whitaker, Nadine Rouphael & Mark J. Mulligan -- AS03 adjuvant / Woolf T. Walker & Saul N. Faust -- Innovations in emulsion technology / Christopher B. Fox, Darrick Carter, Susan L. Baldwin, & Steven G. Reed -- Index.
  • The role of atomistic modeling of molecules and organic compounds in biology and pharmaceutical research is constantly increasing, providing insights on chemical and biological phenomena at the highest resolution. To achieve relevant results, however, computational biology has to deal with systems containing at least 1000 atoms. Such big molecules cause large computational demands and impose limitations on the level of theory used to describe molecular interactions. Classical molecular mechanics based on various empirical relationships has become a workhorse of computational biology, as a practical compromise between accuracy and computational cost. Several decades of classical force field development have seen many successes. Nevertheless, more accurate treatment of bio-molecules from first principles is highly desirable. Hartree-Fock (HF) and density functional theory (DFT) are two low-level ab initio methods that provide sufficient accuracy to interpret experimental data. They are therefore the methods of choice to study large biological systems. Recently DFT has been applied to calculate single point energy of a solvated Rubredoxin protein. The system contained 2825 atoms and required more than two hours on a supercomputer with 8196 parallel cores. This study clearly demonstrates the scale of problems one has to tackle in first principles calculations of biologically relevant systems. Dynamical simulations requiring thousands of single point energy and force evaluations therefore appear to be completely out of reach. This fact has essentially prohibited the use of first principles methods for many important biological systems. Fortunately, the computer industry is evolving quickly and novel computing architectures such as graphical processing units (GPUs) are emerging. The GPU is an indispensable part any modern desktop computer. It is special purpose hardware responsible for graphics processing. Most problems in computer graphics are embarrassingly parallel, meaning they can be split into a large number of smaller subproblems that can be solved in parallel. This fact has guided GPU development for more than a decade; and modern GPUs evolved into a massively parallel computing v architecture containing hundreds of basic computational units, which all together can perform trillions of arithmetic operations per second. The large computational performance and low price of consumer graphics cards makes it tempting to consider using them for computationally intensive general purpose computing. This fact was recognized long ago and several groups of enthusiasts attempted to use GPUs for non-graphics computing in the early 2000's. One of the few successes from these attempts is now known as Folding@Home. These early attempts were primarily stymied by three major problems: lack of adequate development frameworks, limited precision available on GPUs, and the difficulty of mapping existing algorithms onto the new architecture. The two former impediments have been recently alleviated by the introduction of efficient GPU programming toolkits such as CUDA and the latest generation of graphics cards supporting full double precision arithmetic operations in hardware. These advances led to an explosion of interest in general purpose GPU computing and led to the development of many GPU-based high performance applications in various fields such as classical molecular dynamics, magnetic resonance imaging, and computational fluid dynamics. Most of the projects, however, lie far outside of quantum chemistry which is likely caused by the complexity of quantum chemistry algorithms and the associated difficulty of mapping them onto the GPU architecture. Various specific features of the hardware require complete redesign of conventional HF and DFT algorithms in order to fully benefit from the large computational performance of GPUs. We have successfully solved this problem and implemented the new algorithms in TeraChem, a high performance general purpose quantum chemistry package designed for graphical processing units from the ground up. Using TeraChem, we performed the first ab initio molecular dynamics simulation of an entire Bovine pancreatic trypsin inhibitor (BPTI) protein for tens of picoseconds on a desktop workstation with eight GPUs operating in parallel. Coincidently, this was also the first protein ever simulated on a computer using the classical molecular mechanics approach. BPTI binds to trypsin with a binding free energy of approximately 20 kcal/mol, making BPTI one of the strongest non-covalent binders. It vi is even more remarkable that a single BPTI amino acid LYS15 contributes half of the binding free energy by forming a salt bridge with one of the trypsin's negatively charged residues inside the binding pocket. In fact, the LYS15's contribution to the overall binding energy is approximately twice as large as what would be expected based on experimental measurements of salt bridge interactions in other proteins. Our simulation of BPTI demonstrated that substantial charge transfer occurs at the proteinwater interface, where between 2.0 and 3.5 electrons are transferred from the interfacial water to the protein. This effect decreases the net protein charge from +6e as observed in gas-phase experiments to +4e or less. We demonstrate how this effect may explain the unusual binding affinity of the LYS15 amino acid.
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    v. 1. A-K -- v. 2. L-Z.
  • v. 1. A-K -- v. 2. L-Z.
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    v. 1. A-K -- v. 2. L-Z.
  • Foundation topics. Biology of aging / Teresa Dolinar. The history and demography of aging in the United States / Gail E. Souare, Linda S. Lloyd. Cultural diversity among elders in the US : meeting the challenge of the ethnogeriatric imperative / Gwen Yeo. Legal aspects of aging / Janet L. Lowder ... [et al.] The participation of cognitivelly impaired elderly in research / Sana Loue -- Topics in aging and public health.
  • "This encyclopedia advances the understanding of behavioral medicine principles and clinical applications among researchers and practitioners in medicine, psychology, public health, epidemiology, nursing, and social work. In addition, the encyclopedia provides useful synergies for sociologists, anthropologists, and undergraduates with some interest in the interface of human health and behavior. Areas covered include quality of life and lifespan issues; population, health policy, and advocacy issues; health promotion and disease prevention; behavioral care in all types of settings; biological, psychological, and person factors in health behavior change; professional development and practice-related issues; and much more. This encyclopedia is the first resource to which readers turn for factual, relevant, and comprehensive information to aid in delivering the highest quality services."--Publisher's website.
  • Subject Classification: -- Addiction -- Animal Models of Behavior -- Behavioral Genetics -- Brain Aging -- Brain Structure and Function -- Cognitive Neuroscience -- Disease and Dysfunction -- Developmental Biology -- Emotion and Emotional Behavior -- Ethology and Neuroethology -- Evolution and Comparative Biology -- History -- Language and Communication -- Learning and Memory -- Molecular Neurobiology -- Motivation and Reward -- Motor Systems and Motor Control -- Neuroplasticity -- Psychoneuroendocrinology -- Reproductive , Parental and Sexual behavior -- Sensation and Perception -- Sleeping, Waking and Arousal -- Social Behavior/Cognition -- Stress.
  • The Encyclopedia of Biostatistics, 2nd Edition offers a reference to support the development and use of statistical methods for addressing the problems and critical issues that confront scientists, practitioners and policy makers engaged in the life and medical sciences.
  • V. 1. A-B -- v. 2. C -- v. 3. D-G -- v. 4. H-L -- v. 5. M-O -- v. 6. P-R -- v. 7. S-Z.
  • This major reference work will break new ground as an electronic resource for students, educators, researchers and professionals. Encyclopedic in breath Child Behavior and Development will serve as a reference repository of knowledge in the field as well as a frequently updated conduit of new knowledge long before such information trickles down from research to standard textbooks. Child Behavior and Development will consist of three volumes divided by the major conceptual areas of child development: Learning, Behavior, and Emotions. Taking advantage of the techniques offered by the electronic medium, Child Behavior and Development will offer an extensive cross referencing system facilitating search and retrieval of information.
  • v. 1. A-C -- v. 2. D-K -- v. 3. L-P -- v. 4. Q-Z.
  • Encyclopedia of data warehousing and mining 2006
    books24x7, SUNet ID login required.
    v. 2 books24x7
    "The Encyclopedia of Data Warehousing and Mining provides a comprehensive, critical and descriptive examination of concepts, issues, trends, and challenges in this rapidly expanding field of data warehousing and mining (DWM). This encyclopedia consists of more than 350 contributors from 32 countries"--Provided by the publisher.
  • Encyclopedia of database technologies and applications 2006
    books24x7, SUNet ID login required.
  • v. 1. A-K -- v. 2. L-Z.
  • The Encyclopedia of Exercise Medicine is intelligently structured, easy accessible and user-friendly: A-Z format, clear, concise language and uniform essay structure as well as extensive cross references between keywords and related articles enables efficient searches in a user-friendly manner both for experts and newcomers. It is intended to be a comprehensive up-to-date data base on the adaptation of the human body to exercise and on the therapeutic use of exercise with up to 2,000 keywords. It covers all aspects within the full range of modern exercise medicine of each particular scientific discipline (cancer, parasitology, aging, etc.). This includes information on methodological approaches to measuring the principle components of motor fitness, and practical aspects of their enhancement by trainings regimes as well as by nutrition and the application of drugs. Such a wide range of entries, all written by leading experts in their respective fields, will therefore address both the basic/clinical scientist as well as the practitioner. Moreover, the Encyclopedia of Exercise Medicine is aimed at people in related fields, health care professionals, physiotherapists, trainers, students, informed athletes and interested laypersons. It is available both in print and as a fully searchable and hyperlinked electronic online edition.
  • The definitive resource for what to eat for maximum health, as detailed by medical and nutritional experts, "Encyclopedia of Foods" makes the connection between health, disease, and the food people eat.
  • SU Catalog (SearchWorks) Click LINK above for Print location/circulation status.
    v. 1. Genetics -- v. 2. Genetics -- v. 3. Genomics -- v. 4. Genomics -- v. 5. Proteomics -- v. 6. Proteomics -- v. 7. Bioinformatics -- v. 8. Bioinformatics.
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  • Aging and the heart -- Alcohol and the heart -- Altitude and pulmonary edema -- Anatomy of the heart and circulation -- Anderson-Fabry disease -- Anemia and the heart -- Aneurysm -- Angina -- Angioplasty/coronary balloon -- Angiotensin-converting enzyme inhibitors/angiotensin receptor blockers -- Antihistamines -- Antioxidants -- Antiphospholipid antibody syndrome -- Antiplatelet agents -- Arginine and the heart -- Arrhythmias/palpitations -- Arteriosclerosis -- Artificial heart -- Aspirin for heart disease -- Atherosclerosis/atheroma -- Athletes and sudden cardiac death -- Atrial fibrillation -- Atrial septal defect -- B-type natriuretic peptide -- Beriberi heart disease -- Beta-blockers -- Blood clots -- Blood pressure -- Brugada syndrome -- Bundle branch block -- Caffeine and the heart -- Calcium antagonists -- Carcinoid heart disease -- Cardiogenic shock -- Cardiomyopathy -- Cardiopulmonary resuscitation (CPR) -- Chagas disease -- Chelation and heart disease -- Chemotherapy-induced heart disease -- Cholesterol -- Coenzyme Q10 -- Congenital heart disease -- Contraception and cardiovascular disease -- Coronary artery bypass surgery -- C-reactive protein and the heart -- Cytochrome P-450 -- Deep vein thrombosis -- Depression and the heart -- Diabetes and cardiovascular disease -- Diets and heart disease -- Diuretics -- Down syndrome -- Dyslipidemia -- Echocardiography -- Effects of smoking and heart disease -- Electrocardiography -- Embryology -- Endocarditis -- Endocrine disorders and the heart -- Erectile dysfunction and the heart -- Exercise and the heart -- Gene therapy -- Heart attacks -- Heart failure -- Hemochromatosis -- Herbal, dietary supplements, and cardiovascular disease -- HIV and the heart -- Homocysteine and cardiovascular disease -- Hypertension -- Hypertrophy of the heart -- Kawasaki heart disease -- Miscellaneous disorders -- Murmurs and heart disease -- Nonsteroidal anti-inflammatory drugs -- Obesity and heart disease -- Pacemakers -- Patent foramen ovale -- Pericarditis and myocarditis -- Pulmonary arterial hypertension -- Pulmonary embolism -- Race and cardiovascular disease -- Sleep and the heart -- Stents -- Stress and heart disease -- Stroke/cerebrovascular accident -- Syncope -- Tests for heart diseases -- Thyroid heart disease -- Valve diseases -- Ventricular fibrillation -- Women and heart disease.
  • Part 1. Immigrant Health Overview Chapters -- Immigration in the Global Context / Bettina Rausa, Linda S. Lloyd -- Immigration Processes and Health in the U.S.: A Brief History / Sana Loue -- Alternative and Complementary Medicine / Brenda L. Lovell, Jamileh Daneshnia, Christopher J. Fries -- Culture-Specific Diagnoses / Delaney Smith, Tara Mayes, Riley Smith -- Health Determinants / M. David Low, Barbara J. Low -- Occupational and Environmental Health / Doug Brugge, C. Eduardo Siqueira -- Methodological Issues in Immigrant Health Research / Patrick J. M. Murphy, Irin Rachel Allen , Mo-Kyung Sin -- Ethical Issues in Research with Immigrants and Refugees / Sana Loue -- Ethical Issues in the Clinical Context / Beatrice Gabriela Ioan -- Part 2. Immigrant Health Topics A-Z.
  • "The aim of this comprehensive encyclopedia is to provide detailed information on intensive care medicine contributing to the broad field of emergency medicine. Entries A - Z covering the following disciplines: neurologic problems, respiratory disorders, cardiovascular disorders, gastrointestinal disorders, nutrition therapy, metabolic disorders, renal disorders, infectious diseases, hematologic disorders, special populations, emergency medicine, trauma, ICU procedures, special issues."--Publisher.
  • A fully searchable, working editorial site of articles by scientists and scientific historians in the fields of biochemistry and physiology, cell biology, developmental biology, ecology, evolution, genetics, immunology, molecular biology, neuroscience, microbiology and virology, plant science, structural biology, and science and society.
  • In biochemistry, a metalloprotein is a generic term for a protein that contains a metal cofactor. The metal may be an isolated ion or may be coordinated with a nonprotein organic compound, such as the porphyrin found in hemoproteins. In some cases, the metal is co-coordinated with a side chain of the protein and an inorganic nonmetallic ion. This kind of protein-metal-nonmetal structure is seen in iron-sulfur clusters Metalloproteins deals with all aspects related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The biological roles of metal cations and metal-binding proteins are endless. They are involved in all crucial cellular activities. Many pathological conditions are related to the problematic metal metabolism. Research in metalloprotein-related topics is therefore rapidly growing, and different aspects of metal-binding proteins progressively enter curricula at Universities and even at the High School level on occasion. However, no key resource providing basic, but comprehensible knowledge on this rapidly expanding field exists. The Encyclopedia of Metalloproteins aims to bridge this gap, and will attempt to cover various aspects of metalloprotein/metalloproteomics and will deal with the different issues related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The goal is to cover exhaustively all catalytically and biologically crucial metal ions and to find at least one interacting protein for other metal ions. The Encyclopedia of Metalloproteins will provide a key resource for advanced undergraduate and graduate students, researchers, instructors, and professors interested in protein science, biochemistry, cell biology, and genetics.
  • Subject Classification: -- Applied Microbiology: Agro/Food -- Applied Microbiology: Industrial -- Archaea -- Bacteria -- Cell Structure Chemical Composition -- Environmental Microbiology and Ecology -- Evolution and Systematics -- Fungi -- Genetics, Genomics -- History and Culture, (and Biographies) -- Mutualism and Commensalism -- Pathogenesis -- Physiology -- Protists -- Public Issues -- Techniques -- Viruses.
  • "Explores all areas of the discipline in its focused entries on a wide variety of topics in neurology, psychiatry and other related areas of neuroscience"--About page.
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  • General Otolaryngology -- Pediatric Otolaryngology -- Head and Neck Surgery -- Otology-Neurotology -- Plastic and Reconstructive Surgery.
  • This is the most comprehensive overview available anywhere on the broad, multi-faceted and complex topic of pain and the rapidly evolving scientific and medical disciplines that seek to understand, assess and treat pain. The second edition of theEncyclopedia of Pain is fully updated andhas been expanded by over 100 new essays. It includes more than 3,000 entries and provides clear, detailed and up-to-date coverage of the current state of research, and treatment of pain. In addition, detailed essays provide in-depth information on all aspects of nociception and pain, including substrates, causes, pathophysiology, symptoms and signs, diagnoses and treatment. More than 600 color figures enhance understanding of this too-little-understood topic. Solidly structured and inclusive, this reference is an invaluable tool for clinical scientists and practitioners in academia, health care and industry, as well as students, teachers and interested laypersons.
  • v. 1. A-G -- v. 2. H-O -- v. 3. P-Z.
  • v. 1. A-M -- v. 2. N-Z.
  • Public Health is one of the fastest growing university programs in the United States today. At the same time, the challenges that face the practitioner continue to grow and become more complex. This Encyclopedia of Primary Prevention and Health Promotion, 2nd ed covers more than 250 topics, taking a lifespan approach to the fields of public health and prevention. The encyclopedia is divided into four volumes: 1. Foundational Topics 2. Early Childhood and Childhood 3. Adolescence 4. Adulthood and Older Adulthood Within each volume, issues of illness prevention and health promotion (sometimes referred to as "positive psychology") are addressed in chapter-length entries arranged alphabetically. An international group of contributors synthesizes research focusing on improving the physical and mental health of the community as a whole. Each entry will have a structured format: Introduction, Definition of Terms, Prevalence, Theories, Empirical Studies, and Strategies (What Works, What Is Promising, What Doesn't Work). Each entry concludes with a look ahead to the coming decades of Public Health - what are the next steps to primary prevention and health promotion - and a "See Also" box recommending books, films, or articles by the editors for further reading. The encyclopedia is designed for practitioners, students, and researchers working in prevention, public health, and psychology. It will also serve as reference for practitioners in sociology, social work, nursing and medicine. The second edition more than doubles the number of entries in the first edition by adding entries focusing on gender, African American and Latino issues, social support, social and emotional learning, and physical health and disease. All entries from the first edition will be rewritten and expanded, reflecting the most up to date thinking in the field.
  • Offers a definitive and intellectually rigorous collection of psychological interpretations of the stories, rituals, motifs, symbols, doctrines, dogmas, and experiences of the world's religious and mythological traditions.
  • SECTION I: SCIENTIFIC FOUNDATIONS OF RADIATION ONCOLOGY -- Part A: Radiobiology -- Part B: Physics -- SECTION II: Techniques and Modalities -- SECTION III: DISEASE SITES -- Part A: Central Nervous System Tumors Overview -- Part B: Head and Neck Tumors Overview -- Part C: Thoracic Neoplams Overview -- Part D: Gastrointestinal Tumors Overview -- Part E: Genitourinary Tumors Overview -- Part F: Gynecologic Tumors Overview -- Part G: Breast Cancer Overview -- Part H: Sarcoma and Benign Disease -- Part I: Childhood Cancers Overview -- Part J: Lymphoma & Hematologic Malignancies Overview.
  • Key Essays: Active Avoidance / Marie-Louise G. Wadenberg -- Aggressive Behavior: Clinical Aspects / Emil F. Coccaro, -- Aminergic Hypothesis for Schizophrenia / Hiroyuki Uchida and Shitij Kapur -- Animal Models for Psychiatric States / Paul Willner -- Antipsychotic Drugs / W. Wolfgang Fleischhacker -- Anti-Parkinson Drugs / Joseph H. Friedman -- Antipsychotic Medication: Future Prospects / Seiya Miyamoto -- Cognitive Behavioral Therapy for People with Schizophrenia / Gillian Haddock -- Cognitive Remediation in Schizophrenia Patients / Alice Medalia and Alice Saperstein -- Delayed Onset of Drug Effects / Stefan Leucht -- Delusional Disorder / Istvan Bitter -- Dissociative Anesthetics / Anthony Absalom and David Menon -- Family Based Approaches for Schizophrenia Patients / Andrea Fiorillo and Silvana Galderisi -- First-Generation Antipsychotics / Cyril Höschl -- Hallucinations / Eileen M. Joyce -- Hallucinogen / Abuse and Dependence / John H. Halpern, Pedro E. Huertas, Joji Suzuki, and Torsten Passie -- Neurotoxicity and Schizophrenia / Heleen B. M. Boos, H. D. Postma, and Wiepke Cahn -- Pediatric Schizophrenia / Christoph U. Correl -- Pharmacogenetics of Antipsychotic Drug Response in Schizophrenia / Eva J. Brandl and Daniel J. Müller -- Pharmacogenetics of Drug Side Effects and Safety / Anil K. Malhotra and Todd Lencz -- Postpsychotic Depressive Disorder of Schizophrenia / Samuel G. Siris -- Pre-psychotic States and Prodromal Symptoms / Patrick D. Mcgorry, Alison R. Yung -- Psychoeducation in the Management of Schizophrenia / Werner Kissing and Gabriele Pitschel-Walz -- Rating Scales and Diagnostic Schemata / David V. Sheehan and Kathy H. Sheehan -- Rehabilitation in Schizophrenia / Wulf Rössler and Andreas Marneros -- Schizophrenia / Alex Hofer -- Second and Third Generation Antipsychotics / Gary Remington.
  • Includes biomedical and health applications, biomedical sensing, cure and health monitoring, drug deliversy systems, health monitoring using wave dynamics, polymers, biotechnology and medical applications.
  • Reference tool covering statistics, probability theory, biostatistics, quality control, and economics with emphasis in applications of statistical methods in sociology, engineering, computer science, biomedicine, psychology, survey methodology, and other client disciplines.
  • v. 2, 2011 Springer
    v. 3, 2011 Springer
    v. 4, 2011 Springer
    v. 5, 2011 Springer
    v. 6, 2011 Springer
    v. 1. Isolated compounds A-C -- v. 2. Isolated compunds D-G -- v. 3. Isolated compunds H-M -- v. 4. Isolated compunds N-S -- v. 4. Isolated compunds N-S -- v. 5. Isolated compunds T-Z, references, TCM plants and congeners -- v. 6. Indexes.
  • From the contents: Overview of general trauma care. Injury epidemiology and control. Trauma system development and design. Injury scoring. Trauma outcome measures. Prehospital care of the trauma patient -- Early evaluation and management of the trauma patient. Initial assessment of the injured patient. Airway management in the trauma patient. Blood product utilization and resuscitation strategies following injury. Medications vital to trauma resuscitation. Role of ED thoracotomy -- Organ systems approach: Head. Neck. Chest. Abdomen. Urological. Vascular. Musculoskeletal. Specific considerations in trauma care: Pediatric trauma. Trauma in the elderly. Trauma in pregnancy. Combat casualty care. Burn injury -- Imaging in the trauma patient. Anesthesia management in trauma. Ethical issues in trauma care. Disaster and mass-casualty care. Blast injury. Rehabilitation: Brain injury rehabilitation. Rehabilitation following traumatic injury -- Complications in trauma care -- Critical care for the trauma patient.
  • v. 1. A-L -- v. 2. M-Z.
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    "From one of the world's foremost physicians and researchers, a monumental work that radically redefines our conventional conceptions of health and illness to offer new methods for living a long, healthy life. After considering the discoveries that have led to progress in treating some diseases, Dr. David B. Agus asked an essential question: Why aren't we better at curing illnesses like cancer? Based on his groundbreaking research and the clinical trials he has conducted at the nation's leading medical centers, he came to the realization that we've been approaching medicine from a faulty perspective, and the best way to prevent and combat maladies like cancer, heart disease, autoimmune disorders, and neurodegeneration is to first embrace a totally new view of the human body. What Is Health? asks readers to reconsider everything they think they know about health--and give up believing many myths that may actually be causing them harm and decreasing longevity. These myths revolve around a spectrum of misconceptions, from the benefits of vitamins and supplements to the role of DNA in one's fate. In attempting to reduce our understanding of ailments to a mutation, germ, or deficiency, Dr. Agus proves we have forgotten that the body is a complex system. He presents a systemic picture of the body's vast mechanisms that drive it either toward or away from sickness, empowering readers to take charge of their individual health in very personal, customized ways they've never imagined before. Along the way, Dr. Agus offers insights and access to breathtaking and powerful new technologies that promise to transform medicine in our generation. He also shows that there is no "right" answer in health decisions. This is a radically different approach that will not only change how we care for ourselves, but also how we develop the next generation of treatments and cures. What Is Health? represents a dramatic departure from orthodox thinking that promises to revolutionize our quest for long, healthy lives"-- Provided by publisher.
  • People with advancing neurological disease face increasing physical symptoms, along with psychosocial and spiritual issues affecting both themselves and their families and carers. There is increasing awareness that the end of life in neurological disease can be anticipated and recognised, taking into account certain key features of disease progression, and the associated issues can be addressed. The individual can prepare for future changes in their health, and be in a stronger position to influence or direct the care they receive. End of Life Care in Neurological Disease encourages health and social care professionals to become closely involved in the care of these people and their families, to maintain and maximise quality of life and plan ahead. This book addresses the principles and practice of end of life care for neurological disease, is written with a clinical, multidisciplinary focus, and is enriched with detailed case studies. This book is an accessible text for the multidisciplinary team in specialist palliative care, and will also be of interest to healthcare professionals in neurological services, including neurologists and neurology specialist nurses, rehabilitation services, general practitioners and community nurses. As care professionals, we are in a powerful position to help those who are living with advanced neurological disease and improve their quality of life and death.
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    Chapter 13. Meeting Gary Glazer.
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    "At the turn of the twentieth century, smallpox claimed the lives of two million people per year. By 1979, the disease had been eradicated and victory was declared across the globe. Yet the story of smallpox remains the exception, as today a host of deadly contagions, from polio to AIDS, continue to threaten human health around the world. Spanning three centuries, The End of Plagues weaves together the discovery of vaccination, the birth and growth of immunology, and the fight to eradicate the world's most feared diseases. From Edward Jenner's discovery of vaccination in 1796, to the early nineteenth-century foundling voyages in which chains of orphans, vaccinated one by one, were sent to colonies around the globe, to the development of polio vaccines and the stockpiling of smallpox as a biological weapon in the Cold War, world-renown immunologist John Rhodes charts our fight against these plagues, and shows how vaccinations gave humanity the upper hand. Today, aid groups including the Bill and Melinda Gates Foundation and the World Health Organization have made the eradication of polio a priority, and Rhodes takes us behind the scenes to witness the hard-fought battles of scientist, philanthropists, volunteers, and more, and how soon we may be celebrating the eradication of a second infectious disease, polio"--Provided by publisher.
  • Endemic cretinism 2011
  • Endocannabinoids and monoamines: modulating the modulators -- Endocannabinoid-mediated synaptic plasticity -- Current cannabinoid receptor nomenclature and pharmacological principles -- Cue-elicited craving for cannabis activates the reward neurocircuitry associated with the neuropathology of addiction -- Cannabinoid modulation of dopaminergic circuits in neurodegenerative and neuropsychiatric disorders -- Pathophysiology of mood disorders and mechanisms of action of antidepressants and mood stabilizers -- Anatomical, biochemical and behavioral evidence for cannabinoid modulation of noradrenergic circuits: role of norepinephrine in cannabinoid-induced aversion -- Gender Disparity of Depression: The Role of Endocannabinoids and Noradrenergic Function -- Endocannabinoids, Monoamines and Stress -- Chronic effects of cannabinoid drugs on monoaminergic systems and the role of endocannabinoids and cannabinoid receptors in human brain disorders -- Endocannabinoid Signaling and the Regulation of the Serotonin System -- Modulation of serotonin firing activity through CB1 agonists and FAAH inhibitors -- Involvement of serotonergic system in cannabinoid analgesia -- Cannabinoids, monoamines, COMT and schizophrenia: pathobiological mechanisms in psychosis.
  • Part 1. Overview of Non-Cannabinoid Receptors -- Overview of Nonclassical Cannabinoid Receptors / Grzegorz Godlewski and George Kunos -- Overview of Non-CB1/CB2 Cannabinoid Receptors: Chemistry and Modeling / Evangelia Kotsikorou and Patricia Reggio -- Part 2. G-Protein Coupled Receptors -- GPR55 in the CNS / Hui-Chen Lu, Jane E. Lauckner, John W. Huffman and Ken Mackie -- The Role of GPR55 in Bone Biology / Lauren S. Whyte and Ruth A. Ross -- The Role of GPR55 in Cancer / Clara Andradas, María M. Caffarel, Eduardo Pérez-Gómez, Manuel Guzmán and Cristina Sánchez -- GPR18 and NAGly Signaling: New Members of the Endocannabinoid Family or Distant Cousins? / Douglas McHugh and Heather B. Bradshaw -- Cannabinoid Signaling Through Non-CB1R/Non-CB2R Targets in Microglia / Neta Rimmerman, Ewa Kozela, Rivka Levy, Zvi Vogel and Ana Juknat -- Part 3. Ion Channels -- Temperature-Sensitive Transient Receptor Potential Channels as Ionotropic Cannabinoid Receptors / Vincenzo Di Marzo and Luciano De Petrocellis -- Nonpsychoactive Cannabinoid Action on 5-HT3 and Glycine Receptors / Li Zhang and Wei Xiong -- Part 4. Transcription Factors -- Peroxisome Proliferator-Activated Receptors and Inflammation / James Burston and David Kendall -- Peroxisome Proliferator-Activated Nuclear Receptors and Drug Addiction / Paola Mascia, Gianluigi Tanda, Sevil Yasar, Stephen J. Heishman and Steven R. Goldberg -- Part 5. Conclusions/Therapeutic Potential -- Conclusions: Therapeutic Potential of Novel Cannabinoid Receptors / Mary E. Abood, Roger G. Sorensen and Nephi Stella.
  • This volume updates its classic predecessor in both content and format. Written by two of the respected authorities in diagnostic endocrinology, it includes detailed information on how to perform and interpret those laboratory test procedures used to confirm the clinical diagnosis of the majority of known endocrine disorders. Newly designed, it provides a standardized format that makes it easier to access complete information about the diagnosis, screening, and management of traditional and newly perceived endocrine disorders. It provides sample calculations to assist with complex formulas as well as ICD-9 codes for all procedures.
  • Introduction to the endocrine system -- Endocrine function of the gastrointestinal tract -- Energy metabolism -- Calcium and phosphate homeostasis -- Hypothalamus-pituitary complex -- The thyroid gland -- The adrenal gland -- Life cycle of the male and female reproductive system -- The male reproductive system -- The female reproductive system -- Fertilization, pregnancy, and lactation.
  • In silico methods for modeling endocrine disruption / James Devillers -- Mechanisms of endocrine disruptions : a tentative overview / Jean-Marc Porcher, James Devillers, and Nathalie Marchand-Geneste -- Population dynamics modeling : a tool for environmental risk assessment of endocrine disrupting chemicals / Andrew R. Brown ... [et al.] -- Application of pharmacokinetic modeling to understand the mechanism of action of endocrine disrupting chemicals / James Devillers -- Comparative modeling review of nuclear hormone receptor superfamily / Nathalie Marchand-Geneste and James Devillers -- The U.S. Food and Drug Administration's (FDA) Endocrine Disruptor Knowledge Base (EDKB) : lessons learned in QSAR modeling and applications / Hong Fang ... [et al.] -- A structure-activity relationship (SAR) analysis for the identification of environmental estrogens : the categorical-SAR (cat-SAR) approach / Albert R. Cunningham ... [et al.] -- Kohonen and counterpropagation neural networks employed for modeling endocrine disruptors / Marjana Novič and Marjan Vračko -- Quantitative spectrometric data-activity relationships (QSDAR) models of endocrine disruptor binding activities / Richard D. Beger, Dan A. Buzatu, and Jon G. Wilkes -- Mechanism-based modeling of estrogen receptor binding affinity : a Common Reactivity Pattern (COREPA) implementation / Ovanes Mekenyan and Rossitsa Serafimova -- Molecular field analysis methods for modeling endocrine disruptors / Jean-Pierre Doucet and Annick Panaye -- Structure-activity modeling of a diverse set of androgen receptor ligands / James Devillers ... [et al.] -- SAR and QSAR analyses of substituted dibenzoylhydrazines for their mode of action as ecdysone agonists / Toshio Fujita and Yoshiaki Nakagawa -- e-Endocrine disrupting chemical databases for deriving SAR and QSAR models / Nathalie Marchand-Geneste ... [et al.].
  • 1. Introduction to Endocrine Disruptors and Puberty / Evanthia Diamanti-Kandarakis and Andrea C. Gore -- pt. I. EDCs, Endocrine Systems, and Puberty -- 2. In Utero Exposure to Environmental Chemicals: Lessons from Maternal Cigarette Smoking and Its Effects on Gonad Development and Puberty / Rebecca McKinlay, Peter O'Shaughnessey, Richard M. Sharpe, and Paul A. Fowler -- 3. Reproductive Neuroendocrine Targets of Developmental Exposure to Endocrine Disruptors / Sarah M. Dickerson, Stephanie L. Cunningham, and Andrea C. Gore -- 4. Endocrine Disruptors and Puberty Disorders from Mice to Men (and Women) / Alberto Mantovani -- 5. Thyroid Hormone Regulation of Mammalian Reproductive Development and the Potential Impact of Endocrine-Disrupting Chemicals / Kara Renee Thoemke, Thomas William Bastian, and Grant Wesley Anderson -- pt. II. Developmental Exposure to Endocrine Disruptors and adverse reproductive outcomes -- 6. Developmental Exposure to Endocrine Disruptors and Ovarian Function / Evanthia Diamanti-Kandarakis, Eleni Palioura, Eleni A. Kandaraki -- 7. Developmental Exposure to Environmental Endocrine Disruptors and Adverse Effects on Mammary Gland Development / Suzanne E. Fenton, Lydia M. Beck, Aditi R. Borde, and Jennifer L. Rayner -- 8. Developmental Exposure to Endocrine Disruptors and Male Urogenital Tract Malformations / Mariana F. Fernandez and Nicolas Olea -- 9. EDC Exposures and the Development of Reproductive and Nonreproductive Behaviors / Craige C. Wrenn, Ashwini Mallappa, and Amy B. Wisniewski -- pt. III. Developmental Exposure to Endocrine Disruptors and Metabolic Disorders -- 10. Adipocytes as Target Cells for Endocrine Disruption / Amanda Janesick and Bruce Blumberg -- 11. Altered Glucose Homeostasis Resulting from Developmental Exposures to Endocrine Disruptors / Alan Schneyer and Melissa Brown -- 12. Developmental Exposure to Endocrine Disrupting Chemicals: Is There a Connection with Birth and Childhood Weights? / Elizabeth E. Hatch, Jessica W. Nelson, Rebecca Troisi, and Linda Titus -- pt. IV. EDCs and Human Health -- 13. The Impact of Endocrine Disruptors on Female Pubertal Timing / Jean-Pierre Bourguignon and Anne-Simone Parent -- 14. The Influence of Endocrine Disruptors on Male Pubertal Timing / Xiufeng Wu, Ningning Zhang, and Mary M. Lee -- 15. Secular Trends in Pubertal Timing: A Role for Environmental Chemical Exposure? / Vincent F. Garry and Peter Truran.
  • Endocrine Emergencies: Recognition and Treatment offers a state-of-the-art update on the management of endocrine, diabetic, and metabolic emergencies. Developed by renowned experts, this comprehensive and easy to read title brings the field fully up to date, setting a high standard for diagnosis and treatment in each category. All chapters begin with a summary that presents, in concentrated form, what the physician needs to know to begin the evaluation and emergency treatment of the known endocrine emergencies. This is followed by an extended discussion of the pathophysiology that can be read after initial treatment has begun. Covering such areas as hypoglycemia, acute adrenal insufficiency, ovarian hyperstimulation syndrome, thyroid storm, and pituitary apoplexy, just to name several, Endocrine Emergencies: Recognition and Treatment is an invaluable, practical resource that will be of great interest to endocrinologists, internal medicine and emergency room physicians, fellows and residents.
  • Also available: Print – 2012
    The Structural Biology of the FGF19 Subfamily / Andrew Beenken and Moosa Mohammadi -- Klotho and βKlotho / Makoto Kuro-o -- FGF23 and Syndromes of Abnormal Renal Phosphate Handling / Clemens Bergwitz and Harald Jüppner -- Evidence for FGF23 Involvement in a Bone-Kidney Axis Regulating Bone Mineralization and Systemic Phosphate and Vitamin D Homeostasis / Aline Martin and L. Darryl Quarles -- FGF23, Klotho and Vitamin D Interactions: What Have We Learned from In Vivo Mouse Genetics Studies? / M. Shawkat Razzaque -- FGF23 and the Parathyroid / Justin Silver and Tally Naveh-Many -- Regulation of Ion Channels by Secreted Klotho / Chou-Long Huang -- FGF23 in Chronic Kidney Disease / Patricia Wahl and Myles Wolf -- Secreted Klotho and Chronic Kidney Disease / Ming Chang Hu, Makoto Kuro-o and Orson W. Moe -- FGF23 as a Novel Therapeutic Target / Takashi Shimada and Seiji Fukumoto -- Physiology of FGF15/19 / Stacey A. Jones -- FGF19 and Cancer / Benjamin C. Lin and Luc R. Desnoyers -- Understanding the Structure-Function Relationship between FGF19 and Its Mitogenic and Metabolic Activities / Xinle Wu and Yang Li -- FGF21 as a Therapeutic Reagent / Yang Zhao, James D. Dunbar and Alexei Kharitonenkov.
  • Machine generated contents note: pt. I Adrenal Hypertension -- 1. Primary Aldosteronism: Progress in Diagnosis, Therapy, and Genetics / Franco Veglio -- 2. Syndromes of Mineralocorticoid Excess / Christian A. Koch -- 3. Hypertension in Patients with Cushing's Syndrome / George P. Chrousos -- 4. Primary Generalized Familial and Sporadic Glucocorticoid Resistance (Chrousos Syndrome) and Hypersensitivity / George P. Chrousos -- 5. Congenital Adrenal Hyperplasia / Deborah P. Merke -- 6. Adrenal Incidentalomas and Arterial Hypertension / George P. Chrousos -- 7. Pheochromocytoma: Unmasking the Chameleon / Karel Pacak -- pt. II Other Potential Causes of Endocrine Hypertension -- 8. Hypertension in Growth Hormone Excess and Deficiency / George R. Merriam -- 9. Primary Hyperparathyroidism and Hypertension / Shonni J. Silverberg -- 10. Hypertension, Vitamin D Deficiency, and Calcium Metabolism / Vin Tangpricha -- 11. Testosterone Deficiency or Male Hypogonadism / Michael Zitzmann -- 12. Insulin Resistance and Hypertension / Helmut O. Steinberg -- 13. Obesity-Associated Hypertension / Gabriel I. Uwaifo -- 14. Central Mineralocorticoid Receptors and Cardiovascular Disease / Elise P. Gomez-Sanchez.
  • Inherited and sporadic epimutations at the IGF2-H19 locus in Beckwith-Wiedemann syndrome and Wilms' tumor / Riccio, A. ... [et al.] -- Epigenetic regulation of growth : lessons from Silver-Russell syndrome / Eggermann, T. -- Genetic imprinting : the paradigm of Prader-Willi and Angelman syndromes / Gurrieri, F., Accadia, M. -- Muscle involvement and IGF-1 signaling in genetic disorders : new therapeutic approaches / Barberi, L. ... [et al.] -- Mitochondrial encephalomyopathies and related syndromes : brief review / Bertini, E., D'Amico A. -- Overgrowth syndromes : a classification / Neri, G., Moscarda, M. -- C-type natriuretic peptide and overgrowth / Bocciardi, R., Ravazzolo, R. -- Role of transcription factors in midline central nervous system and pituitary defects / Kelberman, D., Dattani, M.T. -- Developmental abnormalities of the posterior pituitary gland / Di Iorgi, N. ... [et al.] -- Hyperinsulinism in developmental syndromes / Kapoor, R.R., James, C., Hussain, K. -- Developmental syndromes : growth hormone deficiency and treatment / Mazzanti, L. ... [et al.] -- Growth hormone-resistant syndromes : long-term follow-up / Chernausek, S.D. -- Phenotypic aspects of growth hormone- and IGF-I-resistant syndromes / Savage, M.O. ... [et al.] -- Double diabetes : a mixture of type 1 and type 2 diabetes in youth / Pozzilli, P., Guglielmi, C. -- Cryptorchidism as part of the testicular dysgenesis syndrome : the environmental connection / Main, K.M., Skakkebaek, N.E., Toppari, J. -- Disorders of sex development in developmental syndromes / Hiort, O., Gillessen-Kaesbach, G.
  • This book is one of the first to evaluate the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements and focuses on the importance of steroidal hormones in the pathogenesis and therapeutical management of the autoimmune rheumatic diseases. In particular, the chapters analyze the mechanisms of action and the involvement of adrenal steroids (glucocorticoids) in the neuroendocrine immune system, including the effects on elderly. The perturbations of the HPA axis as source of altered steroidal sythesis will be discussed and related to some interesting pathological conditions often complicating the autoimmune rheumatic diseases susch as psychosis or fibromyalgia. Concerning the role of gonadal steroids (sex hormones), several chapters will discuss clinical and epidemiological evidences of their role, as well as their effects as risk factors in autoimmune rheumatic diseases, including a section in Pediatrics. *The premier issue evaluating the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements *Documents the latest research and indicate recent and coming new therapeutical-biological approaches to the therapy *The book will present therapeutical perspectives concerning the new glucocorticoids, and the effects of biological drugs on their synthesis.
  • Endocrine neoplasia 2010
    Also available: Print – 2010
    Part. I Thyroid.-- Biology of thyroid oncogenesis / Insoo Suh, Electron Kebebew.-- Evaliation of the thyroid nodule / Dina M. Elaraj.-- Differentiated thyroid cancers of follicular cell origin / Linwah Yip, Sally E. Carty.-- Sporadic medullary thyroid cancer / Adrian Harvey, Janice L. Pasieka.-- Anaplastic thyroid cancer / Alan P.B. Dackiw.-- Part II. Parathyroid.-- Primary hyperparathyroidism / Kaitlyn J. Kelly, Herbert Chen, Rebecca S. Sippel.-- Parathyromatosis and parathyroid cancer / Wen T. Shen.-- Part III. Incidentaloma / Jacob Malem, Insoo Suh, Quan-Yang Duh.-- Pheochromocytoma and paraganglioma / Goswin Y. Meyer-Rochow, Stan B. Sidhu.-- Functional cortical neoplasms / Ali Zarrinpar, Michael W. Yeh.-- Adrenocortical carcinoma / Patsy S.H. Soon, Stan B. Sidhu.-- Part IV. Pnacreatic neuroendocrine tumors.-- Gastrinoma / Anthony J. Chambers, Janice L. Pasieka.-- Insulinoma / Kimberly Vanderveen, Clive Grant.-- Rare neuroendocrine tumors of the pancreas / Shih-Ping Cheng, Gerard M. Doherty.-- Part V. Multiple endocrine neoplasia.-- Menin gene / Hsin-Chieh Jennifer Shen, Steven K. Libutti.-- Multiple endocrine neoplasia type I: clinical manifestations and management / Anathea C. Powell, Steven K. Libutti.-- RET protooncogene / Amber L. Traugott, Jeffrey F. Moley.-- Multiple endocrine neoplasia type 2: clinical manifestations and management / Amber L. Traugott, Jeffrey F. Moely.
  • Methods in cellular and molecular pathology / Paul Komminoth ... [et al.] -- Hypothalamus and neurohypophysis / Kazuhiro Takahashi, Osamu Murakami, and Toraichi Mouri -- Tumors in the adenohypophysis / Fateme Salehi ... [et al.] -- Recent developments in molecular embryogenesis and molecular biology of the pituitary / Robert Y. Osamura and Noboru Egashira -- Recent developments in the molecular biology of pituitary tumors / Ricardo V. Lloyd -- The pineal gland / Katherine M. Lindstrom and M. Beatriz S. Lopes -- The parathyroid / H. Rubén Harach -- Recent developments in the molecular biology of the parathyroid / Vânia Nosé and Ashraf Khan -- Pathology of thyroid gland / Ashraf Khan and Vânia Nosé -- Recent developments in the molecular biology of the thyroid / Yuri E. Nikiforov -- Adrenal cortex / Hironobu Sasano ... [et al.] -- Adrenal medulla and paraganglia / Anne Marie McNicol -- Molecular biology of pheochromocytomas and paragangliomas / Elizabeth E. King and Patricia L.M. Dahia -- Endocrine ovaries / Xavier Matias Guiu -- Endocrine testis / Robert E. Emerson, Liang Cheng, and Thomas M. Ulbright -- Endocrine tumors of the gastrointestinal system / Guido Rindi ... [et al.] -- The endocrine pancreas / Stefano La Rosa ... [et al.] -- Neuroendocrine differentiation patterns in various organs (including lung, breast, skin, and urogenital tract) / Marco Volante ... [et al.] -- Endocrine lung / William D. Travis -- Cutaneous neuroendocrine tumors / Lori A. Erickson -- Neuroendocrine carcinomas of the thymus / Cesar A. Moran and Saul Suster -- Endocrine placenta / Raymond W. Redline -- Fine needle aspiration cytology of endocrine glands / Ema A. Dragoescu and Celeste N. Powers -- Multiple endocrine neoplasia syndrome / Kennichi Kakudo, Yasuhiro Ito, and Masahide Takahashi -- Polyglandular autoimmune diseases / Ricardo V. Lloyd -- Biochemical testing for neuroendocrine tumors / Aaron I. Vinik and Maria P. Silva -- Surgical management of endocrine disorders / Joseph B. Lillegard, Travis J. McKenzie, and Geoffrey B. Thompson -- Medical treatment of neuroendocrine tumors / Timothy J. Hobday -- Radiation treatment of endocrine tumors / Sunil Krishnan, Deepa Suresh, and Robert L. Foote -- Future directions in endocrine pathology / Ricardo V. Lloyd.
  • This book provides comprehensive coverage of the fundamental concepts of hormone biological action. These concepts provide a solid foundation for understanding the physiologic mechanisms involved in neuroendocrine regulation of organ function. -- Publisher description
  • 2013 ClinicalKey
    Continues the tradition of the Secrets Series®, offering fast answers to the most essential clinical endocrinology questions. The Q&A format includes pearls, tips, and memory aids to help you to learn and study efficiently. Provides a concise board review or handy clinical endocrinology resource.
  • Parathyroid disease / William B. Inabnet III, James A. Lee, and Barnard J.A. Palmer -- The thyroid gland / James C. Lee, Justin S. Gundara, and Stanley B. Sidhu -- The adrenal glands / Sebastian Aspinall -- Familial endocrine disease : genetics, clinical presentation, and management / Paul Brennan, Stephen G. Ball, and T.W.J. Lennard -- Endocrine tumours of the pancreas / Robin M. Cisco and Jeffrey A. Norton -- Gastrointestinal neuroendocrine tumours / Goran Akerstrom, Per Hellman, and Ola Hessman -- Clinical governance, ethics, and medico-legal aspects of endocrine surgery / Peter Angelos and Barnard J. Harrison -- The salivary glands / Paula Bradley, James O'Hara, and Janet Wilson.
  • Print Material
  • Print Material
    Receptors and hormone action -- The hypothalamus and pituitary part I : the hypothalamus and posterior pituitary -- The hypothalamus and pituitary part II : the anterior pituitary -- The adrenal glands part I : the adrenal medulla -- The adrenal glands part II : the adrenal cortex -- The thyroid gland -- Hormonal control of reproduction part I : male reproductive system -- Hormonal control of reproduction part II : female reproductive system -- Hormonal control of reproduction part III : development and fertility -- Insulin and the regulation of plasma glucose -- Hormonal regulation of plasma calcium and calcium metabolism -- Miscellaneous hormones.
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    Chemical transmission -- Mechanisms of hormone action 1. Membrane receptors -- Mechanisms of hormone action 2. Intracellular receptors -- Hypothalamus and pituitary gland -- Gonadotrophin releasing hormone : a peptide hormone -- Principles of feedback control -- Growth 1. Cellular growth factors -- Growth 2. Normal growth -- Growth 3. Growth hormone -- Growth 4. Pathophysiology -- Thyroid 1. Thyroid gland and thyroid hormones -- Thyroid 2. Thyroid hormone secretion and action -- Thyroid 3. Thyroid pathophysiology -- Adrenal gland 1. Adrenal medulla -- Adrenal gland 2. Adrenocortical hormones -- Adrenal gland 3. Adrenocorticotrophic hormone (ACTH) -- Adrenal gland 4. Cortisol and androgens -- Adrenal gland 5. Aldosterone -- Adrenal gland 6. Adrenocortical pathophysiology -- Endocrine autoimmunity -- Sexual differentiation and development 1 -- Sexual differentiation and development 2. Puberty -- Female reproduction 1. Menstrual cycle -- Female reproduction 2. Ovarian steroids -- Female reproduction 3. Pregnancy -- Female reproduction 4. Parturition and lactation -- Female reproduction 5. Pathophysiology -- Female reproduction 6. Contraception -- Male reproduction 1. The testis -- Male reproduction 2. Actions of androgens -- Male reproduction 3. Pathophysiology -- Oxytocin -- Vasopressin -- Renin-angiotensin-aldosterone system -- Endocrine hypertension -- Insulin 1. The pancreas and insulin secretion -- Insulin 2. Insulin action -- Insulin 3. Type I Diabetes mellitus -- Insulin 4. Type 2 Diabetes mellitus -- Glucagon -- Gastrointestinal hormones -- Energy homoeostasis 1. Summary -- Energy homoeostasis 2. Central control -- Obesity 1. Causes of obesity -- Obesity 2. Cardiovascular and respiratory complications -- Obesity 3. Insulin resistance and endocrine complications -- Calcium 1. Parathyroid hormone (PTH) -- Calcium 2. Calcitonin -- Calcium 3. Vitamin D -- Bone remodelling -- Metabolic bone disease 1. Paget's disease -- Metabolic bone disease 2. Primary osteoporosis -- Metabolic bone disease 3. Secondary osteoporosis -- Index.
  • Multiple endocrine neoplasia type 1 / Agarwal, S.K. -- Multiple endocrine neoplasia type 2 / Lodish, M. -- Von Hippel-Lindau syndrome / Chou, A. ... [et al.] -- Carney complex -- Espiard, S., Bertherat, J. -- Multiple endocrine neoplasia type 4 / Lee, M., Pellegata, N.S. -- Novel hereditary forms of pheochromocytomas and paragangliomas / Dahia, P.L.M. -- Carney triad / Carney, J.A. -- Genetics of pituitary adenomas / Gadelha, M.R. ... [et al.] -- Clinical behavior and genetics of nonsyndromic, familial nonmedullary thyroid cancer / Bauer, A.J. -- Genetic defects associated with familial and sporadic hyperparathyroidism / Hendy, G.N., Cole, D.E.C. -- Endocrine tumors associated with neurofibromatosis type 1, Peutz-Jeghers syndrome, and other familial neoplasia syndromes / Kalkan, E., Waguespack, S.G.
  • Endocrine updates v. 25-, 2007-
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    V. 1 -- Endocrinology: impact on science and medicine -- Control of hormone gene expression -- Control of hormone secretion -- Insulin and growth factor signaling pathways -- Hormone signaling via G protein-coupled receptors -- Nuclear receptors: structure, function, and coregulators -- Applications of genetics in endocrinology -- Development of the pituitary -- Prolactin -- Adrenocorticotropic hormone -- Endocrine rhythms, the sleep-wake cycle, and biological clocks -- Hypothalamic syndromes -- Hypopituitarism and growth hormone deficiency -- Acromegaly -- Cushing's syndrome -- Clinically nonfunctioning sellar masses -- TSH-producing adenomas -- Disorders of prolactin secretion and prolactinomas -- Pituitary surgery -- Evaluation and management of childhood hypothalamic and pituitary tumors -- Vasopressin, diabetes insipidus, and the syndrome of inappropriate antidiuretic hormone secretion -- The pineal gland and melatonin -- Regulation of growth hormone and action (secretagogues) -- Insulin-like growth factor-1 and its binding proteins -- Somatic growth and maturation -- Growth hormone deficiency in children -- Appetite regulation and thermogenesis -- Obesity: the problem and its management -- Genetic syndromes associated with obesity -- Anorexia nervosa, bulimia nervosa, and other eating disorders -- Development of the endocrine pancreas -- Biosynthesis, processing, and secretion of the islet hormones: insulin, islet amyloid polypeptide (amylin), glucagon, somatostatin, and pancreatic polypeptide -- Insulin secretion -- The mechanisms of insulin action -- Glucagon and the glucagon-like peptides -- Regulation of intermediatory metabolism during fasting and feeding -- Role of the adipocyte in metabolism and endocrine function -- Lipodystrophy syndromes -- Classification and diagnosis of diabetes mellitus -- Type 1 (insulin-dependent) diabetes mellitus: etiology, pathogenesis, prediction, and prevention -- Type 2 diabetes mellitus: etiology, pathogenesis, and natural history -- Lipoprotein metabolism and the treatment of lipid disorders -- Hyperglycemia secondary to nondiabetic conditions and therapies -- The metabolic syndrome -- Treatment of type 1 diabetes mellitus in adults -- Ketoacidosis and hyperosmolar coma -- Hypoglycemia and hypoglycemic syndromes -- Management of type 2 diabetes mellitus -- Management of diabetes mellitus in children -- Pancreatic and islet transplantation -- Diabetes control, long-term complications, and large vessel disease -- Diabetic eye disease -- Diabetes mellitus: neuropathy -- Diabetic nephropathy -- Diabetic foot and vascular complications -- Parathyroid hormone and parathyroid hormone-related peptide in the regulation of calcium homeostasis and bone development -- Calcitonin -- Vitamin D: from photosynthesis, metabolism, and action to clinical applications -- Bone development and remodeling -- Calcium regulation, calcium homeostasis, and genetic disorders of calcium metabolism -- Genetic disorders of phosphate homeostasis -- Primary hyperparathyroidism -- Malignancy-associated hypercalcemia and medical management -- Surgical management of hyperparathyroidism -- Pseudohypoparpathyroidism, Albright's hereditary osteodystrophy, and progressive osseous heteroplasia: disorders caused by inactivating GNAS mutations -- Genetic defects in vitamin D metabolism and action -- Hereditary disorders of the skeleton -- Bone density and imaging of osteoporosis -- Chronic kidney disease mineral and bone disorder -- Disorders of calcification: osteomalacia and rickets -- Paget's disease of bone -- V. 2 -- Anatomy and development of the thyroid -- Thyroid-stimulating hormone: physiology and secretion -- Thyroid regulatory factors -- Thyroid hormone metabolism -- Mechanisms of thyroid hormone action -- Thyroid function testing -- Thyroid imaging -- Autoimmune thyroid disease -- Graves' disease -- Graves' ophthalmopathy -- Autonomously functioning thyroid nodules and other causes of thyrotoxicosis -- Chronic (Hashimoto's) thyroiditis -- Subacute and Riedel's thyroiditis -- Hypothyroidism and myxedema coma -- Nonthyroidal illness syndrome: a form of hypothyroidism -- Multinodular goiter -- Iodine deficiency disorders -- Thyroid neoplasia -- Medullary thyroid carcinoma and multiple endocrine neoplasia type 2 -- Thyroid-stimulating hormone receptor mutations -- Genetic defects in thyroid hormone synthesis and action -- Thyroid hormone binding and variants of transport proteins -- Resistance to thyroid hormone -- Surgery of the thyroid -- The principles, enzymes, and pathways of human steroidogenesis -- Glucocorticoid action: physiology -- Glucocorticoid receptors: their mechanisms of action and glucocorticoid resistance -- Aldosterone: secretion and action -- Glucocorticoid therapy -- Adrenal insufficiency -- Adrenal causes of hypercortisolism -- Defects of adrenal steroidogenesis -- Adrenarche and adrenopause -- Adrenal gland imaging -- Adrenocortical carcinoma -- Primary mineralocorticoid excess syndromes and hypertension -- Mineralocorticoid deficiency -- Pheochromocytoma -- Adrenal surgery -- Hormones of the cardiovascular system -- Hyponatremia and hypernatremia -- Orthostatic hypotension and orthostatic intolerance -- Endocrine aspects of critical care medicine -- Gonadotropin-releasing hormones -- Gonadal peptides: inhibins, activins, follistatin, Müllerian-inhibiting substance (antimüllerian hormone) -- Gonadotropins-regulation of synthesis and secretion -- Genetic basis of gonadal and genital development -- Diagnosis and treatment of disorders of sexual development -- Endocrinology of sexual maturation and puberty -- Precocious puberty -- Delayed puberty -- Hormonal control of breast development -- The endocrinology of sexual behavior and gender identity -- Folliculogenesis, ovulation, and luteogenesis -- Ovarian hormone synthesis -- Estrogen and progesterone action -- Hormonal regulation of the menstrual cycle, mechanisms of ovulation, premenstrual syndromes -- Amenorrhea, anovulation, and dysfunctional uterine bleeding -- Endometriosis -- Female subfertility: evaluation and management -- Hyperandrogenism, hirsutism, and the polycystic ovary syndrome -- Ovulation induction and assisted reproduction -- Contraception -- Menopause -- Functional morphology of the testis -- Androgen physiology, pharmacology, and abuse -- Testicular dysgenesis syndrome, cryptorchidism, hypospadias, and testicular tumors -- Androgen deficiency disorders -- Gynecomastia -- Clinical management of male infertility -- Male contraception -- Endocrinology of the prostate -- The endocrinology of human pregnancy and parturition -- Fetal and neonatal endocrinology -- Diabetes mellitus and pregnancy -- Diagnosis and treatment of thyroid disease during pregnancy -- Hormonal changes and endocrine testing in pregnancy -- Autoimmune polyglandular syndromes -- Multiple endocrine neoplasia type 1 -- Multiple endocrine neoplasia type 2 -- Gastrointestinal hormones and tumor syndromes -- Carcinoid syndrome -- Ectopic hormone syndromes -- Endocrine testing.
  • Endocrinology, and diabetes care in particular, is a dynamic field where clinicians must translate new evidence into clinical practice at a rapid pace. Designed in an engaging, case-based format, Endocrinology and Diabetes: A Problem Oriented Approach offers a wide range of thought-provoking case studies that reflect contemporary, challenging, hands-on clinical care. Further, by providing a list of specific clinical problems, this format offers the reader a more convenient and pointed way to solve precise clinical problems in a timely manner. Developed by a renowned, international group of experts, this comprehensive title covers the most common clinical problems in endocrinology and diabetes and should be of great interest to endocrinologists, diabetologists, internal medicine physicians, family physicians, fellows, and residents.
  • Case 1. Difficult-to-treat hyperthyroidism -- Case 2. Hypothyroidism complicated by hypothyroid coma -- Case 3. Hyperthyroidism in pregnancy -- Case 4. Graves' disease associated with a thyroid nodule -- Case 5. A complicated case of thyroid eye disease -- Case 6. Cushing's Syndrome -- Case 7. Prolactinoma presenting with galactorrhoea and secondary amenorrhoea: diagnosis and management -- Case 8. A 25-year-old woman with headache and joint pain -- Case 9. Recent-onset visual field loss and raised prolactin level (non-functioning pituitary tumour ) -- Case 10. Polyuria and polydipsia -- Case 11. Hypertension in the young adult -- Case 12. Weight loss and dizziness: adrenal failure -- Case 13. Diagnosis and management of polycystic ovary syndrome (PCOS) -- Case 14. Salt-wasting crisis in a newborn -- Case 15. Female infertility: diagnosis and management -- Case 16. Diagnosis and management of hypocalcaemia in adults -- Case 17. Hypoglycaemia case study -- Case 18. Spontaneous hypoglycaemia -- Case 19. Thyroid nodule in a child (MEN 2) -- Case 20. What kind of diabetes? -- Case 21. Managing diabetes in pregnancy -- Case 22. Inability to lose weight -- Case 23. Medical problems in obesity -- Case 24. A case of severe hyponatraemia -- Case 25. Medical problems post bariatric surgery -- Index.
  • Understanding the influence and interaction between physical activity and the endocrine system are of paramount importance in dealing with a multitude of health problems. In Endocrinology of Physical Activity and Sport, renowned physicians and researchers provide a comprehensive and expanded update on the scientific, clinical and practical components of endocrinology as related to sport and exercise. The authors thoroughly review what is known about how such activity affects the endocrine system and how in turn these hormonal responses affect many other organs and systems of the body. In addition, aspects of endocrinology in non-glandular tissue which have endocrine actions are addressed; for example, adipocytes and the release of leptin and related adipocytokines. Further, a wide range of clinically related topics such as athletic amenorrhea, osteopenia, sarcopenia, and hypogonadism are included. This new edition critically integrates what is known about the complex interaction of the endocrine system in the sports context and will again prove immensely valuable to all physicians and clinical investigators treating those active in sports today.
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  • Hypopituitarism following radiotherapy revisited / Darzy, K.H., Shalet, S.M. -- Alterations in pubertal timing following therapy for childhood malignancies / Armstrong, G.T., Chow, E.J., Sklar, C.A. -- Obesity during and after treatment for childhood cancer / Reilly, J.J. -- Metabolic disorders / Gregory, J.W. -- Bone and bone turnover / Crofton, P.M. -- Male fertility and strategies for fertility preservation following childhood cancer treatment / Mitchell, R.T. ... [et al.] -- Fertility in female childhood cancer survivors / De Bruin, M.L. ... [et al.] -- Long-term follow-up of survivors of childhood cancer / Edgar, A.B. ... [et al.].
  • This book reviews the available information on bacterial disinfection in endodontics, with emphasis on the chemical treatment of root canals based on current understanding of the process of irrigation. It describes recent advances in knowledge of the chemistry associated with irrigants and delivery systems, which is of vital importance given that chemical intervention is now considered one of the most important measures in eliminating planktonic microbes and biofilms from the infected tooth. Recommendations are made regarding concentrations, exposure times, and optimal sequences. Possible complications related to the use of the different solutions are highlighted, with guidance on response. In addition, clinical protocols are suggested on the basis of both clinical experience and the results of past and ongoing research. Throughout, a practical, clinically oriented approach is adopted that will assist the practitioner in ensuring successful endodontic treatment.
  • Endodontic pain is a complex symptom that often drives a patient to a dentist in search of relief. In these circumstances, the patient is likely to pose a range of questions: Can you relieve my pain? Will the treatment be painful? How will I feel later? The answers to such questions often form the basis of the patient's assessment of the dentist. The combination of pain and a negative dental experience has physical and psychological sequelae for the patient that may last long after treatment. This book is a concise, well-structured guide to the assessment and treatment of patients who present with endodontic pain, in which step-by-step descriptions are complemented by informative images and flow charts. The advantages, disadvantages, and significance of specific diagnostic and treatment procedures are clearly described, as is a pharmacotherapeutic approach to the prevention and treatment of pain. In addition, the causes and biological basis of endodontic pain are explained and guidance is provided on further strategies for pain prevention. The crisp narrative, efficient design, and visual detail are notable features of this book that will make it an ideal chairside resource for the clinician and a dependable reference for the student.
  • Tooth development, morphology and physiology / Kishor Gulabivala, Yuan-Ling Ng -- Biological and clinical rationale for vital pulp therapy / Kishor Gulabivala, Yuan-Ling Ng -- Biological and clinical rationale for root canal treatment / Kishor Gulabivala, Yuan-Ling Ng -- Diagnosis of endodontic problems / Kishor Gulabivala, Yuan-Ling Ng -- Treatment planning / Kishor Gulabivala, Yuan-Ling Ng -- Pre-endodontic management / Kishor Gulabivala, Yuan-Ling Ng -- Delivery of endodontic treatment -- Vital pulp therapy / Kishor Gulabivala, Yuan-Ling Ng -- Non-surgical root canal treatment / Kishor Gulabivala, Yuan-Ling Ng -- Management of root canal treatment failure / Yuan-Ling Ng, Kishor Gulabivala -- Management of emergencies and traumatic injuries / Kishor Gulabivala, Yuan-Ling Ng -- Management of root resorption / Yuan-Ling Ng, Kishor Gulabivala -- The perio-endo interface / Kishor Gulabivala, Ulpee Darbar, Yuan-Ling Ng -- The ortho-endo interface / Kishor Gulabivala, Farhad Naini -- The restorative-endo interface / Kishor Gulabivala, Yuan-Ling Ng -- The medical-endo interface / Alexander Mustard, Kishor Gulabivala -- The orofacial pain-endo interface / Rachel Leeson, Kishor Gulabivala, Yuan-Ling Ng -- The oral medicine/oral surgery-endo interface / Rachel Leeson, Kishor Gulabivala.
  • Cardiovascular (CV) disease is the leading cause of death worldwide. While death rates from many acute CV illnesses have declined in developing countries, a substantial proportion of individuals with CV disease ultimately die from CV causes. As the population ages, the global burden of CV disease will continue to rise. Until recently, the focus of clinicians has been on saving lives and deferring death. Over the past decade there has been growing recognition of the importance of palliative care and end of life care in CV disease. While palliative and supportive care should be provided throughout the course of serious and life-shortening illnesses, this book focuses on issues that clinicians encounter in end-of-life care. This book provides guidance to clinicians working across the breadth of care settings, in chronic progressive disease as well as sudden arrhythmic death andwith advanced technologies. End-of-Life Care in Cardiovascular Disease is designed to assist clinicians, nurses, and other healthcare providers in addressing end of life care for patients with CV disease in a variety of common clinical scenarios. Each chapter is written by expert clinicians and researchers, and concisely reviews current knowledge and recommendations for providing patient- and family-centered end-of-life care.
  • Introduction -- Chapter 1. Multinational Perspectives on End-of-Life Issues in the Intensive Care Unit -- The United States -- Canada -- New Zealand -- United Kingdom -- Communicating to family: the Israeli perspective -- Maria and the good death: the Latin American view -- The Greek perspective -- The South African perspective -- A perspective from India -- Japan -- Chapter 2. Critical Illness and End-of-Life Issues: A Global View -- An evaluation of international medical ethics at the end of life -- Communication in the Intensive Care Unit -- End-of Life issues in the critically ill: a global perspective -- Chapter 3. Death in a Lonely Place: Pathophysiology of the Dying Patient -- Chapter 4. The History of the Definition(s) of Death: From the 18th Century to the 20th Century -- Chapter 5. What It Feels Like to Live and Die on Prolonged Life Support -- Chapter 6. Who's in Charge in the Intensive Care Unit? -- Chapter 7. Dealing with Difficult Surrogates -- Erring on the side of autonomy -- Erring on the side of reason -- Healthcare providers' contribution to the problem of futility -- Chapter 8. Emotions in the Intensive Care Unit -- Chapter 9. The Role of Ethics Committees in End-of-Life Care -- Chapter 10. Medical Liability Issues in Dealing with Critical Care Patients in the End-of-Life Situation -- Chapter 11. End-of-Life Issues and United States Politics -- Chapter 12. Comments from Ancillary Healthcare Providers -- My experiences with end-of-life as a bedside-nurse -- A Chaplain's perspective -- Pharmacotherapy considerations during end-of-life care of critically ill adults -- Chapter 13. The Intensive Care Unit of the Future -- Afterword.
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  • Part I. Evolution and detection of endogenous ADP-ribosylation. The natural history of ADP-ribosyltransferases and the ADP-ribosylation system / L. Aravind, Dapeng Zhang, Robson F. de Souza, Swadha Anand and Lakshminarayan M. Iyer -- Identification and analysis of ADP-ribosylated proteins / Friedrich Haag and Friedrich Buck -- Part II. ADP-ribosylation by ARTCs (R-S-E ARTs). Photorhabdus luminescens Toxins TccC3 and TccC5: insecticidal ADP-ribosyltransferases that modify threonine and glutamine / Klaus Aktories, Gudula Schmidt and Alexander E. Lang -- Reaction mechanism of mno-ADP-ribosyltransferase based on structures of the complex of enzyme and substrate protein / Hideaki Tsuge and Toshiharu Tsurumura -- Regulation of nitrogenase by reversible mono-ADP-ribosylation / Vivian R. Moure, Flavia F. Costa, Leonardo M. Cruz, Fabio O. Pedrosa, Emanuel M. Souza, Xiao-Dan Li, Fritz Winkler and Luciano F. Huergo -- ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells / Björn Rissiek, Friedrich Haag, Olivier Boyer, Friedrich Koch-Nolte and Sahil Adriouch -- Pierisins and CARP-1: ADP-ribosylation of DNA by ARTCs in butterflies and shellfish / Tsuyoshi Nakano, Azusa Takahashi-Nakaguchi, Masafumi Yamamoto and Masahiko Watanabe -- Part III. ADP-ribosylation by ARTDs (H-Y-E ARTs). Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family / Ana Filipa Pinto and Herwig Schüler -- Function and regulation of the mono-ADP-ribosyltransferase ARTD10 / Max Kaufmann, Karla L.H. Feijs and Bernhard Lüscher -- Regulation of nucleocytoplasmic transport by ADP-tibosylation: the emerging role of Karyopherin-[Beta]1 mono-ADP-ribosylation by ARTD15 / Maria Di Girolamo -- Index.
  • Also available: Print – 2008
    Current status of the prevention and early diagnosis of endometrial adenocarcinoma -- The value of endometrial cytology -- Techniques of endometrial cytology -- Techniques of endometrial histopathology -- New techniques for the diagnosis of endometrial pathology -- Cytology of the normal endometrium - cycling and postmenopausal -- Benign endometrial lesions -- Cytopathology of endometrial hyperplasias -- Cytopathology of endometrial adenocarcinoma -- Cytopathology of the non-epithelial malignant tumors of the uterine corpus.
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  • Endometriosis is one of the most common gynecological diseases, causingpelvic pain, infertility, and cancer. The condition reduces the quality of life for the estimated 10% of menstruating women who are affected by it. This book provides a clear insight intothe pathogenesis and pathophysiology of endometriosis-essentialinformation forcliniciansintending to successfully treat the condition. The first part covers a range of topics including stem cells, NK cells, macrophages, inflammation, cytokines, epigenetics, prostaglandin, sex steroids, aromatase, apoptosis, nerve fibers, and malignant transformation to aid in understanding the pathogenesis and pathophysiology of the disease. The second part provides useful tools for therapy, specifically, notable recent techniques in prevention, imaging, biomarkers, medical treatments, surgical treatments, prevention of recurrence, and infertility treatments. Each chapter was written by an expert in the field, with nearly 40 researchers and clinicians contributing to the work. This book will be highly useful to clinicians as well as to research scientists who are interested in this enigmatic disease.
  • The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as âER stressâ. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome. This book primarily focuses on the pathophysiology of ER stress. It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit. Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases.
  • Survey -- Cavum nasi and fossa pterygopalatina -- Sinus sphenoidalis and fossa pterygopalatina -- Tuba auditiva (eustachii) -- Pyramis (petrous bone, pars petrosa plus pars tympanica) -- Clivus area and pars condylaris -- Special surgical aspects examples.
  • "Increasingly used as an adjunctive tool in the diagnosis and management of ear disease, middle ear endoscopy has the potential to decrease patient morbidity, prevent disease recurrence, and reduce costs. Its capacity to uncover hidden anatomy within the small dimensions of the ear has made it essential for functional surgery, allowing surgeons to preserve key anatomic structures such as the cochlea and facial nerve. Now for the first time, the physicians who pioneered this groundbreaking minimally invasive technique review its indications, advantages, disadvantages, and surgical approaches. Written by the foremost leaders in the field, all members of the International Working Group on Endoscopic Ear Surgery. Features nearly 1,000 intraoperative endoscopic images filmed with high-definition cameras, plus outstanding line drawings that aid in understanding all concepts. Comprehensively covers the field, including chapters on endoscopic and combined endoscopic-microscopic management of cholesteatoma, surgical restoration of middle ear ventilation, myringoplasty, Meniere disease, tympanoplasty and stapes surgery, revision surgery, and much more. Demonstrates state-of-the-art endoscopic procedures in 19 instructive videos. From the unique anatomy and pathophysiology of the middle ear through diagnosis, surgical indications, procedures, and instrumentation, this book is indispensable for all otolaryngologists and neurotologists. It offers a full picture of the field today, as well as exploring the future possibilities of ear endoscopes alone or in combination with operative microscopes for the most effective treatment of middle ear pathologies"--Provided by publisher.
  • Owing to the alterations in visceral anatomy, many endoscopists, and especially trainees, experience difficulties when performing endoscopic surveys or procedures in patients who have previously undergone surgery to the digestive tract. In this richly illustrated book, an expert in the field provides a detailed overview of endoscopic follow-up of gastrointestinal (esophageal, gastric, and colorectal) anastomosis. Both normal appearances and pathological conditions involving complications are fully covered. The methodology, timing, protocols, and role of diagnostic endoscopy are first discussed. Endoscopic treatments for the resolution of different clinical problems related to recurrences, stenoses, dehiscences, and fistulas are then evaluated step by step with the aid of high-quality images. Regardless of level of experience, endoscopists and gastroenterologists will find Endoscopic Follow-up of Digestive Anastomosis to be an invaluable source of information and aid to treatment in this important area, which too often receives insufficiently detailed attention.
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  • Barrett's esophagus : screening, diagnosis, and management / Glenn M. Eisen -- Endoscopic screening for squamous cell carcinoma of the esophagus / Brian C. Jacobson -- Image enhancement endoscopy / Stephan M. Wildi and Michael B. Wallace -- Staging of esophageal cancer / Jason Vollweiler and Gregory Zuccaro, Jr. -- Endoscopic therapy for early esophageal cancer and premalignant lesions in Barrett's esophagus / Granapathy A. Prasad and Kenneth K. Wang -- Endoscopic therapy for advanced esophageal cancer / Sanjay Jagannath and Marcia I. Canto -- Radiological imaging of the upper gastrointestinal tract / Marc S. Levine -- Esophageal cancer therapy : surgery, radiation, and chemotherapy / John M. Holland and Christopher A. Canning -- Premalignant lesions of the stomach / Omid A. Shaye and Andrew Ippoliti -- Gastric polyps / George A. Makar and Gregory G. Ginsberg -- Endoscopic ultrasound for staging gastric cancer / Gregory Olds and Amitabh Chak -- Endoscopic treatment for gastric cancer / Takuji Gotoda and Roy M. Soetikno -- Diagnosis and management of gastrointestinal lymphoma / John G. Kuldau, Peter R. Holman, and Thomas J. Savides -- Gastrointestinal stromal tumors / Raquel E. Davila -- Carcinoid tumors / Wilscott E. Naugler and Gordon C. Hunt -- Medical and surgical therapy for gastric cancer / Diane Hershock -- Colorectal cancer screening / Jason A. Dominitz and William M. Grady -- Polyposis and familial cancer syndromes / Fernando S. Velayos, Madhulika G. Varma, and Jonathan P. Terdiman -- Endoscopic colon surveillance : post-polypectomy, post-colorectal cancer resection, and inflammatory bowel disease / Douglas B. Nelson and Mandeep S. Sawhney -- Endoscopic ultrasound for staging rectal and anal cancer / Deepak V. Gopal -- Endoscopic therapy of colorectal carcinoma / Vaman Jakribettuu and Yang K. Chen -- Radiological imaging of the lower gastrointestinal tract / Steven E. Rubesin -- Current status of colorectal cancer therapy / John Strother ... [et al.] -- Cystic neoplasms of the pancreas / William R. Brugge -- Diagnosis and evaluation of pancreatic ductal adenocarcinoma / Kenneth H. Yu and Nuzhat A. Ahmad -- Adenocarcinoma of the pancreas : endoscopic palliation / Georgios I. Papachristou, Kevin McGrath, and Adam Slivka -- Pancreatic neuroendocrine tumors / Erik-Jan Wamsteker and James M. Scheiman -- Endoscopic diagnosis and management of cholangiocarcinoma / Vanessa M. Shami and Irving Waxman -- Ampullary neoplasia / Ian D. Norton -- Magnetic resonance imaging of neoplasms of the pancreatobiliary system / Evan S. Siegelman and Wendy C. Hsu -- Medical and surgical therapy of pancreatic cancer / Weijing Sun, Jon Morris, and Jeffrey Drebin -- Endoscopic ultrasound for thoracic disease / Timothy Woodward, Massimo Raimondo, and Michael B. Wallace.
  • 1. History of Pituitary Surgery -- 2. Anatomy of the Pituitary Gland and Parasellar Region -- 3. Endoscopic Equipment -- 4. Preoperative Endocrine Evaluation -- 5. Radiographic Evaluation of Pituitary Tumors -- 6. Indications for Surgery on Pituitary Tumors: An Endocrinologist's Perspective -- 7. Indications for Surgery on Pituitary Tumors: A Neurosurgeon's Perspective -- 8. Histology of Pituitary Tumors -- 9. Prolactinomas and Apoplexy -- 10. Acromegaly -- 11. Cushing's Disease -- 12. Thyroid-Stimulating Hormone Tumors -- 13. Clinical Management of Nonfunctioning Pituitary Adenomas -- 14. Neuro-Ophthalmologic Considerations -- 15. Endoscopic Transsphenoidal Approach to the Sella -- 16. Clinical Pearls in Endoscopic Pituitary Surgery: A Neurosurgeon's Perspective -- 17. Clinical Pearls in Endoscopic Pituitary Surgery: An Otolaryngologist's Perspective -- 18. Virtual Endoscopy in Endoscopic Pituitary Surgery -- 19. 3D Stereoendoscopic Pituitary Surgery -- 20. Endoscope-Assisted Transsphenoidal Surgery -- 21. Endoscopic Pituitary Surgery in the Cavernous Sinus -- 22. Microscopic versus Endoscopic Transsphenoidal Pituitary Surgery -- 23. Microscopic and Endoscopic Transsphenoidal Pituitary Surgery: A Reasoned and Balanced Dialectic -- 24. Extended Endonasal, Endoscopic Transsphenoidal Approach versus Craniotomy for Giant Pituitary Macroadenomas -- 25. Stereotactic Radiosurgery and Fractionated Radiation for Pituitary Tumors -- 26. Atypical Adenoma, Pituitary Carcinoma, and the Role of Chemotherapy in the Management of Refractory Pituitary Adenoma -- 27. The Utility of Intraoperative MRI in Pituitary Surgery -- 28. Limited Utility of Intraoperative MRI in Endoscopic Pituitary Surgery -- 29. The Role of Stereotactic Navigation in Endoscopic Pituitary Surgery -- 30. Anesthesia Considerations -- 31. Managing Postoperative Sinusitis -- 32. Managing Carotid Injury During Transsphenoidal Surgery -- 33. Managing Postoperative CSF Leak -- 34. Postoperative and Neurocritical Care Management of Patients after Endonasal Endoscopic Transsphenoidal Pituitary Surgery -- Index.
  • Endoscopic spine procedures 2011
    Thieme eNeurosurgery
    "As the understanding of human physiology has become more complete, the importance of preserving normal tissues has become increasingly clear in the field of surgery. This understanding gave birth to the concept of minimally invasive surgery that has conquered almost all surgical fields, including spine surgery. With recent advances and experience, minimally invasive spinal surgery (MISS) is gradually replacing conventional spine surgical procedures. The primary goal of MISS is to achieve outcomes comparable to those of open surgery while minimizing normal tissue damage and reducing recovery times. Advances in optics, radionavigation, and laser technology made MISS more accessible to surgeons and truly less invasive for the patient. Minimally invasive surgical techniques have touched the entire spinal column, from the cervical to the lumbosacral spine. The MISS spectrum ranges from simple disk surgeries to the most complicated spine surgeries, such as deformity correction. Of all MISS procedures, percutaneous endoscopic disk surgery has attracted the most attention from the global spine surgery community and has enjoyed phenomenal advances in sophistication in the past decade. The remainder of the chapter presents a historical account of percutaneous disk surgeries for the lumbar and cervical spine. "--Provided by publisher.
  • Also available: Print – 2005
  • History of ESD -- Indications of ESD in the Upper Gastrointestinal Tract -- Indication for Colorectal ESD -- Role of EUS on Preoperative Staging of Gastric Cancer for ESD -- Advanced Endoscopic Imaging in the Upper Gastrointestinal Tract -- Advanced Endoscopic Imaging in the Lower Gastrointestinal Tract -- Injection Material for ESD -- Eastern Perspective -- Submucosal Fluid Cushion Injection Fluid -- Western Perspective -- Electrocautery -- Endoscopic Submucosal Dissection for Superficial Esophageal Cancer -- ESD Technique: Stomach -- Endoscopic Submucosal Dissection Technique: Colorectum -- How to Conquer Difficult ESD: Duodenum, Fibrosis, and More -- Prevention of Stricture Formation after Esophageal Endoscopic Submucosal Dissection -- Regenerative Medicine for Stricture Management: What does the Future Hold? -- Prevention, Identification, and Treatment of Hemorrhage -- Management of Gastrointestinal EMR & ESD perforation: From Lab to Practice -- Identification, Treatment, and Prevention of Complications: Perforation in the Upper Gastrointestinal Tract -- Prevention, Identification, and Treatment of Perforation in the Lower Gastrointestinal Tract -- Post-resection surveillance -- POEM -- ESD Expansion: NOTES ? Eastern perspective -- ESD Expansion: NOTES ? The Western Perspective -- ESD Training in the East -- ESD training in Western Countries.
  • Also available: Print – 2005
  • New technologies for imaging of Barrett's esophagus -- Argon plasma coagulation in Barrett's esophagus: the most widely available technique -- Radiofrequency ablation for eradication of Barrett's esophagus: a description of the endoscopic technique, its clinical results, and future prospects -- Decision making in ablation: disease, patients, and institutional factors -- Multipolar electrocoagulation (MPEC): an early, widely available technique -- Endoscopic mucosal resection in Barrett's esophagus: endoscopic surgery -- Combination: multimodal therapy -- Photodynamic therapy (PDT): the best-validated technique -- Cyroablation of Barrett's esophagus -- Cost-effectiveness of endoscopic therapy for Barrett's esophagus.
  • Endosonographic instrumentation -- Probe ultrasonography -- Radial endoscopic ultrasound -- Linear endoscopic ultrasound -- The cytopathology of endoscopic ultrasound-guided fine needle aspiration -- Pitfalls in endoscopic ultrasound -- The role of EUS in esophageal cancer -- Role of EUS in mediastinal nodes, masses, cysts, and lung cancer -- The role of endoscopic ultrasound in gastric cancer -- The role of EUS in subepithelial lesions -- Endoscopic ultrasound of ampullary and duodenal lesions -- The role of EUS in pancreatic cancer -- The role of EUS in cystic lesions of the pancreas -- The role of EUS in the biliary system -- The role of EUS in rectal cancer and fecal incontinence -- Interventional endoscopic ultrasound-guided cholangiopancreatography -- Endoscopic ultrasound-guided drainage of pancreatic fluid collections -- Endoscopic ultrasound-guided celiac plexus block and celiac plexus neurolysis -- Fine needle injection therapy -- Contrast-enhanced endoscopic ultrasound -- Endosurgical applications of EUS -- The future of EUS.
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    Basics of radial endoscopic ultrasound -- Longitudinal EUS anatomy -- EUS meets VOXEL-MAN: a computer-based training system for longitudinal EUS -- Miniprobes -- Intraductal ultrasound -- Radial EUS, linear EUS, or ultrasound miniprobe: which if the most suitable device? -- Ultrasound contrast agents and contrast-enhanced ultrasonography.
  • The Evaluation, Diagnosis, and Treatment of Inflammatory Bowel Diseases over the Past 100 Years: A Brief Review -- Ultrasound -- Fluoroscopic Techniques for the Interrogation of IBD Patients -- CT Enterography in Crohn's Disease -- Magnetic Resonance Enterography (MRE) -- Role of Endoscopy in Diagnosis of Crohn's Disease and Chronic Ulcerative Colitis -- Capsule Endoscopy in the Evaluation of Inflammatory Bowel Disease -- Balloon-assisted Enteroscopy: Techniques, Diagnostic and Therapeutic Yield and Application in Small Bowel Crohn?s Disease -- Spiral Enteroscopy: Technique, Diagnostic and Therapeutic Yield and Application in Small Bowel Crohn?s Disease -- Diseases That Can Mimic IBD -- Histopathologic Diagnosis of Inflammatory Bowel Disease -- Role of Mucosal Healing -- Role of Endoscopy to Define Postoperative Recurrence in IBD -- The Use of Endoscopy to Follow the Clinical Course of Crohn?s Disease -- Endoscopy in Crohn's Disease of the Pouch -- Endoscopic Surveillance for Neoplasia in IBD: Random Biopsy -- The Near Future of Endoscopic Screening in IBD -- Surveillance for Neoplasia in the Patient with an Ileal Pouch -- Pathology DALM -- Endoscopic Approach to Resection of Polypoid and Non-Polypoid Dysplasia in IBD -- Endoscopic Treatment of Complications of Inflammatory Bowel Diseases -- Diagnosis and Treatment: ERCP in PSC -- Future of Endoscopy and IBD.
  • This volume reviews the history of endoscopy to diagnose small bowel disorders, places other diagnostic modalities into perspective, and defines the role of capsule endoscopy and per overtube assisted and retrograde enteroscopy in disorders as disparate as gluten sensitive enteropathy, small bowel neoplasms, and inflammatory bowel disease. The book further details the nonoperative approach to NSAID strictures, foreign body retrieval (to include impacted capsule endoscopes), and the diagnosis and treatment of chronically bleeding angiodysplastic lesions. The text is also richly illustrated with over 150 images and includes online video segments. Written by experts in the field, Endoscopy in Small Bowel Disorders is a valuable resource for medical and surgical residents, gastroenterologists in training and practice, therapeutic endoscopists, and general and colorectal surgeons.
  • The purpose of this book is to improve diagnostic yields of capsule endoscopy and double-balloon endoscopy, because those procedures can depict nonspecific findings that may not lead to a proper diagnosis. Another reason for the publication was recognition of the difficulty in distinguishing enteroscopic findings of ulcerative colitis from those of Crohn's disease. From a practical point of view, it is important to observe endoscopic pictures first, then to compare the images of other modalities, and finally to compare macroscopic pictures of resected specimens. For that reason, a large number of well-depicted examples of small intestinal lesions were assembled to clarify differences among small intestinal lesions that appear to exhibit similar findings and morphologies. Comparisons with radiographic findings comprise another important element in diagnosis. There are limitations in endoscopic observations of gross lesions of the small intestine, with its many convolutions. In Japan, many institutions still practice double-contrast imaging, which provides beautiful results. Because a single disorder may exhibit variations, this volume includes multiple depictions of the same disorders. Also included are lesions in active and inactive phases, as both appearances are highly likely to be encountered simultaneously in clinical practice. The number of illustrated findings therefore has been limited to strictly selected cases.
  • pt. B ScienceDirect
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  • From diagnostic to therapeutic procedures, Endosonography, 3rd Edition is an easy-to-access, highly visual guide covering everything you need to effectively perform EUS, interpret your findings, diagnose accurately, and choose the best treatment course. World-renowned endosonographers help beginners apply endosonography in staging cancers, evaluating chronic pancreatitis, and studying bile duct abnormalities and submucosal lesions. Practicing endosonographers can learn cutting-edge techniques for performing therapeutic interventions such as drainage of pancreatic pseudocysts and EUS-guided anti-tumor therapy. Meticulous updates, electronic access to the fully searchable text, videos detailing various methods and procedures-and more-equip you with a complete overview of all aspects of EUS. Get a clear overview of everything you need to know to establish an endoscopic practice, from what equipment to buy to providing effective cytopathology services.
  • Free-Living Protozoa with Endosymbiotic Methanogens / Tom Fenchel and Bland J. Finlay -- Anaerobic Ciliates and Their Methanogenic Endosymbionts / Johannes H. P. Hackstein -- Symbiotic Methanogens and Rumen Ciliates / Kazunari Ushida -- The Methanogenic and Eubacterial Endosymbionts of Trimyema / Naoya Shinzato and Yoichi Kamagata -- Termite Gut Flagellates and Their Methanogenic and Eubacterial Symbionts / Yuichi Hongoh and Moriya Ohkuma -- Methanogens in the Digestive Tract of Termites / Andreas Brune -- Methanogenic Archaea in Humans and Other Vertebrates / Everly Conway de Macario and Alberto J. L. Macario -- Methanogens in the Gastro-Intestinal Tract of Animals / Johannes H. P. Hackstein and Theo A. van Alen -- Syntrophy in Methanogenic Degradation / Petra Worm, Nicolai Müller, Caroline M. Plugge, Alfons J. M. Stams and Bernhard Schink -- Hydrogenosomes / Johannes H. P. Hackstein and Aloysius G. M. Tielens -- Evolution of Prokaryote-Animal Symbiosis from a Genomics Perspective / Rosario Gil, Amparo Latorre and Andrés Moya.
  • Endotext <2000>
    Endotext ( is an online resource on endocrine disease written by physicians and directed toward physicians around the world caring for patients with these problems. It is organized by Leslie J De Groot, MD, twelve section editors, and nearly 400 authors. It is comprehensive, authoritative, constantly updated, and unbiased. Endotext, covering the broad area of Clinical Endocrinology, emphasizes clinical endocrine practice and includes the most current information on the manifestations of endocrine disease, diagnosis, and treatment.
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  • The endothelial cytoskeleton : multifunctional role of the endothelial actomyosin cytoskeleton / Yuka Shimizu and Joe G.N. Garcia -- Emerging themes on pulmonary microvascular endothelial cell : microtubules and microtubule associated proteins / Cristiaan D. Ochoa, Ron Balczon, and Troy Stevens -- Endothelial actin cytoskeleton and angiogenesis / Sadiqa K. Quadri -- Adherens junctions and endothelial cytoskeleton / Younes Smani and Tarik Smani-Hajami -- Mechanical force transmission via the cytoskeleton in vascular endothelial cells / Bori Mazzag ... [et al.] -- The functional role of the microtubule/microfilament cytoskeleton in the regulation of pulmonary vascular endothelial barrier / Irina B. Alieva and Alexander D. Verin -- Membrane-cytoskeleton interactions and control of vesicle trafficking in endothelial cells / Felicia Antohe -- Cell-matrix adhesion proteins in the regulation of endothelial permeability / Jurjan Aman, Geerten P. van Nieuw Amerongen, and Victor W.M. van Hinsbergh -- Endothelial cells and the regulation of platelet function / P.C. Redondo ... [et al.].
  • Also available: Print – 2010
  • Print Material
  • Endotoxin in the pathogenesis of sepsis / Marshall, J.C. -- Endotoxins and other sepsis triggers / Opal, S.M. -- Rationale of extracorporeal removal of endotoxin in sepsis : theory, timing and technique / Ronco, C., Piccinni, P., Kellum, J. -- Extracorporeal removal of endotoxin : the polymyxin B-immobilized fiber cartridge / Tani, T. ... [et al.] -- Mechanisms of polymyxin B endotoxin removal from extracorporeal blood flow : molecular interactions / Vesentini, S. ... [et al.] -- Mechanisms of polymyxin B endotoxin removal from extracorporeal blood flow : hydrodynamics of sorption / Fiore, G.B. ... [et al.] -- Endotoxin removal by polymyxin B immobilized cartridge inactivates circulating proapoptotic factors / Martin, E.L., Ranieri, V.M. -- Polymyxin-B hemoperfusion and endotoxin removal : lessons from a review of the literature / Cruz, D.N. ... [et al.] -- PMX endotoxin removal in the clinical practice : results from the EUPHAS trial / Antonelli, M. ... [et al.] on behalf of the EUPHAS Study Group -- Early management of endotoxemia using the endotoxin activity assay and polymyxin B-based hemoperfusion / Novelli, G. ... [et al.] -- Endotoxin activity level and septic shock : a possible role for specific anti-endotoxin therapy? / Monti, G. ... [et al.] -- Endotoxin removal : how far from the evidence? : from EUPHAS to EUPHRATES / Rachoin, J.-S. ... [et al.] -- Endotoxin removal : how far from the evidence? : the EUPHAS 2 project / Martin, E.L. ... [et al.].
  • Endotoxins: Lipopolysaccharides of Gram-negative bacteria / X. Wang and P.J. Quinn -- Purification and characterization of lipopolysaccharides / X. Wang ... [et al.] -- Endotoxins: Relationship between structure, function, and activity / K. Brandenburg, A.B. Schromm and T. Gutsmann -- The diversity of the core oligosaccharide in lipopolysaccharides / A. Silipo and A. Molinaro -- Salmonella-regulated lipopolysaccharide modifications / S.M. Richards, K.L. Strandberg and J.S. Gunn -- The variation of O antigens in Gram-negative bacteria / L. Wang, Q. Wang and P.R. Reeves -- Regulators of TLR4 signaling by endotoxins / A.F. McGettrick and L.A.J. O'Neill -- Membrane partitioning: Is location everything when it comes to endotoxin recognition? / M. Triantafilou and K. Triantafilou -- Endotoxin detection - from limulus amebocyte lysate to recombinant Factor C / J.L. Ding and B. Ho -- The role of endotoxin in infection: Helicobacter pylori and Campylobacter jejuni / A.P. Moran -- The role of pseudomonas lipopolysaccharide in cystic fibrosis airway infection / S.M. Moskowitz and R.K. Ernst -- Development of small-molecule endotoxin sequestering agents / S.A. David and D. Sil -- Development of an anti-endotoxin vaccine for sepsis / A.S. Cross -- Synthetic and natural TLR4 agonists as safe and effective vaccine adjuvants / C.B. Fox ... [et al.] -- Targeting endotoxin in the treatment of sepsis / J.-S. Rachoin, C.A. Schorr and R.P. Dellinger -- Lipopolysaccharides in rhizobium-legume symbioses / R.W. Carlson, L.S. Forsberg and E.L. Kannenberg -- Lipopolysaccharides and plant innate immunity / G. Erbs ... [et al.].
  • Merging of endourology and oncology: endourooncology / A. El-Hakim, B.R. Lee, and A.D. Smith -- Surgical robots and three-dimensional displays for computer-aided surgery / T. Dohi -- Robot-assisted (Da Vinci) urologic surgery: an emerging frontier / A.K. Hemal and M. Menon -- Robotic surgery assisted by the ZEUS system / M. Eto and S. Naito -- Telesurgery: remote monitoring and assistance laparoscopy / T. Inagaki, S.B. Bhayani, and L.R. Kavoussi -- Remote percutaneous renal access using a telesurgical robotic system / B. Challacombe, L. Kavoussi, and D. Stoianovici -- Radiofrequency ablation for percutaneous treatment of malignant renal tumors / S. Kanazawa, T. Iguchi, K. Yasui, H. Mimura, T. Tsushima, and H. Kumon -- High-intensity focused ultrasound for noninvasive renal tumor thermoablation / A. Häckr, M.S. Michel, and K.U. Köhrmann -- High-intensity focused ultrasound (HIFU) for the treatment of localized prostate cancer / T. Uchida, H. Ohkusa, H. Yamashita, and Y. Nagata -- Renal cryoablation / K. Nakagawa and M. Murai -- Prostate cryoablation / B.J. Donnelly and J.C. Rewcastle -- Tumor control outcome and tolerance of permanent interstitial implanation for patients with clinically localized prostate cancer / Y. Nasu, F. Abarzua, and H. Kumon.
  • "Despite the "hot topic" status of this subject, there are few book-length resources that cover the subjects presented here in any depth. There is a particular need for high-quality coverage of hybrid techniques, which have emerged only over the last 3-4 years. Some of the techniques/procedures covered in this book have gained approval and are being used in patient care in Europe and elsewhere and are sure to see approval soon in the United States. Thus, this book not only fills a current need, but also anticipates a very likely near-term need amongst its target audience. The book aims to be a clear, practical guide to the topics covered, and with its combination of text with high-quality still images and videos presented on a companion website it should more than meet the expectations of buyers looking for expert guidance in this area"--Provided by publisher.
  • Part I: Basic MRI Principles.- A Brief History of Magnetic Resonance Imaging -- Fundamentals of Magnetic Resonance Imaging -- The Relaxation Concept in MRI -- MRI Pulse Sequences -- MR Imaging Parameters and Options -- Part II: MR Safety, Patient Positioning, Protocol Design, Graphical Prescription and MR Applications for Anatomical Regions.- Introduction to Safe Clinical Scanning -- Central Nervous System: MRI Protocols, Imaging Parameters and Graphical Prescriptions -- Musculoskeletal Imaging: MRI Protocols, Imaging Parameters and Graphical Prescriptions -- Body Imaging: MRI Protocols, Imaging Parameters and Graphical Prescriptions -- Cardiovascular Imaging: MRI Protocols, Imaging Parameters and Graphical Prescriptions -- Breast Imaging: MRI Protocols, Imaging Parameters and Graphical Prescriptions.
  • Endovascular neurosurgery is a recently introduced but rapidly evolving medical field, which uses minimally invasive interventions to treat major life-threatening vascular lesions of the Central Nervous System. Although its history counts less than 15 years of worldwide acceptance, it has rapidly displaced the traditional open neurosurgical techniques, being nowadays the first treatment choice for brain aneurysms and vascular malformations. Thus, the experience of each neuroendovascular center and performer is invaluable, offering the base for learning and teaching the new generation of interventionalists as well as for the evolvement of the method itself. This book presents the basic principles of endovascular neurosurgery starting from clinical cases. Through this close-to-clinical-reality-process, the reader will be able to more thoroughly understand the pathophysiology of the brain and spine vascular lesions as well as the decision-making strategy, related to the indications, endovascular methods and results, finding suggestions and solutions to his/her clinical questions and problems. Besides chapters devoted to CNS vascular embryology and anatomy, clinical cases organized in groups based on the treated lesions are introduced: ruptured and unruptured cerebral aneurysms of the anterior and posterior circulation, side-wall and bifurcation aneurysms, arteriovenous malformations (AVM), dural arteriovenous fistulae (dAVF), arterial stenosis and angioplasty as well as spinal vascular lesions. A separate chapter is devoted to the organization and necessary equipment of the angio room and the department offering neuroendovascular service. This volume will be of interest to neurosurgeons, interventional neuroradiologists, vascular surgeons, neurologists and ICU physicians as well as health care providers who are involved in the diagnosis and management of the vascular lesions of the brain and spine.
  • In the 4th edition, Drs. Wesley S. Moore, Samuel S. Ahn, and a host of experts guide you through the latest developments in this innovative field. New procedures and special features, such as key points and case reviews, help illustrate effective patient care, and new topics such as endoscopic management of aneurismal disease and traumatic injuries review with you the latest endovascular surgical techniques. Broaden your surgical skills with new chapters on endoscopic management of aneurismal disease and traumatic injuries, and review a valuable new section covering the TIPS Procedure for Portal Hypertension, Anesthetic Management for Endovascular Procedures, the Use of Coil Embolization in Endovascular Surgery, and more. An in-depth, core reference on the best practices and techniques in endovascular surgery. Perfect for both the training vascular surgeon who needs a comprehensive view of endovascular surgery as well as a refresher on current techniques and optimal outcomes for the practitioner.
  • Also available: Print – 2002
  • Also available: Print – 2002
  • Energetics of biological macromolecules. Part A-E pt. A-E, 1995-2004.
    pt. B, 1998 ScienceDirect
    pt. C, 2000 ScienceDirect
    pt. D, 2004 ScienceDirect
    pt. E, 2004 ScienceDirect
    Parts [A]-E.
  • Energy balance and cancer v. 1-, 2011-
  • The gastrointestinal track provides one of the distinct systems where multiple malignancies, including adenocarcinoma of the pancreas, esophagus and colon are each associated with obesity. This unique association is covered in this volume of Energy Balance and Cancer from the epidemiologic, biologic and potential etiologic viewpoint. The focus on possible dietary contribution as well as the role of exercise in prevention and therapy is presented in both animal model and patient based studies. Special focus is provided also on the role of genetic mutations and inflammatory pathways as drivers of these obesity related gastrointestinal malignancies. Overall, this volume on Energy Balance and Gastrointestinal Malignancies should be valuable to Epidemiologists, Gastroenterologists and Oncologists, as well as to students and researchers from multiple disciplines interested in understanding and disrupting the association between obesity and cancer.
  • The obesity pandemic continues to increase on a world-wide basis with over 70% of the United States population being either overweight or obese. Hematologic malignancies have recently been identified among the obesity associated malignancies spanning the lifespan from childhood to the elderly and include leukemia, myeloma, lymphoma and others. In addition to the etiologic association between obesity and hematologic malignancies, the presence of obesity has profound effects on therapy by impacting pharmacokinetics of chemotherapeutic agents, dose, adipocyte metabolism and drug distribution. These may be particularly important in hematopoietic stem cell transplantation. Another important aspect of the association of obesity with hematologic malignancies is the increased incidence of obesity in children who successfully complete therapy for acute lymphoblastic leukemia. This and other observations indicate important relations between the hematopoietic systems and fat metabolism. This volume on Energy Balance in Hematologic Malignancies will provide an important volume in this series and a basis for better understanding etiology, mechanisms, therapeutics implications and experimental approaches. This volume of energy balance and cancer will focus on the relation of obesity to hematologic malignancies, the epidemiology, potential mechanisms, and thereapeutic considerations including effects on pharmacologic and physical approaches as well as the delayed effects of therapy on energy balance.
  • Introduction, Energy Balance in Animals -- Energy Balance -- Limits in Energy Expenditure -- Energy Expenditure, Physical Activity, Body Weight and Body Composition -- Extremes in Energy Intake -- Body Weight -- Growth, Growth Efficiency and Ageing -- Modern Man in Line with Wild Mammals.
  • Qi in Asian medicine / Nancy N. Chen -- Flows and blockages in Rwandan ritual and notions of the body / Christopher C. Taylor -- Elemental souls and vernacular qi : some attributes of what moves us / David Mayor -- The anatomical foundations of qi / John L. Stump -- Qi in China's traditional medicine : the example of tuina / Kevin V. Ergil and Marc S. Micozzi -- Qi cultivation in qigong and taiji quan / Gideon Enz -- Qigong theory and research / Amy L. Ai -- The language of qi, quantum physics, and the superimplicate body / F. David Peat -- Qi and the frequencies of bioelectricity / Cyril W. Smith -- Systems theory : trapping and mapping healing with qi / Christopher Low -- The physiology of qi / Hakima Amri and Mones S. Abu-Asab -- Energy and medicine / John A. Ives and Wayne B. Jonas -- What does it mean to practice an energy medicine? / Claire M. Cassidy -- Evidencing energy : experiences in acupuncture and therapeutic bodywork (zero balancing) / Tim Newman -- Eight modalities for working with qi : chakra acupuncture, with qigong, meditation, and the five sources of energy / Gabriel Stux -- Ki in shiatsu / Patrizia Stefanini -- Bioelectricity and qi : a microcurrent approach / Darren Starwynn -- Energy psychology : working with mind-body synergy / Phil Mollon -- Craniosacral biodynamics / Franklyn Sills -- Qi in children / May Loo -- Qigong, taiji quan (tai chi) and HIV : the psychoneuroimmunology connection / Mary Lou Galantino and Laura Muscatello -- Energy-based therapies in neurology : the example of therapeutic touch / Eric Leskowitz -- Qi in chronic fatigue and fibromyalgia / Carolyn McMakin and Peter H. Fraser -- The electrical heart : energy in cardiac health and disease / Alan Watkins -- Themes of qi and a dozen definitions : content analysis and discussion / David Mayor and Marc S. Micozzi.
  • Molecular Physiology of Monogenic and Syndromic Obesities in Humans / Wendy K. Chung and Rudolph L. Leibel -- Leptin Signaling In the Brain / Ofer Reizes, Stephen C. Benoit, and Deborah J. Clegg -- Inactivating Melanocortin-4 Receptor Mutations and Human Obesity / Ya-Xiong Tao -- The Role of Central Melanocortins in Cachexia / Daniel L. Marks -- The Efferent Arm of the Energy Balance Regulatory Pathway: Neuroendocrinology and Pathology / Robert H. Lustig -- Adiponectin: A Multifunctional Adipokine / Kristen Clarke and Robert L. Judd -- The Role of the Gastrointestinal Hormones Ghrelin, Peptide YY and Glucagon-like Peptide-1 in the Regulation of Energy Balance / Ruben Nogueiras, Hilary Wilson, Diego Perez-Tilve and Matthias H. Tschöp -- The Role of Growth Hormone Secretagogues and Ghrelin in Feeding and Body Composition / Cyril Y. Bowers, Blandine Laferrère, David Hurley, and Johannes D. Veldhuis -- Interaction Between Physical Activity and Genetic Factors in Complex Metabolic Disease / Paul W. Franks and Stephen M. Roth -- 11ss-Hydroxysteroid Dehydrogenase Type 1 and Obesity / Roland H. Stimson and Brian R. Walker -- Prader-Willi Syndrome : A Model of Disordered Energy Homeostasis / Andrea Haqq -- Antipsychotic Medication-Induced Weight Gain and Risk for Diabetes and Cardiovascular Disease / John W. Newcomer -- Treatment of Insulin Resistance in Youth: The Role of Metformin / Molly Emott and Michael Freemark -- The Surgical Approach to Morbid Obesity / Edward E. Mason, Mohammad K. Jamal and Thomas O'Dorisio.
  • Print Material
  • The generation of zinc finger proteins by modular assembly / Mital S. Bhakta and David J. Segal -- Engineering single Cys2His2 zinc finger domains using a bacterial cell-based two-hybrid selection system / Stacey Thibodeau-Beganny, Morgan L. Maeder, and J. Keith Joung -- Bipartite selection of zinc fingers by phage display for any 9-bp DNA target site / Jia-Ching Shieh -- Structure-based DNA-binding prediction and design / Andreu Alibés, Luis Serrano, and Alejandro D. Nadra -- Generation of cell-permeable artificial zinc finger protein variants / Takashi Sera -- Inhibition of viral transcription using designed zinc finger proteins / Kimberley A. Hoeksema and D. Lorne J. Tyrrell -- Modulation of gene expression using zinc finger-based artificial transcription factors / Sabine Stolzenburg ... [et al.] -- Construction of combinatorial libraries that encode zinc finger-based transcription factors / Seokjoong Kim, Eun Ji Kim, and Jin-Soo Kim -- Silencing of gene expression by targeted DNA methylation : concepts and approaches / Renata Z. Jurkowska and Albert Jeltsch -- Remodeling genomes with artificial transcription factors (ATFs) / Adriana S. Beltran and Pilar Blancafort -- Transgenic mice expressing an artificial zinc finger regulator targeting an endogenous gene / Claudio Passananti ... [et al.] -- Artificial zinc finger nucleases for DNA cloning / Vardit Zeevi, Andriy Tovkach, and Tzvi Tzfira -- In vitro assessment of zinc finger nuclease activity / Toni Cathomen and Cem Șöllü -- Quantification of zinc finger nuclease-associated toxicity / Tatjana I. Cornu and Toni Cathomen -- A rapid and general assay for monitoring endogenous gene modification / Dmitry Y. Guschin ... [et al.] -- Engineered zinc finger proteins for manipulation of the human mitochondrial genome / Michal Minczuk -- High-efficiency gene targeting in Drosophila with zinc finger nucleases / Dana Carroll, Kelly J. Beumer, and Jonathan K. Trautman -- Using zinc finger nucleases for efficient and heritable gene disruption in zebrafish / Jasmine M. McCammon and Sharon L. Amacher -- A transient assay for monitoring zinc finger nuclease activity at endogenous plant gene targets / Justin P. Hoshaw ... [et al.] -- Validation and expression of zinc finger nucleases in plant cells / Andriy Tovkach, Vardit Zeevi, and Tzvi Tzfira -- Non-FokI-based zinc finger nucleases / Miki Imanishi, Shigeru Negi, and Yukio Sugiura -- Designing and testing chimeric zinc finger transposases / Matthew H. Wilson and Alfred L. George -- Seeing genetic and epigenetic information without DNA denaturation using sequence-enabled reassembly (SEER) / Jason R. Porter ... [et al.] -- Zinc finger-mediated live cell imaging in Arabidopsis roots / Beatrice I. Lindhout, Tobias Meckel, and Bert J. van der Zaal -- Biophysical analysis of the interaction of toxic metal ions and oxidants with the zinc finger domain of XPA / Andrea Hartwig, Tanja Schwerdtle, and Wojciech Bal -- Preparation and zinc-binding properties of multi-fingered zinc-sensing domains / John H. Laity and Linda S. Feng -- Using ChIP-seq technology to identify targets of zinc finger transcription factors / Henriette O'Geen, Seth Frietze, and Peggy J. Farnham -- Crystallization of zinc finger proteins bound to DNA / Nancy C. Horton and Chad K. Park -- Beyond DNA : zinc finger domains as RNA-binding modules / Josep Font and Joel P. Mackay.
  • Evolution has selected for organisms that benefit from genetically encoded cell-cell communication. We observe cell-cell communication throughout every scale in nature, from simple single-celled bacteria to complex multicellular mammals. Engineers have begun to repurpose elements of natural communication systems to coordinate their own population-level behaviors, including oscillations and programmed pattern formation. Existing engineered systems, however, rely on small, system-specific biomolecules to send messages among cells. However, such molecules are capable of sending only a single message, typically "regulate transcription.'' Thus, the information transmission capacity of such biological communication systems is fundamentally limited. Through this thesis, I demonstrated the decoupling of messages from a common communication channel via the autonomous transmission of numerous arbitrary genetic messages. To do so, I engineered a cell-cell communication platform using bacteriophage M13 gene products to autonomously package and deliver heterologous DNA messages of varying lengths and encoded functions. Further, I increased the range of engineered DNA messaging across semisolid media by coupling message transmission or receipt to active cellular chemotaxis. Through this coupling, I demonstrated that our system is adaptable to different contexts by creating simple patterns. Finally, using recombinase-mediated logic gates developed within the Endy laboratory, I demonstrated the ability to program bacteria by transmitting logic gates to surrounding cells. Overall, this work significantly enhances the suite of cell-cell communication tools available to engineers. I have shown that a variety of DNA messages can be transmitted among cells and have moved the field of synthetic biology closer to designing synthetic ecologies with more complex communication schemes and varied behaviors.
  • Proteins and peptides are an incredibly versatile class of biological molecules, with a vast array of naturally occurring functions. In cancer, the natural roles of proteins become incorrectly regulated, and the presence of cancer-related proteins on tumor cells can be detected and targeted for diagnosis and treatment. This thesis decribes novel engineered peptides for molecular recognition of cell surface receptors expressed in cancers, and application of these engineered peptides as diagnostic agents to identify solid tumors in mouse models. For this work. three different cystine-knot peptides were used for development and engineering: Agatoxin (AgTx), Agouti-related protein (AgRP), and Ecballium elaterium trypsin inhibitor-II (EETI). In addition, two protein receptors were employed as model tumor targets relevant for molecular imaging of cancer: carbonic anhydrase IX (CA IX) and tumor associated integrin receptors. New methods were developed towards engineering AgTx and AgRP to bind CA IX, and work to produce these peptides for further study and their limitations are described. In a parallel line of research, to further understand the promise of using knottin peptides in cancer imaging, the influence of amino acid loops on tissue biodistribution was examined using engineered AgTx, AgRP, and EETI peptides that bind tumor target integrins in mouse xenograft models. Finally, an engineered EETI knottin peptide that binds tumor-associated integrins was shown to specifically target and illuminate brain tumors in mouse models of medulloblastoma. Importantly, the protein engineering methods and molecular imaging applications described here have promise for influencing the clinical outcome of cancer patients through image-guided surgical resection, disease staging and management, and monitoring the effectiveness of therapeutic treatments.
  • Polyketides are a large class of structurally diverse natural products which posses a wide range of biological activities. Unfortunately, despite the potential utility of these compounds in the clinic, large scale production of many of these natural products from their native hosts remains a challenge. Additionally, due to their complexity, engineering better pharmacokinetic properties by traditional synthetic means is often challenging. A better understanding of the biosynthetic machinery which produces polyketides allows for optimization of their production and paves the way for bioactivity-based pathway reengineering. This work begins with an introduction detailing attempts to unravel the biosynthetic underpinnings of two key natural product families, the tetracyclines and the thiostreptons, with an eye toward ultimately reengineering the pathways. Then, our efforts to reconstruct and reengineer the biosynthesis and biological activity of the type II polyketides frenolicin and A-74528 are detailed. Successful reconstruction of a chimeric biosynthetic pathway to frenolicin B and subsequent reengineering of that pathway to produce novel frenolicin analogs is described. Then, the biological activity of these compounds both in vitro against the parasites Toxoplasma gondii and Plasmodium falciparum is discussed. Additional studies against Plasmodium berghi in mice show that frenolicin B is an effective antiparastic agent in vivo. Following this, engineering of a biosynthetic pathway to the novel antiviral agent A-74528 from S. sp. SANK 61196 is presented and the impact of various tailoring enzymes on metabolite production are explored.
  • Recombinant proteins have been used widely in both basic research and biomedical applications including protein therapeutics and biomaterials. Many efforts have been devoted to the investigation of novel synthetic strategies for producing recombinant proteins for various applications, which is the focus of this dissertation. In the first section, a biosynthetic strategy was developed to produce collagenous proteins with post-translational modifications in E. coli. Collagen is the most abundant protein in human, and plays a dominant role in maintaining the biological and structural integrity. Recombinant expression of collagens and fragments of collagens is often difficult as their stability requires appropriate proline hydroxylation. Prolyl 4-hydroxylases (P4H) are ascorbate-dependent oxygenases that play key roles in collagen folding by catalyzing the post-translational hydroxylation of specific proline residues on target proteins to form (2S, 4R)-4-hydroxyproline. Thus far, the study of these post-translational modifications has been limited by the lack of a prokaryotic recombinant expression system for producing hydroxylated proteins. Unlike eukaryotic cells such as yeast and insect cells, bacterial cytoplasm cannot activate P4H, which requires an ascorbate co-factor that bacteria do not produce. By introducing a biosynthetic shunt to produce ascorbate-like molecules in E. coli cells that heterologously express human P4H, we have created a strain of E. coli that produces collagenous proteins with (2S, 4R)-4-hydroxyproline. Different levels of proline hydroxylation can be obtained by tuning culture conditions. We have verified that hydroxylation of collagenous materials produced in the new system leads to an increase in thermostability. Using this new system, we have observed hydroxylation patterns indicative of a processive catalytic mode for P4H that is active even in the absence of ascorbate. Our results provide insights into P4H enzymology, and create a foundation for better understanding how post-translational hydroxylation affects proteins. Further, we applied the novel E. coli expression system to produce a collagenous protein, adiponectin, which has many beneficial effects on obesity-related metabolic and cardiovascular disorders, and reverses insulin insensitivity. By introducing key post-translational modification enzymes to E. coli, we have endowed the expression system with capabilities of making necessary modifications on adiponectin for its correct assembly, and thus obtained biomimetic adiponectins. High-molecular weight (HMW) multimers of adiponectin have been obtained, and their biological activities of suppressing endothelial cell apoptosis have been confirmed with in vitro cell assays. In section 2, modular protein polymers have been created through genetic engineering and enzymatically crosslinked into hydrogels with tunable properties. The many challenges currently faced in regenerative medicine research require the development of new, modular biomaterial systems that can serve as scaffolds for cellular maintenance, expansion and growth, and which can be tuned by the user to mimic any necessary aspects of natural ECM to an optimal degree. Toward this goal, we have created a family of block co-polypeptides comprising amino acid sequence elements that allow mild enzymatic crosslinking into gels. These new families of protein polymers were designed to be linear, random coil, and contain either lysine or glutamine, which have the recognition substrates for transglutaminase (TG) crosslinking, evenly spaced along the protein backbone. Crosslinking occurred within two minutes upon the addition of TG under physiological conditions, as determined by particle tracking microrheology. The material properties of the gel can be tuned with the hydrogel composition to mimic cellular microenvironment of different tissues. Furthermore, in order to introduce biofunctionalities into the hydrogels, a versatile expression vector has been engineered that allows the insertion of bioactive protein domains into these block co-polypeptide. For example, a cell adhesion signal based on the RGD sequence from human fibronectin was incorporated. The RGD-containing hydrogel was successful in enhancing cell adhesion, and were also proven to be compatible with the culture of mesenchymal stem cells. The specific nature of these protein polymer precursors of the modular hydrogel composition allows tailoring of mechanical and biochemical properties, rendering these gels valuable for various tissue engineering applications.
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  • Memory Enhancement Strategies: What Works Best for Obtaining Memory Goals? -- Mental and Physical Exercise as a Means to Reverse Cognitive Aging and Enhance Well-Being -- Consumer-Based Brain Fitness Programs -- Synapse: A Clinical Trial Examining the Impact of Actively Engaging the Aging Mind -- Meditation, Mindfulness, Cognition, and Emotion: Implications for Community-Based Older Adult Programs -- Keys to a Sharp Mind: Providing Choice and Quality Programming in a Retirement Community -- Osher Lifelong Learning Institute at the University of Montana: A Model of Successful University and Community Partnerships -- Closing the Generation Gap: Using Discussion Groups to Benefit Older Adults and College Students -- A Practical Guide to Senior Odyssey -- Spelling Clubs and Competitions for Older Adults: Language Boosting Within a Social Context -- Oral Life Review in Older Adults: Principles for the Social Service Professional -- Creative Writing Groups: A Promising Avenue for Enhancing Working Memory and Emotional Well-Being -- Peer-Led Memory Training Programs to Support Brain Fitness -- Cognitive Wellness for Diverse Populations -- The Role of Physical Activity in Cognitive Fitness: A General Guide for Community Programs -- Nutrition and Nutritional Supplements to Promote Brain Health -- Enhancing Healthy Cognitive Aging Through Theater Arts -- Coming Alive: Kairos Dance Theatre's Dancing Heart[TM] - Vital Elders Moving in Community -- Art, Museums, and Culture -- The Songwriting Works[TM] Model: Enhancing Brain Health and Fitness Through Collaborative Musical Composition and Performance -- Supporting Cognition and Well-Being in Older Adults with Mild Cognitive Impairment: A Pilot Intervention -- Early Memory Loss Clubs: A Novel Approach for Stimulating and Sustaining Cognitive Function -- Implementing the "I'm Still Here"[TM] Approach: Montessori-Based Methods for Engaging Persons with Dementia -- Kirtan Kriya Meditation: A Promising Technique for Enhancing Cognition in Memory-Impaired Older Adults -- Brain Brightening: Neurotherapy for Enhancing Cognition in the Elderly -- Neurons in Neighborhoods: How Purposeful Participation in a Community-based Intergenerational Program Enhanced Quality of Life for Persons Living with Dementia -- Experience Corps®: A Civic Engagement-Based Public Health Intervention in the Public Schools.
  • Rationale for developmental interventions in children -- Enhancing childhood development in a normal child -- Enhancing childhood development in children with autism -- Enhancing childhood development in children with cerebral palsy and other disorders -- Enhancing childhood development in children with behavioral and psychological disorders -- Nutrition for better development -- Summary of the "Care for Childhood Development" program (UNICEF/WHO).
  • Enhancing Medication Adherence: The Public Health Dilemma is a comprehensive guide to medication adherence for the healthcare professional. Clinicians and pharmacists alike can benefit from key opinion leader and author Hayden Bosworth's text as he explains the details and causes behind medication nonadherence as well as methods on how healthcare providers can determine if a patient is nonadherent. Additionally, Bosworth discusses various studies, which assess adherence, adherence-related technology, best practices for clinicians and pharmacists, and future directions and recommendations in the field.
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    Introduction to the guidelines. Purpose, target and scope -- Background -- A dual obligation, a quadruple imperative -- Indispensability of controlled medicines in contemporary medical practices -- Safety of controlled medicines -- Current availability -- Impediments to availability, accessibility and affordability -- Why and how to work with this document? -- Guidelines for ensuring balance in national policies on controlled substances. Content of drug control legislation and policy -- Authorities and their role in the system -- Policy planning for availability and accessibility -- Healthcare professionals -- Estimates and statistics -- Procurement -- Other -- Country assessment checklist.
  • 1. Grommet insertion -- 2. Removal of lesion from pinna : wedge excision -- 3. Excision of preauricular sinus -- 4. Myringoplasty -- 5. Ossiculoplasty -- 6. Stapedotomy -- 7. Mastoidectomy and canalplasty -- 8. Cochlear implantation -- 9. Manipulation under anaesthesia of fractured nose -- 10. Septoplasty -- 11. Surgery to inferior turbinates -- 12. Endoscopic sphenopalatine artery ligation -- 13. Anterior ethmoidal artery ligation -- 14. Functional endoscopic sinus surgery (FESS) -- 15. Septorhinoplasty -- 16. Lateral rhinotomy and medial maxillectomy -- 17. Maxillectomy -- 18. Endoscopic dacryocystorhinostomy -- 19. External carotid artery ligation -- 20. Midfacial degloving -- 21. Fine needle aspiration cytology -- 22. Lymph node biopsy -- 23. Tonsillectomy and adenoidectomy -- 24. Uvulopalatoplasty -- 25. Tracheostomy -- 26. Diagnostic procedures in the upper aerodigestive tract -- 27. Paediatric microlaryngoscopy and bronchoscopy (MLB) foreign body removal -- 28. Phonosurgery -- 29. Microlaryngoscopy and laser use -- 30. Pharyngeal pouch -- 31. Submandibular gland excision -- 32. Superficial parotidectomy -- 33. Thyroglossal cyst excision -- 34. Thyroidectomy -- 35. Neck dissection -- 36. Total laryngectomy -- 37. Pectoralis major myocutaneous flap -- 38. Local flaps -- 39. Pinnaplasty -- 40. Blepharoplasty -- 41. Face lift.
  • ENT Board Prep is a high-yield review that is an ideal study guide for the ENT in-service and board exams. While other review guides are low yield or more of a textbook, this is quick, concise, and easy-to-use, providing everything you need to know in a easy to digest format. ENT Board Prep offers review on sections such as cancer, ear, sinus, plastics, sleep, and laryngology, as well as case studies useful for studying for the oral board exams. Written and edited by leaders in the field, this book aims to serve future residents and fellows in those crucial weeks leading up to the ENT board exam.
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    The enteric plexuses -- Interconnections between the plexuses -- Extent of the ganglionated plexuses -- Intramural extensions of extrinsic nerves -- Electron microscope studies -- Enteric glia -- The structural similarities and functional differences between regions may have an evolutionary basis -- Development of the enteric nervous system -- Maturation of enteric neurons and development of function -- Changes in enteric neurons with aging -- Summary and conclusions -- Shapes of enteric neurons -- Cell physiological classifications of enteric neurons -- Functionally defined enteric neurons -- Neurons in human intestine with equivalence to those investigated in laboratory animals -- Summary and conclusions -- Evolution of ideas about enteric circuitry -- Motility controlling circuits of the small and large intestine -- Intrinsic secretomotor and vasomotor circuits -- Assemblies of neurons -- Circuits in the esophagus and stomach -- Co-ordination of motility, secretomotor and vasomotor reflexes -- Circuits connecting the intestine, biliary system and pancreas -- Sympathetic innervation of the gastrointestinal tract -- Summary and conclusions -- Chemical coding and multiple transmitters -- Transmitters of motor neurons that innervate the smooth muscle of the gut -- Transmitters at neuro-neuronal synapses -- Sites within the reflex circuitry where specific pharmacologies of transmission can be deduced to occur -- Transmission from entero-endocrine cells to IPANs -- Roles of interstitial cells of Cajal in neuromuscular transmission -- Transmitters of secretomotor and vasodilator neurons -- Synapses in secretomotor and vasodilator pathways -- Transmitters of motor neurons innervating gastrin cells -- Summary and conclusions -- Rhythmic activity of gastrointestinal muscle -- Structure and properties of interstitial cells of cajal -- Relationship between slow wave activity and neural control -- Gastric motility -- Patterns of small intestine motility and their intrinsic neural control -- Motility of the colon -- Neural control of the esophagus -- Gall-bladder motility -- Sphincters -- Muscle of the mucosa -- Mechanism of sympathetic inhibition of motility in non-sphincter regions -- Sympathetic innervation of the sphincters -- Physiological effects of noradrenergic neurons on motility in undisturbed animals -- Reflex activities of sympathetic neurons that affect motility -- Summary and conclusions -- Water and electrolyte secretion in the small and large intestines -- Reflex control of water and electrolyte secretion -- Secretion of gastric acid -- Pepsinogen secretion -- Gastric secretion of bicarbonate -- Secretion into the gall bladder -- Pancreatic exocrine secretion -- Summary and conclusions -- Therapeutic endpoints for motility disorders -- Therapies for secretory diarrheas -- Enteric neuropathies involving neuronal loss or phenotypic changes -- Mitochondriopathies with intestinal manifestations -- Irritable bowel syndrome and plasticity of enteric neurons -- Summary and conclusions.
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    Enterobacter sakazakii and Salmonella are the primary pathogens of concern with regard to powdered infant formula. Guidance for the control of these hazards is currently being developed by Codex Alimentarius through the revision of the Recommended International Code of Hygienic Practices for Foods for Infants and Children. FAO and WHO are providing the scientific advice to facilitate this work. FAO and WHO implemented the first meeting on this issue in 2004, the outcome of which is reported in number six of this series. This report builds on the information and advice provided in 2004.
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    This report provides a review of commented Entrobacter sakazakii (Cronobacter spp.) infections worldwide in infants and young children as well as the existing surveillance systems and their capacity to capture cases of E. sakazakii (Cronobacter spp.) infection.--Publisher's description.
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  • Entomology. 3rd ed. 2005
  • Also available: Print – v. 1, 1922.
  • This thesis examines three topics that are related to the Gram-positive bacterial cell envelope. First, I examine how transmembrane proteins navigate through the thick, heavily cross-linked Gram-positive cell wall while remaining anchored to the bacterial membrane. I develop a theoretical model that predicts that entropic confinement of a disordered protein can drive translocation through the cell wall. I experimentally test important predictions of the model to demonstrate that translocation depends on the length of the translocating protein and the geometry of the bacterial surface, while demonstrating that entropy-driven translocation occurs in a variety of Gram-positive species. Second, I study how the antimicrobial peptide nisin causes cell death in Gram-positive bacteria. I demonstrate that nisin treatment triggers membrane collapse in multiple Gram-positive species, and provide evidence that collapse is initiated by an increase in compressive stress in the membrane. Finally, I examine the process of cell division in the Gram-positive coccus Staphylococcus aureus. Contrary to the current view of S. aureus division, cell volume increases monotonically during the cell cycle, as opposed to occurring entirely during cell separation. I observed a dramatic millisecond hemisphere-to-sphere transition during cell separation that was accompanied by a decrease in surface area, suggesting that separation is associated with a redistribution of cell wall stress.
  • "Enumerating Invisibility, Humanizing Numbers: Public Health and the Production of Inequities 1938-1974" is directed at answering one question: Why in spite of intensive study that has resulted in a wealth of numerical and statistical information on public health does the San Joaquin Valley and the residents therein remain, among one of the most underfunded, overlooked, impoverished and unhealthy regions? Through an examination of historical materials-- surveys, reports, occupational surveillance, and decision making-- this dissertation seeks to better understand how data and policy, through the social processes of classification and quantification, may have contributed to the production of inequities in the San Joaquin Valley. There are few studies to date that systematically examine the relationship between knowledge and numbers and even fewer that address the concerns of frequently overlooked communities of agricultural laborers in the San Joaquin Valley. This dissertation begins to fill these gaps by reviewing a diverse array of source material to trace how institutions counted and measured agricultural laborers, how the institutions shaped these counting practices, and how numbers shaped policies. Given that institutional identities and strategies of governance are at stake in the production of these numbers, the story of agricultural laborers their health, social, and scientific visibility must be told alongside the stories of state bureaucracies. In tracing how institutions counted and measured agricultural laborers, how the institutions shaped these counting practices, how numbers shaped policies and decisions, there is an opportunity to understand historically the potential consequences of these counting practices. Together they reveal how institutional identities contributed to the making of public health data-- its production, content and interpretation. This data, meant to reveal patterns of disease and improve public health, has paradoxically played a role in concentrating health inequities in the San Joaquin Valley because it has often made invisible the relationships between material deprivation and health or the environment and health. This dissertation does not advocate that we cease to use numbers in science and in policy. Rather, it is meant to recognize that every system of data collection and surveillance, regardless of the institution producing the data, is subjective and is shaped by particular values that have material consequences on populations As a result, the analysis intends to render numbers and their production more transparent and therefore open to critical analysis, and to provoke reflection on how the human elements- history, culture, and experiences --can explain the inequities that data alone can conceal.
  • Epidemiologic basis of the role of environmental endocrine disruptors in breast cancer / Robert A. Hiatt -- Puberty as a window of susceptibility / Frank M. Biro and Mary S. Wolff -- In search of the optimal experimental model / Irma H. Russo and Jose Russo -- Early life exposure to bisphenol A and breast neoplasia / Maricel V. Maffini, Carlos Sonnenschein, and Ana M. Soto -- Endocrine disruptors affect the genomic profile of the rat mammary gland at different developmental stages / Ricardo Lopez de Cicco ... [et al.] -- Proteomic basis for the increased susceptibility of the mammary gland to carcinogenesis after perinatal exposure to bisphenol A / Sarah Jenkins ... [et al.] -- Dioxin as an environmental pollutant and its role in breast cancer / Stephen Safe, Kelcey Walker, and Shu Zhang -- Mammary gland as a sensitive tissue to developmental exposures of perfluorooctanoic acid (PFOA) in the mouse / Sally S. White ... [et al.] -- Atropine : an environmental endocrine disruptor that alters mammary gland development and tumor susceptibility / Jennifer L. Rayner and Suzanne E. Fenton -- Biological impact of radiation exposure on breast cancer development / David H. Nguyen, Irineu Illa Bochaca, and Mary Helen Barcellos-Hoff -- Brain estrogens and metabolism / Yong Xu and Deborah J. Clegg.
  • Also available: Print – 2015
    The impairment of lung function caused by environmental exposure to pollutants and toxicants is a rising health problem, particularly in highly industrialized parts of the world. The problem is urgently calling for the development of new methodologies to assess both the level of elemental exposure and the effects for quality of health and longevity. This volume provides state-of-the-art information about the recent advances in occupational and non-occupational pollutant-related disorders of the respiratory tract, and the assessment of a threat they pose for the health-span. Heavy traffic-related air pollution, unnoticeable but salient health detriment, is dealt with at length.
  • Discipline of environmental and occupational medicine / William N. Rom -- The Role of surveillance in occupational health / Steven B. Markowitz -- The Occupational and environmental history and examination / John E. Parker -- Epidemiology of occupational diseases / Gary M. Marsh -- Occupational biostatistics / Howard E. Rockette -- Impairment, disability, and functional capacity / Alan L. Engelberg and William Greaves -- Molecular biology / John G. Hay -- TP53 tumor suppressor gene / S. Perwez Hussain and Curtis C. Harris -- Biomarkers / Sudhir Srivastava and Karl E. Krueger -- Genetic susceptibility / Chu-Ling Yu and David C. Christiani -- Environmental mutagenesis / C. Stuart Baxter -- Evaluation of occupational exposures and effects on male and female reproduction / Susan Rae Reutman and Grace K. LeMasters -- Particle deposition and pulmonary defense mechanisms / Morton Lippmann and Lung-chi Chen -- Lung immune defenses against environmental agents / Lester Kobzik -- Pulmonary function testing / Stuart M. Garay -- Imaging of pneumoconioses / David A. Lynch -- Molecular mechanisms of particle-induced lung disease / Arnold R. Brody and Gilbert F. Morris -- Analysis of fibrous and nonfibrous particles / Jerrold L. Abraham and Bryan R. Burnett -- Asbestosis, pleural fibrosis, and lung cancer / William N. Rom -- Malignant mesothelioma / Delia Nelson ... [et al.] -- Man-made vitreous fibers, vermiculite, and zeolite / James E. Lockey, Vikas Kapil, and Nancy K. Wiese -- Respiratory disease in coal miners / Michael D. Attfield, Vincent Castranova, and Gregory R. Wagner -- The Health effects of silica exposure / Ahmad S. Jalloul and Daniel E. Banks -- Hypersensitivity pneumonitis / Yvon Cormier and Yves Lacasse -- Inhalation fever / Paul David Blanc -- Occupational and environmental asthma / Stuart M. Brooks, Thomas Truncale, and James McCluskey -- Environment, genes, and immune mechanisms in asthma / Joan Reibman, Linda Rogers, and Maria Elena Fernandez-Beros -- Firefighter's health and health effects of the world trade center collapse / Michael Weiden ... [et al.] -- International byssinosis / Denise Harrison -- Isocyanates exposures and health effects / Carrie Redlich and Dhimiter Bello -- Occupational exposures as a cause of chronic airways disease / John R. Balmes -- Lung Diseases associated with silicates and other dust / Vinicius Antao, Germania Pinheiro, and John E. Parker -- Respiratory tract irritants / Tee Guidotti -- Simple asphyxiants / Marc Wilkenfeld -- Chemical asphyxiants / William S. Beckett -- Agricultural dust-induced lung disease / M. Brian Hartz, Nancy Sprince, and Joel Kline -- Upper airway disorders / Rebecca Bascom and Marina Y. Dolina -- Occupational skin disease / David Cohen and Megan M. Moore -- Toxic peripheral neuropathy / Margit L. Bleecker -- Human behavioral neurotoxicology / W. Kent Anger, Diane S. Rohlman, and Daniel Storzbach -- Occupational heart disease / Kenneth D. Rosenman -- Occupational eye disorders / Jason A. Goldsmith, Norman A. Zabriskie and Randall J. Olson -- Occupational infections / Kevin Dieckhaus -- Terrorism preparedness / Lewis Goldfrank and Howard Greller -- HIV in the workplace / Marty Markowitz ... [et al.] -- The Occupational risk of tuberculosis care / Kent A. Sepkowitz and Tara Palmore -- Hematologic effects of occupational hazards / John H. Ward -- Toxic liver disorders / John D. Groopman and Denise Johnson -- Environmental and occupational causes of toxic injury to the kidneys and urinary tract / Edward T. Zawada, Jr. -- Occupational bladder cancer / Steven B. Markowitz -- Psychiatric syndromes common to the workplace / Robert C. Larsen -- Alcohol and drug abuse in industry / Kent W. Peterson and Donna R. Smith -- Psychological job stress / Joseph J. Hurrell, Jr. -- Multiple chemical sensitivity / Alan M. Ducatman -- Gulf war illness / Howard Kipen and Melissa McDiarmid -- Occupational safety and human factors / Howard Sandler -- Ergonomics and occupational biomechanics / Manny Halpern -- Nonspecific low back pain / Margareta Nordin -- Carpal tunnel syndrome / Owen Kieran -- Toxicogenomics and exposure assessment / Samuel Wilson ... [et al.] -- Occupational and environmental exposure to lead / Alf Fischbein and Howard Hu -- Mercury / Lynn Goldman -- Cadmium / Dominique F. Lison and Violaine Verougstraete -- Arsenic / Toby G. Rossman -- Beryllium disease / Lisa A. Maier, Carol Gunn and Lee S. Newman -- Hard metal disease / Dominique F. Lison -- Chromium compounds / Mitchell D. Cohen and Max Costa -- Nickel compounds / Mitchell D. Cohen, Catherine Klein and Max Costa -- Metal compounds and rare earths / Bruce Fowler -- Organic solvents and fuels / Nancy L. Fiedler and Steven Lerman -- Benzene / Philip J. Landrigan -- Formaldehyde / Dean B. Baker -- Ethylene oxide / Anthony D. LaMontagne, N. Kyle Steenland and Karl T. Kelsey -- Pesticides / Marc B. Schenker, Steven R. Offerman, and Timothy E. Albertson -- Health effects of agent orange, other military herbicides, and dioxins / Jeanne M. Stellman and Steven D. Stellman -- Pentachlorophenol and tetrachlorophenol / Glenys M. Webster, Shona J. Kelly and Kay Teschke -- Polychlorinated biphenyls / Stephen H. Safe -- Trimellitic anhydride and other acid anhydrides / Leslie C. Grammer and Kathleen E. Harris -- Carbon disulfide / Stephen M. Levin and Ruth Lilis -- N Nitrosamines / Stephen S. Hecht -- Polycyclic aromatic hydrocarbons and petroleum industry / Steven D. Stellman and Tee L. Guidotti -- Occupational hazards in the microelectronics industry / Joseph LaDou -- Radiation carcinogenesis / Fred Burns ... [et al.] -- Nonionizing radiation / W. Gregory Lotz -- Occupational exposure to noise / Robert J. McCunney and John Meyer -- Dysbarism / Rafael E. de la Hoz -- High-altitude illnesses / William N. Rom -- Thermal extremes in the work environment / Kathleen A. Delaney and Lewis R. Goldfrank -- Occupational exposure to vibration / Donald E. Wasserman and Jack Wasserman -- Shift work and long work hours / Claire Caruso and Roger R. Rosa -- Sleep disorders and work / Joyce A. Walsleben, Edward B. O'Malley, and David M. Rapoport -- Sick building syndrome and building-related illness / Kathleen Kreiss -- Air pollution : outdoor and indoor sources / George D. Thurston -- Air pollution : epidemiology / Johnathan Samet -- Air pollution : human health studies / Robert B. Devlin and Donald Graff -- Air pollution : toxicological studies / Terry Gordon -- Ozone / Morton Lippmann -- Nitrogen oxides / Richard Schlesinger -- Sulfur dioxide / Mark Frampton and Mark J. Utell -- Particulate matter / Sverre Vedal and Jeffrey H. Sullivan -- Acid rain / Kathleen C. Weathers, Gene E. Likens, and Thomas J. Butler -- Cigarette smoking / Jonathan Samet and Stephen S. Hecht -- Bioaccumulation and toxicities of aromatic hydrocarbon contaminants at different trophic levels of the Hudson River ecosystem / Isaac I. Wirgin -- The Built environment / Howard Frumkin -- Biological and medical implications of global warming / Paul R. Epstein -- Chlorofluorocarbons and destruction of the ozone layer / Mario J. Molina and Luisa T. Molina -- Environmental law and policy / Jeffrey G. Miller -- Clean Air Act / Daniel Greenbaum -- Occupational Safety and Health Administration and the National Institute for Occupational Safety and Health / John Howard -- United States Environmental Protection Agency / Kathleen Callahan ... [et al.] -- Environmental health practice and research at the Centers for Disease Control and Prevention and the Agency for Toxic Substances and Disease Registry / Thomas H. Sinks and Henry Falk -- Risk assessment and economic evaluation / James Hammitt -- Workers' compensation / Nicholas A. Ashford -- International occupational and environmental health / Joseph LaDou -- Children's environmental health research / Frederica Perera and Sheila Viswanathan -- Disparities in environmental and occupational health / George Friedman-Jiménez and Luz Claudio -- Industrial hygiene measurement and control / Beverly S. Cohen -- Respirators / Philip Harber -- The Occupational health service / Peter Rabinowitz and Oyebode Taiwo -- Moral questions of occupational and environmental medicine / Sheldon Samuels -- New frontiers in environmental health research / David A. Schwartz, Brenda K. Weis, and Samuel H. Wilson.
  • Also available: Print – 2015
    The book presents the latest advances in research into health effects of air pollution, with heavy motor vehicle traffic or cigarette smoke as the exemplar of pollution. The airways are the first-line defense system against pollution. The book focuses on respiratory ailments underlain by inflammation, increased susceptibility to infection, particularly acquired during harsh environmental conditions and exposures to particulate matter or pathogens. The importance of astute analysis of lung function for early diagnosis of disorders is underscored. A knowledge deficit concerning the aerosolized drug delivery through the airways also is addressed. Recent developments and viewpoints in the field of environmental health hazards as well as methodological advances in their assessment are provided. The book will be of interest to pulmonologists, healthcare providers, researchers and clinicians engaged in environment-related respiratory diseases, but also to policy makers concerned with clean ambient air quality.
  • The capacity of the epigenome to interpret both internal and external stimuli and alter expression programs is a critical component in normal development, aging, and disease pathogenesis. In the past decade, we have witnessed an explosion of unprecedented research on and support for epigenetics, epigenomics, and their interface with human health and disease. In this volume, Environmental Epigenomics in Health and Disease - Epigenetics and Complex Diseases, a number of leading investigators in the field of epigenetics discuss patterns of epigenomic modifications in normal cells, and how environmentally-induced changes in them are associated with disease pathogenesis. The authors comprehensively review the epigenetic adaptations that occur in human embryonic stem cells, as well as in differentiating cells and organs such as the brain when exposed to environmental factors, and discuss the legal and ethical implications of such alterations. The overall purpose of this volume and its companion, Environmental Epigenomics in Health and Disease - Epigenetics and Disease Origins, is to give readers an overview of how environmental exposures during early development can influence disease formation by disrupting epigenetic programming.
  • Exposure to environmental toxicants is associated with changes in DNA methylation and gene expression profiles that together can contribute to increased disease susceptibility. The chapters in this volume, Environmental Epigenomics in Health and Disease - Epigenetics and Disease Origins, address a wide range of environmental exposures, such as airborne particulates, cocaine, radiation, tobacco smoke, and xenoestrogens. Particular emphasis is placed on the consequences of environmental exposures during development on epigenetic reprogramming that influences adult disease pathogenesis. Health outcomes associated with these exposures include autoimmune disorders, neurodevelopmental disorders, and cancer. Importantly, dietary supplements and drugs can modify the epigenetic effects induced by these agents, thereby reducing their toxicological impact. The overall purpose of this volume and its companion, Environmental Epigenomics in Health and Disease - Epigenetics and Complex Diseases, is to give readers an overview of how environmental exposures during early development can influence disease formation by disrupting epigenetic processes and developmental programming.
  • Part 1. General Principles -- Introduction / Deodutta Roy and M. Tevfik Dorak -- Gene-Environment Interactions, Phenotypic Changes, and Human Health / Rosemarie G. Ramos and Kenneth Olden -- Statistics for Testing Gene-Environment Interaction / Momiao Xiong and Xuesen Wu -- Clustering Studies for Identifying the Role of Environmental Factors in Aetiology of Human Cancers / Richard J.Q. McNally -- Discovering Gene-Gene and Gene-Environment Causal Interactions Using Bioinformatics Approaches / Changwon Yoo -- Gene Environment Interactions and Vascular Lesions / Quentin Felty -- Epigenetic Changes in Cancer: Role of Environment / Zdenko Herceg and Paolo Boffetta -- Approaches to Identify Environmental and Epigenomic Components or Covariates of Cancer and Disease Susceptibility / Alok Deoraj and Deodutta Roy -- Part 2. Environment and Specific Types of Cancer -- Gene-Environment Interaction and Susceptibility to Pediatric Brain Tumors / Brian Kunkle, David Sandberg, Prasanna Jayakar, Quentin Felty and Deodutta Roy -- Genetic Polymorphisms Predisposing Individuals to Breast Cancer Via Gene-Environment Interaction / Keun-Young Yoo, Sue K. Park and Aesun Shin -- Environment, Genetic Immunology and Childhood Cancer / Esma Ucisik-Akkaya and M. Tevfik Dorak -- Exposure to Environmental Mutagens: APC and Colorectal Carcinogenesis / Aruna S. Jaiswal, Melissa L. Armas, Shahnjayla K. Connors, Harekrushna Panda and Satya Narayan -- Gene-Environmental Interactions and Susceptibility to Liver Cancer / John B. Colerangle -- Genetic Epidemiology of Mismatch Repair Deficiency in Ovarian Cancer / Tuya Pal, Jenny Permuth Wey and Thomas A. Sellers -- Part 3. Case Studies -- Betel Nut and Susceptibility to Cancer / Rajesh N. Sharan and Yashmin Choudhury -- Birth Weight and Cancer Associations / Nadia Barahmani and M. Fatih Okcu -- Iron Excess and Cancer / Charronne F. Davis and M. Tevfik Dorak.
  • Also available: Print – 2007
  • Environmental genomics 2007
    Springer Protocols
    Preface -- Contributors -- Pt. 1. Gene expression profiling -- 1. High-throughput whole mount in situ hybridization of zebrafish embryos for analysis of tissue-specific gene expression changes after environmental perturbation / Louise E. Coverdale, Lindsay E. Burton, and C. Cristofre Martin -- 2. Fluorescent RNA arbitrarily primed polymerase chain reaction / Doug Crump ... [et al.] -- 3. Isolation of O₃-response genes from Arabidopsis thaliana using cDNA macroarray / Masanori Tamaoki -- 4. Use of cDNA macroarrays and gene profiling for detection of effects of environmental toxicants / Jason L. Blum ... [et al.] -- 5. Constructing and screening a cDNA library / Kevin Larade and Kenneth B. Storey -- 6. Comparative molecular physiological genomics / Sean F. Eddy and Kenneth B. Storey -- 7. Proteomic analysis of neuroendocrine peptidergic system disruption using the AtT20 pituitary cell line as a model / Fumin Dong ... [et al.] -- 8. Proteomics-based method for risk assessment of peroxisome proliferating pollutants in the marine environment / Susana Cristobal -- 9. Environmental metabolomics using ¹H-NMR spectroscopy / Mark R. Viant -- Pt. 2. Detection of whole genome mutation -- 10. Restriction landmark genome scanning for the detection of mutations / Jun-ichi Asakawa -- 11. Use of the comet assay in environmental toxicology / Loren D. Knopper and James P. McNamee -- 12. The micronucleus assay determination of chromosomal level DNA damage / Michael Fenech -- 13. Fluorescence in situ hybridization for the detection of chromosome aberrations and aneuploidy induced by environmental toxicants / Francesca Pacchierotti and Antonella Sgura -- 14. Laboratory methods for the detection of chromosomal structural aberrations in human and mouse sperm by fluorescence in situ hybridization / Francesco Marchetti, Debby Cabreros, and Andrew J. Wyrobek -- Pt. 3. Determination of species diversity -- 15. Assembling DNA barcodes / Jeremy R. deWaard ... [et al.] -- 16. Application of suppressive subtractive hybridization to uncover the metagenomic diversity of environmental samples / Elizabeth A. Galbraith, Dionysios A. Antonopoulos, and Bryan A. White -- 17. 16S rRNA targeted DGGE fingerprinting of microbial communities / Vesela A. Tzeneva ... [et al.] -- 18. An emulsion polymerase chain reaction-based method for molecular haplotyping / James G. Wetmur and Jia Chen -- Index.
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  • Globalization and sustainable growth -- Bioethics, environmental pollution and poverty -- Organizational performance and sustainability -- Environmental management and human progress -- Renewable energy. Ecosystems and environmental health -- Materials recycling and water treatment.
  • Environmental microbiology 2005
    Also available: Print – 2005
    Cultivation -- Physiological ecology -- Nucleic acid techniques.
  • 1. Free Radical Reactions in Human Disease / Barry Halliwell -- 2. Radicals and Inflammation: Mediators and Modulators / Claire A. Davies, David R. Blake, and Paul G. Winyard -- 3. Autoimmunity Caused by Oxidizing Foreign Compounds / Kaye H. Kilbur -- 4. Role of Oxidative Stress in Chemical Carcinogenesis / James E. Klaunig and Lisa M. Kamendulis -- 5. Proposed Mechanisms of Arsenic Toxicity Carcinogenesis / Michael I. Luster and Petia P. Simeonova -- 6. Redox Regulation of Gene Expression and Transcription Factors in Response to Environmental Oxidants / Hiroshi Masutani, Akira Nishiyama, Yong-Won Kwon, Yong-Chul Kim, Hajime Nakamura, and Junji Yodoi -- II. Target Organs of Environmental Oxidants: Lung -- 7. Cigarette Smoking and Pulmonary Oxidative Damage / Ching K. Chow -- 8. Health Effects of Diesel Exhaust and Diesel Exhaust Particles / Masaru Sagai and Takamichi Ichinose -- 9. The Role of Free Radicals in Asbestos- and Silica-Induced Fibrotic Lung Diseases / Arti Shukla, Cynthia R. Timblin, Brooke T. Mossman, and Andrea Hubbard -- 10. Reactive Oxygen Species and Silica-Induced Carcinogenesis / Xianglin Shi, Min Ding, Fei Chen, Val Vallyathan, and Vince Castranova -- 11. Atmospheric Oxidants and Respiratory Tract Surfaces / Carroll E. Cross, Samuel Louie, Sunye Kwack, Pat Wong, Sharanya Reddy, and Albert van der Vliet -- III. Target Organs of Environmental Oxidants: Skin -- 12. Redox Modulation and Oxidative Stress in Dermatotoxicology / Jiirgen Fuchs, Maurizio Podda, and Thomas Zollner -- 13. Dermatotoxicology of Environmental and Occupational Chemical Hazards: Agents and Action / Jiirgen Fuchs -- 14. Photooxidative Stress in Skin and Regulation of Gene Expression / Lee Ann Laurent-Applegate and Stefan Schwarzkopf -- 15. Ozone Stress in the Skin Barrier / Stefan U. Weber and Lester Packer -- 16. Immunotoxicity of Environmental Agents in the Skin / Santosh K. Katiyar and Hasan Mukhtar -- IV. Target Organs of Environmental Oxidants: Eye -- 17. Environmental Stressors and the Eye / John R Trevithick and Kenneth P. Mitton -- 18. Free Radicals and Aging of Anterior Segment Tissues of the Eye / Keith Green -- 19. The Role of Ocular Free Radicals in Age-Related Macular Degeneration / Paul S. Bernstein and Nikita B. Katz -- 20. Nutritional Influences on Risk for Cataract / Allen Taylor.
  • Environmental toxicology 2005
    The utility of zebrafish as a model for toxicological research / Michael J. Carvan III, Tisha King Heiden and Henry Tomasiewicz -- Use of fish cell lines in the toxicology and ecotoxicology of fish : piscine cell lines in environmental toxicology / N.C. Bols, V.R. Dayeh, L.E.J. Lee and K. Schirmer -- Approaches in proteomics and genomics for eco-toxicology -- Nancy D. Denslow, Iris Knoebl and Patrick Larkin -- Interactions between lipids and persistent organic pollutants in fish / Adria A. Elskus, Tracy K. Collier and Emily Monosson -- Metabolic fate of nonylphenols and related phenolic compounds in fish / Jean-Pierre Cravedi and Daniel Zalko -- Pesticide biotransformation in fish / Daniel Schlenk -- Xenobiotic receptors in fish : Structural and functional diversity and evolutionary insights / Mark E. Hahn, Rebeka R. Merson and Sibel I. Karchner -- Impacts of environmental toxicants and natural variables on the immune system of fishes / Karen G. Burnett -- Fish models of carcinogenesis / Gary K. Ostrander and Jeanette M. Rotchell -- Metallothionein : structure and regulation / Peter Kling and Per-Erik Olsson -- Cell death : investigation and application in fish toxicology / Antony W. Wood, David M. Janz and Glen J. Van Der Kraak -- Adrenal toxicology : environmental pollutants and the HPI axis / Alice Hontela -- Xenobiotic impact on corticosteroid signaling / Mathilakath M. Vijayan, Patrick Prunet and Adrienne N. Boone -- Thyroid hormones / J.G. Eales and S.B. Brown -- The biology and toxicology of retinoids in fish / D. Alsop, Glen J. Van Der Kraak, S.B. Brown and J.G. Eales -- Vitellogenesis and endocrine disruption / Naoshi Hiramatsu, Ann O. Cheek, Craig V. Sullivan, Takahiro Matsubara and Akihiko Hara -- Pharmaceuticals in the environment : drugged fish? / Vance L. Trudeau, Chris D. Metcalfe, Caroline Mimeault and Thomas W. Moon -- P-glycoproteins and xenobiotic efflux transport in fish / Armin Sturm and Helmut Segner.
  • "Satellite imagery and data are widely used in public health surveillance to provide early warning of disease outbreaks and for averting pandemics. Convergence of these technologies began in the 1970s and has gained wide acceptance in the 21st Century. This book is written jointly by experts in both the health and Earth-science technologies. Each chapter is accompanied by an extensive list of citations to provide background and validation of the current state-of-the-art for a variety of high-interest human diseases and associated health and well-being issues. The importance of day-to-day weather patterns, the impacts of severe weather events and longer-term climate cycles form the basis for developing information systems that meet goals and expectations of national and international health monitoring bodies"--Provided by publisher.
  • Common diseases arise out of combination of both genetic and environmental influences. Advances in genomic technology have enabled investigators to create hypotheses regarding the contribution of genetic factors at a breathtaking pace. However, the assessment of multiple and specific environmental factors--and their interactions with the genome-- has not. We lack high-throughput analytic methodologies to comprehensively and systematically associate multiple physical and specific environmental factors, or the "envirome", to disease and human health. We claim that the creation of hypotheses regarding the environmental contribution to disease is practicable through high-throughput analytic methods that have been well established in genomics. In the following dissertation, we develop and apply methods to systematically and comprehensively associate specific factors of the envirome with disease states, prioritizing factors for in-depth future study. The current disciplines of studying the environmental determinants of health include toxicology and epidemiology, which operate on molecular and population scales, respectively. This dissertation proposes approaches in both of these disciplines. For example, we have developed a framework to conduct the first "Environment-wide Association Study" (EWAS), systematically associating environmental factors to disease on a population scale. We have applied this framework to investigate type 2 diabetes and heart disease on cohorts that are representative United States population, finding novel and robust associations in diverse and independent cohorts. Given the lack of explained risk resulting from current day genome-wide studies, the time is ripe to usher in a more comprehensive study of the environment, or "enviromics", toward better understanding of multifactorial diseases and their prevention.
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  • Also available: Print – 2014
    Enzinger and Weiss's Soft Tissue Tumors is a medical reference on the diagnosis of tumors of the skeletal muscles, connective tissue, fat, and related structures. Microscopic findings are correlated with the latest developments in molecular biology, cytogenetics, and immunohistochemistry, providing you with a comprehensive and integrated approach to the evaluation of soft tissue specimens. Apply the latest advances in surgical pathology thanks to major updates on recently identified pathological entities such as soft tissue angiofibroma and CIC-related sarcomas; coverage of the newest molecular diagnostic techniques and immunohistochemical and molecular genetic features of soft tissue tumors; new chapters on GIST and soft tissue tumors showing melanocytic differentiation; and more. Effortlessly find the information you need with a chapter organization based on the newest surgical pathology concepts and classifications of soft tissue tumors.
  • Transformations using enzymes have been extensively investigated in the last two decades and the results promise great potential for this growing field, especially in the area of synthetic organic chemistry mainly due to of its many advantages. Accordingly, this book has attempted to bring out the advantages of using enzymes involving complex underivatized and unprotected substrates in non-polar media under homogenous and heterogeneous reaction conditions. Merits and demerits of using enzymes in terms of yields and selectivity/specificity are presented without any prejudice. Almost all the reactions dealt with are from the author's laboratory comprising diverse substrates, and the catalysis involves two important hydrolyzing enzymes, extensively examined for the reverse reactions. Thus, esterification involving lipses and glycosylation involving glycosidases were investigated with respect to various strategies like optimization of reaction conditions, response surface methodology and kinetics, carrying out reactions under solvent, non-solvent and super critical carbon dioxide conditions. In short, the work presented is to ensure the comprehension of the problems faced by the researchers in this area so as to work out further efficient strategies for carrying out enzymatic transformations in the laboratory successfully with better yields and specificity.
  • Chapter 1. An Introduction to Enzyme Science -- Chapter 2. Active Sites and their Chemical Properties -- Chapter 3. Fundamentals of Chemical Kinetics -- Chapter 4. Practical Aspects of Measuring Initial Rates and Reaction Parameters -- Chapter 5. Initial-Rate Kinetics of One-Substrate Enzyme-Catalyzed Reactions -- Chapter 6. Initial-Rate Kinetics of Multi-Substrate Enzyme-Catalyzed Reactions -- Chapter 7. Factors Influencing Enzyme Activity -- Chapter 8. Kinetic Behavior of Enzyme Inhibitors -- Chapter 9. Isotopic Probes of Biological Catalysis -- Chapter 10. Probing Fast Enzyme Processes -- Chapter 11. Regulatory Behavior of Enzymes -- Chapter 12. Single-Molecule Enzyme Kinetics -- Chapter 13. Mechanoenzymes: Catalysis, Force Generation and Kinetics.
  • Introduction, p. 1-3 -- ch. 1. Multiple Equilibria, p. 5-50 -- ch. 2. Enzyme Kinetics, p. 51-160 -- ch. 3. Methods, p. 161-246.
  • Also available: Print – v. 53, 2011.
  • Also available: Print – 1982
  • Also available: Print – 1995
  • Also available: Print – 2002
  • Also available: Print – 1984
  • Introduction to the field of enzyme immobilization and stabilization -- Stabilization of enzymes through encapsulation in liposomes -- Micellar enzymology for thermal, pH, and solvent stability -- Lipase activation and stabilization in room-temperature ionic liquids -- Nanoporous silica glass for the immobilization of interactive enzyme systems -- Enzyme stabilization and immobilization by sol-gel entrapment -- Nanoporous gold for enzyme immobilization -- Enzyme stabilization via bio-templated silicification reactions -- The immobilization of enzyme on Eupergit) supports by covalent attachment -- Micellar polymer encapsulation of enzymes -- Enzyme stabilization via cross-linked enzyme aggregates -- Enzyme immobilization in polyelectrolyte microcapsules -- Macroporous poly(GMA-co-EGDMA) for enzyme stabilization -- Enzyme-nanoparticle conjugates for biomedical applications -- Enzyme nanoparticle fabrication: Magnetic nanoparticle synthesis and enzyme immobilization -- Cytochrome C stabilization and immobilization in aerogels -- Kinetic measurements for enzyme immobilization.
  • Also available: Print – 1983
  • Also available: Print – 1985
  • Also available: Print – 1986
  • Also available: Print – 1986
  • 1. Enzyme Activities and Microbiological and Biochemical Processes in Soil / Paolo Nannipieri, Ellen Kandeler, and Pacifico Ruggiero -- 2. Ecology of Microbial Enzymes in Lake Ecosystems / Ryszard Jan Chróst and Waldemar Siuda -- 3. Ecological Significance of Bacterial Enzymes in the Marine Environment / Hans-Georg Hoppe, Carol Arosti, and Gerhard F. Herndl -- 4. Enzymes and Microorganisms in the Rhizosphere / David C. Naseby and James M. Lynch -- 5. Enzymes in the Arbuscular Mycorrhizal Symbiosis / José Manuel García-Garrido, Juan Antonio Ocampo, and Inmaculada García-Romera -- 6. Microbes and Enzymes Associated with Plant Surfaces / Alan P. Thompson and Mark J. Bailey -- 7. Microbial Enzymes in the Biocontrol of Plant Pathogens and Pests / Leonid Cherin and Ilan Chet -- 8. Microbiology and Enzymology of Carbon and Nitrogen Cycling / Robert L. Tate III -- 9. Enzyme and Microbial Dynamics of Litter Decomposition / Robert L. Sinsabaugh, Margaret M. Carreiro, and Sergio Alvarez -- 10. Fungal Communities, Succession, Enzymes, and Decomposition / Annelise H. Kjøller and Sten Struwe -- 11. Enzyme Adsorption on Soil Mineral Surfaces and Consequences for the Catalytic Activity / Hervé Quiquampoix, Sylvie Servagent-Noinville, and Marie-Hélène Baron -- 12. Microbes and Enzymes in Biofilms / Jana Jass, Sara K. Roberts, and Hilary M. Lappin-Scott -- 13. Search for and Discovery of Microbial Enzymes from Thermally Extreme Environments in the Ocean / Jody W. Deming and John A. Baross -- 14. Molecular Methods for Assessing and Manipulating the Diversity of Microbial Populations and Processes / Søren J. Sørensen, Julia R. de Lipthay, Anne Kirstine Müller, Tamar Barkay, Lars H. Hansen, and Lasse Dam Rasmussen -- 15. Bioindicators and Sensors of Soil Health and the Application of Geostatistics / Ken Killham and William J. Staddon -- 16. Hydrolytic Enzyme Activities to Assess Soil Degradation and Recovery / Tom W. Speir and Des J. Ross -- 17. Enzymatic Responses to Pollution in Sediments and Aquatic Systems / Sabine Kuhbier, Hans-Joachim Lorch, and Johannes C.G. Ottow -- 18. Microbial Dehalogenation Reactions in Microorganisms / Lee A. Beaudette, William J. Staddon, Michael B. Cassidy, Marc Habash, Hung Lee, and Jack T. Trevors -- 19. Isolated Enzymes for the Transformation and Det6xification of Organic Pollutants / Liliana Gianfreda and Jean-Marc Bollag -- 20. Enzyme-Mediated Transformations of Heavy Metals/Metalloids: Applications in Bioremediation / Robert S. Dungan and William T. Frankenberger, Jr. -- 21. Enzymes in Soil: Research and Developments in Measuring Activities / M. Ali Tabatabai and Warren A. Dick.
  • "'Do no harm' a particularly leading and important phrase in the delivery of healthcare is not working. In fact depending on the epidemiological approach and which data sets one applies, medical errors, hospital acquired infections (HAIs) and pharmaceutical errors combined are the second or third leading killer of Americans annually: approximately 300,000 die from a combination of medical errors, hospital acquired infections (HAIs), and pharmaceutical errors...100,000 per category. Add to these numbers the hundreds of thousands who are harmed (morbidity) but not killed (mortality) changing quality of life and a substantial problem is defined"--Provided by publisher.
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    Preface -- Epidemic in Athens, 430-427 B.C.E. -- Malaria in ancient Rome -- Plague of the Antonines -- First plague pandemic, 541-747 -- Smallpox epidemic in Japan, 735-737 -- Leprosy in medieval Europe -- Second plague pandemic, 1346-1844 -- "French disease" in sixteenth-century Europe -- Epidemics in sixteenth-century America -- Epidemics and the Thirty Years' War, 1618-1648 -- Plague in Italian cities, 1630s -- Epidemics in China, 1640-1644 -- Plague in London, 1665 -- Smallpox in Iceland, 1707-1709 -- Plague in Marseilles, 1720-1722 -- Smallpox in Boston, 1721 -- Smallpox in eighteenth-century Europe -- Plague in Moscow, 1771 -- Influenza pandemic, 1781-1782 -- Yellow fever in Hispaniola, 1793-1804 -- Yellow fever in Philadelphia, 1793 -- First cholera pandemic, 1817-1824 -- Consumption in the nineteenth century -- Second cholera pandemic, 1827-1835 -- Third cholera pandemic, 1839-1856 -- "Fevers" and the great famine in Ireland, 1846-1850 -- Typhoid fever in cities, 1850-1920 -- Yellow fever in New Orleans, 1853 -- Fourth cholera pandemic, 1863-1875 -- Carrion's disease in Peru, 1870-1871 -- Smallpox in Europe, 1870-1875 -- Measles in Fiji, 1875 -- Fifth cholera pandemic, 1881-1896 -- Influenza pandemic, 1889-1890 -- Cholera epidemic in Hamburg, 1892 -- Third plague pandemic, 1894-? -- Sixth cholera pandemic, 1899-1923 -- Sleeping sickness in east central Africa, 1900-1905 -- Typhoid Mary's "epidemics" -- Cholera epidemic in Naples, 1910-1911 -- Poliomyelitis in the United States, 1916 -- Influenza pandemic, 1918-1919 -- Lung cancer in the United States, mid-twentieth century -- Poliomyelitis in the United States, 1945-1955 -- Seventh cholera pandemic, 1961-present -- Aids in the United States, 1980s -- Contemporary aids pandemic -- The mad cow crisis and transmissible spongiform encephalopathies, 1985-present -- Contemporary malaria -- Contemporary tuberculosis -- Epilogue -- Glossary.
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    The plague era - Modernity: new concepts of the state and the body -- Cholera: the return of epidemic disease and the abandonment of traditional protective measures -- The "English System:" new methods gain acceptance -- The sanitary reform movement: from miasma theory to departments of health -- Vaccination: a powerful paradigm -- The era of spectacular victories -- The end of a dream?
  • Asiatic cholera: mole hills and mountains -- Endemic and epidemic cholera in Africa -- Phenotypic and molecular characteristics of epidemic and non-epidemic vibrio cholerae strains isolated in Russia and certain countries of Commonwealth of Independent States (CIS) -- The re-emergence of cholera in the Americas -- The evolution of vibrio cholerae as a pathogen -- Molecular epidemiology of toxigenic vibrio cholerae -- Diversity and genetic basis of polysaccharide biosynthesis in vibrio cholerae -- Significance of the SXT/R391 family of integrating conjugative elements in vibrio cholerae -- Small molecule signaling systems in vibrio cholerae -- Vibrio cholerae flagellar synthesis and virulence -- Filamentous phages of vibrio cholerae O1 and O139 -- Pathogenic potential of non-O1, non-O139 vibrio cholerae -- Proteases produced by vibrio cholerae and other pathogenic vibrios: pathogenic roles and expression -- Toxins of vibrio cholerae and their role in inflammation, pathogenesis, and immunomodulation -- Vibrio cholerae hemolysin: an enigmatic pore-forming toxin -- Integrin-mediated antimicrobial resistance in vibrio cholerae -- Aquatic realm and cholera -- Management of cholera.
  • 1. Early Concepts of Communicability -- 2. Infection on the Move -- 3. The Impact of Cholera -- 4. Stiffening the Sinews -- 5. Dawn and Sunset -- 6. A Need for Damage Limitation -- 7. No Lasting Stability -- 8. Tailpiece.
  • Medicine, science, and statistics -- Terms and concepts in medicine -- Epidemiological research proper -- Introductory terms and concepts -- Terms and concepts of objects of study -- Terms and concepts of methods of study -- Meta-epidemiological clinical research -- Introductory terms and concepts -- Terms and concepts of objects of study -- Terms and concepts of methods of study.
  • Epidemiology: Grappling with the Concept -- Epidemiological Knowledge: Examples -- Etiology as a Pragmatic Concern -- Etiology as the Object of Study -- Etiologic Studies' Essentials -- Etiologic Studies' Typology -- Etiologic Studies' Objects Design -- Etiologic Studies' Methods Design -- Etiologic Studies' Intervention Counterparts -- Causal Studies' Acausal Counterparts -- Studies on Screening for a Cancer -- Some Paradigmatic Studies -- From Studies to Knowledge -- Fact-finding in Epidemiological Practice.
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    Basic study designs in analytical epidemiology -- Measuring disease occurence -- Measuring associations between exposures and outcomes -- Understanding lack of validity: bias -- Identifying noncausal associations: confounding -- Defining and assessing heterogeneity of effects: interaction -- Stratification and adjustment: multivariate analysis in epidemiology -- Quality assurance and control -- Communicating results of epidemiologic studies -- Epidemiologic issues in the interface with public health policy.
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  • Epidemiology, by award-winning educator and epidemiologist Leon Gordis, is a best-selling introduction to this complex science. Dr. Gordis leverages his vast experience teaching this subject in the classroom to introduce the basic principles and concepts of epidemiology in a clear, uniquely memorable way. He guides you from an explanation of the epidemiologic approach to disease and intervention, through the use of epidemiologic principles to identify the causes of disease, to a discussion of how epidemiology should be used to improve evaluation and public policy. It's your best choice for an accessible yet rich understanding of epidemiology! Gain a solid foundation of basic epidemiologic principles as well as practical applications in public health and clinical practice.Visualize concepts vividly through abundant full-color figures, graphs, and charts.Check your understanding of essential information with 320 multiple-choice epidemiology self-assessment questions (120 inside the book plus 200 more online).Access the complete contents online at Student Consult, including over 200 additional multiple-choice epidemiology self-assessment questions not found in the book, with answers to all questions as well as full rationales explaining why every answer is correct or incorrect.
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  • The average age of the world's population is increasing at an unprecedented rate and this increase is changing the world. This 'silver tsunami' emphasizes the need to provide advanced training in epidemiology and increase the cadre of experts in the study of aging. This book is designed to summarize unique methodological issues relevant to the study of aging, biomarkers of aging and the biology/physiology of aging and in-depth discussions of the etiology and epidemiology of common geriatric syndromes and diseases. Contributing authors in the book represent many disciplines, not only epidemiology and clinical geriatrics, but also demography, health services, research, cardiovascular disease, diabetes, psychiatry, neurology, social services, musculoskeletal diseases and cancer. The aim of the book is to provide a broad multidisciplinary background for any student/researcher interested in aging. The material in the book is organized and comprehensive. It represents the most up-to-date information on the scientific issues in aging research written by academics who specialize in research and training in the broad field of aging.The structure and organization of the book reflects our course series in the Epidemiology of Aging starting with the broad issues of demography and methodology, and then addressing specific health conditions and geriatric conditions common to older persons.
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  • Defining and measuring drug abusing behaviors / Zili Sloboda -- Drug abuse heterogeneity and the search for subtypes / Meyer D. Glantz, Devin P. Conway and James D. Colliver -- Studying the natural history of drug use / Yih-Ing Hser ... [et al.] -- Health, social and psychological consequences of drug use and abuse / Michael D. Newcomb and Thomas Locke -- Use of archival data / Zili Sloboda, Rebecca McKetin and Nicholas J. Kozel -- Sampling issues in drug epidemiology / Colin Taylor and Paul Griffiths -- Collecting drug use data from different populations / Edward M. Adlaf -- Indirect methods to estimate prevalence / Matthew Hickman and Colin Taylor -- Qualitative methods in the drug abuse field / Claire E. Sterk and Kirk W. Elifson -- Ethical considerations for drug abuse epidemiologic research / Craig L. Fry and Wayne Hall -- A common language for a common problems: the developing role of drug epidemiology in a global context / Paul Griffiths and Rebecca McKetin -- Longitudinal studies of drug use and abuse / Thomas A. Wills, Carmella Walker and Jody A. Resko -- Drug abuse and the spread of infection: HIV and AIDS as an example / Don C. Des Jarlais, Holly Hagan and Samuel R. Friedman -- Implications of epidemiologic information for effective drug abuse prevention strategies / Zili Sloboda -- The role of treatment data in studying the epidemiology of substance use and abuse / Robert L. Hubbard.
  • Authored by Bengt Kallen, professor emeritus in embryology at Lund University in Sweden. The subject of this book is to describe the occurrence of congenital malformations among children born and what risk factors exist. Population data are presented for a number of malformations, ascertained with the use of data from the Swedish national health registers for the period 1998-2010 corresponding to some 1.3 million births, together with prospectively collected information on a group of exposures of possible interest.
  • The epidemiology of injury in adventure and extreme sports / Dennis J. Caine -- The epidemiology of injury in mountaineering, rock and ice climbing / Volker Schöffl ... [et al.] -- The epidemiology of injury in hang-gliding and paragliding / Tiina Rekand -- The epidemiology of injury in scuba diving / Peter L. Buzzacott -- The epidemiology of injury among surfers, kite surfers and personal watercraft riders : wind and waves / Terri J. Pikora, Rebecca Braham, Christina Mills -- The epidemiology of injury in canoeing, kayaking and rafting / Richard C. Franklin, Peter A. Leggat -- The epidemiology of injury in bungee jumping, BASE jumping, and skydiving / Kjetil Søreide -- The epidemiology of extreme hiking injuries in volcanic environments / Travis W. Heggie, Tracey M. Heggie -- The epidemiology of injury in skateboarding / Jamie Hunter -- The epidemiology of injury in ATV and motocross sports / A. Noelle Larson, Amy L. McIntosh.
  • v.2, 2005 Karger
    pt. 1. Individual sports -- pt. 2. Team sports.
  • Also available: Print – v. 1, 1873.
    pt. I. -- 1. The Doctrine of contagion -- 2. Modern theories, analysis of -- 3. The Propagation of cholera -- 4. Epizootics, or, Disease in the brute creation -- pt. II. Will shortly be issued, and will embrance the following subjects -- 5. The Remote cause of epidemic diseases in the animal creation -- 6. The Cause of blight and pestilence in the vegetable creation -- 7. The Cause of hurricanes, and abnormal atmospherical vicissitudes -- 8. Historical pathology, or a Brief history of the pestilences, murrains and blights, with the aberrations in the material world that have been observed during historical periods.
  • Benign melanocytic proliferations -- Essential criteria for diagnosing melanoma -- Histologic mimics of malignant melanoma -- Epidermal neoplasms -- Pilosebaceous neoplasms -- Tumors with eccrine differentiation -- Merkel cell carcinoma.
  • A historical perspective of EGF receptor and related systems / Francis Edwin ... [et al.] -- Purification and assay of kinase-active EGF receptor from mammalian cells by immunoaffinity chromatography / Gregory J. Wiepz ... [et al.] -- Soluble epidermal growth factor receptor acrydinium-linked immunosorbent assay / Jacqueline M. Lafky, Andre T. Baron, and Nita J. Maihle -- Analysis of epidermal growth factor receptor and interactions with the [alpha] subunit of the stimulatory GTP binding protein of adenylyl cyclase, Gs / Deepti Chaturvedi ... [et al.] -- Regulator of epidermal growth factor signaling : sprouty / Esther Sook Miin Wong and Graeme R. Guy -- Dissecting the epidermal growth factor signal transactivation pathway / Oliver M. Fischer, Stefan Hart, and Axel Ullrich -- A sensitive method to monitor ectodomain shedding of ligands of the epidermal growth factor receptor / Umut Sahin ... [et al.] -- In vitro and in vivo assays of monoubiquitnation of receptor tyrosine kinases / Manachem Katz, Yaron Mosesson, and Yosef Yarden -- Assays to monitor degradation of the EGF receptor / Mirko H.H. Schmidt and Ivan Dikic -- Assessment of degradation and ubiquitination of CXCR4, a GPCR regulated by EGFR family members / Adriano Marchese -- Epithelial cell migration in response to epidermal growth factor / Reema Zeineldin and Laurie G. Hudson -- Motility signaled from EGF receptors and related systems / Alan Wells ... [et al.] -- Methods for determining the proliferation of cells in response to EGFR ligands / Gregory J. Wiepz ... [et al.] -- Clinical advancement of EGFR inhibitors in cancer therapy / Prakash Chinnaiyan and Paul M. Harari.
  • This book offers an in-depth examination of labor pain and analgesia with the aim of promoting natural childbirth without pain. All aspects of the subject are covered, including the latest techniques of delivering labor analgesia. Importantly, emphasis is placed on a holistic approach, detailed attention being paid to the humanization of childbirth and behavioral aspects in addition to evidence-based medicine. Potential future developments are also addressed, with discussion of opportunities that have yet to be realized. In order to ensure that the text is easily readable for trainees as well as established practitioners, chapters have been restricted to a manageable length and information is presented clearly and succinctly. Step-by-step tutorials and boxes highlighting practical points are used to clarify technical aspects. The authors include both well-established experts and young emerging professionals from various European countries, ensuring an intercultural perspective.
  • Also available: Print – 2013
  • Introduction -- Immune System and Atopic Disorders -- Epigenetics -- Epigenetics, Environment, and Allergic Diseases -- Conclusions and Future Perspectives.
  • Epigenetics and chronic diseases : an overview / Rebecca Smith, Jonathan Mill -- Techniques to study DNA methylation and histone modification / Ester Lara ... [et al.] -- Mechanisms of epigenetic gene silencing / Marie-Pierre Lambert, Zdenko Herceg -- Mechanisms of epigenetic gene activation in disease : dynamics of DNA methylation and demethylation / Thierry Granbe, Edio Eligio Lourenco -- The role of histone demethylases in disease / Paul Cloos -- Autoimmune diseases / Travis Hughes, Amr H. Sawalha -- Epigenetics of rheumatoid arthritis / Aleksander M. Grabiec, Paul P. Tak, Kris A. Reedquist -- DNA methylation changes in osteoarthritis / Helmtrud I. Roach -- Epigenetics and Type 2 diabetes / Charlotte Ling, Tina Ronn, Marloes Dekker Nitert -- Epigenetic regulation of asthma and allergic diseases / Andrew L. Durham, Ivan M. Adcock -- Epigenetics in psychiatry / Hamid Mostafavi-Abdolmaleky, Stephen J. Glatt, Ming T. Tsuang -- Epigenetics and late-onset Alzheimer's disease / Axel Schumacher, Syed Bihaqi, Nasser H. Zawia -- Epigenetic mechanisms in the developmental origins of adult disease / Keith M. Godfrey ... [et al.] -- Targeting histone deacetylases in chronic obstructive pulmonary disease / Peter J. Barnes -- Clinical trials of epigenetic modifiers in the treatment of myelodysplastic syndrome / Lauren C. Suarez, Steven D. Gore.
  • Also available: Print – 2011
    An introduction to epigenetics / Esteban Ballestar -- Chromatin mechanisms regulating gene expression in health and disease / Constanze Bonifer and Peter N. Cockerill -- Epigenetic control of lymphocyte differentiation / Eduardo Lopez-Granados -- Epigenetic control in immune function / Peter J. van den Elsen, Marja C.J.A. van Eggermond, and Rutger J. Wierda -- DNA methylation and B-cell autoreactivity / Soizic Garaud, Pierre Youinou, and Yves Renaudineau -- Environmental agents and autoimmune diseases / Frederick W. Miller -- Epigenetic dysregulation of Epstein-Barr virus latency and development of autoimmune disease / Hans Helmut Niller ... [et al.] -- Does genomic imprinting play a role in autoimmunity? / Cristina Camprubø and David Monk -- A new epigenetic challenge : systemic lupus erythematosus / Biola M. Javierre and Bruce C. Richardson -- Epigenetic deregulation in rheumatoid arthritis / Emmanuel Karouzakis ... [et al.] -- Prospects for epigenetic compounds in the treatment of autoimmune disease / Nadine Chapman-Rothe and Robert Brown -- Profiling epigenetic alterations in disease / Josø Ignacio Martøn-Subero and Manel Esteller.
  • Human epigenome -- Considerations in the design, conduct, and interpretation of studies in epigenetic epidemiology -- Laboratory methods in epigenetic epidemiology -- Biostatistical methods in epigenetic epidemiology -- Epigenome changes during development -- Role of epigenetics in the development origins of health and disease -- Epigenetics and assisted reproductive technology -- Imprinting disorders of early childhood -- Utility of twins for epigenetic analysis -- Age-related variation in DNA methylation -- Influence of environmental factors on the epigenome -- Epigenetic epidemiology of cancer -- Epigenetic epidemiology of infectious diseases -- Epigenetic epidemiology of inflammation and rhematoid arthritis -- Asthma epigenetics : emergnece of a new paradigm? -- Epigenetic epidemiology of autism and other neurodevelopmental disorders -- Epigenetic epidemiology psychiatric disorders -- Epigenetic epidemiology of type 1 diabetes -- Epigenetic epidemiology of obesity, type 2 diabetes -- Epigenetic epidemiology of atherosclerosis.
  • Behavioral Epigenetics is the study of how environmental factors affect alterations in behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcome. With an understanding of the molecular mechanisms involved in epigenetic modulation, researchers believe it will be possible to develop targeted therapies for those individuals in whom it malfunctions. This volume will address current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior.
  • The ability of an animal to change quickly in response to its surroundings is essential to its survival and in some species, individuals respond by changing phenotype. The studies in this thesis focus on the molecular mechanisms through which environmental information can affect changes in phenotype in an African cichlid fish, Astatotilapia burtoni. This species is particularly useful for this study, as adult male burtoni assume one of two distinct, reversible, behavioral and physiological phenotypes. Dominant (D) males are brightly colored, reproductively capable and engage in mating and aggressive territorial behaviors while non-dominant (ND) males are drably colored, reproductively incapable, and are behaviorally passive. Importantly, the transition from ND to D or the reverse can occur in a matter of minutes and is triggered solely by external social cues. How such external information is translated into phenotypic changes on the molecular level is the focus of these experiments and my data suggest an epigenetic mechanism may regulate this transition. The specific epigenetic mechanism assessed here is DNA methylation, which is the covalent attachment of a methyl group to the cytosine nucleotide of DNA, which can lead to changes in expression. First, I showed that DNA methylation is present in A. burtoni, as not all animals utilize this mechanism. I used immunohistochemistry to demonstrate that high levels of global methylation are present in the nuclei of all cells examined, most likely bound with the highest frequency to heterochromatin, to suppress transcription of specific transcribed regions. However, there were no differences detected between behavioral states using these methods. Next I demonstrated that epigenetic mechanisms play a role during the determination of social status by treating juvenile males with epigenetic modifiers that either promote or interfere with DNA methyltransferase (DNMT). Animals injected with zebularine, which blocks the activity of DNMT, were statistically unlikely to ascend to D status, while those injected with methionine, which acts as a methyl donor, were statistically likely to become D males. Once a potential role for DNA methylation in social status determination was found, I surveyed potential sites of action on the GnRH1 gene, a key regulator of reproductive behavior, for variations in methylation on the single nucleotide level. I found that fully established Ds and NDs do not have differences in methylation levels in any on the individual nucleotides assayed on the GnRH1 promoter or coding region; however, juvenile males have lower levels of methylation than Ds at some sites on the promoter, while males transitioning to D status have lower average promoter methylation, but higher average coding region methylation than D males. Furthermore, ND animals injected with zebularine have higher average levels of methylation on both the promoter and coding region than control ND males. In order to better understand the context of the methylation changes during sexual maturation, methylation levels on the GnRH1 gene were measured during normal development. GnRH1 methylation levels remain constant between two and four weeks of age but increase significantly at several sites between 4 and 6 weeks of age. Furthermore, crowding mothers during the brooding stage and raising young in crowded tanks results in lower methylation levels at both 2 and 6 weeks of age, as well as causing delayed growth at the 6 week stage. Finally, I measured GnRH1 methylation in a non-reproductive context. Since GnRH agonists can interfere with short-term memory in humans, I measured changes in methylation in the GnRH1 gene during memory formation and storage. Animals who successfully learned a memory task showed a correlation with higher methylation at sites in the GnRH1 coding region than non-learners. Learners were successfully able to recall their training after three months; however, the increased methylation in the coding region was no longer present. In summary, DNA methylation is present in A. burtoni and increases on the GnRH1 gene promoter and coding sequence during transitions in development and sexual maturation. As GnRH1 expression levels are known to increase in these cases, increased methylation is not acting canonically as a repressor of expression on GnRH1. During short-term learning, higher methylation is limited to only the coding region of GnRH1, indicating that there may be several different epigenetic regulatory pathways involving this gene. Furthermore, the observation that there are no differences in GnRH1 methylation between stable D and ND males, or, in the long-term, between learners and non-learners, suggests that methylation in this location may be transitory and used as a short-term marker for other regulatory mechanisms.
  • Previous observations, generated by many in the field, have provided a first glimpse into the epigenetic mechanisms that underpin lymphocyte and myeloid development. We are only now beginning to merge the multitude of observations into a common framework. At the same time it has become more difficult for the individual mind to comprehend more than a tiny focused fraction of it. The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression.
  • In both mammals and insects an olfactory neuron will usually select a single olfactory receptor and repress remaining members of large receptor families. Here we show that a conserved multiprotein complex Myb-MuvB(MMB)/dREAM plays an important role in mediating neuron-specific expression of the CO2 receptor genes (Gr63a/Gr21a) in Drosophila. Activity of Myb in the complex is required for expression of Gr63a/Gr21a and it acts in opposition to the histone methyltransferase Su(var)3-9. Consistent with this, we observe repressive di-methylated H3K9 modifications at the receptor gene loci suggesting a mechanism for silencing receptor gene expression. Conversely, other complex members, Mip120 and E2F2, are required for repression of Gr63a in inappropriate neurons. Misexpression in mutants is accompanied by an increase in the H3K4me3 mark of active chromatin at the receptor gene locus. Nuclei of CO2 receptor-expressing neurons contain reduced levels of the repressive subunit Mip120 compared to surrounding neurons and increased levels of Myb, suggesting that activity of the complex can be regulated in a cell-specific manner. Our evidence suggests a model in which olfactory receptors are regulated epigenetically and the MMB/dREAM complex plays a critical role in specifying, maintaining and modulating the receptor-to-neuron map.
  • Also available: Print – 2006
  • The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders such as myeloid leukemias and preleukemias (myelodysplasias) is now being translated into treatment approaches that target the epigenetic defects pharmacologically. Such approaches include reactivation of tumor suppressor genes and other antiproliferative genes by reversal of DNA hypermethylation through azanucleosides, and use of HDAC inhibitors to reverse gene silencing mediated by chimeric, leukemia-specific transcription factors. This book first presents the latest evidence derived from preclinical models regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the translation of basic research and drug development to clinical applications, and in this context both present and future clinical strategies are considered. Individual chapters are devoted to the use of DNA hypomethylating agents and chromatin-modifying agents, and the treatment of hematologic malignancies and solid tumors by means of epigenetic agents is discussed in detail.
  • Epigenetics is the phenomenon which fine tunes the processes associated with life, beyond that which is specified by the sequence of the genetic material; DNA. The covalent modification of DNA, DNA associated histones, several non histone proteins as well as non coding RNA coherently operate to establish the epigenetic regulation of gene expression in physiological and pathophysiological conditions. This volume presents contributions from worldwide experts presenting their research and findings, including: the evolution of epigenetic machineries from archaea to higher eukaryotes; role of epigenetics in development and transcription regulation; epigenetic landscape of human disease; a chemical biology approach to understanding epigenetic phenomena; exploration of different small molecules as epigenetic therapies.This volume is aimed at students and researchers of chromatin biology and epigenetics and will also be of interest to a broader pharmaceutical audience.
  • Systems and Network Biology to Investigate Epigenetic De-regulatory Mechanisms of MicroRNAs in Pancreatic Cancer / Irfana Muqbil, Fazlul H. Sarkar, Ramzi M. Mohammad -- Role of MicroRNAs in Cancer Epigenetics / Kishore B. Challagundla, Petra Wise, Muller Fabbri -- Epigenetic Regulation of EZH2 and Its Targeted MicroRNAs / Sandy Leung-Kuen Au, Irene Oi-Lin Ng, Chun-Ming Wong -- Epigenetics and MicroRNAs in Renal Cancer / Shahana Majid ... [et al.] -- Epigenetic Regulation of MicroRNA in Colon Cancer / Qiong Zhang, Mukesh Verma, Sharad Khare -- Epigenetic Regulation of miRNAs in Breast Cancer Formation and Progression / Zhiqian Zhang ... [et al.] -- Epigenetic Variations of Stem Cell Markers in Cancer / Sripathi M. Sureban, Dongfeng Qu, Courtney W. Houchen -- Recent Updates on Epigenetic Biomarkers for Prostate Cancer / Karen Chiam, Tanya Kate Day, Tina Bianco-Miotto -- Epigenetics and Racial Disparities in Prostate Cancer / Benjamin A. Rybicki -- Epigenetic Signatures of Breast Cancer Genes / Shrikant Anant, Animesh Dhar, Satish Ramalingam -- Exploiting Epigenetic Modifiers to Circumvent Melanoma Dual Resistance to TCR-Engineered Immunotherapy- and BRAF V⁶⁰⁰E-Kinase Inhibitor / Ali R. Jazirehi CLS, -- The Role of Epigenetics in Radiation Therapy and the DNA Damage Response / Steven P. Zielske -- Plant Polyphenols as Epigenetic Modulators of Glutathione S-Transferase P1 Activity / Vijay S. Thakur, Sanjay Gupta -- Epigenetic Regulations of mRNAs and miRNAs by Nutraceuticals / Yiwei Li ... [et al.] -- Towards Curative Cancer Therapy with Maspin: A Unique Window of Opportunity to Target Cancer Dormancy / Alexander Kaplun, M. Margarida Bernardo, Sijana Dzinic.
  • Chromatin remodeling factors and DNA replication -- Epigenetic inheritance of chromatin states mediated by polycomb and trithorax group proteins in drosophila -- How to pack the genome for a safe trip -- Chromatin modifications on the inactive x chromosome -- Chromatin mechanisms in drosophila dosage compensation -- DNA methylation in epigenetic control of gene expression -- The epigenetic breakdown of cancer cells: from DNA methylation to histone modifications -- Developmental regulation of the beta-globin gene locus -- Epigenetic regulation of mammalian imprinted genes: from primary to functional imprints -- Seed development and genomic imprinting in plants.
  • "Epigenetics and Complex Traits provides an overview of basic epigenetic phenomena that influence transmission of genetic traits, including the pivotal roles of epigenetic factors in genome integrity, genetic transmission and phenotypic variation at critical developmental points, interactions between epigenetic marks and genetic variation, as well as a detailed examination of how epigenetic considerations can alter interpretation and analysis of risks for complex traits. Included in this book are several overviews of the impact of inter-individual variation in epigenetic states, from major changes that cause congenital developmental defects to subtle changes and their impact on complex traits. In addition, there are chapters examining the relationship between epigenetic changes and genetic changes in human disease, methods for statistical analysis of epigenetics effects in human disease genetic studies or in population genetics, and a consideration of how epigenetics influences inheritance and analysis of inheritance. Epigenetics and Complex Traits is a resource for those who are working in mammalian genetics or analysis of human genetic data and are interested in the impact of epigenetics on inheritance."-- Back cover.
  • DNA Methylation and Cancer -- Genome-Wide Epigenetic Modifications in Cancer -- DNA Repair and the Control of DNA Methylation -- Errors in Erasure: Links Between Histone Lysine Methylation Removal and Disease -- Histone Modifications in Cancer Biology and Prognosis -- Dynamics of Histone Lysine Methylation: Structures of Methyl Writers and Erasers -- Epigenetic Mechanisms of Mental Retardation -- Histone and DNA Modifications in Mental Retardation -- HDAC Inhibitors and Cancer Therapy -- Epigenetic Mechanisms in Acute Myeloid Leukemia -- The Liver-Specific MicroRNA miR-122: Biology and Therapeutic Potential -- Transcriptional Regulatory Networks in Embryonic Stem Cells -- Small Molecules in Cellular Reprogramming and Differentiation -- Index.
  • pt. 1. Medical aspects and questions raised on the molecular basis of epigenome involvement in reproduction -- pt. 2. Fundamental aspects of genome and epigenome reprogramming during gametogenesis -- pt. 3. Re-organization of nuclear compartmetns during gametogenesis -- pt. 4. Fundamental aspects of gene expression regulation during gametogenesis.
  • 1. Epigenetics of host-pathogen interactions : the road ahead and the road behind / Elena Gm̤ez-Da̕z, Mireia Jord,̉ Miguel Angel Peinado, and Ana Rivero -- 2. A concise review on epigenetic regulation : insight into molecular mechanisms / Shahram Golbabapour, Mahmood Ameen Abdulla, and Maryam Hajrezaei -- 3. Genome-wide analysis of DNA methylation in human amnion / Jinsil Kim, Mitchell M. Pitlick, Paul J. Christine, Amanda R. Schaefer, Cesar Saleme, Belň Comas, Viviana Cosentino, Enrique Gadow, and Jeffrey C. Murray -- 4. Assessing causal relationships in genomics : from Bradford-Hill criteria to complex gene-environment interactions and directed acyclic graphs / Sara Geneletti, Valentina Gallo, Miquel Porta, Muin J. Khoury, and Paolo Vineis -- 5. The biology of lysine acetylation integrates transcriptional programming and metabolism / Jigneshkumar Patel, Ravi R. Pathak, and Shiraz Mujtaba -- 6. Roles of histone deacetylases in epigenetic regulation : emerging paradigms from studies with inhibitors / Geneviv̈e P. Delcuve, Dilshad H. Khan, and James R. Davie -- 7. Aberrant epigenetic silencing is triggered by a transient reduction in gene expression / Jon A. Oyer, Adrian Chu, Sukhmani Brar, and Mitchell S. Turker -- 8. The sound of silence : RNAi in poly (ADP-Ribose) research / Christian Blenn, Philippe Wyrsch, and Felix R. Althaus -- 9. Epigenetic deregulation of microRNAs in rhabdomyosarcoma and neuroblastoma and translational perspectives / Paolo Romania, Alice Bertaina, Giorgia Bracaglia, Franco Locatelli, Doriana Fruci, and Rossella Rota -- 10. Epigenetic effects of environmental chemicals bisphenol A and phthalates / Sher Singh and Steven Shoei-Lung Li -- 11. The influence of DNA sequence on epigenome-induced pathologies / Richard B. Meagher and Kristofer J. M¿ssar -- 12. Next generation sequencing based approaches to epigenomics / Martin Hirst and Marco A. Marra -- 13. Design and analysis issues in gene and environment studies / Chen-Yu Liu, Arnab Maity, Xihong Lin, Robert O. Wright, and David C. Christiani.
  • "What lies at the heart of neuronal plasticity? Accumulating evidence points to epigenetics. This word originally indicated potentially heritable modifications in gene expression that do not involve changes in DNA sequence. Today this definition is much less strict, and epigenetic control is thought to include DNA methylation, histone modifications, histone variants, microRNA metabolic pathways and non-histone proteins modifications. Thus, while neuronal plasticity is rightly thought to be intimately associated to genomic control, it is critical to appreciate that there is much more to the genome than DNA sequence. Recent years have seen spectacular advances in the field of epigenetics. These have attracted the interest of researchers in many fields and evidence connecting epigenetic regulation to brain functions has been accumulating. Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. A variety of studies have centered on the molecular mechanisms implicated in epigenetic control and how these may operate in concert. It will be critical to unravel how specificity is achieved. Importantly, specific modifications seem to mediate both developmental processes and adult brain functions, such as synaptic plasticity and memory. Many aspects of the research in neurosciences and endocrinology during the upcoming decade will be dominated by the deciphering of epigenetic control. This book constitutes a compendium of the most updated views in the field"--Publisher.
  • Epigenetics and cancer: DNA methylation / Santiago Ropero and Manel Esteller -- Epigenetics and cancer: histone modifications / Mario F. Fraga and Manel Esteller -- Epigenetic drugs: DNA demethylating agents / Ehab Atallah, Guillermo Garcia-Manero -- Epigenetic drugs: histone deacetylase inhibitors / Melissa Peart, Ricky W. Johnstone -- Sirtuins in biology and disease / Alejandro Vaquero, Danny Reinberg -- MicroRNAs in cell biology and disease / Muller Fabbri, Carlo M. Croce, George A. Calin -- Chromatin modifications by polycomb complexes / Miguel Vidal -- Epigenetics and its genetic syndromes / Richard J. Gibbons -- Epigenetics and immunity / Esteban Ballestar and Bruce C. Richardson -- Aetiology of major psychosis: why do we need epigenetics? / Gabriel Oh and Arturas Petronis -- Epigenetics and cardiovascular disease / Gertrund Lund and Silvio Zaina -- Epigenetics and plant biology / Luis Valledor ... [et al.] -- Epigenetics, environment, and evolution / Douglas M. Ruden, Parsa Rasouli, Xiangyi Lu -- Epigenetics and epigenomics / Jose Ignacio Martin-Subero, Reiner Siebert.
  • Epigenetics of human disease / Trygve O. Tollefsbol -- Methods and strategies to determine epigenetic variation in human disease / Yoshihisa Watanabe and Masato Maekawa -- DNA methylation alterations in human cancers / Yae Kanai and Eri Arai -- Alterations of histone modifications in cancer / Ciro Mercurio, Simon Plyte and Saverio Minucci -- MicroRNA in oncogenesis / Niamh Lynam-Lennon, Steven G. Gray and Stephen G. Maher -- Epigenetic approaches to cancer therapy / Sabita N. Saldanha and Trygve O. Tollefsbol -- Epigenomics in neurobehavioral diseases / Cassandra L. Smith and Kai Huang -- Emerging role of epigenetics in human neurodevelopmental disorders / K. Naga Mohan and J. Richard Chaillet -- The epigenetics of Alzheimer's disease / Fabio Coppedè -- Epigenetic modulation of human neurobiological disorders / Takeo Kubota ... [et al.] -- Epigenetic basis of autoimmune disorders in humans / Biola M. Javierre, Lorenza de la Rica and Esteban Ballestar -- Approaches to autoimmune disease using epigenetic therapy / Christopher Chang -- Epigenetic mechanisms of human imprinting disorders / Richard H. Scott and Gudrun E. Moore -- Epigenetic factors in human obesity / Christopher G. Bell -- Epigenetic approaches to control obesity / Abigail S. Lapham ... [et al.] -- Epigenetics of diabetes in humans / Charlotte Ling and Tina Rönn -- The potential of epigenetic compounds in treating diabetes / Steven G. Gray -- Epigenetic aberrations in human allergic diseases / Manori Amaraseka ... [et al.] -- Therapy of airway disease: epigenetic potential / Peter J. Barnes -- The role of epigenetics in cardiovascular disease / Boda Zhou, Andriana Margariti and Qingbo Xu -- Epigenetics and human infectious diseases / Hans Helmut Niller and Janos Minarovits -- The epigenetics of endometriosis / Sun-Wei Guo -- Aberrant DNA methlylation in endometrial cancer / Kenta Masuda ... [et al.] -- Stem cell epigenetics and human disease / Mehdi Shafa and Derrick E. Rancourt -- Non-coding RNA regulatory networks, epigenetics, and programming stem cell renewal and differentiation: implications for stem cell therapy / Rajesh C. Miranda -- Aging and disease: the epigenetic bridge / Andrea Fuso -- Early-life epigenetic programming of human disease and aging / Alexander M. Vaiserman.
  • Epigenomics 2009
  • Epilepsy 2014
  • Section I. Scientific Foundations -- Chapter 1. Pathophysiological Mechanisms of Seizures and Epilepsy / Carl E. Stafstrom -- Chapter 2. Blood-Brain Barrier, Blood Flow, Neoplasms and Epilepsy / Luca Cucullo, Nicola Marchi, Vincent Fazio, Minh-Tri Nguyen, Damir Janigro -- Chapter 3. Metabolic Regulation of Seizures and Epileptogenesis / Manisha Patel -- Chapter 4. Brain Inflammation and Epilepsy / Teresa Ravizza, Silvia Balosso, Eleonora Aronica, Annamaria Vezzani -- Chapter 5. Drug Resistance in Epilepsy and Status Epilepticus / Jaideep Kapur, Edward H. Bertram -- Chapter 6. Epilepsy with Complex Genetics / Asuri N. Prasad, Chitra Prasad -- Chapter 7. Pathophysiology of Developmental Epilepsies / Judith L. Z. Weisenberg, Michael Wong -- Section II. Antiepileptic Drugs -- Chapter 8. Mechanisms of Antiepileptic Drug Action / Timothy A. Simeone -- Chapter 9. Epilepsy and Disease Modification: Animal Models for Novel Drug Discovery / H. Steve White -- Chapter 10. Pharmacogenetics of AED Development / Russell J. Buono, Thomas N. Ferraro, Dennis J. Dlugos, Karen S. Wilcox -- Chapter 11. Neuroprotective Strategies Using Antiepileptic Drugs / Patrick G. Sullivan, Ryan D. Readnower -- Chapter 12. Posttraumatic Seizures and Epileptogenesis / Christopher C. Giza -- Chapter 13. Possible Roles of Nonsynaptic Mechanisms in Synchronization of Epileptic Seizures / F. Edward Dudek, Li-Rong Shao, John E. Rash -- Chapter 14. A Mechanistic Approach to Antiepileptic Drug Interactions / Gail D. Anderson -- Section III. Epilepsy Surgery -- Chapter 15. Advances in Structural and Functional Neuroimaging / Hyunmi Kim, A. LeBron Paige, Robert C. Knowlton -- Chapter 16. Magnetoencephalography in Clinical Epilepsy / Jerry J. Shih, Michael P. Weisend -- Chapter 17. What Have We Learned from Resective Surgery in Pediatric Patients with Cortical Dysplasia? / Carlos Cepeda, Gary W. Mathern -- Chapter 18. Nonsurgical Ablation for Epilepsy / Erich O. Richter, Marina V. Abramova, William A. Friedman, Steven N. Roper -- Chapter 19. Deep Brain Stimulation for Epilepsy / Francisco Velasco, Ana Luisa Velasco, Luisa Rocha, Marcos Velasco, Jose D. Carrillo-Ruiz, Manoela Cuellar, Guillermo Castro, Fiacro Jimenez, David Trejo -- Chapter 20. Optical Imaging Techniques in Pediatric Neocortical Epilepsy / Daryl W. Hochman, Michael M. Haglund -- Chapter 21. High-Frequency Oscillations in Epileptic Brain / S. Matt Stead, Mark Bower, Greg Worrell -- Section IV. Alternative Therapies -- Chapter 22. Special Treatments in Epilepsy / Kevin Chapman, James W. Wheless -- Chapter 23. Herbs and Botanicals Steven C. Schachter -- Chapter 24. The Ketogenic Diet / Kristopher J. Bough, Carl E. Stafstrom -- Chapter 25. Vagus Nerve Stimulation / Matthew M. Troester, Dean K. Naritoku -- Chapter 26. Antiinflammatory Treatments for Seizure Syndromes and Epilepsy / Stéphane Auvin, Raman Sankar -- Section V. Other Modulators of the Epileptic State -- Chapter 27. Impact of Neuroendocrine Factors on Seizure Genesis and Treatment / Pavel Klein, Jaromir Janousek -- Chapter 28. Neurosteroid Replacement Therapy for Catamenial Epilepsy / Doodipala S. Reddy, Michael A. Rogawski -- Chapter 29. Chronobiology and Sleep / Mark Quigg -- Chapter 30. Pediatric Epilepsy / Rochelle Caplan -- Section VI. The Future of Epilepsy Therapy -- Chapter 31. Novel Mechanisms of Drug Delivery / Vijay Ivaturi, James Cloyd -- Chapter 32. Early Seizure Detection / Christophe C. Jouny, Piotr J. Franaszczuk, Gregory K. Bergey -- Chapter 33. Gene and Stem Cell Therapies for Treating Epilepsy / Janice R. Naegele, Xu Maisano -- Chapter 34. Arresting Epileptogenesis / Philip A. Schwartzkroin.
  • "Although epilepsy is one of the nation's most common neurological disorders, public understanding of it is limited. Many people do not know the causes of epilepsy or what they should do if they see someone having a seizure. Epilepsy is a complex spectrum of disorders that affects an estimated 2.2 million Americans in a variety of ways, and is characterized by unpredictable seizures that differ in type, cause, and severity. Yet living with epilepsy is about much more than just seizures; the disorder is often defined in practical terms, such as challenges in school, uncertainties about social situations and employment, limitations on driving, and questions about independent living. The Institute of Medicine was asked to examine the public health dimensions of the epilepsies, focusing on public health surveillance and data collection; population and public health research; health policy, health care, and human services; and education for people with the disorder and their families, health care providers, and the public. In Epilepsy Across the Spectrum, the IOM makes recommendations ranging from the expansion of collaborative epilepsy surveillance efforts, to the coordination of public awareness efforts, to the engagement of people with epilepsy and their families in education, dissemination, and advocacy for improved care and services. Taking action across multiple dimensions will improve the lives of people with epilepsy and their families. The realistic, feasible, and action-oriented recommendations in this report can help enable short- and long-term improvements for people with epilepsy. For all epilepsy organizations and advocates, local, state, and federal agencies, researchers, health care professionals, people with epilepsy, as well as the public, Epilepsy Across the Spectrum is an essential resource"--Publisher's description.
  • pt. 1. Introduction -- pt. 2. Generalized seizures -- pt. 3. Partial epilepsies -- pt. 4. Miscellaneous epilepsies -- pt. 5. Medical treatment -- pt. 6. Surgical epilepsy treatment -- pt. 7. Other aspects of epilepsy.
  • Written by expert epilepsy clinicians from the Mayo Clinic, Epilepsy Case Studies: Pearls for Patient Care presents a wide variety of case histories drawn from real life experiences in people with seizures. Designed to stimulate the same deductive reasoning that is commonly used when seeing epilepsy patients in the clinic, this practical book presents the clinical scenario and then poses a range of stimulating questions to organize the reader's thoughts to address each case. Questions that revolve around each case include common ones such as "How does this test help us with the diagnosis" and "What is the precise relationship of the patient's seizures to their overall neurological condition". The most poignant questions include "How does this information help us to devise a treatment plan?" and "What do we know about the anticipated course and prognosis?" The questions raised in each section incorporate the clinical course and evaluation. Where possible, the discussion relies upon the latest medical evidence to support the responses and includes up-to-date techniques used for patients with and without seizure control. At the end of each case a few salient citations are referenced, as are a few of the more pertinent articles that the reader can reference to obtain an overview of the topic.
  • Epilepsy, Part I, Basic Principles and Diagnosis, Volume 107, in the Handbook of Clinical Neurology series offers a comprehensive review of our knowledge of the field today, including epidemiology, basic mechanisms, animal models, and topics of increasing interest such as the role of inflammation in epilepsy. It provides a comprehensive approach to description of the clinical, electrographic and imaging aspects of the epilepsies, with a clear outline of contemporary classification and the role of modern diagnostic techniques, as well as neuropsychological and psychiatric aspects of epilepsy. Chapters are authored by internationally respected neurologists with varied perspectives insuring depth to the content. A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology. International list of contributors including the leading workers in the field. Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care.
  • Epilepsy Part II Treatment 2012
    Epilepsy, Part II, Treatment, Volume 108, provides a full description of epilepsy pathology and etiology, antiepileptic drug treatment, the approach to surgical evaluation and alternative procedures to be considered, in both children and adults, as well as brain stimulation and diet treatment. Economic and psychosocial issues such as stigma are fully covered. The special problems of epilepsy treatment in the developing world are described. Chapters are authored by internationally respected neurologists with varied perspectives insuring depth to the content. Epilepsy, Part I, Basic Principles and Diagnosis, Volume 107, establishes the scientific and practical diagnosis of epilepsy. The volumes will be a very important resource for basic scientists, clinical investigators, and all health professionals treating patients with epilepsy. *A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology. *International list of contributors including the leading workers in the field. *Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care.
  • Epilepsy syndromes 2010
    Epilepsy Seizures and Syndromes: Clinical Cases and Video-EEGs -- How To Use This Book -- Childhood Absence Epilepsy -- Juvenile Absence Epilepsy -- Juvenile Myoclonic Epilepsy -- Infantile Spasms/West Syndrome -- Lennox-Gastaut Syndrome -- Myoclonic Astatic Epilepsy -- Neonatal Seizures -- Landau-Kleffner Syndrome (Acquired Epileptic Aphasia) and Continuous Spike and Waves during Slow Wave Sleep Syndrome -- Benign Focal Epilepsy of Childhood with Centrotemporal Spikes -- Temporal Lobe Epilepsy -- Frontal Lobe Epilepsy -- Parietal Lobe Epilepsy -- Occipital Lobe Epilepsy -- Gelastic Seizures -- Evaluation for Epilepsy Surgery by the Epilepsy Team -- MRI and Epilepsy -- Nuclear Imaging and Epilepsy -- Neuropsychology in Epilepsy -- Intracarotid Sodium Amobarbital Procedure (the Wada Test) -- The Electrocorticogram -- Functional Mapping -- Surgical Treatment of Medically Intractable Epilepsy -- Pediatric Epilepsy Surgery -- Surgical Pathology of Epilepsy -- Psychogenic Nonepileptic Events -- Benign Neonatal Sleep Myoclonus and Benign Myoclonus of Early Infancy -- Self-Gratification Disorder in Children -- Reflex Infantile Syncopes (Breath Holding Spells) -- Discriminating Between Panic Disorder and Epilepsy -- Seizure versus Syncope -- Sleep Behaviors versus Epilepsy.
  • "Integrating the studies of epilepsy, neurosciences, computational neurosciences, mathematics, physics, engineering, and medicine, this volume provides the first means to a clear, structured, and enriching multidisciplinary perspective for developing students, researchers, and clinicians in the field of epilepsy. The text gives up to date information on the state of current research, possible future research, and clinical directions in the fields of epilepsy and seizure dynamics. Clear illustrations that illustrate the patterns of brain electrophysiology and behavioral manifestations are provided to aid comprehension. The authors include extensive references in each chapter to enhance further study"--Provided by publisher.
  • EEG generation and measurement -- Signal processing in EEG analysis -- Classifying the EEG -- Seizure detection -- Modeling for epilepsy -- On the predictability of seizures.
  • Epithelial cell culture protocols 2002
    Springer Protocols
  • 1. Chloride ATPase Pumps in Epithelia -- 2. Divalent Anion Transport in Crustacean and Molluscan Gastrointestinal Epithelia -- 3. Heavy Metal Transport and Detoxification by Crustacean Epithelial Lysosomes -- 4. Epithelial Calcium Transport in Crustaceans: Adaptation to Intrinsic and Extrinsic Stressors -- 5. The Cellular Basis of Extreme Alkali Secretion in Insects: A Tale of Two Tissues -- 6. H+, Na+, K+, and Amino Acid Transport in Caterpillar and Larval Mosquito Alimentary Canal -- 7. CFTR-Dependent Anion Transport in Airway Epithelia -- 8. Sulfate and Phosphate Transporters in Mammalian Renal and Gastrointestinal Systems -- 9. Role of H+-K+ ATPase, Na+-K+-2Cl⁻ and Na+-Cl⁻-HCO₃ ⁻ Transporters in Vertebrate Small Intestine -- 10. The H+- and H+, K+-ATPases of the Collecting Duct -- 11. Acid/Base Regulation in Renal Epithelia by H,K-ATPases -- 12. Sodium Transport Mechanisms in the Mammalian Nephron -- 13. Renal Acid-Base Regulation Via Ammonia Transport in Mammals -- 14. Hexose Transport Across Mammalian Epithelia -- 15. Amino Acid Transport by Epithelial Membranes -- 16. Molecular Ontology of Amino Acid Transport.
  • Epitope mapping protocols. 2nd ed. 2009
    Springer Protocols
    What is a B-cell epitope? / Marc H.V. Van Regenmortel -- Structural basis of antibody-antigen interactions / Eric J. Sundberg -- Epitope mapping of antibody-antigen complexes by nuclear magnetic resonance spectroscopy / Osnat Rosen and Jacob Anglister -- A solid-phase mutual inhibition assay with labeled antigen / Masahide Kuroki -- Epitope mapping by surface plasmon resonance / Pär Säfsten -- Proteolytic fragmentation for epitope mapping / Maria R. Mazzoni, Francesca Porchia, and Heidi E. Hamm -- Epitope mapping by proteolysis of antigen-antibody complexes / Suraj Dhungana ... [et al.] -- Identifying residues in antigenic determinants by chemical modification / Howard M. Reisner and Roger L. Lundblad -- Epitope mapping by differential chemical modification of antigens / Suraj Dhungana, Michael B. Fessler, and Kenneth B. Tomer -- Linear B-cell epitope mapping using enzyme-linked immunosorbent assay for libraries of overlapping synthetic peptides / Michael W. Heuzenroeder ... [et al.] -- Antibody epitope mapping using SPOT peptide arrays / Ulrich Reineke and Robert Sabat -- Peptide microarrays for profiling of modification state-specific antibodies / Johannes Zerweck, Antonia Masch, and Mike Schutkowski -- Epitope mapping using phage display peptide libraries / Volker Böttger and Angelika Böttger -- Antibody epitope mapping using de novo generated synthetic peptide libraries / Ulrich Reineke -- Antibody specificity profiling on functional protein microarrays / Dawn R. Mattoon and Barry Schweitzer -- Peptide microarrays for determination of cross-reactivity / Alexandra Thiele -- Epitope mapping using randomly generated peptide libraries / Juliane Bongartz, Nicole Bruni, and Michal Or-Guil -- Probing the epitope signatures of IgG antibodies in human serum from patients with autoimmune disease / Peter Lorenz ... [et al.] -- Microarrayed allergen molecules for diagnostics of allergy / Jing Lin, Ludmilla Bardina, and Wayne G. Shreffler -- Monitoring B cell response to immunoselected phage-displayed peptides by microarrays / Lina Cekaite, Eiving Hovig, and Mouldy Sioud -- Epitope mapping using homolog-scanning mutagenesis / Lin-Fa Wang -- Epitope mapping by region-specified PCR-mutagenesis / Tsutomu Mikawa, Masayuki Ikeda, and Takehiko Shibata -- Epitope mapping using phage-display random fragment libraries / Lin-Fa Wang and Meng Yu -- Prediction of linear B-cell epitopes / Ulf Reimer -- Molecular recognition of diverse ligands by T-cell receptors / Eric J. Sundberg -- Identification of human MHC class I binding peptides using the iTOPIA epitope discovery system / Markus Wulf, Petra Hoehn, and Peter Trinder -- T-cell epitope mapping in Mycobacterium tuberculosis using PepMixes created by micro-scale SPOT synthesis / Marisa Frieder and David M. Lewinsohn -- High-throughput T-cell epitope discovery through MHC peptide exchange / Sine Reker Hadrup ... [et al.] -- T-cell epitope processing (the epitope flanking regions matter) / Alejandra Nacarino Martinez, Stefan Tenzer, and Hansjörg Schild -- Identification of MHC class II binding peptides : microarray and soluble MHC class II molecules / Simani Gaseitsiwe and Markus J. Maeurer -- T-cell epitope mapping / Raija K.S. Ahmed and Markus J. Maeurer -- Identification and validation of T-cell epitopes using the IFN-[gamma] EliSpot assay / Markus Wulf, Petra Hoehn, and Peter Trinder.
  • v. 2 Springer
  • Introduction -- Exploitation -- Common heritage of humankind -- The altruism argument -- The "no value added" argument -- Justice and exploitation in bilateral exchanges -- Undue inducement and coercion -- Risks to indigenous peoples as vulnerable populations -- Closing chapter.
  • Also available: Print – 2010
  • Print Material
    How shall we improve human health? One answer is: by eradication. The Gates Foundation announced in 2007 that their goal is malaria eradication; another of their priorities is polio eradication. Eradication means the complete elimination of a disease through deliberate human intervention. It stands for an absolute in public health. This book by the award-winning historian of medicine Nancy Leys Stepan is an accessible, beautifully written, and deeply researched examination of one of the most controversial issues in public health today. The eradication of disease might seem like an absolute good. But critics of eradication argue that the huge resources needed to achieve eradication could be better allocated toward developing primary health services and general improvement in health. This book aims to look at the benefits and drawbacks of single-minded efforts to rid the world of particular diseases, one at a time. The sweep of the book is impressive, from the origins of the idea of complete eradication in the early twentieth century until the present-day campaigns against polio, Guinea worm disease, and now malaria. The author places eradication's story in its many contexts, from imperialism, changing notions of public health, the history of medicine and its technologies, the development of international health agencies such as the World Health Organization, and the impact of the Cold War on the shift of attention to disease in developing countries. -- Jacket.
  • This volume provides a comprehensive review of ERCP and EUS and the clinical conditions for which they are employed. Presented in a case-based format with accompanying videos, it will serve as a valuable practical clinical resource for gastroenterologists with an interest in ERCP and EUS. The text highlights major techniques involved in ERCP, reviews complications and recent data on preventing post-ERCP pancreatitis, and discusses important issues in ERCP training. The EUS chapters review the breadth of equipment available for performing EUS and EUS-FNA, detail the technique of performing EUS-FNA, and explore pertinent issues with training and assessing competency analogous to ERCP training. Valuable insights on the basics of cytopathology relevant to the endosonographer are summarized. The classic indication for EUS of staging luminal cancers is also examined in detail, while pancreaticobiliary indications are discussed highlighting newer adjunctive technologies including elastography and contrast-enhanced EUS. ERCP and EUS: A Case-Based Approach will serve as a very useful resource for physicians who perform or refer patients for ERCP and EUS. It provides a concise yet comprehensive summary of the current status of ERCP and EUS that will help guide patient management and stimulate clinical research. Supplementary video files are available for this book and can be accessed at
  • ERCP. 2nd ed. 2013
    Four Decades : The History of ERCP -- The ERCP Room -- Radiologic Issues and Radiation Safety during ERCP -- Endoscopes, Guidewires, and Accessories -- Sedation in ERCP -- Indications for and Contraindications to ERCP -- Adverse Events of ERCP : Prediction, Prevention, and Management -- ERCP Training -- Preparation for ERCP -- Principles of Electrosurgery -- Quality Issues and Measures in ERCP -- Medicolegal Issues in ERCP -- Cannulation of the Major Papilla -- Access (Precut) Papillotomy -- Sphincter of Oddi Manometry -- Biliary Sphincterotomy -- Balloon Dilation of the Native and Postsphincterotomy Papilla -- Stone Extraction -- Pancreatic Sphincterotomy -- Minor Papilla Cannulation and Sphincterotomy -- Plastic Pancreaticobiliary Stents and Nasopancreaticobiliary Tubes : Concepts and Insertion Techniques -- Biliary Metal Stent Insertion -- Pancreaticobiliary Stent Removal : Migrated and Nonmigrated -- Papillectomy and Ampullectomy -- Pancreatoscopy -- Cholangioscopy -- ERCP in Children -- ERCP in Pregnancy -- ERCP in Surgically Altered Anatomy -- Echoendoscopic Ultrasound-Guided Biliary Drainage -- Endoscopic Ultrasound-Assisted Access to the Pancreatic Duct -- Pancreas Divisum, Biliary Cysts, and Other Congenital Anomalies -- Approach to the Dilated Bile Duct and Pneumobilia -- The Dilated Pancreatic Duct -- Ampullary Neoplasia -- Malignant Biliary Obstruction : Distal -- Malignant Biliary Obstruction of the Hilum and Proximal Bile Ducts -- Indeterminate Biliary Stricture -- Combined Biliary and Duodenal Obstruction -- Benign Biliary Strictures -- Biliary Surgery Adverse Events Including Liver Transplantation -- ERCP for Acute and Chronic Adverse Events of Pancreatic Surgery and Pancreatic Trauma -- Choledocholithiasis -- Pancreaticobiliary Pain and Suspected Sphincter of Oddi Dysfunction -- Sclerosing Cholangitis -- Tropical Parasitic Infestations -- Recurrent Pyogenic Cholangitis -- Cystic Lesions of the Pancreas -- Unexplained Acute Pancreatitis -- Biliary Intervention in Acute Gallstone Pancreatitis -- Pancreatic Interventions in Acute Pancreatitis : Ascites, Fistulae, Leaks, and Other Disruptions -- Chronic Pancreatitis : Stones and Strictures -- Endoscopic Drainage of Pancreatic Pseudocysts, Abscesses, and Walled-Off (Organized) Necrosis.
  • This concise guide to the often overlooked association between erectile dysfunction and hypertension/cardiovascular disease covers a wide range of aspects of importance to the clinician. It examines the impact of antihypertensive drug therapy on erectile function and explains how the management of erectile dysfunction in hypertensive patients depends on a variety of factors. Different treatment approaches are described, including lifestyle modification, PDE-5 inhibitors and other novel agents, and behavioral therapy, and helpful therapeutic algorithms are presented. A further focus of the book is the potential role of erectile dysfunction as an early diagnostic indicator of asymptomatic coronary artery disease and a prognostic marker for cardiovascular events. In addition, key background information is supplied on epidemiology and pathophysiology, and the significance of erectile dysfunction in different patient groups, such as the elderly and those with chronic kidney disease, is examined. Erectile dysfunction is a major public health problem affecting more than ten percent of the general male population and is now considered to be predominantly of vascular origin. This book will be informative and of practical value for all practitioners responsible for caring for the very many patients who experience erectile dysfunction in the setting of hypertension and cardiovascular disease.
  • Ecological ergonomics / Marvin J. Dainoff -- Integrating cognitive and digital human models for virtual product design / Daniel W. Carruth and Vincent G. Duffy -- Time study during vocational training / Gregory Z. Bedny and Waldemar Karwowski -- The laws of ergonomics applied to design and testing of workstations / V.F. Venda, V.K. Kalin, and A.Y. Trofimov -- Day-to-day monitoring of an operator's functional state and fitness-for-work : a psychophysiological and engineering approach / Oleksandr Burov -- Identification of mental modules ; Identification of neural modules / Saul Sternberg -- The new interface of brain, mind, and machine : will the emergent whole be greater than the sum of the parts? / Chris Berka ... [et al.] -- The interaction of sleep and memory / Jeffrey M. Ellenbogen -- Attention, selection for action, error processing, and safety / Magdalena Fafrowicz and Tadeusz Marek -- Activity theory : comparative analysis of Eastern and Western approaches / Waldemar Karwowski, Gregory Z. Bedney, and Olexiy Y. Chebykin -- Discourse in activity / Harry Daniels -- Movements of the cane prior to locomotion judgments : the informer fallacy and the training fallacy versus the role of exploration / Gregory Burton and Jennifer Cyr -- Emotional intelligence : a novel approach to operationalizing the construct / E.L. Nosenko -- Emotional regulation of the learning process / Olexiy Y. Chebykin and S.D. Maksymenko -- Emotional resources of the professional trainer / G.V. Lozhkin -- Good judgment : the intersection of intelligence and personality / Robert Hogan, Joyce Hogan and Paul Barrett -- Relational self in action : relationships and behavior / Susan E. Cross and Kari A. Terzino.
  • Posture and movement -- Information and operation -- Environmental factors -- Work organization jobs and tasks -- The ergonomic approach -- Sources of additional information.
  • Print Material
  • Erosive tooth wear : a multifactorial condition of growing concern and increasing knowledge / A. Lussi, T.S. Carvalho -- Is erosive tooth wear an oral disease? / C. Ganss -- Diagnosis of erosive tooth wear / C. Ganss, A. Lussi -- The interaction between attrition, abrasion, and erosion in tooth wear / R.P. Shellis, M. Addy -- Challenges in assessing erosive tooth wear / V. Margaritis, J. Nunn -- Prevalence, incidence, and distribution of erosion / T. Jaeggi, A. Lussi -- Prevalence of erosive tooth wear in risk groups / N. Schlueter, A. Bjorg Tveit -- The histological features and physical properties of eroded dental hard tissues / C. Canss, A. Lussi, N. Schlueter -- Dentine hypersensitivity / N. West, J. Seong, M. Davies -- Methods for assessment of dental erosion / T. Attin, F.J. Wegehaupt -- Erosion in relation to nutrition and the environment / M.E. Barbour, A. Lussi -- Oral hygiene products, medications, and drugs -- hidden aetiological factors for dental erosion / E. Hellwig, A. Lussi -- Understanding the chemistry of dental erosion / R.P. Shellis, J.D.B. Featherstone, A. Lussi -- Intrinsic causes of erosion / R. Moazzez, D. Bartlett -- The potential of saliva in protecting against dental erosion / H.T. Hara, D.T. Zero -- The pellicle and erosion / M. Hannig, C. Hannig -- The role of oral hygiene : does toothbrushing harm? / A. Wiegand, N. Schlueter -- Risk assessment and causal preventive measures / A. Lussi, A. Hellwig -- The role of fluoride in erosion therapy / M.C. Huysmans, A. Young, C Ganss -- Alternatives to fluoride in the prevention and treatment of dental erosion / M.A.R. Buzalaf, A.C. Magalhaes, A. Wiegand -- Restorative therapy of erosive lesions / A. Peutzfeldt, T. Jaeggi, A. Lussi -- Erosive tooth wear in children / T.S. Carvalho, A. Lussi, T. Jaeggi, D.L. Gambon.
  • 1. Introduction / Raouf E. Nakhleh -- 2. The landscape of error in surgical pathology / Frederick A. Meier -- 3. General principles of how errors occur and how they may be reduced / Maxwell L. Smith, Stephen S. Raab -- Part 1. Pre-analytic factors contributing to errors and error prevention. 4. Error reduction in the pre-analytical process / Richard W. Brown -- 5. Application of lean principles to pre-analytic and analytic processes / Anil Vasdev Parwani, Seung Lyung Park, Liron Pantanowitz -- Part 2. Analytic factors contributing to errors and error prevention -- 6. Clinical history and clinical correlation / Keith E. Volmar -- 7. Knowledge, training, and experience / Amelia Huck, Vania Nosé -- 8. Standardization of diagnostic terminology and criteria: a prelude for error reduction / Raouf E. Nakhleh -- 9. Ancillary studies: contribution to error and error prevention / Paul E. Swanson -- 10. Optimization of case reviews in different practice settings / Raouf E. Nakhleh -- Part 3. Post-analytic factors leading to errors and error prevention. 11. The complete surgical pathology report / Michael O. Idowu -- 12. Communicating effectively in surgical pathology / Carolyn Mies -- 13. Error prevention in transcription and report distribution / Shannon J. McCall -- 14. Error management: legal and regulatory responsibilities / Timothy Craig Allen.
  • Also available: Print – 2006
    1. History and Biology of Erythropoietin in Hematopoietic and Non-Neural Tissues / Giorgia Melli, Sanjay Keswani and Ahmet Höke, p. 1-13 -- 2. Expression of Erythropoietin and Its Receptor in the Central Nervous System / Hugo Marti and Christian Bauer, p. 15-31 -- 3. Erythropoietin and Neuroprotection in the Central Nervous System: Intracellular Signaling Pathways / Murat Digicaylioglu, p. 33-48 -- 4. Regulation of Erythropoietin Expression in the Nervous System: The Hypoxia Inducible Factor / Juan Chavez and JoAnn Gensert, p. 49-67 -- 5. Erythropoietin Neuroprotection in the Term and Preterm Infant: Safety and Efficacy / Eric Demers and Sandra Juul, p. 69-98 -- 6. Erythropoietin for the Treatment of Acute Ischemic Stroke: Preclinical Rationale / Michael Renzi, Linda Jolliffe, Francis Farrell and Kenneth Rhodes, p. 99-112 -- 7. Erythropoietin Neuroprotection in the Retina / Gundula Rohde, Mathias Bähr and Jochen Weishaupt, p. 113-126 -- 8. Erythropoietin for Treatment of Human Brain Disease: Experience from Proof-of-Concept Trials / Hannelore Ehrenreich and Anna-Leena Sirén, p. 127-145 -- 9. Erythropoietin in Spinal Cord Injury Challenges for a Novel Neuroprotective Strategy / Michael Brines and Anthony Cerami, p. 147-164 -- 10. Erythropoietin and Neuroprotection in the Peripheral Nervous System: In Vivo Studies / W. Campana, p. 165-177 -- 11. An Endogenous Pathway Preventing Axonal Degeneration Mediated by Schwann Cell-Derived Erythropoietin / Sanjay Keswani and Ahmet Höke, p. 179-190 -- 12. Role of Erythropoietin in Inflammatory Pathologies of the CNS/ Pietro Ghezzi, Paolo Bigini and Manuela Mengozzi, p. 191-209 -- 13. Development of Non-Erythropoietic Erythropoietin Variants for Neuroprotection / Lars Torup and Marcel Leist, p. 211-219.
  • Erythropoiesis: an overview / B.E. Torbett and J.S. Friedman -- Regulation of endogenous erythropoietin production / D.R. Mole and P.J. Ratcliffe -- Biology of erythropoietin / G. Molineux and A.M. Sinclair -- Erythropoiesis - genetic abnormalities / J.T. Prchal and X.T. Gregg -- Studies of erythropoiesis and the discovery and cloning of recombinant human erythropoietin / M.A. Foote -- Commercial production of recombinant erythropoietins / A.S. Chuck ... [et al.] -- Biosimilar epoetins / H. Schellekens -- New molecules and formulations / S.G. Elliott -- Structural basis for the signal transduction of erythropoietin / T.D. Osslund -- Intracellular signaling by the erythropoietin receptor / H.F. Lodish ... [et al.] -- Mechanism of erythropoietin receptor activation / S.N. Constantinescu -- Pharmacokinetics of erythropoiesis-stimulating agents / S. Doshi ... [et al.] -- Use of erythropoietic stimulating agents in the setting of renal disease / D.A. Goodkin -- Abuse of recombinant erythropoietins and blood products by athletes / D.H. Catlin and C.K. Hatton -- Role and regulation of iron metabolism in erythropoiesis and disease / T.L. Arvedson and B.J. Sasu -- Nonhematopoietic effects of erythropoiesis-stimulating agents / W. Jelkmann, R. Depping and E. Metzen.
  • Prevention of cardiovascular disease -- Hypertension -- Diabetic heart disease -- Coronary heart disease -- Myocardial disease -- Pericardial disease -- Congenital heart disease -- Pregnancy and heart disease -- Valvular heart disease -- Infective endocarditis -- Pulmonary hypertension -- Arrhythmias -- Myocardial infarction -- Pulmonary embolism -- Heart failure -- Cardiac consult.
  • Print Material
  • The genomes of Escherichia coli K-12 and pathogenic E. coli / Nicole T. Perna, Jeremy D. Glasner, Valerie Burland and Guy Plunkett III -- Evolution of pathogenic Escherichia coli / James R. Johnson -- Enteropathogenic Escherichia coli / T. Eric Blank, Jean-Philippe Nougayrède and Michael S. Donnenberg -- Enterohemorrhagic and other shiga toxin-producing Escherichia coli / Cheleste M. Thorpe, Jennifer M. Ritchie and David W.K. Acheson -- Enterotoxigenic Escherichia coli / Eric A. Elsinghorst -- Enteroaggregative and diffusely adherent Escherichia coli / James P. Nataro and Theodore Steiner -- Shigella and enteroinvasive Escherichia coli : paradigms for pathogen evolution and host-parasite interactions / William A. Day and Anthony T. Maurelli -- Uropathogenic Escherichia coli / Farah Bahrani-Mougeot, Nereus W. Gunther IV, Michael S. Donnenberg and Harry L.T. Mobley -- Meningitis-associated Escherichia coli / Kwang Sik Kim -- Adhesive pili of the Chaperone-Usher family / James G. Bann, Karen W. Dodson, Carl Frieden and Scott J. Hultgren -- Type IV pili / W. Schreiber and Michael S. Donnenberg -- The LEE-encoded Type III secretion system in EPEC and EHEC : assembly, function, and regulation / J. Adam Crawford, T. Eric Blank and James B. Kaper -- Hemolysin / Vassilis Koronakis and Colin Hughes -- Capsule and lipopolysaccharide / Thomas A. Russo.
  • Print Material
  • Print Material
  • 1. Esophageal Anatomy and Physiology -- 2. Esophageal Diseases: Radiologic Images -- 3. Gastroesophageal Reflux Disease: Pathophysiology -- 4. Gastroesophageal Reflux Disease: Diagnostic Evaluation -- 5. Gastroesophageal Reflux Disease: Treatment -- 6. Treatment of Paraesophageal Hernias -- 7. Extra-Esophageal Manifestation of Gastroesophageal Reflux Disease -- 8.Epiphrenic Diverticulum -- 9. Evaluation and Treatment of Zenker's Diverticulum -- 10. Achalasia: Pathophysiology and Diagnostic Evaluation -- 11. Achalasia: Treatment -- 12.Begnign Esophageal Tumors: Evaluation and Treatment -- 13. Gastroesophageal Reflux Disease: From Heartburn to Cancer -- 14. Barrett's Esophagus: Treatment Options -- 15.Esophageal Cancer: Evaluation -- 16. Esophageal Cancer: Surgical Treatment -- 17. Esophageal Cancer: Neo-Adjuvant and Adjuvant Therapy.
  • Esophageal cancer causes an estimated 386,000 deaths worldwide and is the sixth most common cause of death for men. The background characteristics of esophageal cancer treatment are markedly different between Asian and Western countries, however. In tumor histology, squamous cell carcinoma associated with smoking and alcohol consumption is overwhelmingly prevalent in Asia, whereas adenocarcinoma associated with Barrett?s metaplasia is markedly prevalent in the West. In Asia, especially in Japan, the key persons who play important roles in the management of esophageal cancer patients are surgeons; in the West those roles are filled by medical and radiation oncologists as well as surgeons. The philosophy of surgeons regarding cancer surgery varies from locoregional to local tumor control, particularly in focusing on lymph node dissection. Physicians? approach to surgical adjuvant therapy differs, therefore, between Asia and the West. Considering these East?West differences in esophageal cancer treatment, the currently available results of Western evidence should not be considered directly applicable to esophageal cancer in Asia. In this book, the authors discuss the knowledge base in Japan in terms of treatment of esophageal squamous cell carcinoma. Since this volume contains a wide spectrum of current information and addresses topics surrounding the treatment of patients with esophageal squamous cell carcinoma, it is highly relevant to Asian physicians and researchers as well as to their counterparts in the West.
  • Print Material
    v. [1] 1908-1957 -- v. 2. 1958-1962.
  • Print Material
  • Print Material
  • Drs. Fleisher and Roizen present a completely revised new edition that includes coverage of many new conditions, procedures, and drugs. This book makes it easy to formulate anesthesia plans through a consistent format and discussions of the problems, causes, comorbidities, and anesthesia implications for over 600 clinical topics. Quickly reference key information using the carefully templated text that highlights the most important anesthetic considerations in a consistent, user-friendly layout. Stay current on the latest anesthetic implications in regards to coexisting diseases, procedures, drugs, and alternative and complementary therapies, including coverage of mitochondrial myopathy, atrial fibrillation ablation, awake craniotomy, stereotactic neurosurgery, neuroprotection, dexmedetomidine, and other hot topics. Master the core knowledge of Anesthesia and overcome new factors in anesthetic care of patients with trusted reference in a high yield format.
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    Epistemology -- Thermodynamics -- Information and noise -- Cellular signal -- Cancer metabolism -- Genomics -- Modulating noise in gene expression -- Involvement in carcinogenesis -- An ideal model of differentiation -- Conclusion.
  • Essence of memory 2008
  • pt. 1. Fundamentals of ultrasound in rheumatology -- pt. 2. Spectrum of ultrasound pathology -- pt. 3. Ultrasound in the diagnosis and management of rheumatic diseases -- pt. 4. Ultrasound techniques -- pt. 5. Training and education.
  • Print Material
    Introduction to biological databases -- Pairwise sequence alignment -- Database similarity searching -- Multiple sequence alignment -- Profiles and hidden Markov models -- Protein motifs and domain prediction -- Gene prediction -- Promoter and regulatory element prediction -- Phylogenetics basics -- Phylogenetic tree construction methods and programs -- Protein structure basics -- Protein structure visualization, comparision, and classification -- Protein secondary structure prediction -- Protein tertiary structure prediction -- RNA structure prediction -- Genome mapping, assembly, and comparison -- Functional genomics -- Proteomics.
  • Also available: Print – 2005
    Multivariable evaluation of candidates for cardiovascular disease / William B. Kannel -- Molecular and cellular basis of myocardial contractility / Arnold M. Katz -- Ventricular function / Lionel H. Opie -- Vascular function / Clive Rosendorff -- Thrombosis / Yale Nemerson and Mark B. Taubman -- The medical history and symptoms of heart disease / H.J.C. Swan -- Physical examination of the heart and circulation / Jonathan Abrams -- Electrocardiography / Tara L. DiMino ... [et al.] -- Echocardiography / Daniel G. Blanchard and Anthony N. DeMaria -- Exercise testing / Gregory Engel and Victor Froelicher -- Radiology of the heart / Gautham P. Reddy and Robert M. Steiner -- Cardiac catheterization and coronary angiography / Mark J. Ricciardi, Nirat Beohar, and Charles J. Davidson -- Nuclear imaging in cardiovascular medicine / Diwakar Jain and Barry L. Zaret -- Cardiovascular magnetic resonance and x-ray computed tomography / Gerald M. Pohost ... [et al.] -- Choosing appropriate imaging techniques / Jonathan E. E. Fisher and Martin E. Goldman -- Electrophysiology of cardiac arrhythmias / Sei Iwai ... [et al.] -- Treatment of cardiac arrhythmias / Davendra Mehta -- Syncope / Fei Lü, Scott Sakaguchi, and David G. Benditt -- Pathophysiology of heart failure / Mark Scoote, Ian F. Purcell, and Philip A. Poole-Wilson -- Treatment of congestive heart failure / Stephen S. Gottlieb -- Congenital heart disease / Julien I.E. Hoffman -- Pathogenesis of atherosclerosis / Prediman K. Shah -- Risk factors and prevention, including hyperlipidemias / Antonio M. Gotto, Jr. and John Farmer -- Coronary blood flow and myocardial ischemia / Robert J. Henning and Ray A. Olsson -- Stable angina / Satya Reddy Atmakuri, Michael H. Gollob, and Neal S. Kleiman -- Unstable angina and non-ST segment elevation myocardial infarction (acute coronary syndromes) / Satya Reddy Atmakuri and Neal S. Kleiman -- ST segment elevation myocardial infarction / Rajat Deo, Christopher P. Cannon, and James A. de Lemos -- Cardiopulmonary resuscitation / Joseph P. Ornato -- Rehabilitation after acute MI / Fredric J. Pashkow -- Rheumatic fever and valvular heart disease / Edmund A.W. Brice and Patrick J. Commerford -- Infective endocarditis / Adolf W. Karchmer -- Hypertension: mechanisms and diagnosis / Clive Rosendorff -- Hypertension therapy / Norman M. Kaplan -- Cardiomyopathies and myocarditis / Edward K. Kasper -- Pericardial disease / David H. Spodick -- Pulmonary vascular disease / Dermot O'Callaghan and Sean P. Gaine -- Diseases of the aorta / Eric M. Isselbacher -- Pregnancy and cardiovascular disease / Samuel C.B. Siu and Jack M. Colman -- Heart disease in the elderly / Michael W. Rich -- Cardiovascular complications in patients with renal disease / Richard A. Preston, Simon Chakko, and Murray Epstein -- Assessment of patients with heart disease for fitness for noncardiac surgery / Joseph Savino and Lee A. Fleisher -- Cardiovascular gene and cell therapy / Eddy Kizana ... [et al.] -- Preventive cardiology / Michael Miller -- Peripheral arterial disease / James J. Jang and Jonathan L. Halperin.
  • Multivariable Evaluation of Candidates for Cardiovascular Disease / Ralph B. D'Agostino Sr., William B. Kannel -- Molecular and Cellular Basis of Myocardial Contractility / Arnold M. Katz -- Ventricular Function / Lionel H. Opie -- Vascular Function / Rhian M. Touyz -- Thrombosis / Farzana R. Bacchus, Mark Crowther -- The History and Physical Examination of the Cardiovascular System / Rajat Gupta, Patrick O'Gara -- Electrocardiography / Tara L. DiMino, Alexander Ivanov, -- Echocardiography / Daniel G. Blanchard, Anthony N. DeMaria -- Exercise Testing / Abhimanyu (Manu) Uberoi, Shirin Zarafshar -- Radiology of the Heart / Christopher M. Walker, Gautham P. Reddy -- Cardiac Catheterization / Nirat Beohar, Mark J. Ricciardi -- Nuclear Imaging in Cardiovascular Medicine / Diwakar Jain, Barry L. Zaret, -- Cardiovascular Magnetic Resonance and Multidetector Computed Tomography / Gabriel Vorobiof, Norman Elliot Lepor, Mark Doyle -- Choosing Appropriate Imaging Techniques / Martin E. Goldman, Anthony F. Yu -- Electrophysiology of Cardiac Arrhythmias / Sei Iwai, Steven M. Markowitz, Bruce B. Lerman -- Treatment of Cardiac Arrhythmias / Suraj Kapa, Francis E. Marchlinski -- Syncope / Venkata Krishna Puppala, Scott Sakaguchi -- Pathophysiology of Heart Failure / Martin R. Cowie, -- Treatment of Congestive Heart Failure / Stephen S. Gottlieb -- Congenital Heart Disease / Matina Prapa, Dimitra Krexi, Anselm Uebing -- Pathogenesis of Atherosclerosis / Prediman K. Shah -- Coronary Blood Flow and Myocardial Ischemia / Brian R. Weil, John M. Canty Jr. -- Risk Factors and Prevention, Including Hyperlipidemia / Antonio M. Gotto Jr., John A. Farmer -- Stable Angina / Sachin Mehta, Neal Kleiman, -- Unstable Angina and Non-ST Segment Elevation Myocardial Infarction (Acute Coronary Syndromes) / Sachin Mehta, Neal Kleiman, -- ST-Segment Elevation Myocardial Infarction / Jonathan R. Enriquez, James A. de Lemos -- Cardiopulmonary Resuscitation / Joseph P. Ornato -- Cardiac Rehabilitation and Secondary Prevention After Acute MI / Arthur S. Leon -- Rheumatic Fever and Valvular Heart Disease / Blanche J. Cupido -- Infective Endocarditis / Adolf W. Karchmer -- Hypertension: Mechanisms and Diagnosis / Clive Rosendorff -- Hypertension Therapy / Norman M. Kaplan, Odelia Cooper, Ronald G. Victor -- Cardiomyopathies and Myocarditis / Colleen M. Harrington, Edward K. Kasper, -- Pericardial Disease / Bernhard Maisch -- Pulmonary Vascular Disease / Eoin P. Judge, Dermot O'Callaghan, Sean P. Gaine -- Diseases of the Aorta / David M. Dudzinski, Eric M. Isselbacher -- Cardiovascular Disease in Women / Benjamin D. Mackie, Nanette Kass Wenger, -- Pregnancy and Heart Disease / T. P. E. Ruys, Mark R. Johnson -- Heart Disease in the Elderly / Michael W. Rich -- Cardiovascular Complications in Patients with Renal Disease / Sheldon W. Tobe -- Diabetes and the Cardiovascular System / Paul Cohen, Jorge Plutzky -- Cancer Therapy-Induced Cardiomyopathy / Peter Kim, Pimprapa Vejpongsa, Edward T. H. Yeh -- Assessment of Patients with Heart Disease for Fitness for Noncardiac Surgery / Lee A. Fleisher, Joseph S. Savino -- Cardiovascular Gene Therapy / Thomas J. LaRocca, Roger J. Hajjar -- Cardiovascular Cell Therapy / Annarosa Leri, Jan Kajstura, Marcello Rota -- Preventive Cardiology / Temilolu O. Aje, Michael Miller -- Peripheral Arterial Disease / Giovina Lara Bomba, Jonathan L. Halperin.
  • Informed Consent -- Standard Precautions -- Sterile Technique -- Blood Pressure Measurement -- Venipuncture -- Obtaining Blood Cultures -- Inserting Intravenous Catheters -- Arterial Puncture -- Injections -- Recording an Electrocardiogram -- Exercise Stress Testing -- Endotracheal Intubation -- Office Pulmonary Function Testing -- Nasogastric Tube Placement -- Lumbar Puncture -- Urinary Bladder Catheterization -- Urinary Bladder Catheterization -- Epistaxis and Nasal Foreign Body Removal -- The Pelvic Examination and Obtaining a Routine Papanicolaou Smear -- Reduction of the Shoulder/Finger Subluxations -- Joint and Bursal Aspiration -- Casting and Splinting -- Local Anesthesia -- Wound Closure -- Dermatologic Procedures -- Incision and Drainage of an Abscess -- Wound Dressing Techniques -- Cryosurgery -- Treating Ingrown Toenails -- Draining Subungual Hematomas -- Anoscopy -- Flexible Sigmoidoscopy -- Removal of Cerumen and Foreign Bodies from the Ear -- Trauma-Oriented Ocular Examination, Corneal Abrasion, and Ocular Foreign Body Removal -- Endometrial Biopsy -- Foot Examination of the Patient with Diabetes -- Procedural Sedation -- Patient Education Concepts * -- Outpatient Coding for Medical Services -- Documentation -- Giving Sad and Bad News.
  • Toxicogenomics and classical toxicology, how to improve prediction and mechanistic understanding of human toxicity / Donna L. Mendrick -- Use of traditional endpoints and gene dysregulation to understand mechanisms of toxicity / Wayne R. Buck, Jeffrey F. Waring, Eric A. Blomme -- Quality control of microarray assays for toxicogenomic and in vitro diagnostic applications / Karol L. Thompson and Joseph Hackett -- Role of statistics in toxicogenomics / Michael Elashoff -- Predictive toxicogenomics in preclinical discovery / Scott A. Barros and Rory B. Martin -- In vivo predictive toxicogenomics / Mark W. Porter -- Bioinformatics, databasing and gene annotation / Lyle D. Burgoon and Timothy R. Zacharewski -- Microarray probe mapping and annotation in cross - species comparative toxicogenomics / John N Calley, William B Mattes, Timothy P. Ryan -- Toxicogenomics in biomarker discovery -- Marc F. DeCristofaro, Kellye K. Daniels -- From pharmacogenomics to translational biomarkers / Donna L. Mendrick -- Public consortium efforts in toxicogenomics / William B. Mattes -- Applications of toxicogenomics to nonclinical drug development / Frank D. Sistare, Joseph J. DeGeorge.
  • Also available: Print – 2007
    Echocardiographic instumentation and principles of doppler echocardiography / Scott D. Solomon -- Introduction to imaging: the normal examination / Dara Lee and Scott D. Solomon -- Protocol and nomenclature in transthoracic echocardiography / Bernard E. Bulwer and Jose Rivero -- Clinical utility of echocardiography / Bernard E. Bulwer, Faisal Shamshad, and Scott D. Solomon -- Echocardiographic assessment of ventricular systolic function / Bernard E. Bulwer, Scott D. Solomon, and Rajesh Janardhanan -- Echocardiographic assessment of diastolic function / Carolyn Y. Ho -- Echocardiography in myocardial infarction / Justina C. Wu -- Stress echocardiography : indications, protocols, and interpretation / Edmund A. Bermudez and Ming Hui Chen -- Cardiomyopathies / Bernard E. Bulwer and Scott D. Solomon -- Pericardial disease / Ashvin N. Pande and Leonard S. Lilly -- Echocardiographic assessment of aortic stenosis / Edmund A. Bermudez -- Echocardiographic evaluation of aortic regurgitation / Susan M. Sallach and Sharon C. Reimold -- Mitral stenosis / Robert J. Ostfeld -- Mitral regurgitation / Jacqueline Suk Danik and Bernard E. Bulwer -- Infective endocarditis / Nagesh S. Anavekar, Marcus Averbach, and Bernard E. Bulwer -- Role of echocardiography in the management of atrial fibrillation / Warren J. Manning -- Cardiac source of embolus / Justina C. Wu -- Echocardiography in pulmonary embolism and secondary pulmonary hypertension / David Aguilar and Bernard E. Bulwer -- Cardiac masses and tumors / Justina C. Wu -- Aortic dissection and other diseases of the aorta / Laura Benzaquen -- Echocardiography in the assessment of artrial septal defects / Edmund A. Bermudez -- Adult congenital heart disease in general echocardiography practice : an introduction / Bernard E. Bulwer and Michael J. Landzberg -- Transesophageal echocardiography multiplane examination primer / Bernard E. Bulwer and Stanton K. Shernan.
  • This book is a step-by-step manual for the complete echo-novice. The text focuses on the practicalities of performing an examination, and the interpretation of images. Avoiding unnecessary technicalities, it places particular emphasis on the diagnostic features of sample cases and covers the entire breadth of adult cardiology. The majority of the echo images are also available in a dynamic form on the Expert Consult platform. Also included is access to 100 case scenarios and images for self-assessment interpretation. Trainees in cardiology, echocardiography/cardiac physiology, anaesthetics, intensive care, general medicine, acute medicine, accident and emergency and cardiothoracic surgery.
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    The endocrine system -- The biological principles of endocrinology -- The molecular basis of endocrinology -- Investigations in endocrinology -- The hypothalamus and pituitary gland -- The adrenal gland -- Reproductive endocrinology -- The thyroid gland -- Calcium and metabolic bone disease -- Endocrine neoplasia -- Overview of diabetes -- Type 1 diabetes -- Type 2 diabetes -- Complications of diabetes -- Obesity.
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    The genetic code of genes and genomes -- Transmission genetics: heritage from Mendel -- The chromosomal basis of heredity -- Gene linkage and genetic mapping -- Human chromosomes and chromosome behavior -- DNA structure, replication, and manipulation -- The genetics of bacteria and their viruses -- The molecular genetics of gene expression -- Molecular mechanisms of gene regulation -- Genomics, proteomics, and genetic engineering -- The genetic control of development -- Molecular mechanisms of mutation and DNA repair -- Molecular genetics of the cell cycle and cancer -- Molecular evolution and population genetics -- The genetic basis of complex inheritance.
  • Schematic presentation of the hemostatic system / Nils Egberg -- Proposals for sampling instructions / Margareta Blombäck and Nils Egberg -- Laboratory investigations / Jovan P. Antovic, Liselotte Onelöv, and Nils Egberg -- Hereditary bleeding disorders / Margareta Holmström and Lars-Göran Lundberg -- Critical bleeding / Maria Bruzelius, Anna Ågren, and Hans Johnsson -- Investigation of increased bleeding tendency / Margareta Holmström and Lars Göran Lundberg -- Venous thrombosis and pulmonary embolism / Anders Carlsson -- Investigations of thromboembolic tendency / Margareta Holmström -- Heart disease / Håkan Wallen and Rickard Linder -- Antiplatelet drug therapy and reversal of its effects / Håkan Wallen, Hans Johnsson, and Bo-Michael Bellander -- New oral anticoagulants : focus on currently approved oral factor Xa and thombin inhibitors / Rickard E. Malmström and Hans Johnsson -- Stroke and transient ischemic attack / Nils Wahlgren and Mia von Euler -- Peripheral artery surgery / Jesper Swedenborg -- Hemostasis in obstetrics and gynecology / Katarina Bremme -- Hemostasis in children / Susanna Ranta and Pia Petrini -- Emergency conditions associated with coagulation : DIC, HIT, and TTP/HUS / Jovan P. Antovic and Margareta Holmström.
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  • This concise, easy-to-follow text gives an insight into core techniques and practices in biomedical research and how, when and why a technique should be used and presented in the literature. Readers are alerted to common failures and misinterpretations that may evade peer review and are equipped with the judgment necessary to be properly critical of the findings claimed by research articles. --from publisher description
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  • This book offers an excellent review of the various rheumatological conditions, both common and uncommon, that may present on imaging on a daily basis. The book uses a unique format that will be beneficial for clinicians, radiologists, medical students, and consultant staff. The text is written by both rheumatology and radiology staff to provide a balanced approach. A clinical overview and the common clinical presentations are briefly reviewed for each condition followed by a more detailed discussion of imaging findings produced by the various imaging modalities, including radiographs, ultrasound, MRI, CT, and nuclear medicine. This book details the imaging of normal musculoskeletal anatomy and pathology; discusses image-guided musculoskeletal interventions; and examines disorders such as rheumatoid arthritis, connective tissue disease, osteoarthritis, osteonecrosis, infection-related arthritis, soft tissue calcification, and bone and synovial tumors. Featuring over 600 multi-part, high-resolution images of rheumatic diseases across current imaging modalities, Essential Imaging in Rheumatology offers up-to-date and complete information on the imaging of these disorders.
  • Part I. Upper Respiratory Tract Infections -- 1. Clinical guidelines: community acquired pneumonia / John Russell -- 2. Pharyngitis / Adrian Wilson -- 3. Treatment and management of acute otitis media / Ross H. Albert and Neil S. Skolnik -- 4. Management of chronic obstructive pulmonary disease exacerbations and acute bronchitis / Michael Gagnon -- 5. Latent tuberculosis infection: testing and treatment / Pamela Ann Fenstemacher -- 6. Sinusitis / Megan Werner and Mathew Clark -- Part II. Gastrointestinal Infections -- 7. Gastroenteritis / Andrew Deroo and Matthew Mintz -- 8. Hepatitis / Michele Lamoreux -- III. Sexually Transmitted Diseases -- 9. Sexually transmitted diseases / Neil Skolnik -- 10. Human immunodeficiency virus / Rosemary Harris -- IV. Skin, Bone, and Joint Infection -- 11. Cellulitis and skin infections associated with bites / Steven Zinn and Judith O'Donnell -- 12. Diabetic foot infections / Thomas C. McGinley Jr. -- 13, Osteomyelitis / Kelly Gannon and Todd Braun -- 14. Septic arthritis and infectious bursitis / Gene Hong and Nirandra Mahamitra -- 15. Lyme disease prevention, diagnosis, and treatment / Ross Albert and Neil Skolnik -- V. Other Infectious Disease Topics -- 16. Infective endocarditis / Tina Degnan and Neil Skolnik -- 17. Meningitis / Anne T. Wiedemann -- 18. Urinary tract infections / Jennifer Neria and Matthew Mintz -- 19. Adult immunizations / John Russell and Ross Albert -- 20. Clinical ethics and infectious disease in family medicine / Janet Fleetwood.
  • This title is directed primarily towards health care professionals outside of the United States. This book has been prepared by professionals working in the UK. It covers the basic principles and practice of interventional cardiology, vascular and non-vascular, written specifically for the general cardiologist. Designed to facilitate easy access to key information, it contains numerous line illustrations, diagrams, graphs, and charts. The entire spectrum of interventional cardiology is covered in an easy-to-read format. In this new edition are fifteen new chapters written by experts from around the world. The excellent appendix of trials in interventional cardiology has been fully updated making this the best available source on how to apply trials to clinical practice. Includes editors and contributors from the US and Europe for a truly international perspective. Begins each chapter with 6-10 key points written in bullet format that summarize important concepts in the chapter, making reference a snap.
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  • Medical facts, errors, and this book -- Challenging current medical misconception -- Epidemiologic realities and gee-whiz facts -- Disease prevention and screening -- Risk factors and disease correlates -- Practical clinical pearls -- Laboratory testing, electrocardiography and imaging -- Alarming symptoms and red flag findings -- Therapeutic insights -- Idiosyncratic and uncommon drug effects -- Drug Interactions and adventures in polypharmacy -- Alcohol, nicotine and caffeine -- Unforeseen, counterintuitive and possibly prophetic findings -- Unforeseen, counterintuitive and possibly prophetic findings -- Some timeless truths about medical practice -- A clinican's glossary of statistical terms.
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  • 2011 ClinicalKey
    Neuromodulation is an emerging field that explores the use of electrical, chemical, and mechanical interventions to heal neurological deficits. Such neurostimulation has already shown great promise with disorders and diseases such as chronic pain, epilepsy, and Parkinson's disease. This is the first concise reference covering all of the basic principles of neuromodulation in a single affordable volume for neuro-residents, fellows, and basic clinical practitioners, edited by two prominent clinical experts in the field. This volume emphasizes essential observations from all of the important clinical phases involved in any neuromodulation: targeting, intraoperative assessment, programming, complications, and complication avoidance. There are commonalities to all neuromodulation procedures that must be brought to the forefront to form a cohesive presentation of neuromodulation, and such emphasis will give readers a more solid grounding in the fundamentals needed to embrace this field as a cohesive clinical entity.
  • Essential neurosurgery companion 2013
    Thieme eNeurosurgery
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    Basic nuclear medicine physics -- Interaction of radiation with matter -- Formation of radionuclides -- Nonscintillation detectors -- Nonimaging scintillation detectors -- Imaging instrumentation -- Single-photon emission computed tomography (SPECT) -- Positron emission tomography (PET) -- Combined PET/CT imaging -- Quality control -- Radiation biology -- Radiation dosimetry -- Radiation safety -- Management of nuclear event casualties.
  • Anatomy of the female pelvis / Caroline de Costa -- Conception and nidation / Roger Pepperell -- Physiological changes in pregnancy / Fiona Broughton Pipkin -- Placental and fetal growth and development / E. Malcolm Symonds -- Perinatal and maternal mortality / Boon H. Lim -- History taking and examination in obstetrics / Edwin Chandraharan -- Normal pregnancy and antenatal care / Shaylee Iles -- Obstetric disorders / Henry G. Murray -- Maternal medicine / Suzanne V.F. Wallace, Henry G. Murray and David James -- Assessment of fetal wellbeing / David James and Suzanne V.F. Wallace -- Management of labour / Sabaratnam Arulkumaran -- Management of delivery / Aldo Vacca -- Postpartum problems / Shankari Arulkumaran -- Psychiatric disorders of childbirth / Margaret R. Oates -- Basic clinical skills in gynaecology / Ian M. Symonds -- Gynaecological disorders / Ian S. Fraser -- Infertility / William Ledger -- Early pregnancy care / Ian M. Symonds -- Sexual and reproductive health / Roger Pepperell -- Gynaecological oncology / Hextan Y.S. Ngan and Karen Chan -- Prolapse and disorders of the urinary tract / Ajay Rane and Jay Iyer.
  • Introduction -- Essential oil composition -- Toxicity -- Kinetics and dosing -- The skin -- The respiratory system -- The cardiovascular system -- The urinary system -- The digestive system -- The nervous system -- The reproductive system -- Cancer and the immune system -- Essential oil profiles -- Constituent profiles -- General safety guidelines.
  • Essential orthopaedics 2010
    Noted authority Mark D. Miller, MD, together with a stellar editorial team and numerous contributors representing a breadth of specialty areas within orthopaedics and primary care, offers you the comprehensive, multidisciplinary insight you need to confidently diagnose and treat sprains, fractures, arthritis and bursitis pain, and other musculoskeletal problems, or refer them when appropriate. Videos on DVD demonstrate how to perform 29 joint injections, 7 common physical examinations, a variety of tests, and 6 splinting and casting procedures. Presents multidisciplinary coverage that provides authoritative orthopaedic guidance oriented towards the practical realities of primary care practice.
  • Also available: Print – 2009
    Introduction -- History and clinical examination -- Orthopaedic anatomy -- Basic science in orthopaedics -- Investigations -- Methods of treatment -- The principles of managing trauma -- Immediate care and major incidents -- Methods of managing trauma -- Injuries to the face, head and spine -- Injuries to the trunk -- Injuries to the upper limb -- Hand injuries -- Injuries to the lower limb -- Sports injuries -- Osteoarthritis -- Rheumatoid arthritis and other arthropathies -- Bone and joint infections -- Metabolic disease, dysplasias, osteochondritis, and neurological disorders -- Granulomatous disorders and tumours -- Deformities in children -- Disorders of the shoulder and elbow -- Disorders of the wrist and hand -- Disorders of the hip and knee -- Disorders of the ankle and foot -- Disorders of the spine.
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    Anatomy of the ear / K. J. Lee -- Audiology / Kathleen C. M. Campbell, James E. Peck, and K. J. Lee -- Electrical response audiometry / Derald E. Brackmann, Manuel Don, and Weldon Selters -- The vestibular system / Charles C. Della Santina, Lloyd B. Minor, and John P. Carey -- Congenital hearing loss / K. J. Lee and Seilesh C. Babu -- Cochlear implants / Richard T. Miyamoto -- Skull base surgery / Paul J. Donald and Hilary A. Brodie -- Facial nerve paralysis / Elizabeth H. Toh and K. J. Lee -- Syndromes and eponyms / K. J. Lee and Mark Lee -- Embryology of clefts and pouches / K. J. Lee and Jay Farrior -- Cleft lip and palate / Eric J. Moore and Craig W. Senders -- Infections of the ear / Sarah S. Connell and Thomas J. Balkany -- Noninfectious disorders of the ear / Jay Farrior and K. J. Lee -- The nose and paranasal sinuses / Martin J. Citardi and Pete S. Batra -- The paranasal sinuses: embryology, anatomy, endoscopic diagnosis, and treatment / David W. Kennedy and Bradford A. Woodworth -- Obstructive sleep apnea / Jean M. Bruch and Nicolas Y. Busaba -- Immunology and allergy / John Houck -- Salivary gland diseases / Robert L. Witt -- The oral cavity, pharynx, and esophagus / David E. Eibling -- The larynx / Gayle E. Woodson and Ninef E. Zaya -- Neck spaces and fascial planes / Nilesh R. Vasan -- Thyroid and parathyroid glands / Ralph P. Tufano, Chad A Glazer, and Gregory W. Randolph -- Cysts and tumors of the jaws / John P. Kelly -- Carotid body tumors and vascular anomalies / Nilesh R. Vasan and Greg A. Krempl -- TNM classification in otolaryngology----head and neck surgery / Thomas G. Takoudes -- Malignant melanoma / Greg Krempl -- Cancer of the larynx, paranasal sinuses, and temporal bone / Nilesh R. Vasan -- Carcinoma of the oral cavity, pharynx, and esophagus / James P. Malone and K. Thomas Robbins -- Reconstructive head and neck surgery / Mark Delacure -- Facial plastic surgery / Tessa Hadlock and Mack L. Cheney -- Pediatric otolaryngology / Kathleen Sie -- Anesthesia for head and neck surgery / K. J. Lee -- Surgical hemostasis and clotting mechanisms / John E. Godwin and Raghu Kolluri -- Chemotherapy of head and neck cancer / Harold Tara and Bruce Lundberg -- Related neurology and neurosurgery / Isaac Goodrich, James C. McVeety, and K. J. Lee -- Related ophthalmology / K. J. Lee -- The chest / K. J. Lee -- Fluid, electrolytes, and nutrition / K. Chris McMains and Frank R. Miller -- Antimicrobial therapy in otolaryngology----head and neck surgery / David N. F. Fairbanks -- Pharmacology and therapeutics / Mark D'Agostino, K. J. Lee -- Highlights and pearls / Ryan B. Scannell and K. J. Lee.
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  • Also available: Print – 2006
    Traumatic brain injury / Ramnik Singh and Michael W. O'Dell -- Stroke / Brenda S. Mallory -- Spinal cord injury / Monifa Brooks and Steven Kirshblum -- Prosthetics and orthotics / Heikki Uustal -- Cardiac rehabilitation / Mathew N. Bartels -- Pulmonary rehabilitation / Mathew N. Bartels -- Pediatric rehabilitation / Jilda N. Vargus-Adams -- Neuromuscular rehabilitation / Nancy E. Strauss, Shikha Sethi, and Stanley J. Myers -- Cancer rehabilitation / Michael D. Stubblefield and Christian M. Custodio -- Orthopedic rehabilitation / C. David Lin -- Spine and musculoskeletal medicine / Grant Cooper, Yusuf Tatli, and Gregory E. Lutz -- Electrodiagnostic medicine / Joseph Feinberg ... [et al.].
  • The basic science important to nuclear imaging, including the nature and production of radioactivity, internal dosimetry and radiation detection and measurement, are presented clearly and concisely. Current concepts in the fields of radiation biology and radiation protection relevant to medical imaging, and a number of helpful appendices complete this comprehensive textbook. The text is enhanced by numerous full color charts, tables, images and superb illustrations that reinforce central concepts. The book is ideal for medical imaging professionals, and teachers and students in medical physics and biomedical engineering. Radiology residents will find this text especially useful in bolstering their understanding of imaging physics and related topics prior to board exams."--pub. desc.
  • Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment Of High Blood Pressure / Benjamin J. Epstein -- Hyperlipidemia / Andrew Cohen and Neil S. Skolnik -- Management of newly diagnosed atrial fibrillation: a clinical practice guideline from the American Academy of Family Physicians and the American College of Physicians / Jaya Udayasankar and Doron Schneider -- Antithrombotic therapy for venous thromboembolic disease / George P.N. Samraj -- Antithrombotic therapy for atrial fibrillation, valvular heart disease, management of elevated INRs and perioperative management / Ann Peff and Doron Schneider -- Prevention of bacterial endocarditis / Margot Boigon and Doron Schneider -- Clinical guidelines for the diagnosis and treatment of asthma / Michael Gagnon and Neil S. Skolnik -- Community acquired pneumonia and health-care associated pneumonia clinical guidelines / John Russell -- Diagnosis and management of otitis media: joint guidelines from the American Academy of Pediatrics and American Academy of Family Physicians / Richard Neill -- Appropriate antibiotic use for treatment of nonspecific upper respiratory infections, rhinosinusitis, and acute bronchitis in adults / Tina H. Degnan and Neil S. Skolnik -- Group A streptococcal pharyngitis: the Infectious Disease Society of America / Mario Napoletano -- Prevention of perinatal group B streptococcal disease / Ross Albert, Neil S. Skolnik, and Richard Neill -- Adult immunizations / Brett Fissell and Neil S. Skolnik -- Rabies prevention / Doron Schneider -- Practice guidelines for the management of infectious diarrhea / Pam Fenstemacher -- Tuberculosis testing and treatment of latent infection / Pam Fenstemacher -- Sexually transmitted diseases treatment guidelines, 2006 / Neil S. Skolnik -- Updated US public health service guidelines for the management of occupational exposure to HBV, HCV, and HIV and recommendations for postexposure prophylaxis / David Gary Smith -- Screening for osteoporosis in postmenopausal women / Richard Neill -- Managing abnormal cervical cytology and cervical intraepithelial neoplasia: 2001 consensus guidelines / Amy Clouse -- Dementia / William McCarberg -- Diagnosis and treatment of migraine headaches / Richard Neill -- Concussion guidelines in athletes / David Webner -- Restless legs syndrome / Matthew Clark -- Depression: pharmacological treatment / John E. Sutherland -- Diagnosis, evaluation, and treatment of the school-aged child with attention deficit hyperactive disorder / Richard Neill -- Practice guidelines for the treatment of patients with delirium / Mary Hofmann and Doron Schneider -- Panic disorder / Diane Dietzen and Doron Schneider.
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  • Introduction to radiology -- The circulatory system: the heart and great vessels -- The respiratory system -- The digestive system -- The urinary tract -- The acute abdomen -- The reproductive system -- The musculoskeletal system -- Neuroimaging -- Pediatric radiology.
  • Knee injuries / Melanie A. Hopper and Andrew J. Grainger -- Hip, pelvis, and groin injuries / Philip Robinson -- Ankle and foot injuries / Ne Siang Chew ... [et al.] -- Osseous stress injury in athletes / Melanie A. Hopper and Philip Robinson -- Shoulder injuries / Andrew J. Grainger and Philip F.J. Tirman -- Elbow injuries / Kenneth S. Lee, Michael J. Tuite, and Humberto G. Rosas -- Hand and wrist injuries / Philip J. O'Connor -- Postoperative imaging in sports medicine / Ali Naraghi and Lawrence M. White -- Muscle injury and complications / Abhijit Datir and David A. Connell -- Sports-related disorders of the spine and sacrum / Rob Campbell and Andrew Dunn -- Ultrasound-guided sports intervention / Philip J. O'Connor.
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  • Oncogene addiction is thought to occur cell autonomously. Immune effectors are implicated in the initiation and restraint of tumorigenesis, but their role in oncogene inactivation-mediated tumor regression is unclear. Here, we show that an intact immune system, specifically CD4+ T cells, is required for the induction of cellular senescence, shutdown of angiogenesis, and chemokine expression resulting in sustained tumor regression upon inactivation of the MYC or BCR-ABL oncogenes in mouse models of T cell acute lymphoblastic lymphoma and pro-B cell leukemia, respectively. Moreover, immune effectors knocked out for thrombospondins failed to induce sustained tumor regression. Hence, CD4+ T cells are required for the remodeling of the tumor microenvironment through the expression of chemokines, such as thrombospondins, in order to elicit oncogene addiction.
  • Essential simulation in clinical education / Judy McKimm and Kirsty Forrest -- Medical simulation : the journey so far / Aidan Byrne -- The evidence what works, why and how? / Doris Ostergaard and Jacob Rosenberg -- Pedagogy in simulation-based training in health care / Peter Dieckmann and Charlotte Ringsted -- Assessment / Thomas Gale and Martin Roberts -- The roles of faculty and simulated patients in simulation / Bryn Baxendale, Frank Coffey, and Andrew Buttery -- Surgical technical skills / Rajesh Aggarwal and Amit Mishra -- The non-technical skills / Nikki Maran, Simon Edgar, and Alistair May -- Teamwork / Jennifer Weller -- Designing effective simulation activities / Joanne Barrott ... [et al.] -- Distributed simulation / Jessica Janice Tang ... [et al.] -- Providing effective simulation activities / Walter J Eppich, Lanty O'Connor, and Mark Adler -- Simulation in practice / edited by Jean Keri -- The future for simulation.
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    This text presents a detailed introduction to SQLAlchemy, the code library for Python users that makes it easier to access popular databases such as Oracle and MySQL. It demonstrates how to use the library to create simple database applications, and walks readers through simple queries.
  • Mechanisms of surgical disease and surgery in practice -- Managing physiological change in the surgical patient -- Immunity, inflammation and infection -- Shock and resuscitation -- Imaging and interventional techniques in surgery -- Screening for adult disease -- Preoperative assessment -- Medical problems -- Blood transfusion -- Principles and techniques of operative surgery including neurosurgery and orthopaedics -- Diagnosis and management of common postoperative problems -- Complications of surgery -- Principles of cancer management -- Principles of transplantation surgery -- Major trauma -- Head and maxillofacial injuries -- Soft tissue injuries and burns -- Non-acute abdominal pain and other abdominal symptoms and signs -- The acute abdomen and acute gastrointestinal haemorrhage -- Gallstone diseases and related disorders -- Peptic ulceration and related disorders -- Disorders of the oesophagus -- Tumours of the stomach and small intestine -- Tumours of the pancreas and hepatobiliary system; the spleen -- Pancreatitis -- Appendicitis -- Colorectal polyps and carcinoma -- Chronic inflammatory disorders of the bowel -- Disorders of large bowel motility, structure and perfusion -- Anal and perianal disorders -- Thoracic surgery -- Hernias and other groin problems -- Disorders of the male genitalia -- Symptoms, signs and investigation of urinary tract disorders -- Disorders of the prostate -- Tumours of the kidney and urinary tract -- Stone disease of the urinary tract -- Urinary tract infections -- Congenital disorders and diseases secondarily involving the urinary tract -- Pathophysiology, clinical features and diagnosis of vascular disease affecting the limbs -- Managing lower limb arterial insufficiency, the diabetic foot and major amputations -- Aneurysms and other peripheral arterial disorders -- Venous disorders of the lower limb -- Cardiac surgery -- Disorders of the breast -- Disorders of the skin -- Lumps in the head and neck and salivary calculi -- Disorders of the mouth -- Disorders of the thyroid and parathyroid glands -- Acute surgical problems in children -- Non-acute abdominal and urological problems in children.
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  • This practical, concise guide discusses how to distinguish different types of tremor and make the diagnosis of essential tremor.℗ℓ Written in an easy-to-read format, this book summarises other conditions that may be confused with essential tremor and details all current treatment options for this condition, including medications, surgery and non-invasive alternatives. Examination techniques for patients with a tremor complaint are described, some of which may be novel to the general practitioner, and case studies full of diagnostic and examination pearls are provided.℗ℓ℗ℓ℗ℓ Essential Tremor in Clinical Practice is an updated version of Abdul Qayyum Ranaℓ́ℓs previous book, An Introduction to Essential Tremor. Busy clinicians, including internists, general and family practitioners, and geriatricians will benefit from this short yet comprehensive, clinically focussed volume.
  • Getting started in laparascopy -- Laparoscopic instrumentation -- Laparoscopic access -- Laparoscopic and robotic pelvic lymphadenectomy -- Laparoscopic renal cyst decorticadtion -- Laparoscopic simple nephrectomy -- Laparoscopic readical nephrectomy: transperitoneal approach -- Laparoscopic radical nephrectomy -- Laparoscopic partial nephrectomy -- Laparoscopic nephroureterectomy -- Laparoscopic live donor nephrectomy -- Laparoscopic and robotic pyeloplasty -- Laparoscopic adrenalectomy -- Laparoscopic retroperitoneal lymph node dissection for nonseminomatous germ cell tumors -- Laparoscopic cystectomy and urinary diversion -- Laparoscopic radical cystectomy and urinary diversion with handport assistance -- Laparoscopic and robotic-assisted laparoscopic radical prostatectomy -- Complications of laparoscopic urologic surgery -- Laparoscopic renal ablation.
  • Extensively revised and updated, the second edition of Essential Urology: A Guide to Clinical Practice provides support to primary care physicians through its review of common genitourinary problems. This edition continues to provide the primary care physician with tools to better recognize urological diseases as well as updated management strategies for these disorders. To enhance the theme of comprehensive care and family medicine, the volume is formatted according to the life cycle and the urological challenges, which may be detected and diagnosed by primary care physicians respective of the patient's stage in life, beginning with pregnancy and in utero diagnoses. Pediatric themes such as infection and voiding dysfunctions are followed by adult urological topics ranging from prostate diseases, nephrolithiasis, overactive bladder syndromes, incontinence and urological cancer screening. Three new chapters are added addressing male infertility/andrology and the growing demand for integrative and alternative medical care of urologic patients, as well as commonly encountered dermatological problems in the genital area.Essential Urology: A Guide to Clinical Practice, Second Edition is extremely comprehensive and yet, very accessible. It is authored by experts representing the spectrum of urological subspecialties, further enhancing the value of this unique work.
  • E-FAST (extended focused assessment by sonograpy for trauma) represents the basic ultrasonographic approach to any trauma patient. Identification or exclusion of free fluid and air in the abdominal and thoracic cavities plays a pivotal role in deciding the immediate diagnostic and therapeutic path. Learning E-FAST is mandatory for all acute care surgeons and all physicians involved in trauma management. The structure of the book and its practical approach will make it an easy-to-consult and quick reference tool for beginners and a useful support for more experienced professionals.
  • Applied anatomy & Surgical Approaches to the Elbow -- Lateral Elbow Pain -- Medial Elbow Pain -- Distal Humerus Fractures -- Fractures and Dislocations of the Proximal Ulna & Radial head -- Elbow Stiffness -- Elbow Instability -- The Arthritic Elbow -- Tendon Injuries -- Safety in Elbow Surgery: From Open to Arthroscopy.
  • Medical gas supply -- The anaesthetic machine -- Pollution in theatre and scavenging -- Breathing systems -- Tracheal and tracheostomy tubes and airways -- Masks and oxygen delivery devices -- Laryngoscopes and tracheal intubation equipment -- Ventilators -- Humidification and filtration -- Non-invasive monitoring -- Invasive monitoring -- Pain management and regional anaesthesia -- Additional equipment used in anaesthesia and intensive care -- Electrical safety.
  • Part I. General Pathology -- Diagnostic Molecular Pathology / James Huang, Sharie B. Parks and Richard D. Press -- Human Genetic Disorders / Teresa M. Kruisselbrink, Noralane M. Lindor and John F. O'Brien -- Forensic Pathology / Jeffrey J. Barnard and Frank P. Miller -- Diagnostic Electron Microscopy / Moo-Nahm Yum and Michael P. Goheen -- Microbiology for the Surgical Pathologist / Deborah E. Blue-Hnidy and Stephen D. Allen -- Transplantation Pathology / Oscar W. Cummings -- Cytopathology / Fadi W. Abdul-Karim and Claire W. Michael -- Part II. Organ Systems -- Neuropathology / Arie Perry and Bernd W. Scheithauer -- Lymph Node / Ellen D. Remstein and Paul J. Kurtin -- Spleen / Dennis P. O'Malley and Attilio Orazi -- Bone Marrow / Dennis P. O'Malley -- Neoplasms of the Skin and Immunodermatology / Daniel P. Vandersteen and Melanie K. Triffet-Treviño -- Non-Neoplastic Skin Diseases / Steven D. Billings and Antoinette F. Hood -- Endocrine Pathology / J. Aidan Carney -- Bone and Joints / Jasvir S. Khurana and Madalina Tuluc -- Soft Tissue Tumors / Alessandra F. Nascimento, David Schembri-Wismayer and Antonio G. Nascimento -- Tumors of the Salivary Glands / Adel K. El-Naggar and John G. Batsakis -- Head and Neck / John D. Henley and Don-John Summerlin -- Eye and Ocular Adnexa / Jose M. Bonnin -- Mediastinum and Thymus / Chung-Che Jeff Chang, Gordon G. Zeng and Joseph F. Tomashefski -- Cardiovascular Pathology / Eric A. Pfeifer and Liang Cheng -- Lung / Carol F. Farver, Andrea V. Arrossi and Henry D. Tazelaar -- Breast / Eoghan E. Mooney and Fattaneh A. Tavassoli -- Vulva and Vagina / Wenxin Zheng -- Uterus and Fallopian Tube / Maritza Martel and Fattaneh A. Tavassoli -- Ovary and Peritoneum / Kevin J. Wu and Gary L. Keeney -- Placenta and Gestational Trophoblastic Disease / Raymond W. Redline -- Non-Neoplastic Renal Diseases / Donna J. Lager -- Tumors of the Kidney / Gregory T. MacLennan, Liang Cheng and David G. Bostwick -- Urinary Bladder / Liang Cheng, Antonio Lopez-Beltran and David G. Bostwick -- Prostate / David G. Bostwick and Liang Cheng -- Testis and Testicular Adnexa / Kenneth A. Iczkowski -- Penis / Gustavo Ayala and Antonio L. Cubilla -- Esophagus and Stomach / Elias A. Castilla and John R. Goldblum -- Small Intestine, Appendix, Colorectum, and Anus / Shuan C. Li -- Pancreas / N. Volkan Adsay and Olca Basturk -- Non-Neoplastic Hepatobiliary Disease / Romil Saxena, Hagen Blaszyk and Kenneth P. Batts -- Neoplasms of the Liver and Biliary System / Romil Saxena, Hagen Blaszyk and Kenneth P. Batts.
  • Part 1. General Pathology -- Cytopathology / Fadi W. Abdul-Karim, Jennifer Brainard and Claire W. Michael -- Immunohistochemical Diagnosis in Surgical Pathology / Nancy Klipfel, Raul Simental-Pizarro and Clive R. Taylor -- Tumors of Unknown Primary / Nancy Klipfel, Raul Simental-Pizarro and Clive R. Taylor -- Diagnostic Electron Microscopy / Jean L. Olson -- Transplantation Pathology / Oscar W. Cummings -- Microbiology for the Surgical Pathologist / Deborah E. Blue and Stephen D. Allen -- Forensic Pathology / Frank P. Miller and Jeffrey J. Barnard -- Autopsy / Dean Hawley -- Biomedical Informatics for Anatomic Pathology / Waqas Amin, Uma Chandran, Anil V. Parwani and Michael J. Becich -- Quality Assurance and Regulations for Anatomic Pathology / Maxwell L. Smith and Stephen S. Raab -- Molecular Diagnostic Pathology / James Huang and Richard D. Press -- Molecular Pathology of Solid Tumors / Franklin R. Moore and Richard D. Press -- Human Genetic Disorders / Teresa M. Kruisselbrink, Noralane M. Lindor, Elyse B. Mitchell, Brittany C. Thomas and Cassandra K. Runke, et al. -- Part 2. Organ Systems -- Neuropathology / Eyas M. Hattab, Matthew C. Hagen, Bernd W. Scheithauer and Arie Perry -- Lymph Node / Ellen D. McPhail and Paul J. Kurtin -- Spleen / Dennis P. O'Malley and Attilio Orazi -- Bone Marrow / Dennis P. O'Malley -- Neoplasms of the Skin and Immunodermatology / Daniel P. Vandersteen, Melanie Triffet-Treviño and Chris H. Jokinen -- Nonneoplastic Skin Diseases / Steven D. Billings and Antoinette F. Hood -- Endocrine Pathology / Lori A. Erickson -- Bone and Joints / Jasvir S. Khurana and Guldeep Uppal -- Soft Tissue Tumors / Leona A. Doyle and Alessandra F. Nascimento -- Tumor of the Salivary Glands / Diana M. Bell and Adel K. El-Naggar -- Head and Neck / John D. Henley and Don-John Summerlin -- Eye and Ocular Adnexae / Jose M. Bonnin -- Mediastinum and Thymus / Chung-Che (Jeff) Chang, Munir Shahjahan and Joseph F. Tomashefski -- Cardiovascular Pathology / Eric A. Pfeifer -- Lung and Pleura / Carol F. Farver and Andrea V. Arrossi -- Breast / Mohiedean Ghofrani and Fattaneh A. Tavassoli -- Vulva and Vagina / Sharon X. Liang and Wenxin Zheng -- Uterus and Fallopian Tube / Maritza Martel and Fattaneh A. Tavassoli -- Ovary and Peritoneum / Robert E. Emerson -- Placenta and Gestational Trophoblastic Disease / Raymond W. Redline -- Nonneoplastic Renal Diseases / Geoffrey A. Talmon and Donna J. Lager -- Tumors of the Kidney / Gregory T. MacLennan and Liang Cheng -- Urinary Bladder / Liang Cheng, Antonio Lopez-Beltran and David G. Bostwick -- Renal Pelvis, Ureter, and Urethra / Antonio Lopez-Beltran, Sean R. Williamson and Liang Cheng -- Prostate / David G. Bostwick and Liang Cheng -- Testis and Testicular Adnexa / Kenneth A. Iczkowski and Thomas M. Ulbright -- The Penis / Alcides Chaux, Gustavo Ayala and Antonio L. Cubilla -- Esophagus and Stomach / Thomas P. Plesec and John R. Goldblum -- Small Intestine, Appendix, Colorectum, and Anus / Stephen C. Lawhorn and Shuan C. Li -- Pancreas / Olca Basturk and N. Volkan Adsay -- Nonneoplastic Hepatobiliary Disease / Romil Saxena -- Neoplasms of the Liver and Biliary System / Romil Saxena.
  • Atrial fibrillation (AF) affects an estimated 1?2% of the population and is the most common cause of sustained cardiac arrhythmia. Critically, the number of patients developing AF is expected to double in the next five decades, leading to increased incidence of stroke, heart failure and other serious thromboembolic events. Essentials of Atrial Fibrillation is a timely investigation of current pharmaceutical trends, clinical guidelines, novel treatments, and ongoing pipeline developments, including ground-breaking advances in the use of novel oral anticoagulants.
  • Essentials of autopsy practice v. 3, 2006.
    v. 1. No individual title -- v. 2. Recent advances, topics, and developments -- v. 3. Current methods and modern trends (2006).
  • This book covers new and exciting topics which have emerged in the area of autopsy recently, including the three different post-mortem CT-angiography systems currently available to practitioners in this field; a highly topical chapter on the role of genetic abnormalities in the handling of drugs within the body and how this can affect the interpretation of toxicological results in relation to how the drug may have caused or contributed to death; an update on the current classification and considerations related to deaths due to hanging; a review of injuries and fatalities caused by animals including post-mortem scavenging; an authoritative review of poisons and toxins from water and the life that inhabits it; and recent advances in knowledge in the use of entomology as an investigative tool as well as knowledge related to colonisation of cadavers by insects, animals and birds. Essentials of Autopsy Practice: Advances, Updates and Emerging Technologies is a multi-subject book, aimed at different grades of practitioners, from different practice areas, covering topics that are currently discussed and anticipated to be discussed in the field of autopsy practice over the next few years.
  • Postmorten toxicological redistribution -- Examination of fractures at autopsy -- The relationship of body weight and sudden death -- Fatal sexual abuse in childhood -- Elder abuse and gerontocide -- Air crash investigation for histopathologists -- Bioterrorism -- The chronological dating of injury.
  • This title presents essential clinical knowledge in cardiac anesthesia in a practical, user-friendly format. Provides the key cardiac anesthesia information you need to know by authorities you trust. Uses a concise, user-friendly format that helps you locate the answers you need quickly. Features key points boxes in each chapter to help you quickly access the most crucial information. Includes annotated references that guide you to the most practical additional resources. Features a portable size and clinical emphasis that facilitates and enhances bedside patient care. Contains the authoritative guidance of larger reference books without the expense.
  • v. 2, 2009 Springer
    v. 3, 2009 Springer
    Volume 1. Foundations of Chinese Medicine -- Volume 2. Clinical Fundamentals in Chinese Medicine -- Volume 3. Essentials of the Clinical Specialties in Chinese Medicine.
  • The general history and physical exam -- The abdominal exam -- The breast exam -- The cardiovascular exam -- The geriatric exam -- The gynecological exam -- The head and neck exam -- The lymphatic system and lymph node exam -- The musculoskeletal exam -- The neurological exam -- The obstetric exam -- The ophthalmological exam -- The pediatric exam -- The peripheral vascular exam -- The psychiatric exam -- The peripheral vascular exam -- The psychiatric exam -- The respiratory exam -- The urological exam -- The essentials of clinical pharmacology and toxicology -- The essentials of dermatology -- The essentials of emergency medicine -- The essentials of endocrinology -- The essentials of fluids, electrolytes, and acid/base disturbances -- The eseentials of general surgery -- The essentials of infectious diseases -- The essentials of medical imaging -- The essentials of oncology -- The essentials of pain management and pre-operative assessment -- Appendix 1. Concepts in evidence-informed medical practice -- Appendix 2. Commonly used drugs -- Appendix 3. Common laboratory values -- Index.
  • Clinical implications of the aging process -- The geriatric patient : demography, epidemiology, and health services utilization -- Evaluating the geriatric patient -- Chronic disease management -- Prevention -- Delirium and dementia -- Diagnosis and management of depression -- Incontinence -- Falls -- Immobility -- Cardiovascular disorders -- Decreased vitality -- Sensory impairment -- Drug therapy -- Health services -- Nursing home care -- Ethical issues in the care of older persons -- Palliative care.
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    Basic components: structure and function -- Infection -- Immunodeficiency -- Anaphylaxis and allergy -- Autoimmunity -- Lymphoproliferative disorders -- Immune manipulation -- Transplantation -- Kidney diseases -- Joints and muscles -- Skin diseases -- Eye diseases -- Chest diseases -- Gastrointestinal and liver diseases -- Endocrinology and diabetes -- Haematological diseases -- Neuroimmunology -- Pregnancy -- Techniques in clinical immunology.
  • "The objective of this book is to serve as a practical educational resource for clinical magnetic resonance imaging. The bulk of the text is organized along anatomic lines and discusses disease entities commonly encountered in clinical practice. The focus is illustrating and describing the MR appearances of the most commonly imaged disease entities, covering briefly in each area important points relative to imaging techniques then discussing in depth, the clinical MR interpretation. The breadth of clinical MRI is explored. For each subtopic within an anatomic region, clinical cases serve as the backbone for discussion, the most common pathologies affecting each anatomic region being illustrated. The final chapters discuss specifically contrast media and contrast enhanced MRA, two topics worthy of further description due to their present clinical importance. When relevant to diagnosis or essential for understanding, MR physics is discussed, however the reader is referred separately to Runge et al, The Physics of Clinical MR Taught Through Images 2nd Edition (New York: Thieme; 2009) for further elaboration. It is the goal that upon completing this text, the reader will have an appreciation for the complexity, utility, and versatility of MR in clinical imaging and will possess the knowledge essential for interpretation of basic clinical MR examinations"--Provided by publisher.
  • "Clinical Mycology" offers a comprehensive review of this discipline. Organized by types of fungi, this volume covers microbiologic, epidemiologic and demographic aspects of fungal infections as well as diagnostic, clinical, therapeutic, and preventive approaches. Special patient populations are also detailed.
  • In its extensively revised and updated Second Edition, this book provides a solid foundation for readers interested in clinical research. Discussion encompasses genetic, pharmacoepidemiologic and implementation research. All chapters have been updated with new information and many new tables have been added to elucidate key points. The book now offers discussion on how to handle missing data when analyzing results, and coverage of Adaptive Designs and Effectiveness Designs and new sections on Comparative Effectiveness Research and Pragmatic Trials. Chapter 6 includes new material on Phase 0 Trials, expanded coverage of Futility Trials, a discussion of Medical Device approval, Off Label Drug use and the role of the FDA in regulating advertising. Additional new information includes the role of pill color and shape in association with the placebo effect and an examination of issues surrounding minority recruitment. The final chapter offers a new section on manuscript preparation along with a discussion of various guidelines being adopted by journals: CONSORT, STROBE, PRISMA, MOOSE and others; and coverage of Conflicts of Interest, Authorship, Coercive Citation, and Disclosures in Industry-Related Associations. Building on the strengths of its predecessor in its comprehensive approach and authoritative advice, the new edition offers more of what has made this book a popular, trusted resource for students and working researchers alike.
  • I. pt. I. Clinical Research: Definitions, "Anatomy and Physiology," and the Quest for "Universal Truth" / Stephen P. Glasser, p. 3-11 -- Introduction to Clinical Research and Study Designs / Stephen P. Glasser, p. 13-27 -- Clinical Trials / Stephen P. Glasser, p. 29-62 -- Alternative Interventional Study Designs / Stephen P. Glasser, p. 63-71 -- Postmarketing Research / Stephen P. Glasser, Elizabeth Delzell and Maribel Salas, p. 73-91 -- The United States Federal Drug Administration (FDA) and Clinical Research / Stephen P. Glasser, Carol M. Ashton and Nelda P. Wray, p. 73-110 -- The Placebo and Nocebo Effect / Stephen P. Glasser and William Frishman, p. 111-140 -- Recruitment and Retention / Stephen P. Glasser, p. 141-149 -- Data Safety and Monitoring Boards (DSMBs) / Stephen P. Glasser and O. Dale Williams, p. 151-158 -- Meta-Analysis / Stephen P. Glasser and Sue Duval, p. 159-177 -- II. pt. II. -- Research Methods for Genetic Studies / Sadeep Shrestha and Donna K. Arnett, p. 181-199 -- Research Methods for Pharmacoepidemiology Studies / Maribel Salas and Bruno Stricker, p. 201-216 -- Implementation Research: Beyond the Traditional Randomized Controlled Trial / Amanda H. Salanitro, Carlos A. Estrada and Jeroan J. Allison, p. 217-244 -- Research Methodology for Studies of Diagnostic Tests / Stephen P. Glasser, p. 245-257 -- III. pt. III. Statistical Power and Sample Size: Some Fundamentals for Clinician Researchers / J. Michael Oakes, p. 261-278 -- Association, Cause, and Correlation / Stephen P. Glasser and Gary Cutter, p. 279-294 -- Bias, Confounding, and Effect Modification / Stephen P. Glasser , p. 295-302 -- It's All About Uncertainty / Stephen P. Glasser and George Howard, p. 303-316 -- Grant Writing / Donna K. Arnett and Stephen P. Glasser, p. 317-325 -- IV. pt. IV. The Media and Clinical Research / Stephen P. Glasser, p. 329-333 -- Mentoring and Advising / Stephen P. Glasser and Edward W. Hook, p. 335-340 -- Presentation Skills: How to Present Research Results / Stephen P. Glasser, p. 341-349.
  • An overview of creatine metabolism / Jeff S. Volek, Kevin D. Ballard, and Cassandra E. Forsythe -- Creatine supplementation in strength-power sports / Darryn S. Willoughby -- Creatine supplementation in endurance sports / Joel P. Cramer -- Creatine supplementation and woman athletes / Joan Eckerson -- Creatine consumption and health / Jacques R. Poortmans and Marc Francaux -- Clinical application / Joseph Weir -- Creatine overview : facts, fallacies, and future / Mike Greenwood.
  • The Normal Breast -- Specimen Processing -- Fibrocystic Change and Duct Ectasia -- Adenosis -- Intraductal Proliferative Lesions -- Intraductal Papillary Neoplasms -- Lobular Intraepithelial Neoplasia (LIN) -- Infiltrating Ductal Carcinoma (NOS Type) -- Invasive Lobular Carcinoma (ILC) -- Special Types of Breast Carcinomas -- Biphasic Tumors -- Disease of the Nipple -- Male Breast Lesions -- Mesenchymal Lesions/Tumors -- Myoepithelial Lesions/Neoplasms -- Miscellaneous Lesions -- Cytopathology of Benign and Malignant Lesions (Selected Topics) -- Immunohistochemistry (Selected Topics).
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  • "During the last two decades, new developments in functional MRI (magnetic resonance imaging) have made it possible to detect changes in the brain over time, as opposed to the "snapshot" produced by conventional MRI. Essentials of Functional MRI breaks down the technical challenges for physicians, researchers, and technologists who use functional MRI but may not be experts in the necessary math and physics. The author describes the theory and practical details of functional MRI (fMRI) methodology, including how to acquire and analyze images, and a wide range of examples demonstrate how fMRI has been used thus far. The author provides the essential information to study, understand, use, and teach the practical aspects of fMRI for those people who are most likely to extend its use into clinical practice"--Provided by publisher.
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    Perioperative evaluation and management of surgical patients / Virginia A. Eddy ... [et al.] -- Fluids, electrolytes, and acid/base balance / David Antonenko ... [et al.] -- Nutrition / Gail Cresci ... [et al.] -- Surgical bleeding : bleeding disorders, hypercoagulable states, and replacement therapy in the surgical patient / Hollis W. Merrick III ... [et al.] -- Shock : cell metabolic failure in critical illness / Kenneth W. Burchard ... [et al.] -- Surgical critical care / Samuel A. Tisherman ... [et al.] -- Wounds and wound healing / Glenn E. Talboy Jr., Annesley W. Copeland, Gregory J. Gallina -- Surgical infections / R. Neal Garrison ... [et al.] -- Trauma / Matthew O. Dolich ... [et al.] -- Burns / Jeffrey R. Saffle ... [et al.] -- Abdominal wall, including hernia / Leigh Neumayer ... [et al.] -- Esophagus / Carlos M. Li, James A. McCoy, and Hwei-Kang Hsu -- Stomach and duodenum / John T. Paige ... [et al.] -- Small intestine and appendix / John D. Mellinger ... [et al.] -- Colon, rectum, and anus / Merril T. Dayton -- Biliary tract / O. Joe Hines ... [et al.] -- Pancreas / Steven B. Goldin ... [et al.] -- Liver / William C. Chapman ... [et al.] -- Breast / Gary L. Dunnington .. [et al.] -- Surgical endocrinology / Nicholas P.W. Coe ... [et al.] -- Spleen and lymph nodes / James C. Hebert ... [et al.] -- Diseases of the vascular system / James F. McKinsey ... [et al.] -- Transplantation / Hilary Sanfey ... [et al.] -- Surgical oncology : malignant diseases of the skin and soft tissue / D. Scott Lind ... [et al.].
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  • The foundations of genomic and personalized medicine -- Section 1. Basics -- Organization, variation and expression of the human genome -- DNA sequencing for the detection of human genome variation -- Genome-wide association studies and genotyping technologies -- Copy number variation and human health -- DNA methylation analysis: providing new insight into human disease -- DNA microarrays in biological discovery and patient care -- Proteomics: the deciphering of the functional genome -- Comprehensive metabolic analysis for understanding of disease -- Section 2. Informatics -- Bioinformatic and computational analysis for genomic medicine -- Systems biology and systems medicine -- Electronic medical records in genomic medicine practice and research -- Online health information retrieval by consumers -- Section 3. Translational -- Translational genomics: from discovery to clinical practice -- Pharmacogenetics and pharmacogenomics -- Clinical implementation of translational genomics -- The role of genomics in enabling prospective health care -- Genome policy considerations for genomic medicine -- Federal regulation of genomic medicine -- Economic issues and genomic medicine -- Public health genomics. Section 4. Clinical (cardiology) -- The genomics of hypertension -- Lipoprotein disorders -- Genomics of myocardial infarction -- Acute coronary syndromes -- Heart failure in the era of genomic medicine -- Genomic assessment of cardiac transplant rejection -- Genetics and genomics of hypertrophic cardiomyopathy -- Genetics and genomics of arrhythmias -- Genetics and genomics in the management of hemostasis and thrombosis -- Genomics of congenital heart disease -- Section 5. Clinical (oncology) -- Genomics in the management of lymphomas -- Genomics in leukemias -- Genomics in the diagnosis and management of lung cancer -- Genomics in the diagnosis and management of breast cancer -- Colorectal cancer -- Genomic evaluation and management of prostate cancer -- Genomic assessment of ovarian cancer -- Genomic evaluation of pancreatic neoplasms -- Genomic evaluation of head and neck cancer -- Genomic evaluation of brain tumors and gliomas -- Targeted therapies for cancer. Section 6. Clinical (inflammatory disease) -- Genomics in the evaluation and management of rheumatoid arthritis -- Genomic evaluation of multiple sclerosis -- Genomic assessment of inflammatory bowel disease -- Asthma genomics -- Genomics in the evaluation and management of chronic obstructive pulmonary disease -- Genetics and genomics of interstitial lung disease -- Peptic ulcer disease -- Section 7. Clinical (metabolic disease) -- Genomics in pathogenesis of cirrhosis -- Genomic medicine and obesity -- Diabetes -- Section 8. Clinical (neurological disease) -- Genetics and genomics of dementia -- Genetics and genomics of Parkinson's disease -- Genomic considerations in ophthalmology -- Genomics in the diagnosis and management of depression -- Section 9. Clinical (infectious disease) -- Genomic approaches to the host response to pathogens -- Host genomics and bacterial infections -- Genomics in the evaluation and management of sepsis -- Genomics and the management of hepatitis.
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    Why learn methods in infectious disease epidemiology? -- Why study methods? -- Descriptive infectious disease epidemiology -- Outbreak investigations -- Rates and measures -- Laying the foundation: how to conduct a study -- Experimental designs as a foundation for observational studies -- Cohort studies -- Case-control and cross-sectional studies -- Interpretation of epidemiologic data -- Threats to internal and external validity of concern in the study of infectious disease epidemiology -- Surveillance of infectious diseases -- Program evaluation in the infectious disease setting.
  • Basic Research/Mechanisms -- A Historical Overview and Concepts of Mesenchymal Stem Cells / Shihua Wang, Robert Chunhua Zhao -- Biology of MSCs Isolated from Different Tissues / Simone Pacini -- Secretome of Mesenchymal Stem Cells / Yuan Xiao ... [et al.] -- Immunomodulatory Properties of Mesenchymal Stem Cells and Related Applications / Lianming Liao, Robert Chunhua Zhao -- Mesenchymal Stem Cell Homing to Injured Tissues / Yaojiong Wu, Robert Chunhua Zhao -- Major Signaling Pathways Regulating the Proliferation and Differentiation of Mesenchymal Stem Cells / Joseph D. Lamplot ... [et al.] -- MicroRNAs in Mesenchymal Stem Cells / Mohammad T. Elnakish, Ibrahim A. Alhaider, Mahmood Khan -- Genetic Modification of MSCs for Pharmacological Screening / Jie Qin, Martin Zenke -- Control of Mesenchymal Stem Cells with Biomaterials / Sandeep M. Nalluri, Michael J. Hill, Debanjan Sarkar -- Clinical Translation -- Mesenchymal Stem Cells for Cardiovascular Disease / Wei Wu, Shuyang Zhang -- Mesenchymal Stem Cells as Therapy for Graft Versus Host Disease: What Have We Learned? / Partow Kebriaei ... [et al.] -- Mesenchymal Stem Cells for Liver Disease / Feng-chun Zhang -- Mesenchymal Stem Cells for Bone Repair / Hongwei Ouyang, Xiaohui Zou, Boon Chin Heng, Weiliang Shen -- Mesenchymal Stem Cells for Diabetes and Related Complications / Vladislav Volarevic, Majlinda Lako, Miodrag Stojkovic -- Mesenchymal Stromal Cell (MSC) Therapy for Crohn's Disease / Jignesh Dalal -- The Summary of Stroke and Its Stem Cell Therapy / Renzhi Wang ... [et al.] -- Mesenchymal Stem Cell Transplantation for Systemic Lupus Erythematosus / Lingyun Sun -- International Regulations and Guidelines Governing Stem Cell Based Products -- Considerations of Quality Control Issues for the Mesenchymal Stem Cells-Based Medicinal Products / Bao-Zhu Yuan ... [et al.] -- Regulations/Ethical Guidelines on Human Adult/Mesenchymal Stem Cell Clinical Trial and Clinical Translation / Xiaomei Zhai, Renzong Qiu.
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  • This title in the Essentials of Anesthesia and Critical Care series presents core clinical neuroanesthesia and neurointesive care knowledge in a practical, user-friendly format. Provides the key neuroanesthesia and neurointensive care information you need from authorities you trust. Uses a concise, user-friendly format to help you locate answers quickly. Features key points boxes in each chapter to help you quickly access the most crucial information. Includes annotated references that guide you to the most relevant additional resources. Features a compact size and clinical emphasis that facilitates and enhances bedside patient care.
  • 2012 ClinicalKey
    Radioactivity, radionuclides, and radiopharmaceuticals -- Instrumentation and quality control -- Central nervous system -- Thyroid, parathyroid, and salivary glands -- Cardiovascular system -- Respiratory system -- Gastrointestinal tract -- Skeletal system -- Genitourinary system and adrenal glands -- Non-PET neoplasm imaging and radioimmunotherapy -- ¹⁸F-FDG PET/CT neoplasm imaging -- Inflammation and infection imaging -- Authorized user and radioisotope safety issues -- Self-evaluation. Unknown case sets -- Answers to unknown case sets -- Appendix A: Characteristics of radionuclides for imaging and therapy -- Appendix B-1: Radioactivity conversion table for International System (SI) Units (Becquerels to Curies) -- Appendix B-2: Radioactivity conversion table for International System (SI) Units (Curies to Becquerels) -- Appendix C-1: Technetium-99m decay and generation tables -- Appendix C-2: Other radionuclide decay tables -- Appendix D: Injection techniques and pediatric dosages -- Appendix E-1: Sample techniques for nuclear imaging -- Appendix E-2: Abnormal radio pharmaceutical distribution as a result of medications and other extrinsic factors -- Appendix F: Nonradioactive pharmaceuticals in nuclear medicine -- Appendix G: Pregnancy and breastfeeding -- Appendix H-1: General considerations for hospitalized patients receiving radionuclide therapy -- Appendix H-2: Special considerations and requirements for iodine-131 therapy -- Appendix I: Emergency procedures for spills of radioactive materials.
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  • This book will aid surgeons in mastering the essential skills necessary in the ever expanding field of cardiac surgery. As well as presenting basic surgical principles, emphasis throughout the book has been placed on providing essential tips to make every cardiac surgical operation easy, reproducible and safe to perform, and tricks to enable surgeons to manage the difficult situations they are likely to encounter and prevent serious complications. Essentials of Operative Cardiac Surgery is an indispensable text for trainees and established consultants in adult cardiac surgery.
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    Ch. 1 Ocular anatomy, physiology, and embryology -- Ch. 2 Basic optics -- Ch. 3 Ocular pharmacology -- Ch. 4 The eye exam -- Ch. 5 Neuro-ophthalmology -- Ch. 6 Pediatric ophthalmology and strabismus -- Ch. 7 Orbit -- Ch. 8 Lids and adnexa -- Ch. 9 Conjunctiva -- Ch. 10 Sclera -- Ch. 11 Cornea -- Ch. 12 Anterior chamber -- Ch. 13 Glaucoma -- Ch. 14 Iris -- Ch. 15 Lens -- Ch. 16 Vitreous -- Ch. 17 Retina -- App. Differential diagnosis of common ocular symptoms.
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  • This concise third edition offers hands-on guidance for identifying and treating the most commonly seen orthopedic problems in children and adults. Convenient as a study source for medical students, its many photographs and illustrations will also serve as a useful clinical reference for young surgeons, residents, nurses, and physician assistants. Each of the many topics is covered in depth and is designed to educate medical students and steer them towards formulating excellent diagnoses and treatment plans. As a further aid, multiple-choice questions are included at the end of each chapter.
  • 2011 ClinicalKey
    Section I. Basic Considerations -- Section II. Clinical Evaluation and Diagnostic Examinations -- Section III. Pharmacology and Pharmacologic Modalities -- Section IV. Therapeutic Interventions -- Section V. Perioperative Pain Management -- Section VI. Chronic Pain Syndromes -- Section VII. Interventional Techniques for Pain Management -- Section VIII. Cancer Pain -- Section IX. Nerve Blockade.
  • 1. Introduction and Education / Angèle Ryan and Jack M. Berger -- 2. Multidisciplinary Approach and Coordination of Care / Sukanya Mitra and Nalini Vadivelu -- 3. Psychological Distress and Psychiatric Comorbidities in Palliative Care / Raphael J. Leo and Maria Theresa Mariano-- 4. Hospice for the Terminally Ill and End-of-Life Care / Jamie Capasso, Robert Byron Kim, and Danielle Perret -- 5. Communication in Palliative Care / Dominique Anwar, Sean Ransom, and Roy S. Weiner -- 6. Guidance with Complex Treatment Choices / Sukanya Mitra and Nalini Vadivelu -- 7. Symptom Management / Angèle Ryan -- 8. Nutrition in Palliative Care / M. Khurram Ghori and Susan Dabu-Bondoc -- 9. Nursing Perspective and Considerations / Ena M. Williams and Tong Ying Ge -- 10. Physical and Occupational Therapy in Palliative Care / Kais Alsharif and Justin Hata -- 11. Social Work in Palliative Care / Janet Lucas, Bill Mejia, and Anne Riffenburgh -- 12. The Healthcare System: More Questions than Answers / Jackie D.D. Carter -- 13. Vascular Access: Ostomies and Drains Care in Palliative Medicine / Patricia L. Devaney -- 14. Drug Formulary / Angèle Ryan -- 15. Interventional Radiology in Palliative Care / Oliver Hulson, Neal Larkman, and S. Kunnumpurath -- 16. Stroke, Epilepsy, and Neurological Diseases / María Gudín -- 17. Interventional Techniques in Palliative Care / Rinoo V. Shah, Alan David Kaye, Christopher K. Merritt, and Lien B. Tran -- 18. Headache in Palliative Care / Nicholas Connolly, Matthew Peña, and Tara M. Sheridan -- 19. Endoscopic Therapies for Palliation of Gastrointestinal Malignancies / Henry C. Ho and Uzma D. Siddiqui -- 20. The Role of Palliative Care in Cardiothoracic Surgery / Amit Banerjee -- 21. Management of Advanced Heart Failure Patients / Dominique Anwar and Asif Anwar -- 22. Palliative Care in Cardiac Electrophysiology / Eric Grubman -- 23. Palliation in Respiratory Disease / David R. Meek, Martin D. Knolle, and Thomas B. Pulimood -- 24. Palliative Care in Critical Care Units / Rita Agarwala, Ben Singer, and Sreekumar Kunnumpurath -- 25. Pediatric Palliative Care / Shu-Ming Wang, Paul B. Yost, and Leonard Sender -- 26. New Pain Management Vistas in Palliative Care / Christopher K. Merritt, Lien B. Tran, Rinoo V. Shah, and Alan David Kaye -- 27. Ethics in Palliative and End-of-Life Care / Jack M. Berger -- 28. Physician Coding, Billing, and Reimbursement for Palliative Care / Rene R. Rigal.
  • Introduction -- Fistula First, K/DOQI and Documentation -- The Dialysis Outcomes and Practice Pattern Study (DOPPS): Lessons for Interventionalists -- Controversies in Vascular Access Monitoring and Surveillance -- Clinical Relevance of Vascular Access Monitoring and Surveillance -- Molecular Mechanisms of Hemodialysis Graft Failure -- The Vascular Access Coordinator -- The Procedure Room, Equipment and Radiation Safety -- Patient Considerations and Preparation -- Patient Monitoring, Sedation and Post-Procedure Care -- Sterile Technique -- Contrast Agents -- Dialysis Catheters -- Dialysis Grafts Versus Fistulas -- Commonality of Interventions in AV Accesses -- Interventions in Dialysis Grafts -- Interventions in Dialysis Fistulas -- The Immature or Failure to Mature Fistula -- Cephalic Arch Stenosis -- Central Venous Interventions -- Hemodialysis Access Interventions: An Asian Perspective -- Pediatric Hemodialysis Interventions -- Puncture Site Management -- No Remaining Venous Access -- Radiologic Peritoneal Dialysis Catheter Insertion and Troubleshooting -- Complications and Possible Solutions -- On-Label, Off-Label, Misconceptions and Devices that Do not Work -- Publications of Hemodialysis Interventions: What Is Relevant? -- Interesting Cases.
  • 2014 ClinicalKey
  • "The second edition of a bestseller, this new edition has been totally revised and updated with 10 new chapters and many new contributors. It provides essential information in a convenient and easily accessible outline format and is small enough to fit in a lab coat pocket, while still providing comprehensive coverage of the essential topics in aesthetic and reconstructive surgery. The book does not skimp on coverage of aesthetic surgery, face lift, neck lift, fillers, and breast augmentation are given equal time with reconstructive topics such as wound healing, flaps, and microsurgery"--Provided by publisher.
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  • "Radiology receives little attention in most medical school curricula except perhaps as an elective. The classic gross anatomy laboratory is dead, and most health care providers encounter human internal anatomy and function through radiology. This text is not meant to make you into a radiologist or to be just a text for a radiology medical student elective. It is intended to be a text that will provide a basis for radiologic anatomy, imaging fundamentals, and common clinical problems and to be a book that you will keep and use in your future practice. Since the first edition, this text has been widely used by medical students, nurse practitioners, physician assistants, primary care physicians, and first-year radiology residents"--Preface.
  • Part I. General Principles of Regional Anesthesia Practice -- 1. General Considerations for Regional Anesthesia Practice / Edward R. Mariano and Karley J. Mariano -- 2. Monitoring for Regional Anesthesia / Jeff Gadsden -- 3. Regional Anesthesia in the Community Practice Setting / Joseph Marino and Brian E. Harrington -- Part II. Basic Science and Clinical Practice -- 4. The Anatomy of Pain / Harry J. Gould III and Alan David Kaye -- 5. Practical Pharmacology in Regional Anesthesia / Jose A. Aguirre, Gina Votta-Velis, and Alain Borgeat -- 6. Anticoagulation and Regional Anesthesia Concerns / Rinoo Shah, Alan David Kaye, Adam Kaye, and Jeffrey Y. Tsai -- Part III. Equipment for Regional Anesthesia -- 7. Equipment and Clinical Practice: Aids to Localization of Peripheral Nerves / Beverly Pearce-Smith and Johnny K. Lee -- 8. Principles of Sonography / Paul E. Bigeleisen and Steven Orebaugh -- 9. Ultrasound-Guided Peripheral Nerve Blockade / David M. Polaner and Alan Bielsky -- 10. Sonopathology / Jonathan T. Weed and Brian D. Sites -- Part IV. Techniques for Regional Anesthesia -- 11. Neuraxial Blockade: Subarachnoid Anesthesia / Maria Teresa Gudin, Ramón López, Jesus Estrada, and Esperanza Ortigosa -- 12. Neuraxial Blockade: Epidural Anesthesia / Sreekumar Kunnumpurath, S. Ramessur, A. Fendius, and Nalini Vadivelu -- 13. Upper Extremity Nerve Blocks / De Q.H. Tran, Shubada Dugani, and Juan Francisco Asenjo -- 14. Peripheral Nerve Blocks for the Lower Extremity / Sylvia Wilson and Anna Uskova -- 15. Regional Anesthetic Techniques for Foot Surgery / Rick Chien-An Chen and Peter A. Blume -- 16. Regional Anesthesia of Thorax and Abdomen / Rita Merman and Vlad Shick -- 17. Head and Neck: Scalp, Ophthalmic, and Cervical Blocks / Desiree Persaud and Sébastian Garneau -- 18. Local Anesthesia of the Masticatory Region / Henry A. Gremillion, Christopher J. Spencer, and Alex D. Ehrlich -- 19. Topical and Regional Anesthesia of the Airway / Ryan P. Ellender, Paul L. Samm, and Richard H. Whitworth, Jr. -- 20. Selective Regional Anesthesia Options in Surgical Subspecialties / Henry Liu, Charles James Fox, Michael J. Yarborough, and Alan David Kaye -- 21. Regional Anesthesia for Chronic Disease States / Siamak Rahman and Parisa Partownavid -- 22. Intravenous Regional Anesthesia / Lindsey Vokach-Brodsky -- 23. Regional Anesthesia and Trauma / Daniela Elena Francesca Ghisi, Andrea Fanelli, and Carl Rest -- 24. Postoperative Pain Management / Ralf E. Gebhard and Andres Missair -- 25. Sympathetic Blockade / Rafael Justiz, Audra Day, and Miles Day -- Part V. Special Populations -- 26. Regional Anesthesia for Chronic Pain / Vijay Krishnamoorthy, Ruben Koshy, Gina Votta-Velis, and Alain Borgeat -- 27. Regional Anesthetic Techniques for the Pediatric Patient / Bryan Fritz, Marlene Barnhouse, Usha Ramadhyani, and Bobby Nossaman -- 28. Obstetric Anesthesiology / Ray L. Paschall -- 29. Regional Anesthesia for Outpatient Surgery / Joshua E. Smith -- Part VI. Additional Topics -- 30. Outcome Studies and Infection Control in Regional Anesthesia / Joel Barton and Stuart A. Grant -- 31. Regional Anesthesiology Education / Jonathan C. Beathe.
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    Basic chemistry -- General prinicples of gas physics -- Microbiology, sterilization, and infection control -- Anatomy of the respiratory system -- Mechanics of ventilation -- Neurologic control of ventilation -- Oxygen and carbon dioxide transport -- Intrapulmonary shunting and deadspace -- Antomy of the cardiovascular system -- Physiology of the cardiovascular system -- Cardiac electrophysiology and ECG interpretation -- Hemodynamic monitoring -- Renal anatomy and physiology -- Fluid and electrolyte balance -- Acid-base balance and blood gas interpretation -- Anatomy and physiology of the nervous system -- Pharmacology -- Clinical assessment of the cardiopulmonary system -- Pulmonary function testing -- Obstructive pulmonary disease and general management principles -- Obstructive pulmonary disease and ventilatory management -- Restrictive lung diseases: general and ventilatory management -- ARDS, SARS, and sepsis -- Nutrition -- Intrauterine development and comparative respiratory anatomy -- Assessment and management of the newborn -- Respiratory disorders of the newborn -- Mechanical ventilation of the newborn -- Respiratory disorders of the pediatric patient -- Assisted ventilation for pediatric patients -- Pulmonary rehabilitation -- Home respiratory care and mechanical ventilation -- Gas therapy -- Oxygen, helium, and nitric oxide therapy -- Aerosol and humidity therapy -- Airway clearence techniques -- Analyzers -- Airway care -- Modes of mechanical ventilation -- Positive end-expiratory pressure -- Initiation, maintenance, and weaning from mechanical ventilation -- High frequency ventilation -- Noninvasive positive pressure ventilation -- Tracheal gas insufflation -- Prone positioning -- Liquid ventilation.
  • Also available: Print – 2007
  • Essentials of Robotic Surgery is designed to present a comprehensive and state-of-the-art approach to robotic surgery within the broad confines of general surgery. Sections address preliminary issues surgeons face when initially undertaking robotics. These areas include training, basic techniques, setup, and general troubleshooting. Subsequent chapters focus on specific disease processes and the robotic applications for those procedures. Written by experts in the field, each of these sections address patient selection, preoperative considerations, technical conduct of the most common operations, and avoiding complications. A brief review of the existing literature addressing the particular topic follows in each section. The text concludes with chapters on other robotic platforms beyond the only current FDA approved device (Intuitive Surgical) as well as future directions, including single-site, enhanced imaging, 3-D modeling, and tele-proctoring, including to and distant site surgery. Extensive illustrations and links to video make this an interactive text. Essentials of Robotic Surgery is of great value to general surgeons and associated sub-specialists, trainees including residents and fellows, fully trained surgeons looking to start a robotic surgery practice, and experienced robotic surgeons looking to expand the types of procedures that they currently perform robotically.
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  • 1. Normal sleep / James A. Rowley and M. Safwan Badr -- 2. Pharmacology of sleep / Susmita Chowdhuri -- 3. Obstructive sleep apnea: diagnosis with polysomnography and portable monitors / Chunbai Zhang, Stefanos N. Kales, and Atul Malhotra -- 4. Approach to hypersomnia / James A. Rowley -- 5. Obstructive sleep apnea: epidemiology of sleep apnea / Jessie P. Bakker, Atul Malhotra, and Sanjay R. Patel -- 6. Obstructive sleep apnea: clinical features and adverse consequences / Geraldo Lorenzi-Filho and Pedro Rodrigues Genta -- 7. Assessments of driving risk in sleep apnea / Kingman P. Strohl -- 8. Nasal continuous positive airway pressure (CNAP) treatment / Srinivas Bhadriraju and Nancy Collop -- 9. Obstructive sleep apnea: oral appliances / Peter A. Cistulli, Kate Sutherland, and Andrew S.L. Chan -- 10. Obstructive sleep apnea: surgery / Ryan J. Soose and Patrick J. Strollo -- 11. Sleep and lung disease / Charles W. Atwood, Jr. -- 12. Central sleep apnea / M. Safwan Badr -- 13. Insomnia: etiology, clinical manifestations, and morbidity / Clare E. Gargaro, Thomas Roth, and Christopher L. Drake -- 14. Management of insomnia / Luisa Bazan, Thomas Roth, and Christopher L. Drake -- 15. Circadian disorders / Brandon S. Lu, Jeff Kwon, and Phyllis C. Zee -- 16. Narcolepsy and idiopathic hypersomnia / Imran Ahmed and Michael Thorpy -- 17. Parasomnias / Hrayr Attarian -- 18. Movement disorders / Nidhi S. Undevia -- 19. Perioperative care of patients with obstructive sleep apnea syndrome / Haven R. Malish and Peter C. Gay -- 20. Sleep and critical illness / Nimesh Patel and Sairam Parthasarathy.
  • I. Principles of Spinal Cord Injury Clinical Practice. -- 1. Anatomy and Physiology of the Spinal Cord -- 2. Evaluation of the Patient with Spinal Cord Injury -- 3. Imaging of Acute Spinal Cord Trauma and Spinal Cord Injury -- 4. Pathophysiology of Spinal Cord Injury -- 5. Epidemiology of Traumatic Spinal Cord Injury -- 6. Spinal Cord Injury Classification -- 7. Spontaneous Recovery Patterns and Prognoses after Spinal Cord Injury -- 8. Management of Spinal Cord Injury in the Intensive Care Unit -- 9. Concomitant Traumatic Brain Injury and Spinal Cord Injury -- 10. Pharmacotherapy in Acute Spinal Cord Injury: Focus on Steroids -- 11. Halo Application and Closed Skeletal Reduction of Cervical Dislocations -- 12. Principles of Surgical Management of Spinal Trauma Associated with Spinal Cord Injury -- 13. Venous Thromboembolism Prophylaxis -- 14. Sexuality and Fertility after Spinal Cord Injury -- 15. Interdisciplinary Essentials in Pressure Ulcer Management -- 16. Autonomic Dysreflexia and Cardiovascular Complications of Spinal Cord Injury -- 17. Pain after Spinal Cord Injury -- 18. Essentials of Spinal Cord Injury: Psychosocial Aspects of Spinal Cord Injury -- 19. Posttraumatic Kyphotic Deformity of the Cervical Spine -- 20. Posttraumatic Syringomyelia: Pathophysiology and Management -- 21. Rehabilitation of the Individual with Spinal Cord Injury -- 22. The Management of Secondary Complications Following Spinal Cord Injury -- II. Controversies in Management. -- 23. Timing of Surgery for Acute Spinal Cord Injury: From Basic Science to Clinical Application -- 24. Hypothermia: Evidence-Based Review -- 25. Management of Cervical Facet Dislocation -- 26. Management of Acute Spinal Cord Injury in Thoracolumbar Burst Fractures Including Cauda Equina Syndrome -- 27. Management of Central Cord Syndrome -- III. Neuroprotective and Neuroregenerative Approaches. -- 28. Research in Spinal Cord Injury: Building an Effective Translational Research Program -- 29. North American Clinical Trials Network: Building a Clinical Trials Network for Spinal Cord Injury -- 30. Considerations for the Initiation and Conduct of Spinal Cord Injury Clinical Trials -- 31. Animal Models of Spinal Cord Injury -- 32. Glial Scar and Monocyte-Derived Macrophages Are Needed for Spinal Cord Repair: Timing, Location, and Level as Critical Factors -- 33. Promising Preclinical Pharmacological Approaches to Spinal Cord Injury -- 34. Cellular Transplantation in Spinal Cord Injury -- 35. Neuroregeneration Approaches -- 36. Neuroprotective Trials in Spinal Cord Injury -- 37. Approaches Using Biomaterials for Tissue Engineering -- IV. Neurophysiology and Imaging. -- 38. Electrophysiological Measures after Spinal Cord Injury -- 39. Quantitative Tests of Sensory, Motor, and Autonomic Function -- 40. Basic Neurophysiological Approaches to Probing Spinal Circuits -- 41. Neuroimaging after Spinal Cord Injury: Evaluating Injury Severity and Prognosis Using Magnetic Resonance Imaging -- 42. The Role of Neurophysiology in the Study of Recovery and Spasticity -- V. Plasticity and Recovery. -- 43. Spinal and Supraspinal Plasticity after Spinal Cord Injury -- 44. The Human Central Pattern Generator and Its Role in Spinal Cord Injury Recovery -- 45. Electrophysiological Predictors of Lower Limb Motor Recovery: The Rehabilitation Perspective -- 46. Somatosensory Function and Recovery after Spinal Cord Injury: Advanced Assessment of Segmental Sensory Function -- 47. Electrical Stimulation Following Spinal Cord Injury -- 48. Operant Conditioning of Spinal Reflexes to Improve Motor Function after Spinal Cord Injury -- 49. Functional Restoration through Robotics -- 50. Peripheral Nerve Grafts and the Repair of Axonal Circuits Following Spinal Cord Injury -- VI. Resources. -- 51. Population-Based Spinal Cord Injury Registries: Potential Impacts and Challenges -- 52. Resources to Empower and Expand the Opportunities of People with Spinal Cord Injury -- VII. Achieving Success. -- 53. Neurogenomic and Neuroproteomic Approaches to Studying Neural Injury -- 54. Breakthroughs of the Last Twenty Years.
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  • Introduction to stem cells -- Basic biology/mechanisms -- Tissue and organ development -- Methods -- Applications -- Regulation and ethics.
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    Anesthesiology / Susan L. Polk ... [et al.] -- Pediatric surgery: surgical diseases of children / Philip J. Wolfson ... [et al.] -- Plastic surgery: diseases of the skin and soft tissue, face, and hand / Garrett A. Wirth and Gregory R.D. Evans -- Cardiothoracic surgery: diseases of the heart, great vessels, and thoracic cavity / Alan Spotnitz, Marshall L. Jacobs, and Manisha R. Shende -- Otolaryngology: diseases of the head and neck / Gerald Berke ... [et al.] -- Orthopedic surgery: diseases of the musculoskeletal system / John J. Murnaghan -- Urology: diseases of the genitourinary system / Joel Gelman, Barry P. Duel, and Isaac Yi Kim -- Neurosurgery: diseases of the nervous system / Mark E. Linskey -- Ophthalmology: diseases of the eye / Alan S. Crandall Jr. ... [et al.].
  • Introduction to the nervous system -- Development of the nervous system -- Gross anatomy and general organization of the central nervous system -- Meningeal coverings of the brain and spinal cord -- Ventricles and cerebrospinal fluid -- Blood supply of the brain -- Electrical signaling by neurons -- Synaptic transmission between neurons -- Sensory receptors and the peripheral nervous system -- Spinal cord -- Organization of the brainstem -- Cranial nerves and their nuclei -- The chemical senses of taste and smell -- Hearing and balance : the eighth cranial nerve -- Brainstem summary -- The thalamus and internal capsule : getting to and from the cerebral cortex -- The visual system -- Overview of motor systems -- Basal ganglia -- Cerebellum -- Control of eye movements -- Cerebral cortex -- Drives and emotions : the hypothalamus and limbic system -- Formation, modification, and repair of neuronal connections.
  • Also available: Print – 2005
  • Diagnosis and imaging -- Surgical and endovascular technique and tools -- Peripheral arterial thrombosis/emboli -- Compartment syndrome -- Diabetic foot infection -- PAD and claudication -- Critical limb ischemia -- Lower extremity amputations -- Deep venous thrombosis -- Superficial thrombophlebitis -- Chronic venous insufficiency -- Varicose veins -- Inferior vena cava filters -- Vascular injuries in the neck -- Vascular injuries in the abdomen -- Extremity vascular injuries -- Temporary venous catheters -- Arteriovenous hemodialysis access -- Access complications -- Arterial occlusive disease: carotid, mesenteric, renal -- Aortic pathology: AAA, dissection, traumatic transection -- Non-atherosclerotic vascular disease: vasculitis, popliteal entrapment, hypercoaguable -- Surgical and endovascular complications: infection, hemorrhage.
  • This book contains a collection of instructional course lectures given during the 15th ESSKA (European Society of Sports Traumatology, Knee Surgery and Arthroscopy) Congress, held in Geneva during May 2012. The lectures cover a wide range of hot topics in the field, including diverse injuries and management techniques. Each lecture has a practical focus and provides an up-to-date synthesis of core knowledge on the subject in question with the aid of high-quality illustrations. Take home messages and key recommendations are highlighted. This book will be of value to practitioners and researchers alike.
  • This book provides an update on a wide variety of hot topics in the field of knee surgery, sports trauma, and arthroscopy, covering the latest developments in basic science and clinical and surgical methods. It comprises the Instructional Course Lectures delivered at the 16th ESSKA Congress, which was held in Amsterdam during May 2014 and brought together the worlds leading orthopaedic and sports physicians. The contributions are all written by European and international experts in their field. Each lecture has a practical focus and provides an up-to-date synthesis of core knowledge on the subject in question with the aid of high-quality illustrations. Take home messages and key recommendations are highlighted. This book will be of value to practitioners and researchers alike.
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  • Normality, disease and enhancement / Theodore M. Benditt -- Holistic theories of health as applicable to non-human living beings / Lennart Nordenfelt -- Disease and the concept of supervenience / Robert D'Amico -- Decision and discovery in defining disease / Peter H. Schwartz -- Race and scientific reduction / Mark Risjord -- Towards an adequate account of genetic disease / Kelly C. Smith -- Why disease persists / Robert L. Perlman -- Creating mental illness in non-disordered community populations / Allan V. Horwitz -- Gender identity disorder / Jennifer McKitrick -- Clinical trials as nomological machines / Robyn Bluhm -- The social epistemology of NIH consensus conferences / Miriam Solomon -- Maternal agency and the immunological paradox of pregnancy / Moira Howes -- Violence and public health / Jonathan Kaplan -- Taking equipoise seriously / Fred Gifford.
  • "Help your patients look better and improve their self-esteem with this complete, user-friendly guide to all of the latest esthetic dentistry procedures that are in high demand. Thoroughly updated by the most renowned leaders in the field, the new third edition of Esthetic Dentistry: A Clinical Approach to Techniques and Materials offers clearly highlighted techniques in step-by-step fashion, with unmistakable delineation of armamentarium, for the treatment of esthetic problems. Hundreds of clinical tips are included throughout the book to help alert you to potential problems, variations on techniques, and other treatment considerations. Plus, an invaluable troubleshooting guide covers the different types of esthetic problems (such as size, discoloration, and spacing issues), potential solutions, and references to chapters where the specific problem is discussed in detail. With this expert reference in hand, you will have all you need to master the latest esthetic procedures that your patients want!"--Publisher's description.
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  • Advances in our understanding of the brain and rapid advances in the medical practice of neurology are creating questions and concerns from an ethical and legal perspective. Ethical and Legal Issues in Neurology provides a detailed review of various general aspects of neuroethics, and contains chapters dealing with a vast array of specific issues such as the role of religion, the ethics of invasive neuroscience research, and the impact of potential misconduct in neurologic practice. The book focuses particular attention on problems related to palliative care, euthanasia, dementia, and neurogenetic disorders, and concludes with examinations of consciousness, personal identity, and the definition of death. This volume focuses on practices not only in North America but also in Europe and the developing world. It is a useful resource for all neuroscience and neurology professionals, researchers, students, scholars, practicing clinical neurologists, mental health professionals, and psychiatrists. A comprehensive introduction and reference on neuroethicsIncludes coverage of how best to understand the ethics and legal aspects of dementia, palliative care, euthanasia and neurogenetic disorders. Brings clarity to issues regarding ethics and legal responsibilities in the age of rapidly evolving brain science and related clinical practice.
  • The "Ethics Job" -- Why Research Ethics? Why Ethics in Genetics? The Case of Genomics Research -- What Ethics Is, What It Is Not, and How We Are Going to Proceed -- Starting Analysis in Ethics: A Practical Guide -- An Overview of Research Ethics and Challenges from Genomics -- Autonomy and Its Limits: The View from Genomics -- The Social and Institutional Setting of Ethics -- Respect for Persons in Research and in Genetics -- Responsibilities of Researchers in Genetics -- Data Sharing in Genomics.
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  • 1. Introduction -- 2. How babies die and why this is important to clinicians, researchers and parents -- 3. When do we become a person and why should it matter to pediatricians? -- 4. Neonates are devalued compared to older patients -- 5. Who makes it to the NICU? The association between prenatal decisions and neonatal outcomes -- 6. Termination of pregnancy and perinatal palliative care in the case of fetal anomaly: why is there so much incoherence? -- 7. Predicting outcomes in the very preterm infant -- 8. Predicting the future of preterm infants: should we use quality of life and social determinants criteria? -- 9. End-of-life decisions in neonatology from a children's rights perspective: Dutch developments examined -- 10. The lure of technology: considerations in newborns with technology-dependence -- 11. Making tough ethical choices in a morally pluralistic world.
  • Ethical Dilemmas Due to Prenatal and Genetic Diagnostics: An Interdisciplinary, European Study (EDIG, 2005-2008) / Marianne Leuzinger-Bohleber -- Managing Complex Psychoanalytic Research Projects Applying Mapping Techniques - Using the Example of the EDIG Study / Nicole Pfenning-Meerkötter -- Distress and Ethical Dilemmas Due to Prenatal and Genetic Diagnostics - Some Empirical Results / Tamara Fischmann -- Reconstruction of Pregnant Women's Subjective Attitudes Towards Prenatal Diagnostics - A Qualitative Analysis of Open Questions / Katrin Luise Läzer -- Prenatal Testing: Women's Experiences in Case of a Conspicuous Test Result / Elisabeth Hildt -- Caring for Women During Prenatal Diagnosis: Personal Perspectives from the United Kingdom / Helen Statham and Joanie Dimavicius -- Cooperation Is Rewarding If the Boundary Conditions Fit: Interdisciplinary Cooperation in the Context of Prenatal Diagnostics / Astrid Riehl-Emde, Anette Bruder, Claudia Pauli-Magnus, and Vanessa Sieler -- Prenatal Genetic Counselling: Reflections on Drawing Policy Conclusions from Empirical Findings / Anders Nordgren -- Taking Risk in Striving for Certainty. Discrepancies in the Moral Deliberations of Counsellors and Pregnant Women Undergoing PND / László Kovács -- Ethical Thoughts on Counselling and Accompanying Women and Couples Before, During and After Prenatal Diagnosis / Dierk Starnitzke -- Client, Patient, Subject; Whom Should We Treat? On the Significance of the Unconscious in Medical Care and Counselling / Yair Tzivoni -- Decision to Know and Decision to Act / Regina Sommer -- Moral Decision-Making, Narratives and Genetic Diagnostics / Göran Collste -- Prenatal Diagnostics and Ethical Dilemmas in a Mother Having a Child with Down Syndrome / Maria Samakouri, Evgenia Tsatalmpasidou, Konstantia Ladopoulou, Magdalini Katsikidou, Miltos Livaditis, and Nicolas Tzavaras -- Is There One Way of Looking at Ethical Dilemmas in Different Cultures? / Stephan Hau.
  • Behavioral neuroscience encompasses the disciplines of neurobiology and psychology to study mechanisms of behavior. This volume provides a contemporary overview of the current state of how ethics informs behavioral neuroscience research. There is dual emphasis on ethical challenges in experimental animal approaches and in clinical and nonclinical research involving human participants.
  • Also available: Print – 2008
  • Recent surveys demonstrate a high and possibly increasing prevalence of mental disorders in prisoners. They have an increased risk of suffering from a mental disorder that transcends countries and diagnoses. Ethical dilemmas in prison psychiatry arise from resource allocation and include issues of patient choice and autonomy in an inherently coercive environment. Ethical conflicts may arise from the dual role of forensic psychiatrists giving raise to tensions between patient care/protection of the public. This book describes models and ethical issues of psychiatric healthcare in prison in several countries. Relevant issues are: the professional medical role of a psychiatrist and/or psychotherapist working in prison, the involvement of psychiatrists in disciplinary or coercive measures; consent to treatment, the use of coercion in forcing a prisoner to undergo treatment, hunger strike, confidentiality. The book ends with consensus guidelines concerning good practice in Prison Psychiatry.
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    Growing pains -- Ethics is the key -- Problems of practice -- The search for morality -- Persons and potentials -- Theories of ethics -- Obstacles to clear moral reasoning -- The rings of uncertainty -- The background to the ethical grid -- The use of the ethical grid -- The values exchange.
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    Historical foundations / Steven S. Coughlin -- Moral foundations / Tom L. Beauchamp -- Toward a philosophy of epidemiology / Douglas L. Weed -- Epidemiology and informed consent / Jeffrey P. Kahn and Anna C. Mastroianni -- Privacy and confidentiality in epidemiology : special challenges of using information obtained without informed consent / Ellen Wright Clayton -- Ethical issues in the design and conduct of community-based intervention studies / Karen Glanz, Michelle C. Kegler, and Barbara K. Rimer -- Ethical issues in the interaction with research subjects and the disclosure of results / Andrea Smith and Paul A. Schulte -- Ethical issues in public health practice / Robert E. McKeown and R. Max Learner -- Ethical issues in genetic epidemiology / Laura M. Beskow and Wylie Burke -- Ethics and epidemiology in the age of AIDS / Carol Levine -- Ethical issues in international health research and epidemiology / John D.H. Porter, Carolyn Stephens, and Anthony Kessel -- The institutional review board / Robert J. Levine -- Good conduct in integrity in epidemiologic research / Colin L. Soskolne ... [et al.] -- Ethics curricula in epidemiology / Kenneth W. Goodman and Ronald J. Prineas.
  • Ethics and intersex 2006
    "This collection of 21 articles is designed to serve as a state-of-the art reference book for intersexuals, their parents, health care professionals, ethics committee members and anyone interested in problems associated with intersexuality. It fills an important need because of its uniqueness as an interdisciplinary effort, bringing together not just urologists and endocrinologists, but gynecologists, psychiatrists, psychologists lawyers, theologians, gender theorists, medical historians, and philosophers."--Jacket.
  • Introduction: in search of ethics expertise -- Socrates and moral expertise -- Aristotle's moral expert: the phronimos -- Hume on true and false philosophy -- Moral expertise: a millian perspective -- The ineffable and the incalculable: G. E. Moore on ethical expertise -- Expert moral choice in medicine: a study of uncertainty and locality -- Societal consensus and the problem of consent: refocusing the problem of ethics expertise in liberal democracies -- Ethical expertise, maternal thinking, and the work of clinical ethicists -- The roles of scientific and normative expertise in public policy formation: the anthrax vaccine case -- Philosophers return to the agora -- Ethical expertise in the clinical setting -- Bioethical expertise in health care organizations -- The expert ethics witness as teacher.
  • Increasingly, biomedical scientists and engineers are involved in projects, design, or research and development that involve humans or animals. The book presents general concepts on professionalism and the regulation of the profession of engineering, including a discussion on what is ethics and moral conduct, ethical theories and the codes of ethics that are most relevant for engineers. An ethical decision-making process is suggested. Other issues such as conflicts of interest, plagiarism, intellectual property, confidentiality, privacy, fraud, and corruption are presented. General guidelines, the process for obtaining ethics approval from ethics Review Boards,and the importance of obtaining informed consent from volunteers recruited for studies are presented. A discussion on research with animals is included. Ethical dilemmas focus on reproductive technologies, stem cells, cloning, genetic testing, and designer babies. The book includes a discussion on ethics and the technologies of body enhancement and of regeneration. The importance of assessing the impact of technology on people, society, and on our planet is stressed. Particular attention is given to nanotechnologies, the environment, and issues that pertain to developing countries. Ideas on gender, culture, and ethics focus on how research and access to medical services have, at times, been discriminatory towards women. The cultural aspects focus on organ transplantation in Japan, and a case study of an Aboriginal child in Canada; both examples show the impact that culture can have on how care is provided or accepted. The final section of the book discusses data collection and analysis and offers a guideline for honest reporting of results, avoiding fraud, or unethical approaches. The appendix presents a few case studies where fraud and/or unethical research have occurred.
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    Considering moral philosophies and principles -- Resolving ethical issues -- Developing organizational values, vision, and mission -- Codes of ethics in health services -- Organizational responses to ethical problems -- Conflicts of interest and fiduciary duty -- Ethical issues regarding organization and staff --Ethical issues regarding patients and community -- Consent -- Dying and death -- Patient autonomy: the paradigm of physician-assisited suicide -- Ethics in marketing and managed care -- Ethics in resource allocation -- Social responsibility.
  • Ethics in medicine 2014
    Medical ethics and the medical profession are inseparable, yet the formal teaching of medical ethics is a relatively new phenomenon. Furthermore, since the introduction of managed health care, with the physician becoming a 'health provider' and the patient a 'client', the whole concept of medical ethics has undergone a sea change. The contractual relationship between the provider and the client engenders caution and precaution, resulting in defensive medicine. This book both presents a succinct history of medical ethics and discusses a wide range of important ethical dilemmas in the provision of modern health care. A synopsis is provided of ethics through the ages and the role of ethics in the evolution of medicine. Principles and sources of medical ethics, as well as different religious and secular perspectives, are explained. Ethical concerns in relation to a variety of specific issues are then examined. These issues include, for example, human experimentation, stem cell research, assisted reproductive technologies, termination of pregnancy, rationing of health care, euthanasia, and quality of life issues. The author's many years of practicing medicine in different cultures and countries and his passion for religious works, philosophy, literature, poetry, history, and anthropology have informed and enriched the contents of this stimulating book.
  • pt. 1. The context -- pt. 2. Principles of ethics in psychiatry -- pt. 3. The applications of the ethical principles in psychiatric practice and research -- pt. 4. Non-medical uses of psychiatry -- pt. 5. Teaching ethics in psychiatry -- pt. 6. Conclusions and summary.
  • Biobank research and genomic information are changing the way we look at health and medicine. Genomics challenges our values and has always been controversial and difficult to regulate. In the future lies the promise of tailored medical treatments and pharmacogenomics but the borders between medical research and clinical practice are becoming blurred. We see sequencing platforms for research that can have diagnostic value for patients. Clinical applications and research have been kept separate, but the blurring lines challenges existing regulations and ethical frameworks.Then how do we regulate it? This book contains an overview of the existing regulatory landscape for biobank research in the Western world and some critical chapters to show how regulations and ethical frameworks are developed and work. How should international sharing work? How design an ethical informed consent? An underlying critique: the regulatory systems are becoming increasingly complex and opaque. The international community is building systems that should respond to that. According to the authors in fact, it is time to turn the ship around. Biobank researchers have a moral responsibility to look at and assess their work in relation to the bigger picture: the shared norms and values of current society. Research ethics shouldn?t only be a matter of bioethicists writing guidelines that professionals have to follow. Ethics should be practiced through discourse and regulatory frameworks need to be part of that public discourse. Ethics review should be then not merely application of bureaucracy and a burden for researchers but an arena where researchers discuss their projects, receive advice and practice their ethics skills.
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    Foreword: Shopping at the genetic supermarket / Peter Singer -- Is inheritable genetic modification the new dividing line? / John E.J. Rasko ... [et al.] -- The science of inheritable genetic modification / John E.J. Rasko, Douglas J. Jolly -- Nuclear cloning, embryonic stem cells, and gene transfer / Rudolf Jaenisch -- Controlling bodies and creating monsters: popular perceptions of genetic modifications / Christoph Rehmann-Sutter -- Inheritable genetic modification as moral responsibility in a creative universe / Denis Kenny -- Ethics and welfare issues in animal genetic modification / Gabrielle M. O'Sullivan -- Radical rupture: exploring biologic sequelae of volitional inheritable genetic modification / Francoise Baylis, Jason Scott Robert -- "Alter-ing" the human species? Misplaced essentialism in science policy / Eric T. Juengst -- Traditional and feminist bioethical perspectives on gene transfer: is inheritable genetic modification really the problem? / Rosemarie Tong -- Inheritable genetic modification and disability: normality and identity / Jackie Leach Scully -- Regulating genetic modification: clinical applications and genetic counseling considerations / Joan A. Scott -- Can bioethics speak to politics about the prospect of inheritable genetic modification? If so, what might it say? / Roberta M. Berry -- Glossary of scientific terms / John E.J. Rasko ... [et al.].
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    Human value development -- Decision making in value issues -- Basic principles of health care ethics -- The nature of rights in ethical discourse -- Confidentiality and the management of health care information -- Professional gatekeeping as a function of role fidelity -- Autonomy vs. paternalism: a contest between values -- Justice and the allocation of scarce resources -- Withholding and withdrawing life support -- Euthanasia: practice and principles -- Reproductive issues -- AIDS and health care practice -- Ethical issues and genetic manipulation -- Culturally appropriate health care -- Appendix: codes of professional ethics, selected health professions.
  • Pt. 1. Research biobanking : the traditional approach -- Consent to biobank research : one size fits all? / Bjørn Hofmann, Jan Helge Solbakk, Søren Holm -- What no one knows cannot hurt you : the limits of informed consent in the emerging world of biobanking / Arthur L. Caplan -- Users and uses of the biopolitics of consent : a study of DNA banks / Pascal Ducournau and Anne Cambon-Thomsen -- Information rights on the edge of ignorance / Anne Maria Skrikerud -- The dubious uniqueness of genetic information / Anne Maria Skrikerud -- Duties and rights of biobank participants : principled autonomy, consent, voluntariness and privacy / Lars Øystein Ursin -- Biobanking and disclosure of research results : addressing the tension between professional boundaries and moral intuition / Lynn G. Dressler -- Biobanks and our common good / Erik Christensen -- Trust, distrust and co-production : the relationship between research biobanks and donors / Pascal Ducournau and Roger Strand -- Scientific citizenship, benefit, and protection in population-based research / Vilhj́almur Árnason -- Pt. 2. Research Biobanking : towards a new conceptual approach -- Mapping the language of research biobanking : an analogical approach / Bjørn Hofmann, Jan Helge Solbakk, Søren Holm -- The use of analogical reasoning in umbilical cord blood biobanking / Bjørn Hofmann, Jan Helge Solbakk, Søren Holm -- The Alexandria plan : creating libraries for human tissue research and therapeutic use / Laurie Zoloth -- The art of biocollections / Anne Hambro Alnæs -- The health dugnard : biobank participation as the solidary pursuit of the common good / Lars Øystein Ursin and Berge Solberg -- Embodied gifting : reflections on the role of information in biobank recruitment / Klaus Hoeyer -- Conscription to biobank research? / Bjørn Hofmann, Jan Helge Solbakk, Søren Holm -- Ownership rights in research biobanks : do we need a new king of 'biological property'? / Paula Lobato de Faria -- Legal challenges and strategies in the regulation of research biobanking / Elisabeth Rynning -- Annexation of life : the biopolitics of industrial biology / Jan Reinert Karlsen and Roger Strand -- In the ruins of Babel : should biobank regulations be harmonized / Jan Reinert Karlsen, Jan Helge Solbak, and Roger Strand.
  • "Medical or health-oriented screening programs are amongst the most debated aspects of health care and public health practices in health care and public health ethics, as well as health policy discussions. In spite of this, most treatments of screening in the research literature restrict themselves to isolated scientific aspects, sometimes complemented by economic analyses or loose speculations regarding policy aspects. At the same time, recent advances in medical genetics and technology, as well as a rapidly growing societal focus on public health concerns, inspires an increase in suggested or recently started screening programs. This book involves an in-depth analysis of the ethical, political and philosophical issues related to health-oriented screening programs. It explores the considerations that arise when heath care interacts with other societal institutions on a large scale, as is the case with screening: What values may be promoted or compromised by screening programs? What conflicts of values do typically arise - both internally and in relation to the goals of health care, on the one hand, and the goals of public health and the general society, on the other? What aspects of screening are relevant for determining whether it should be undertaken or not and how it should be organised in order to remain defensible? What implications does the ethics of screening have for health care ethics as a whole? These questions are addressed by applying philosophical methods of conceptual analysis, as well as models and theories from moral and political philosophy, medical ethics, and public health ethics, to a large number of ongoing and proposed screening programs which makes this book the first comprehensive work on the ethics of screening. Analyses and suggestions are made that are of potential interest to health care staff, medical researchers, policy makers and the general public"--Provided by publisher.
  • Introduction: the scope of the topic -- Racial and ethnic groups of interest in fertility research -- The impact of sociocultural and economic factors -- Fertility differences among ethnic groups -- Disparities between black and white women in assisted reproductive technology -- Assisted reproductive outcomes in hispanic patients -- Reproductive and assisted reproductive technology (ART) outcomes in East Asian women -- Differences in fertility and assisted reproduction in South Asian women -- Ethnicity and IVF -- Ethnic disparity in oocyte donation outcome -- Frozen embryo transfer outcomes among racial and ethnic groups -- Understanding racial disparity in adverse pregnancy outcome -- Racial diversity and uterine leiomyoma -- The effect of obesity on fertility and ART success among ethnic groups -- Polycystic ovary syndrome across racial and ethnic groups -- Ethnicity and ovariean response: the role of FSH receptor genotype -- Ethnic differences in fertility and assisted reproduction: ethnic disparity in stem cell availability and research -- How can we bridge the gap? Role of insurance mandate -- Toward a better understanding of racial disparities in utilization and outcomes of IVF treatment in the USA.
  • Essential concepts and foundations / Anthony J. Marsella ... [et al.] -- Promoting disaster recovery in ethnic-minority individuals and communities / Fran H. Norris and Margarita Alegría -- Meeting the physical, psychological, and social needs of African Americans following a disaster / Steven B. Carswell and Melisssa A. Carswell -- Essential information for disaster management and trauma specialists working with American Indians / Jeannette L. Johnson ... [et al.] -- Arab Americans : understanding their challenges, needs, and struggles / Naji Abi-Hashem -- Asian Indians : cultural considerations for disaster workers / B.J. Prashantham -- Caribbean blacks : (Haitians, Jamaicans, Virgin Islanders, Eastern Caribbean) responses to disasters in cultural context / G. Rita Dudley-Grant and Wayne Etheridge -- Chinese Americans : guidelines for disaster mental health workers / Frederick T.L. Leong and Szu-Hui Lee -- The Kanaka Maoli : native Hawaiians and their testimony of trauma and resilience / Laurie D. McCubbin, Michele E. Ishikawa, and Hamilton I. McCubbin -- Mexicans, Mexican Americans, Caribbean, and other Latin Americans / Patricia Arredondo, Veronica Bordes, and Freddy A. Paniagua -- Working with Vietnamese Americans in disasters / Aaron S. Kaplan and Uyen Kim Huynh -- Culture, trauma, and the treatment of post-traumatic syndromes : a global perspective / John P. Wilson -- A brief list of disaster-related vocabulary terms -- Summary and overview of disasters in developing countries / Fran H. Norris -- Disaster rescure and response workers / Bruce H. Young, Julian D. Ford, and Patricia Watson.
  • Anti-Inflammatory Plants -- Plants Affecting the Central Nervous System -- Plants for Chemotherapy of Neoplastic Diseases.
  • Etiology of periodontal disease: dental plaque and calculus -- Periodontal microbiology -- Particular aspects of periodontal disease pathogenesis -- Interrelationships between periodontal disease and mortality, cardiovascular disease, metabolic syndrome, diabetes mellitus -- Interrelationships between periodontal disease and adverse pregnancy outcomes, respiratory disease, rheumatoid arthritis, renal disease, cancer, inflammatory bowel disease, Alzheimer disease; Assessing confounding and effect modification -- Genetic variability and periodontal disease -- Implication of systemic osteoporosis on oral health -- Psychological pathways in the pathogenesis of periodontal disease -- Periodontal-restorative interactions -- Endodontic and periodontal interrelationship -- Occlusal considerations in pathogenesis of periodontal disease -- Orthodontics and periodontics.
  • Atopic dermatitis has been called "the itch that rashes", and this book reveals what causes the "itch". It presents completely new and unique findings in eczema: sweat ducts that become occluded with staphylococcal biofilms trigger the innate immune system with TLR2 receptor activity and this leads to production of the "itching" and inflammation in this disease. The Etiology of Atopic Dermatitis details new concepts that bacterial biofilms occlude sweat ducts, trigger the innate immune system, and produce the lesions in atopic dermatitis. The author discusses the findings in terms of microbiology, pathology, immunology, genetics, physiology, treatment, diseases where eczema is considered a secondary component, and diseases not previously thought to be eczema, and followed by an epilogue where eczema and psoriasis are compared. Both these diseases are caused by bacteria, but neither one can be considered an infection. As such, this book is for all who take care of patients with atopic dermatitis, including dermatologists, pediatricians, family practice doctors, allergists and pathologists. It will also be interesting for those involved in research in microbiology, physiology, immunology, and genetics.
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  • pt. 1. Food safety -- pt. 2. Informing the consumer -- pt. 3. Case studies.
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    Flight from Europe, 1929-1939 -- An American education, 1939-1948 -- Medical education and training, 1948-1952 -- Internship and research at Mount Sinai and Bellevue, 1952-1955 -- Clinical associate at the NIH, 1955-1957 -- Johns Hopkins Hospital, 1957-1958 -- The "Golden Years" at the NIH 1958-1968 -- Building a medical school in San Diego, 1968-1972 -- Rebuilding the Brigham, 1972-1980 -- Growth and integration, 1980-1996 -- Research in evolution -- Textbooks and education in evolution -- The still years.
  • Also available: Print – 2005
    Introduction -- 1. Race betterment and tropical medicine in imperial San Francisco -- 2. Quarantine and eugenic gatekeeping on the U.S-Mexico border -- 3. Instituting eugenics in California -- 4. California's eugenic landscapes -- 5. Centering eugenics on the family -- 6. Contesting hereditarianism: reassessing the 1960s -- Epilogue.
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    The early eukaryotic fossil record / Emmanuelle J. Javaux -- The diversity of eukaryotes and the root of the eukaryotic tree / Henner Brinkmann and Hervé Philippe -- Origin of eukaryotic endomembranes: a critical evaluation of different model scenarios / Gáspár Jékely -- Origins and evolution of cotranslational transport to the ER / Thomas U. Schwartz -- Evolution of the endoplasmic reticulum and the Golgi complex / Alexander A. Mironov ... [et al.] -- An evolutionary perspective on eukaryotic membrane trafficking / Cemal Gurkan, Atanas V. Koulov, and William E. Balch -- Reconstructing the evolution of the endocytic system: insights from genomics and molecular cell biology / Mark C. Field, Carme Gabernet-Castello, and Joel B. Dacks -- Origins and evolution of the actin cytoskeleton / Francisco Rivero and Fatima Cvrčková -- Origin and evolution of self-consumption: autophagy / Timothy Hughes and Tor Erik Rusten -- Origin and evolution of the centrosome / Michel Bornens and Juliette Azimzadeh -- The evolution of eukaryotic cilia and flagella as motile and sensory organelles / David R. Mitchell.
  • Composition and Dynamics of the Eukaryotic Replisome: A Brief Overview / Stuart MacNeill -- Evolutionary Diversification of Eukaryotic DNA Replication Machinery / Stephen J. Aves, Yuan Liu and Thomas A. Richards -- The Origin Recognition Complex: A Biochemical and Structural View / Huilin Li and Bruce Stillman -- Archaeal Orc1/Cdc6 Proteins / Stephen D. Bell -- Cdt1 and Geminin in DNA Replication Initiation / Christophe Caillat and Anastassis Perrakis -- MCM Structure and Mechanics: What We Have Learned from Archaeal MCM / Ian M. Slaymaker and Xiaojiang S. Chen -- The Eukaryotic Mcm2-7 Replicative Helicase / Sriram Vijayraghavan and Anthony Schwacha -- The GINS Complex: Structure and Function / Katsuhiko Kamada -- The Pol [alpha]-Primase Complex / Luca Pellegrini -- The Structure and Function of Replication Protein A in DNA Replication / Aishwarya Prakash and Gloria E. O. Borgstahl -- Structural Biology of Replication Initiation Factor Mcm10 / Wenyue Du, Melissa E. Stauffer and Brandt F. Eichman -- Structure and Function of Eukaryotic DNA Polymerase [delta] / Tahir H. Tahirov -- DNA Polymerase [epsilon] / Matthew Hogg and Erik Johansson -- The RFC Clamp Loader: Structure and Function / Nina Y. Yao and Mike O'Donnell -- PCNA Structure and Function: Insights from Structures of PCNA Complexes and Post-translationally Modified PCNA / Lynne M. Dieckman, Bret D. Freudenthal and M. Todd Washington -- The Wonders of Flap Endonucleases: Structure, Function, Mechanism and Regulation / L. David Finger, John M. Atack, Susan Tsutakawa, Scott Classen and John Tainer, et al. -- DNA Ligase I, the Replicative DNA Ligase / Timothy R. L. Howes and Alan E. Tomkinson.
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  • European instructional lectures v. 9-, 2009-
  • This thirteenth volume in the EUROPEAN INSTRUCTIONAL LECTURES series continues the format of educational chapters from across Orthopaedics and Traumatology contributed by distinguished Orthopaedic Educators in Europe. It provides current material and major advances covering a range of topics including: General Orthopaedics, Basic Science and Technology, Musculo-skeletal Tumours, Infections, Paediatric Orthopaedics, Trauma, Spine, Upper Limb, Hip, Knee, Leg, Ankle and Foot. All the lectures were presented at the 14th EFORT Congress in Istanbul, Turkey.
  • Part 1. Musculo-skeletal Trauma -- The Spectrum of Polytrauma. A Pragmatic Approach for the Musculo-Skeletal Surgeon / Pierre Hoffmeyer and Robin Peter -- Proximal Femoral Fractures / Christopher G. Moran and M. Gaden -- Acute Infections After Osteosynthesis / Volkmar Heppert -- Part 2. Musculo-skeletal Tumours -- The Multi-modal Approach to Metastatic Disease / Minna Laitinen, Maire Ratasvuori and Toni-Karri Pakarinen -- How to Manage Osteolytic Lesions / Jendrik Hardes -- Part 3. Paediatrics -- Developmental Hip Dysplasia - A Problem Solved? / Michael K. D. Benson -- Part 4. Spine -- Infections of the Spine / José Guimarães Consciência, Rui Pinto and T. Saldanha -- Multimodal Treatment of Back Pain / Hans Raimund Casser -- Part 5. Upper Limb -- Proximal Humeral Fractures / Martin Jaeger and N. P. Südkamp -- Part 6. Pelvis and Hip -- Navigation and Hip Surgery / Philippe Merloz -- Re-cementing in Revision Total Hip Replacement / Sarah L. Whitehouse, Matt Wilson, Jonathan R. Howell, Matthew J. W. Hubble and A. John Timperley -- Instability Following Total Hip Arthroplasty / Klaus-Peter Günther, Stephan Kirschner, Maik Stiehler and Albrecht Hartmann -- New Trends in Osteonecrosis of the Femoral Head / Konstantinos N. Malizos and Loukia K. Papatheodorou -- Part 7. Knee -- Patellar Fractures / Jean-Christophe Bel -- Arthroscopic Treatment of Intra-Articular Fractures of the Knee / Reha N. Tandogan -- Treatment of Osteonecrosis of the Knee / Tahsin Beyzadeoglu and Ayberk Onal -- Part 8. Trauma Lower Limb -- Ankle Fractures / Stefan Rammelt and Hans Zwipp -- Part 9. Foot and Ankle -- Treatment of Metatarsalgia / Jean-Luc Besse -- Management of Ankle Osteoarthritis / Matthias G. Walcher, Monika Horisberger, Antony Liddell and Victor Valderrabano.
  • Bone Substitutes in Clinical Work / Jari Salo -- Epidemiology and Variability of Orthopaedic Procedures Worldwide / Maria de Fatima de Pina, Ana Isabel Ribeiro, and Carlos Santos -- Cartilage-Forming Bone Tumours / Antonie H.M. Taminiau, Judith V.M.G. Bovée, Carla S.P. van Rijswijk, Hans A.J. Gelderblom, and Michiel A.J. van de Sande -- The Current State of Treatment for Clubfoot in Europe / Rüdiger Krauspe, Kristina Weimann-Stahlschmidt, and B. Westhoff -- Management of Pelvic Fractures / Peter V. Giannoudis and Frangiskos Xypnitos -- The Reverse Shoulder Prosthesis / Carlos Torrens -- Spine Injury: Polytrauma Management / Benny Dahl -- Surgical Management of Tuberculosis of the Spine / Ahmet Alanay and Deniz Olgun -- Scaphoid Fractures / Joseph J. Dias -- Bearing Surfaces / Theofilos Karachalios and George Karydakis -- Hip Pain in the Young Adult / Moritz Tannast, Christoph E. Albers, Simon D. Steppacher, and Klaus A. Siebenrock -- Bone Loss Around the Acetabular Component / Jonathan Howell and Ben Bolland -- The Uni-Knee: Indications, and Recent Techniques / Sébastien Lustig, Gérard Deschamps, M. Alsaati, C. Fary, and Phillippe Neyret -- Osteotomies Around the Knee / Siegfried Hofmann, Philipp Lobenhoffer, Alex Staubli, and Ronald Van Heerwaarden -- Total Knee Replacement for the Stiff Knee / Philippe Massin -- Surgical Treatment of Displaced Calcaneal Fractures / Zvi Cohen, Gershon Volpin, and Haim Shtarker Forefoot Deformities / Wolfgang Schneider.
  • General Orthopaedics -- Evidence for Medical Treatment for Tertiary Prophylaxis of Osteoporosis -- Surgical Site Infections (SSIs): Risk Factors and Prevention Strategies -- Exercise Therapy as Treatment for Patients with Osteoarthritis of the Knee -- Tumours -- New Trends Based on Experimental Results in the Treatment of Sarcoma -- Surgery for Soft Tissue Sarcomas -- Trauma -- Biologics in Open Fractures -- Classification and Algorithm of Treatment of Proximal Humerus Fractures -- Management of Proximal Tibial Fractures -- Surgical Treatment of Pelvic Ring Injuries -- Paediatrics -- Anatomical Reconstruction of the Hip with SCFE, Justified by Pathophysiological Findings -- Spine -- Treatment of the Aging Spine -- Shoulder and Elbow -- New Trends in Shoulder Arthroplasty -- Surgery of the Elbow: Evolution of Successful Management -- Forearm -- The Forearm Joint -- Hip -- Current Evidence on Designs and Surfaces in Total Hip Arthroplasty -- Risk Factors and Treatment of Dislocations of Total Hip Arthroplasty -- Treatment of Early and Late Infection Following THA -- Knee -- Prevention and Management of Cartilage Injury and Osteoarthritis from Sports -- Meniscal Lesions Today: Evidence for Treatment -- Modern Indications for High Tibial Osteotomy -- Unicompartment Knee Arthroplasty: From Primary to Revision Surgery -- Foot and Ankle -- Osteotomies Around the Ankle.
  • This tenth volume in the EUROPEAN INSTRUCTIONAL LECTURES series continues the format of educational chapters from across Orthopaedics and Traumatology contributed by notable surgeons in Europe. It provides up-to-date material and major advances covering a range of topics including: -General Orthopaedics -Musculo-Skeletal Tumours -Paediatric Orthopaedics -Trauma -Spine -Upper Limb -Hip -Knee -Ankle and Foot All the lectures were presented at the 11th EFORT Congress in Madrid, Spain. The lectures are an authoritative source of information illustrated by radiographs, MRI and CT Scans, operative photographs, tables and line drawings. They are a valuable source of instruction for Surgeons and Trainees alike. This book has been edited by Professor George Bentley. Chairman of Scientific Publications Committee of EFORT.
  • Economics of Orthopaedic Infections: A Bottomless Pit -- Updated Animal Models in Orthopaedics Research -- Fractures and Complications Related To Osteoporosis -- RSA Studies in Implant Research -- Instability of the Ankle -- SCFE: Surgical Options -- Proximal Humerus Fractures in Children and Adolescents -- Pelvic Reconstruction in Oncology -- Knee Injuries in Children -- Prevention of Deep Infection in THA -- Revision in Metal-On-Metal THA: Current Knowledge -- Treatment of PJI -- Microbiology/Biofilm/Antibiotics for Dummies -- Diagnostics In PJI -- Patello-Femoral Prosthesis -- Perioperative Management in TKR -- The Role of THR in Patients with Concomitant Back Pain -- Distal Radius Fractures: Indication for Plate Fixation -- Treatment of Fragility Fractures in the Upper Extremity -- Extra capsular Proximal Femur Fractures: Indications for (Primary) Arthroplasty.
  • Executive summary -- Outlook -- Project background and methodological aspects -- Trends of average food supply in the European Union -- Food availability at the household level in the European Union -- Food consumption in adults on the basis of dietary surveys in European countries -- Energy and nutrient intake in the European Union -- Health and lifestyle indicators in the European Union -- Food and nutrition policies in European countries -- General discussion -- National reports.
  • Executive summary -- Outlook -- Trends of average food supply in the European Union -- Food availability at the household level in the European Union -- Energy and nutrient intake in the European Union -- Health indicators and status in the European Union -- General discussion.
  • Part 1. Cover Stories -- Martine Piccart: Medic and Musician ... / Helen Saul, p. 5-11 -- Gordon McVie: Making Waves / Helen Saul, p. 13-20 -- Agnes Glaus: Softly Softly / Helen Saul, p. 21-27 -- Mariano Barbacid: The Homecoming / Helen Saul, p. 29-36 -- Liisa Elovainio: Tough on Tobacco / Helen Saul, p. 37-45 -- Franco Cavalli: Rebel with (Several) Rauses / Helen Saul, p. 47-54 -- Françoise Meunier: Chameleon Chief / Helen Saul, p. 55-63 -- Jean-Pierre Armand: Sifting Sand / Helen Saul, p. 65-73 -- Silvia Marsoni: The Go-Between / Helen Saul, p. 75-85 -- Harry Bartelink: Putting Europe First / Helen Saul, p. 87-94 -- Nora Kearney: Shaking Up the Big House / Jim McGuigan, p. 95-104 -- Paris and Helen Kosmidis: A Legend in their Own Time / Jim McGuigan, p. 105-115 -- Jacek Jassem: Reaching out From Gdansk / Marc Beishon, p. 117-127 -- Part 2. Masterpieces -- Interview with Umberto Veronesi / Maurice Schneider, p. 131-135 -- Maurice Tubiana: The Fighting Spirit Behind Cancerology / Maurice Schneider and Raphaël Brenner, p. 137-140 -- Michael Baum: Shooting Sacred Cows / Helen Saul, p. 141-149 -- Hans-Jörg Senn: Championing Consensus / Anna Wagstaff, p. 151-158 -- Gianni Bonnadona: Fighting for Every Life / Anna Wagstaff, p. 159-165.
  • This book provides an essential overview of the science of polysaccharides. It both approaches polysaccharides as a polymer class and provides detailed descriptions of most major polysaccharides (cellulose, mannan, xylan, chitin-chitosan, cyclodextrines). Owing to the multidisciplinary character of the European Polysaccharide Network of Excellence (EPNOE), the book describes all main aspects of polysaccharide science and technology (biology, enzymology, physics, chemistry, materials science and processing). Notations and concepts follow a uniform format throughout the whole work in order to create a valuable reference book on the field of polysaccharide science. Owing to the major importance of industry in the EPNOE, concrete applications are also described in detail.
  • "This important reference textbook covers the surgical management of all major orthopaedic and traumatological conditions. The book will act as the major source of education and guidance in surgical practice for surgeons and trainees, especially those preparing for higher surgical examinations and the Board of Orthopaedics and Traumatology examinations within and beyond Europe. The emphasis throughout is on the application of current knowledge and research to technical problems, how to avoid operative problems, and how to salvage complications if they occur. The didactic text is complemented by abundant illustrations that highlight the essentials of each clinical scenario. The authors are all recognized international authorities active at congresses and workshops as well as in universities and hospitals across the world."--Publisher's website.
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    Mayerne and his world -- Early years 1573-1598 -- Paris 1598-1601 -- The grand tour 1599-1601 -- The chemical challenge 1601-1605 -- The German dimension 1605-1606 -- Interlude in England 1606 -- Protestants and Catholics 1600-1610 -- The move to England 1610-1611 -- First years in England 1611-1613 -- Sir Thomas Overbury 1612-1615 -- Secret agent to King James 1614-1615 -- Medical reformer 1615-1616 -- The Protestant revolution 1616-1622 -- Baron d'Aubonne 1620-1621 -- Protector of Switzerland 1622 -- The last years of King James 1623-1625 -- Charles I and the Protestant débâcle 1625-1630 -- A new regime 1630-1631 -- Planting a dynasty 1630-1639 -- Enterpreneur and virtuouso -- The physician and his late years 1640-1655.
  • The EuroQol Group first met in Rotterdam in May 1987 determined to develop a standardised non-disease-specific instrument for valuing health-related quality of life. The book traces the activities of the Group over the next 25 years. The instrument constructed, eventually named the EQ-5D, was translated into many languages and used in a wide range of countries and settings. The book describes how the instrument's descriptive system was determined, how translation and language issues were handled, and how valuations were provided. Recent developments, in particular a 5-level version (EQ-5D-5L), and a youth version (EQ-5D-Y) are covered. The history of the institutional and administrative framework within which the Group operated is also treated.
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    Overview: Emotional public responses to widely publicized right-to-die and euthanasia cases, such as those revolving around Dr. Jack Kevorkian and Terri Schiavo, highlight their volatile mix of medical, ethical, religious, legal, and public policy issues. The Euthanasia/Assisted-Suicide Debate explores how this debate has evolved over the past 100 years as judicial approaches, legislative responses, and prosecutorial practices have shifted as a result of changes in medical technology and consumer sophistication. Emphasizing the period from the 1950s forward, the book offers an unbiased examination of the origins of the modern medical euthanasia and assisted-suicide debates, the involvement of physicians, the history and significance of medical technology and practice, and the role of patients and their families in the ongoing controversy. This illuminating exploration of concepts, issues, and players will help readers understand both sides of the debate as viewed by participants.
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    "This book provides an examination of the regulations that have been successively put into place since the Second World War to standardize the quality and criteria of pharmaceutical products, vaccines and medicines"--Provided by publisher.
  • Entrusted with providing high quality and cost-effective care across the continuum of primary care to quaternary care medicine, health care institutions are turning to electronic medical records to keep pace with the information demands of medicine. The new patient care data collected within electronic medical records provides the computational foundation to build the rapid learning health care system, in which the delivery of health care within an entire institution improves dynamically by transforming the data into knowledge about which clinical practices are most effective. A crucial component to the rapid learning health care system is an understanding of clinical practice variations in medicine. Individual variations in care reflect decision choices of the treating clinician(s). Taken across an entire population, practice variations offer valuable insight on the behaviors and beliefs of an institution. Devising strategies and policies to improve the quality and efficiency of health care would not be possible without the knowledge that studying practice variations provide. Yet, existing methods for measuring clinical practice variations are not designed to handle temporal complexity. They focus on a small set of practices, of limited duration, and with limited scope. With the data that electronic medical records can provide, we have an opportunity to evaluate temporal complexity in medicine by studying patterns of care and entire treatment histories for a population of patients. In this thesis, I present a method, the T3S, for measuring the temporal sequence similarity between two patterns of care. The T3S advances research in temporal data mining by providing methodology that allows for the measurement of complex temporal features in clinical care. Specifically, the T3S measures the similarity of patterns in terms of the temporal ordering, duration, and overlap of its constituent treatments. I implement the T3S in three novel tools that allow population-level clinical practice variations to be studied from electronic medical records. To begin with, I use the T3S with expert derived domain knowledge to match medication treatment data from the medical record to chemotherapy plans so that patterns of care can be abstracted from granular medical data. This automated method for medical record abstraction of treatment information is a crucial first step before clinical data can be analyzed. Next, I use the T3S to find similar patterns of care from an electronic medical record to recommendations from a clinical practice guideline. The evaluation of individual patterns of care against evidence-based guidelines is an important task of health services related outcomes research. Finally, I incorporate the T3S into a new method for discovering patterns of care from a population of treatment histories. I show how this method can be used to summarize the clinical practice patterns within a population cohort and even discover anomalous practice patterns that may be of interest to clinicians and health services researchers. I evaluate each of these methods for its ability to provide clinically meaningful results from the available treatment data. Taken together, the T3S and the methods in which it is implemented offer a novel framework from which temporal complexities in the practice of medicine can be meaningfully explored. Finding and discovering similar patterns of care offers substantial potential in quality of care, outcomes, and comparative effectiveness research. As medicine marches to the digital age of data, measuring temporal similarity will assume a critical role in the development of new informatics methods to address the challenges of population science.
  • Also available: Print – 2007
  • Abdominal aortic aneurysms (AAA's) are characterized by a permanent and irreversible enlargement of the abdominal aorta to at least 150 percent its expected normal size. Endovascular treatment of AAA's with endografts has gained tremendous popularity in the last decade, largely due to decreased perioperative mortality and faster recovery times, when compared to open surgical repair. Although endografts are an appealing treatment option for many patients, some device design and safety issues have yet to be addressed. One of the biggest problems with endografts is their tendency to shift their position in the patient anatomy over time. The forces that cause this shift and their relation to endograft design are not well understood. In addition, the degree of blood damage due to the insertion of an endograft into the abdominal aorta has not been quantified. The following studies were completed in order to investigate the issues described above. 1. Calculation of endograft displacement force in patient-specific device models. This study used electron-beam computed tomography (CT) image data to generate patient-specific anatomical models using novel segmentation techniques. The patient models were then virtually modeled to represent three different endograft designs, based on aortic stent-graft devices already available in the U.S. or currently in clinical trials. Computational Fluid Dynamics (CFD) simulations were run to characterize the hemodynamic factors for each patient and a total displacement force was calculated for each model. Results show that the location of the device bifurcation impacts the overall displacement force, with proximal bifurcation endograft designs generating a lesser force than distal bifurcation designs. 2. Characterization of blood damage due to endograft placement. Patient-specific computational models were created to represent endograft features that partially obstruct blood flow to the renal arteries, which is sometimes necessary to attain complete exclusion of the aneurysm after deploying the device. Findings show that the insertion of an endograft causes a two-fold increase in blood damage. However, the magnitude of blood damage is within acceptable safety standards. 3. Benchtop testing of red blood cell damage. A benchtop experimental setup was created to measure the damage to red blood cells under various flow conditions and flow obstructions. Samples were characterized at different time points using light scatter methods to determine cell volume and hemoglobin concentration. Results indicate that significant damage to red blood cells occurs only after prolonged exposure (> 103 seconds) to high shear (> 4000 dynes/cm2) conditions. In addition, the presence of flow obstructions creates red blood cell fragments, instead of destroying the cells entirely. Future directions for this work include additional CFD modeling of devices in more patients treated with different aortic stent graft designs to derive statistical significance relative to various design and anatomical features and extend the analysis to the evaluation of devices used for the treatment of thoracic aortic aneurysms (TAA's). Follow-up studies on device migration studies can also be completed in the cohort of patients where the endograft displacement forces were calculated. Further, blood damage models that incorporate the fragmentation of red blood cells can be developed.
  • Offers practice guidelines for conducting workplace mental health disability evaluations. This book examines legal and ethical aspects of employment evaluations. It also offers an examination of the process of psychiatric disability development, and discusses issues specific to evaluations for Social Security and other disability benefit programs.
  • Argues that the world must critically assess the potential pitfalls of new technologies in advance. This book addresses methodological issues with regard to the ethical evaluation of new and emerging technology. It focuses on the concept of uncertainty that, unlike the notion of risk, is greatly undervalued in the field of ethics.
  • BACKGROUND: Existing methods for meta-analysis of diagnostic test accuracy focus primarily on a single index test rather than comparing two or more tests that have been applied to the same patients in paired designs. OBJECTIVES: We develop novel methods for the joint meta-analysis of studies of diagnostic accuracy that compare two or more tests on the same participants. DEVELOPMENT OF METHODS: We extend the bivariate meta-analysis method proposed by Reitsma et al. (J Clin Epidemiol. 2005; 58[10]:982-90) and modified by others to simultaneously meta-analyze M e 2 index tests. We derive and present formulas for calculating the within-study correlations between the true-positive rates (TPR, sensitivity) and between the false-positive rates (FPR, one minus specificity) of each test under study using data reported in the studies themselves. The proposed methods respect the natural grouping of data by studies, account for the within-study correlation between the TPR and the FPR of the tests (induced because tests are applied to the same participants), allow for between-study correlations between TPRs and FPRs (such as those induced by threshold effects), and calculate asymptotically correct confidence intervals for summary estimates and for differences between summary estimates. We develop algorithms in the frequentist and Bayesian settings, using approximate and discrete likelihoods to model testing data. APPLICATION: Published meta-analysis of 11 studies on the screening accuracy of detecting trisomy 21 (Down syndrome) in liveborn infants using two tests: shortened humerus (arm bone), and shortened femur (thigh bone). Secondary analyses included an additional 19 studies on shortened femur only. FINDINGS: In the application, separate and joint meta-analyses yielded very similar estimates. For example, in models using the discrete likelihood, the summary TPR for a shortened humerus was 35.3 percent (95% credible interval [CrI]: 26.9, 41.8%) with the novel method, and 37.9 percent (27.7 to 50.3%) when shortened humerus was analyzed on its own. The corresponding numbers for the summary FPR were 4.8 percent (2.8 to 7.5%) and 4.8 percent (3.0 to 7.4%). However, when calculating comparative accuracy, joint meta-analyses resulted in shorter confidence intervals compared with separate meta-analyses for each test. In analyses using the discrete likelihood, the difference in the summary TPRs is 0 percent (8.9, 9.5%; TPR higher for shortened humerus) with the novel method versus 2.6 percent (14.7, 19.8%) with separate meta-analyses. The standard deviation of the posterior distribution of the difference in TPR with joint meta-analyses is half of that with separate meta-analyses. CONCLUSIONS: The joint meta-analysis of multiple tests is feasible. It may be preferable over separate analyses for estimating measures of comparative accuracy of diagnostic tests. Simulation and empirical analyses are needed to better define the role of the proposed methodology.
  • This step-by-step guidebook is designed to help readers understand the importance of evaluation of leadership development initiatives.
  • Overview: theoretical perspectives and methodologies for the evaluation of healthcare information systems -- Qualitative research methods for evaluating computer information systems -- Multiple perspectives: evaluating healthcare information systems in collaborative environments -- Survey methods for assessing social impacts of computers in healthcare organizations -- Using the Internet for surveys and research -- Cognitive approaches to the evaluation of healthcare information systems -- Work-sampling: a statistical approach to evaluation of the effect of computers on work patterns in health care -- Evaluation of health informatics: social network analysis -- Evaluation in health informatics: computer simulation -- Computers in the consulting room: a case study of clinician and patient perspectives -- Introducing physician order entry at a major academic medical center, A: Impact on organizational culture and behavior, B: Impact on medical education -- Evaluating the capability of information technology to prevent adverse drug events: a computer simulation approach -- Implementing computers in ambulatory care: implications of physician practice patterns for system design -- Nursing documentation time during implementation of an electronic medical record -- Computer charting: an evaluation of a respiratory care computer system -- Research and evaluation: future directions.
  • The history of ptosis surgery -- Eyelid anatomy and physiology with reference to blephoraptosis -- Risk factor assessment prior to ptosis surgery -- Ptosis: nailing the diagnosis and considering the differential diagnosis -- Preoperative decision making in ptosis surgery -- Pseudoptosis -- Congenital ptosis -- Involutional ptosis -- Myogenic ptosis -- Myasthenia gravis -- Neurogenic blepharoptosis -- Traumatic blepharoptosis -- Anophthalmic ptosis -- Lash ptosis -- The nonsurgical treatment of ptosis -- External levator resection -- Minimal dissection, small incision ptosis correction -- Muller's muscle-conjunctival resection (posterior approach) -- Open-sky (anterior approach) Muller's muscle resection for the correction of blepharoptosis -- The Fasanella-Servat procedure for ptosis -- Full-thickness eyelid resection for blepharoptosis correction -- Frontalis suspension for the correction of blepharoptosis -- In-office surgery, anesthesia, and analgesia -- Ethnic and gender considerations in ptosis surgery -- Aesthetic considerations for the ptosis surgeon -- Challenging ptosis scenarios -- Ptosis surgery: comparing different surgical techniques -- Ptosis surgery failure and reoperation -- Complications of ptosis repair: prevention and management -- Commentary: perspective of a risk manager: 12 steps of a successful surgical encounter.
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    Structure and function of normal muscle / Robert C. Griggs -- Evaluation of the patient with myopathy / Robert C. Griggs, Emma Ciafaloni -- Genetic evaluation of the patient and family / Gerald Pfeffer, Patrick F. Chinnery -- The muscular dystrophies / Emma Ciafaloni, Robert C. Griggs -- Myofibrillar myopathies / Duygu Selcen -- Congenital myopathies / Francesco Muntoni, Caroline Sewry, Heinz Jungbluth -- Metabolic myopathies / Gráinne S. Gorman, Patrick F. Chinnery -- Mitochondrial myopathy / Gerald Pfeffer, Patrick F. Chinnery -- Muscle channelopathies / Araya Puwanant, Robert C. Griggs -- Inflammatory myopathies / Anthony A. Amato, Andrew Mammen -- Myopathies of systemic disease and toxic myopathies -- Muscle pain and fatigue / Michael R. Rose, Dr. Patrick Gordon -- Prevention and management of systemic complications of myopathies / Wendy M. King, Robert C. Griggs.
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    Challenges of Evaluation in Biomedical Informatics, p. 1-20 -- Evaluation as a Field, p. 21-47 -- Determining What to Study, p. 48-84 -- The Structure of Objectivist Studies, p. 85-112 -- Measurement Fundamentals, p. 113-144 -- Developing and Improving Measurement Methods, p. 145-187 -- The Design of Demonstration Studies, p. 188-223 -- Analyzing the Results of Demonstration Studies, p. 224-247 -- Subjectivist Approaches to Evaluation, p. 248-266 -- Performing Subjectivist Studies in the Qualitative Traditions Responsive to Users / Joan Ash, Allen Smith and P. Starvi, p. 267-300 -- Economic Aspects of Evaluation / Mark Roberts, p. 301-337 -- Proposing and Communicating the Results of Evaluation Studies: Ethical, Legal, and Regulatory Issues, p. 338-361.
  • "There has been explosive growth in the hunt for new pharmaceutically agents globally. Traditionally, this has been the purview of the pharmaceutical industry, but today, this effort crosses academic, government, and industry laboratories across the world. Enzymes remain the most valued and common of drug targets; hence, a detailed understanding of their interactions with inhibitors is critical to successful drug discovery. This book provides a practical, readable, and comprehensive treatment of these topics that allows scientists to master the art of applied enzymology for drug discovery. The book addresses the opportunities for inhibitor interactions with enzyme targets arising from consideration of the catalytic reaction mechanism; discusses how inhibitors are properly evaluated for potency, selectivity, and mode of action, covers the potential advantages and liabilities of specific inhibition modalities with respect to efficacy in vivo, and provides valuable biochemical insights to help medicinal chemists and pharmacologists most effectively pursue lead optimization. It includes two new chapters, one on the pioneering idea of drug-target residence time fostered by Dr. Copeland, and the second on quantitative biochemistry. Five new appendices are added"--Provided by publisher.
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    "This publication provides readers with a thorough understanding of enzyme-inhibitor evaluation to assist them in their efforts to discover and optimize novel drug therapies. Key topics such as competitive, noncompetitive, and uncompetitive inhibition, slow binding, tight binding, and the use of Hill coefficients to study reaction stoichiometry are all presented. Examples of key concepts are presented with an emphasis on clinical relevance and practical applications."--Jacket.
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  • Introduction to Evidence-Based Pathology and Laboratory Medicine -- Evidence-Based Pathology: A Stable Set of Principles for a Rapidly Evolving Specialty -- What Is Best Evidence in Pathology? -- Biostatistics 101 -- Prognostication and Prediction in Anatomic Pathology: Carcinoma of the Breast as an Illustrative Model -- Principles of Classification and Diagnosis in Anatomic Pathology and the Inevitability of Problem Cases -- Evaluating Oncopathological Studies: The Need to Evaluate the Internal and External Validity of Study Results -- Power Analysis and Sample Sizes in Pathology Research -- Meta-Analysis: A Statistical Method to Integrate Information Provided by Different Studies -- Decision Analysis and Decision Support Systems in Anatomic Pathology -- Evidence-Based Approach to Evaluate Information Published in the Pathology Literature and Integrate It with Personal Experience -- Evidence-Based Cell Pathology Revisited: A Personal View -- Development of Evidence-Based Diagnostic Criteria and Prognostic/Predictive Models: Experience at Cedars Sinai Medical Cen -- Evaluation and Reduction of Diagnostic Errors in Pathology Using an Evidence-Based Approach -- Meta-Analysis 101 for Pathologists -- Evidence-Based Practices in Applied Immunohistochemistry: Dilemmas Caused by Cross-Purposes -- Evidence-Based Pathology and Laboratory Medicine in the Molecular Pathology Era: Transition of Tests from the Research Bench into Practice -- The Use of Decision Analysis Tools for the Selection of Clinical Laboratory Tests: Developing Diagnostic and Forecasting Models Using Laboratory Evidence -- Implementation and Benefits of Computerized Physician Order Entry and Evidence-Based Clinical Decision Support Systems -- Evidence-Based Pathology and Tort Law: How Do They Compare?
  • This book offers an evidence based guide for clinical psychologists, psychiatrists, psychotherapists and other clinicians working with trauma survivors in various settings. It provides easily digestible, up-to-date information on the basic principles of traumatic stress research and practice, including psychological and sociological theories as well as epidemiological, psychopathological, and neurobiological findings. However, as therapists are primarily interested in how to best treat their traumatized patients, the core focus of the book is on evidence based psychological treatments for trauma-related mental disorders. Importantly, the full range of trauma and stress related disorders is covered, including Acute Stress Reaction, Complex PTSD and Prolonged Grief Disorder, reflecting important anticipated developments in diagnostic classification. Each of the treatment chapters begins with a short summary of the theoretical underpinnings of the approach, presents a case illustrating the treatment protocol, addresses special challenges typically encountered in implementing this treatment, and ends with an overview of related outcomes and other research findings. Additional chapters are devoted to the treatment of comorbidities, special populations and special treatment modalities, and to pharmacological treatments for trauma-related disorders. The book concludes by addressing the fundamental question of how to treat whom, and when.
  • "Evidence for Health: From Patient Choice to Global Policy is a practical guide to evidence-informed decision-making. It provides health practitioners and policy-makers with a broad overview of how to improve health and reduce health inequities, as well as the tools needed to make informed decisions that will have a positive influence on health. Chapters address questions such as: What are the major threats to health? What are the causes of poor health? What works to improve health? How do we know that it works? What are the barriers to implementation? What are the measures of success? The book provides an algorithm for arriving at evidence-informed decisions that take into consideration the multiple contextual factors and value judgements involved. Written by a specialist in public health with a wealth of international experience, this user-friendly guide demystifies the decision-making process, from personal decisions made by individual patients to global policy decisions"--Provided by publisher.
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  • Evidence Synthesis: Evolving Methodologies to Optimise Patient Care and Enhance Policy Decisions -- Barriers to Evidence Synthesis -- Systematic Review and Meta-analysis in Clinical Practice -- Diagnostic Tests -- An Introduction to Decision Analysis -- An Introduction to Cost-Effectiveness Analysis -- Evidence Synthesis Using Bayesian Belief Networks -- A Practical Introduction to Meta-analysis -- A Practical Approach to Diagnostic Meta-analysis -- Practical Examples of the Application of Decision Analysis in Healthcare -- A Practical Example of Cost-Effectiveness Analysis -- Exploring Bayesian Belief Networks Using Netica®
  • The addictions treatment field is currently undergoing a period of increased scrutiny, upheaval and change. The growing emphasis on treatment accountability and cost effectiveness is leading to major changes in standards of care. Inconsistent practices based solely on clinical intuition rather than hard scientific evidence of treatment efficacy are rapidly becoming unacceptable. Translating science-based treatments into clinical settings is an important priority in the addictions field and has been the subject of an influential Institute of Medicine report. Substance abuse treatment programs.
  • This evidence-based reference, now in a second edition, presents the most current scientific, epidemiological and clinical research on the role of vitamins and minerals in preventing disease and promoting optimal health. Organized by micronutrient, the book covers biological function, deficiency, recommended daily allowance, role in disease prevention and treatment, sources, safety, and interactions with other micronutrients and drugs - all endorsed by the internationally acclaimed Linus Pauling Institute at Oregon State University.
  • This book addresses the increasing demands on cardiology clinicians to manage complex patients with pregnancy, cancer, noncardiac surgery, systemic diseases and concurrent cardiac problems . It provides an up-to-date, detailed, evidence-based approach to key issues facing the consultant including practical clinical advice on the prevention, diagnosis, and treatment of heart disease. Evidence-Based Cardiology Consult addresses the issues specific and relevant to a cardiology consultation and focuses on cardiac issues in both the general medical patient and in specific populations. Topics covered include: The evaluation of chest pain, acute coronary syndromes, heart failure, infective endocarditis, sudden cardiac death, and imaging in cardiology consultation Cardiac problems in women, the elderly and athletes Cardiovascular disease in patients with chronic kidney disease and neurologic disease Pregnancy-related cardiac diseases Cardio-oncology, including cardiac disease resulting from chemotherapy and radiation in oncology patients. This book is a key practical resource for the management of patients with cardiac disease whether it be the primary diagnosis or as a result of other medical conditions. Therefore this is a must read for cardiology trainees and practicing cardiologists, neurologists, physicians in maternalfetal medicine, oncology, nephrology, radiology, and those who participate in preventative medicine programs.
  • The new endocrinologist: evidence-based medicine meets endocrine practice / Victor M. Montori -- A short history of evidence-based medicine / Jeanne Daly -- The philosophy of evidence-based medicine, 15 years later / Gordon H. Guyatt and Jason W. Busse -- Preparing future generations of evidence-based endocrinologists / Michael L. Green -- Finding current best evidence in clinical endocrinology / R. Brian Haynes and Cynthia J. Walker-Dilks -- Integrating evidence into clinical diagnosis / W. Scott Richardson -- Supporting evidence-based endocrine practice / Steven A. Smith and Geoffrey Gates -- Helping patients make decisions at the point of care / Annette M. O'Connor, Dawn Stacey, and France Légaré -- Incorporating evidence into health policy decisions / Eduardo Ortiz and Janelle Guirguis-Blake -- The value of observational studies in endocrinology / L. Joseph Melton III -- The value of clinical investigations in endocrinology / William L. Isley -- Systematic reviews and the Cochrane collaboration in endocrinology / Bernd Richter -- Health-related quality of life of in endocrinology / Holger J. Schnemann and Elie A. Akl -- Using decision analyses in endocrinology / David Aron and Evelyn Mentari -- Clouded thinking: the misguided use of cost-effectiveness analysis and the implications for endocrine interventions / Amiram Gafni -- The value of translational research in diabetes: asking broader questions / Russell E. Glasgow, Elizabeth Bayliss, and Paul A. Estabrooks -- The patient with type 1 diabetes and hypoglycemia / Yogish C. Kudva, Teck-Kim Khoo and Peter J. Tebben -- The patient with medically complicated obesity / Kurt A. Kennel -- The patient at risk of type 2 diabetes: considering prevention / Sarah E. Capes -- The patient with type 2 diabetes and incomplete metabolic control / Sean F. Dinneen and Robert K. Semple -- The patient with diabetes using alternative medicine / Edward J. Mills and Dugald Seely -- The patient with osteoporosis / Clifford J. Rosen and Sue A. Brown -- The neuroendocrinology of medically unexplained syndromes: the example of chronic fatigue syndrome / Jason W. Busse.
  • Hypothalamic-pituitary disorders -- Thyroid disorders -- Adrenal disorders -- Metabolic bone disorders -- Reproductive disorders -- Diabetes mellitus -- Lipid disorders -- Obesity and nutrition -- Multiple endocrine neoplasia -- Carcinoid tumors -- Paraneoplastic endocrine syndromes -- Genetics.
  • Also available: Print – 2007
    Clinical epidemiology / Hussein Hollands and Sanjay Sharma -- Health economics / Hussein Hollands and Sanjay Sharma -- Anterior segment / Ayad A. Farjo and Qais A. Farjo -- Refractive surgery / Louis E. Probst -- Clinical trials in glaucoma / Paul E. Rafuse -- Diabetic retinopathy / Dean Eliott -- Diabetic macular edema / Dean Eliott -- Proliferative diabetic retinopathy / Dean Eliott -- Clinical trials in age-related macular degeneration / Sophie J. Bakri and Peter K. Kaiser -- Treatment of central retinal vein occlusion: lessons from clinical trials / Henry Tseng and Sharon Fekrat -- Treatment of branch retinal vein occlusion: lessons from clinical trials / Henry Tseng and Sharon Fekrat -- Retinal detachment and proliferative vitreoretinopathy / Amani A. Fawzi, Jay M. Stewart, and Michael A. Samuel -- Evidence-based medicine and the treatment of endophthalmitis / Seenu M. Hariprasad and William F. Mieler -- Retinopathy of prematurity / Anna Ells -- Amblyopia / Jonathan M. Holmes, Michael X. Repka, and Raymond T. Kraker -- Uveal melanoma: approaches to management / Ernest Rand Simpson -- Optic neuritis / Jonathan D. Trobe -- Thyroid eye disease / Louise A. Mawn -- Traumatic optic neuropathy / Louise A. Mawn.
  • "Now in a revised and updated Second Edition, this handy guide to eye care uses evidence from the latest clinical trials to deliver practical advice directly applicable to the challenges of daily ophthalmic practice. Helpful illustrations and tables support the text and improve outcomes, summarizes the major clinical trials in ophthalmology that support the current standard of care. Practical focus helps readers apply research findings to day-to-day practice. Logical organization guides readers from general epidemiology to disease-specific sections. Broad scope addresses the full range of ophthalmologic subspecialties--from treatment of corneal defects, glaucoma, and cataracts to management of vitreo-retinal disorders. NEW in the Second Edition ... Results from the latest clinical trials let readers put current findings into practice. Coverage of new pharmacologic agents broadens therapeutic choices. Three new chapters address arterial occlusive disease, non-exudative age-related macular degeneration, and biostatistics"--Provided by publisher.
  • The latest addition to the Evidence-Based Book series, Evidence-Based Geriatric Medicine provides non-geriatrician clinicians an overview of key topics central to the care of the older patient. This guide focuses on the management of common problems in the elderly taking into account their life situations as well as treatment of specific conditions. Leading geriatricians with expertise in evidence-based medicine utilize the best available evidence and present this information in a concise, easy-to-use, question-based format. Evidence-Based Geriatric Medicine is a unique guide to the optimum management of older patients." Fifty-five full-color narrated video clips on the companion DVD show you clinicians and patients performing the techniques described in the text.
  • Also available: Print – 2006
  • "This handbook delivers the assistance you need to provide timely and effective, evidence-based consultations for a range of commonly encountered clinical situations. This book will help you: navigate the most common clinical scenarios requiring medical consultation by reviewing 20-25 clinical questions for each patient type; locate evidence-based answers for each question, collected from the latest clinical findings; and find the information you need quickly thanks to a user-friendly format."--BOOK JACKET.
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    An introduction to monitoring therapeutic interventions in clinical practice / Paul P. Glasziou, Jeffrey K. Aronson -- A framework for developing and evaluating a monitoring strategy / David Mant -- Developing monitoring tools: integrating the pathophysiology of disease and the mechanisms of action of therapeutic interventions / Jeffrey K. Aronson, Susan Michie -- Biomarkers and surrogate endpoints in monitoring therapeutic interventions / Jeffrey K. Aronson -- Choosing the best monitoring tests / Les Irwig, Paul P. Glasziou -- Monitoring the initial response to treatment / Katy Bell, Jonathan Craig, Les Irwig -- Control charts and control limits in long-term monitoring / Petra Macaskill -- Developing a monitoring schedule: frequency of measurement / Andrew J. Farmer -- How should we adjust treatment? / Paul P. Glasziou -- Monitoring as a learning and motivational tool / Susan Michie, Kirsten McCaffery, Carl Heneghan -- Monitoring from the patient's perspective: the social and psychological implications / Kirsten McCaffery, Susan Michie -- Evaluating the effectiveness and costs of monitoring / Patrick M.M. Bossuyt -- Good practice in delivering laboratory monitoring / W. Stuart A. Smellie -- Point-of-care testing in monitoring / Christopher P. Price -- Monitoring for the adverse effects of drugs / Jamie J. Coleman, Robin E. Ferner, Jeffrey K. Aronson -- Monitoring diabetes mellitus across the lifetime of illness / Andrew J. Farmer -- Oral anticoagulation therapy (OAT) / Carl Heneghan, Rafael Perera -- Monitoring cholesterol-modifying interventions / Paul P. Glasziou, Les Irwig, Stephane Heritier -- Monitoring levothyroxine replacement in primary hypothyroidism / Andrea Rita Horvath -- Monitoring in renal transplantation / Nicholas B. Cross, Jonathan Craig -- Monitoring in pre-eclampsia / Pisake Lumbiganon, Malinee Laopaiboon -- Monitoring in intensive care / Jan M. Binnekade, Patrick M.M. Bossuyt -- Monitoring intraocular pressure in glaucoma / Les Irwig ... [et al.] -- Monitoring in osteoarthritis / George Peat ... [et al.].
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    Asking answerable clinical questions -- Acquiring the evidence: how to find current best evidence and have current best evidence find us -- Appraising the evidence -- Therapy -- Diagnosis and screening -- Prognosis -- Harm -- Evaluation -- Teaching EBM.
  • How to search for evidence -- Epidemiology -- Clinical manifestations -- Laboratory tests -- Rational antibiotic use -- Adjunctive treatment -- Bacterial meningitis -- Respiratory tract infections -- Osteomyelitis and septic arthritis -- Urinary tract infections -- Necrotizing enterocolitis and gastrointestinal infections -- Eye infections -- Skin and soft tissue infections -- Bacterial infections -- Mycoplasmas -- Fungal infections -- Viral infections -- Other congenital infections -- Breast milk -- Surveillance -- Infection control -- Developing countries -- Prevention of neonatal infections -- Neonatal antimicrobials.
  • Begins with a review of the concepts and techniques involved in the practice of evidence-based medicine, including the basics of critical analysis using methodologically rigorous evidence-synthesis techniques. The second part of the text provides useful examples of the use of this critical analysis for common clinical situations, such as stent placement, managing infection, metastases, craniocerebral trauma, cervical spine trauma, and more.
  • With the aging population ever growing, healthcare for persons suffering from stroke and related illnesses is increasingly important. Evidence-Based Nursing Care in Stroke and Neurovascular Conditions provides a comprehensive and practical guide for novice, experienced and advanced practice nurses working with patients suffering from stroke and other neurovascular conditions. With a focus specifically on neurovascular disorders, this highly detailed text offers easy-to-find information on evidence-based care guidelines.
  • Dr. James Wright, Associate Editor for the Journal of Bone and Joint Surgery, presents this landmark publication and novel approach to orthopaedic problems and solutions. This new, evidence-based reference examines clinical options and discusses relevant research evidence to provide you with expert recommendations for best practice. The consistent chapter format and featured summary tables provide "at-a-glance" access to the evidence-based literature and clinical options. Leading authorities contribute their expertise so you can apply the most effective clinical solutions to the persistent questions you encounter in your practice.
  • Also available: Print – 2008
  • This book is updated with evidence from the latest published reviews and is more clinically focused, with an emphasis on application of the trial findings. With increased coverage of trials in the area of supportive care for pediatric cancer patients, each chapter opens with a clinical question and concludes with a summary on the trial findings from an expert commentator.
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  • 2012 ClinicalKey
    Pt. 1. Introduction. What is evidence-based physical diagnosis? -- Pt. 2. Understanding the evidence. Diagnostic accuracy of physical findings -- Using the tables in this book -- Reliability of physical findings -- Pt. 3. General appearance of the patient. Mental status examination -- Stance and gait -- Jaundice -- Cyanosis -- Anemia -- Hypovolemia -- Protein-energy malnutrition and weight loss -- Obesity -- Cushing syndrome -- Pt. 4. Vital signs. Pulse rate and contour -- Abnormalities of pulse rhythm -- Blood pressure -- Temperature -- Respiratory rate and abnormal breathing patterns -- Pulse oximetry -- Pt. 5. Head and neck. The pupils -- Diabetic retinopathy -- Hearing -- Thyroid and its disorders -- Meninges -- Peripheral lymphadenopathy -- Pt. 6. the lungs. Inspection of the chest -- Palpation and percussion of the chest -- Auscultation of the lungs -- Ancillary tests -- Pt. 7. Selected pulmonary disorders. Pneumonia -- Chronic obstructive lung disease -- Pulmonary embolism -- Pleural effusion -- Pt. 8. The heart. Inspection of the neck veins -- Percussion of the heart -- Palpation of the heart -- Auscultation of the heart: general principles -- The first and second heart sounds -- The third and fourth heart sounds -- Miscellaneous heart sounds - Heart murmurs: general principles -- Pt. 9. Selected cardiac disorders. Aortic stenosis -- Aortic regurgitation -- Miscellaneous heart murmurs -- Disorders of the pericardium -- Congestive heart failure -- Coronary artery disease -- Pt. 10. Abdomen. Inspection of the abdomen -- Palpation and percussion of the abdomen -- Abdominal pain and tenderness -- Auscultation of the abdomen -- Pt. 11. Extremities. Peripheral vascular disease -- The diabetic foot -- Edema and deep vein thrombosis -- Examination of the musculoskeletal system -- Pt. 12. Neurologic examination. Visual field testing -- nerves of the eye muscles (III, IV, and VI): approach to diplopia -- Miscellaneous cranial nerves -- Examination of the motor system: approach to weakness -- Examination of the sensory system -- Examination of the reflexes -- Disorders of the nerve roots, plexuses, and peripheral nerves -- Coordination and cerebellar testing -- Pt. 13. Selected neurologic disorders. Tremor and Parkinson disease -- Hemorrhagic versus ischemic stroke -- Acute vertigo and imbalance -- Examination of nonorganic neurologic disorders -- Pt. 14. Examination in the intensive care unit. Examination of patients in the intensive care unit -- Appendix. Likelihood ratios, confidence intervals, and pretest probability.
  • Introduction: research synthesis in evidence-based clinical decision-making -- Overview, strengths, and limitations of systematic reviews and meta-analyses -- Understanding and interpreting systematic review and meta-analysis results -- Making evidence-based decisions in nursing -- A model for implementing evidence-based decisions in dental practice -- Evidence-based decisions in human immunodeficiency virus infection and cardiac disease -- Bringing evidence basis to decision making in complementary and alternative medicine (CAM): prakriti (constitution) analysis in Ayurveda -- Evidence-based clinical decisions in oral surgery -- Evidence-based issues in maxillofacial trauma -- Strengths and limitations of the evidence-based movement aimed to improve clinical outcomes in dentistry and oral surgery -- Evidence-based decisions for pharmacological management of alcoholic liver disease and alcohol dependence -- Temporomandibular joint disorders, a bibliometric evidence-based approach to analysis -- The efficacy of horizontal and vertical bone augmentation procedures for dental implants: a Cochrane systematic review -- Evidence-based medicine: what does it mean and where are we going? -- Future avenues of research synthesis for evidence-based clinical decision making.
  • pt. I. Evidence-Based and Comparative Effectiveness Analysis -- 1. Fundamentals: Evidence-Based Practice in Complementary and Alternative Medicine: Perspectives, Protocols, Problems, and Potentials / Francesco Chiappelli -- pt. II. Evidence-Based Medicine and Ayurveda -- 2. Transforming Ayurveda: Stepping into the Realm of Evidence-Based Practice / Ram Harsh Singh -- 3. Diet and Nutrition Concepts in Ayurveda: Gleaming into Opportunities for Evidence-Based Applications in Health Care / Rajiv Rastogi -- 4. Clinical Evidence in the Tradition of Ayurveda / P. Ram Manohar -- 5. Evidence-Based Traditional Persian Medicine / Francesco Chiappelli -- pt. III. Substantiating Ayurvedic Theory and Practice Toward Evidence-Base -- 6. Prakriti Analysis in Ayurveda: Envisaging the Need of Better Diagnostic Tools / Sanjeev Rastogi -- 7. Panchakarma: Ayurvedic Detoxification and Allied Therapies---Is There Any Evidence? / Ingebritt Ziegler -- 8. Gut and Joint Interconnections: A Reappraisal to Ayurvedic Understanding of Joint Diseases / Ranjana Rastogi -- 9. Ayurvedic Approach to Cardiovascular Diseases: Delineating the Literary and Clinical Evidences / P.S. Srivastav -- 10. Rasayana Therapy and Rejuvenation / Sanjeev Rastogi -- 11. Translational Effectiveness in Ayurvedic Medicine: Implications for Oral Biology and Medicine / Francesco Chiappelli -- pt. IV. Towards Future Perspectives of Evidence-Based Ayurveda -- 12. Safety Aspects of Ayurvedic Drugs / Arun Gupta -- 13. Toward Evidence-Based Practice of Ayurveda: Extrapolating the Challenges in the Current Decade / Sanjeev Rastogi.
  • The ethical debate on evidence-based medicine - introduction to the volume -- Regulating health care. The development of guidelines in medical practice and health policy -- Evidence-based medicine and power shifts in health care systems -- Beyond legitimate science: the case for policy-related science -- Teaching evidence-based medicine -- Evidence-based medicine and clinical guidelines in cardiology. Promoting science, practice, or bureaucracy? -- Are particular patients disadvantaged by EBM? Focus on frail elderly patients -- Evidence-based medicine in mental health: towards better and fairer treatment? -- Current epistemological problems in evidence-based medicine -- Coordinating the norms and values of medical research, medical practice and patient worlds. The ethics of evidence-based medicine in 'boundary fields of medicine' -- Research ethics and evidence-based medicine -- Clinical evaluative research: which patients benefit, how and when? A contribution to a European discussion -- Defining a proper background for discussing evidence-based medicine -- Evidence-based medicine and equity: the exclusion of disadvantaged groups -- The role of formal outcome evaluations in health policy making: a normative perspective -- The usefulness of formal outcome evaluations in health policy making: looking for the baby in the bathwater -- Evidence-based medicine and managed care -- Recommendations from the Evibase project.
  • 1. Evidence-Based Practice Parameters : The Approach of the American Society of Anesthesiologists -- 2. Update on Preprocedure Testing -- 3. Is a Preoperative Screening Clinic Cost-Effective? -- 4. Who Should Have a Preoperative 12-Lead Electrocardiogram? -- 5. Is Routine Preoperative Pregnanc y Testing Necessary? -- 6. What Are the Risk Factors for Perioperative Stroke? -- 7. Should We Delay Surgery in the Patient with Recent Cocaine Use? -- 8. Should All Antihypertensive Agents Be Continued before Surgery? -- 9. What Is the Optimal Timing for Smoking Cessation? -- 10. Which Patient Should Have a Preoperative Cardiac Evaluation (Stress Test)? -- 11. Should Patients with Stable Coronary Artery Disease Undergo Prophylactic Revascularization before Noncardiac Surgery? -- 12. What Are the Role and Management of Percutaneous Coronary Intervention for Noncardiac Surgery? -- 13. How Should We Prepare the Patient with a Pacemaker/Implantable Cardioverter-Defibrillator? -- 14. When Should Pulmonary Function Tests Be Performed Preoperatively? -- 15. Does the Airway Examination Predict Difficult Intubation? -- 16. Is There a Best Approach for Patients with Difficult Airways : Regional versus General Anesthesia? -- 17. What Is the Optimal Airway Management in Patients Undergoing Gastrointestinal Endoscopy? -- 18. Is There a Best Approach to Induction of Anesthesia in Emergent Situations? -- 19. Do Inhalational Agents Have Beneficial or Harmful Effects on Ischemia-Reperfusion Injury? -- 20. Does Anesthetic Choice Affect Surgical and Recovery Times? -- 21. What Are the Benefits of Different Ventilatory Techniques? -- 22. Is There an Optimal Perioperative Hemoglobin Level? -- 23. When Are Platelets and Plasma Transfusions Indicated? -- 24. What Drugs Decrease Perioperative Bleeding? -- 25. Does Perioperative Hyperglycemia Increase Risk? Should We Have Aggressive Glucose Control Perioperatively? -- 26. When and Why Should Perioperative Glucocorticoid Replacement Be Administered? -- 27. Does the Choice of Fluid Matter in Major Surgery? -- 28. What Works in a Patient with Acute Respiratory Distress Syndrome? -- 29. What Actions Can Be Used to Prevent Peripheral Nerve Injury? 30. What Is the Best Means of Preventing Perioperative Renal Injury? -- 31. Does Nitrous Oxide Affect Outcomes? -- 32. Are Alpha-2 Agonists Effective in Reducing Perioperative Cardiac Complications in Noncardiac Surgery? -- 33. What Is the Role of Ketamine in Perioperative Management? -- 34. Should Hypothermia Be Used Routinely after Intraoperative Cardiac Arrest? -- 35. Which Are the Best Techniques for Reducing the Incidence of Postoperative Deep Vein Thrombosis? -- 36. Are There Special Techniques in Obese Patients? -- 37. Is There an Ideal Approach to the Patient Susceptible to Malignant Hyperthermia? -- 38. What Is the Best Strategy for Prevention of Postoperative Nausea and Vomiting? -- 39. How Should Beta-Blockers Be Used Perioperatively? -- 40. How Can We Prevent Postoperative Cognitive Dysfunction? -- 41. Do Intensive Care Specialists Improve Patient Outcomes? -- 42. Fast-Track Cardiac Anesthesia : What Works Best for Safety and Efficacy? -- 43. Can We Prevent Recall during Anesthesia? -- 44. Are Patients with Sleep Apnea Appropriate for Ambulatory Surgery? -- 45. What Criteria Should Be Used for Discharge after Outpatient Surgery? -- 46. What Must I Consider in Order to Safely Anesthetize Someone in the Office Setting? -- 47. Is Propofol Safe If Given by Nonanesthesia Providers? -- 48. Aspiration : Is There an Optimal Management Strategy? -- 49. Nonsteroidal Antiinflammatory Drugs, Antiplatelet Medications, and Spinal Axis Anesthesia -- 50. DVT Prophylaxis with Heparin and Heparin-Like Drugs (UH, LMWH, Fondaparinux, and Rivaroxaban) Used in Combination with Neuraxial Anesthesia and Deep Plexus Blocks -- 51. Is Regional Anesthesia Appropriate for Outpatient Surgery? -- 52. What Is the Best Technique for Hip Surgery? -- 53. Does Intraoperative Regional Anesthesia Decrease Perioperative Blood Loss? -- 54. What Is the Optimal Management of Postdural Puncture Headache? -- 55. Should Ultrasound Guidance Be the Standard of Practice for Peripheral Nerve Blockade? -- 56. Should Regional Anesthesia Be Used for Orthopedic Trauma Patients? -- 57. What Is the Best Method of Diagnosing Perioperative Myocardial Infarction? -- 58. Does Neurologic Electrophysiologic Monitoring Affect Outcome? -- 59. Is Regional Superior to General Anesthesia for Infrainguinal Revascularization? -- 60. Is There a Best Technique to Decrease Blood Loss and Transfusion after Coronary Artery Bypass Grafting? -- 61. Should Thoracic Epidural/Spinal Analgesia be Used for Coronary Artery Bypass Grafting? -- 62. Is There a Best Technique in the Patient with Increased Intracranial Pressure? -- 63. What Works for Brain Protection? -- 64. Anesthesia for Cesarean Delivery : Regional or General? -- 65. When Should a Combined Spinal-Epidural Be Used? 66. Does Labor Analgesia Affect Labor Outcome? -- 67. Does Anesthesia Increase the Risk to the Parturient Undergoing Nonobstetric Surgery? -- 68. How Young Is the Youngest Infant for Outpatient Surgery? -- 69. Should a Child with a Respiratory Tract Infection Undergo Elective Surgery? -- 70. When Should Regional Anesthesia Be Used in Pediatric Patients? -- 71. Optimal Postoperative Analgesia -- 72. Is Pre-Emptive Analgesia Clinically Effective?
  • Evidence-Based Practice of Critical Care, edited by Drs. Clifford S. Deutschman and Patrick J. Neligan, provides objective data and expert guidance to help answer the most important questions challenging ICU physicians today. It discusses the clinical options, examines the relevant research, and presents expert recommendations on everything from acute organ failure to prevention issues. An outstanding source for "best practices" in critical care medicine, this book is a valuable framework for translating evidence into practice. It also provides access to the full text online, with regular updates to emerging clinical evidence. Gain valuable evidence-based recommendations on key topics such as acute organ failure, infection, sepsis and inflammation, and prevention issues pointing the way to the most effective approaches. Get an overview of each question, an outline of management options, a review of the relevant evidence, areas of uncertainty, existing management guidelines, and authors₂ recommendations. Navigate a full range of challenges from routine care to complicated and special situations. Find the information you need quickly with tables that summarize the available literature and recommended clinical approaches. Stay current on the latest advances in the field with full-text, online access that includes regular updates to emerging clinical evidence.
  • 1. How Should Opioids Be Started and Titrated in Routine Outpatient Settings? -- 2. How Should Opioids Be Started and Titrated in Hospital or Inpatient Settings? -- 3. How Should Patient-Controlled Analgesia Be Used in Patients With Serious Illness and Those Experiencing Postoperative Pain? -- 4. How Should Opioids Be Used to Manage Pain Emergencies? -- 5. What Principles Should Guide Oral, Transcutaneous, and Intravenous Opioid Dose Conversions? -- 6. Which Opioids Are Safest and Most Effective in Renal Failure? -- 7. How Should Methadone Be Started and Titrated in Opioid-Naïve and Opioid-Tolerant Patients? -- 8. What Special Considerations Should Guide the Safe Use of Methadone? -- 9. When Should Corticosteroids Be Used to Manage Pain? -- 10. When Should Nonsteroidal Antiinflammatory Drugs Be Used to Manage Pain? -- 11. What Is Neuropathic Pain? How Do Opioids and Nonopioids Compare for Neuropathic Pain Management? -- 12. Should Bisphosphonates Be Used Routinely to Manage Pain and Skeletal Complications in Cancer? -- 13. Should Bisphosphonates Be Used Routinely to Manage Pain and Skeletal Complications in Other Conditions? -- 14. When Should Radiotherapy Be Considered for Pain Management and What Principles Should Guide the Consideration of Limited-Fraction Versus Full-Dose Radiotherapy? -- 15. When Should Radiopharmaceuticals Be Considered for Pain Management? -- 16. What Principles Should Guide the Prescribing of Opioids for Non-Cancer-Related Pain? -- 17. What Approaches Should Be Used to Minimize Opioid Diversion and Abuse in Palliative Care? -- 18. When Should Epidural or Intrathecal Opioid Infusions and Pumps Be Considered for Pain Management? -- 19. When Should Nerve Blocks Be Used for Pain Management? -- 20. What Interventions Are Effective for Managing Dyspnea in Cancer? -- 21. What Is the Role of Opioids in Treatment of Refractory Dyspnea in Advanced Chronic Obstructive Pulmonary Disease? -- 22. What Nonopioid Treatments Should Be Used to Manage Dyspnea Associated With Chronic Obstructive Pulmonary Disease? -- 23. What Interventions Are Effective for Managing Dyspnea in Heart Failure? -- 24. What Medications Are Effective in Preventing and Relieving Constipation in the Setting of Opioid Use? -- 25. How Should Medications Be Initiated and Titrated to Reduce Acute and Delayed Nausea and Vomiting in the Setting of Chemotherapy? -- 26. How S hould Medications Be Initiated and Titrated to Prevent and Treat Nausea and Vomiting in Clinical Situations Unrelated to Chemotherapy? -- 27. What Interventions Are Effective for Relieving Acute Bowel Obstruction in Cancer and Other Conditions? -- 28. What Medications Are Effective in Improving Anorexia and Weight Loss in Cancer? -- 29. What Therapeutic Strategies Are Effective in Improving Anorexia and Weight Loss in Nonmalignant Disease? -- 30. When Should Enteral Feeding by Percutaneous Tube Be Used in Patients With Cancer and in Patients With Non-Cancer-Related Conditions? -- 31. When Should Parenteral Feeding Be Considered for Patients With Cancer and for Patients With Non-Cancer-Related Conditions? -- 32. How Does One Assess for Psychiatric Illness in Patients With Advanced Disease? -- 33. What Treatments Are Effective for Depression in the Palliative Care Setting? -- 34. What Treatments Are Effective for Anxiety in Patients With Serious Illness? -- 35. What Is Delirium? -- 36. What Are Effective Pharmacological Treatments for Delirium? -- 37. What Nonpharmacological Treatments Are Effective for Delirium? -- 38. What Are the Differences When Treating a Patient at the End of Life With Delirium (Terminal Delirium)? -- 39. How Do Symptoms Change for Patients in the Last Days and Hours of Life? -- 40. What Is Known About Prognostication in Advanced Illness? -- 41. What Is a Useful Strategy for Estimating Survival in Palliative Care Settings for Persons With Advanced Cancer? -- 42. What Is a Useful Strategy for Estimating Survival for Persons With Advanced Non-Cancer-Related Illness in Palliative Care Settings? -- 43. What Are the Key Elements to Having a Conversation About Setting Goals and Communicating Serious News? -- 44. What Do Palliative Care Clinicians Need to Know About Teaching Communication? -- 45. What Are Advance Care Plans and How Are They Different From Advance Directives? -- 46. What Elements Are Essential to Effective Advance Care Planning? -- 47. What Is the Evidence That Advance Care Plans Change Patient Outcomes? -- 48. What Is the Role for Palliative Care in Patients With Advanced Cancer? -- 49. What Is the Clinical Course of Advanced Cancer? -- 50. What Is the Relationsh ip Between Patient Performance Status and Ability to Offer Chemotherapeutic Treatments? -- 51. What Is the Clinical Course of Advanced Dementia? -- 52. What Are Appropriate Palliative Interventions for Patients With Advanced Dementia? -- 53. What Is the Clinical Course of Advanced Liver Disease and What Symptoms Are Associated With It? -- 54. What Special Considerations Are Needed for Treating Patients With Chronic Liver Disease? -- 55. What Is the Role of Palliative Care in Stroke? -- 56. What Special Considerations Are Needed for Individuals With Amyotrophic Lateral Sclerosis, Multiple Sclerosis, or Parkinson Disease? -- 57. What Is the Clinical Course of Advanced Heart Failure and How Do Implanted Cardiac Devices Alter This Course? -- 58. What Is Chronic Critical Illness and What Outcomes Can Be Expected? -- 59. What Special Considerations Are Needed in Patients With Head and Neck Cancer? -- 60. What Special Considerations Are Needed in Treating Symptoms in Patients With End-Stage Renal Disease? -- 61. How Is the Patient Who Stops Dialysis Best Managed? -- 62. Which Patients With End-Stage Renal Disease Should Not Be Started on Dialysis? -- 63. What Is Frailty? -- 64. What Are the Special Needs of Patients With Frailty? -- 65. What Are Special Considerations for Treating Pediatric Patients and Their Families? -- 66. What Are the Signs and Symptoms of Spinal Cord Compression? -- 67. What Are the Best Pharmacological and Surgical Treatments for Patients With Spinal Cord Compression? -- 68. What Techniques Can Be Used in the Hospital or Home Setting to Best Manage Uncontrollable Bleeding? -- 69. What Can Be Done for Patients With Crisis Dyspnea? -- 70. What Are the Arguments That Show That Palliative Care Is Beneficial to Hospitals? -- 71. What Are the Arguments That Show Outpatient Palliative Care Is Beneficial to Medical Systems? -- 72. What Is the Eff ect of Serious Illness on Caregivers? -- 73. What Can Be Done to Improve Outcomes for Caregivers of Patients With Serious Illness? -- 74. What Is Prolonged Grief Disorder and How Can Its Likelihood Be Reduced? -- 75. What Are the Eligibility Criteria for Hospice? -- 76. In What Settings Can Hospice Be Provided? -- 77. What Models Exist for Delivering Palliative Care and Hospice in Nursing Homes? -- 78. How Can Palliative Care Be Integrated Into Home-Based Primary Care Programs? -- 79. What New Models Exist for Ambulatory Palliative Care? -- 80. What New Models Exist for Palliative Care in the Emergency Department? -- 81. What Are Sources of Spiritual and Existential Suffering for Patients With Advanced Disease?
  • Evidence-based practices in autism: Where we started / Brian Reichow and Fred R. Volkmar -- Development, procedures, and application of the evaluative method for determining evidence-based practices in autism / Brian Reichow -- On the reliability and accuracy of the evaluative method for identifying evidence-based practices in autism / Domenic V. Cicchetti -- evidence-based treatment of behavioral excesses and deficits for individuals with autism spectrum disorders / Michael D. Powers, Mark J. Palmieri, Kristen S. D'Eramo, and Kristen M. Powers -- Evidence-based treatments in communication for children with autism spectrum disorders / Patricia A. Prelock, Rhea Paul, and Elizabeth M. Allen -- Treatments to increase social awareness and social skills / Suzannah J. Ferraioli and Sandra L. Harris -- Cognitive behavioral therapy in high-functioning autism: Review and recommendations for treatment development / Jeffrey J. Wood, Cori Fujii, and Patricia Renno -- Psychopharmacology in children with PDD: Review of current evidence / Lawrence Scahill and Susan Griebell Boorin -- Interventions that address sensory dysfunction for individuals with Autism Spectrum Disorders: Preliminary evidence for the superiority of sensory integration compared to other sensory approaches / Roseann C. Schaaf -- Dietary, complementary, and alternative therapies / Susan L. Hyman and Susan E. Levy -- The role of adaptive behavior in evidence-based practices for ASD: Translating intervention into functional success / Katherine D. Tsatsanis, Celine Saulnier, Sara S. Sparrow, and Domenic V. Cicchetti -- Practicing evidence-based practices / Ruth Blennerhassett Eren and Pamela Owen Brucker -- The implementation of evidence-based practices in public schools / Peter Doehring and Vincent Winterling -- Evidence-based practices in autism: Where we are now and where we need to go / Fred R. Volkmar, Brian Reichow, and Peter Doehring.
  • Covers the spectrum of procedural dermatology, including skin cancer surgery, laser techniques, fillers and neurotoxins, minimally invasive co