BookNosheen Masood, Saima Shakil Malik, editors.
Summary: This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.
Contents:
1: Overview of Cancer Genomics, Organization, and Variations in the Human Genome
2: Metabolic Changes and Their Characterization
3: Unravelling the Genomic Targets of Small Molecules and Application of CRISPR-Cas 9 System for Genomic Editing in Cancer with Respective Clinical Applications
4: Genome Editing in Cancer Research and Cure
5: New Adsorption-Based Biosensors for Cancer Detections and Role of Nano-medicine in Its Prognosis and Inhibition
6: Genomic Instability and Cancer Metastasis
7: DNA Damage Response Pathways in Cancer Predisposition and Metastasis
8: Adapting the Foreign Soil: Factors Promoting Tumor Metastasis
9: MicroRNAs in Cancer: From Diagnosis to Therapeutics
10: Metabolic and Enzyme Engineering for the Microbial Production of Anticancer Terpenoids
11: Translational Research in Oncology
12: Molecular Profiling of Breast Cancer in Clinical Trials: A Perspective
13: Systems Biology and Integrated Computational Methods for Cancer-Associated Mutation Analysis
14: Biostatistics in Clinical Oncology
15: History of Drug Reaction in Children Suffering from Cancer
16: Pharmacogenomics of Cisplatin-Induced Toxicity in Children
17: Pharmacogenomics of Methotrexate-Induced Toxicity in Children
18: Pharmacogenomics of Thiopurine-Induced Toxicity in Children
19: Pharmacogenetics in Cancer Treatment: Challenges and Recent Trends
20: Precision Nutraceutical Approaches for the Prevention and Management of Cancer
21: Cancer Genomics in Precision Oncology: Applications, Challenges, and Prospects