Bookedited by Swati Nagar, Upendra A. Argikar, Donald J. Tweedie.
Contents:
Enzyme Kinetics in Drug Metabolism : Fundamentals and Applications
Fundaments of Enzyme Kinetics
Different Enzyme Kinetic Models
Reversible Mechanisms of Enzyme Inhibitors and Resulting Clinical Significance
Irreversible Enzyme Inhibition Kinetics and Drug-Drug Interactions
Multi-Enzyme Kinetics and Sequential Metabolism
Consideration of the Unbound Drug Concentration in Enzyme Kinetics
Enzyme Kinetics of Oxidative Metabolism : Cytochromes P450
Enzyme Kinetics, Pharmacokinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase
Enzyme Kinetics of Conjugative Enzymes : PAPS
Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs)
Principles and Experimental Considerations for in vitro Transporter Interaction Assays
Rationalising Under-Prediction of Drug Clearance from Enzyme and Transporter Kinetic Data : from in vitro Tools to Mechanistic Modeling
The Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers
Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism
Variability in Human in vitro Enzyme Kinetics
Sources of Interindividual Variability
Case Study 1. Practical Considerations with Experimental Design and Interpretation
Case Study 2. Practical Analytical Considerations for Conducting in vitro Enzyme Kinetic Studies
Case Study 3. Application of Basic Enzyme Kinetics to Metabolism Studies : Real Life Examples
Case Study 4. Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast
Case Study 5. Deconvoluting Hyperbilirubinemia: Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A, MRP2 or OATP1B1 in Drug Development
Case Study 6. Drug Transporters: in vitro Solutions for Translatable Outcomes
Case Study 7. Compiled Aha Moments in Enzyme Kinetics: Authors' Experiences.