BookKarl L. Mettinger, Pranela Rameshwar, Vinod Kumar, editors.
Summary: "This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well as improved health span and life span. The use of exosomes from body fluids to define specific biomarkers for various tumors may also clear the path to patient-targeted treatments by developing exosome-derived microRNA based cancer therapeutics. It is essential reading for graduate students, research fellow and biomedical researchers in academia or the pharmaceutical or biotech industries"--Publisher's description.
Contents:
Part I. A new stem cell biology: transplantation and baseline, cell cycle and exosomes / Peter Quesenberry, Laura R. Goldberg
The emerging roles of microRNAs in stem cell aging / Catharine Dietrich, Manish Singh, Nishant Kumar, Shree Ram Singh
Part II. Treating age-related diseases with somatic stem cells / Robert W. Brooks, Paul D. Robbins
Targeting miRNA for therapy of juvenile and adult diabetic cardiomyopathy / Shyam Sundar Nandi, Paras Kumar Mishra
Stem cell therapies for neurodegenerative diseases / Kiminobu Sugaya, Manjusha Vaidya
Part III. MicroRNAs, regulatory messengers inside and outside cancer cells / Simone Anfossi, Xiao Fu, Rahul Nagvekar, George A. Calin
Exosomes function in tumor immune microenvironment / Yin Huang, Keli Liu, Qing Li, Yikun Yao, Ying Wang
EV, microvesicles/microRNAs and stem cells in cancer / Jacob A. Tickner, Derek J. Richard, Kenneth J. O'Byrne
Human aging and cancer: role of miRNA in tumor microenvironment / Oleta A. Sandiford [and others].